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Яндекс Яндекс

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Описание

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Фосфоглив капс., 50 шт.

Name: Фосфоглив капс.
Brand: Фармстандарт-Лексредства
Price: 666 RUR
Availability: InStock
Rating: 4.8 (239 reviews)

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Артикул Маркета

103543417447

Тип препарата

лекарственный препарат

Назначение

гепатоз, интоксикация, нейродермит, острые гепатиты, псориаз, токсические поражения печени, хронические гепатиты, цирроз печени, экзема

Действующее вещество

Глицирризиновая кислота+фосфолипиды

Форма выпуска

капсулы

Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.

Есть противопоказания, посоветуйтесь с врачом

Все товары Фармстандарт-Лексредства

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Пэй

673 ₽

–1%

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Фосфоглив капс., 50 шт.

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Цена с картой Яндекс Пэй:666 ₽

Скидка: 1%

–1 %

Вместо: 673 ₽

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ЗдравСити - сервис заказа и выдачи лекарств

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Все 4 предложения

от 618 рублей

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Инструкция

Артикул Маркета

103543417447

Бренд

Фармстандарт-Лексредства

Количество штук в упаковке

50 шт.

Тип препарата

лекарственный препарат

Органы и системы

кожа, печень

Назначение

Показания к применению

— жировая дегенерация печени (гепатоз);— другие поражения печени (алкогольные, токсические, в т.ч. лекарственные);— в составе комплексной терапии вирусных гепатитов, цирроза печени, и псориаза.

Противопоказания

— антифосфолипидный синдром;— беременность (данных по эффективности и безопасности недостаточно);— период лактации (данных по эффективности и безопасности недостаточно);— детский возраст до 12 лет;— повышенная чувствительность к глицирризиновой кислоте, фосфатидилхолину или другим компонентам препарата.

Состав

1 капс.: фосфолипиды (липоид С80) (в пересчете на основной компонент - фосфатидилхолин 73-79%) - 65 мг, натрия глицирризинат (тринатриевая соль глицирризиновой кислоты) - 35 мг.

Действующее вещество

Глицирризиновая кислота+фосфолипиды

Способ применения и дозы

Препарат принимают внутрь во время еды. Капсулы следует проглатывать, не разжевывая, запивая небольшим количеством жидкости.Взрослым и детям старше 12 лет назначают по 2 капс. 3 раза/сут.Длительность применения может составлять до 6 мес, в среднем - 3 мес.

Побочные действия

Обычно препарат Фосфоглив переносится хорошо, побочные действия развиваются очень редко, по данным пострегистрационного наблюдения частота <1/10 000.Аллергические реакции: кожная сыпь, затруднение носового дыхания, конъюнктивит, кашель.Со стороны сердечно-сосудистой системы: транзиторное (преходящее) повышение АД, периферические отеки.Со стороны пищеварительной системы: диспепсия (отрыжка, тошнота, вздутие живота), дискомфорт в животе.При возникновении перечисленных симптомов следует прекратить прием препарата и проконсультироваться с врачом.

Фармакологическое действие

Комбинированное средство. Оказывает гепатопротекторное, мембраностабилизирующее и противовирусное действие. Глицирризиновая кислота оказывает гепатопротекторное действие за счет антиоксидантного, противовоспалительного эффектов, а также влияния на фиброгенез. Антиоксидантное действие. Глицирризиновая кислота связывает свободные кислородные радикалы и ингибирует ферменты, инициирующие перекисное окисление липидов (ПОЛ) в гепатоцитах. Противовоспалительное действие. Глицирризиновая кислота уменьшает воспаление за счет ингибирующего влияния на NF-kB- и ТLR4-сигнальные пути; угнетения продукции провоспалительных цитокинов (ФHОα, ИЛ-1, ИЛ-6, ИЛ-8); стимулирования продукции противовоспалительных цитокинов (ИЛ-2, ИЛ-10. ИЛ-12). Глицирризиновая кислота ингибирует 11β-оксистероиддегидрогеназу, что способствует повышению эндогенного кортизола в крови (псевдокортикостероидный эффект). Влияние на фиброгенез связано с уменьшением экспрессии гена коллагена 1-го типа и снижением продукции коллагена звездчатыми клетками печени (клетками Ито), а также разрушением активированных клеток Ито через систему натуральных киллеров, что способствует замедлению прогрессирования фиброза. Подавляет репродукцию вирусов в печени и других органах за счет стимуляции продукции интерферонов, повышения фагоцитоза, увеличения активности естественных клеток-киллеров. При поражениях кожи за счет противовоспалительного действия ограничивает распространение процесса и способствует регрессу заболевания. Фосфатидилхолин (действующее вещество фосфолипидов) является основным структурным элементом клеточных и внутриклеточных мембран, восстанавливает их структуру и функции при повреждении, оказывая мембраностабилизирующее действие. Нормализует белковый и липидный обмены, предотвращает потерю гепатоцитами ферментов и других активных веществ, способствует восстановлению функций печени. Глицирризиновая кислота. После перорального приема в кишечнике под влиянием фермента β-глюкуронидазы, продуцируемого бактериями нормальной микрофлоры, из глицирризиновой кислоты образуется активный метаболит - β-глицирретовая кислота, которая всасывается в системный кровоток. В крови β-глицирретовая кислота связывается с альбумином и практически полностью транспортируется в печень. Выделение β-глицирретовой кислоты происходит преимущественно с желчью, в остаточном количестве - с мочой. По экспериментальным данным, фосфолипиды улучшают липофильные свойства глицирризиновой кислоты, увеличивая интенсивность и скорость ее всасывания более чем в 2 раза. Фосфатидилхолин. Более 90% принятых внутрь фосфолипидов всасывается в тонкой кишке. Большая часть их расщепляется фосфолипазой А до 1-ацетил-лизофосфатидилхолина, 50% которого подвергается обратному ацетилированию в полиненасыщенный фосфатидилхолин в процессе всасывания в слизистой оболочке кишечника. Полиненасыщенный фосфатидилхолин с током лимфы попадает в кровь, откуда, главным образом, в связанном с липопротеинами высокой плотности виде поступает в печень. Фармакокинетика у людей изучалась с помощью диленолеил фосфатидилхолина с радиоактивной меткой - 3Н (холиновая часть) и 14С (остаток линолевой кислоты). Максимальная концентрация 3Н достигается через 6-24 часа, составляя 19,9% от назначенной дозы; 14С - через 4-12 часов, составляя 27,9%. Период полувыведения холинового компонента равен 66 часам, остатка линолевой кислоты - 32 часам. В кале обнаруживается 2% 3Н и 4,5% - 14С; в моче - 6% 3Н и минимальное количество 14С. Оба изотопа всасываются в кишечнике более чем на 90%.

Фармакологическая группа

гепатопротекторы

Форма выпуска

капсулы

Способ применения/введения

пероральный

Условия хранения

Препарат следует хранить в недоступном для детей месте при температуре не выше 25°C. Срок годности - 3 года.

Передозировка

В настоящее время случаи передозировки препарата Фосфоглив не зарегистрированы.

Применение при беременности и кормлении грудью

Препарат противопоказан при беременности и в период грудного вскармливания (данных по эффективности и безопасности недостаточно).

Влияние на способность управлять транспортом и механизмами

Препарат не оказывает негативного влияния на способность управлять транспортными средствами и выполнять другую работу, требующую повышенной концентрации внимания и быстроты психомоторных реакций.

Особые указания

В случае повышения артериального давления следует прекратить прием препарата и обратиться к врачу.С осторожностью следует назначать препарат пациентам с портальной гипертензией, артериальной гипертензией. При наличии данных заболеваний перед началом препарата необходимо проконсультироваться с врачом.

Взаимодействие

Лекарственное взаимодействие препарата Фосфоглив не описано.

Регистрационный номер

P N002528/01

Дата государственной регистрации

09.01.2023

Бренд

Фармстандарт-Лексредства

Изготовитель

Фармстандарт-Лексредства

Фасовщик

Фармстандарт-Лексредства

Страна бренда

Россия

Страна-производитель

Россия

Название препарата

Фосфоглив

Срок годности

37 мес.

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Полная инструкция

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Отзывы

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188 оценок•26 отзывов

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15 мая•Анна Мальцева•Куплен на Маркете

Достоинства: Помогает, если есть высыпания на коже, значит, печень не справляется с детоксом. Препарат не панацея, но помогает печени фильтровать и выводить токсины. Важно так же чистое питание, не только таблетки разные, избавиться от сахара, молока и пр. А так Фосфоглив как поддержка почень помогает.
Недостатки: нет

3 мая•Имя скрыто•Куплен на Маркете

Комментарий: Фосфоглив подключаю к мази при обострении псориаза. Комплексное лечение срабатывает намного быстрее, и обострений дольше не появляется

7 августа 2024•Имя скрыто•Куплен на Маркете

Достоинства: Быстрое получение. Отличная цена. Лекарство с хорошим сроком годности.
Недостатки: Нет. Жалко не возможно было доставить в пункт выдачи
Комментарий: Лекарство отличное Надо принимать курсами.

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Войдите в аккаунтИ тогда откроется корзина, а цены на Маркете могут стать ниже

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Фосфоглив капс., 50 шт.

Инструкция

Отзывы

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