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Описание
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Фосфоглив капсулы 50шт

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Артикул Маркета
103543417447
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Тип препарата
Назначение
Действующее вещество
Форма выпуска
Инструкция
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом
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634 ₽
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Фосфоглив капс.
Фосфоглив капсулы 50шт
Задать вопрос
634 ₽
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Войдите, и станет дешевлеВ аккаунте больше скидок
Войти
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Доставка магазина
628 ₽Пэй
Завтра, курьер  99 ₽
Москва
634 ₽
Завтра, самовывоз из аптеки  0 ₽
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ЗдравСити - сервис заказа и выдачи лекарств
Магазин•4.8 188.4K оценок
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Инструкция
Артикул Маркета
103543417447
Бренд
Фармстандарт
Количество штук в упаковке
50 шт.
Тип препарата
лекарственный препарат
Органы и системы
кожа, печень
Назначение
гепатоз, интоксикация, нейродермит, острые гепатиты, псориаз, токсические поражения печени, хронические гепатиты, цирроз печени, экзема
Показания к применению
— жировая дегенерация печени (гепатоз);— другие поражения печени (алкогольные, токсические, в т.ч. лекарственные);— в составе комплексной терапии вирусных гепатитов, цирроза печени, и псориаза.
Противопоказания
— антифосфолипидный синдром;— беременность (данных по эффективности и безопасности недостаточно);— период лактации (данных по эффективности и безопасности недостаточно);— детский возраст до 12 лет;— повышенная чувствительность к глицирризиновой кислоте, фосфатидилхолину или другим компонентам препарата.
Состав
1 капс.: фосфолипиды (липоид С80) (в пересчете на основной компонент - фосфатидилхолин 73-79%) - 65 мг, натрия глицирризинат (тринатриевая соль глицирризиновой кислоты) - 35 мг.
Действующее вещество
Глицирризиновая кислота+фосфолипиды
Способ применения и дозы
Препарат принимают внутрь во время еды. Капсулы следует проглатывать, не разжевывая, запивая небольшим количеством жидкости.Взрослым и детям старше 12 лет назначают по 2 капс. 3 раза/сут.Длительность применения может составлять до 6 мес, в среднем - 3 мес.
Побочные действия
Обычно препарат Фосфоглив переносится хорошо, побочные действия развиваются очень редко, по данным пострегистрационного наблюдения частота <1/10 000.Аллергические реакции: кожная сыпь, затруднение носового дыхания, конъюнктивит, кашель.Со стороны сердечно-сосудистой системы: транзиторное (преходящее) повышение АД, периферические отеки.Со стороны пищеварительной системы: диспепсия (отрыжка, тошнота, вздутие живота), дискомфорт в животе.При возникновении перечисленных симптомов следует прекратить прием препарата и проконсультироваться с врачом.
Фармакологическое действие
Комбинированное средство. Оказывает гепатопротекторное, мембраностабилизирующее и противовирусное действие. Глицирризиновая кислота оказывает гепатопротекторное действие за счет антиоксидантного, противовоспалительного эффектов, а также влияния на фиброгенез. Антиоксидантное действие. Глицирризиновая кислота связывает свободные кислородные радикалы и ингибирует ферменты, инициирующие перекисное окисление липидов (ПОЛ) в гепатоцитах. Противовоспалительное действие. Глицирризиновая кислота уменьшает воспаление за счет ингибирующего влияния на NF-kB- и ТLR4-сигнальные пути; угнетения продукции провоспалительных цитокинов (ФHОα, ИЛ-1, ИЛ-6, ИЛ-8); стимулирования продукции противовоспалительных цитокинов (ИЛ-2, ИЛ-10. ИЛ-12). Глицирризиновая кислота ингибирует 11β-оксистероиддегидрогеназу, что способствует повышению эндогенного кортизола в крови (псевдокортикостероидный эффект). Влияние на фиброгенез связано с уменьшением экспрессии гена коллагена 1-го типа и снижением продукции коллагена звездчатыми клетками печени (клетками Ито), а также разрушением активированных клеток Ито через систему натуральных киллеров, что способствует замедлению прогрессирования фиброза. Подавляет репродукцию вирусов в печени и других органах за счет стимуляции продукции интерферонов, повышения фагоцитоза, увеличения активности естественных клеток-киллеров. При поражениях кожи за счет противовоспалительного действия ограничивает распространение процесса и способствует регрессу заболевания. Фосфатидилхолин (действующее вещество фосфолипидов) является основным структурным элементом клеточных и внутриклеточных мембран, восстанавливает их структуру и функции при повреждении, оказывая мембраностабилизирующее действие. Нормализует белковый и липидный обмены, предотвращает потерю гепатоцитами ферментов и других активных веществ, способствует восстановлению функций печени. Глицирризиновая кислота. После перорального приема в кишечнике под влиянием фермента β-глюкуронидазы, продуцируемого бактериями нормальной микрофлоры, из глицирризиновой кислоты образуется активный метаболит - β-глицирретовая кислота, которая всасывается в системный кровоток. В крови β-глицирретовая кислота связывается с альбумином и практически полностью транспортируется в печень. Выделение β-глицирретовой кислоты происходит преимущественно с желчью, в остаточном количестве - с мочой. По экспериментальным данным, фосфолипиды улучшают липофильные свойства глицирризиновой кислоты, увеличивая интенсивность и скорость ее всасывания более чем в 2 раза. Фосфатидилхолин. Более 90% принятых внутрь фосфолипидов всасывается в тонкой кишке. Большая часть их расщепляется фосфолипазой А до 1-ацетил-лизофосфатидилхолина, 50% которого подвергается обратному ацетилированию в полиненасыщенный фосфатидилхолин в процессе всасывания в слизистой оболочке кишечника. Полиненасыщенный фосфатидилхолин с током лимфы попадает в кровь, откуда, главным образом, в связанном с липопротеинами высокой плотности виде поступает в печень. Фармакокинетика у людей изучалась с помощью диленолеил фосфатидилхолина с радиоактивной меткой - 3Н (холиновая часть) и 14С (остаток линолевой кислоты). Максимальная концентрация 3Н достигается через 6-24 часа, составляя 19,9% от назначенной дозы; 14С - через 4-12 часов, составляя 27,9%. Период полувыведения холинового компонента равен 66 часам, остатка линолевой кислоты - 32 часам. В кале обнаруживается 2% 3Н и 4,5% - 14С; в моче - 6% 3Н и минимальное количество 14С. Оба изотопа всасываются в кишечнике более чем на 90%.
Фармакологическая группа
гепатопротекторы
Форма выпуска
капсулы
Способ применения/введения
пероральный
Условия хранения
Препарат следует хранить в недоступном для детей месте при температуре не выше 25°C. Срок годности - 3 года.
Передозировка
В настоящее время случаи передозировки препарата Фосфоглив не зарегистрированы.
Применение при беременности и кормлении грудью
Препарат противопоказан при беременности и в период грудного вскармливания (данных по эффективности и безопасности недостаточно).
Влияние на способность управлять транспортом и механизмами
Препарат не оказывает негативного влияния на способность управлять транспортными средствами и выполнять другую работу, требующую повышенной концентрации внимания и быстроты психомоторных реакций.
Особые указания
В случае повышения артериального давления следует прекратить прием препарата и обратиться к врачу.С осторожностью следует назначать препарат пациентам с портальной гипертензией, артериальной гипертензией. При наличии данных заболеваний перед началом препарата необходимо проконсультироваться с врачом.
Взаимодействие
Лекарственное взаимодействие препарата Фосфоглив не описано.
Регистрационный номер
P N002528/01
Дата государственной регистрации
09.01.2023
Бренд
Фармстандарт
Изготовитель
Фармстандарт-Лексредства
Фасовщик
Фармстандарт-Лексредства
Страна бренда
Россия
Страна-производитель
Россия
Название препарата
Фосфоглив
Срок годности
37 мес.
Сертификат лекарственного препарата
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— жировая дегенерация печени (гепатоз);
— другие поражения печени (алкогольные, токсические, в т.ч. лекарственные);
— в составе комплексной терапии вирусных гепатитов, цирроза печени, и псориаза.
— антифосфолипидный синдром;
— беременность (данных по эффективности и безопасности недостаточно);
— период лактации (данных по эффективности и безопасности недостаточно);
— детский возраст до 12 лет;
— повышенная чувствительность к глицирризиновой кислоте, фосфатидилхолину или другим компонентам препарата.
Препарат принимают внутрь во время еды. Капсулы следует проглатывать, не разжевывая, запивая небольшим количеством жидкости.
Взрослым и детям старше 12 лет назначают по 2 капс. 3 раза/сут.
Длительность применения может составлять до 6 мес, в среднем - 3 мес.

Отзывы

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190 оценок•26 отзывов
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user avatar
15 мая•Анна Мальцева•Куплен на Маркете
Достоинства: Помогает, если есть высыпания на коже, значит, печень не справляется с детоксом. Препарат не панацея, но помогает печени фильтровать и выводить токсины. Важно так же чистое питание, не только таблетки разные, избавиться от сахара, молока и пр. А так Фосфоглив как поддержка почень помогает.
Недостатки: нет
user avatar
3 мая•Имя скрыто•Куплен на Маркете
Комментарий: Фосфоглив подключаю к мази при обострении псориаза. Комплексное лечение срабатывает намного быстрее, и обострений дольше не появляется
user avatar
7 августа 2024•Имя скрыто•Куплен на Маркете
review-photo
Достоинства: Быстрое получение. Отличная цена. Лекарство с хорошим сроком годности.
Недостатки: Нет. Жалко не возможно было доставить в пункт выдачи
Комментарий: Лекарство отличное Надо принимать курсами.
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Войдите в аккаунтИ тогда откроется корзина, а цены на Маркете могут стать ниже
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