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Описание

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Тидомет форте таб., 250 мг+25 мг, 100 шт.

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Коротко о товаре

Артикул Маркета
3123937549
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
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Необходимо прекратить применение данных препаратов не менее, чем за 2 недели до начала применения препарата Тидомет Форте (за исключением селективных ингибиторов МАО-В (например, селегилина гидрохлорида)).\u003Cbr\u003EЗакрытоугольная глаукома.\u003Cbr\u003EПациенты с подозрением на недиагностированные кожные заболевания или меланомой в анамнезе (поскольку леводопа может стимулировать развитие злокачественной меланомы).\u003Cbr\u003EТяжелый психоз.\u003Cbr\u003EВозраст до 18 лет (безопасности применения у детей не установлена).\u003Cbr\u003EПериод грудного вскармливания."},{"name":"Состав","value":"Активные вещества: леводопа 250 мг, карбидопа 25 мг; вспомогательные вещества: повидон К-30 9 мг, тальк 6 мг, магния стеарат 5,5 мг, крахмал (сухой) 12 мг, кремния диоксид коллоидный 5 мг, целлюлоза микрокристалллическая 85,5 мг."},{"name":"Действующее вещество","value":"Леводопа+Карбидопа","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["27144131:36089532"]}}},{"name":"Способ применения и дозы","value":"Внутрь, с небольшим количеством пищи или после еды, запивая водой и не разжевывая. Поскольку существует конкуренция между ароматическими аминокислотами и леводопой при всасывании, во время применения препарата следует избегать потребления большого количества белков.\u003Cbr\u003EСредняя суточная доза карбидопы, необходимая для подавления периферического превращения леводопы, составляет 70-100 мг. Превышение 200 мг карбидопы не влечет за собой дальнейшего усиления терапевтического эффекта. Суточная доза леводопы не должна превышать 2000 мг.\u003Cbr\u003EНачальная доза - по 1/2 таблетки 2 раза в день, при необходимости можно увеличивать на Уг таблетки в день. Как правило, в начале заместительной терапии дневная доза не должна превышать 3-х таблеток в день (по 1-й таблетке 3 раза в день). Применение в этой дозе рекомендуют в начале лечения тяжелых случаев паркинсонизма. Суточная доза препарата в виде исключения может быть увеличена при монотерапии, но не должна превышать 8 таблеток (по 1-й таблетке 8 раз в день). Применение в количестве более чем 6 таблеток в день должно проводиться с большой осторожностью.\u003Cbr\u003EТидомет Форте при замене леводопы\u003Cbr\u003EПием леводопы прекращают за 12 часов до начала лечения препаратом Тидомет Форте, а в случае приема пролонгированных форм левокарбидопы - за 24 часа. Доза препарата Тидомет Форте в этом случае должна составлять не более 20 % от прежней дозы леводопы. Поддерживающая доза составляет 3-6 таблеток в сутки для большинства пациентов."},{"name":"Побочные действия","value":"Наиболее часто - дискинезии, включая непроизвольные движения (в том числе хореиформные, дистонические), а также тошнота.\u003Cbr\u003EРанними признаками, на основании которых может быть принято решение об отмене препарата являются мышечные подергивания и блефароспазм.\u003Cbr\u003EДругие побочные действия:\u003Cbr\u003EСо стороны нервной системы: психотические реакции, включая бред, галлюцинации и параноидальное мышление, злокачественный нейролептический синдром (см. \"Особые указания\"), эпизоды брадикинезии (синдром \"включения-выключения\"), ажитация, парестезии, головокружение, сонливость, нарушение сна, включая кошмарные сновидения, бессонницу; спутанность сознания, головная боль, депрессия (в т.ч. с суицидальными намерениями), деменция, патологические пристрастия, повышение либидо. Сообщалось о развитии судорог, однако причинно-следственная связь с приемом препарата не установлена.\u003Cbr\u003EСо стороны пищеварительной системы: рвота, анорексия, диарея, запор, диспепсия, сухость слизистой оболочки полости рта, изменение вкуса, потемнение слюны, кровотечение из желудочно-кишечного тракта, язва двенадцатиперстной кишки. Со стороны сердечно-сосудистой системы: аритмия и/или ощущение сердцебиения, ортостатические реакции, включая снижение или повышение артериального, давления (АД), обморок; флебит.\u003Cbr\u003EСо стороны системы кроветворения: лейкопения, тромбоцитопения, анемия (в том числе гемолитическая), агранулоцитоз.\u003Cbr\u003EАллергические реакции: ангионевротический отек, крапивница, кожный зуд, геморрагический васкулит (пурпура Шенлейна-Геноха), буллезные высыпания (в том числе реакции сходные с пузырчаткой).\u003Cbr\u003EСо стороны дыхательной системы: одышка, инфекции верхних дыхательных путей. Со стороны кожных покровов: кожная сыпь, повышенная потливость, потемнение пота, алопеция.\u003Cbr\u003EСо стороны мочевыделительной системы: инфекции мочевыводящих путей, частое мочеиспускание, потемнение мочи.\u003Cbr\u003EИзменение лабораторных показателей: снижение гемоглобина и гематокрита, повышение активности аланинаминотрансферазы (AJIT), аспартатаминотрансферазы (ACT), лактатдегидрогеназы, щелочной фосфатазы, гипербилирубинемия, повышение азота мочевины, положительная проба Кумбса, гипергликемия, лейкоцитурия, бактериурия и гематурия.\u003Cbr\u003EПрочие: боль в груди, астения.\u003Cbr\u003EНиже перечислены другие побочные реакции, которые наблюдались при применении только леводопы, а значит, они могут отмечаться при применении препарата Тидомет Форте:\u003Cbr\u003EСо стороны сердечно-сосудистой системы: инфаркт миокарда.\u003Cbr\u003EСо стороны пищеварительной системы: желудочно-кишечная боль, дисфагия, слюнотечение, метеоризм, бруксизм, ощущение жжения языка, изжога, икота.\u003Cbr\u003EСо стороны обмена веществ: отеки, снижение или повышение массы тела.\u003Cbr\u003EСо стороны нервной системы: атаксия, экстрапирамидные расстройства, падения, тревога, нарушение походки, нервозность, снижение остроты мышления, снижение памяти, дезориентация, эйфория, блефароспазм, тризм, усиление тремора, оцепенение, подергивание мышц, активизация латентного синдрома Горнера, периферическая нейропатия.\u003Cbr\u003EСо стороны дыхательной системы: боль в глотке, кашель.\u003Cbr\u003EСо стороны кожных покровов: злокачественная меланома, \"приливы\" крови.\u003Cbr\u003EСо стороны органов чувств: окулогирный криз, диплопия, нарушение зрения, мидриаз. Со стороны мочеполовой системы: задержка мочи, недержание мочи, приапизм.\u003Cbr\u003EПрочие: абдоминальная боль, усталость, слабость, боль в нижних конечностях, одышка, недомогание, охриплость голоса, возбуждение.\u003Cbr\u003EСо стороны лабораторных показателей: лейкопения, гипокалиемия, гиперкреатининемия и гиперурикемия, протеинурия и глюкозурия."},{"name":"Фармакологическое действие","value":"Леводопа представляет собой аминокислоту, образующуюся из L-тирозина. Дофамин образуется непосредственно из леводопы при участии цитоплазматического фермента -декарбоксилазы ароматических L-аминокислот. Конечным результатом влияния дофамина является угнетение нейрональной активности в полосатом теле головного мозга. Леводопа быстро декарбоксилируется в периферических тканях под влиянием зависимой от пиридоксина декарбоксилазы ароматических L-аминокислот, превращаясь в дофамин, который, однако, через гематоэнцефалический барьер не проникает. Карбидопа ингибирует процесс декарбоксилирования леводопы в периферических тканях, при этом не проникает через гематоэнцефалический барьер и не влияет на превращение леводопы в дофамин в центральной нервной системе. Таким образом, комбинация карбидопы и леводопы позволяет увеличивать количество леводопы, поступающее в головной мозг. При совместном приеме внутрь карбидопа удваивает биодоступность леводопы. Введение карбидопы никогда не приводит к полному угнетению декарбоксилазы ароматических L-аминокислот."},{"name":"Фармакологическая группа","value":"противопаркинсоническое средство комбинированное (дофамина предшественник+декарбоксилазы периферической ингибитор)"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"В сухом, защищенном от света месте, при температуре не выше 30°С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Лечение: промывание желудка, тщательное наблюдение и ЭКГ-контроль для своевременного выявления аритмии; при необходимости - антиаритмическая терапия."},{"name":"Применение при беременности и кормлении грудью","value":"Влияние препарата на течение беременности у женщин неизвестно. В экспериментальных исследованиях выявлено, что комбинация леводопы и карбидопы вызывает висцеральные и скелетные изменения у животных. Поэтому применение препарата возможно только в случае, когда ожидаемая польза терапии для матери превосходит потенциальный риск для плода.\u003Cbr\u003EНеизвестно, выделяются ли с грудным молоком леводопа и карбидопа. Имеется одно сообщение об экскреции леводопы с грудным молоком у кормящей матери с болезнью Паркинсона. Поэтому из-за возможного серьезного вредного воздействия препарата на ребенка и с учетом важности проведения терапии для матери, при необходимости применения препарата в период лактации следует либо прекратить грудное вскармливание, либо отменить препарат."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"При назначении препарата Тидомет Форте рекомендуется воздержаться от вождения автомобиля и управления механизмами, требующими повышенного внимания и скорости психомоторных реакций."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EПрепарат назначают с осторожностью при эрозивно-язвенных поражениях желудка и/или двенадцатиперстной кишки, эпилептических припадках в анамнезе, инфаркте миокарда с нарушениями ритма сердца в анамнезе, сердечной недостаточности, заболеваниях эндокринной системы (в том числе сахарном диабете), бронхиальной астме, психических нарушениях, а также при тяжелых нарушениях функции печени и почек."},{"name":"Взаимодействие","value":"- одновременное применение с гипотензивными средствами требует специального внимания в связи с опасностью постуральной гипотензии;\u003Cbr\u003E- при одновременном применении леводопы с ингибиторами моноаминооксидазы (МАО) (за исключением ингибиторов МАО-В) возможны нарушения кровообращения (прием ингибиторов МАО должен быть прекращен за 2 нед). Это связано с накоплением под влиянием леводопы дофамина и норэпинефрина, метаболизм которых замедлен ингибиторами МАО, и высокой вероятностью развития ажитации, повышения артериального давления (АД), тахикардии, покраснения лица и головокружения;\u003Cbr\u003E- при совместном применении с трициклическими антидепрессантами может возникнуть артериальная гипертензия и дискинезия, а также уменьшение биодоступности леводопы;\u003Cbr\u003E- при совместном применении с агонистами D2-дофаминовых рецепторов (производные фенотиазина, бутирофенона), а также с изониазидом возможно уменьшение терапевтического эффекта леводопы;\u003Cbr\u003E- может усиливать действие адреномиметиков, в связи с чем рекомендуется снизить их дозу. При одновременном применении леводопы с β-адреномиметиками, средствами для ингаляционной анестезии возможно увеличение риска развития нарушений сердечного ритма;\u003Cbr\u003E- при применении амантадина с леводопой отмечается потенцирующий эффект;\u003Cbr\u003E- метилдопа и леводопа могут потенцировать побочные эффекты друг друга;\u003Cbr\u003E- пиридоксин является кофактором декарбоксилазы ароматических L-аминокислот -фермента, ответственного за периферическое декарбоксилирование леводопы и образование дофамина. При его назначении больным, получающим леводопу (без ингибиторов декарбоксилазы ароматических L-аминокислот), отмечается усиление периферического метаболизма леводопы и меньшее ее количество проникает через гематоэнцефалический барьер. Таким образом, пиридоксин уменьшает терапевтический эффект леводопы, если дополнительно не назначаются ингибиторы периферической декарбоксилазы ароматических L-аминокислот;\u003Cbr\u003E- при дополнительном назначении ингибиторов декарбоксилазы ароматических L-аминокислот суточную дозу леводопы можно уменьшить на 70-80% при сохранении того же клинического результата\u003Cbr\u003E- при совместном применении с диазепамом, фенитоином, клонидином, производными тиоксантена, папаверином, резерпином, м-холиноблокаторами возможно уменьшение противопаркинсонического действия;\u003Cbr\u003E- при одновременном применении с препаратами лития (Li+) повышается риск развития дискинезий и галлюцинаций;\u003Cbr\u003E- соли железа могут снижать биодоступность леводопы и карбидопы; клиническая значимость такого взаимодействия неизвестна;\u003Cbr\u003E- хотя метоклопрамид повышает биодоступность леводопы, ускоряя опорожнение желудка, тем не менее, он может неблагоприятно повлиять на контроль над заболеванием за счет его антагонизма с дофаминовыми рецепторами."},{"name":"Источник","value":"\u003Ca href=\"https://www.vidal.ru\" target=\"_blank\"\u003EСправочник лекарственных препаратов Видаль<\u002Fa\u003E"},{"name":"Регистрационный номер","value":"П N012502/01"},{"name":"Дата государственной регистрации","value":"20.07.2018"},{"name":"Владелец регистрационного удостоверения","value":"Torrent Pharmaceuticals Ltd","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["34324371:35649313","7893318:16002754"]}}},{"name":"Изготовитель","value":"Torrent Pharmaceuticals Ltd"},{"name":"Фасовщик","value":"Torrent Pharmaceuticals Ltd"},{"name":"Страна бренда","value":"Индия"},{"name":"Страна-производитель","value":"Индия"},{"name":"Название препарата","value":"Тидомет","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["17796364:18025869"]}}},{"name":"Срок годности","value":"35 мес."}]}},"fullSpecsGrouped":{"3062382248963951545":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"головной мозг, нервная система"},{"name":"Назначение","value":"болезнь Паркинсона, паркинсонизм"},{"name":"Показания к применению","value":"Лечение болезни Паркинсона и синдрома паркинсонизма."},{"name":"Противопоказания","value":"Противопоказания:\u003Cbr\u003EПовышенная чувствительность к леводопе, карбидопе или любым вспомогательным компонентам препарата.\u003Cbr\u003EОдновременный прием с неселективными ингибиторами МАО. Необходимо прекратить применение данных препаратов не менее, чем за 2 недели до начала применения препарата Тидомет Форте (за исключением селективных ингибиторов МАО-В (например, селегилина гидрохлорида)).\u003Cbr\u003EЗакрытоугольная глаукома.\u003Cbr\u003EПациенты с подозрением на недиагностированные кожные заболевания или меланомой в анамнезе (поскольку леводопа может стимулировать развитие злокачественной меланомы).\u003Cbr\u003EТяжелый психоз.\u003Cbr\u003EВозраст до 18 лет (безопасности применения у детей не установлена).\u003Cbr\u003EПериод грудного вскармливания."},{"name":"Состав","value":"Активные вещества: леводопа 250 мг, карбидопа 25 мг; вспомогательные вещества: повидон К-30 9 мг, тальк 6 мг, магния стеарат 5,5 мг, крахмал (сухой) 12 мг, кремния диоксид коллоидный 5 мг, целлюлоза микрокристалллическая 85,5 мг."},{"name":"Действующее вещество","value":"Леводопа+Карбидопа"},{"name":"Способ применения и дозы","value":"Внутрь, с небольшим количеством пищи или после еды, запивая водой и не разжевывая. Поскольку существует конкуренция между ароматическими аминокислотами и леводопой при всасывании, во время применения препарата следует избегать потребления большого количества белков.\u003Cbr\u003EСредняя суточная доза карбидопы, необходимая для подавления периферического превращения леводопы, составляет 70-100 мг. Превышение 200 мг карбидопы не влечет за собой дальнейшего усиления терапевтического эффекта. Суточная доза леводопы не должна превышать 2000 мг.\u003Cbr\u003EНачальная доза - по 1/2 таблетки 2 раза в день, при необходимости можно увеличивать на Уг таблетки в день. Как правило, в начале заместительной терапии дневная доза не должна превышать 3-х таблеток в день (по 1-й таблетке 3 раза в день). Применение в этой дозе рекомендуют в начале лечения тяжелых случаев паркинсонизма. Суточная доза препарата в виде исключения может быть увеличена при монотерапии, но не должна превышать 8 таблеток (по 1-й таблетке 8 раз в день). Применение в количестве более чем 6 таблеток в день должно проводиться с большой осторожностью.\u003Cbr\u003EТидомет Форте при замене леводопы\u003Cbr\u003EПием леводопы прекращают за 12 часов до начала лечения препаратом Тидомет Форте, а в случае приема пролонгированных форм левокарбидопы - за 24 часа. Доза препарата Тидомет Форте в этом случае должна составлять не более 20 % от прежней дозы леводопы. Поддерживающая доза составляет 3-6 таблеток в сутки для большинства пациентов."},{"name":"Побочные действия","value":"Наиболее часто - дискинезии, включая непроизвольные движения (в том числе хореиформные, дистонические), а также тошнота.\u003Cbr\u003EРанними признаками, на основании которых может быть принято решение об отмене препарата являются мышечные подергивания и блефароспазм.\u003Cbr\u003EДругие побочные действия:\u003Cbr\u003EСо стороны нервной системы: психотические реакции, включая бред, галлюцинации и параноидальное мышление, злокачественный нейролептический синдром (см. \"Особые указания\"), эпизоды брадикинезии (синдром \"включения-выключения\"), ажитация, парестезии, головокружение, сонливость, нарушение сна, включая кошмарные сновидения, бессонницу; спутанность сознания, головная боль, депрессия (в т.ч. с суицидальными намерениями), деменция, патологические пристрастия, повышение либидо. Сообщалось о развитии судорог, однако причинно-следственная связь с приемом препарата не установлена.\u003Cbr\u003EСо стороны пищеварительной системы: рвота, анорексия, диарея, запор, диспепсия, сухость слизистой оболочки полости рта, изменение вкуса, потемнение слюны, кровотечение из желудочно-кишечного тракта, язва двенадцатиперстной кишки. Со стороны сердечно-сосудистой системы: аритмия и/или ощущение сердцебиения, ортостатические реакции, включая снижение или повышение артериального, давления (АД), обморок; флебит.\u003Cbr\u003EСо стороны системы кроветворения: лейкопения, тромбоцитопения, анемия (в том числе гемолитическая), агранулоцитоз.\u003Cbr\u003EАллергические реакции: ангионевротический отек, крапивница, кожный зуд, геморрагический васкулит (пурпура Шенлейна-Геноха), буллезные высыпания (в том числе реакции сходные с пузырчаткой).\u003Cbr\u003EСо стороны дыхательной системы: одышка, инфекции верхних дыхательных путей. Со стороны кожных покровов: кожная сыпь, повышенная потливость, потемнение пота, алопеция.\u003Cbr\u003EСо стороны мочевыделительной системы: инфекции мочевыводящих путей, частое мочеиспускание, потемнение мочи.\u003Cbr\u003EИзменение лабораторных показателей: снижение гемоглобина и гематокрита, повышение активности аланинаминотрансферазы (AJIT), аспартатаминотрансферазы (ACT), лактатдегидрогеназы, щелочной фосфатазы, гипербилирубинемия, повышение азота мочевины, положительная проба Кумбса, гипергликемия, лейкоцитурия, бактериурия и гематурия.\u003Cbr\u003EПрочие: боль в груди, астения.\u003Cbr\u003EНиже перечислены другие побочные реакции, которые наблюдались при применении только леводопы, а значит, они могут отмечаться при применении препарата Тидомет Форте:\u003Cbr\u003EСо стороны сердечно-сосудистой системы: инфаркт миокарда.\u003Cbr\u003EСо стороны пищеварительной системы: желудочно-кишечная боль, дисфагия, слюнотечение, метеоризм, бруксизм, ощущение жжения языка, изжога, икота.\u003Cbr\u003EСо стороны обмена веществ: отеки, снижение или повышение массы тела.\u003Cbr\u003EСо стороны нервной системы: атаксия, экстрапирамидные расстройства, падения, тревога, нарушение походки, нервозность, снижение остроты мышления, снижение памяти, дезориентация, эйфория, блефароспазм, тризм, усиление тремора, оцепенение, подергивание мышц, активизация латентного синдрома Горнера, периферическая нейропатия.\u003Cbr\u003EСо стороны дыхательной системы: боль в глотке, кашель.\u003Cbr\u003EСо стороны кожных покровов: злокачественная меланома, \"приливы\" крови.\u003Cbr\u003EСо стороны органов чувств: окулогирный криз, диплопия, нарушение зрения, мидриаз. Со стороны мочеполовой системы: задержка мочи, недержание мочи, приапизм.\u003Cbr\u003EПрочие: абдоминальная боль, усталость, слабость, боль в нижних конечностях, одышка, недомогание, охриплость голоса, возбуждение.\u003Cbr\u003EСо стороны лабораторных показателей: лейкопения, гипокалиемия, гиперкреатининемия и гиперурикемия, протеинурия и глюкозурия."},{"name":"Фармакологическое действие","value":"Леводопа представляет собой аминокислоту, образующуюся из L-тирозина. Дофамин образуется непосредственно из леводопы при участии цитоплазматического фермента -декарбоксилазы ароматических L-аминокислот. Конечным результатом влияния дофамина является угнетение нейрональной активности в полосатом теле головного мозга. Леводопа быстро декарбоксилируется в периферических тканях под влиянием зависимой от пиридоксина декарбоксилазы ароматических L-аминокислот, превращаясь в дофамин, который, однако, через гематоэнцефалический барьер не проникает. Карбидопа ингибирует процесс декарбоксилирования леводопы в периферических тканях, при этом не проникает через гематоэнцефалический барьер и не влияет на превращение леводопы в дофамин в центральной нервной системе. Таким образом, комбинация карбидопы и леводопы позволяет увеличивать количество леводопы, поступающее в головной мозг. При совместном приеме внутрь карбидопа удваивает биодоступность леводопы. Введение карбидопы никогда не приводит к полному угнетению декарбоксилазы ароматических L-аминокислот."},{"name":"Фармакологическая группа","value":"противопаркинсоническое средство комбинированное (дофамина предшественник+декарбоксилазы периферической ингибитор)"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"В сухом, защищенном от света месте, при температуре не выше 30°С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Лечение: промывание желудка, тщательное наблюдение и ЭКГ-контроль для своевременного выявления аритмии; при необходимости - антиаритмическая терапия."},{"name":"Применение при беременности и кормлении грудью","value":"Влияние препарата на течение беременности у женщин неизвестно. В экспериментальных исследованиях выявлено, что комбинация леводопы и карбидопы вызывает висцеральные и скелетные изменения у животных. Поэтому применение препарата возможно только в случае, когда ожидаемая польза терапии для матери превосходит потенциальный риск для плода.\u003Cbr\u003EНеизвестно, выделяются ли с грудным молоком леводопа и карбидопа. Имеется одно сообщение об экскреции леводопы с грудным молоком у кормящей матери с болезнью Паркинсона. Поэтому из-за возможного серьезного вредного воздействия препарата на ребенка и с учетом важности проведения терапии для матери, при необходимости применения препарата в период лактации следует либо прекратить грудное вскармливание, либо отменить препарат."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"При назначении препарата Тидомет Форте рекомендуется воздержаться от вождения автомобиля и управления механизмами, требующими повышенного внимания и скорости психомоторных реакций."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EПрепарат назначают с осторожностью при эрозивно-язвенных поражениях желудка и/или двенадцатиперстной кишки, эпилептических припадках в анамнезе, инфаркте миокарда с нарушениями ритма сердца в анамнезе, сердечной недостаточности, заболеваниях эндокринной системы (в том числе сахарном диабете), бронхиальной астме, психических нарушениях, а также при тяжелых нарушениях функции печени и почек."},{"name":"Взаимодействие","value":"- одновременное применение с гипотензивными средствами требует специального внимания в связи с опасностью постуральной гипотензии;\u003Cbr\u003E- при одновременном применении леводопы с ингибиторами моноаминооксидазы (МАО) (за исключением ингибиторов МАО-В) возможны нарушения кровообращения (прием ингибиторов МАО должен быть прекращен за 2 нед). Это связано с накоплением под влиянием леводопы дофамина и норэпинефрина, метаболизм которых замедлен ингибиторами МАО, и высокой вероятностью развития ажитации, повышения артериального давления (АД), тахикардии, покраснения лица и головокружения;\u003Cbr\u003E- при совместном применении с трициклическими антидепрессантами может возникнуть артериальная гипертензия и дискинезия, а также уменьшение биодоступности леводопы;\u003Cbr\u003E- при совместном применении с агонистами D2-дофаминовых рецепторов (производные фенотиазина, бутирофенона), а также с изониазидом возможно уменьшение терапевтического эффекта леводопы;\u003Cbr\u003E- может усиливать действие адреномиметиков, в связи с чем рекомендуется снизить их дозу. При одновременном применении леводопы с β-адреномиметиками, средствами для ингаляционной анестезии возможно увеличение риска развития нарушений сердечного ритма;\u003Cbr\u003E- при применении амантадина с леводопой отмечается потенцирующий эффект;\u003Cbr\u003E- метилдопа и леводопа могут потенцировать побочные эффекты друг друга;\u003Cbr\u003E- пиридоксин является кофактором декарбоксилазы ароматических L-аминокислот -фермента, ответственного за периферическое декарбоксилирование леводопы и образование дофамина. При его назначении больным, получающим леводопу (без ингибиторов декарбоксилазы ароматических L-аминокислот), отмечается усиление периферического метаболизма леводопы и меньшее ее количество проникает через гематоэнцефалический барьер. Таким образом, пиридоксин уменьшает терапевтический эффект леводопы, если дополнительно не назначаются ингибиторы периферической декарбоксилазы ароматических L-аминокислот;\u003Cbr\u003E- при дополнительном назначении ингибиторов декарбоксилазы ароматических L-аминокислот суточную дозу леводопы можно уменьшить на 70-80% при сохранении того же клинического результата\u003Cbr\u003E- при совместном применении с диазепамом, фенитоином, клонидином, производными тиоксантена, папаверином, резерпином, м-холиноблокаторами возможно уменьшение противопаркинсонического действия;\u003Cbr\u003E- при одновременном применении с препаратами лития (Li+) повышается риск развития дискинезий и галлюцинаций;\u003Cbr\u003E- соли железа могут снижать биодоступность леводопы и карбидопы; клиническая значимость такого взаимодействия неизвестна;\u003Cbr\u003E- хотя метоклопрамид повышает биодоступность леводопы, ускоряя опорожнение желудка, тем не менее, он может неблагоприятно повлиять на контроль над заболеванием за счет его антагонизма с дофаминовыми рецепторами."},{"name":"Источник","value":"\u003Ca href=\"https://www.vidal.ru\" target=\"_blank\"\u003EСправочник лекарственных препаратов Видаль<\u002Fa\u003E"},{"name":"Регистрационный номер","value":"П N012502/01"},{"name":"Дата государственной регистрации","value":"20.07.2018"},{"name":"Владелец регистрационного удостоверения","value":"Torrent Pharmaceuticals Ltd"},{"name":"Изготовитель","value":"Torrent Pharmaceuticals Ltd"},{"name":"Фасовщик","value":"Torrent Pharmaceuticals Ltd"},{"name":"Страна бренда","value":"Индия"},{"name":"Страна-производитель","value":"Индия"},{"name":"Название препарата","value":"Тидомет"},{"name":"Срок годности","value":"35 мес."}]}],"transitionId":"tr_9582717868664797958"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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696 ₽

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ЕАПТЕКА
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    на основе 10 оценок
    Цена 150 ₽
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  • Наком таб., 250 мг+25 мг, 100 шт.
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    Наком таб., 250 мг+25 мг, 100 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 1 422 ₽
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  • Армадин лонг таб. с пролонг. высвоб. п/о плен., 375 мг, 30 шт.
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    Армадин лонг таб. с пролонг. высвоб. п/о плен., 375 мг, 30 шт.

    Рейтинг товара: 4.8 из 5
    на основе 53 оценки
    Цена 718 ₽
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  • Леводопа/Карбидопа/Энтакапон-Тева таб. п/о, 100 мг+25 мг+200 мг, 30 шт.
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    Леводопа/Карбидопа/Энтакапон-Тева таб. п/о, 100 мг+25 мг+200 мг, 30 шт.

    Рейтинг товара: 4.3 из 5
    на основе 15 оценок
    Цена 3 639 ₽
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  • Прамипексол таб., 0.25 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-dic2syzimar/toggleWishlist":{"skuId":"101703977118","productId":1698374632,"offerId":"Q_BVt2Bfxu27PakdNMR2fA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ29vHiY3k1fs1EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI6MfsqQYQnpGe8PoCGISpsggg7dnBBw==","sign":"fJ1uz2yBze24UyIYd4wyRnAOcvGTUrwnHn+71N3YtcM="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-dic2syzimar/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Прамипексол таб., 0.25 мг, 30 шт.

    Рейтинг товара: 4.8 из 5
    на основе 23 оценки
    Цена 246 ₽
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  • Ламитор таб., 25 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-8hv3b46k8q2/toggleWishlist":{"skuId":"265151650","productId":1404748462,"offerId":"FUxnnSqpEUCjdPtiawROcQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ29vHiY3k1fs1EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIroXrnQUQosm3fhjC3dAHIO3ZwQc=","sign":"4I8KNFt/KHFwCCQ7/Qk0YP/nPnnziZ/iST0rffXH9y4="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-8hv3b46k8q2/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Ламитор таб., 25 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 263 ₽
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-8hv3b46k8q2/addToCartButton":{"offerId":"FUxnnSqpEUCjdPtiawROcQ","skuId":"265151650","pendingCartItem":{"productId":1404748462,"offerId":"FUxnnSqpEUCjdPtiawROcQ","showPlaceId":"OTNDnItfwRMjN9MRHuEMMu4V0osPKVn0cOGHlCnoEegAr-IrV93yNqRYToPsLqw4KJUw-Eg7aSU9edTgkNCpTPZgSisNHfNdUHXopv8eh98U4ubAj1C90-t0R5zfYlCVtak_kyyLAZnL4YGyFNJobBWGSqXPMFiM414UqMGHhWL_GaNZAZ9LPkTAe1VXv7uw8DDbxJ3DHew60eKtw8xdYg,,","feeShow":"OTNDnItfwRMjN9MRHuEMMu4V0osPKVn0cOGHlCnoEegAr-IrV93yNqRYToPsLqw4KJUw-Eg7aSU9edTgkNCpTPZgSisNHfNdUHXopv8eh98U4ubAj1C90-t0R5zfYlCVtak_kyyLAZnL4YGyFNJobBWGSqXPMFiM414UqMGHhWL_GaNZAZ9LPkTAe1VXv7uw8DDbxJ3DHew60eKtw8xdYg,,","skuId":"265151650","shopId":55106433,"price":{"applicablePriceDiscounts":[],"value":"263","currency":"RUR"},"hid":"15756525","name":"Ламитор таб., 25 мг, 30 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  • Бривиак таб. п/о плен., 25 мг, 56 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-5oeivfgb84q/toggleWishlist":{"skuId":"228018734","productId":1404748495,"offerId":"GQQ6gh7b9eRZqzsDIDWZrQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ29vHiY3k1fs1EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIz4XrnQUQrpTdbBig2q4IIO3ZwQc=","sign":"8qGsV2CKoxFVBBwjkEV0CYa3vYpZo9jt5rZZYo8+X+0="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-5oeivfgb84q/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Бривиак таб. п/о плен., 25 мг, 56 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 5 698 ₽
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  • Проноран таб. с контрол. высвоб. п/о, 50 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-m949xc4od0b/toggleWishlist":{"skuId":"101618541704","productId":1697874464,"offerId":"Jp91ohtXBAod-LfpceAoaw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ29vHiY3k1fs1EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIoITOqQYQiMm/x/oCGKXe0Acg7dnBBw==","sign":"d6HBbEx+XThB50ImohNpBUVdKtskZnucDLHYwQLHAi0="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-m949xc4od0b/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Проноран таб. с контрол. высвоб. п/о, 50 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 4 оценки
    Цена 439 ₽
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  • Метостабил таб. п/о плен., 125 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-hp37h4q51r/toggleWishlist":{"skuId":"101813288735","productId":835941480,"offerId":"FyoblG8eP9yWwa18DvEI8A","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ29vHiY3k1fs1EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI6OjNjgMQn/6tpPsCGISpsggg7dnBBw==","sign":"9+gPtN98pWjE8URBn4cpED5+vFUj4ycWuAW6hkiaVWg="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-hp37h4q51r/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Метостабил таб. п/о плен., 125 мг, 30 шт.

    Рейтинг товара: 4 из 5
    на основе 5 оценок
    Цена 215 ₽
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  • Сердолект таб. п/о, 4 мг, 30 шт.
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    Сердолект таб. п/о, 4 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 4 оценки
    Цена 1 651 ₽
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Инструкция

Показания к применению

Лечение болезни Паркинсона и синдрома паркинсонизма.

Противопоказания

Противопоказания:
Повышенная чувствительность к леводопе, карбидопе или любым вспомогательным компонентам препарата.
Одновременный прием с неселективными ингибиторами МАО. Необходимо прекратить применение данных препаратов не менее, чем за 2 недели до начала применения препарата Тидомет Форте (за исключением селективных ингибиторов МАО-В (например, селегилина гидрохлорида)).
Закрытоугольная глаукома.
Пациенты с подозрением на недиагностированные кожные заболевания или меланомой в анамнезе (поскольку леводопа может стимулировать развитие злокачественной меланомы).
Тяжелый психоз.
Возраст до 18 лет (безопасности применения у детей не установлена).
Период грудного вскармливания.

Способ применения и дозы

Внутрь, с небольшим количеством пищи или после еды, запивая водой и не разжевывая. Поскольку существует конкуренция между ароматическими аминокислотами и леводопой при всасывании, во время применения препарата следует избегать потребления большого количества белков.
Средняя суточная доза карбидопы, необходимая для подавления периферического превращения леводопы, составляет 70-100 мг. Превышение 200 мг карбидопы не влечет за собой дальнейшего усиления терапевтического эффекта. Суточная доза леводопы не должна превышать 2000 мг.
Начальная доза - по 1/2 таблетки 2 раза в день, при необходимости можно увеличивать на Уг таблетки в день. Как правило, в начале заместительной терапии дневная доза не должна превышать 3-х таблеток в день (по 1-й таблетке 3 раза в день). Применение в этой дозе рекомендуют в начале лечения тяжелых случаев паркинсонизма. Суточная доза препарата в виде исключения может быть увеличена при монотерапии, но не должна превышать 8 таблеток (по 1-й таблетке 8 раз в день). Применение в количестве более чем 6 таблеток в день должно проводиться с большой осторожностью.
Тидомет Форте при замене леводопы
Пием леводопы прекращают за 12 часов до начала лечения препаратом Тидомет Форте, а в случае приема пролонгированных форм левокарбидопы - за 24 часа. Доза препарата Тидомет Форте в этом случае должна составлять не более 20 % от прежней дозы леводопы. Поддерживающая доза составляет 3-6 таблеток в сутки для большинства пациентов.
Полная инструкция
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Тидомет форте таб.
Тидомет форте таб., 250 мг+25 мг, 100 шт.
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3 вопроса
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