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Описание

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Орлистат-акрихин капс., 120 мг, 42 шт.

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Коротко о товаре

Артикул Маркета
3123150839
Тип препарата
Назначение
Действующее вещество
Возраст
от 12 лет
Инструкция
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карбоксиметилкрахмал натрия (натрия крахмала гликолят) — 38 мг; натрия лаурилсульфат — 10 мг; повидон — 10 мг; тальк — 2,4 мг;\u003Cbr/\u003E"},{"name":"Действующее вещество","value":"Орлистат","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["27144131:28710734"]}}},{"name":"Способ применения и дозы","value":"Внутрь, запивая водой, с каждым основным приемом пищи (непосредственно до еды, во время еды или не позднее чем через 1 час после еды).\u003Cbr\u003EДлительная терапия пациентов с ожирением (индекс массы тела ≥30 кг/м²) или пациентов с избыточной массой тела (индекс массы тела ≥28 кг/м²), имеющих ассоциированные с ожирением факторы риска, в сочетании с умеренно гипокалорийной диетой:\u003Cbr\u003Eу взрослых и детей старше 12 лет рекомендованная доза орлистата составляет одну капсулу 120 мг 3 раза в сутки.\u003Cbr\u003EВ комбинации с гипогликемическими препаратами (метформин, производные сульфонилмочевины и/или инсулин) и/или умеренно гипокалорийной диетой пациентам с сахарным диабетом 2 типа с избыточной массой тела или ожирением:\u003Cbr\u003Eу взрослых рекомендованная доза орлистата составляет одну капсулу 120 мг 3 раза в сутки.\u003Cbr\u003EЕсли прием пищи пропускают или пища не содержит жира, то прием препарата Орлистат-Акрихин также можно пропустить.\u003Cbr\u003EПрепарат следует принимать в сочетании со сбалансированной, умеренно гипокалорийной диетой, содержащей не более 30% калоража в виде жиров. Суточное потребление жиров, углеводов и белков необходимо распределять на три основные приема.\u003Cbr\u003EУвеличение дозы орлистата свыше рекомендованной (120 мг 3 раза в сутки) не приводит к усилению его терапевтического эффекта.\u003Cbr\u003EЭффективность и безопасность препарата Орлистат-Акрихин у пациентов с нарушением функции печени и/или почек, а также у пациентов пожилого и детского возраста (младше 12 лет не исследовались).\u003Cbr\u003EУ пожилых пациентов, пациентов с нарушениями функции печени и почек коррекции дозы не требуется."},{"name":"Побочные действия","value":"Для описания частоты побочных реакций используются следующие категории: очень часто (\u003E 1/10), часто (\u003E 1/100, \u003C 1/10), нечасто (\u003E 1/1 000, \u003C 1/100), редко (\u003E 1/10 000, \u003C 1/1 000) и очень редко (\u003C1/10 000), включая отдельные случаи.\u003Cbr\u003EПобочные реакции на орлистат возникали главным образом со стороны желудочно-кишечного тракта и были обусловлены фармакологическим действием препарата, препятствующего всасыванию жиров пищи. Частота развития нежелательных явлений уменьшалась при длительном использовании орлистата.\u003Cbr\u003EУказанные ниже нежелательные явления возникали с частотой ˃2% и инцидентностью ≥1% по сравнению с плацебо.\u003Cbr\u003EИнфекционные и паразитарные заболевания: очень часто – грипп.\u003Cbr\u003EНарушения со стороны обмена веществ и питания: очень часто – гипогликемия*.\u003Cbr\u003EНарушения психики: часто – тревога.\u003Cbr\u003EНарушения со стороны нервной системы: очень часто – головная боль.\u003Cbr\u003EНарушения со стороны дыхательной системы, органов грудной клетки и средостения: очень часто – инфекции верхних дыхательных путей; часто – инфекции нижних дыхательных путей.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта: очень часто – боли или дискомфорт в животе, маслянистые выделения из прямой кишки, выделение газов с некоторым количеством отделяемого, императивные позывы на дефекацию, стеаторея, метеоризм, жидкий стул, учащение дефекации; часто – боли или дискомфорт в прямой кишке, «мягкий» стул, недержание кала, поражение зубов, поражение десен, вздутие живота*.\u003Cbr\u003EНарушения со стороны почек и мочевыводящих путей: часто – инфекции мочевыводящих путей.\u003Cbr\u003EНарушения со стороны половых органов и молочной железы: часто – нерегулярные менструации.\u003Cbr\u003EОбщие расстройства и нарушения в месте введения: часто – слабость.\u003Cbr\u003EУ пациентов с сахарным диабетом 2 типа характер и частота нежелательных явлений были сопоставимы с таковыми у лиц без сахарного диабета с избыточной массой тела и ожирением.\u003Cbr\u003E*Единственными новыми побочными явлениями у пациентов с ожирением и сахарным диабетом 2 типа гипогликемические состояния (очень часто) и вздутие живота (часто), возникавшие с частотой ˃2% и инцидентностью ≥1% по сравнению с плацебо.\u003Cbr\u003EЧастота нарушений со стороны желудочно-кишечного тракта увеличивается при повышении содержания жира в питании. Пациентов следует информировать о возможности возникновения побочных реакций со стороны желудочно-кишечного тракта и обучить, как устранять их путем лучшего соблюдения диеты, особенно в отношении количества содержащегося в ней жира. Применение диеты с низким содержанием жира уменьшает вероятность побочных действий со стороны желудочно-кишечного тракта и тем самым помогает пациентам контролировать и регулировать потребление жиров.\u003Cbr\u003EКак правило, указанные побочные реакции являются слабо выраженными и транзиторными. Они возникали на ранних этапах лечения (в первые 3 месяца), причем, у большинства пациентов было не более одного эпизода таких реакций.\u003Cbr\u003EВ 4-х летнем клиническом исследовании общий профиль безопасности не отличался от такового, полученного в 1- и 2-летних исследованиях. При этом общая частота возникновения нежелательных явлений со стороны желудочно-кишечного тракта ежегодно уменьшалась на протяжении 4-х летнего периода приема препарата."},{"name":"Фармакологическое действие","value":"Специфический ингибитор желудочно-кишечных липаз. Образует ковалентную связь с активным сериновым участком желудочной и панкреатической липаз в просвете желудка и тонкого кишечника. Инактивированный фермент теряет способность расщеплять жиры пищи, поступающие в форме ТГ. Нерасщепленные ТГ не всасываются, и возникающее вследствие этого уменьшение поступления калорий в организм приводит к уменьшению массы тела. Увеличивает концентрацию жира в каловых массах через 24-48 ч после приема. Обеспечивает эффективный контроль массы тела, уменьшение депо жира."},{"name":"Фармакологическая группа","value":"ингибиторы липазы ЖКТ"},{"name":"Форма выпуска","value":"капсулы"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 12 лет"},{"name":"Условия хранения","value":"В оригинальной упаковке для защиты от света, при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Случаи передозировки не описаны.\u003Cbr\u003EОднократный прием 800 мг орлистата или его многократный прием в дозе до 400 мг 3 раза в сутки в течение 15 дней людьми с нормальной массой тела и с ожирением не сопровождался значимыми побочными явлениями.\u003Cbr\u003EЕсли выявлена значительная передозировка орлистата, следует наблюдать за состоянием пациента в течение 24 ч. По данным исследований у животных и человека, системные эффекты, связанные с липазоингибирующими свойствами орлистата, должны быть быстро обратимыми."},{"name":"Применение при беременности и кормлении грудью","value":"Доклинические исследования не выявили тератогенного и эмбриотоксического эффекта орлистата. Однако, в связи с отсутствием клинических данных о применении у беременных, орлистат противопоказан при беременности.\u003Cbr\u003EПоскольку неизвестно, проникает ли орлистат в грудное молоко, он противопоказан в период грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Не оказывает влияние на способность к управлению транспортными средствами и обслуживанию движущихся механизмов."},{"name":"Особые указания","value":"Орлистат применяется для длительного контроля массы тела (снижение массы тела, поддержание ее на соответствующем уровне и предотвращение повторного прибавления массы тела).\u003Cbr\u003EЗа счет снижения массы тела на фоне приема орлистата, возможно улучшение углеводного обмена у пациентов с сахарным диабетом 2 типа, что может позволить уменьшить дозу гипогликемических препаратов.\u003Cbr\u003EПациент должен находиться на сбалансированной умеренно низкокалорийной диете, содержащей не более 30% калорий в виде жиров. Рекомендуется, чтобы такая диета была богата фруктами и овощами. Суточное потребление жиров должно быть распределено между тремя основными приемами пищи. Диета с низким содержанием жиров уменьшает вероятность развития нежелательных явлений со стороны желудочно-кишечного тракта. При применении орлистата наблюдались случаи ректального кровотечения. При появлении тяжелых и/или стойких симптомов кровотечения необходимо провести дополнительное обследование.\u003Cbr\u003EЕсли через 12 недель терапии не произошло снижения массы тела, как минимум, на 5%, прием орлистата следует прекратить.\u003Cbr\u003EЛечение не должно продолжаться более 2 лет.\u003Cbr\u003EПри появлении таких симптомов, как слабость, утомляемость, повышение температуры тела, желтуха и потемнение мочи, необходимо проконсультироваться с врачом для исключения нарушения функции печени.\u003Cbr\u003EПрименение орлистата может сопровождаться гипероксалурией и оксалатной нефропатией, которая иногда приводит к почечной недостаточности. Повышенному риску подвергаются пациенты с сопутствующими хроническими заболеваниями почек и/или обезвоживанием.\u003Cbr\u003EОрлистат может снижать всасывание антиретровирусных препаратов для лечения ВИЧ и отрицательно сказываться на их эффективности.\u003Cbr\u003EС осторожностью:\u003Cbr\u003EСопутствующая терапия циклоспорином, варфарином или другими пероральными антикоагулянтами."},{"name":"Взаимодействие","value":"При одновременном применении орлистата и циклоспорина возможно снижение концентрации циклоспорина в плазме крови, что может привести к снижению иммуносупрессивной эффективности циклоспорина. Таким образом, сопутствующее применение орлистата и циклоспорина не рекомендуется. Тем не менее, если такое сопутствующее применение является необходимым, рекомендуется проводить более частый контроль концентрации циклоспорина в плазме крови как при одновременном применении его с орлистатом, так и после прекращения применения орлистата. Концентрацию циклоспорина в плазме крови следует контролировать до ее стабилизации. При одновременном применении орлистата с амиодароном рекомендуется клиническое наблюдение и мониторинг ЭКГ, так как возможно снижение концентрации амиодарона в плазме крови.\u003Cbr\u003EПри одновременном приеме орлистата и варфарина или других антикоагулянтов, может наблюдаться снижение концентрации протромбина и повышение МНО, что приводит к изменению гемостатических показателей. Необходимо мониторировать показатели МНО при сопутствующей терапии варфарином или другими пероральными антикоагулянтами. Орлистат может уменьшать абсорбцию жирорастворимых витаминов A, D, Е, К и бета-каротина. Если показан прием поливитаминов, то их следует принимать не ранее, чем через 2 часа после приема орлистата или перед сном.\u003Cbr\u003EОрлистат может снижать всасывание противоэпилептических препаратов, что может привести к возникновению судорог.\u003Cbr\u003EИмеются сообщения о нескольких случаях снижения эффективности антиретровирусных препаратов для лечения ВИЧ, антидепрессантов, нейролептиков (включая литий) и бензодиазепинов, которое совпадало с началом лечения орлистатом у пациентов с ранее достигнутым адекватным контролем соответствующего состояния. У таких пациентов лечение орлистатом следует начинать после тщательной оценки соотношения польза/риск.\u003Cbr\u003EС учетом отсутствия исследований фармакокинетического взаимодействия, совместного назначения орлистата и акарбозы необходимо избегать.\u003Cbr\u003EОрлистат способен опосредованно снижать эффективность пероральных контрацептивов, что в отдельных случаях может привести к незапланированной беременности. Рекомендуется применять дополнительный метод контрацепции также в случае развития тяжелой диареи.\u003Cbr\u003EПри одновременном приеме с левотироксином натрия, в связи с уменьшением всасывания неорганического йода и/или левотироксина натрия, может развиться гипотиреоз и/или снижение контроля гипотиреоза.\u003Cbr\u003EНе выявлено лекарственного взаимодействия с амитриптилином, аторвастатином, бигуанидами, дигоксином, фибратами, флуоксетином, лозартаном, фенитоином, фентермином, правастатином, нифедипином, сибутрамином и этанолом."},{"name":"Регистрационный номер","value":"ЛП-001455"},{"name":"Дата государственной регистрации","value":"30.08.2019"},{"name":"Владелец регистрационного удостоверения","value":"Polpharma","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["34324371:35649313","7893318:16002745"]}}},{"name":"Изготовитель","value":"Polpharma"},{"name":"Страна бренда","value":"Польша"},{"name":"Страна-производитель","value":"Польша"},{"name":"Название препарата","value":"Орлистат","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["17796364:18014575"]}}},{"name":"Срок годности","value":"24 мес."}]}},"fullSpecsGrouped":{"15773343924274017421":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"пищеварительная система"},{"name":"Назначение","value":"избыточная масса тела, похудение"},{"name":"Показания к применению","value":"Длительная терапия пациентов с ожирением (индекс массы тела ≥30 кг/м2) или пациентов с избыточной массой тела (индекс массы тела ≥28 кг/м2), имеющих ассоциированные с ожирением факторы риска, в сочетании с умеренно гипокалорийной диетой.\u003Cbr\u003EВ комбинации с гипогликемическими препаратами (метформин, производные сульфонилмочевины и/или инсулин) и/или умеренно гипокалорийной диетой пациентам с сахарным диабетом 2 типа с избыточной массой тела или ожирением."},{"name":"Противопоказания","value":"Повышенная чувствительность к орлистату или любому из вспомогательных веществ препарата;\u003Cbr\u003Eсиндром хронической мальабсорбции;\u003Cbr\u003Eхолестаз;\u003Cbr\u003Eбеременность и период грудного вскармливания;\u003Cbr\u003Eдетский возраст до 12 лет."},{"name":"Состав","value":"Действующее вещество: орлистат - 120 мг\u003Cbr\u003EВспомогательные вещества: МКЦ — 59,6 мг; карбоксиметилкрахмал натрия (натрия крахмала гликолят) — 38 мг; натрия лаурилсульфат — 10 мг; повидон — 10 мг; тальк — 2,4 мг;\u003Cbr/\u003E"},{"name":"Действующее вещество","value":"Орлистат"},{"name":"Способ применения и дозы","value":"Внутрь, запивая водой, с каждым основным приемом пищи (непосредственно до еды, во время еды или не позднее чем через 1 час после еды).\u003Cbr\u003EДлительная терапия пациентов с ожирением (индекс массы тела ≥30 кг/м²) или пациентов с избыточной массой тела (индекс массы тела ≥28 кг/м²), имеющих ассоциированные с ожирением факторы риска, в сочетании с умеренно гипокалорийной диетой:\u003Cbr\u003Eу взрослых и детей старше 12 лет рекомендованная доза орлистата составляет одну капсулу 120 мг 3 раза в сутки.\u003Cbr\u003EВ комбинации с гипогликемическими препаратами (метформин, производные сульфонилмочевины и/или инсулин) и/или умеренно гипокалорийной диетой пациентам с сахарным диабетом 2 типа с избыточной массой тела или ожирением:\u003Cbr\u003Eу взрослых рекомендованная доза орлистата составляет одну капсулу 120 мг 3 раза в сутки.\u003Cbr\u003EЕсли прием пищи пропускают или пища не содержит жира, то прием препарата Орлистат-Акрихин также можно пропустить.\u003Cbr\u003EПрепарат следует принимать в сочетании со сбалансированной, умеренно гипокалорийной диетой, содержащей не более 30% калоража в виде жиров. Суточное потребление жиров, углеводов и белков необходимо распределять на три основные приема.\u003Cbr\u003EУвеличение дозы орлистата свыше рекомендованной (120 мг 3 раза в сутки) не приводит к усилению его терапевтического эффекта.\u003Cbr\u003EЭффективность и безопасность препарата Орлистат-Акрихин у пациентов с нарушением функции печени и/или почек, а также у пациентов пожилого и детского возраста (младше 12 лет не исследовались).\u003Cbr\u003EУ пожилых пациентов, пациентов с нарушениями функции печени и почек коррекции дозы не требуется."},{"name":"Побочные действия","value":"Для описания частоты побочных реакций используются следующие категории: очень часто (\u003E 1/10), часто (\u003E 1/100, \u003C 1/10), нечасто (\u003E 1/1 000, \u003C 1/100), редко (\u003E 1/10 000, \u003C 1/1 000) и очень редко (\u003C1/10 000), включая отдельные случаи.\u003Cbr\u003EПобочные реакции на орлистат возникали главным образом со стороны желудочно-кишечного тракта и были обусловлены фармакологическим действием препарата, препятствующего всасыванию жиров пищи. Частота развития нежелательных явлений уменьшалась при длительном использовании орлистата.\u003Cbr\u003EУказанные ниже нежелательные явления возникали с частотой ˃2% и инцидентностью ≥1% по сравнению с плацебо.\u003Cbr\u003EИнфекционные и паразитарные заболевания: очень часто – грипп.\u003Cbr\u003EНарушения со стороны обмена веществ и питания: очень часто – гипогликемия*.\u003Cbr\u003EНарушения психики: часто – тревога.\u003Cbr\u003EНарушения со стороны нервной системы: очень часто – головная боль.\u003Cbr\u003EНарушения со стороны дыхательной системы, органов грудной клетки и средостения: очень часто – инфекции верхних дыхательных путей; часто – инфекции нижних дыхательных путей.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта: очень часто – боли или дискомфорт в животе, маслянистые выделения из прямой кишки, выделение газов с некоторым количеством отделяемого, императивные позывы на дефекацию, стеаторея, метеоризм, жидкий стул, учащение дефекации; часто – боли или дискомфорт в прямой кишке, «мягкий» стул, недержание кала, поражение зубов, поражение десен, вздутие живота*.\u003Cbr\u003EНарушения со стороны почек и мочевыводящих путей: часто – инфекции мочевыводящих путей.\u003Cbr\u003EНарушения со стороны половых органов и молочной железы: часто – нерегулярные менструации.\u003Cbr\u003EОбщие расстройства и нарушения в месте введения: часто – слабость.\u003Cbr\u003EУ пациентов с сахарным диабетом 2 типа характер и частота нежелательных явлений были сопоставимы с таковыми у лиц без сахарного диабета с избыточной массой тела и ожирением.\u003Cbr\u003E*Единственными новыми побочными явлениями у пациентов с ожирением и сахарным диабетом 2 типа гипогликемические состояния (очень часто) и вздутие живота (часто), возникавшие с частотой ˃2% и инцидентностью ≥1% по сравнению с плацебо.\u003Cbr\u003EЧастота нарушений со стороны желудочно-кишечного тракта увеличивается при повышении содержания жира в питании. Пациентов следует информировать о возможности возникновения побочных реакций со стороны желудочно-кишечного тракта и обучить, как устранять их путем лучшего соблюдения диеты, особенно в отношении количества содержащегося в ней жира. Применение диеты с низким содержанием жира уменьшает вероятность побочных действий со стороны желудочно-кишечного тракта и тем самым помогает пациентам контролировать и регулировать потребление жиров.\u003Cbr\u003EКак правило, указанные побочные реакции являются слабо выраженными и транзиторными. Они возникали на ранних этапах лечения (в первые 3 месяца), причем, у большинства пациентов было не более одного эпизода таких реакций.\u003Cbr\u003EВ 4-х летнем клиническом исследовании общий профиль безопасности не отличался от такового, полученного в 1- и 2-летних исследованиях. При этом общая частота возникновения нежелательных явлений со стороны желудочно-кишечного тракта ежегодно уменьшалась на протяжении 4-х летнего периода приема препарата."},{"name":"Фармакологическое действие","value":"Специфический ингибитор желудочно-кишечных липаз. Образует ковалентную связь с активным сериновым участком желудочной и панкреатической липаз в просвете желудка и тонкого кишечника. Инактивированный фермент теряет способность расщеплять жиры пищи, поступающие в форме ТГ. Нерасщепленные ТГ не всасываются, и возникающее вследствие этого уменьшение поступления калорий в организм приводит к уменьшению массы тела. Увеличивает концентрацию жира в каловых массах через 24-48 ч после приема. Обеспечивает эффективный контроль массы тела, уменьшение депо жира."},{"name":"Фармакологическая группа","value":"ингибиторы липазы ЖКТ"},{"name":"Форма выпуска","value":"капсулы"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 12 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"В оригинальной упаковке для защиты от света, при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Случаи передозировки не описаны.\u003Cbr\u003EОднократный прием 800 мг орлистата или его многократный прием в дозе до 400 мг 3 раза в сутки в течение 15 дней людьми с нормальной массой тела и с ожирением не сопровождался значимыми побочными явлениями.\u003Cbr\u003EЕсли выявлена значительная передозировка орлистата, следует наблюдать за состоянием пациента в течение 24 ч. По данным исследований у животных и человека, системные эффекты, связанные с липазоингибирующими свойствами орлистата, должны быть быстро обратимыми."},{"name":"Применение при беременности и кормлении грудью","value":"Доклинические исследования не выявили тератогенного и эмбриотоксического эффекта орлистата. Однако, в связи с отсутствием клинических данных о применении у беременных, орлистат противопоказан при беременности.\u003Cbr\u003EПоскольку неизвестно, проникает ли орлистат в грудное молоко, он противопоказан в период грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Не оказывает влияние на способность к управлению транспортными средствами и обслуживанию движущихся механизмов."},{"name":"Особые указания","value":"Орлистат применяется для длительного контроля массы тела (снижение массы тела, поддержание ее на соответствующем уровне и предотвращение повторного прибавления массы тела).\u003Cbr\u003EЗа счет снижения массы тела на фоне приема орлистата, возможно улучшение углеводного обмена у пациентов с сахарным диабетом 2 типа, что может позволить уменьшить дозу гипогликемических препаратов.\u003Cbr\u003EПациент должен находиться на сбалансированной умеренно низкокалорийной диете, содержащей не более 30% калорий в виде жиров. Рекомендуется, чтобы такая диета была богата фруктами и овощами. Суточное потребление жиров должно быть распределено между тремя основными приемами пищи. Диета с низким содержанием жиров уменьшает вероятность развития нежелательных явлений со стороны желудочно-кишечного тракта. При применении орлистата наблюдались случаи ректального кровотечения. При появлении тяжелых и/или стойких симптомов кровотечения необходимо провести дополнительное обследование.\u003Cbr\u003EЕсли через 12 недель терапии не произошло снижения массы тела, как минимум, на 5%, прием орлистата следует прекратить.\u003Cbr\u003EЛечение не должно продолжаться более 2 лет.\u003Cbr\u003EПри появлении таких симптомов, как слабость, утомляемость, повышение температуры тела, желтуха и потемнение мочи, необходимо проконсультироваться с врачом для исключения нарушения функции печени.\u003Cbr\u003EПрименение орлистата может сопровождаться гипероксалурией и оксалатной нефропатией, которая иногда приводит к почечной недостаточности. Повышенному риску подвергаются пациенты с сопутствующими хроническими заболеваниями почек и/или обезвоживанием.\u003Cbr\u003EОрлистат может снижать всасывание антиретровирусных препаратов для лечения ВИЧ и отрицательно сказываться на их эффективности.\u003Cbr\u003EС осторожностью:\u003Cbr\u003EСопутствующая терапия циклоспорином, варфарином или другими пероральными антикоагулянтами."},{"name":"Взаимодействие","value":"При одновременном применении орлистата и циклоспорина возможно снижение концентрации циклоспорина в плазме крови, что может привести к снижению иммуносупрессивной эффективности циклоспорина. Таким образом, сопутствующее применение орлистата и циклоспорина не рекомендуется. Тем не менее, если такое сопутствующее применение является необходимым, рекомендуется проводить более частый контроль концентрации циклоспорина в плазме крови как при одновременном применении его с орлистатом, так и после прекращения применения орлистата. Концентрацию циклоспорина в плазме крови следует контролировать до ее стабилизации. При одновременном применении орлистата с амиодароном рекомендуется клиническое наблюдение и мониторинг ЭКГ, так как возможно снижение концентрации амиодарона в плазме крови.\u003Cbr\u003EПри одновременном приеме орлистата и варфарина или других антикоагулянтов, может наблюдаться снижение концентрации протромбина и повышение МНО, что приводит к изменению гемостатических показателей. Необходимо мониторировать показатели МНО при сопутствующей терапии варфарином или другими пероральными антикоагулянтами. Орлистат может уменьшать абсорбцию жирорастворимых витаминов A, D, Е, К и бета-каротина. Если показан прием поливитаминов, то их следует принимать не ранее, чем через 2 часа после приема орлистата или перед сном.\u003Cbr\u003EОрлистат может снижать всасывание противоэпилептических препаратов, что может привести к возникновению судорог.\u003Cbr\u003EИмеются сообщения о нескольких случаях снижения эффективности антиретровирусных препаратов для лечения ВИЧ, антидепрессантов, нейролептиков (включая литий) и бензодиазепинов, которое совпадало с началом лечения орлистатом у пациентов с ранее достигнутым адекватным контролем соответствующего состояния. У таких пациентов лечение орлистатом следует начинать после тщательной оценки соотношения польза/риск.\u003Cbr\u003EС учетом отсутствия исследований фармакокинетического взаимодействия, совместного назначения орлистата и акарбозы необходимо избегать.\u003Cbr\u003EОрлистат способен опосредованно снижать эффективность пероральных контрацептивов, что в отдельных случаях может привести к незапланированной беременности. Рекомендуется применять дополнительный метод контрацепции также в случае развития тяжелой диареи.\u003Cbr\u003EПри одновременном приеме с левотироксином натрия, в связи с уменьшением всасывания неорганического йода и/или левотироксина натрия, может развиться гипотиреоз и/или снижение контроля гипотиреоза.\u003Cbr\u003EНе выявлено лекарственного взаимодействия с амитриптилином, аторвастатином, бигуанидами, дигоксином, фибратами, флуоксетином, лозартаном, фенитоином, фентермином, правастатином, нифедипином, сибутрамином и этанолом."},{"name":"Регистрационный номер","value":"ЛП-001455"},{"name":"Дата государственной регистрации","value":"30.08.2019"},{"name":"Владелец регистрационного удостоверения","value":"Polpharma"},{"name":"Изготовитель","value":"Polpharma"},{"name":"Страна бренда","value":"Польша"},{"name":"Страна-производитель","value":"Польша"},{"name":"Название препарата","value":"Орлистат"},{"name":"Срок годности","value":"24 мес."}]}],"transitionId":"tr_16688897457308407272"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

Где купить

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1 689 ₽

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    Рейтинг товара: 4.6 из 5
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    на основе 1200 оценок
    Цена 2 809 ₽
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  • Орсотен Слим капс., 60 мг, 42 шт.
    –2 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-8a5p4x4tr0p/toggleWishlist":{"skuId":"457101321","productId":1400799471,"offerId":"_cVv_Y9INXAGtsdSV1CEPw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ3vGrj/6AtJAFEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYI74H6mwUQiaD72QEYoMTeByDa2cEH","sign":"k9eYES9Pd995Jgj4V+lr2SRVTIWtIHgCzrb9JQoWlVs="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-8a5p4x4tr0p/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Орсотен Слим капс., 60 мг, 42 шт.

    Рейтинг товара: 4.1 из 5
    на основе 17 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 337 ₽ вместо 1 365
    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Слим капс., 60 мг, 42 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  • Орлистат-Акрихин капс., 60 мг, 42 шт.
    –1 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-e2v8u1cbmh/toggleWishlist":{"skuId":"227814360","productId":1778171018,"offerId":"PSGfr-WVBSMieiv1srA84A","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ3vGrj/6AtJAFEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIivnyzwYQ2NfQbBi53dAHINrZwQc=","sign":"IuzNGsVgSMAON1f2W/45m7z9G2FMrKhxDLtIwQ8BMvY="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-e2v8u1cbmh/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Орлистат-Акрихин капс., 60 мг, 42 шт.

    Рейтинг товара: 4.6 из 5
    на основе 73 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 817 ₽ вместо 825
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  • Орлистат-акрихин капс., 120 мг, 84 шт.
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    Орлистат-акрихин капс., 120 мг, 84 шт.

    Рейтинг товара: 4.9 из 5
    на основе 47 оценок
    Цена 3 185 ₽
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  • Листата таб. п/о плен., 120 мг, 20 шт.
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    Листата таб. п/о плен., 120 мг, 20 шт.

    Рейтинг товара: 4.7 из 5
    на основе 52 оценки
    Цена 1 096 ₽
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  • Орсотен капс., 120 мг, 21 шт.
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    Орсотен капс., 120 мг, 21 шт.

    Рейтинг товара: 4.7 из 5
    на основе 30 оценок
    Цена 1 035 ₽
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  • Ксеникал капс., 120 мг, 21 шт.
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    Ксеникал капс., 120 мг, 21 шт.

    Рейтинг товара: 4.8 из 5
    на основе 27 оценок
    Цена 1 012 ₽
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  • Орлистат капс., 60 мг, 42 шт.
    –21 %
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    Орлистат капс., 60 мг, 42 шт.

    Рейтинг товара: 4.9 из 5
    на основе 8 оценок
    Цена 864 ₽ вместо 1 094
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  • Редуксин капс., 10 мг+158.5 мг, 30 шт.
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    Редуксин капс., 10 мг+158.5 мг, 30 шт.

    Рейтинг товара: 4.9 из 5
    на основе 24 оценки
    Цена 2 749 ₽
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  • Орлистат-Алиум капс., 120 мг, 21 шт.
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    Орлистат-Алиум капс., 120 мг, 21 шт.

    Рейтинг товара: 4.7 из 5
    на основе 12 оценок
    Цена 1 233 ₽
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Инструкция

Показания к применению

Длительная терапия пациентов с ожирением (индекс массы тела ≥30 кг/м2) или пациентов с избыточной массой тела (индекс массы тела ≥28 кг/м2), имеющих ассоциированные с ожирением факторы риска, в сочетании с умеренно гипокалорийной диетой.
В комбинации с гипогликемическими препаратами (метформин, производные сульфонилмочевины и/или инсулин) и/или умеренно гипокалорийной диетой пациентам с сахарным диабетом 2 типа с избыточной массой тела или ожирением.

Противопоказания

Повышенная чувствительность к орлистату или любому из вспомогательных веществ препарата;
синдром хронической мальабсорбции;
холестаз;
беременность и период грудного вскармливания;
детский возраст до 12 лет.

Способ применения и дозы

Внутрь, запивая водой, с каждым основным приемом пищи (непосредственно до еды, во время еды или не позднее чем через 1 час после еды).
Длительная терапия пациентов с ожирением (индекс массы тела ≥30 кг/м²) или пациентов с избыточной массой тела (индекс массы тела ≥28 кг/м²), имеющих ассоциированные с ожирением факторы риска, в сочетании с умеренно гипокалорийной диетой:
у взрослых и детей старше 12 лет рекомендованная доза орлистата составляет одну капсулу 120 мг 3 раза в сутки.
В комбинации с гипогликемическими препаратами (метформин, производные сульфонилмочевины и/или инсулин) и/или умеренно гипокалорийной диетой пациентам с сахарным диабетом 2 типа с избыточной массой тела или ожирением:
у взрослых рекомендованная доза орлистата составляет одну капсулу 120 мг 3 раза в сутки.
Если прием пищи пропускают или пища не содержит жира, то прием препарата Орлистат-Акрихин также можно пропустить.
Препарат следует принимать в сочетании со сбалансированной, умеренно гипокалорийной диетой, содержащей не более 30% калоража в виде жиров. Суточное потребление жиров, углеводов и белков необходимо распределять на три основные приема.
Увеличение дозы орлистата свыше рекомендованной (120 мг 3 раза в сутки) не приводит к усилению его терапевтического эффекта.
Эффективность и безопасность препарата Орлистат-Акрихин у пациентов с нарушением функции печени и/или почек, а также у пациентов пожилого и детского возраста (младше 12 лет не исследовались).
У пожилых пациентов, пациентов с нарушениями функции печени и почек коррекции дозы не требуется.
Полная инструкция
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Орлистат-акрихин капс.
Орлистат-акрихин капс., 120 мг, 42 шт.
5.0
(10)
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5 вопросов
Инструкция

1 689 ₽

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5.0
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У продавца:10 оценок·1 отзыв
У всех продавцов:118 оценок·22 отзыва
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user avatar
4 месяца назад • Алла Белюшина • Куплен на Маркете
Достоинства: Мне очень помогает
Недостатки: не нашла
Комментарий: Рекомендую к приобратению
Посмотреть все отзывы на Маркете
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