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Описание

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Амлодипин-АЛСИ таб., 10 мг, 30 шт.

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5.0
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Коротко о товаре

Артикул Маркета
3123247258
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
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6,9 мг или 13,8 мг, что соответствует 5 мг или 10 мг амлодипина;\u003Cbr /\u003Eвспомогательные вещества: Лудипресс (лактозы моногидрат - 85,7/171,4 мг, повидон - 3,2/6,4 мг, кросповидон - 3,2/6,4 мг) - 92,1/184,2 мг, кальция стеарат - 1,0/2,0 мг.\u003Cbr /\u003E"},{"name":"Действующее вещество","value":"Амлодипин","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["27144131:28709386"]}}},{"name":"Способ применения и дозы","value":"Препарат принимают внутрь, один раз в сутки, запивая необходимым количеством воды (100 мл).\u003Cbr /\u003EПри артериальной гипертензии и стенокардии начальная доза обычно составляет 5 мг, в зависимости от индивидуальной реакции пациента ее можно увеличить до максимальной суточной дозы, составляющей 10 мг.\u003Cbr /\u003EПрименение у пожилых пациентов\u003Cbr /\u003EУ пациентов пожилого возраста препарат рекомендуется применять в средней терапевтической дозе, коррекция дозы препарата не требуется.\u003Cbr /\u003EПрименение у пациентов с нарушенной функцией печени\u003Cbr /\u003EНесмотря на то, что Т1/2 амлодипина, как и всех БМКК, увеличивается у пациентов с нарушениями функции печени, коррекции дозы препарата у данной категории пациентов обычно не требуется (см. раздел \"Особые указания\").\u003Cbr /\u003EПрименение у пациентов с нарушенной функцией почек\u003Cbr /\u003EУ пациентов с нарушениями функции почек рекомендуется применять амлодипин в обычных дозах, однако необходимо учитывать возможное незначительное увеличение Т1/2.\u003Cbr /\u003EНе требуется коррекция дозы препарата Амлодипин-АЛСИ при одновременном применении с тиазидными диуретиками, бета-адреноблокаторами и ингибиторами АПФ.\u003Cbr /\u003E"},{"name":"Побочные действия","value":"Со стороны сердечно-сосудистой системы: возможны периферические отеки, сердцебиение, гиперемия кожных покровов; при применении в высоких дозах - артериальная гипотензия, аритмии, одышка.\u003Cbr\u003EСо стороны пищеварительной системы: тошнота, боли в животе; редко - гиперплазия десен.\u003Cbr\u003EСо стороны ЦНС: возможны головная боль, усталость, сонливость, головокружение.\u003Cbr\u003EАллергические реакции: кожная сыпь, зуд."},{"name":"Фармакологическое действие","value":"Амлодипин - селективный блокатор кальциевых каналов II класса. Антигипертензивное действие обусловлено прямым расслабляющим влиянием на гладкие мышцы сосудов. Предполагается, что антиангинальное действие амлодипина связано с его способностью расширять периферические артериолы; это приводит к уменьшению ОПСС, рефлекторная тахикардия при этом не возникает. В результате происходит снижение потребности миокарда в кислороде и потребления энергии сердечной мышцей. С другой стороны, амлодипин, по-видимому, вызывает расширение коронарных артерий крупного калибра и коронарных артериол как интактных, так и ишемизированных участков миокарда. Это обеспечивает поступление кислорода к миокарду при спазмах коронарных артерий."},{"name":"Фармакологическая группа","value":"блокатор \"медленных\" кальциевых каналов"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"Хранить при температуре не выше 25 °С."},{"name":"Передозировка","value":"Симптомы: выраженное снижение АД с возможным развитием рефлекторной тахикардии и чрезмерной периферической вазодилатации (существует вероятность появления выраженной и стойкой артериальной гипотензии, в том числе с развитием шока и летального исхода).\u003Cbr /\u003EЛечение: промывание желудка, назначение активированного угля (особенно в первые 2 ч после передозировки), горизонтальное положение с низким изголовьем, активное поддержание функции сердечно-сосудистой системы, мониторинг показателей работы сердца и легких, контроль объема циркулирующей крови и диуреза. Для восстановления тонуса сосудов - применение сосудосуживающих средств (при отсутствии противопоказаний к их применению); для устранения последствий блокады кальциевых каналов - внутривенное введение глюконата кальция. Гемодиализ неэффективен.\u003Cbr /\u003E"},{"name":"Применение при беременности и кормлении грудью","value":"Безопасность применения препарата Амлодипин-АЛСИ во время беременности не установлена, поэтому применение во время беременности возможно только в случае, когда польза для матери превышает риск для плода и новорожденного.\u003Cbr\u003EДанные, свидетельствующие о выделении амлодипина в грудное молоко, отсутствуют. Однако известно, что другие БМКК (производные дигидропиридина) выделяются в грудное молоко. В связи с этим при необходимости применения препарата Амлодипин-АЛСИ в период лактации следует решить вопрос о прекращении грудного вскармливания.\u003Cbr\u003EНе было выявлено влияния амлодипина на фертильность в ходе большинства исследований на крысах. В одном из исследований на самцах крыс сообщалось о побочном влиянии на фертильность."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Хотя на фоне применения препарата Амлодипин-АЛСИ какого-либо отрицательного влияния на способность управлять автотранспортом или другими сложными механизмами не наблюдалось, однако, вследствие возможного чрезмерного снижения АД, развития головокружения, сонливости и других побочных реакций, следует соблюдать осторожность в перечисленных ситуациях, особенно в начале лечения и при изменении режима дозирования (увеличения дозы)."},{"name":"Особые указания","value":"С осторожностью применяют при нарушениях функции печени, при стенозе устья аорты, при хронической сердечной недостаточности. Пациентам с нарушениями функции почек, а также пациентам пожилого возраста снижения дозы не требуется. Возможно применение амлодипина для лечения пациентов с дилатационной (неишемической) кардиомиопатией, сопровождающейся тяжелой формой хронической сердечной недостаточности."},{"name":"Взаимодействие","value":"Амлодипин может безопасно применяться для лечения артериальной гипертензии вместе с тиазидными диуретиками, альфа-адреноблокаторами, бета-адреноблокаторами или ингибиторами АПФ. У пациентов со стабильной стенокардией амлодипин можно комбинировать с другими антиангинальными средствами, например, с нитратами пролонгированного или короткого действия, бета-адреноблокаторами.\u003Cbr /\u003EВ отличие от других БМКК клинически значимого взаимодействия амлодипина (III поколение БМКК) не было обнаружено при совместном применении с нестероидными противовоспалительными препаратами (НПВП), в том числе и с индометацином.\u003Cbr /\u003EВозможно усиление антиангинального и гипотензивного действия БМКК при совместном применении с тиазидными и \"петлевыми\" диуретиками, ингибиторами АПФ, бета-адреноблокаторами и нитратами, а также усиление их гипотензивного действия при совместном применении с альфа1-адреноблокаторами, нейролептиками.\u003Cbr /\u003EХотя при изучении амлодипина отрицательного инотропного действия обычно не наблюдали, тем не менее, некоторые БМКК могут усиливать выраженность отрицательного инотропного действия антиаритмических средств, вызывающих удлинение интервала QT (например, амиодарон и хинидин).\u003Cbr /\u003EАмлодипин может также безопасно применяться одновременно с антибиотиками и гипогликемическими средствами для приема внутрь.\u003Cbr /\u003EОднократный прием силденафила в дозе 100 мг у пациентов с эссенциальной гипертензией не оказывает влияния на параметры фармакокинетики амлодипина. Повторное применение амлодипина в дозе 10 мг и аторвастатина в дозе 80 мг не сопровождается значительными изменениями показателей фармакокинетики аторвастатина.\u003Cbr /\u003EОдновременное многократное применение амлодипина в дозе 10 мг и симвастатина в дозе 80 мг приводит к повышению экспозиции симвастатина на 77%. В таких случаях следует ограничить дозу симвастатина до 20 мг.\u003Cbr /\u003EАмлодипин при однократном и повторном применении в дозе 10 мг не влияет на фармакокинетику этанола.\u003Cbr /\u003EПротивовирусные препараты (например, ритонавир) увеличивают плазменные концентрации БМКК, в том числе и амлодипина.\u003Cbr /\u003EНейролептики и изофлуран усиливают гипотензивное действие производных дигидропиридина.\u003Cbr /\u003EПрепараты кальция могут уменьшить эффект БМКК.\u003Cbr /\u003EПри совместном применении БМКК с препаратами лития (для амлодипина данные отсутствуют), возможно усиление проявлений нейротоксичности последних (тошнота, рвота, диарея, атаксия, тремор, шум в ушах).\u003Cbr /\u003EИсследования одновременного применения амлодипина и циклоспорина у здоровых добровольцев и всех групп пациентов, за исключением пациентов после трансплантации почки, не проводились. Различные исследования взаимодействия амлодипина с циклоспорином у пациентов после трансплантации почки показывают, что применение данной комбинации может не приводить к какому-либо эффекту, либо повышать минимальную концентрацию циклоспорина в различной степени до 40%. Следует принимать во внимание эти данные и контролировать концентрацию циклоспорина у этой группы пациентов при одновременном применении циклоспорина и амлодипина.\u003Cbr /\u003EАмлодипин не оказывает влияния на концентрацию в сыворотке крови дигоксина и его почечный клиренс.\u003Cbr /\u003EАмлодипин не оказывает существенного влияния на действие варфарина (протромбиновое время).\u003Cbr /\u003EЦиметидин не влияет на фармакокинетику амлодипина.\u003Cbr /\u003EВ исследованиях in vitro амлодипин не влияет на связывание с белками плазмы крови дигоксина, фенитоина, варфарина и индометацина.\u003Cbr /\u003EОдновременный однократный прием 240 мл грейпфрутового сока и 10 мг амлодипина внутрь не сопровождается существенным изменением фархмакокинетики амлодипина. Тем не менее, не рекомендуется применять грейпфрутовый сок и амлодипин одновременно, так как при генетическом полиморфизме изофермента CYP3A4 возможно повышение биодоступности амлодипина и, вследствие этого, усиление гипотензивного эффекта.\u003Cbr /\u003EОднократный прием алюминий/магнийсодержащих антацидов не оказывает существенного влияния на фармакокинетику амлодипина.\u003Cbr /\u003EПри одновременном применении дилтиазема (ингибитор изофермента CYP3A4) в дозе 180 мг и амлодипина в дозе 5 мг у пациентов пожилого возраста (от 69 до 87 лет) с артериальной гипертензией отмечается повышение системной экспозиции амлодипина на 57%.\u003Cbr /\u003EОдновременное применение амлодипина и эритромицина у здоровых добровольцев (от 18 до 43 лет) не приводит к значительным изменениям экспозиции амлодипина (увеличение площади под кривой \"концентрация-время\" AUC на 22%). Несмотря на то, что клиническое значение этих эффектов до конца не ясно, они могут быть более ярко выражены у пожилых пациентов.\u003Cbr /\u003EМощные ингибиторы изофермента CYP3A4 (например, кетоконазол, итраконазол) могут приводить к увеличению концентрации амлодипина в плазме крови в большей степени, чем дилтиазем. Следует с осторожностью применять амлодипин и ингибиторы изофермента CYP3A4.\u003Cbr /\u003EУ пациентов, принимающих одновременно кларитромицин (ингибитор изофермента CYP3A4) и амлодипин, повышен риск снижения артериального давления. Пациентам, принимающим такую комбинацию, рекомендуется находиться под тщательным медицинским наблюдением.\u003Cbr /\u003EДанных о влиянии индукторов изофермента CYP3A4 на фармакокинетику амлодипина нет. Следует тщательно контролировать АД при одновременном применении амлодипина и индукторов изофермента CYP3A4.\u003Cbr /\u003EПри одновременном применении такролимуса с амлодипином есть риск увеличения концентрации такролимуса в плазме крови. Для того, чтобы избежать токсичности такролимуса при одновременном применении с амлодипином, следует контролировать концентрацию такролимуса в плазме крови пациентов и корректировать дозу такролимуса в случае необходимости.\u003Cbr /\u003E"},{"name":"Регистрационный номер","value":"ЛСР-009349/09"},{"name":"Дата государственной регистрации","value":"08.02.2019"},{"name":"Владелец регистрационного удостоверения","value":"АЛСИ Фарма","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["34324371:35649313","7893318:16002631"]}}},{"name":"Изготовитель","value":"АЛСИ Фарма"},{"name":"Фасовщик","value":"АЛСИ Фарма"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Амлодипин-АЛСИ","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["17796364:17998907"]}}},{"name":"Срок годности","value":"870 дн."}]}},"fullSpecsGrouped":{"14100384276349009818":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"кровеносные сосуды, сердце"},{"name":"Назначение","value":"артериальная гипертензия, стенокардия, стенокардия Принцметала"},{"name":"Показания к применению","value":"Артериальная гипертензия (в т.ч. в составе комбинированной терапии), стабильная стенокардия, нестабильная стенокардия (в т.ч. стенокардия Принцметала)."},{"name":"Противопоказания","value":"- Повышенная чувствительность к амлодипину, производным дигидропиридина и другим компонентам препарата;\u003Cbr /\u003E- тяжелая артериальная гипотензия (систолическое АД менее 90 мм рт.ст.);\u003Cbr /\u003E- обструкция выносящего тракта левого желудочка (включая тяжелый аортальный стеноз);\u003Cbr /\u003E- шок (включая кардиогенный);\u003Cbr /\u003E- гемодинамически нестабильная сердечная недостаточность после инфаркта миокарда;\u003Cbr /\u003E- возраст до 18 лет (эффективность и безопасность не установлены);\u003Cbr /\u003E- дефицит лактазы, непереносимость лактозы, глюкозо-галактозная мальабсорбция.\u003Cbr /\u003E"},{"name":"Состав","value":"Одна таблетка содержит:\u003Cbr /\u003Eдействующее вещество: амлодипина безилат - 6,9 мг или 13,8 мг, что соответствует 5 мг или 10 мг амлодипина;\u003Cbr /\u003Eвспомогательные вещества: Лудипресс (лактозы моногидрат - 85,7/171,4 мг, повидон - 3,2/6,4 мг, кросповидон - 3,2/6,4 мг) - 92,1/184,2 мг, кальция стеарат - 1,0/2,0 мг.\u003Cbr /\u003E"},{"name":"Действующее вещество","value":"Амлодипин"},{"name":"Способ применения и дозы","value":"Препарат принимают внутрь, один раз в сутки, запивая необходимым количеством воды (100 мл).\u003Cbr /\u003EПри артериальной гипертензии и стенокардии начальная доза обычно составляет 5 мг, в зависимости от индивидуальной реакции пациента ее можно увеличить до максимальной суточной дозы, составляющей 10 мг.\u003Cbr /\u003EПрименение у пожилых пациентов\u003Cbr /\u003EУ пациентов пожилого возраста препарат рекомендуется применять в средней терапевтической дозе, коррекция дозы препарата не требуется.\u003Cbr /\u003EПрименение у пациентов с нарушенной функцией печени\u003Cbr /\u003EНесмотря на то, что Т1/2 амлодипина, как и всех БМКК, увеличивается у пациентов с нарушениями функции печени, коррекции дозы препарата у данной категории пациентов обычно не требуется (см. раздел \"Особые указания\").\u003Cbr /\u003EПрименение у пациентов с нарушенной функцией почек\u003Cbr /\u003EУ пациентов с нарушениями функции почек рекомендуется применять амлодипин в обычных дозах, однако необходимо учитывать возможное незначительное увеличение Т1/2.\u003Cbr /\u003EНе требуется коррекция дозы препарата Амлодипин-АЛСИ при одновременном применении с тиазидными диуретиками, бета-адреноблокаторами и ингибиторами АПФ.\u003Cbr /\u003E"},{"name":"Побочные действия","value":"Со стороны сердечно-сосудистой системы: возможны периферические отеки, сердцебиение, гиперемия кожных покровов; при применении в высоких дозах - артериальная гипотензия, аритмии, одышка.\u003Cbr\u003EСо стороны пищеварительной системы: тошнота, боли в животе; редко - гиперплазия десен.\u003Cbr\u003EСо стороны ЦНС: возможны головная боль, усталость, сонливость, головокружение.\u003Cbr\u003EАллергические реакции: кожная сыпь, зуд."},{"name":"Фармакологическое действие","value":"Амлодипин - селективный блокатор кальциевых каналов II класса. Антигипертензивное действие обусловлено прямым расслабляющим влиянием на гладкие мышцы сосудов. Предполагается, что антиангинальное действие амлодипина связано с его способностью расширять периферические артериолы; это приводит к уменьшению ОПСС, рефлекторная тахикардия при этом не возникает. В результате происходит снижение потребности миокарда в кислороде и потребления энергии сердечной мышцей. С другой стороны, амлодипин, по-видимому, вызывает расширение коронарных артерий крупного калибра и коронарных артериол как интактных, так и ишемизированных участков миокарда. Это обеспечивает поступление кислорода к миокарду при спазмах коронарных артерий."},{"name":"Фармакологическая группа","value":"блокатор \"медленных\" кальциевых каналов"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Хранить при температуре не выше 25 °С."},{"name":"Передозировка","value":"Симптомы: выраженное снижение АД с возможным развитием рефлекторной тахикардии и чрезмерной периферической вазодилатации (существует вероятность появления выраженной и стойкой артериальной гипотензии, в том числе с развитием шока и летального исхода).\u003Cbr /\u003EЛечение: промывание желудка, назначение активированного угля (особенно в первые 2 ч после передозировки), горизонтальное положение с низким изголовьем, активное поддержание функции сердечно-сосудистой системы, мониторинг показателей работы сердца и легких, контроль объема циркулирующей крови и диуреза. Для восстановления тонуса сосудов - применение сосудосуживающих средств (при отсутствии противопоказаний к их применению); для устранения последствий блокады кальциевых каналов - внутривенное введение глюконата кальция. Гемодиализ неэффективен.\u003Cbr /\u003E"},{"name":"Применение при беременности и кормлении грудью","value":"Безопасность применения препарата Амлодипин-АЛСИ во время беременности не установлена, поэтому применение во время беременности возможно только в случае, когда польза для матери превышает риск для плода и новорожденного.\u003Cbr\u003EДанные, свидетельствующие о выделении амлодипина в грудное молоко, отсутствуют. Однако известно, что другие БМКК (производные дигидропиридина) выделяются в грудное молоко. В связи с этим при необходимости применения препарата Амлодипин-АЛСИ в период лактации следует решить вопрос о прекращении грудного вскармливания.\u003Cbr\u003EНе было выявлено влияния амлодипина на фертильность в ходе большинства исследований на крысах. В одном из исследований на самцах крыс сообщалось о побочном влиянии на фертильность."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Хотя на фоне применения препарата Амлодипин-АЛСИ какого-либо отрицательного влияния на способность управлять автотранспортом или другими сложными механизмами не наблюдалось, однако, вследствие возможного чрезмерного снижения АД, развития головокружения, сонливости и других побочных реакций, следует соблюдать осторожность в перечисленных ситуациях, особенно в начале лечения и при изменении режима дозирования (увеличения дозы)."},{"name":"Особые указания","value":"С осторожностью применяют при нарушениях функции печени, при стенозе устья аорты, при хронической сердечной недостаточности. Пациентам с нарушениями функции почек, а также пациентам пожилого возраста снижения дозы не требуется. Возможно применение амлодипина для лечения пациентов с дилатационной (неишемической) кардиомиопатией, сопровождающейся тяжелой формой хронической сердечной недостаточности."},{"name":"Взаимодействие","value":"Амлодипин может безопасно применяться для лечения артериальной гипертензии вместе с тиазидными диуретиками, альфа-адреноблокаторами, бета-адреноблокаторами или ингибиторами АПФ. У пациентов со стабильной стенокардией амлодипин можно комбинировать с другими антиангинальными средствами, например, с нитратами пролонгированного или короткого действия, бета-адреноблокаторами.\u003Cbr /\u003EВ отличие от других БМКК клинически значимого взаимодействия амлодипина (III поколение БМКК) не было обнаружено при совместном применении с нестероидными противовоспалительными препаратами (НПВП), в том числе и с индометацином.\u003Cbr /\u003EВозможно усиление антиангинального и гипотензивного действия БМКК при совместном применении с тиазидными и \"петлевыми\" диуретиками, ингибиторами АПФ, бета-адреноблокаторами и нитратами, а также усиление их гипотензивного действия при совместном применении с альфа1-адреноблокаторами, нейролептиками.\u003Cbr /\u003EХотя при изучении амлодипина отрицательного инотропного действия обычно не наблюдали, тем не менее, некоторые БМКК могут усиливать выраженность отрицательного инотропного действия антиаритмических средств, вызывающих удлинение интервала QT (например, амиодарон и хинидин).\u003Cbr /\u003EАмлодипин может также безопасно применяться одновременно с антибиотиками и гипогликемическими средствами для приема внутрь.\u003Cbr /\u003EОднократный прием силденафила в дозе 100 мг у пациентов с эссенциальной гипертензией не оказывает влияния на параметры фармакокинетики амлодипина. Повторное применение амлодипина в дозе 10 мг и аторвастатина в дозе 80 мг не сопровождается значительными изменениями показателей фармакокинетики аторвастатина.\u003Cbr /\u003EОдновременное многократное применение амлодипина в дозе 10 мг и симвастатина в дозе 80 мг приводит к повышению экспозиции симвастатина на 77%. В таких случаях следует ограничить дозу симвастатина до 20 мг.\u003Cbr /\u003EАмлодипин при однократном и повторном применении в дозе 10 мг не влияет на фармакокинетику этанола.\u003Cbr /\u003EПротивовирусные препараты (например, ритонавир) увеличивают плазменные концентрации БМКК, в том числе и амлодипина.\u003Cbr /\u003EНейролептики и изофлуран усиливают гипотензивное действие производных дигидропиридина.\u003Cbr /\u003EПрепараты кальция могут уменьшить эффект БМКК.\u003Cbr /\u003EПри совместном применении БМКК с препаратами лития (для амлодипина данные отсутствуют), возможно усиление проявлений нейротоксичности последних (тошнота, рвота, диарея, атаксия, тремор, шум в ушах).\u003Cbr /\u003EИсследования одновременного применения амлодипина и циклоспорина у здоровых добровольцев и всех групп пациентов, за исключением пациентов после трансплантации почки, не проводились. Различные исследования взаимодействия амлодипина с циклоспорином у пациентов после трансплантации почки показывают, что применение данной комбинации может не приводить к какому-либо эффекту, либо повышать минимальную концентрацию циклоспорина в различной степени до 40%. Следует принимать во внимание эти данные и контролировать концентрацию циклоспорина у этой группы пациентов при одновременном применении циклоспорина и амлодипина.\u003Cbr /\u003EАмлодипин не оказывает влияния на концентрацию в сыворотке крови дигоксина и его почечный клиренс.\u003Cbr /\u003EАмлодипин не оказывает существенного влияния на действие варфарина (протромбиновое время).\u003Cbr /\u003EЦиметидин не влияет на фармакокинетику амлодипина.\u003Cbr /\u003EВ исследованиях in vitro амлодипин не влияет на связывание с белками плазмы крови дигоксина, фенитоина, варфарина и индометацина.\u003Cbr /\u003EОдновременный однократный прием 240 мл грейпфрутового сока и 10 мг амлодипина внутрь не сопровождается существенным изменением фархмакокинетики амлодипина. Тем не менее, не рекомендуется применять грейпфрутовый сок и амлодипин одновременно, так как при генетическом полиморфизме изофермента CYP3A4 возможно повышение биодоступности амлодипина и, вследствие этого, усиление гипотензивного эффекта.\u003Cbr /\u003EОднократный прием алюминий/магнийсодержащих антацидов не оказывает существенного влияния на фармакокинетику амлодипина.\u003Cbr /\u003EПри одновременном применении дилтиазема (ингибитор изофермента CYP3A4) в дозе 180 мг и амлодипина в дозе 5 мг у пациентов пожилого возраста (от 69 до 87 лет) с артериальной гипертензией отмечается повышение системной экспозиции амлодипина на 57%.\u003Cbr /\u003EОдновременное применение амлодипина и эритромицина у здоровых добровольцев (от 18 до 43 лет) не приводит к значительным изменениям экспозиции амлодипина (увеличение площади под кривой \"концентрация-время\" AUC на 22%). Несмотря на то, что клиническое значение этих эффектов до конца не ясно, они могут быть более ярко выражены у пожилых пациентов.\u003Cbr /\u003EМощные ингибиторы изофермента CYP3A4 (например, кетоконазол, итраконазол) могут приводить к увеличению концентрации амлодипина в плазме крови в большей степени, чем дилтиазем. Следует с осторожностью применять амлодипин и ингибиторы изофермента CYP3A4.\u003Cbr /\u003EУ пациентов, принимающих одновременно кларитромицин (ингибитор изофермента CYP3A4) и амлодипин, повышен риск снижения артериального давления. Пациентам, принимающим такую комбинацию, рекомендуется находиться под тщательным медицинским наблюдением.\u003Cbr /\u003EДанных о влиянии индукторов изофермента CYP3A4 на фармакокинетику амлодипина нет. Следует тщательно контролировать АД при одновременном применении амлодипина и индукторов изофермента CYP3A4.\u003Cbr /\u003EПри одновременном применении такролимуса с амлодипином есть риск увеличения концентрации такролимуса в плазме крови. Для того, чтобы избежать токсичности такролимуса при одновременном применении с амлодипином, следует контролировать концентрацию такролимуса в плазме крови пациентов и корректировать дозу такролимуса в случае необходимости.\u003Cbr /\u003E"},{"name":"Регистрационный номер","value":"ЛСР-009349/09"},{"name":"Дата государственной регистрации","value":"08.02.2019"},{"name":"Владелец регистрационного удостоверения","value":"АЛСИ Фарма"},{"name":"Изготовитель","value":"АЛСИ Фарма"},{"name":"Фасовщик","value":"АЛСИ Фарма"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Амлодипин-АЛСИ"},{"name":"Срок годности","value":"870 дн."}]}],"transitionId":"tr_16501434837819786614"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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72 ₽

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ЕАПТЕКА
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    на основе 34 оценки
    Цена 135 ₽
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  • Амлодипин таб., 5 мг, 30 шт.
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    Амлодипин таб., 5 мг, 30 шт.

    Рейтинг товара: 4.7 из 5
    на основе 69 оценок
    Цена 51 ₽
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  • Амлодипин Реневал таб., 5 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-0gddu7i3udx/toggleWishlist":{"skuId":"101465762432","productId":1451489305,"offerId":"E2yTJId5EreSACR60yB7SA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ3bHglZ/PkId3EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcImfCPtAUQgNXS/vkCGPKsgggg19zBBw==","sign":"NUZtTgTOWD30fkhCqla1Lw2dxI40qCz8gv0OBuv3geI="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-0gddu7i3udx/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Амлодипин Реневал таб., 5 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 19 оценок
    Цена 58 ₽
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  • Амлодипин-Прана таб., 5 мг, 30 шт.
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    Амлодипин-Прана таб., 5 мг, 30 шт.

    Рейтинг товара: 4.7 из 5
    на основе 36 оценок
    Цена 58 ₽
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  • Амлодипин таб., 10 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-mb4u1q20ci/toggleWishlist":{"skuId":"228018661","productId":1401075587,"offerId":"_JQoerrb1X9HBFPvABvM9Q","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ3bHglZ/PkId3EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIg++KnAUQ5ZPdbBjX8c8GINfcwQc=","sign":"vxukbo+pt88e0rCXu6RjszSv4VqO80jE2B839yoYtGI="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-mb4u1q20ci/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Амлодипин таб., 10 мг, 30 шт.

    Рейтинг товара: 4.9 из 5
    на основе 43 оценки
    Цена 90 ₽
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  • Амлодипин-боримед таб., 10 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-hy7d6zgheyf/toggleWishlist":{"skuId":"227933881","productId":1401075685,"offerId":"C6JCg7NgUoV2lTqp_SP8Eg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ3bHglZ/PkId3EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI5e+KnAUQuf3XbBj7lpAHINfcwQc=","sign":"S7mVmLeWiMM3blRlWmu6EG/F2gt0E6fOwnHMDtQ2BBw="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-hy7d6zgheyf/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Амлодипин-боримед таб., 10 мг, 30 шт.

    Рейтинг товара: 4.8 из 5
    на основе 17 оценок
    Цена 61 ₽
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  • Веро-Амлодипин таб., 5 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ikfdc5j1hul/toggleWishlist":{"skuId":"228001770","productId":1401075600,"offerId":"SlNOlWijnVomPSs5iUTQbw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ3bHglZ/PkId3EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIkO+KnAUQ6o/cbBja1KEFINfcwQc=","sign":"6X3hg7QGW7VvjdsI7xFkpSmjx02FWR2RmXvSCAQwAHw="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ikfdc5j1hul/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Веро-Амлодипин таб., 5 мг, 30 шт.

    Рейтинг товара: 4.9 из 5
    на основе 10 оценок
    Цена 56 ₽
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  • Амлодипин-Тева таб., 5 мг, 30 шт.
    –21 %
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    Амлодипин-Тева таб., 5 мг, 30 шт.

    Рейтинг товара: 4.8 из 5
    на основе 5 оценок
    Цена 191 ₽ вместо 241
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  • Амлодипин (Амлодивел) таб., 5 мг, 60 шт.
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    Амлодипин (Амлодивел) таб., 5 мг, 60 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 129 ₽
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  • Лизиноприл-Алси таб., 10 мг, 20 шт.
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    Лизиноприл-Алси таб., 10 мг, 20 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 70 ₽
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  • Амлодипин таб., 5 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-izhxx1gtkkl/toggleWishlist":{"skuId":"934304008","productId":1401076006,"offerId":"1PIkKKXuuW7-x67KHFbdjQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ3bHglZ/PkId3EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIpvKKnAUQiLLBvQMYo6LZByDX3MEH","sign":"dj8NoidLSy8ICqNCQD/tblYIz3SHbJu0Ur+IwxaAAxo="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-izhxx1gtkkl/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Амлодипин таб., 5 мг, 30 шт.

    Рейтинг товара: 4.8 из 5
    на основе 25 оценок
    Цена 41 ₽
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Инструкция

Показания к применению

Артериальная гипертензия (в т.ч. в составе комбинированной терапии), стабильная стенокардия, нестабильная стенокардия (в т.ч. стенокардия Принцметала).

Противопоказания

- Повышенная чувствительность к амлодипину, производным дигидропиридина и другим компонентам препарата;
- тяжелая артериальная гипотензия (систолическое АД менее 90 мм рт.ст.);
- обструкция выносящего тракта левого желудочка (включая тяжелый аортальный стеноз);
- шок (включая кардиогенный);
- гемодинамически нестабильная сердечная недостаточность после инфаркта миокарда;
- возраст до 18 лет (эффективность и безопасность не установлены);
- дефицит лактазы, непереносимость лактозы, глюкозо-галактозная мальабсорбция.

Способ применения и дозы

Препарат принимают внутрь, один раз в сутки, запивая необходимым количеством воды (100 мл).
При артериальной гипертензии и стенокардии начальная доза обычно составляет 5 мг, в зависимости от индивидуальной реакции пациента ее можно увеличить до максимальной суточной дозы, составляющей 10 мг.
Применение у пожилых пациентов
У пациентов пожилого возраста препарат рекомендуется применять в средней терапевтической дозе, коррекция дозы препарата не требуется.
Применение у пациентов с нарушенной функцией печени
Несмотря на то, что Т1/2 амлодипина, как и всех БМКК, увеличивается у пациентов с нарушениями функции печени, коррекции дозы препарата у данной категории пациентов обычно не требуется (см. раздел "Особые указания").
Применение у пациентов с нарушенной функцией почек
У пациентов с нарушениями функции почек рекомендуется применять амлодипин в обычных дозах, однако необходимо учитывать возможное незначительное увеличение Т1/2.
Не требуется коррекция дозы препарата Амлодипин-АЛСИ при одновременном применении с тиазидными диуретиками, бета-адреноблокаторами и ингибиторами АПФ.
Полная инструкция
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Амлодипин-АЛСИ таб.
Амлодипин-АЛСИ таб., 10 мг, 30 шт.
5.0
(1)
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Инструкция

72 ₽

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5.0
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