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Описание

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Анастрозол таб. п/о плен., 1 мг, 30 шт.

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4.9
(11)
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Коротко о товаре

Артикул Маркета
3176492226
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
{"widgets":{"@card/SpecsList":{"/content/page/fancyPage/productSpecsList":{"wrapperProps":{"margins":{"top":4,"bottom":4}},"specsLimit":5,"title":"Коротко о товаре","titleSize":"14","type":"minimal","offset":"s","isHealthCategory":true,"forceShowWidget":true,"withFridge":true}}},"meta":{"/content/page/fancyPage/productSpecsList":{"name":"@card/SpecsList"}},"collections":{"minimalSpecs":{"13821556505820754347":{"specItems":[{"name":"Артикул Маркета","value":"3176492226","withCopyValueButton":true},{"name":"тип препарата","value":"рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"назначение","value":"противоопухолевая терапия, рак молочной железы","transition":{"type":"list","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["36476390:36618438,36617629"]}}},{"name":"действующее вещество","value":"Анастрозол","transition":{"type":"list","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["27144131:28708571"]}}},{"name":"возраст","value":"от 18 лет"},{"name":"форма выпуска","value":"таблетки"},{"name":"страна-производитель","value":"Россия"}]}},"compactSpecs":{"13821556505820754347":{"specItems":[{"name":"Артикул Маркета","value":"3176492226","withCopyValueButton":true},{"name":"Тип препарата","value":"Рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"Действующее вещество","value":"Анастрозол","transition":{"type":"list","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["27144131:28708571"]}}},{"name":"Возраст","value":"От 18 лет"},{"name":"Форма выпуска","value":"Таблетки"}]}},"fullSpecs":{"13821556505820754347":{"specItems":[{"name":"Тип препарата","value":"лекарственный препарат","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["34324371:35649313"]}}},{"name":"Рецептурный препарат","value":"да","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["27272850:1,0"]}}},{"name":"Органы и системы","value":"молочные железы","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["34045610:34516005"]}}},{"name":"Назначение","value":"противоопухолевая терапия, рак молочной железы","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["36476390:36618438,36617629"]}}},{"name":"Показания к применению","value":"Адъювантная терапия раннего гормоноположительного рака молочной железы у женщин в постменопаузе;\u003Cbr\u003E\nЛечение распространенного рака молочной железы у женщин в постменопаузе;\u003Cbr\u003E\nАдъювантная терапия раннего гормоноположительного рака молочной железы у женщин в постменопаузе после терапии тамоксифеном в течение 2-3 лет."},{"name":"Противопоказания","value":"Повышенная чувствительность к анастрозолу или другим компонентам препарата;\u003Cbr\u003E\nБеременность и период кормления грудью;\u003Cbr\u003E\nПременопаузальный период;\u003Cbr\u003E\nТяжелая степень почечной недостаточности (клиренс креатинина \u003C 20 мл/мин);\u003Cbr\u003E\nСредняя степень печеночной недостаточности;\u003Cbr\u003E\nТяжелая степень печеночной недостаточности (безопасность и эффективность не установлены);\u003Cbr\u003E\nСопутствующая терапия тамоксифеном или препаратами, содержащими эстрогены;\u003Cbr\u003E\nДетский возраст до 18 лет (безопасность и эффективность у детей не установлены).\u003Cbr\u003E"},{"name":"Состав","value":"1 таблетка, покрытая пленочной оболочкой, содержит: Активное вещество: анастрозол - 1,0 мг; Вспомогательные вещества (ядро): лактозы моногидрат (сахар молочный) - 72,0 мг, целлюлоза микрокристаллическая - 15,6 мг, повидон (поливинилпирролидон) - 3,0 мг, магния стеарат - 0,9 мг, кремния диоксид коллоидный - 0,5 мг, карбоксиметилкрахмал натрия - 2,0 мг.\u003Cbr\u003E\nВспомогательные вещества (оболочка): гипромеллоза - 1,65 мг, макрогол-4000 - 0,45 мг, титана диоксид - 0,90 мг."},{"name":"Действующее вещество","value":"Анастрозол","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["27144131:28708571"]}}},{"name":"Способ применения и дозы","value":"Внутрь. Таблетку проглатывают целиком, запивая водой. Рекомендуется принимать препарат в одно и то же время вне зависимости от приема пищи\u003Cbr\u003E.\nВзрослые, включая пожилых: по 1 мг внутрь 1 раз в сутки длительно. При появлении признаков прогрессирования заболевания прием препарата следует прекратить. В качестве адъювантной терапии рекомендуемая продолжительность лечения - 5 лет.\u003Cbr\u003E\nЛегкая и средняя степень почечной недостаточности: коррекции дозы у пациентов с легкими и умеренными нарушениями функции почек не требуется.\u003Cbr\u003E\nЛегкая степень печеночной недостаточности: коррекции дозы у пациентов с легкой степенью печеночной недостаточности не требуется."},{"name":"Побочные действия","value":"Нарушения со стороны сосудов: \"приливы\" крови к лицу, повышение артериального давления.\u003Cbr\u003E\nНарушения со стороны скелетно-мышечной и соединительной тканей: артралгия/скованность суставов, артрит; боль в костях и мышцах, триггерный палец.\u003Cbr\u003E\nНарушения со стороны мочеполовой системы: инфекции мочевыводящих путей, вульвовагинит, сухость слизистой оболочки влагалища, влагалищные кровотечения (в основном в течение первых недель после отмены или смены предшествующей гормональной терапии на анастрозол).\u003Cbr\u003E\nНарушения со стороны кожи и подкожных тканей: кожная сыпь, истончение волос, потоотделение, алопеция; аллергические реакции: крапивница, мультиформная эритема, анафилактоидная реакция, кожный васкулит (включая отдельные случаи пурпуры (синдром Шенлейна-Геноха), синдром Стивенса-Джонсона, ангионевротический отек.\u003Cbr\u003E\nНарушения со стороны желудочно-кишечного тракта: тошнота, диарея, рвота, запор, диспепсия, желудочно-кишечные расстройства.\u003Cbr\u003E\nНарушения со стороны крови и лимфатической системы: анемия, лимфедема, венозная тромбоэмболия.\u003Cbr\u003E\nНарушения со стороны дыхательной системы, органов грудной клетки и средостения: фарингит, одышка, синусит, бронхит.\u003Cbr\u003E\nНарушения со стороны органа зрения: катаракта.\u003Cbr\u003E\nСо стороны гепатобилиарной системы: повышение активности щелочной фосфатазы, аланинаминотрансферазы, аспартатаминотрансферазы, повышение активности гамма-глутамилтрансферазы и концентрации билирубина, гепатит.\u003Cbr\u003E\nНарушения со стороны нервной системы: головная боль, сонливость, депрессия, бессонница, головокружение, беспокойство, парестезия, синдром \"запястного канала\" (в основном наблюдался у пациенток с факторами риска данного заболевания).\u003Cbr\u003E\nНарушения со стороны обмена веществ и питания: анорексия, гиперхолестеринемия, повышение массы тела, гиперкальциемия (с/без повышения концентрации паратгормона). Прием препарата может вызывать снижение минеральной плотности костной ткани в связи со снижением концентрации циркулирующего эстрадиола, тем самым, повышая риск возникновения остеопороза и переломов костей.\u003Cbr\u003E\nПрочие: астения, боль в спине, боль в животе, боль в груди, возникновение вторичных инфекций, гриппоподобный синдром, новообразования."},{"name":"Фармакологическое действие","value":"Анастрозол является высокоселективным нестероидным ингибитором ароматазы - фермента, с помощью которого у женщин в постменопаузе андростендион в периферических тканях превращается в эстрон и далее в эстрадиол. Снижение циркулирующих концентраций эстрадиола, как выяснилось, оказывает положительное действие на женщин с раком молочной железы. У женщин в постменопаузе анастрозол в суточной дозе 1 мг вызывает снижение концентрации эстрадиола на 80 %.\u003Cbr\u003E\nАнастрозол не обладает прогестогенной, андрогенной или эстрогенной активностью. Регулярный прием суточных доз анастрозола вплоть до 10 мг не оказывает влияния на секрецию кортизола или альдостерона, следовательно, при его назначении не требуется заместительного введения кортикостероидов."},{"name":"Фармакологическая группа","value":"противоопухолевые средства","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["34045110:34518988"]}}},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["35947170:36763744"]}}},{"name":"Пол","value":"для женщин"},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"В защищенном от света месте при температуре не выше 25 °С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Описаны единичные клинические случаи случайной передозировки препарата. Разовая доза анастрозола, которая могла бы привести к симптомам, угрожающим жизни, не установлена. Специфического антидота не существует, в случае передозировки лечение должно быть симптоматическим.\u003Cbr\u003E\nЛечение: можно индуцировать рвоту, если больной находится в сознании. Может быть проведен диализ. Рекомендуется общая поддерживающая терапия, наблюдение за больным и контроль функции жизненно важных органов и систем."},{"name":"Применение при беременности и кормлении грудью","value":"Противопоказано при беременности. На время лечения следует прекратить грудное вскармливание."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения не следует выполнять работу, требующую высокой концентрации внимания и быстрых психомоторных реакций."},{"name":"Особые указания","value":"Безопасность и эффективность у детей не установлены. У женщин с рецептороотрицательной опухолью к эстрогенам эффективность анастрозола не была продемонстрирована, кроме тех случаев, когда имелся предшествующий положительный клинический ответ на тамоксифен. В случае сомнений в гормональном статусе пациентки менопауза должна быть подтверждена определением половых гормонов в сыворотке крови.\u003Cbr\u003E\nПрепараты, содержащие эстрогены, не должны назначаться одновременно с анастрозолом, так как эти препараты будут нивелировать его фармакологическое действие. Нет данных о применении анастрозола у пациенток со средней и тяжелой степенью печеночной недостаточности. В случае сохраняющегося маточного кровотечения на фоне приема анастрозола необходима консультация и наблюдение гинеколога.\u003Cbr\u003E\nУ пациенток с остеопорозом или с повышенным риском развития остеопороза, минеральную плотность костной ткани следует оценивать методом денситометрии, например, DEXA- сканированием (двухэнергетическая рентгеновская абсорбциометрия), в начале лечения и регулярно на его протяжении. При необходимости следует назначать лечение или профилактику остеопороза и тщательно наблюдать за состоянием пациентки. Поскольку анастрозол снижает концентрацию циркулирующего эстрадиола, это может привести к снижению минеральной плотности костной ткани. На настоящий момент отсутствуют достаточные данные относительно положительного влияния бисфосфонатов на потерю минеральной плотности костной ткани, вызванной анастрозолом или их пользы при применении с целью профилактики.\u003Cbr\u003E\nНет данных об одновременном применении анастрозола и препаратов-аналогов ЛГРГ (лютеинизирующего гормона рилизинг-гормона). Неизвестно улучшает ли анастрозол результаты лечения при совместном использовании с химиотерапией. Данные по безопасности при длительном лечении анастрозолом пока не получены. При применении анастрозола чаще, чем при терапии тамоксифеном, наблюдались ишемические заболевания, однако статистической значимости при этом не отмечено. Эффективность и безопасность анастрозола и тамоксифена при их одновременном применении вне зависимости от статуса гормональных рецепторов сравнимы с таковыми при использовании одного тамоксифена. Точный механизм данного явления пока не известен."},{"name":"Взаимодействие","value":"Исследования по лекарственному взаимодействию с феназоном (Антипирином) и циметидином указывают на то, что совместное применение анастрозола с другими препаратами вряд ли приведет к клинически значимому лекарственному взаимодействию, опосредованному цитохромом Р450. Клинически значимое лекарственное взаимодействие при приёме препарата Анастрозол одновременно с другими часто назначаемыми препаратами отсутствует. На данный момент нет сведений о применении препарата Анастрозола в комбинации с другими противоопухолевыми препаратами.\u003Cbr\u003E\nПрепараты, содержащие эстрогены, уменьшают фармакологическое действие анастрозола, в связи с чем, они не должны назначаться с ним одновременно. Не следует назначать тамоксифен одновременно с анастрозолом, поскольку он может ослабить фармакологическое действие последнего."},{"name":"Источник","value":"\u003Ca href=\"https://www.vidal.ru\" target=\"_blank\"\u003EСправочник лекарственных препаратов Видаль<\u002Fa\u003E"},{"name":"Дата государственной регистрации","value":"12.08.2019"},{"name":"Владелец регистрационного удостоверения","value":"ОЗОН Фармацевтика","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["34324371:35649313","7893318:13891799"]}}},{"name":"Изготовитель","value":"ОЗОН"},{"name":"Фасовщик","value":"ОЗОН"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Анастрозол","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["17796364:18050516"]}}},{"name":"Срок годности","value":"35 мес."}]}},"fullSpecsGrouped":{"13821556505820754347":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"молочные железы"},{"name":"Назначение","value":"противоопухолевая терапия, рак молочной железы"},{"name":"Показания к применению","value":"Адъювантная терапия раннего гормоноположительного рака молочной железы у женщин в постменопаузе;\u003Cbr\u003E\nЛечение распространенного рака молочной железы у женщин в постменопаузе;\u003Cbr\u003E\nАдъювантная терапия раннего гормоноположительного рака молочной железы у женщин в постменопаузе после терапии тамоксифеном в течение 2-3 лет."},{"name":"Противопоказания","value":"Повышенная чувствительность к анастрозолу или другим компонентам препарата;\u003Cbr\u003E\nБеременность и период кормления грудью;\u003Cbr\u003E\nПременопаузальный период;\u003Cbr\u003E\nТяжелая степень почечной недостаточности (клиренс креатинина \u003C 20 мл/мин);\u003Cbr\u003E\nСредняя степень печеночной недостаточности;\u003Cbr\u003E\nТяжелая степень печеночной недостаточности (безопасность и эффективность не установлены);\u003Cbr\u003E\nСопутствующая терапия тамоксифеном или препаратами, содержащими эстрогены;\u003Cbr\u003E\nДетский возраст до 18 лет (безопасность и эффективность у детей не установлены).\u003Cbr\u003E"},{"name":"Состав","value":"1 таблетка, покрытая пленочной оболочкой, содержит: Активное вещество: анастрозол - 1,0 мг; Вспомогательные вещества (ядро): лактозы моногидрат (сахар молочный) - 72,0 мг, целлюлоза микрокристаллическая - 15,6 мг, повидон (поливинилпирролидон) - 3,0 мг, магния стеарат - 0,9 мг, кремния диоксид коллоидный - 0,5 мг, карбоксиметилкрахмал натрия - 2,0 мг.\u003Cbr\u003E\nВспомогательные вещества (оболочка): гипромеллоза - 1,65 мг, макрогол-4000 - 0,45 мг, титана диоксид - 0,90 мг."},{"name":"Действующее вещество","value":"Анастрозол"},{"name":"Способ применения и дозы","value":"Внутрь. Таблетку проглатывают целиком, запивая водой. Рекомендуется принимать препарат в одно и то же время вне зависимости от приема пищи\u003Cbr\u003E.\nВзрослые, включая пожилых: по 1 мг внутрь 1 раз в сутки длительно. При появлении признаков прогрессирования заболевания прием препарата следует прекратить. В качестве адъювантной терапии рекомендуемая продолжительность лечения - 5 лет.\u003Cbr\u003E\nЛегкая и средняя степень почечной недостаточности: коррекции дозы у пациентов с легкими и умеренными нарушениями функции почек не требуется.\u003Cbr\u003E\nЛегкая степень печеночной недостаточности: коррекции дозы у пациентов с легкой степенью печеночной недостаточности не требуется."},{"name":"Побочные действия","value":"Нарушения со стороны сосудов: \"приливы\" крови к лицу, повышение артериального давления.\u003Cbr\u003E\nНарушения со стороны скелетно-мышечной и соединительной тканей: артралгия/скованность суставов, артрит; боль в костях и мышцах, триггерный палец.\u003Cbr\u003E\nНарушения со стороны мочеполовой системы: инфекции мочевыводящих путей, вульвовагинит, сухость слизистой оболочки влагалища, влагалищные кровотечения (в основном в течение первых недель после отмены или смены предшествующей гормональной терапии на анастрозол).\u003Cbr\u003E\nНарушения со стороны кожи и подкожных тканей: кожная сыпь, истончение волос, потоотделение, алопеция; аллергические реакции: крапивница, мультиформная эритема, анафилактоидная реакция, кожный васкулит (включая отдельные случаи пурпуры (синдром Шенлейна-Геноха), синдром Стивенса-Джонсона, ангионевротический отек.\u003Cbr\u003E\nНарушения со стороны желудочно-кишечного тракта: тошнота, диарея, рвота, запор, диспепсия, желудочно-кишечные расстройства.\u003Cbr\u003E\nНарушения со стороны крови и лимфатической системы: анемия, лимфедема, венозная тромбоэмболия.\u003Cbr\u003E\nНарушения со стороны дыхательной системы, органов грудной клетки и средостения: фарингит, одышка, синусит, бронхит.\u003Cbr\u003E\nНарушения со стороны органа зрения: катаракта.\u003Cbr\u003E\nСо стороны гепатобилиарной системы: повышение активности щелочной фосфатазы, аланинаминотрансферазы, аспартатаминотрансферазы, повышение активности гамма-глутамилтрансферазы и концентрации билирубина, гепатит.\u003Cbr\u003E\nНарушения со стороны нервной системы: головная боль, сонливость, депрессия, бессонница, головокружение, беспокойство, парестезия, синдром \"запястного канала\" (в основном наблюдался у пациенток с факторами риска данного заболевания).\u003Cbr\u003E\nНарушения со стороны обмена веществ и питания: анорексия, гиперхолестеринемия, повышение массы тела, гиперкальциемия (с/без повышения концентрации паратгормона). Прием препарата может вызывать снижение минеральной плотности костной ткани в связи со снижением концентрации циркулирующего эстрадиола, тем самым, повышая риск возникновения остеопороза и переломов костей.\u003Cbr\u003E\nПрочие: астения, боль в спине, боль в животе, боль в груди, возникновение вторичных инфекций, гриппоподобный синдром, новообразования."},{"name":"Фармакологическое действие","value":"Анастрозол является высокоселективным нестероидным ингибитором ароматазы - фермента, с помощью которого у женщин в постменопаузе андростендион в периферических тканях превращается в эстрон и далее в эстрадиол. Снижение циркулирующих концентраций эстрадиола, как выяснилось, оказывает положительное действие на женщин с раком молочной железы. У женщин в постменопаузе анастрозол в суточной дозе 1 мг вызывает снижение концентрации эстрадиола на 80 %.\u003Cbr\u003E\nАнастрозол не обладает прогестогенной, андрогенной или эстрогенной активностью. Регулярный прием суточных доз анастрозола вплоть до 10 мг не оказывает влияния на секрецию кортизола или альдостерона, следовательно, при его назначении не требуется заместительного введения кортикостероидов."},{"name":"Фармакологическая группа","value":"противоопухолевые средства"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Пол","value":"для женщин"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"В защищенном от света месте при температуре не выше 25 °С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Описаны единичные клинические случаи случайной передозировки препарата. Разовая доза анастрозола, которая могла бы привести к симптомам, угрожающим жизни, не установлена. Специфического антидота не существует, в случае передозировки лечение должно быть симптоматическим.\u003Cbr\u003E\nЛечение: можно индуцировать рвоту, если больной находится в сознании. Может быть проведен диализ. Рекомендуется общая поддерживающая терапия, наблюдение за больным и контроль функции жизненно важных органов и систем."},{"name":"Применение при беременности и кормлении грудью","value":"Противопоказано при беременности. На время лечения следует прекратить грудное вскармливание."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения не следует выполнять работу, требующую высокой концентрации внимания и быстрых психомоторных реакций."},{"name":"Особые указания","value":"Безопасность и эффективность у детей не установлены. У женщин с рецептороотрицательной опухолью к эстрогенам эффективность анастрозола не была продемонстрирована, кроме тех случаев, когда имелся предшествующий положительный клинический ответ на тамоксифен. В случае сомнений в гормональном статусе пациентки менопауза должна быть подтверждена определением половых гормонов в сыворотке крови.\u003Cbr\u003E\nПрепараты, содержащие эстрогены, не должны назначаться одновременно с анастрозолом, так как эти препараты будут нивелировать его фармакологическое действие. Нет данных о применении анастрозола у пациенток со средней и тяжелой степенью печеночной недостаточности. В случае сохраняющегося маточного кровотечения на фоне приема анастрозола необходима консультация и наблюдение гинеколога.\u003Cbr\u003E\nУ пациенток с остеопорозом или с повышенным риском развития остеопороза, минеральную плотность костной ткани следует оценивать методом денситометрии, например, DEXA- сканированием (двухэнергетическая рентгеновская абсорбциометрия), в начале лечения и регулярно на его протяжении. При необходимости следует назначать лечение или профилактику остеопороза и тщательно наблюдать за состоянием пациентки. Поскольку анастрозол снижает концентрацию циркулирующего эстрадиола, это может привести к снижению минеральной плотности костной ткани. На настоящий момент отсутствуют достаточные данные относительно положительного влияния бисфосфонатов на потерю минеральной плотности костной ткани, вызванной анастрозолом или их пользы при применении с целью профилактики.\u003Cbr\u003E\nНет данных об одновременном применении анастрозола и препаратов-аналогов ЛГРГ (лютеинизирующего гормона рилизинг-гормона). Неизвестно улучшает ли анастрозол результаты лечения при совместном использовании с химиотерапией. Данные по безопасности при длительном лечении анастрозолом пока не получены. При применении анастрозола чаще, чем при терапии тамоксифеном, наблюдались ишемические заболевания, однако статистической значимости при этом не отмечено. Эффективность и безопасность анастрозола и тамоксифена при их одновременном применении вне зависимости от статуса гормональных рецепторов сравнимы с таковыми при использовании одного тамоксифена. Точный механизм данного явления пока не известен."},{"name":"Взаимодействие","value":"Исследования по лекарственному взаимодействию с феназоном (Антипирином) и циметидином указывают на то, что совместное применение анастрозола с другими препаратами вряд ли приведет к клинически значимому лекарственному взаимодействию, опосредованному цитохромом Р450. Клинически значимое лекарственное взаимодействие при приёме препарата Анастрозол одновременно с другими часто назначаемыми препаратами отсутствует. На данный момент нет сведений о применении препарата Анастрозола в комбинации с другими противоопухолевыми препаратами.\u003Cbr\u003E\nПрепараты, содержащие эстрогены, уменьшают фармакологическое действие анастрозола, в связи с чем, они не должны назначаться с ним одновременно. Не следует назначать тамоксифен одновременно с анастрозолом, поскольку он может ослабить фармакологическое действие последнего."},{"name":"Источник","value":"\u003Ca href=\"https://www.vidal.ru\" target=\"_blank\"\u003EСправочник лекарственных препаратов Видаль<\u002Fa\u003E"},{"name":"Дата государственной регистрации","value":"12.08.2019"},{"name":"Владелец регистрационного удостоверения","value":"ОЗОН Фармацевтика"},{"name":"Изготовитель","value":"ОЗОН"},{"name":"Фасовщик","value":"ОЗОН"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Анастрозол"},{"name":"Срок годности","value":"35 мес."}]}],"transitionId":"tr_3539222264054702067"}}}}
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    Цена 1 035 ₽
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  • Аримидекс таб. п/о плен., 1 мг, 28 шт.
    –9 %
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    Аримидекс таб. п/о плен., 1 мг, 28 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 1 489 ₽ вместо 1 638
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  • Тамоксифен таб., 10 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-5pvxa0py2id/toggleWishlist":{"skuId":"101335813747","productId":228088817,"offerId":"LwQorKzZd-BaNmUGBkO_eQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQucr1nbLpxP8gEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYI8bfhbBDznNfA+QIY1/HPBiDy3MEH","sign":"RiadG9d5z6ZnLJqIDEAy+l1m9otnD5HtFjPAgDJW2iI="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-5pvxa0py2id/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Тамоксифен таб., 10 мг, 30 шт.

    Рейтинг товара: 4.9 из 5
    на основе 38 оценок
    Цена 122 ₽
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  • Метотрексат таб. п/о, 2.5 мг, 50 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-16mz20hcwsj/toggleWishlist":{"skuId":"101335819761","productId":228057918,"offerId":"blNla69qfXW07H4QsxvwFA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQucr1nbLpxP8gEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIvsbfbBDxy9fA+QIY1/HPBiDy3MEH","sign":"xIOXqeoXzlVsf55cM56z3Ihk0Z6AEEBkNaHIui2kt5I="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-16mz20hcwsj/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Метотрексат таб. п/о, 2.5 мг, 50 шт.

    Рейтинг товара: 5 из 5
    на основе 4 оценки
    Цена 222 ₽
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  • Летрозол таб. п/о плен., 2.5 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ycwqlath7r/toggleWishlist":{"skuId":"101335816787","productId":186520935,"offerId":"zcvRrG2bZp86MLDiVcXSZA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQucr1nbLpxP8gEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYI56r4WBDTtNfA+QIY2uXQByDy3MEH","sign":"M9Bx7RZ8i9Gkpk3Txm3sq6LVZoP9vmSj6LNL2aIeMkI="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ycwqlath7r/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Летрозол таб. п/о плен., 2.5 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 4 оценки
    Цена 2 999 ₽
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  • Бикалутамид таб. п/о плен., 50 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-w7saif25nzn/toggleWishlist":{"skuId":"101335818756","productId":453475047,"offerId":"Yzld0--usWVUm7EcXTxauQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQucr1nbLpxP8gEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI5/Wd2AEQhMTXwPkCGISpsggg8tzBBw==","sign":"akQGn8jsnJJCOhRioG/7OcAlMuOUEQxyTCPemauSeDI="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-w7saif25nzn/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Бикалутамид таб. п/о плен., 50 мг, 30 шт.

    Рейтинг товара: 4.5 из 5
    на основе 2 оценки
    Цена 1 119 ₽
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-w7saif25nzn/addToCartButton":{"offerId":"Yzld0--usWVUm7EcXTxauQ","skuId":"101335818756","pendingCartItem":{"productId":453475047,"offerId":"Yzld0--usWVUm7EcXTxauQ","showPlaceId":"OTNDnItfwRMjN9MRHuEMMhGOFTUKjpnwHOpa6d49Oqn5MzWrjwajNsW9sb8IlqxJgaGHQHvDm_fgrPEZQXNwDAH3GyGt929kk9u2EVDWkOJxWtk2A8uaHAWAYxDyQbE2gQbmnubNZve5yktoR3nYG9fJHS7HmZGbLSqM6-bs-0jd_246OgRrggKVwx9gomeOxbYg0XrH58AcOCMkbqn-nQ,,","feeShow":"OTNDnItfwRMjN9MRHuEMMhGOFTUKjpnwHOpa6d49Oqn5MzWrjwajNsW9sb8IlqxJgaGHQHvDm_fgrPEZQXNwDAH3GyGt929kk9u2EVDWkOJxWtk2A8uaHAWAYxDyQbE2gQbmnubNZve5yktoR3nYG9fJHS7HmZGbLSqM6-bs-0jd_246OgRrggKVwx9gomeOxbYg0XrH58AcOCMkbqn-nQ,,","skuId":"101335818756","shopId":55106433,"price":{"applicablePriceDiscounts":[],"value":"1119","currency":"RUR"},"hid":"15756914","name":"Бикалутамид таб. п/о плен., 50 мг, 30 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  • Микофенолата мофетил таб. п/о плен., 500 мг, 50 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-28t0qnt19qu/toggleWishlist":{"skuId":"101812027811","productId":1763666216,"offerId":"QfWKDM9BoSReobSuy2bRQQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQucr1nbLpxP8gEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIqNL9yAYQo4Pho/sCGISpsggg8tzBBw==","sign":"Na3weD94JMDUmfJXejvdGJmmidVmRvLy+rfHqbP6IpQ="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-28t0qnt19qu/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Микофенолата мофетил таб. п/о плен., 500 мг, 50 шт.

    Рейтинг товара: 4.2 из 5
    на основе 5 оценок
    Цена 2 276 ₽
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  • Аромазин таб. п/о, 25 мг, 30 шт.
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    Аромазин таб. п/о, 25 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 2 009 ₽
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Инструкция

Показания к применению

Адъювантная терапия раннего гормоноположительного рака молочной железы у женщин в постменопаузе;
Лечение распространенного рака молочной железы у женщин в постменопаузе;
Адъювантная терапия раннего гормоноположительного рака молочной железы у женщин в постменопаузе после терапии тамоксифеном в течение 2-3 лет.

Противопоказания

Повышенная чувствительность к анастрозолу или другим компонентам препарата;
Беременность и период кормления грудью;
Пременопаузальный период;
Тяжелая степень почечной недостаточности (клиренс креатинина < 20 мл/мин);
Средняя степень печеночной недостаточности;
Тяжелая степень печеночной недостаточности (безопасность и эффективность не установлены);
Сопутствующая терапия тамоксифеном или препаратами, содержащими эстрогены;
Детский возраст до 18 лет (безопасность и эффективность у детей не установлены).

Способ применения и дозы

Внутрь. Таблетку проглатывают целиком, запивая водой. Рекомендуется принимать препарат в одно и то же время вне зависимости от приема пищи
. Взрослые, включая пожилых: по 1 мг внутрь 1 раз в сутки длительно. При появлении признаков прогрессирования заболевания прием препарата следует прекратить. В качестве адъювантной терапии рекомендуемая продолжительность лечения - 5 лет.
Легкая и средняя степень почечной недостаточности: коррекции дозы у пациентов с легкими и умеренными нарушениями функции почек не требуется.
Легкая степень печеночной недостаточности: коррекции дозы у пациентов с легкой степенью печеночной недостаточности не требуется.
Полная инструкция
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Анастрозол таб. п/о плен.
Анастрозол таб. п/о плен., 1 мг, 30 шт.
4.9
(11)
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4 вопроса
Инструкция

1 099 ₽

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4.9
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У продавца:11 оценок·2 отзыва
У всех продавцов:59 оценок·10 отзывов
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user avatar
3 недели назад • Роман Абишов • Куплен на Маркете
Достоинства: Рабочий препарат, цена которого адекватна
Недостатки: Принимать пол года, но это не недостаток, а данность
Комментарий: Советую, кому прописал врач, помогает)
user avatar
16 часов назад • Николай Гузий • Куплен на Маркете
Достоинства: шикарная тема работает как по назначению, так и off label
Недостатки: нет недостатков нет.
Посмотреть все отзывы на Маркете
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