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Альфа Д3-Тева капс., 0.25 мкг, 60 шт.

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5.0
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Дозировка: 0.25 мкг

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Количество штук в упаковке, шт.: 60

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Коротко о товаре

Артикул Маркета
3123944872
Дозировка
Количество штук в упаковке
60 шт.
Тип препарата
Рецептурный препарат
Инструкция
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Повышает абсорбцию кальция и фосфора в кишечнике, увеличивает их реабсорбцию в почках, восстанавливает положительный кальциевый баланс при лечении синдрома кальциевой мальабсорбции и снижает концентрацию в крови паратиреоидного гормона.\u003Cbr\u003EВоздействуя на обе части процесса костного ремоделирования (резорбцию и синтез), альфакальцидол не только увеличивает минерализацию костной ткани, но и повышает ее упругость за счет стимулирования синтеза белков матрикса кости, костных морфогенетических белков, факторов роста кости, что способствует уменьшению частоты развития переломов.\u003Cbr\u003EУ пациентов пожилого возраста на фоне эндокринно-иммунной дисфункции, в том числе дефицита продукции D-гормона (кальцитриола), происходит снижение общей мышечной массы (саркопения) и появление синдрома мышечной слабости (вследствие нарушения нормального функционирования нервно-мышечного аппарата), что сопровождается повышением риска падений и обусловленных этим травм и переломов. В ряде исследований было показано значительное снижение частоты падений пожилых пациентов при применении альфакальцидола. Альфакальцидол стимулирует регенерацию мышечных волокон, что восстанавливает утраченный мышечный тонус."},{"name":"Состав","value":"В 1 капсуле содержится: активное вещество: альфакальцидол 0,25 мкг;\u003Cbr\u003Eвспомогательные вещества: лимонная кислота 0,015 мг, пропилгаллат 0,020 мг, альфа-токоферол 0,020 мг, этанол 1,145 мг, масло арахиса 98,79975 мг; оболочка (.мягкая желатиновая капсула): желатин 48,55 мг, глицерол 85 % 11,70 мг, анидрисорб 85 (сорбитол 25-40 %, сорбитан 20-30 %, маннитол 0-6 %, высшие полиолы 12,5-19 %, вода 15-17 %) 7,92 мг, краситель железа оксид красный (Е172) 0,54/- мг, краситель железа оксид желтый (Е172), титана диоксид (Е171), чернила черные S-1-27794 (шеллак 59,420 %, краситель железа оксид черный (Е172) 24,650 %, бутанол 9,750 %, вода 3,250 %, пропиленгликоль (Е1520) 1,300 %, этанол денатурированный [спирт метилированный] 1,080 %, изопропанол 0.550 %) или S-1-17823 (шеллак 44,467 %, изопропанол 26,882 %, краситель железа оксид черный (Е172) 23,409 %, бутанол 2,242 %, пропиленгликоль (Е1520) 2,000 %, аммиак водный (Е527) 1,000%) следы/следы."},{"name":"Взаимодействие","value":"Индукторы микросомальных ферментов печени (в том числе фенитоин и фенобарбитал) снижают, а ингибиторы - повышают концентрацию альфакальцидола в плазме (возможно изменение его эффективности).\u003Cbr\u003EПри одновременном применении альфакальцидола с препаратами наперстянки повышается риск развития аритмии.\u003Cbr\u003EВсасывание альфакальцидола уменьшается при его совместном применении с колестирамином. колестиполом, минеральным маслом, сукральфатом, антацидами. Для снижения вероятности взаимодействия альфакальцидол следует применять за 1 час до или через 4-6 часов после приема вышеуказанных препаратов.\u003Cbr\u003EКальцитонин, производные этидроновой и памидроновой кислот, пликамицин, галлия нитрат и глюкокортикостероиды снижают эффект альфакальцидола.\u003Cbr\u003EАльфакальцидол увеличивает абсорбцию фосфорсодержащих препаратов и риск возникновения гиперфосфатемии.\u003Cbr\u003EОдновременное применение альфакальцидола с препаратами кальция, тиазидными диуретиками может вызвать гиперкальциемию за счет повышения абсорбции кальция в кишечнике, увеличения его реабсорбции в почках.\u003Cbr\u003EСочетанная терапия магнийсодержащими антацидами и витамином D может вызвать повышение содержания магния в крови, а алюминийсодержащими антацидами - алюминия в крови, особенно при ХПН.\u003Cbr\u003EОдновременное применение различных аналогов витамина D сопровождается аддитивным действием с развитием гиперкальциемии. Препарат Альфа Д3-Тева не следует назначать одновременно с другими препаратами витамина D и его производными."},{"name":"Показания к применению","value":"Заболевания, вызванные нарушением обмена кальция и фосфора вследствие недостаточного эндогенного синтеза 1,25-дигидроксивитамина D3:\u003Cbr\u003E- Остеопороз (в т.ч. постменопаузальный, сенильный, стероидный и др.);\u003Cbr\u003E- остеодистрофия при хронической почечной недостаточности (ХПН);\u003Cbr\u003E- гипопаратиреоз и псевдогипопаратиреоз;\u003Cbr\u003E- витамин D-резистентный рахит и остеомаляция."},{"name":"Противопоказания","value":"- Повышенная чувствительность к компонентам препарата, в том числе к арахису.\u003Cbr\u003E- Гиперкальциемия.\u003Cbr\u003E- Гиперфосфатемия.\u003Cbr\u003E- Гипермагниемия.\u003Cbr\u003E- Гипервитаминоз D.\u003Cbr\u003E- Период беременности и грудного вскармливания.\u003Cbr\u003E- Детский возраст до 12 лет.\u003Cbr\u003E- Длительная иммобилизация.\u003Cbr\u003E- Туберкулез легких (активная форма)."},{"name":"Способ применения и дозы","value":"Препарат принимают внутрь независимо от приема пищи, не разжевывая, запивая достаточным количеством жидкости, однократно в сутки. Длительность курса лечения определяется врачом индивидуально в каждом конкретном случае и зависит от характера заболевания и эффективности терапии.\u003Cbr\u003EВзрослые и дети с массой тела более 20 кг\u003Cbr\u003EНачальная доза - 1 мкг в сутки.\u003Cbr\u003EПоддерживающая доза - 0,25-2 мкг в сутки.\u003Cbr\u003EПри рахите и остеомаляции: от 1 до 3 мкг в сутки; при гипопаратиреозе: 1- 4 мкг в сутки; при остеодистрофии при ХПН: 0,5-2 мкг в сутки; при остеопорозе (в том числе постменопаузальном, сенильном, стероидном и др.): 0,5-1 мкг в сутки.\u003Cbr\u003EНачинать лечение рекомендуется с минимальных доз, контролируя 1 раз в неделю концентрацию кальция и фосфора в плазме крови. Дозу препарата можно повышать на 0,25 или 0,5 мкг/сут до стабилизации биохимических показателей. При достижении минимальной эффективной дозы рекомендуется контролировать концентрацию кальция в плазме крови каждые 3-5 недель."},{"name":"Применение при беременности","value":"Гиперкальциемия у матери в период беременности, связанная с длительной передозировкой витамина D, может вызвать у плода повышение чувствительности к витамину D, подавление функции паращитовидной железы, синдром специфической эльфоподобной внешности, задержку умственного развития, аортальный стеноз.\u003Cbr\u003EПрепарат противопоказан к применению при беременности и в период грудного вскармливания."},{"name":"Побочные действия","value":"Наиболее распространенными нежелательными эффектами препарата Альфа ДЗ-Тева* являются: гиперкальциемия, гиперкальциурия и витамин D-зависимая токсичность.\u003Cbr\u003EНиже приводятся данные о неблагоприятных побочных реакциях, в зависимости от частоты их возникновения. Неблагоприятные побочные реакции, отличные от признаков гиперкальциемии, полученные как отдельные сообщения, также включены.\u003Cbr\u003EЧастота определяется как: очень часто - ≥1/10; часто - ≥1/100 и \u003C1/10; нечасто - ≥1/1000 и \u003C1/100; редко - ≥1/10000 и \u003C1/1000; очень редко - \u003C1/10000 (включая отдельные сообщения); частота неизвестна (невозможно оценить на основании имеющихся данных).\u003Cbr\u003EСо стороны обмена веществ\u003Cbr\u003EОчень часто: гиперкальциемия; нечасто: метастатические кальцификации, гиперфосфатемия, высокое содержание кальциево-фосфатных соединений, анорексия; частота неизвестна: гипермагниемия, сниженный аппетит, снижение массы тела, дегидратация, прекращение роста, альбуминурия, гиперхолестеринемия, повышение уровня ACT и АЛТ в сыворотке крови.\u003Cbr\u003EАллергические реакции\u003Cbr\u003EЧастота неизвестна: реакции гиперчувствительности с такими симптомами, как: лихорадка, озноб, крапивница и отек языка.\u003Cbr\u003EСо стороны нервной системы\u003Cbr\u003EНечасто: головная боль, дизестезия, дисгевзия; очень редко: нарушения психики, галлюцинации, кома, апатия; частота неизвестна: гипертермия.\u003Cbr\u003EСо стороны сердечно-сосудистой системы Редко: тахикардия, повышение артериального давления.\u003Cbr\u003EСо стороны пищеварительной системы Нечасто: тошнота, рвота, боль в животе, запор, диарея, диспепсия; очень редко: острый панкреатит; частота неизвестна: изъязвление языка, изъязвление десен, полидипсия.\u003Cbr\u003EСо стороны кожных покровов Часто: кожный зуд; очень редко: мультиформная эритема, псориаз; частота неизвестна: сыпь (эритематозная, макулопапулезная, пустулезная), эксфолиативный дерматит.\u003Cbr\u003EСо стороны органов чувств Очень редко: кальциноз конъюнктивы и склеры.\u003Cbr\u003EСо стороны дыхательной системы Частота неизвестна: ринит.\u003Cbr\u003EСо стороны мочевыделительной системы Часто: гиперкальциурия, повышение уровня креатинина и мочевины в сыворотке крови; \u003Cbr\u003Eчастота неизвестна: почечная недостаточность, нефрокальциноз, инфекции мочевыводящих путей.Со стороны репродуктивной системы Частота неизвестна: снижение либидо.\u003Cbr\u003EПрочие Редко: кальциноз, астения и повышенная утомляемость."},{"name":"Передозировка","value":"Ранние симптомы гипервитаминоза витамина D (обусловленные гиперкальциемией): запор или диарея, сухость слизистой оболочки полости рта, головная боль, жажда, поллакиурия, никтурия, полиурия, анорексия, металлический привкус во рту, тошнота, рвота, общая слабость, гиперкальциурия.\u003Cbr\u003EПоздние симптомы гипервитаминоза витамина D: боль в костях, помутнение мочи (появление в моче гиалиновых цилиндров), повышение артериального давления, кожный зуд, светобоязнь, гиперемия конъюнктивы, аритмия, сонливость, миалгия, тошнота, рвота, снижение массы тела, редко - изменения психики и настроения, спутанность сознания.\u003Cbr\u003EСимптомы хронической интоксикации витамина D: кальциноз мягких тканей, кровеносных сосудов и внутренних органов (почек, легких), почечная и сердечнососудистая недостаточность, нарушение роста у детей.\u003Cbr\u003EУровень кальция в сыворотке крови нормализуется через 2-7 дней после прекращения приема препарата.\u003Cbr\u003EГиперкальциемия лечится временным прекращением приема альфакальцидола. введением диеты с низким содержанием кальция и прекращением приема добавок кальция.\u003Cbr\u003EВ тяжелых случаях острой случайной передозировки и устойчивой гиперкальциемии следует предпринять общие поддерживающие мероприятия.\u003Cbr\u003EВ случае передозировки следует отменить препарат. В ранние сроки острой передозировки показано промывание желудка и/или прием внутрь минерального масла (вазелинового), способствующего уменьшению всасывания и увеличению выведения препарата через кишечник. В тяжелых случаях (уровень кальция в сыворотке крови \u003E3ммоль/л) может потребоваться проведение поддерживающих лечебных мероприятий - гидратации с введением инфузионных солевых растворов (с целью форсированного диуреза), в некоторых случаях - назначение глюкокортикостероидных препаратов, петлевых диуретиков, бисфосфонатов, кальцитонина, перитонеального диализа или гемодиализа с применением диализата, не содержащего кальций. Обязателен контроль содержания электролитов в сыворотке крови (особенно кальция), функции почек и состояния сердца (по данным электрокардиограммы), особенно у пациентов, принимающих дигоксин (или другие препараты наперстянки)."},{"name":"Условия хранения","value":"Хранить при температуре не выше 25 С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Особые указания","value":"Следует обратить внимание на пациентов, принимающих сердечные гликозиды, так как гиперкальциемия может привести к развитию аритмии у таких пациентов.\u003Cbr\u003EСледует обратить внимание на пациентов, принимающих тиазидные диуретики, так как у таких пациентов может увеличиваться риск развития гиперкальциемии.\u003Cbr\u003EЭффективность альфакальцидола в целом сохраняется у пациентов со сниженной функцией печени. При тяжелой печеночной недостаточности концентрация активного метаболита 1,25-дигидроксивитамина D может уменьшаться за счет ослабления процесса гидроксилирования или ввиду снижения энтерогепатической циркуляции. В этом случае может потребоваться назначение препарата в более высоких дозах.\u003Cbr\u003EПри применении препарата у пожилых людей корректировки дозы не требуется.\u003Cbr\u003EПрепарат может способствовать развитию гиперкальциемии, поэтому пациентов следует информировать о клинических симптомах этого состояния (см. раздел \"Передозировка\"). Во время применения препарата Альфа Д3-Тева необходимо регулярно контролировать концентрацию кальция, фосфатов, кальциево-фосфатных соединений, щелочной фосфатазы и уровень паратиреоидного гормона в сыворотке крови.\u003Cbr\u003EКонцентрацию кальция следует определять один раз в неделю или в месяц в зависимости от клинической ситуации. Более частое измерение содержания кальция требуется в начале лечения, особенно при состояниях без значительного поражения костей, например, гипопаратиреозе, и, если содержание кальция в плазме уже повышено, а также на более поздних этапах лечения при наличии признаков восстановления структуры костной ткани. Риск развития гиперкальциемии определяется такими факторами, как: степень деминерализации кости, функциональная способность почек и доза препарата Альфа Д3-Тева®. Появление гиперкальциемии может быть обусловлено тем, что доза препарата не снижается своевременно и адекватно при наличии биохимических признаков восстановления структуры костной ткани (нормализация щелочной фосфатазы в крови). Следует предотвращать развитие длительной гиперкальциемии, особенно при ХПН, ориентируясь на такие показатели, как концентрация в сыворотке крови кальция, щелочной фосфатазы, паратиреоидного гормона, количество кальция, выделяющегося с мочой, рентгенологические и биохимические данные.\u003Cbr\u003EПри развитии гиперкальциемии или стойком повышении уровня кальциево-фосфатных соединений, выходящего за пределы клинической нормы, препарат нужно немедленно отменить, по меньшей мере, до тех пор, пока данные показатели не нормализуются (обычно в течение одной недели), затем прием препарата можно возобновить в дозе, составляющей половину от предыдущей.\u003Cbr\u003EПациенты с выраженным поражением костей (в отличие от пациентов с почечной недостаточностью) могут переносить более высокие дозы препарата без признаков гиперкальциемии. Отсутствие быстрого повышения содержания кальция в сыворотке крови у пациентов с остеомаляцией не обязательно означает, что должна быть повышена доза препарата, так как кальций может проникать в деминерализованную кость за счет его возросшей абсорбции в кишечнике.\u003Cbr\u003EНеобходимо избегать чрезмерного подавления паратиреоидного гормона. Для пациентов, находящихся на диализе, уровень паратиреоидного гормона в сыворотке крови должен соответствовать действующим руководствам по лечению.\u003Cbr\u003EДля предотвращения развития гиперфосфатемии у пациентов с поражением костей почечного генеза, альфакальцидол можно применять вместе с фосфатсвязывающими средствами.\u003Cbr\u003EПри остеопорозе применение препарата Альфа Д3-Тева можно сочетать с эстрогенами и антирезорбтивными препаратами.\u003Cbr\u003EВ состав вспомогательных веществ препарата входит масло арахиса. Пациентам с аллергической реакцией на арахисовое масло и сою препарат противопоказан."},{"name":"Страна производства","value":"Германия"},{"name":"Владелец регистрационного удостоверения","value":"Тева Фармацевтические Предприятия Лтд."}]}},"fullSpecsGrouped":{"16082021644929457943":{"groups":[{"name":"Регистрационные данные","items":[{"name":"Дозировка","value":"0.25 мкг"},{"name":"Количество штук в упаковке","value":"60 шт."}]},{"name":"Тип препарата","items":[{"name":"Рецептурный препарат","value":"да"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Форма выпуска","value":"капсулы"}]},{"name":"Применение и информация","items":[{"name":"Является ЖНВЛС","value":"да"},{"name":"Входит в список ДЛО","value":"да"},{"name":"Действующее вещество","value":"Альфакальцидол"},{"name":"Фармакологическая группа","value":"кальциево-фосфорного обмена регулятор"},{"name":"Фармакологическое действие","value":"Альфакальцидол (1α-гидроксивитамин D3) быстро превращается в печени в 1,25- дигидроксивигамин D3, - активный метаболит витамина D (кальцитриол), который действует как регулятор обмена кальция и фосфора. Повышает абсорбцию кальция и фосфора в кишечнике, увеличивает их реабсорбцию в почках, восстанавливает положительный кальциевый баланс при лечении синдрома кальциевой мальабсорбции и снижает концентрацию в крови паратиреоидного гормона.\u003Cbr\u003EВоздействуя на обе части процесса костного ремоделирования (резорбцию и синтез), альфакальцидол не только увеличивает минерализацию костной ткани, но и повышает ее упругость за счет стимулирования синтеза белков матрикса кости, костных морфогенетических белков, факторов роста кости, что способствует уменьшению частоты развития переломов.\u003Cbr\u003EУ пациентов пожилого возраста на фоне эндокринно-иммунной дисфункции, в том числе дефицита продукции D-гормона (кальцитриола), происходит снижение общей мышечной массы (саркопения) и появление синдрома мышечной слабости (вследствие нарушения нормального функционирования нервно-мышечного аппарата), что сопровождается повышением риска падений и обусловленных этим травм и переломов. В ряде исследований было показано значительное снижение частоты падений пожилых пациентов при применении альфакальцидола. Альфакальцидол стимулирует регенерацию мышечных волокон, что восстанавливает утраченный мышечный тонус."},{"name":"Состав","value":"В 1 капсуле содержится: активное вещество: альфакальцидол 0,25 мкг;\u003Cbr\u003Eвспомогательные вещества: лимонная кислота 0,015 мг, пропилгаллат 0,020 мг, альфа-токоферол 0,020 мг, этанол 1,145 мг, масло арахиса 98,79975 мг; оболочка (.мягкая желатиновая капсула): желатин 48,55 мг, глицерол 85 % 11,70 мг, анидрисорб 85 (сорбитол 25-40 %, сорбитан 20-30 %, маннитол 0-6 %, высшие полиолы 12,5-19 %, вода 15-17 %) 7,92 мг, краситель железа оксид красный (Е172) 0,54/- мг, краситель железа оксид желтый (Е172), титана диоксид (Е171), чернила черные S-1-27794 (шеллак 59,420 %, краситель железа оксид черный (Е172) 24,650 %, бутанол 9,750 %, вода 3,250 %, пропиленгликоль (Е1520) 1,300 %, этанол денатурированный [спирт метилированный] 1,080 %, изопропанол 0.550 %) или S-1-17823 (шеллак 44,467 %, изопропанол 26,882 %, краситель железа оксид черный (Е172) 23,409 %, бутанол 2,242 %, пропиленгликоль (Е1520) 2,000 %, аммиак водный (Е527) 1,000%) следы/следы."},{"name":"Взаимодействие","value":"Индукторы микросомальных ферментов печени (в том числе фенитоин и фенобарбитал) снижают, а ингибиторы - повышают концентрацию альфакальцидола в плазме (возможно изменение его эффективности).\u003Cbr\u003EПри одновременном применении альфакальцидола с препаратами наперстянки повышается риск развития аритмии.\u003Cbr\u003EВсасывание альфакальцидола уменьшается при его совместном применении с колестирамином. колестиполом, минеральным маслом, сукральфатом, антацидами. Для снижения вероятности взаимодействия альфакальцидол следует применять за 1 час до или через 4-6 часов после приема вышеуказанных препаратов.\u003Cbr\u003EКальцитонин, производные этидроновой и памидроновой кислот, пликамицин, галлия нитрат и глюкокортикостероиды снижают эффект альфакальцидола.\u003Cbr\u003EАльфакальцидол увеличивает абсорбцию фосфорсодержащих препаратов и риск возникновения гиперфосфатемии.\u003Cbr\u003EОдновременное применение альфакальцидола с препаратами кальция, тиазидными диуретиками может вызвать гиперкальциемию за счет повышения абсорбции кальция в кишечнике, увеличения его реабсорбции в почках.\u003Cbr\u003EСочетанная терапия магнийсодержащими антацидами и витамином D может вызвать повышение содержания магния в крови, а алюминийсодержащими антацидами - алюминия в крови, особенно при ХПН.\u003Cbr\u003EОдновременное применение различных аналогов витамина D сопровождается аддитивным действием с развитием гиперкальциемии. Препарат Альфа Д3-Тева не следует назначать одновременно с другими препаратами витамина D и его производными."},{"name":"Показания к применению","value":"Заболевания, вызванные нарушением обмена кальция и фосфора вследствие недостаточного эндогенного синтеза 1,25-дигидроксивитамина D3:\u003Cbr\u003E- Остеопороз (в т.ч. постменопаузальный, сенильный, стероидный и др.);\u003Cbr\u003E- остеодистрофия при хронической почечной недостаточности (ХПН);\u003Cbr\u003E- гипопаратиреоз и псевдогипопаратиреоз;\u003Cbr\u003E- витамин D-резистентный рахит и остеомаляция."},{"name":"Противопоказания","value":"- Повышенная чувствительность к компонентам препарата, в том числе к арахису.\u003Cbr\u003E- Гиперкальциемия.\u003Cbr\u003E- Гиперфосфатемия.\u003Cbr\u003E- Гипермагниемия.\u003Cbr\u003E- Гипервитаминоз D.\u003Cbr\u003E- Период беременности и грудного вскармливания.\u003Cbr\u003E- Детский возраст до 12 лет.\u003Cbr\u003E- Длительная иммобилизация.\u003Cbr\u003E- Туберкулез легких (активная форма)."},{"name":"Способ применения и дозы","value":"Препарат принимают внутрь независимо от приема пищи, не разжевывая, запивая достаточным количеством жидкости, однократно в сутки. Длительность курса лечения определяется врачом индивидуально в каждом конкретном случае и зависит от характера заболевания и эффективности терапии.\u003Cbr\u003EВзрослые и дети с массой тела более 20 кг\u003Cbr\u003EНачальная доза - 1 мкг в сутки.\u003Cbr\u003EПоддерживающая доза - 0,25-2 мкг в сутки.\u003Cbr\u003EПри рахите и остеомаляции: от 1 до 3 мкг в сутки; при гипопаратиреозе: 1- 4 мкг в сутки; при остеодистрофии при ХПН: 0,5-2 мкг в сутки; при остеопорозе (в том числе постменопаузальном, сенильном, стероидном и др.): 0,5-1 мкг в сутки.\u003Cbr\u003EНачинать лечение рекомендуется с минимальных доз, контролируя 1 раз в неделю концентрацию кальция и фосфора в плазме крови. Дозу препарата можно повышать на 0,25 или 0,5 мкг/сут до стабилизации биохимических показателей. При достижении минимальной эффективной дозы рекомендуется контролировать концентрацию кальция в плазме крови каждые 3-5 недель."},{"name":"Применение при беременности","value":"Гиперкальциемия у матери в период беременности, связанная с длительной передозировкой витамина D, может вызвать у плода повышение чувствительности к витамину D, подавление функции паращитовидной железы, синдром специфической эльфоподобной внешности, задержку умственного развития, аортальный стеноз.\u003Cbr\u003EПрепарат противопоказан к применению при беременности и в период грудного вскармливания."},{"name":"Побочные действия","value":"Наиболее распространенными нежелательными эффектами препарата Альфа ДЗ-Тева* являются: гиперкальциемия, гиперкальциурия и витамин D-зависимая токсичность.\u003Cbr\u003EНиже приводятся данные о неблагоприятных побочных реакциях, в зависимости от частоты их возникновения. Неблагоприятные побочные реакции, отличные от признаков гиперкальциемии, полученные как отдельные сообщения, также включены.\u003Cbr\u003EЧастота определяется как: очень часто - ≥1/10; часто - ≥1/100 и \u003C1/10; нечасто - ≥1/1000 и \u003C1/100; редко - ≥1/10000 и \u003C1/1000; очень редко - \u003C1/10000 (включая отдельные сообщения); частота неизвестна (невозможно оценить на основании имеющихся данных).\u003Cbr\u003EСо стороны обмена веществ\u003Cbr\u003EОчень часто: гиперкальциемия; нечасто: метастатические кальцификации, гиперфосфатемия, высокое содержание кальциево-фосфатных соединений, анорексия; частота неизвестна: гипермагниемия, сниженный аппетит, снижение массы тела, дегидратация, прекращение роста, альбуминурия, гиперхолестеринемия, повышение уровня ACT и АЛТ в сыворотке крови.\u003Cbr\u003EАллергические реакции\u003Cbr\u003EЧастота неизвестна: реакции гиперчувствительности с такими симптомами, как: лихорадка, озноб, крапивница и отек языка.\u003Cbr\u003EСо стороны нервной системы\u003Cbr\u003EНечасто: головная боль, дизестезия, дисгевзия; очень редко: нарушения психики, галлюцинации, кома, апатия; частота неизвестна: гипертермия.\u003Cbr\u003EСо стороны сердечно-сосудистой системы Редко: тахикардия, повышение артериального давления.\u003Cbr\u003EСо стороны пищеварительной системы Нечасто: тошнота, рвота, боль в животе, запор, диарея, диспепсия; очень редко: острый панкреатит; частота неизвестна: изъязвление языка, изъязвление десен, полидипсия.\u003Cbr\u003EСо стороны кожных покровов Часто: кожный зуд; очень редко: мультиформная эритема, псориаз; частота неизвестна: сыпь (эритематозная, макулопапулезная, пустулезная), эксфолиативный дерматит.\u003Cbr\u003EСо стороны органов чувств Очень редко: кальциноз конъюнктивы и склеры.\u003Cbr\u003EСо стороны дыхательной системы Частота неизвестна: ринит.\u003Cbr\u003EСо стороны мочевыделительной системы Часто: гиперкальциурия, повышение уровня креатинина и мочевины в сыворотке крови; \u003Cbr\u003Eчастота неизвестна: почечная недостаточность, нефрокальциноз, инфекции мочевыводящих путей.Со стороны репродуктивной системы Частота неизвестна: снижение либидо.\u003Cbr\u003EПрочие Редко: кальциноз, астения и повышенная утомляемость."},{"name":"Передозировка","value":"Ранние симптомы гипервитаминоза витамина D (обусловленные гиперкальциемией): запор или диарея, сухость слизистой оболочки полости рта, головная боль, жажда, поллакиурия, никтурия, полиурия, анорексия, металлический привкус во рту, тошнота, рвота, общая слабость, гиперкальциурия.\u003Cbr\u003EПоздние симптомы гипервитаминоза витамина D: боль в костях, помутнение мочи (появление в моче гиалиновых цилиндров), повышение артериального давления, кожный зуд, светобоязнь, гиперемия конъюнктивы, аритмия, сонливость, миалгия, тошнота, рвота, снижение массы тела, редко - изменения психики и настроения, спутанность сознания.\u003Cbr\u003EСимптомы хронической интоксикации витамина D: кальциноз мягких тканей, кровеносных сосудов и внутренних органов (почек, легких), почечная и сердечнососудистая недостаточность, нарушение роста у детей.\u003Cbr\u003EУровень кальция в сыворотке крови нормализуется через 2-7 дней после прекращения приема препарата.\u003Cbr\u003EГиперкальциемия лечится временным прекращением приема альфакальцидола. введением диеты с низким содержанием кальция и прекращением приема добавок кальция.\u003Cbr\u003EВ тяжелых случаях острой случайной передозировки и устойчивой гиперкальциемии следует предпринять общие поддерживающие мероприятия.\u003Cbr\u003EВ случае передозировки следует отменить препарат. В ранние сроки острой передозировки показано промывание желудка и/или прием внутрь минерального масла (вазелинового), способствующего уменьшению всасывания и увеличению выведения препарата через кишечник. В тяжелых случаях (уровень кальция в сыворотке крови \u003E3ммоль/л) может потребоваться проведение поддерживающих лечебных мероприятий - гидратации с введением инфузионных солевых растворов (с целью форсированного диуреза), в некоторых случаях - назначение глюкокортикостероидных препаратов, петлевых диуретиков, бисфосфонатов, кальцитонина, перитонеального диализа или гемодиализа с применением диализата, не содержащего кальций. Обязателен контроль содержания электролитов в сыворотке крови (особенно кальция), функции почек и состояния сердца (по данным электрокардиограммы), особенно у пациентов, принимающих дигоксин (или другие препараты наперстянки)."},{"name":"Условия хранения","value":"Хранить при температуре не выше 25 С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Особые указания","value":"Следует обратить внимание на пациентов, принимающих сердечные гликозиды, так как гиперкальциемия может привести к развитию аритмии у таких пациентов.\u003Cbr\u003EСледует обратить внимание на пациентов, принимающих тиазидные диуретики, так как у таких пациентов может увеличиваться риск развития гиперкальциемии.\u003Cbr\u003EЭффективность альфакальцидола в целом сохраняется у пациентов со сниженной функцией печени. При тяжелой печеночной недостаточности концентрация активного метаболита 1,25-дигидроксивитамина D может уменьшаться за счет ослабления процесса гидроксилирования или ввиду снижения энтерогепатической циркуляции. В этом случае может потребоваться назначение препарата в более высоких дозах.\u003Cbr\u003EПри применении препарата у пожилых людей корректировки дозы не требуется.\u003Cbr\u003EПрепарат может способствовать развитию гиперкальциемии, поэтому пациентов следует информировать о клинических симптомах этого состояния (см. раздел \"Передозировка\"). Во время применения препарата Альфа Д3-Тева необходимо регулярно контролировать концентрацию кальция, фосфатов, кальциево-фосфатных соединений, щелочной фосфатазы и уровень паратиреоидного гормона в сыворотке крови.\u003Cbr\u003EКонцентрацию кальция следует определять один раз в неделю или в месяц в зависимости от клинической ситуации. Более частое измерение содержания кальция требуется в начале лечения, особенно при состояниях без значительного поражения костей, например, гипопаратиреозе, и, если содержание кальция в плазме уже повышено, а также на более поздних этапах лечения при наличии признаков восстановления структуры костной ткани. Риск развития гиперкальциемии определяется такими факторами, как: степень деминерализации кости, функциональная способность почек и доза препарата Альфа Д3-Тева®. Появление гиперкальциемии может быть обусловлено тем, что доза препарата не снижается своевременно и адекватно при наличии биохимических признаков восстановления структуры костной ткани (нормализация щелочной фосфатазы в крови). Следует предотвращать развитие длительной гиперкальциемии, особенно при ХПН, ориентируясь на такие показатели, как концентрация в сыворотке крови кальция, щелочной фосфатазы, паратиреоидного гормона, количество кальция, выделяющегося с мочой, рентгенологические и биохимические данные.\u003Cbr\u003EПри развитии гиперкальциемии или стойком повышении уровня кальциево-фосфатных соединений, выходящего за пределы клинической нормы, препарат нужно немедленно отменить, по меньшей мере, до тех пор, пока данные показатели не нормализуются (обычно в течение одной недели), затем прием препарата можно возобновить в дозе, составляющей половину от предыдущей.\u003Cbr\u003EПациенты с выраженным поражением костей (в отличие от пациентов с почечной недостаточностью) могут переносить более высокие дозы препарата без признаков гиперкальциемии. Отсутствие быстрого повышения содержания кальция в сыворотке крови у пациентов с остеомаляцией не обязательно означает, что должна быть повышена доза препарата, так как кальций может проникать в деминерализованную кость за счет его возросшей абсорбции в кишечнике.\u003Cbr\u003EНеобходимо избегать чрезмерного подавления паратиреоидного гормона. Для пациентов, находящихся на диализе, уровень паратиреоидного гормона в сыворотке крови должен соответствовать действующим руководствам по лечению.\u003Cbr\u003EДля предотвращения развития гиперфосфатемии у пациентов с поражением костей почечного генеза, альфакальцидол можно применять вместе с фосфатсвязывающими средствами.\u003Cbr\u003EПри остеопорозе применение препарата Альфа Д3-Тева можно сочетать с эстрогенами и антирезорбтивными препаратами.\u003Cbr\u003EВ состав вспомогательных веществ препарата входит масло арахиса. Пациентам с аллергической реакцией на арахисовое масло и сою препарат противопоказан."},{"name":"Страна производства","value":"Германия"},{"name":"Владелец регистрационного удостоверения","value":"Тева Фармацевтические Предприятия Лтд."}]}],"transitionId":"tr_6173088570172656870"}}}}
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Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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10 ₽/шт

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    на основе 8 оценок
    Цена 269 ₽ вместо 319
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  • Комбилипен р-р д/ин., 5 шт.
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    Комбилипен р-р д/ин., 5 шт.

    Рейтинг товара: 5 из 5
    на основе 63 оценки
    Цена 337 ₽
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  • Альфадол-ca капс., 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-cn4dwydiv2q/toggleWishlist":{"skuId":"101297043759","productId":228001759,"offerId":"toihADeRTUbufftxO3Rn9w","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQr7vJp8ikwIuBARIxCi9Db21wZXRpdGl2ZUFuYWxvZ3NfTWFya2V0TW9kZWxDYXJkX0Zyb250U25pcHBldDIWCN+P3GwQr/KYrvkCGNXe0AcgnP6jGA==","sign":"8K9W8SXYlSjCHZUJ5ov3ajhYEbPOEpYVSJZfg+jbh1o="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-cn4dwydiv2q/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Альфадол-ca капс., 30 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 772 ₽
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  • Кальцемин адванс таб. п/о, 30 шт.
    –1 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-9h4ylwogem/toggleWishlist":{"skuId":"101319834779","productId":265133303,"offerId":"0vhdTpIlfxcggjAQYALbKA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQr7vJp8ikwIuBARIxCi9Db21wZXRpdGl2ZUFuYWxvZ3NfTWFya2V0TW9kZWxDYXJkX0Zyb250U25pcHBldDIWCPe5tn4Qm/mHufkCGKuLoQYgnP6jGA==","sign":"agtIAkiwj4uvhHeSlv7EPz6iW2ZYOvW2sNYelyqjWrE="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-9h4ylwogem/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Кальцемин адванс таб. п/о, 30 шт.

    Рейтинг товара: 4.9 из 5
    на основе 124 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 779 ₽ вместо 787
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  • Аквадетрим капли д/вн. приема фл.-капельница, 1 шт.
    –11 %
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    Аквадетрим капли д/вн. приема фл.-капельница, 1 шт.

    Рейтинг товара: 4.9 из 5
    на основе 270 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 218 ₽ вместо 220
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  • Кальций д3 никомед форте таб. жев., 60 шт.
    –1 %
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    Кальций д3 никомед форте таб. жев., 60 шт.

    Рейтинг товара: 4.9 из 5
    на основе 51 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 809 ₽ вместо 817
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  • Супрадин таб. п/о, 30 шт.
    –1 %
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    Супрадин таб. п/о, 30 шт.

    Рейтинг товара: 4.9 из 5
    на основе 162 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 110 ₽ вместо 1 121
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  • Мильгамма р-р для в/м введ., 5 шт.
    –16 %
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    Мильгамма р-р для в/м введ., 5 шт.

    Рейтинг товара: 4.9 из 5
    на основе 91 оценка
    Цена 619 ₽ вместо 737
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  • Дигидротахистерол капли д/вн. приема фл., 0.1%, 1 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-0b9bcw662kqf/toggleWishlist":{"skuId":"101309033735","productId":647833395,"offerId":"fPTWaA4jO_UdOkVl_C4FZg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQr7vJp8ikwIuBARIxCi9Db21wZXRpdGl2ZUFuYWxvZ3NfTWFya2V0TW9kZWxDYXJkX0Zyb250U25pcHBldDIXCLPO9LQCEIfa9LP5AhixndAHIJz+oxg=","sign":"bG99qvXOUjARzUwovdKpj8u1cPO+fkndGtcVs1l1o+E="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-0b9bcw662kqf/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Дигидротахистерол капли д/вн. приема фл., 0.1%, 1 шт.

    Рейтинг товара: 4.6 из 5
    на основе 5 оценок
    Цена 477 ₽
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  • Аквадетрим капли д/вн.приема фл.-капельница, 1 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-itvtg9kat3j/toggleWishlist":{"skuId":"101480182736","productId":1463723511,"offerId":"x9Hpch7p5_pIuD00KrwLgQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQr7vJp8ikwIuBARIxCi9Db21wZXRpdGl2ZUFuYWxvZ3NfTWFya2V0TW9kZWxDYXJkX0Zyb250U25pcHBldDIXCPfL+rkFENDnwoX6Ahi53dAHIJz+oxg=","sign":"PM3FpERA4C53KTV4PY5sn/cBeNJ5Df8SMxiWI2VEo9I="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-itvtg9kat3j/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Аквадетрим капли д/вн.приема фл.-капельница, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 110 оценок
    Цена 212 ₽
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Инструкция

Показания к применению

Заболевания, вызванные нарушением обмена кальция и фосфора вследствие недостаточного эндогенного синтеза 1,25-дигидроксивитамина D3:
- Остеопороз (в т.ч. постменопаузальный, сенильный, стероидный и др.);
- остеодистрофия при хронической почечной недостаточности (ХПН);
- гипопаратиреоз и псевдогипопаратиреоз;
- витамин D-резистентный рахит и остеомаляция.

Противопоказания

- Повышенная чувствительность к компонентам препарата, в том числе к арахису.
- Гиперкальциемия.
- Гиперфосфатемия.
- Гипермагниемия.
- Гипервитаминоз D.
- Период беременности и грудного вскармливания.
- Детский возраст до 12 лет.
- Длительная иммобилизация.
- Туберкулез легких (активная форма).

Способ применения и дозы

Препарат принимают внутрь независимо от приема пищи, не разжевывая, запивая достаточным количеством жидкости, однократно в сутки. Длительность курса лечения определяется врачом индивидуально в каждом конкретном случае и зависит от характера заболевания и эффективности терапии.
Взрослые и дети с массой тела более 20 кг
Начальная доза - 1 мкг в сутки.
Поддерживающая доза - 0,25-2 мкг в сутки.
При рахите и остеомаляции: от 1 до 3 мкг в сутки; при гипопаратиреозе: 1- 4 мкг в сутки; при остеодистрофии при ХПН: 0,5-2 мкг в сутки; при остеопорозе (в том числе постменопаузальном, сенильном, стероидном и др.): 0,5-1 мкг в сутки.
Начинать лечение рекомендуется с минимальных доз, контролируя 1 раз в неделю концентрацию кальция и фосфора в плазме крови. Дозу препарата можно повышать на 0,25 или 0,5 мкг/сут до стабилизации биохимических показателей. При достижении минимальной эффективной дозы рекомендуется контролировать концентрацию кальция в плазме крови каждые 3-5 недель.
Полная инструкция
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Альфа Д3-Тева капс.
Альфа Д3-Тева капс., 0.25 мкг, 60 шт.
5.0
(26)
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12 вопросов
Инструкция

595 ₽/уп

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5.0
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У продавца:26 оценок·4 отзыва
У всех продавцов:309 оценок·45 отзывов
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user avatar
4 месяца назад • Елена С. • Куплен на Маркете
Достоинства: покупала маме, она очень довольна препаратом
Недостатки: нет
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5 месяцев назад • МАРГАРИТА --- • Куплен на Маркете
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6 месяцев назад • Сергей З. • Куплен на Маркете
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