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Описание

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Депренорм ОД таб. пролонг. высвоб. п/о плен., 70 мг, 30 шт.

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5.0
(2)
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Количество штук в упаковке, шт.: 30

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Коротко о товаре

Артикул Маркета
3123938800
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
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карбомер 10,97 мг; кремния диоксид коллоидный 6,00 мг; магния стеарат 3,00 мг; целлюлоза микрокристаллическая 189,03 мг:\u003Cbr\u003Eсостав пленочной оболочки: Опадрай прозрачный 2.60 мг, в том числе: гипромеллоза (гидроксипропилметилцеллюлоза) 2.08 мг;макрогол-4000 (полиэтиленгликоль-4000) 0.52 мг; Опадрай II розовый 12,40 мг, в том числе: краситель солнечный закат желтый 0,3150 мг: краситель пунцовый [Понсо 4К] 0,2579 мг; краситель индигокармин 0,1798 мг; поливиниловый спирт 4,9600 мг; макрогол-4000 (полиэтиленгликоль- 4000) 2,5048 мг; тальк 1,8352 мг, титана диоксид 2,3473 мг."},{"name":"Действующее вещество","value":"Триметазидин","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["27144131:28708333"]}}},{"name":"Способ применения и дозы","value":"Внутрь, во время еды. Депренорм ОД принимают по 1 таблетке 70 мг 1 раз в сутки (утром). Таблетки следует принимать целиком, не разжевывая, запивая водой. Продолжительность терапии определяется врачом. \u003Cbr\u003E\nЭффективность терапии оценивают после 3 месяцев применения препарата. При отсутствии эффекта от проводимой терапии прием препарата Депренорм ОД следует прекратить. Максимальная суточная доза триметазидина составляет 70 мг.\u003Cbr\u003E\nПрименение в особых клинических группах пациентов. У пациентов с почечной недостаточностью. У пациентов с почечной недостаточностью средней степени тяжести и тяжелой степени (КК менее 60 мл/мин) применение препарата противопоказано, так как рекомендованная суточная доза триметазидина для таких пациентов составляет 35 мг, у таблеток препарата Депренорм ОД отсутствует риска для обеспечения требуемого режима дозирования. \u003Cbr\u003E\nУ пациентов в возрасте старше 75 лет. У пациентов старше 75 лет может наблюдаться повышенная экспозиция триметазидина из-за возрастного снижения функции почек. Подбор дозы у пациентов старше 75 лет должен проводиться с осторожностью."},{"name":"Побочные действия","value":"Для оценки частоты развития нежелательных реакций использованы следующие критерии: очень часто (\u003E1/10); часто (\u003E1/100, \u003C1/10); нечасто (\u003E1/1000, \u003C1/100); редко (\u003E1/10000, \u003C1/1000); очень редко (\u003C1/10000), частота неизвестна - на основании имеющихся данных нет возможности оценить частоту.\u003Cbr\u003E\nНарушения со стороны крови и лимфатической системы:Частота неизвестна: агранулоцитоз, тромбоцитопения, тромбоцитопеническая пурпура.\u003Cbr\u003E\nНарушения со стороны нервной системы: Часто: головокружение, головная боль; Частота неизвестна: симптомы паркинсонизма (тремор, акинезия, повышенный мышечный тонус), неустойчивость в позе Ромберга и «шаткость» походки, синдром «беспокойных ног», другие связанные с ними двигательные нарушения, обычно обратимые после прекращения терапии), расстройства сна (бессонница, сонливость).\u003Cbr\u003E\nНарушения со стороны органа слуха и лабиринтные нарушения: Частота неизвестна: вертиго.\u003Cbr\u003E\nНарушения со стороны сердца: Редко: ощущение сердцебиения, экстрасистолия, тахикардия.\u003Cbr\u003E\nНарушения со стороны сосудов: Редко: снижение артериального давления, ортостатическая гипотензия (может сопровождаться общей слабостью, головокружением или потерей равновесия, особенно при одновременном приеме гипотензивных препаратов, «приливы» крови к лицу.\u003Cbr\u003E\nНарушения со стороны желудочно-кишечного тракта: Часто: боль в животе, диарея, диспепсия, тошнота, рвота; Частота неизвестна: запор.\u003Cbr\u003E\nНарушения со стороны печени и желчевыводящих путей: Частота неизвестна: гепатит.\u003Cbr\u003E\nНарушения со стороны кожи и подкожных тканей:Часто: кожная сыпь, кожный зуд, крапивница; Частота неизвестна: острый генерализованный экзантематозный пустулез, отек Квинке.\u003Cbr\u003E\nОбщие расстройства и нарушения в месте введения Часто: астения."},{"name":"Фармакологическое действие","value":"Триметазидин в условиях ишемии и гипоксии предотвращает внутриклеточное снижение активности аденозинтрифосфатазы (АТФ), сохраняя энергетический метаболизм и обеспечивая гомеостаз клеток за счет обеспечения нормального функционирования ионных каналов клеточных мембран и трансмембранного натрий-калиевого потока. Он ингибирует бета- окисление жирных кислот, селективно блокируя фермент 3-кетоацил-КоА- тиолазу, что усиливает окисление глюкозы. Клеткам в состоянии ишемии для получения энергии в процессе окисления глюкозы требуется меньше кислорода, чем в процессе бета-окисления жирных кислот.\u003Cbr\u003E\nПереключение энергетического метаболизма клеток с окисления жирных кислот на окисление глюкозы лежит в основе фармакологических эффектов триметазидина. В экспериментальных условиях показано, что препарат: поддерживает энергетический метаболизм сердца и нейросенсорных тканей в условиях ишемии; уменьшает выраженность внутриклеточного ацидоза и изменений трансмембранного потока ионов, возникающих при ишемии; снижает миграцию и инфильтрацию полиядерных нейтрофилов в ишемизированных и реперфузируемых тканях сердца; уменьшает размер повреждений миокарда; не оказывает неблагоприятного воздействия на параметры гемодинамики.\u003Cbr\u003E\nУ пациентов с ишемической болезнью сердца триметазидин действует как метаболический агент, сохраняя в миокарде достаточную внутриклеточную активность высокоэнергетических фосфатов. Антиишемический эффект достигается без влияния на гемодинамику.\u003Cbr\u003E\nУ пациентов со стенокардией триметазидин: увеличивает коронарный резерв, тем самым замедляя наступление ишемии, вызванной физической нагрузкой, начиная с 15-го дня терапии; ограничивает колебания артериального давления, вызванные физической нагрузкой, без значительных изменений частоты сердечных сокращений; снижает частоту приступов стенокардии и потребность в приеме нитроглицерина короткого действия; улучшает сократительную функцию левого желудочка у пациентов с ишемической дисфункцией.\u003Cbr\u003E\nФармакокинетика. При приеме внутрь триметазидин быстро абсорбируется из желудочно-кишечного тракта (ЖКТ), его максимальная концентрация в плазме крови достигается в среднем за 5 часов. Более 24 часов концентрация триметазидина в плазме крови поддерживается на уровнях, превышающих или равных 75% от максимальной.\u003Cbr\u003E\nРавновесное состояние концентрации препарата в крови достигается через 60 часов. Прием пищи не влияет на фармакокинетические свойства триметазидина. Объем распределения составляет 4,8 л/кг. Связь с белками плазмы крови низкая и in vitro составляет 16%.\u003Cbr\u003E\nТриметазидин выводится в основном почками, главным образом, в неизмененном виде. При приеме внутрь в дозе 35 мг период полувыведения у молодых здоровых добровольцев в среднем составляет 7 часов, у пациентов старше 65 лет - 12 часов. Общий почечный клиренс триметазидина прямо коррелирует с клиренсом креатинина (КК), печеночный клиренс снижается с возрастом.\u003Cbr\u003E\nПациенты старше 75 лет. У пациентов старше 75 лет может наблюдаться увеличение экспозиции триметазидина в плазме крови в результате возрастного снижения функции почек. Не было обнаружено никаких особенностей относительно безопасности применения препарата у пациентов старше 75 лет по сравнению с общей популяцией.\u003Cbr\u003E\nПациенты с нарушением функции почек. Экспозиция триметазидина в плазме крови была увеличена примерно в 2,4 раза у пациентов с нарушением функции почек умеренной степени тяжести (КК 30-60 мл/мин), и примерно в 4 раза - у пациентов с нарушением функции почек тяжелой степени (КК менее 30 мл/мин) по сравнению со здоровыми добровольцами с нормальной функцией почек. Не было обнаружено никаких особенностей относительно безопасности применения препарата у пациентов с нарушением функции почек по сравнению с общей популяцией.\u003Cbr\u003E\nПрименение у детей и подростков. Фармакокинетика триметазидина у детей и подростков до 18 лет не изучалась."},{"name":"Фармакологическая группа","value":"антигипоксантное средство"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"При температуре не выше 25 °C во вторичной упаковке (пачке картонной). Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Имеется ограниченная информация о передозировке триметазидина. В случае передозировки следует проводить симптоматическую терапию."},{"name":"Применение при беременности и кормлении грудью","value":"Применение триметазидина в период беременности противопоказано. Клинические данные об опыте применения триметазидина у беременных отсутствуют. Исследования на животных не выявили наличия тератогенного действия. Потенциальный риск применения триметазидина во время беременности у человека неизвестен. Неизвестно, проникает ли триметазидин или его метаболиты в грудное молоко. Применение триметазидина в период грудного вскармливания противопоказано. В случае необходимости применения препарата Депренорм ОД - грудное вскармливание следует прекратить."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В связи с возможным развитием головокружения и других нежелательных реакций на фоне приема препарата следует соблюдать осторожность при управлении транспортными средствами и механизмами, а также занятием другими видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"Триметазидин не предназначен для купирования приступов стенокардии и не показан для начального курса терапии нестабильной стенокардии или инфаркта миокарда на догоспитальном этапе или в первые дни после госпитализации пациента. В случае развития приступа стенокардии следует пересмотреть и адаптировать лечение (лекарственную терапию или проведение процедуры реваскуляризации). Триметазидин может вызывать или ухудшать симптомы паркинсонизма (тремор, акинезию, повышение мышечного тонуса), поэтому требуется тщательное врачебное наблюдение таких пациентов, особенно пожилого возраста. В сомнительных случаях пациенты должны быть направлены к врачу-неврологу для соответствующего обследования.\u003Cbr\u003E\nПри появлении двигательных нарушений, таких как симптомы паркинсонизма, синдром «беспокойных ног», тремор, неустойчивость в позе Ромберга и «шаткость» походки, прием триметазидина следует прекратить. Такие случаи редки и симптомы обычно проходят после прекращения терапии (у большинства пациентов в течение 4 месяцев после отмены препарата). Если симптомы паркинсонизма сохраняются более 4 месяцев после прекращения приема препарата, необходима консультация врача-невролога. Могут отмечаться случаи падения, связанные с неустойчивостью в позе Ромберга и «шаткостью» походки или выраженным снижением артериального давления, особенно у пациентов, принимающих гипотензивные препараты. Тщательное врачебное наблюдение требуется при применении триметазидина у пациентов с печеночной недостаточностью тяжелой степени и у пациентов старше 75 лет (в связи с возможным повышением его экспозиции из-за возрастного снижения функции почек)."},{"name":"Взаимодействие","value":"Случаи лекарственного взаимодействия не описаны."},{"name":"Регистрационный номер","value":"ЛП-002091"},{"name":"Дата государственной регистрации","value":"30.07.2019"},{"name":"Владелец регистрационного удостоверения","value":"Канонфарма продакшн","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["34324371:35649313","7893318:16146766"]}}},{"name":"Изготовитель","value":"Канонфарма продакшн"},{"name":"Фасовщик","value":"Канонфарма продакшн"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Депренорм","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["17796364:18017668"]}}},{"name":"Срок годности","value":"36 мес."}]}},"fullSpecsGrouped":{"1369117454215876559":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"кровеносные сосуды, сердце"},{"name":"Назначение","value":"ишемическая болезнь сердца, стенокардия"},{"name":"Показания к применению","value":"Длительная терапия ишемической болезни сердца: профилактика приступов стабильной стенокардии в составе моно- или комбинированной терапии."},{"name":"Противопоказания","value":"-Повышенная чувствительность к триметазидину или любому из вспомогательных веществ препарата;\u003Cbr\u003E\n-Болезнь Паркинсона, симптомы паркинсонизма, тремор, синдром «беспокойных ног» и другие, связанные с ними двигательные нарушения;\u003Cbr\u003E\n-Почечная недостаточность средней степени тяжести и тяжелой степени (клиренс креатинина (КК) менее 60 мл/мин);\u003Cbr\u003E\n-Беременность;\u003Cbr\u003E\n-Период грудного вскармливания;\u003Cbr\u003E\n-Возраст до 18 лет (отсутствуют данные по эффективности и безопасности применения триметазидина в данной возрастной категории)."},{"name":"Состав","value":"1 таблетка с пролонгированным высвобождением,покрытая пленочной оболочкой, содержит: действующее вещество: триметазидина дигидрохлорид 70,00 мг;\u003Cbr\u003Eвспомогательные вещества: гипромеллоза (гидроксипропилметилцеллюлоза) 171,00 мг; карбомер 10,97 мг; кремния диоксид коллоидный 6,00 мг; магния стеарат 3,00 мг; целлюлоза микрокристаллическая 189,03 мг:\u003Cbr\u003Eсостав пленочной оболочки: Опадрай прозрачный 2.60 мг, в том числе: гипромеллоза (гидроксипропилметилцеллюлоза) 2.08 мг;макрогол-4000 (полиэтиленгликоль-4000) 0.52 мг; Опадрай II розовый 12,40 мг, в том числе: краситель солнечный закат желтый 0,3150 мг: краситель пунцовый [Понсо 4К] 0,2579 мг; краситель индигокармин 0,1798 мг; поливиниловый спирт 4,9600 мг; макрогол-4000 (полиэтиленгликоль- 4000) 2,5048 мг; тальк 1,8352 мг, титана диоксид 2,3473 мг."},{"name":"Действующее вещество","value":"Триметазидин"},{"name":"Способ применения и дозы","value":"Внутрь, во время еды. Депренорм ОД принимают по 1 таблетке 70 мг 1 раз в сутки (утром). Таблетки следует принимать целиком, не разжевывая, запивая водой. Продолжительность терапии определяется врачом. \u003Cbr\u003E\nЭффективность терапии оценивают после 3 месяцев применения препарата. При отсутствии эффекта от проводимой терапии прием препарата Депренорм ОД следует прекратить. Максимальная суточная доза триметазидина составляет 70 мг.\u003Cbr\u003E\nПрименение в особых клинических группах пациентов. У пациентов с почечной недостаточностью. У пациентов с почечной недостаточностью средней степени тяжести и тяжелой степени (КК менее 60 мл/мин) применение препарата противопоказано, так как рекомендованная суточная доза триметазидина для таких пациентов составляет 35 мг, у таблеток препарата Депренорм ОД отсутствует риска для обеспечения требуемого режима дозирования. \u003Cbr\u003E\nУ пациентов в возрасте старше 75 лет. У пациентов старше 75 лет может наблюдаться повышенная экспозиция триметазидина из-за возрастного снижения функции почек. Подбор дозы у пациентов старше 75 лет должен проводиться с осторожностью."},{"name":"Побочные действия","value":"Для оценки частоты развития нежелательных реакций использованы следующие критерии: очень часто (\u003E1/10); часто (\u003E1/100, \u003C1/10); нечасто (\u003E1/1000, \u003C1/100); редко (\u003E1/10000, \u003C1/1000); очень редко (\u003C1/10000), частота неизвестна - на основании имеющихся данных нет возможности оценить частоту.\u003Cbr\u003E\nНарушения со стороны крови и лимфатической системы:Частота неизвестна: агранулоцитоз, тромбоцитопения, тромбоцитопеническая пурпура.\u003Cbr\u003E\nНарушения со стороны нервной системы: Часто: головокружение, головная боль; Частота неизвестна: симптомы паркинсонизма (тремор, акинезия, повышенный мышечный тонус), неустойчивость в позе Ромберга и «шаткость» походки, синдром «беспокойных ног», другие связанные с ними двигательные нарушения, обычно обратимые после прекращения терапии), расстройства сна (бессонница, сонливость).\u003Cbr\u003E\nНарушения со стороны органа слуха и лабиринтные нарушения: Частота неизвестна: вертиго.\u003Cbr\u003E\nНарушения со стороны сердца: Редко: ощущение сердцебиения, экстрасистолия, тахикардия.\u003Cbr\u003E\nНарушения со стороны сосудов: Редко: снижение артериального давления, ортостатическая гипотензия (может сопровождаться общей слабостью, головокружением или потерей равновесия, особенно при одновременном приеме гипотензивных препаратов, «приливы» крови к лицу.\u003Cbr\u003E\nНарушения со стороны желудочно-кишечного тракта: Часто: боль в животе, диарея, диспепсия, тошнота, рвота; Частота неизвестна: запор.\u003Cbr\u003E\nНарушения со стороны печени и желчевыводящих путей: Частота неизвестна: гепатит.\u003Cbr\u003E\nНарушения со стороны кожи и подкожных тканей:Часто: кожная сыпь, кожный зуд, крапивница; Частота неизвестна: острый генерализованный экзантематозный пустулез, отек Квинке.\u003Cbr\u003E\nОбщие расстройства и нарушения в месте введения Часто: астения."},{"name":"Фармакологическое действие","value":"Триметазидин в условиях ишемии и гипоксии предотвращает внутриклеточное снижение активности аденозинтрифосфатазы (АТФ), сохраняя энергетический метаболизм и обеспечивая гомеостаз клеток за счет обеспечения нормального функционирования ионных каналов клеточных мембран и трансмембранного натрий-калиевого потока. Он ингибирует бета- окисление жирных кислот, селективно блокируя фермент 3-кетоацил-КоА- тиолазу, что усиливает окисление глюкозы. Клеткам в состоянии ишемии для получения энергии в процессе окисления глюкозы требуется меньше кислорода, чем в процессе бета-окисления жирных кислот.\u003Cbr\u003E\nПереключение энергетического метаболизма клеток с окисления жирных кислот на окисление глюкозы лежит в основе фармакологических эффектов триметазидина. В экспериментальных условиях показано, что препарат: поддерживает энергетический метаболизм сердца и нейросенсорных тканей в условиях ишемии; уменьшает выраженность внутриклеточного ацидоза и изменений трансмембранного потока ионов, возникающих при ишемии; снижает миграцию и инфильтрацию полиядерных нейтрофилов в ишемизированных и реперфузируемых тканях сердца; уменьшает размер повреждений миокарда; не оказывает неблагоприятного воздействия на параметры гемодинамики.\u003Cbr\u003E\nУ пациентов с ишемической болезнью сердца триметазидин действует как метаболический агент, сохраняя в миокарде достаточную внутриклеточную активность высокоэнергетических фосфатов. Антиишемический эффект достигается без влияния на гемодинамику.\u003Cbr\u003E\nУ пациентов со стенокардией триметазидин: увеличивает коронарный резерв, тем самым замедляя наступление ишемии, вызванной физической нагрузкой, начиная с 15-го дня терапии; ограничивает колебания артериального давления, вызванные физической нагрузкой, без значительных изменений частоты сердечных сокращений; снижает частоту приступов стенокардии и потребность в приеме нитроглицерина короткого действия; улучшает сократительную функцию левого желудочка у пациентов с ишемической дисфункцией.\u003Cbr\u003E\nФармакокинетика. При приеме внутрь триметазидин быстро абсорбируется из желудочно-кишечного тракта (ЖКТ), его максимальная концентрация в плазме крови достигается в среднем за 5 часов. Более 24 часов концентрация триметазидина в плазме крови поддерживается на уровнях, превышающих или равных 75% от максимальной.\u003Cbr\u003E\nРавновесное состояние концентрации препарата в крови достигается через 60 часов. Прием пищи не влияет на фармакокинетические свойства триметазидина. Объем распределения составляет 4,8 л/кг. Связь с белками плазмы крови низкая и in vitro составляет 16%.\u003Cbr\u003E\nТриметазидин выводится в основном почками, главным образом, в неизмененном виде. При приеме внутрь в дозе 35 мг период полувыведения у молодых здоровых добровольцев в среднем составляет 7 часов, у пациентов старше 65 лет - 12 часов. Общий почечный клиренс триметазидина прямо коррелирует с клиренсом креатинина (КК), печеночный клиренс снижается с возрастом.\u003Cbr\u003E\nПациенты старше 75 лет. У пациентов старше 75 лет может наблюдаться увеличение экспозиции триметазидина в плазме крови в результате возрастного снижения функции почек. Не было обнаружено никаких особенностей относительно безопасности применения препарата у пациентов старше 75 лет по сравнению с общей популяцией.\u003Cbr\u003E\nПациенты с нарушением функции почек. Экспозиция триметазидина в плазме крови была увеличена примерно в 2,4 раза у пациентов с нарушением функции почек умеренной степени тяжести (КК 30-60 мл/мин), и примерно в 4 раза - у пациентов с нарушением функции почек тяжелой степени (КК менее 30 мл/мин) по сравнению со здоровыми добровольцами с нормальной функцией почек. Не было обнаружено никаких особенностей относительно безопасности применения препарата у пациентов с нарушением функции почек по сравнению с общей популяцией.\u003Cbr\u003E\nПрименение у детей и подростков. Фармакокинетика триметазидина у детей и подростков до 18 лет не изучалась."},{"name":"Фармакологическая группа","value":"антигипоксантное средство"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"При температуре не выше 25 °C во вторичной упаковке (пачке картонной). Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Имеется ограниченная информация о передозировке триметазидина. В случае передозировки следует проводить симптоматическую терапию."},{"name":"Применение при беременности и кормлении грудью","value":"Применение триметазидина в период беременности противопоказано. Клинические данные об опыте применения триметазидина у беременных отсутствуют. Исследования на животных не выявили наличия тератогенного действия. Потенциальный риск применения триметазидина во время беременности у человека неизвестен. Неизвестно, проникает ли триметазидин или его метаболиты в грудное молоко. Применение триметазидина в период грудного вскармливания противопоказано. В случае необходимости применения препарата Депренорм ОД - грудное вскармливание следует прекратить."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В связи с возможным развитием головокружения и других нежелательных реакций на фоне приема препарата следует соблюдать осторожность при управлении транспортными средствами и механизмами, а также занятием другими видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"Триметазидин не предназначен для купирования приступов стенокардии и не показан для начального курса терапии нестабильной стенокардии или инфаркта миокарда на догоспитальном этапе или в первые дни после госпитализации пациента. В случае развития приступа стенокардии следует пересмотреть и адаптировать лечение (лекарственную терапию или проведение процедуры реваскуляризации). Триметазидин может вызывать или ухудшать симптомы паркинсонизма (тремор, акинезию, повышение мышечного тонуса), поэтому требуется тщательное врачебное наблюдение таких пациентов, особенно пожилого возраста. В сомнительных случаях пациенты должны быть направлены к врачу-неврологу для соответствующего обследования.\u003Cbr\u003E\nПри появлении двигательных нарушений, таких как симптомы паркинсонизма, синдром «беспокойных ног», тремор, неустойчивость в позе Ромберга и «шаткость» походки, прием триметазидина следует прекратить. Такие случаи редки и симптомы обычно проходят после прекращения терапии (у большинства пациентов в течение 4 месяцев после отмены препарата). Если симптомы паркинсонизма сохраняются более 4 месяцев после прекращения приема препарата, необходима консультация врача-невролога. Могут отмечаться случаи падения, связанные с неустойчивостью в позе Ромберга и «шаткостью» походки или выраженным снижением артериального давления, особенно у пациентов, принимающих гипотензивные препараты. Тщательное врачебное наблюдение требуется при применении триметазидина у пациентов с печеночной недостаточностью тяжелой степени и у пациентов старше 75 лет (в связи с возможным повышением его экспозиции из-за возрастного снижения функции почек)."},{"name":"Взаимодействие","value":"Случаи лекарственного взаимодействия не описаны."},{"name":"Регистрационный номер","value":"ЛП-002091"},{"name":"Дата государственной регистрации","value":"30.07.2019"},{"name":"Владелец регистрационного удостоверения","value":"Канонфарма продакшн"},{"name":"Изготовитель","value":"Канонфарма продакшн"},{"name":"Фасовщик","value":"Канонфарма продакшн"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Депренорм"},{"name":"Срок годности","value":"36 мес."}]}],"transitionId":"tr_6347171195689519468"}}}}
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Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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540 ₽

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ЕАПТЕКА
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  • Предуктал ОД капс. с пролонг. высвоб., 80 мг, 30 шт.
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    Предуктал ОД капс. с пролонг. высвоб., 80 мг, 30 шт.

    Рейтинг товара: 4.7 из 5
    на основе 26 оценок
    Цена 1 131 ₽
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  • Депренорм МВ таб. с пролонг. высвоб., п/о плен., 35 мг, 60 шт.
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    Депренорм МВ таб. с пролонг. высвоб., п/о плен., 35 мг, 60 шт.

    Рейтинг товара: 4.9 из 5
    на основе 11 оценок
    Цена 435 ₽
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  • Триметазидин МВ таб. модиф. высвоб. п/о плен., 35 мг, 60 шт.
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    Триметазидин МВ таб. модиф. высвоб. п/о плен., 35 мг, 60 шт.

    Рейтинг товара: 4.5 из 5
    на основе 31 оценка
    Цена 224 ₽
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  • Тримектал ОД таб. пролонг. действ. п/о плен., 80 мг, 30 шт.
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    Тримектал ОД таб. пролонг. действ. п/о плен., 80 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 12 оценок
    Цена 809 ₽
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  • Триметазидин мв таб. пролонг. высвоб. п/о плен., 35 мг, 30 шт.
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    Триметазидин мв таб. пролонг. высвоб. п/о плен., 35 мг, 30 шт.

    Рейтинг товара: 3.7 из 5
    на основе 3 оценки
    Цена 257 ₽
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  • Верапамил таб. п/о плен., 40 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-4etclkyzx4b/toggleWishlist":{"skuId":"228042234","productId":1401075599,"offerId":"82VwWWQcFaPK7O7D__NvBA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ39TYx5Slj8ZbEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIj++KnAUQ+svebBjk4NAHINfcwQc=","sign":"gMCQLb1Q6FX55Uq7x5KkpzFp13IBnGIlX04lNbUV/FI="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-4etclkyzx4b/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Верапамил таб. п/о плен., 40 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 6 оценок
    Цена 55 ₽
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-4etclkyzx4b/addToCartButton":{"offerId":"82VwWWQcFaPK7O7D__NvBA","skuId":"228042234","pendingCartItem":{"productId":1401075599,"offerId":"82VwWWQcFaPK7O7D__NvBA","showPlaceId":"OTNDnItfwRMjN9MRHuEMMnBAXXL8rqSQPp7IM8P3cfnLouE1JMzlY-E8igVdypnu76wz0u81x_bd581IbAsTZPxFd1LankRSDbvWUmJiF4bdjvnmQLG8ngwl9qA63nrYTGhSP9SyIwnPm6qKbo_5ywau_EbSPTpwl4iVJN2KMBJIWp8hepIY3ZcEB8Qx5jNonmsWK_EmD7KrQUkLCiLD2Q,,","feeShow":"OTNDnItfwRMjN9MRHuEMMnBAXXL8rqSQPp7IM8P3cfnLouE1JMzlY-E8igVdypnu76wz0u81x_bd581IbAsTZPxFd1LankRSDbvWUmJiF4bdjvnmQLG8ngwl9qA63nrYTGhSP9SyIwnPm6qKbo_5ywau_EbSPTpwl4iVJN2KMBJIWp8hepIY3ZcEB8Qx5jNonmsWK_EmD7KrQUkLCiLD2Q,,","skuId":"228042234","shopId":55106433,"price":{"applicablePriceDiscounts":[],"value":"55","currency":"RUR"},"hid":"15756887","name":"Верапамил таб. п/о плен., 40 мг, 30 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  • Фозинап таб., 10 мг, 28 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-pl2roo30r8/toggleWishlist":{"skuId":"186879985","productId":1401075537,"offerId":"vx68bM8IA-0ikxWoPnURWw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ39TYx5Slj8ZbEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI0e6KnAUQ8Z+OWRjOwtkHINfcwQc=","sign":"QnHoISBjn2K8ASeVMHSHL5ki4vTxQas6tY20g7U+Hg4="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-pl2roo30r8/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Фозинап таб., 10 мг, 28 шт.

    Рейтинг товара: 4.8 из 5
    на основе 11 оценок
    Цена 270 ₽
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-pl2roo30r8/addToCartButton":{"offerId":"vx68bM8IA-0ikxWoPnURWw","skuId":"186879985","pendingCartItem":{"productId":1401075537,"offerId":"vx68bM8IA-0ikxWoPnURWw","showPlaceId":"OTNDnItfwRMjN9MRHuEMMnBAXXL8rqSQTHmfhqmENV57j1_MWkcIiSAvOuzMN_1I_di2Ac2c0OyQcnJFdODSNZRNyRj07pDsvp7RnYcYOuNW8JzKHOgiWMWqw24ji6_npeHDlwFff0zOrbY624i9r6gjpNFvImB2ju9exwF8eXX7txmeaKQtXU2WkWV1N0pIzx08lBvamObnyClfaCRGbw,,","feeShow":"OTNDnItfwRMjN9MRHuEMMnBAXXL8rqSQTHmfhqmENV57j1_MWkcIiSAvOuzMN_1I_di2Ac2c0OyQcnJFdODSNZRNyRj07pDsvp7RnYcYOuNW8JzKHOgiWMWqw24ji6_npeHDlwFff0zOrbY624i9r6gjpNFvImB2ju9exwF8eXX7txmeaKQtXU2WkWV1N0pIzx08lBvamObnyClfaCRGbw,,","skuId":"186879985","shopId":77075781,"price":{"applicablePriceDiscounts":[],"value":"270","currency":"RUR"},"hid":"15756887","name":"Фозинап таб., 10 мг, 28 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  • Триметазидин таб. п/о плен., 20 мг, 60 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-b7ee1fi1pjf/toggleWishlist":{"skuId":"101775133729","productId":660020030,"offerId":"8s5ylH1EWhlY1yQm42mHNA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ39TYx5Slj8ZbEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIvrbcugIQoZiVkvsCGM7C2Qcg19zBBw==","sign":"30Qmn0N4Ikyqvw9HuYdl2gjBCqXhRhScIVQ4Vrjpx40="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-b7ee1fi1pjf/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Триметазидин таб. п/о плен., 20 мг, 60 шт.

    Рейтинг товара: 5 из 5
    на основе 42 оценки
    Цена 212 ₽
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-b7ee1fi1pjf/addToCartButton":{"offerId":"8s5ylH1EWhlY1yQm42mHNA","skuId":"101775133729","pendingCartItem":{"productId":660020030,"offerId":"8s5ylH1EWhlY1yQm42mHNA","showPlaceId":"OTNDnItfwRMjN9MRHuEMMnBAXXL8rqSQq5LzUgOrjxmq9fqtN5qD8FrWyBkhplHH6wzGJyscYPsRq-QWrCu50gJ8tBFHRlZ_k_trV1PvZ03OXmgzs3je6wOBG6wDzMxNFWtoXb8akSUIY1cUW09dBNQlNZFpVzywcZtpHUWZ6FpzDVLMvEB_V09frGb6q3gkbvIYCptk_FCXEHWkGEYdhQ,,","feeShow":"OTNDnItfwRMjN9MRHuEMMnBAXXL8rqSQq5LzUgOrjxmq9fqtN5qD8FrWyBkhplHH6wzGJyscYPsRq-QWrCu50gJ8tBFHRlZ_k_trV1PvZ03OXmgzs3je6wOBG6wDzMxNFWtoXb8akSUIY1cUW09dBNQlNZFpVzywcZtpHUWZ6FpzDVLMvEB_V09frGb6q3gkbvIYCptk_FCXEHWkGEYdhQ,,","skuId":"101775133729","shopId":55106433,"price":{"applicablePriceDiscounts":[],"value":"212","currency":"RUR"},"hid":"15756887","name":"Триметазидин таб. п/о плен., 20 мг, 60 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  • Тримектал МВ таб. модиф. высвоб. п/о плен., 35 мг, 60 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-d042l0wih2q/toggleWishlist":{"skuId":"186882172","productId":1401075530,"offerId":"NSIAfMeSfGlgt-DKQFB0hg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ39TYx5Slj8ZbEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIyu6KnAUQ/LCOWRi01YcEINfcwQc=","sign":"c5iH2LFjtU5l1wwStN9+Swxww35EGRQOVIrN/FLTSR4="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-d042l0wih2q/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Тримектал МВ таб. модиф. высвоб. п/о плен., 35 мг, 60 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 660 ₽
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  • Эврензо таб. п/пл. об., 20 мг, 12 шт.
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    Эврензо таб. п/пл. об., 20 мг, 12 шт.

    Цена 4 618 ₽
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  • Валсартан Канон таб. п/о плен., 160 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-26sf1rjx0ps/toggleWishlist":{"skuId":"101817112900","productId":1701610226,"offerId":"d5gTxpHhfNFGebjSMTX-5Q","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ39TYx5Slj8ZbEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI8oWyqwYQxLKXpvsCGM7C2Qcg19zBBw==","sign":"pVamFLm1q0lFAa8+mhNaIcq9MgL1a3Y4//AYrYRwIrY="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-26sf1rjx0ps/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Валсартан Канон таб. п/о плен., 160 мг, 30 шт.

    Рейтинг товара: 4.6 из 5
    на основе 15 оценок
    Цена 272 ₽
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-26sf1rjx0ps/addToCartButton":{"offerId":"d5gTxpHhfNFGebjSMTX-5Q","skuId":"101817112900","pendingCartItem":{"productId":1701610226,"offerId":"d5gTxpHhfNFGebjSMTX-5Q","showPlaceId":"OTNDnItfwRMjN9MRHuEMMnBAXXL8rqSQlKGnMKEgItREre-K0Hur01IuCBWjIe-GAUyJeXhGjF_BMI-E6YzHsxb_tFqbseuZZLot3aAj2r1zLkZ7hsMP_G7QHelp1VClUFCDkfdbG8hCwWZgmVwuH5K22qIle7-6tB8LNTc2D63lO2E30vaQad__NwLJ6hErj2RtZatXmdUlGX9C_vDcow,,","feeShow":"OTNDnItfwRMjN9MRHuEMMnBAXXL8rqSQlKGnMKEgItREre-K0Hur01IuCBWjIe-GAUyJeXhGjF_BMI-E6YzHsxb_tFqbseuZZLot3aAj2r1zLkZ7hsMP_G7QHelp1VClUFCDkfdbG8hCwWZgmVwuH5K22qIle7-6tB8LNTc2D63lO2E30vaQad__NwLJ6hErj2RtZatXmdUlGX9C_vDcow,,","skuId":"101817112900","shopId":77075781,"price":{"applicablePriceDiscounts":[],"value":"272","currency":"RUR"},"hid":"15756887","name":"Валсартан Канон таб. п/о плен., 160 мг, 30 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  • Пропафенон таб. п/о плен., 150 мг, 40 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-00dbl4hx7eymv/toggleWishlist":{"skuId":"457101627","productId":1401075884,"offerId":"HfIxqj8fL_wcCGev6nzsOA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ39TYx5Slj8ZbEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIrPGKnAUQu6L72QEY5ODQByDX3MEH","sign":"t4XsXAYS8E8VQ1QMEYU4ijDu4zn0n06ET78UuQ+Ymqw="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-00dbl4hx7eymv/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Пропафенон таб. п/о плен., 150 мг, 40 шт.

    Рейтинг товара: 4.4 из 5
    на основе 22 оценки
    Цена 380 ₽
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Инструкция

Показания к применению

Длительная терапия ишемической болезни сердца: профилактика приступов стабильной стенокардии в составе моно- или комбинированной терапии.

Противопоказания

-Повышенная чувствительность к триметазидину или любому из вспомогательных веществ препарата;
-Болезнь Паркинсона, симптомы паркинсонизма, тремор, синдром «беспокойных ног» и другие, связанные с ними двигательные нарушения;
-Почечная недостаточность средней степени тяжести и тяжелой степени (клиренс креатинина (КК) менее 60 мл/мин);
-Беременность;
-Период грудного вскармливания;
-Возраст до 18 лет (отсутствуют данные по эффективности и безопасности применения триметазидина в данной возрастной категории).

Способ применения и дозы

Внутрь, во время еды. Депренорм ОД принимают по 1 таблетке 70 мг 1 раз в сутки (утром). Таблетки следует принимать целиком, не разжевывая, запивая водой. Продолжительность терапии определяется врачом.
Эффективность терапии оценивают после 3 месяцев применения препарата. При отсутствии эффекта от проводимой терапии прием препарата Депренорм ОД следует прекратить. Максимальная суточная доза триметазидина составляет 70 мг.
Применение в особых клинических группах пациентов. У пациентов с почечной недостаточностью. У пациентов с почечной недостаточностью средней степени тяжести и тяжелой степени (КК менее 60 мл/мин) применение препарата противопоказано, так как рекомендованная суточная доза триметазидина для таких пациентов составляет 35 мг, у таблеток препарата Депренорм ОД отсутствует риска для обеспечения требуемого режима дозирования.
У пациентов в возрасте старше 75 лет. У пациентов старше 75 лет может наблюдаться повышенная экспозиция триметазидина из-за возрастного снижения функции почек. Подбор дозы у пациентов старше 75 лет должен проводиться с осторожностью.
Полная инструкция
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Депренорм ОД таб. пролонг. высвоб. п/о плен.
Депренорм ОД таб. пролонг. высвоб. п/о плен., 70 мг, 30 шт.
5.0
(2)
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3 вопроса
Инструкция

540 ₽

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5.0
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У продавца:2 оценки·1 отзыв
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5 месяцев назад • Ю • Куплен на Маркете
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