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Описание

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Глауламид гл. капли, 20 мг/мл + 5 мг/мл, 5 мл

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5.0
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Коротко о товаре

Артикул Маркета
4696875975
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
{"widgets":{"@card/SpecsList":{"/content/page/fancyPage/productSpecsList":{"wrapperProps":{"margins":{"top":4,"bottom":4}},"specsLimit":5,"title":"Коротко о товаре","titleSize":"14","type":"minimal","offset":"s","isHealthCategory":true,"forceShowWidget":true,"withFridge":true}}},"meta":{"/content/page/fancyPage/productSpecsList":{"name":"@card/SpecsList"}},"collections":{"minimalSpecs":{"6515487407809839089":{"specItems":[{"name":"Артикул Маркета","value":"4696875975","withCopyValueButton":true},{"name":"тип препарата","value":"рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"назначение","value":"открытоугольная глаукома, офтальмогипертензия","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["36476390:36618538,36617871"]}}},{"name":"действующее вещество","value":"Дорзоламид+Тимолол","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["27144131:36090564"]}}},{"name":"возраст","value":"от 18 лет"},{"name":"форма выпуска","value":"капли"},{"name":"страна-производитель","value":"Россия"}]}},"compactSpecs":{"6515487407809839089":{"specItems":[{"name":"Артикул Маркета","value":"4696875975","withCopyValueButton":true},{"name":"Тип препарата","value":"Рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"Действующее вещество","value":"Дорзоламид+Тимолол","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["27144131:36090564"]}}},{"name":"Возраст","value":"От 18 лет"},{"name":"Форма выпуска","value":"Капли"}]}},"fullSpecs":{"6515487407809839089":{"specItems":[{"name":"Тип препарата","value":"лекарственный препарат","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["34324371:35649313"]}}},{"name":"Рецептурный препарат","value":"да","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["27272850:1,0"]}}},{"name":"Органы и системы","value":"глаза","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["34045610:34516019"]}}},{"name":"Назначение","value":"открытоугольная глаукома, офтальмогипертензия","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["36476390:36618538,36617871"]}}},{"name":"Показания к применению","value":"Препарат применяется для лечения повышенного внутриглазного давления при открытоугольной глаукоме и псевдоэксфолиативиой глаукоме при недостаточной эффективности монотерапии или офтальмогипертензии при недостаточном ответе на лечение бета-адреноблокаторами."},{"name":"Противопоказания","value":"- Гиперреактивность дыхательных путей, бронхиальная астма, бронхиальная астма в анамнезе, тяжелая хроническая обструктивная болезнь легких;\u003Cbr\u003E\n- синусовая брадикардия, синдром слабости синусового узла, синоатриальная блокада, антриовентрикулярная блокада II-III степени без кардиостимулятора, выраженная сердечная недостаточность, кардиогенный шок;\u003Cbr\u003E\n- тяжелая почечная недостаточность (КК меньше 30 мл/мин) или гиперхлоремический ацидоз;\u003Cbr\u003E\n- дистрофические процессы в роговице;\u003Cbr\u003E\n- беременность и период кормления грудью;\u003Cbr\u003E\n- повышенная чувствительность к любому компоненту препарата;\u003Cbr\u003E\n- детский возраст до 18 лет (в связи с недостаточной изученностью эффективности и безопасности)."},{"name":"Состав","value":"1 мл раствора содержит: действующие вещества: дорзоламида гидрохлорид - 22,26 мг (в пересчете на дорзоламид основание - 20,00 мг), тимолола малеат - 6,83 мг (в пересчете на тимолол - 5,00 мг); вспомогательные вещества: бензалкония хлорид 50 % раствор - 0,15 мг (эквивалентный 0,075 мг бензалкония хлорида), маннитол - 16,00 мг, гиэтеллоза (гидроксиэтилцеллюлоза) - 4,75 мг, натрия цитрат - 2,94 мг, натрия гидроксида раствор 1 М - до pH 5,0-6,0, вода для инъекций - до 1 мл."},{"name":"Действующее вещество","value":"Дорзоламид+Тимолол","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["27144131:36090564"]}}},{"name":"Способ применения и дозы","value":"Препарат назначается по ОДНОЙ капле в конъюнктивальный мешок пораженного глаза (или обоих глаз) дважды в день.\u003Cbr\u003E\nВ случае если препарат назначается в качестве замены другого офтальмологического препарата для лечения глаукомы, последний следует отменить за день до начала терапии препаратом.\u003Cbr\u003E\nВ случае совместного использования с любыми другими глазными каплями, препараты следует применять с интервалом не менее 10 минут.\u003Cbr\u003E\nПри носослезной окклюзии (закрывании век) на 2 минуты после закапывания препарата происходит снижении его системной абсорбции, что может привести к усилению местного действия.\u003Cbr\u003E\nПрепарат представляет собой стерильный раствор и при неправильном использовании флакон может инфицироваться и стать причиной серьезных инфекционных поражений глаза и последующего снижения или потери зрения. Поэтому пациенты должны правильно пользоваться флаконом и НЕ КАСАТЬСЯ ПОВЕРХНОСТИ ТЛАЗА ИЛИ ВЕКА НАКОНЕЧНИКОМ ФЛАКОНА."},{"name":"Побочные действия","value":"Препарат в целом хорошо переносится. В клинических исследования побочных эффектов, свойственных исключительно этому комбинированному препарату, не наблюдалось. Побочные реакции ограничивались уже известными побочными эффектами дорзоламида и/или тимолола. В целом системные побочные эффекты были слабо выражены и не приводили к отмене препарата.\u003Cbr\u003E\nВ клинических исследованиях препарат назначался 1035 пациентам. Около 2,4 % пациентов препарат был отменен в связи с местными побочными реакциями со стороны глаза. Приблизительно у 1,2 % пациентов препарат был отменен из-за местных аллергических реакций. Среди наиболее частых побочных эффектов имели место чувство жжения или зуда в глазу, искажение вкуса, эрозии роговицы, инъекции конъюнктивы, нечеткость зрения, слезотечение.\u003Cbr\u003E\nВ пострегистрационный период наблюдения отмечались следующие нежелательные явления: одышка, дыхательная недостаточность, контактный дерматит, брадикардия, атриовентрикулярная блокада, отслойка хориоидальной оболочки глаза, тошнота, синдром Стивенса-Джонсона и токсический эпидермальный некролиз. Зарегистрированы случаи отека и необратимого разрушения роговицы у пациентов с хроническими дефектами роговицы и/или перенесших внутриглазную хирургическую операцию.\u003Cbr\u003E\nИзвестны следующие возможные побочные эффекты компонентов препарата:\u003Cbr\u003E\nДорзоламид:\u003Cbr\u003E\nГоловная боль, воспаление века, раздражение и шелушение века, астения/усталость, иридоциклит, сыпь, головокружение, парестезии, точечный кератит, транзиторная миопия (проходящая после отмены препарата), системные аллергические реакции, включающие ангиоотек, бронхоспазм, уртикарную сыпь и зуд, носовое кровотечение, раздражение глотки,сухость во рту.\u003Cbr\u003E\nТимолол (местное применение):\u003Cbr\u003E\nСо стороны глаз отмечались конъюнктивит, блефарит, кератит, снижение чувствительности роговицы, сухость; расстройства зрения, включающие изменения преломляющей способности глаза (в ряде случаев из-за отмены миотиков), диплопия, птоз; звон в ушах, аритмия, гипотензия, обморок, сердечно-сосудистые нарушения, нарушения ритма, остановка сердца, отеки, хромота, парестезии, феномен Рейно, снижение температуры рук и ног, бронхоспазм (преимущественно у пациентов с предшествующей бронхообструктивной патологией), кашель, головная боль, астения, усталость, боль в груди, алопеция, псориазоподобные высыпания или обострение псориаза; признаки и симптомы аллергической реакции, включающие анафилаксию, ангиоотек, уртикарную сыпь, локальные или генерализованные высыпания; головокружение; депрессия, бессонница, ночные кошмары, снижение памяти, нарастание симптомов миастении, диарея, диспепсия, сухость во рту, боль в животе, снижение либидо, болезнь Пейрони, сексуальная дисфункция, системная красная волчанка, миалгия.\u003Cbr\u003E\nТимолол (системное применение):\u003Cbr\u003E\nБоль в конечностях, снижение толерантности к физическим нагрузкам, атриовентрикулярная блокада II и III степени, синоаурикулярная блокада, отек легких, ухудшение артериальной недостаточности, ухудшение стенокардии, вазодилатация, рвота, гипергликемия, гипогликемия, зуд кожи, повышенное потоотделение, эксфолиативный дерматит, артралгия, головокружение, слабость, снижение концентрации внимания, повышенная сонливость, нетромбоцитопеническая пурпура, хрипы, импотенция, нарушения мочеиспускания.\u003Cbr\u003E\nПри системном применении тимолола малеата клинически значимые изменения стандартных лабораторных показателей отмечались крайне редко. Описаны легкое повышение остаточного азота, калия, мочевой кислоты и триглицеридов плазмы крови; легкое снижение гемоглобина, гематокрита, холестерина липопротеинов высокой плотности (ХС ЛПВП), однако указанные изменения не прогрессировали и клинически не проявлялись.\u003Cbr\u003E\nПрименение бета-адреноблокаторов может вызвать обострение псевдопаралитической миастении."},{"name":"Фармакологическое действие","value":"Препарат содержит два активных компонента: дорзоламид и тимолол, каждый из которых уменьшает повышенное внутриглазное давление за счет снижения секреции внутриглазной жидкости. Совместное действие этих веществ в составе комбинированного препарата приводит к более выраженному снижению внутриглазного давления.\u003Cbr\u003E\nДорзоламид является селективным ингибитором карбоангидразы II типа. Ингибирование карбоангидразы цилиарного тела приводит к снижению секреции внутриглазной жидкости, предположительно за счет уменьшения образования гидрокарбонат-ионов, что в свою очередь приводит к замедлению транспорта натрия и жидкости.\u003Cbr\u003E\nТимолол является неселективным бета-адреноблокатором. Хотя точный механизм действия тимолола малеата в снижении внутриглазного давления до сих пор не установлен, ряд исследований показали преимущественное снижение образования внутриглазной жидкости, а также незначительное усиление ее оттока."},{"name":"Фармакологическая группа","value":"противоглаукомное средство комбинированное (карбоангидразы ингибитор + бета- адреноблокатор)"},{"name":"Форма выпуска","value":"капли"},{"name":"Способ применения/введения","value":"наружный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["35947170:36763741"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"В защищенном от света месте при температуре не выше 25 °C.\u003Cbr\u003E\nХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Данные по случайной или преднамеренной передозировке препарата отсутствуют.\u003Cbr\u003E\nОписаны случаи неумышленной передозировки глазных капель тимолола с развитием системных эффектов передозировки бета-адреноблокаторов системного использования: головокружение, головная боль, одышка, брадикардия, бронхоспазм, остановка сердца. Наиболее ожидаемыми симптомами передозировки дорзоламида являются нарушение электролитного баланса, развитие ацидоза, возможные побочные эффекты со стороны центральной нервной системы.\u003Cbr\u003E\nЛечение передозировки симптоматическое и поддерживающее. Следует контролировать уровень электролитов (прежде всего калия) и pH плазмы крови. Тимолол не выводится при помощи диализа."},{"name":"Применение при беременности и кормлении грудью","value":"Не следует принимать препарат в период беременности и грудного вскармливания.\u003Cbr\u003E\nДорзоламид:\u003Cbr\u003E\nИнформации о применении дорзоламида у беременных женщин недостаточно. Неизвестно, проникает ли дорзоламид в грудное молоко кормящих женщин.\u003Cbr\u003E\nВ исследованиях на крысах выявлено тератогенное действие дорзоламида в дозах, токсичных для беременных самок. У детенышей лактирующих самок крыс, получавших дорзоламид, обнаружено уменьшение прироста массы тела.\u003Cbr\u003E\nТимолол:\u003Cbr\u003E\nИнформации о применении тимолола у беременных женщин недостаточно. Тимолол не следует принимать во время беременности, кроме случаев, когда применение тимолола является жизненно необходимым.\u003Cbr\u003E\nВ эпидемиологических исследованиях не обнаружено влияния пероральных бета-адреноблокаторов на развитие врожденных пороков, но выявлен риск задержки внутриутробного роста. Кроме того, у новорожденных были обнаружены признаки и симптомы блокады бета-адренорецепторов (брадикардия, гипотензия, дыхательная недостаточность и гипогликемия) в случае, когда бета-адреноблокаторы применялись до родов. Если препарат применялся до родов, следует тщательно наблюдать за состоянием новорожденных в первые дни жизни.\u003Cbr\u003E\nБета-адреноблокаторы проникают в грудное молоко. Лечащий врач должен принимать решение о необходимости прекращения грудного вскармливания или прекращения приема препарата, учитывая потенциальные серьезные побочные эффекты в отношении ребенка, находящегося на грудном вскармливании, и пользу препарата для матери."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"При использовании препарата возможно развитие побочных эффектов (см. Побочное действие), которые у некоторых пациентов могут затруднять управление автомобилем или работу со сложными механизмами."},{"name":"Особые указания","value":"При появлении первых признаков или симптомов сердечной недостаточности использование препарата следует прекратить.\u003Cbr\u003E\nИспользование контактных линз:\u003Cbr\u003E\nВ состав препарата входит консервант бензалкония хлорид, который может быть причиной возникновения раздражения глаза. Перед применением препарата линзы необходимо снять и вновь надеть их не ранее, чем через 15 минут после закапывания препарата. Бензалкония хлорид способен обесцвечивать мягкие контактные линзы."},{"name":"Взаимодействие","value":"Специфических исследований взаимодействия препарата с другими лекарственными средствами не проводилось. Тем не менее, существует возможность усиления гипотензивного эффекта и/или выраженной брадикардии при совместном применении офтальмологического раствора тимолола и системных блокаторов кальциевых каналов, катехоламин-истощающих средств, бета-адреноблокаторов, антиаритмических средств (включая амиодарон), гликозидов наперстянки, парасимпатомиметиков, опиоидных анальгетиков и ингибиторов моноаминоксидазы (МАО).\u003Cbr\u003E\nПри совместном применении тимолола и ингибиторов изофермента CYP2D6 (например, хинидин или селективные ингибиторы обратного захвата серотонина) сообщалось о потенцированном эффекте системной блокады бета-адренорецепторов (например, снижение частоты сердечных сокращений, депрессия).\u003Cbr\u003E\nНесмотря на то, что входящий в состав препарата ингибитор карбоангидразы дорзоламид используется местно, он может проникать в системный кровоток. В клинических исследованиях офтальмологического раствора дорзоламида не было выявлено расстройств кислотно-основного равновесия. Тем не менее, эти расстройства известны при системном использовании ингибиторов карбоангидразы и в ряде случаев могут сказываться на взаимодействии с другими лекарственными средствами (например, токсичность, связанная с терапией салицилатами в больших дозах). Вследствие этого возможность подобных взаимодействий должна приниматься во внимание у пациентов, получающих препарат.\u003Cbr\u003E\nСистемные бета-адреноблокаторы могут усиливать гипогликемический эффект противодиабетических препаратов и гипертензию, являющуюся эффектом отмены клонидина (клофелина).\u003Cbr\u003E\nНесмотря на то, что при монотерапии препаратом эффект на зрачок минимален или отсутствует, существуют единичные описания развития мидриаза при совместном применении тимолола и адреналина.\u003Cbr\u003E\nСуществует вероятность усиления известных системных эффектов ингибирования карбоангидразы при комбинированном применении местных и системных ингибиторов карбоангидразы. Так как данные о применении подобной комбинации отсутствуют, совместное применение препарата и системных ингибиторов карбоангидразы не рекомендуется."},{"name":"Регистрационный номер","value":"ЛП-006683"},{"name":"Дата государственной регистрации","value":"11.01.2021"},{"name":"Владелец регистрационного удостоверения","value":"Московский эндокринный завод","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["34324371:35649313","7893318:16002634"]}}},{"name":"Изготовитель","value":"Московский эндокринный завод"},{"name":"Фасовщик","value":"Московский эндокринный завод"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Срок годности","value":"1 г."}]}},"fullSpecsGrouped":{"6515487407809839089":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"глаза"},{"name":"Назначение","value":"открытоугольная глаукома, офтальмогипертензия"},{"name":"Показания к применению","value":"Препарат применяется для лечения повышенного внутриглазного давления при открытоугольной глаукоме и псевдоэксфолиативиой глаукоме при недостаточной эффективности монотерапии или офтальмогипертензии при недостаточном ответе на лечение бета-адреноблокаторами."},{"name":"Противопоказания","value":"- Гиперреактивность дыхательных путей, бронхиальная астма, бронхиальная астма в анамнезе, тяжелая хроническая обструктивная болезнь легких;\u003Cbr\u003E\n- синусовая брадикардия, синдром слабости синусового узла, синоатриальная блокада, антриовентрикулярная блокада II-III степени без кардиостимулятора, выраженная сердечная недостаточность, кардиогенный шок;\u003Cbr\u003E\n- тяжелая почечная недостаточность (КК меньше 30 мл/мин) или гиперхлоремический ацидоз;\u003Cbr\u003E\n- дистрофические процессы в роговице;\u003Cbr\u003E\n- беременность и период кормления грудью;\u003Cbr\u003E\n- повышенная чувствительность к любому компоненту препарата;\u003Cbr\u003E\n- детский возраст до 18 лет (в связи с недостаточной изученностью эффективности и безопасности)."},{"name":"Состав","value":"1 мл раствора содержит: действующие вещества: дорзоламида гидрохлорид - 22,26 мг (в пересчете на дорзоламид основание - 20,00 мг), тимолола малеат - 6,83 мг (в пересчете на тимолол - 5,00 мг); вспомогательные вещества: бензалкония хлорид 50 % раствор - 0,15 мг (эквивалентный 0,075 мг бензалкония хлорида), маннитол - 16,00 мг, гиэтеллоза (гидроксиэтилцеллюлоза) - 4,75 мг, натрия цитрат - 2,94 мг, натрия гидроксида раствор 1 М - до pH 5,0-6,0, вода для инъекций - до 1 мл."},{"name":"Действующее вещество","value":"Дорзоламид+Тимолол"},{"name":"Способ применения и дозы","value":"Препарат назначается по ОДНОЙ капле в конъюнктивальный мешок пораженного глаза (или обоих глаз) дважды в день.\u003Cbr\u003E\nВ случае если препарат назначается в качестве замены другого офтальмологического препарата для лечения глаукомы, последний следует отменить за день до начала терапии препаратом.\u003Cbr\u003E\nВ случае совместного использования с любыми другими глазными каплями, препараты следует применять с интервалом не менее 10 минут.\u003Cbr\u003E\nПри носослезной окклюзии (закрывании век) на 2 минуты после закапывания препарата происходит снижении его системной абсорбции, что может привести к усилению местного действия.\u003Cbr\u003E\nПрепарат представляет собой стерильный раствор и при неправильном использовании флакон может инфицироваться и стать причиной серьезных инфекционных поражений глаза и последующего снижения или потери зрения. Поэтому пациенты должны правильно пользоваться флаконом и НЕ КАСАТЬСЯ ПОВЕРХНОСТИ ТЛАЗА ИЛИ ВЕКА НАКОНЕЧНИКОМ ФЛАКОНА."},{"name":"Побочные действия","value":"Препарат в целом хорошо переносится. В клинических исследования побочных эффектов, свойственных исключительно этому комбинированному препарату, не наблюдалось. Побочные реакции ограничивались уже известными побочными эффектами дорзоламида и/или тимолола. В целом системные побочные эффекты были слабо выражены и не приводили к отмене препарата.\u003Cbr\u003E\nВ клинических исследованиях препарат назначался 1035 пациентам. Около 2,4 % пациентов препарат был отменен в связи с местными побочными реакциями со стороны глаза. Приблизительно у 1,2 % пациентов препарат был отменен из-за местных аллергических реакций. Среди наиболее частых побочных эффектов имели место чувство жжения или зуда в глазу, искажение вкуса, эрозии роговицы, инъекции конъюнктивы, нечеткость зрения, слезотечение.\u003Cbr\u003E\nВ пострегистрационный период наблюдения отмечались следующие нежелательные явления: одышка, дыхательная недостаточность, контактный дерматит, брадикардия, атриовентрикулярная блокада, отслойка хориоидальной оболочки глаза, тошнота, синдром Стивенса-Джонсона и токсический эпидермальный некролиз. Зарегистрированы случаи отека и необратимого разрушения роговицы у пациентов с хроническими дефектами роговицы и/или перенесших внутриглазную хирургическую операцию.\u003Cbr\u003E\nИзвестны следующие возможные побочные эффекты компонентов препарата:\u003Cbr\u003E\nДорзоламид:\u003Cbr\u003E\nГоловная боль, воспаление века, раздражение и шелушение века, астения/усталость, иридоциклит, сыпь, головокружение, парестезии, точечный кератит, транзиторная миопия (проходящая после отмены препарата), системные аллергические реакции, включающие ангиоотек, бронхоспазм, уртикарную сыпь и зуд, носовое кровотечение, раздражение глотки,сухость во рту.\u003Cbr\u003E\nТимолол (местное применение):\u003Cbr\u003E\nСо стороны глаз отмечались конъюнктивит, блефарит, кератит, снижение чувствительности роговицы, сухость; расстройства зрения, включающие изменения преломляющей способности глаза (в ряде случаев из-за отмены миотиков), диплопия, птоз; звон в ушах, аритмия, гипотензия, обморок, сердечно-сосудистые нарушения, нарушения ритма, остановка сердца, отеки, хромота, парестезии, феномен Рейно, снижение температуры рук и ног, бронхоспазм (преимущественно у пациентов с предшествующей бронхообструктивной патологией), кашель, головная боль, астения, усталость, боль в груди, алопеция, псориазоподобные высыпания или обострение псориаза; признаки и симптомы аллергической реакции, включающие анафилаксию, ангиоотек, уртикарную сыпь, локальные или генерализованные высыпания; головокружение; депрессия, бессонница, ночные кошмары, снижение памяти, нарастание симптомов миастении, диарея, диспепсия, сухость во рту, боль в животе, снижение либидо, болезнь Пейрони, сексуальная дисфункция, системная красная волчанка, миалгия.\u003Cbr\u003E\nТимолол (системное применение):\u003Cbr\u003E\nБоль в конечностях, снижение толерантности к физическим нагрузкам, атриовентрикулярная блокада II и III степени, синоаурикулярная блокада, отек легких, ухудшение артериальной недостаточности, ухудшение стенокардии, вазодилатация, рвота, гипергликемия, гипогликемия, зуд кожи, повышенное потоотделение, эксфолиативный дерматит, артралгия, головокружение, слабость, снижение концентрации внимания, повышенная сонливость, нетромбоцитопеническая пурпура, хрипы, импотенция, нарушения мочеиспускания.\u003Cbr\u003E\nПри системном применении тимолола малеата клинически значимые изменения стандартных лабораторных показателей отмечались крайне редко. Описаны легкое повышение остаточного азота, калия, мочевой кислоты и триглицеридов плазмы крови; легкое снижение гемоглобина, гематокрита, холестерина липопротеинов высокой плотности (ХС ЛПВП), однако указанные изменения не прогрессировали и клинически не проявлялись.\u003Cbr\u003E\nПрименение бета-адреноблокаторов может вызвать обострение псевдопаралитической миастении."},{"name":"Фармакологическое действие","value":"Препарат содержит два активных компонента: дорзоламид и тимолол, каждый из которых уменьшает повышенное внутриглазное давление за счет снижения секреции внутриглазной жидкости. Совместное действие этих веществ в составе комбинированного препарата приводит к более выраженному снижению внутриглазного давления.\u003Cbr\u003E\nДорзоламид является селективным ингибитором карбоангидразы II типа. Ингибирование карбоангидразы цилиарного тела приводит к снижению секреции внутриглазной жидкости, предположительно за счет уменьшения образования гидрокарбонат-ионов, что в свою очередь приводит к замедлению транспорта натрия и жидкости.\u003Cbr\u003E\nТимолол является неселективным бета-адреноблокатором. Хотя точный механизм действия тимолола малеата в снижении внутриглазного давления до сих пор не установлен, ряд исследований показали преимущественное снижение образования внутриглазной жидкости, а также незначительное усиление ее оттока."},{"name":"Фармакологическая группа","value":"противоглаукомное средство комбинированное (карбоангидразы ингибитор + бета- адреноблокатор)"},{"name":"Форма выпуска","value":"капли"},{"name":"Способ применения/введения","value":"наружный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"В защищенном от света месте при температуре не выше 25 °C.\u003Cbr\u003E\nХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Данные по случайной или преднамеренной передозировке препарата отсутствуют.\u003Cbr\u003E\nОписаны случаи неумышленной передозировки глазных капель тимолола с развитием системных эффектов передозировки бета-адреноблокаторов системного использования: головокружение, головная боль, одышка, брадикардия, бронхоспазм, остановка сердца. Наиболее ожидаемыми симптомами передозировки дорзоламида являются нарушение электролитного баланса, развитие ацидоза, возможные побочные эффекты со стороны центральной нервной системы.\u003Cbr\u003E\nЛечение передозировки симптоматическое и поддерживающее. Следует контролировать уровень электролитов (прежде всего калия) и pH плазмы крови. Тимолол не выводится при помощи диализа."},{"name":"Применение при беременности и кормлении грудью","value":"Не следует принимать препарат в период беременности и грудного вскармливания.\u003Cbr\u003E\nДорзоламид:\u003Cbr\u003E\nИнформации о применении дорзоламида у беременных женщин недостаточно. Неизвестно, проникает ли дорзоламид в грудное молоко кормящих женщин.\u003Cbr\u003E\nВ исследованиях на крысах выявлено тератогенное действие дорзоламида в дозах, токсичных для беременных самок. У детенышей лактирующих самок крыс, получавших дорзоламид, обнаружено уменьшение прироста массы тела.\u003Cbr\u003E\nТимолол:\u003Cbr\u003E\nИнформации о применении тимолола у беременных женщин недостаточно. Тимолол не следует принимать во время беременности, кроме случаев, когда применение тимолола является жизненно необходимым.\u003Cbr\u003E\nВ эпидемиологических исследованиях не обнаружено влияния пероральных бета-адреноблокаторов на развитие врожденных пороков, но выявлен риск задержки внутриутробного роста. Кроме того, у новорожденных были обнаружены признаки и симптомы блокады бета-адренорецепторов (брадикардия, гипотензия, дыхательная недостаточность и гипогликемия) в случае, когда бета-адреноблокаторы применялись до родов. Если препарат применялся до родов, следует тщательно наблюдать за состоянием новорожденных в первые дни жизни.\u003Cbr\u003E\nБета-адреноблокаторы проникают в грудное молоко. Лечащий врач должен принимать решение о необходимости прекращения грудного вскармливания или прекращения приема препарата, учитывая потенциальные серьезные побочные эффекты в отношении ребенка, находящегося на грудном вскармливании, и пользу препарата для матери."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"При использовании препарата возможно развитие побочных эффектов (см. Побочное действие), которые у некоторых пациентов могут затруднять управление автомобилем или работу со сложными механизмами."},{"name":"Особые указания","value":"При появлении первых признаков или симптомов сердечной недостаточности использование препарата следует прекратить.\u003Cbr\u003E\nИспользование контактных линз:\u003Cbr\u003E\nВ состав препарата входит консервант бензалкония хлорид, который может быть причиной возникновения раздражения глаза. Перед применением препарата линзы необходимо снять и вновь надеть их не ранее, чем через 15 минут после закапывания препарата. Бензалкония хлорид способен обесцвечивать мягкие контактные линзы."},{"name":"Взаимодействие","value":"Специфических исследований взаимодействия препарата с другими лекарственными средствами не проводилось. Тем не менее, существует возможность усиления гипотензивного эффекта и/или выраженной брадикардии при совместном применении офтальмологического раствора тимолола и системных блокаторов кальциевых каналов, катехоламин-истощающих средств, бета-адреноблокаторов, антиаритмических средств (включая амиодарон), гликозидов наперстянки, парасимпатомиметиков, опиоидных анальгетиков и ингибиторов моноаминоксидазы (МАО).\u003Cbr\u003E\nПри совместном применении тимолола и ингибиторов изофермента CYP2D6 (например, хинидин или селективные ингибиторы обратного захвата серотонина) сообщалось о потенцированном эффекте системной блокады бета-адренорецепторов (например, снижение частоты сердечных сокращений, депрессия).\u003Cbr\u003E\nНесмотря на то, что входящий в состав препарата ингибитор карбоангидразы дорзоламид используется местно, он может проникать в системный кровоток. В клинических исследованиях офтальмологического раствора дорзоламида не было выявлено расстройств кислотно-основного равновесия. Тем не менее, эти расстройства известны при системном использовании ингибиторов карбоангидразы и в ряде случаев могут сказываться на взаимодействии с другими лекарственными средствами (например, токсичность, связанная с терапией салицилатами в больших дозах). Вследствие этого возможность подобных взаимодействий должна приниматься во внимание у пациентов, получающих препарат.\u003Cbr\u003E\nСистемные бета-адреноблокаторы могут усиливать гипогликемический эффект противодиабетических препаратов и гипертензию, являющуюся эффектом отмены клонидина (клофелина).\u003Cbr\u003E\nНесмотря на то, что при монотерапии препаратом эффект на зрачок минимален или отсутствует, существуют единичные описания развития мидриаза при совместном применении тимолола и адреналина.\u003Cbr\u003E\nСуществует вероятность усиления известных системных эффектов ингибирования карбоангидразы при комбинированном применении местных и системных ингибиторов карбоангидразы. Так как данные о применении подобной комбинации отсутствуют, совместное применение препарата и системных ингибиторов карбоангидразы не рекомендуется."},{"name":"Регистрационный номер","value":"ЛП-006683"},{"name":"Дата государственной регистрации","value":"11.01.2021"},{"name":"Владелец регистрационного удостоверения","value":"Московский эндокринный завод"},{"name":"Изготовитель","value":"Московский эндокринный завод"},{"name":"Фасовщик","value":"Московский эндокринный завод"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Срок годности","value":"1 г."}]}],"transitionId":"tr_16438551248183632979"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

Где купить

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Все хиты10 — 16 июня
Акция

523 ₽

Скидка: 21%
–21 %
Вместо:663 ₽
  • 11-13 июня, самовывоз • 0 ₽
POLZAru
Рейтинг 4.9 из 5
38Котзывов
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    на основе 12 оценок
    Цена 524 ₽
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  • Моксиофтан гл. капли, 0,5%, 5 мл
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    Моксиофтан гл. капли, 0,5%, 5 мл

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 211 ₽
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  • Бетоптик С гл. капли фл., 0,25%, 5 мл, 1 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-se52q1vlqka/toggleWishlist":{"skuId":"228018718","productId":1778174352,"offerId":"PJl4ilyFeV8l26LFDCiLxg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQw6XC1tq06MmKARIxCi9Db21wZXRpdGl2ZUFuYWxvZ3NfTWFya2V0TW9kZWxDYXJkX0Zyb250U25pcHBldDIVCJCT888GEJ6U3WwYzqvHESDc3MEH","sign":"VLDuynFt2ZnsolcTKpNZv2kYzr+9fVuiT9RH3iZtLwg="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-se52q1vlqka/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Бетоптик С гл. капли фл., 0,25%, 5 мл, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 592 ₽
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  • Дорзотимол гл. капли, 20 мг/мл + 5 мг/мл, 5 мл
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    Дорзотимол гл. капли, 20 мг/мл + 5 мг/мл, 5 мл

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 742 ₽
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  • Дуопрост гл. капли, 2.5 мл
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    Дуопрост гл. капли, 2.5 мл

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 1 012 ₽
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  • Глаупрост гл. капли, 0.005%, 2.5 мл, 1 шт.
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    Глаупрост гл. капли, 0.005%, 2.5 мл, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 851 ₽
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  • Ксалаком гл. капли, 2.5 мл, 1 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-6phhjkzesf3/toggleWishlist":{"skuId":"265345928","productId":1778174606,"offerId":"oHnrBku1gr9ggyvixrdMaQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQw6XC1tq06MmKARIxCi9Db21wZXRpdGl2ZUFuYWxvZ3NfTWFya2V0TW9kZWxDYXJkX0Zyb250U25pcHBldDIVCI6V888GEIi3w34Yu5OMBiDc3MEH","sign":"vZQgg6NIaP/wS4Ri/lXeYl1TTLYItozfphkBiHN6C/g="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-6phhjkzesf3/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Ксалаком гл. капли, 2.5 мл, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 1 169 ₽
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  • Эксинта гл. капли, 0.007%, 5 мл, 1 шт.
    –1 %
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    Эксинта гл. капли, 0.007%, 5 мл, 1 шт.

    Рейтинг товара: 4.8 из 5
    на основе 9 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 328 ₽ вместо 331
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  • Неосинефрин-Пос гл. капли, 10%, 10 мл
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    Неосинефрин-Пос гл. капли, 10%, 10 мл

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 355 ₽
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Инструкция

Показания к применению

Препарат применяется для лечения повышенного внутриглазного давления при открытоугольной глаукоме и псевдоэксфолиативиой глаукоме при недостаточной эффективности монотерапии или офтальмогипертензии при недостаточном ответе на лечение бета-адреноблокаторами.

Противопоказания

- Гиперреактивность дыхательных путей, бронхиальная астма, бронхиальная астма в анамнезе, тяжелая хроническая обструктивная болезнь легких;
- синусовая брадикардия, синдром слабости синусового узла, синоатриальная блокада, антриовентрикулярная блокада II-III степени без кардиостимулятора, выраженная сердечная недостаточность, кардиогенный шок;
- тяжелая почечная недостаточность (КК меньше 30 мл/мин) или гиперхлоремический ацидоз;
- дистрофические процессы в роговице;
- беременность и период кормления грудью;
- повышенная чувствительность к любому компоненту препарата;
- детский возраст до 18 лет (в связи с недостаточной изученностью эффективности и безопасности).

Способ применения и дозы

Препарат назначается по ОДНОЙ капле в конъюнктивальный мешок пораженного глаза (или обоих глаз) дважды в день.
В случае если препарат назначается в качестве замены другого офтальмологического препарата для лечения глаукомы, последний следует отменить за день до начала терапии препаратом.
В случае совместного использования с любыми другими глазными каплями, препараты следует применять с интервалом не менее 10 минут.
При носослезной окклюзии (закрывании век) на 2 минуты после закапывания препарата происходит снижении его системной абсорбции, что может привести к усилению местного действия.
Препарат представляет собой стерильный раствор и при неправильном использовании флакон может инфицироваться и стать причиной серьезных инфекционных поражений глаза и последующего снижения или потери зрения. Поэтому пациенты должны правильно пользоваться флаконом и НЕ КАСАТЬСЯ ПОВЕРХНОСТИ ТЛАЗА ИЛИ ВЕКА НАКОНЕЧНИКОМ ФЛАКОНА.
Полная инструкция
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Глауламид гл. капли
Глауламид гл. капли, 20 мг/мл + 5 мг/мл, 5 мл
5.0
(1)
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Инструкция

523 ₽

Скидка: 21%
–21 %
Вместо:663 ₽
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5.0
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