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Описание

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Верапамил таб. п/о плен. пролонг., 240 мг, 20 шт.

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У продавца: 
нет • На Маркете: 4.4
(17)
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Коротко о товаре

Артикул Маркета
3123150479
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
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Гипертонический криз.\u003Cbr\u003EГипертрофическая кардиомиопатия."},{"name":"Противопоказания","value":"Повышенная чувствительность к компонентам препарата, выраженная брадикардия, кардиогенный шок, синоатриальная блокада, атриовентрикулярная блокада II и III степени, синдром слабости синусового узла (синдром брадикардии-тахикардии), синоатриальная блокада, выраженная артериальная гипотензия, синдром Вольфа-Паркинсона-Уайта, острая фаза осложненного инфаркта миокарда (с явлениями брадикардии, выраженной артериальной гипотензией, левожелудочковой недостаточностью), возраст до 18 лет (эффективность и безопасность не установлены), беременность и период лактации. С осторожностью:\u003Cbr\u003EАтриовентрикулярная блокада I степени, хроническая сердечная недостаточность, артериальная гипотензия (систолическое артериальное давление менее 90ммрт.ст.), мерцание/трепетание предсердий с синдромом Вольфа-Паркинсона-Уайта (риск возникновения желудочковой тахикардии), нарушение функции печени.\u003Cbr\u003E"},{"name":"Состав","value":"Действующее вещество: верапамила гидрохлорид – 240 мг\u003Cbr\u003EВспомогательные вещества: кальция фосфат двузамещенный, крахмал, бутилгидроксианизол, тальк очищенный, магния стеарат, желатин, метилпарабен, гидроксипропилметилцеллюлоза, титана диоксид, индиго кармин.\u003Cbr/\u003E"},{"name":"Действующее вещество","value":"Верапамил","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["27144131:28708402"]}}},{"name":"Способ применения и дозы","value":"Индивидуальный. Внутрь взрослым - в начальной дозе 40-80 мг 3 раза/сут. Для лекарственных форм пролонгированного действия разовую дозу следует увеличивать, а частоту приема уменьшать. Детям в возрасте 6-14 лет - 80-360 мг/сут, до 6 лет - 40-60 мг/сут; частота приема - 3-4 раза/сут.\u003Cbr\u003EПри необходимости верапамил можно вводить в/в струйно (медленно, под контролем АД, ЧСС и ЭКГ). Разовая доза для взрослых составляет 5-10 мг, при отсутствии эффекта через 20 мин возможно повторное введение в той же дозе. Разовая доза для детей в возрасте 6-14 лет составляет 2.5-3.5 мг, 1-5 лет - 2-3 мг, до 1 года - 0.75-2 мг. Для пациентов с выраженными нарушениями функции печени суточная доза верапамила не должна превышать 120 мг.\u003Cbr\u003EМаксимальная суточная доза для взрослых при приеме внутрь составляет 480 мг."},{"name":"Побочные действия","value":"Со стороны сердечно-сосудистой системы: брадикардия (менее 50 уд./мин), выраженное снижение АД, развитие или усугубление сердечной недостаточности, тахикардия; редко - стенокардия, вплоть до развития инфаркта миокарда (особенно у больных с тяжелым обструктивным поражением коронарных артерий), аритмия (в т.ч. мерцание и трепетание желудочков); при быстром в/в введении - AV-блокада III степени, асистолия, коллапс.\u003Cbr\u003EСо стороны ЦНС и периферической нервной системы: головокружение, головная боль, обморок, тревожность, заторможенность, повышенная утомляемость, астения, сонливость, депрессия, экстрапирамидные нарушения (атаксия, маскообразное лицо, шаркающая походка, тугоподвижность рук или ног, дрожание кистей и пальцев рук, затруднение глотания).\u003Cbr\u003EСо стороны пищеварительной системы: тошнота, запор (редко - диарея), гиперплазия десен (кровоточивость, болезненность, отечность), повышение аппетита, повышение активности печеночных трансаминаз и ЩФ.\u003Cbr\u003EАллергические реакции: кожный зуд, кожная сыпь, гиперемия кожи лица, многоформная экссудативная эритема (в т.ч. синдром Стивенса-Джонсона).\u003Cbr\u003EПрочие: увеличение массы тела, очень редко - агранулоцитоз, гинекомастия, гиперпролактинемия, галакторея, артрит, транзиторная потеря зрения на фоне максимальной концентрации в плазме (при в/в введении), отек легких, бессимптомная тромбоцитопения, периферические отеки."},{"name":"Фармакологическое действие","value":"Селективный блокатор кальциевых каналов I класса, производное дифенилалкиламина. Оказывает антиангинальное, антиаритмическое и антигипертензивное действие.\u003Cbr\u003EАнтиангинальный эффект связан как с прямым действием на миокард, так и с влиянием на периферическую гемодинамику (снижает тонус периферических артерий, ОПСС). Блокада поступления кальция в клетку приводит к уменьшению трансформации заключенной в макроэргических связях АТФ энергии в механическую работу, снижению сократимости миокарда. Уменьшает потребность миокарда в кислороде, оказывает вазодилатирующее, отрицательное ино- и хронотропное действие. Увеличивает период диастолического расслабления левого желудочка, уменьшает тонус стенки миокарда.\u003Cbr\u003EУменьшением ОПСС может быть также обусловлен антигипертензивный эффект верапамила.\u003Cbr\u003EВерапамил существенно снижает AV-проводимость, удлиняет период рефрактерности и подавляет автоматизм синусового узла. Оказывает антиаритмическое действие при наджелудочковых аритмиях."},{"name":"Фармакологическая группа","value":"блокатор \"медленных\" кальциевых каналов"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"Хранить в сухом месте, при температуре не выше 25°С. Препарат следует хранить в местах, недоступных для детей. Срок годности - 3 года."},{"name":"Передозировка","value":"Симптомы: большие дозы (прием до 6 г препарата) могут вызывать глубокую потерю сознания, артериальную гипертензию, синусовую брадикардию, переходящую в аAV-блокаду, иногда асистолию.\u003Cbr\u003EЛечение: при возникновении артериальной гилотензии и/или полной AV-блокады – в/в введение жидкости, допамина, кальция глюконата, изопротеренола или норадреналина. Лечение симптоматическое и зависит от клинической картины передозировки. Гемодиализ не эффективен."},{"name":"Применение при беременности и кормлении грудью","value":"Противопоказано."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"После приема верапамила возможны индивидуальные реакции (сонливость, головокружение), влияющие на способность пациента выполнять работу, требующую высокой концентрации внимания и скорости психомоторных реакций."},{"name":"Особые указания","value":"C осторожностью следует применять при AV-блокаде I степени, брадикардии, тяжелом стенозе устья аорты, хронической сердечной недостаточности, при легкой или умеренной артериальной гипотензии, в острой фазе инфаркте миокарда, обструктивной гипертрофической кардиомиопатии, при печеночной и/или почечной недостаточности, у пациентов пожилого возраста, у детей и подростков в возрасте до 18 лет (эффективность и безопасность применения не исследованы).\u003Cbr\u003EПри необходимости возможна комбинированная терапия стенокардии и артериальной гипертензии верапамилом и бета-адреноблокаторами. Однако следует избегать в/в введения бета-адреноблокаторов на фоне применения верапамила."},{"name":"Взаимодействие","value":"При одновременном применении с антигипертензивными препаратами (вазодилататорами, тиазидными диуретиками, ингибиторами АПФ) происходит взаимное усиление антигипертензивного действия.\u003Cbr\u003EПри одновременном применении с бета-адреноблокаторами, антиаритмическими средствами, средствами для ингаляционного наркоза повышается риск развития брадикардии, AV-блокады, выраженной артериальной гипотензии, сердечной недостаточности, в связи с взаимным усилением угнетающего влияния на автоматизм синоатриального узла и AV-проводимость, сократимость и проводимость миокарда.\u003Cbr\u003EПри парентеральном введении верапамила пациентам, недавно получавшим бета-адреноблокаторы, существует риск развития артериальной гипотензии и асистолии.\u003Cbr\u003EПри одновременном применении с нитратами усиливается антиангинальное действие верапамила.\u003Cbr\u003EПри одновременном применении с алискиреном увеличивается его концентрация в плазме и повышается риск развития побочных эффектов.\u003Cbr\u003EПри одновременном применении с амиодароном усиливается отрицательное инотропное действие, брадикардия, нарушение проводимости, AV-блокада.\u003Cbr\u003EПоскольку верапамил ингибирует изофермент CYP3A4, который участвует в метаболизме аторвастатина, ловастатина и симвастатина, теоретически возможны проявления лекарственного взаимодействия, обусловленные повышением концентраций статинов в плазме крови. Описаны случаи развития рабдомиолиза.\u003Cbr\u003EПри одновременном применении с ацетилсалициловой кислотой описаны случаи увеличения времени кровотечения вследствие аддитивного антиагрегантного действия.\u003Cbr\u003EПри одновременном применении с буспироном концентрация буспирона в плазме крови повышается, усиливаются его терапевтические и побочные эффекты.\u003Cbr\u003EПри одновременном введении верапамила и дантролена (в/в) в экспериментальных исследованиях у животных наблюдалась желудочковая фибрилляция с летальным исходом. Данная комбинация является потенциально опасной.\u003Cbr\u003EПри одновременном применении с дигоксином описаны случаи повышения концентрации дигитоксина в плазме крови.\u003Cbr\u003EПри одновременном применении с дигоксином повышается концентрация дигоксина в плазме крови.\u003Cbr\u003EПри одновременном применении с дизопирамидом возможны тяжелая артериальная гипотензия и коллапс, особенно у пациентов с кардиомиопатией или декомпенсированной сердечной недостаточностью. Риск развития тяжелых проявлений лекарственного взаимодействия связан, по-видимому, с усилением отрицательного инотропного действия.\u003Cbr\u003EПри одновременном применении с диклофенаком уменьшается концентрация верапамила в плазме крови; с доксорубицином - увеличивается концентрация доксорубицина в плазме крови и повышается его эффективность.\u003Cbr\u003EПри одновременном применении с имипрамином повышается концентрация имипрамина в плазме крови и возникает риск развития нежелательных изменений на ЭКГ. Верапамил повышает биодоступность имипрамина за счет уменьшения его клиренса. Изменения на ЭКГ обусловлены повышением концентрации имипрамина в плазме крови и аддитивным угнетающим действием верапамила и имипрамина на AV-проводимость.\u003Cbr\u003EПри одновременном применении с карбамазепином усиливается действие карбамазепина и повышается риск развития побочных эффектов со стороны ЦНС вследствие ингибирования метаболизма карбамазепина в печени под влиянием верапамила.\u003Cbr\u003EПри одновременном применении с клонидином описаны случаи остановки сердца у пациентов с артериальной гипертензией.\u003Cbr\u003EПовышает плазменную концентрацию колхицина (субстрат изофермента CYP3A и P-гликопротеина).\u003Cbr\u003EПри одновременном применении с лития карбонатом проявления лекарственного взаимодействия неоднозначны и непредсказуемы. Описаны случаи усиления эффектов лития и развития нейротоксичности, уменьшения концентрации лития в плазме крови, тяжелой брадикардии.\u003Cbr\u003EВазодилатирующее действие альфа-адреноблокаторов и блокаторов кальциевых каналов может быть аддитивным или синергичным. При одновременном применении теразозина или празозина и верапамила развитие выраженной артериальной гипотензии частично обусловлено фармакокинетическим взаимодействием: повышение Cmax и AUC теразозина и празозина.\u003Cbr\u003EПри одновременном применении рифампицин индуцирует активность ферментов печени, ускоряя метаболизм верапамила, что приводит к уменьшению его клинической эффективности.\u003Cbr\u003EПри одновременном применении с сертиндолом повышается риск развития желудочковых нарушений сердечного ритма, особенно желудочковой аритмии типа \"пируэт\".\u003Cbr\u003EПри одновременном применении повышается концентрация теофиллина в плазме крови.\u003Cbr\u003EПри одновременном применении с тубокурарина хлоридом, векурония хлоридом возможно усиление миорелаксирующего действия.\u003Cbr\u003EПри одновременном применении с фенитоином, фенобарбиталом возможно значительное уменьшение концентрации верапамила в плазме крови.\u003Cbr\u003EПри одновременном применении с флуоксетином усиливаются побочные эффекты верапамила вследствие замедления его метаболизма под влиянием флуоксетина.\u003Cbr\u003EПри одновременном применении снижается клиренс хинидина, повышается его концентрация в плазме крови и возрастает риск развития побочных эффектов. Наблюдались случаи развития артериальной гипотензии.\u003Cbr\u003EПри одновременном применении верапамил ингибирует метаболизм циклоспорина в печени, что приводит к уменьшению его выведения и повышению концентрации в плазме крови. Это сопровождается усилением иммунодепрессивного действия, отмечено уменьшение проявлений нефротоксичности.\u003Cbr\u003EПри одновременном применении с циметидином усиливаются эффекты верапамила.\u003Cbr\u003EПри одновременном применении с энфлураном возможно пролонгирование анестезии.\u003Cbr\u003EПри одновременном применении с этомидатом увеличивается продолжительность анестезии."},{"name":"Источник","value":"\u003Ca href=\"https://www.vidal.ru\" target=\"_blank\"\u003EСправочник лекарственных препаратов Видаль<\u002Fa\u003E"},{"name":"Регистрационный номер","value":"П N011991/03"},{"name":"Дата государственной регистрации","value":"04.12.2020"},{"name":"Владелец регистрационного удостоверения","value":"Алкалоид","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["34324371:35649313","7893318:16003172"]}}},{"name":"Изготовитель","value":"Алкалоид"},{"name":"Страна-производитель","value":"Республика Северная Македония"},{"name":"Название препарата","value":"Верапамил","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["17796364:17893141"]}}},{"name":"Срок годности","value":"60 мес."}]}},"fullSpecsGrouped":{"7483567810067797450":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"кровеносные сосуды, сердце"},{"name":"Назначение","value":"аритмия, артериальная гипертензия, нарушение ритма сердца, пароксизмальная наджелудочковая тахикардия, профилактика приступов стенокардии, стенокардия, экстрасистолия"},{"name":"Показания к применению","value":"Лечение и профилактика ИБС: хроническая стабильная стенокардия (стенокардия напряжения), нестабильная стенокардия, вазоспастическая стенокардия (стенокардия Принцметала/вариантная стенокардия).\u003Cbr\u003EЛечение и профилактика нарушений сердечного ритма: пароксизмальная наджелудочковая тахикардия, хроническая форма трепетания и мерцания предсердий (тахиаритмический вариант), наджелудочковая экстрасистолия.\u003Cbr\u003EАртериальная гипертензия. Гипертонический криз.\u003Cbr\u003EГипертрофическая кардиомиопатия."},{"name":"Противопоказания","value":"Повышенная чувствительность к компонентам препарата, выраженная брадикардия, кардиогенный шок, синоатриальная блокада, атриовентрикулярная блокада II и III степени, синдром слабости синусового узла (синдром брадикардии-тахикардии), синоатриальная блокада, выраженная артериальная гипотензия, синдром Вольфа-Паркинсона-Уайта, острая фаза осложненного инфаркта миокарда (с явлениями брадикардии, выраженной артериальной гипотензией, левожелудочковой недостаточностью), возраст до 18 лет (эффективность и безопасность не установлены), беременность и период лактации. С осторожностью:\u003Cbr\u003EАтриовентрикулярная блокада I степени, хроническая сердечная недостаточность, артериальная гипотензия (систолическое артериальное давление менее 90ммрт.ст.), мерцание/трепетание предсердий с синдромом Вольфа-Паркинсона-Уайта (риск возникновения желудочковой тахикардии), нарушение функции печени.\u003Cbr\u003E"},{"name":"Состав","value":"Действующее вещество: верапамила гидрохлорид – 240 мг\u003Cbr\u003EВспомогательные вещества: кальция фосфат двузамещенный, крахмал, бутилгидроксианизол, тальк очищенный, магния стеарат, желатин, метилпарабен, гидроксипропилметилцеллюлоза, титана диоксид, индиго кармин.\u003Cbr/\u003E"},{"name":"Действующее вещество","value":"Верапамил"},{"name":"Способ применения и дозы","value":"Индивидуальный. Внутрь взрослым - в начальной дозе 40-80 мг 3 раза/сут. Для лекарственных форм пролонгированного действия разовую дозу следует увеличивать, а частоту приема уменьшать. Детям в возрасте 6-14 лет - 80-360 мг/сут, до 6 лет - 40-60 мг/сут; частота приема - 3-4 раза/сут.\u003Cbr\u003EПри необходимости верапамил можно вводить в/в струйно (медленно, под контролем АД, ЧСС и ЭКГ). Разовая доза для взрослых составляет 5-10 мг, при отсутствии эффекта через 20 мин возможно повторное введение в той же дозе. Разовая доза для детей в возрасте 6-14 лет составляет 2.5-3.5 мг, 1-5 лет - 2-3 мг, до 1 года - 0.75-2 мг. Для пациентов с выраженными нарушениями функции печени суточная доза верапамила не должна превышать 120 мг.\u003Cbr\u003EМаксимальная суточная доза для взрослых при приеме внутрь составляет 480 мг."},{"name":"Побочные действия","value":"Со стороны сердечно-сосудистой системы: брадикардия (менее 50 уд./мин), выраженное снижение АД, развитие или усугубление сердечной недостаточности, тахикардия; редко - стенокардия, вплоть до развития инфаркта миокарда (особенно у больных с тяжелым обструктивным поражением коронарных артерий), аритмия (в т.ч. мерцание и трепетание желудочков); при быстром в/в введении - AV-блокада III степени, асистолия, коллапс.\u003Cbr\u003EСо стороны ЦНС и периферической нервной системы: головокружение, головная боль, обморок, тревожность, заторможенность, повышенная утомляемость, астения, сонливость, депрессия, экстрапирамидные нарушения (атаксия, маскообразное лицо, шаркающая походка, тугоподвижность рук или ног, дрожание кистей и пальцев рук, затруднение глотания).\u003Cbr\u003EСо стороны пищеварительной системы: тошнота, запор (редко - диарея), гиперплазия десен (кровоточивость, болезненность, отечность), повышение аппетита, повышение активности печеночных трансаминаз и ЩФ.\u003Cbr\u003EАллергические реакции: кожный зуд, кожная сыпь, гиперемия кожи лица, многоформная экссудативная эритема (в т.ч. синдром Стивенса-Джонсона).\u003Cbr\u003EПрочие: увеличение массы тела, очень редко - агранулоцитоз, гинекомастия, гиперпролактинемия, галакторея, артрит, транзиторная потеря зрения на фоне максимальной концентрации в плазме (при в/в введении), отек легких, бессимптомная тромбоцитопения, периферические отеки."},{"name":"Фармакологическое действие","value":"Селективный блокатор кальциевых каналов I класса, производное дифенилалкиламина. Оказывает антиангинальное, антиаритмическое и антигипертензивное действие.\u003Cbr\u003EАнтиангинальный эффект связан как с прямым действием на миокард, так и с влиянием на периферическую гемодинамику (снижает тонус периферических артерий, ОПСС). Блокада поступления кальция в клетку приводит к уменьшению трансформации заключенной в макроэргических связях АТФ энергии в механическую работу, снижению сократимости миокарда. Уменьшает потребность миокарда в кислороде, оказывает вазодилатирующее, отрицательное ино- и хронотропное действие. Увеличивает период диастолического расслабления левого желудочка, уменьшает тонус стенки миокарда.\u003Cbr\u003EУменьшением ОПСС может быть также обусловлен антигипертензивный эффект верапамила.\u003Cbr\u003EВерапамил существенно снижает AV-проводимость, удлиняет период рефрактерности и подавляет автоматизм синусового узла. Оказывает антиаритмическое действие при наджелудочковых аритмиях."},{"name":"Фармакологическая группа","value":"блокатор \"медленных\" кальциевых каналов"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Хранить в сухом месте, при температуре не выше 25°С. Препарат следует хранить в местах, недоступных для детей. Срок годности - 3 года."},{"name":"Передозировка","value":"Симптомы: большие дозы (прием до 6 г препарата) могут вызывать глубокую потерю сознания, артериальную гипертензию, синусовую брадикардию, переходящую в аAV-блокаду, иногда асистолию.\u003Cbr\u003EЛечение: при возникновении артериальной гилотензии и/или полной AV-блокады – в/в введение жидкости, допамина, кальция глюконата, изопротеренола или норадреналина. Лечение симптоматическое и зависит от клинической картины передозировки. Гемодиализ не эффективен."},{"name":"Применение при беременности и кормлении грудью","value":"Противопоказано."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"После приема верапамила возможны индивидуальные реакции (сонливость, головокружение), влияющие на способность пациента выполнять работу, требующую высокой концентрации внимания и скорости психомоторных реакций."},{"name":"Особые указания","value":"C осторожностью следует применять при AV-блокаде I степени, брадикардии, тяжелом стенозе устья аорты, хронической сердечной недостаточности, при легкой или умеренной артериальной гипотензии, в острой фазе инфаркте миокарда, обструктивной гипертрофической кардиомиопатии, при печеночной и/или почечной недостаточности, у пациентов пожилого возраста, у детей и подростков в возрасте до 18 лет (эффективность и безопасность применения не исследованы).\u003Cbr\u003EПри необходимости возможна комбинированная терапия стенокардии и артериальной гипертензии верапамилом и бета-адреноблокаторами. Однако следует избегать в/в введения бета-адреноблокаторов на фоне применения верапамила."},{"name":"Взаимодействие","value":"При одновременном применении с антигипертензивными препаратами (вазодилататорами, тиазидными диуретиками, ингибиторами АПФ) происходит взаимное усиление антигипертензивного действия.\u003Cbr\u003EПри одновременном применении с бета-адреноблокаторами, антиаритмическими средствами, средствами для ингаляционного наркоза повышается риск развития брадикардии, AV-блокады, выраженной артериальной гипотензии, сердечной недостаточности, в связи с взаимным усилением угнетающего влияния на автоматизм синоатриального узла и AV-проводимость, сократимость и проводимость миокарда.\u003Cbr\u003EПри парентеральном введении верапамила пациентам, недавно получавшим бета-адреноблокаторы, существует риск развития артериальной гипотензии и асистолии.\u003Cbr\u003EПри одновременном применении с нитратами усиливается антиангинальное действие верапамила.\u003Cbr\u003EПри одновременном применении с алискиреном увеличивается его концентрация в плазме и повышается риск развития побочных эффектов.\u003Cbr\u003EПри одновременном применении с амиодароном усиливается отрицательное инотропное действие, брадикардия, нарушение проводимости, AV-блокада.\u003Cbr\u003EПоскольку верапамил ингибирует изофермент CYP3A4, который участвует в метаболизме аторвастатина, ловастатина и симвастатина, теоретически возможны проявления лекарственного взаимодействия, обусловленные повышением концентраций статинов в плазме крови. Описаны случаи развития рабдомиолиза.\u003Cbr\u003EПри одновременном применении с ацетилсалициловой кислотой описаны случаи увеличения времени кровотечения вследствие аддитивного антиагрегантного действия.\u003Cbr\u003EПри одновременном применении с буспироном концентрация буспирона в плазме крови повышается, усиливаются его терапевтические и побочные эффекты.\u003Cbr\u003EПри одновременном введении верапамила и дантролена (в/в) в экспериментальных исследованиях у животных наблюдалась желудочковая фибрилляция с летальным исходом. Данная комбинация является потенциально опасной.\u003Cbr\u003EПри одновременном применении с дигоксином описаны случаи повышения концентрации дигитоксина в плазме крови.\u003Cbr\u003EПри одновременном применении с дигоксином повышается концентрация дигоксина в плазме крови.\u003Cbr\u003EПри одновременном применении с дизопирамидом возможны тяжелая артериальная гипотензия и коллапс, особенно у пациентов с кардиомиопатией или декомпенсированной сердечной недостаточностью. Риск развития тяжелых проявлений лекарственного взаимодействия связан, по-видимому, с усилением отрицательного инотропного действия.\u003Cbr\u003EПри одновременном применении с диклофенаком уменьшается концентрация верапамила в плазме крови; с доксорубицином - увеличивается концентрация доксорубицина в плазме крови и повышается его эффективность.\u003Cbr\u003EПри одновременном применении с имипрамином повышается концентрация имипрамина в плазме крови и возникает риск развития нежелательных изменений на ЭКГ. Верапамил повышает биодоступность имипрамина за счет уменьшения его клиренса. Изменения на ЭКГ обусловлены повышением концентрации имипрамина в плазме крови и аддитивным угнетающим действием верапамила и имипрамина на AV-проводимость.\u003Cbr\u003EПри одновременном применении с карбамазепином усиливается действие карбамазепина и повышается риск развития побочных эффектов со стороны ЦНС вследствие ингибирования метаболизма карбамазепина в печени под влиянием верапамила.\u003Cbr\u003EПри одновременном применении с клонидином описаны случаи остановки сердца у пациентов с артериальной гипертензией.\u003Cbr\u003EПовышает плазменную концентрацию колхицина (субстрат изофермента CYP3A и P-гликопротеина).\u003Cbr\u003EПри одновременном применении с лития карбонатом проявления лекарственного взаимодействия неоднозначны и непредсказуемы. Описаны случаи усиления эффектов лития и развития нейротоксичности, уменьшения концентрации лития в плазме крови, тяжелой брадикардии.\u003Cbr\u003EВазодилатирующее действие альфа-адреноблокаторов и блокаторов кальциевых каналов может быть аддитивным или синергичным. При одновременном применении теразозина или празозина и верапамила развитие выраженной артериальной гипотензии частично обусловлено фармакокинетическим взаимодействием: повышение Cmax и AUC теразозина и празозина.\u003Cbr\u003EПри одновременном применении рифампицин индуцирует активность ферментов печени, ускоряя метаболизм верапамила, что приводит к уменьшению его клинической эффективности.\u003Cbr\u003EПри одновременном применении с сертиндолом повышается риск развития желудочковых нарушений сердечного ритма, особенно желудочковой аритмии типа \"пируэт\".\u003Cbr\u003EПри одновременном применении повышается концентрация теофиллина в плазме крови.\u003Cbr\u003EПри одновременном применении с тубокурарина хлоридом, векурония хлоридом возможно усиление миорелаксирующего действия.\u003Cbr\u003EПри одновременном применении с фенитоином, фенобарбиталом возможно значительное уменьшение концентрации верапамила в плазме крови.\u003Cbr\u003EПри одновременном применении с флуоксетином усиливаются побочные эффекты верапамила вследствие замедления его метаболизма под влиянием флуоксетина.\u003Cbr\u003EПри одновременном применении снижается клиренс хинидина, повышается его концентрация в плазме крови и возрастает риск развития побочных эффектов. Наблюдались случаи развития артериальной гипотензии.\u003Cbr\u003EПри одновременном применении верапамил ингибирует метаболизм циклоспорина в печени, что приводит к уменьшению его выведения и повышению концентрации в плазме крови. Это сопровождается усилением иммунодепрессивного действия, отмечено уменьшение проявлений нефротоксичности.\u003Cbr\u003EПри одновременном применении с циметидином усиливаются эффекты верапамила.\u003Cbr\u003EПри одновременном применении с энфлураном возможно пролонгирование анестезии.\u003Cbr\u003EПри одновременном применении с этомидатом увеличивается продолжительность анестезии."},{"name":"Источник","value":"\u003Ca href=\"https://www.vidal.ru\" target=\"_blank\"\u003EСправочник лекарственных препаратов Видаль<\u002Fa\u003E"},{"name":"Регистрационный номер","value":"П N011991/03"},{"name":"Дата государственной регистрации","value":"04.12.2020"},{"name":"Владелец регистрационного удостоверения","value":"Алкалоид"},{"name":"Изготовитель","value":"Алкалоид"},{"name":"Страна-производитель","value":"Республика Северная Македония"},{"name":"Название препарата","value":"Верапамил"},{"name":"Срок годности","value":"60 мес."}]}],"transitionId":"tr_2411057004889808530"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

Где купить

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204 ₽

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ЕАПТЕКА
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Ещё может подойти

  • Верапамил таб. п/о плен., 40 мг, 30 шт.
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    Верапамил таб. п/о плен., 40 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 6 оценок
    Цена 55 ₽
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  • Дилтиазем таб. пролонг. действ., 90 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-cfkw9nk42zj/toggleWishlist":{"skuId":"228004172","productId":1778173668,"offerId":"WdbLOH6RaOswZVJAtyDaBw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQw8GWiJu2o5I7EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI5I3zzwYQzKLcbBjk4NAHINfcwQc=","sign":"0pNVZiKvyTA3E9oDpo8AxPFZIpERat8w2suuqMI89c8="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-cfkw9nk42zj/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Дилтиазем таб. пролонг. действ., 90 мг, 30 шт.

    Рейтинг товара: 4.8 из 5
    на основе 13 оценок
    Цена 279 ₽
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  • Изоптин СР таб. п/о плен. пролонг., 240 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-jgg4lprtfc/toggleWishlist":{"skuId":"101480525733","productId":647076117,"offerId":"WKiznXrskVgxP-FaI_3WiQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQw8GWiJu2o5I7EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIlbLGtAIQpd/XhfoCGNDE3gcg19zBBw==","sign":"WzPmZBd+CTQgYLvtUhTHd3RR/d684B38PwJaOA3cWfY="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-jgg4lprtfc/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Изоптин СР таб. п/о плен. пролонг., 240 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 519 ₽
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  • Амиодарон таб., 200 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-1trsbbr87y3/toggleWishlist":{"skuId":"662112004","productId":1780857907,"offerId":"nDzVxZDACWFaZO6NiGlTiA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQw8GWiJu2o5I7EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIs/iW0QYQhI7cuwIYhKmyCCDX3MEH","sign":"O9ZnWYKwm5Ss5ySzOqRKg6O7VUtf8SKklZcWZ9vkwGE="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-1trsbbr87y3/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Амиодарон таб., 200 мг, 30 шт.

    Рейтинг товара: 4 из 5
    на основе 1 оценка
    Цена 221 ₽
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  • Дигоксин таб., 250 мкг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-06pq4czdcsl/toggleWishlist":{"skuId":"228041370","productId":1778173704,"offerId":"j6PoleBX3PIUzeEkgXGCzg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQw8GWiJu2o5I7EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIiI7zzwYQmsXebBj+w9kHINfcwQc=","sign":"eMMZl/lu/iTkwoPd9N40Sw2pNsqh9GK3ln3sm1MvcYk="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-06pq4czdcsl/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Дигоксин таб., 250 мкг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 48 ₽
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  • Эринит таб., 10 мг, 50 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-qiihs0jr29/toggleWishlist":{"skuId":"227830585","productId":1778173651,"offerId":"P73ChIMNj32ilRrSDYOTXg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQw8GWiJu2o5I7EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI043zzwYQudbRbBjC4NAHINfcwQc=","sign":"MvzIO9vhaMRJgfcsSLiQh6DgIrlhLb7ig5JvG3JbVWs="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-qiihs0jr29/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Эринит таб., 10 мг, 50 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 139 ₽
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  • Кавинтон форте таб., 10 мг, 30 шт.
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    Кавинтон форте таб., 10 мг, 30 шт.

    Рейтинг товара: 4.7 из 5
    на основе 3 оценки
    Цена 196 ₽
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  • Триметазидин таб. п/о плен., 20 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-z6j1niqp72f/toggleWishlist":{"skuId":"634116303","productId":1401075509,"offerId":"sVxFNZ3lQnQvraxal23zJg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQw8GWiJu2o5I7EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIte6KnAUQz7GvrgIY1/HPBiDX3MEH","sign":"w7xNsVlYi93carOdssRtugLmxW/YRlWP/wWoUeXWfmQ="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-z6j1niqp72f/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Триметазидин таб. п/о плен., 20 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 12 оценок
    Цена 235 ₽
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  • Индапамид таб. пролонг. высвоб. п/о плен., 1.5 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-dkc2i5lf1b6/toggleWishlist":{"skuId":"101526382745","productId":1489410589,"offerId":"6_64D-haNb00vsw97dz69w","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQw8GWiJu2o5I7EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcInbSaxgUQmdHGm/oCGPKsgggg19zBBw==","sign":"o4xiGJmgHwqLoNVT4AfUCx0lqN0MGtwLb4AKK8NMvo8="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-dkc2i5lf1b6/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Индапамид таб. пролонг. высвоб. п/о плен., 1.5 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 142 ₽
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  • Эналаприл таб., 10 мг, 50 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-dcartjgmeau/toggleWishlist":{"skuId":"101875277953","productId":1784969488,"offerId":"qHHfl_F3UwgFTqeDiyp_Aw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQw8GWiJu2o5I7EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIkPKR0wYQgcH1wfsCGJe2+wUg19zBBw==","sign":"LBQenw4w2WQsU9NAQjx0Kb2YZ6nEq8EwuI1CTEN8Cag="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-dcartjgmeau/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Эналаприл таб., 10 мг, 50 шт.

    Рейтинг товара: 4.8 из 5
    на основе 55 оценок
    Цена 150 ₽
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Инструкция

Показания к применению

Лечение и профилактика ИБС: хроническая стабильная стенокардия (стенокардия напряжения), нестабильная стенокардия, вазоспастическая стенокардия (стенокардия Принцметала/вариантная стенокардия).
Лечение и профилактика нарушений сердечного ритма: пароксизмальная наджелудочковая тахикардия, хроническая форма трепетания и мерцания предсердий (тахиаритмический вариант), наджелудочковая экстрасистолия.
Артериальная гипертензия. Гипертонический криз.
Гипертрофическая кардиомиопатия.

Противопоказания

Повышенная чувствительность к компонентам препарата, выраженная брадикардия, кардиогенный шок, синоатриальная блокада, атриовентрикулярная блокада II и III степени, синдром слабости синусового узла (синдром брадикардии-тахикардии), синоатриальная блокада, выраженная артериальная гипотензия, синдром Вольфа-Паркинсона-Уайта, острая фаза осложненного инфаркта миокарда (с явлениями брадикардии, выраженной артериальной гипотензией, левожелудочковой недостаточностью), возраст до 18 лет (эффективность и безопасность не установлены), беременность и период лактации. С осторожностью:
Атриовентрикулярная блокада I степени, хроническая сердечная недостаточность, артериальная гипотензия (систолическое артериальное давление менее 90ммрт.ст.), мерцание/трепетание предсердий с синдромом Вольфа-Паркинсона-Уайта (риск возникновения желудочковой тахикардии), нарушение функции печени.

Способ применения и дозы

Индивидуальный. Внутрь взрослым - в начальной дозе 40-80 мг 3 раза/сут. Для лекарственных форм пролонгированного действия разовую дозу следует увеличивать, а частоту приема уменьшать. Детям в возрасте 6-14 лет - 80-360 мг/сут, до 6 лет - 40-60 мг/сут; частота приема - 3-4 раза/сут.
При необходимости верапамил можно вводить в/в струйно (медленно, под контролем АД, ЧСС и ЭКГ). Разовая доза для взрослых составляет 5-10 мг, при отсутствии эффекта через 20 мин возможно повторное введение в той же дозе. Разовая доза для детей в возрасте 6-14 лет составляет 2.5-3.5 мг, 1-5 лет - 2-3 мг, до 1 года - 0.75-2 мг. Для пациентов с выраженными нарушениями функции печени суточная доза верапамила не должна превышать 120 мг.
Максимальная суточная доза для взрослых при приеме внутрь составляет 480 мг.
Полная инструкция
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Верапамил таб. п/о плен. пролонг.
Верапамил таб. п/о плен. пролонг., 240 мг, 20 шт.
У продавца: 
нет • На Маркете: 4.4
(17)
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1 вопрос
Инструкция

204 ₽

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