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Зифлукорт таб., 0.1 мг, 20 шт.

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У продавца: 
нет • На Маркете: 4.8
(4)
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Коротко о товаре

Артикул Маркета
589876943
Тип препарата
Назначение
Действующее вещество
Форма выпуска
таблетки
Инструкция
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Вспомогательные вещества: целлюлоза микрокристаллическая тип 200- 189.9 мг, повидон К25 - 8 мг, кремния диоксид коллоидный - 1 мг, магния стеарат - 1 мг.\u003Cbr\u003E"},{"name":"Действующее вещество","value":"Флудрокортизон","transition":{"type":"catalog","params":{"categorySlug":"sistemnye-gormonalnye-preparaty","categoryId":"15756915","navnodeId":"72510","glfilters":["27144131:28708988"]}}},{"name":"Способ применения и дозы","value":"Устанавливают индивидуально, в зависимости от показаний, эффективности терапии, состояния пациента и его возраста. В процессе лечения при изменении клинической картины или во время стрессовых ситуаций, таких как хирургическая операция, травма или инфекция, может быть необходима коррекция дозы."},{"name":"Побочные действия","value":"Со стороны эндокринной системы: возможны угнетение продукции АКТГ, повышение уровня глюкозы в крови, нарушения менструального цикла.\u003Cbr\u003EСо стороны обмена веществ: возможны угнетение синтеза белка, замедление роста у детей, отеки.\u003Cbr\u003EСо стороны пищеварительной системы: возможны эрозивно-язвенные поражения ЖКТ.\u003Cbr\u003EПрочие: возможны кожная сыпь, повышение АД.\u003Cbr\u003EПри местном применении: возможны повышение внутриглазного давления, образование субкапсулярной катаракты.\u003Cbr\u003E\u003Cbr\u003E"},{"name":"Фармакологическое действие","value":"Кортикостероид с выраженной минералокортикоидной активностью и глюкокортикоидной активностью. Минералокортикоидное действие обусловлено связыванием с минералокортикоидными рецепторами в цитоплазме клеток-мишеней, в первую очередь в клетках собирательных трубочек почек. В результате происходит увеличение реабсорбции натрия, выведение калия и водорода, при этом наблюдается задержка воды. Повышается также реабсорбция натрия в потовых и слюнных железах, слизистой оболочке ЖКТ и через клеточные мембраны. Обладая глюкокортикоидной активностью, флудрокортизон подавляет функции лейкоцитов и тканевых макрофагов. Ограничивает миграцию лейкоцитов в область воспаления. Нарушает способность макрофагов к фагоцитозу, а также к образованию интерлейкина-1. Способствует стабилизации лизосомальных мембран, снижая тем самым концентрацию протеолитических ферментов в области воспаления. Уменьшает проницаемость капилляров, обусловленную высвобождением гистамина. Подавляет активность фибробластов и образование коллагена. Флудрокортизон ингибирует активность фосфолипазы А2, что приводит к подавлению синтеза простагландинов и лейкотриенов; подавляет высвобождение ЦОГ (главным образом ЦОГ-2), что также способствует уменьшению выработки простагландинов. Уменьшает число циркулирующих лимфоцитов (T- и B-клеток), моноцитов, эозинофилов и базофилов вследствие их перемещения из сосудистого русла в лимфоидную ткань; подавляет образование антител. Флудрокортизон подавляет высвобождение гипофизом АКТГ и бета-липотропина, но не снижает уровень циркулирующего бета-эндорфина; угнетает секрецию ТТГ и ФСГ. При непосредственной аппликации на сосуды вызывает вазоконстрикторный эффект. Стимулирует глюконеогенез, способствует захвату аминокислот печенью и почками и повышает активность ферментов глюконеогенеза. В печени флудрокортизон усиливает депонирование гликогена, стимулируя активность гликогенсинтетазы и синтез глюкозы из продуктов белкового обмена. Повышение содержания глюкозы в крови активизирует выделение инсулина. Подавляет захват глюкозы жировыми клетками, что приводит к активации липолиза. Однако вследствие увеличения секреции инсулина происходит стимуляция липогенеза, что приводит к накоплению жира. Оказывает катаболическое действие в лимфоидной и соединительной ткани, мышцах, жировой ткани, коже, костной ткани. В результате катаболического действия возможно подавление роста у детей. В высоких дозах флудрокортизон может повышать возбудимость тканей мозга и способствует понижению порога судорожной готовности. Стимулирует избыточную продукцию хлористоводородной кислоты и пепсина в желудке, что способствует развитию пептической язвы. По сравнению с гидрокортизоном, способность флудрокортизона задерживать ионы натрия в организме выражена в 250 раз сильнее, противовоспалительная активность - в 10 раз сильнее.\u003Cbr\u003E\u003Cbr\u003E"},{"name":"Фармакологическая группа","value":"минералокортикостероиды"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sistemnye-gormonalnye-preparaty","categoryId":"15756915","navnodeId":"72510","glfilters":["35947170:36763744"]}}},{"name":"Условия хранения","value":"В защищенном от света месте, при температуре не выше 25 град."},{"name":"Применение при беременности и кормлении грудью","value":"Применение при беременности или у женщин, планирующих беременность, возможно только в тех случаях, когда предполагаемая польза для матери превышает потенциальный риск для плода. При необходимости применения в период лактации следует решить вопрос о прекращении грудного вскармливания."},{"name":"Особые указания","value":"С осторожностью\u003Cbr\u003EПри язвенном колите, дивертикулезе кишечника, язвенной болезни желудка или двенадцатиперстной кишки, острой или латентной пептической язве, недавно созданных анастомозах кишечника, эзофагите, гастрите, операциях на ЖКТ в анамнезе, нарушениях функции печени, почечной недостаточности, артериальной гипертензии, остеопорозе, миастении, гипоальбуминемии и состояниях, предрасполагающих к ее возникновению, гиперлипидемии; при сахарном диабете (в т.ч. нарушении толерантности к углеводам), гипотиреозе, болезни Иценко-Кушинга, тиреотоксикозе, ожирении (III-IV ст.), остром психозе и психических расстройствах, полиомиелите (за исключением формы бульбарного энцефалита).\u003Cbr\u003EСледует соблюдать осторожность при лечении больных с сердечно-сосудистыми заболеваниями, в т.ч. после недавно перенесенного инфаркта миокарда (у больных с острым и подострым инфарктом миокарда возможно распространение очага некроза, замедление формирования рубцовой ткани и вследствие этого - разрыв сердечной мышцы), декомпенсированной хронической сердечной недостаточностью.\u003Cbr\u003EС осторожностью назначают при паразитарных и инфекционных заболеваниях (в настоящее время или недавно перенесенные, включая недавний контакт с больным) - простой герпес, опоясывающий герпес (виремическая фаза), ветряная оспа, корь, амебиаз, стронгилоидоз (установленный или подозреваемый); активный и латентный туберкулез. Применение при тяжелых, инфекционных заболеваниях допустимо только на фоне специфической противомикробной терапии.\u003Cbr\u003EСледует соблюдать осторожность при лечении больных в поствакцинальном периоде (период длительностью 8 недель до и 2 недели после вакцинации), лимфадените после прививки БЦЖ.\u003Cbr\u003EРешение о применении минералокортикостероидов у больных с ВИЧ-инфекцией и СПИД следует принимать после тщательной оценки соотношения ожидаемой пользы и потенциального риска.\u003Cbr\u003E\u003Cbr\u003EВ период лечения пациентам с сахарным диабетом необходим регулярный контроль уровня глюкозы в крови.\u003Cbr\u003EПри длительном лечении необходим контроль уровня калия в крови.\u003Cbr\u003EВ случае возникновения стрессовых ситуаций пациентам, принимающим флудрокортизон, рекомендовано парентеральное введение минералокортикостероидов.\u003Cbr\u003EВнезапное прекращение лечения может вызвать развитие острой недостаточности коры надпочечников, поэтому дозу флудрокортизона следует уменьшать постепенно.\u003Cbr\u003EПри внезапной отмене флудрокортизона, особенно после длительного приема, возможно развитие синдрома \"отмены\", проявляющегося анорексией, повышением температуры тела, мышечными и суставными болями, общей слабостью. Эти симптомы могут появиться даже в случае, когда не отмечено недостаточности коры надпочечников.\u003Cbr\u003EФлудрокортизон может маскировать симптомы инфекции, снижать устойчивость к инфекции способность к ее локализации.\u003Cbr\u003EДлительное применение флудрокортизона увеличивает риск развития вторичных грибковых или вирусных инфекций.\u003Cbr\u003EПациентов, принимающих флудрокортизон, не следует вакцинировать живыми вирусными вакцинами. Введение инактивированной вирусной или бактериальной вакцины может не вызвать ожидаемого увеличения количества антител. Кроме того, у больных, принимающих минералокортикостероиды, существует повышенный риск неврологических осложнений во время вакцинации.\u003Cbr\u003EУ больных с гипотиреозом или циррозом печени действие флудрокортизона усиливается.\u003Cbr\u003EПри лечении больных с гипопротромбинемией следует с осторожностью назначать одновременно флудрокортизон и ацетилсалициловую кислоту.\u003Cbr\u003EВ период применения флудрокортизона, во избежание появления отеков, повышения АД, необходимо ограничить потребление соли с пищей.\u003Cbr\u003E\u003Cbr\u003E"},{"name":"Взаимодействие","value":"При одновременном применении флудрокортизона и сердечных гликозидов повышается риск нарушений сердечного ритма и токсичности гликозидов, связанной с гипокалиемией.\u003Cbr\u003EПри одновременном применении барбитураты, противоэпилептические препараты (фенитоин, карбамазепин), рифампицин, глютетимид ускоряют метаболизм минералокортикостероидов (путем индукции микросомальных ферментов), ослабляют их действие.\u003Cbr\u003EПри одновременном применении антигистаминные препараты ослабляют действие флудрокортизона.\u003Cbr\u003EПри одновременном применении флудрокортизона и амфотерицина В, ингибиторов карбоангидразы возможны гипокалиемия, гипертрофия левого желудочка сердца, недостаточность кровообращения.\u003Cbr\u003EПри одновременном применении флудрокортизона и анаболических стероидов, андрогенов повышается риска развития периферических отеков, угрей.\u003Cbr\u003EПри одновременном применении пероральных контрацептивных препаратов, содержащих эстрогены, происходит увеличение концентрации глобулинов, связывающих минералокортикостероиды в сыворотке крови, замедление метаболизма, увеличение продолжительности полувыведения, усиление действия флудрокортизона.\u003Cbr\u003EПри одновременном применении флудрокортизона и антикоагулянтов (производные кумарина, индандион, гепарин), стрептокиназы, урокиназы возможно снижение, а у некоторых больных повышение эффективности; доза должна быть определена на основании протромбинового времени; повышается риск образования язвы и кровотечения из ЖКТ.\u003Cbr\u003EПри одновременном применении флудрокортизона и трициклических антидепрессантов возможно усиление нарушений психики, связанных с приемом флудрокортизона.\u003Cbr\u003EПри одновременном применении флудрокортизона и пероральных гипогликемических препаратов, инсулина возможно ослабление гипогликемического действия, увеличение концентрации глюкозы в крови.\u003Cbr\u003EПри одновременном применении флудрокортизона и калийсберегающих диуретиков происходит ослабление действия последних, гипокалиемия.\u003Cbr\u003EПри одновременном применении эфедрин может ускорять метаболизм минералокортикостероидов.\u003Cbr\u003EПри одновременном применении флудрокортизона и иммунодепрессивных препаратов повышается риска развития инфекции, лимфомы и других лимфопролиферативных заболеваний.\u003Cbr\u003EПри одновременном применении флудрокортизона и препаратов, блокирующих нервно-мышечную проводимость (деполяризующие миорелаксанты), гипокальциемия, связанная с применением флудрокортизона, может усиливать блокаду синапсов, приводя к увеличению продолжительности нервно-мышечной блокады.\u003Cbr\u003EПри одновременном применении флудрокортизона и НПВС, ацетилсалициловой кислоты возможно ослабление действия, повышение риска развития язвенной болезни и кровотечения из ЖКТ.\u003Cbr\u003EПри одновременном применении флудрокортизона и вакцин, содержащих живые вирусы, возможны репликация вирусов и развитие заболеваний; снижение выработки антител. При применении других вакцин повышается риск неврологических осложнений и снижение выработки антител.\u003Cbr\u003E\u003Cbr\u003E"},{"name":"Регистрационный номер","value":"ЛП-004507"},{"name":"Дата государственной регистрации","value":"25.10.2017, 23.06.2022"},{"name":"Владелец регистрационного удостоверения","value":"Фармасинтез-Тюмень","transition":{"type":"catalog","params":{"categorySlug":"sistemnye-gormonalnye-preparaty","categoryId":"15756915","navnodeId":"72510","glfilters":["34324371:35649313","7893318:17617388"]}}},{"name":"Изготовитель","value":"Фармасинтез-Тюмень"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Срок годности","value":"1 г."}]}},"fullSpecsGrouped":{"3356043425244839864":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"эндокринная система"},{"name":"Назначение","value":"надпочечниковая недостаточность"},{"name":"Показания к применению","value":"Первичная недостаточность коры надпочечников (болезнь Аддисона, состояние после полной адреналэктомии); вторичная недостаточность коры надпочечников; адреногенитальный синдром (врожденная гиперплазия надпочечников); гиповолемия и артериальная гипотензия различного генеза."},{"name":"Противопоказания","value":"Повышенная чувствительность к флудрокортизону; системные грибковые инфекции."},{"name":"Состав","value":"1 таб. содержит: флудрокортизона ацетат - 0.1 мг. Вспомогательные вещества: целлюлоза микрокристаллическая тип 200- 189.9 мг, повидон К25 - 8 мг, кремния диоксид коллоидный - 1 мг, магния стеарат - 1 мг.\u003Cbr\u003E"},{"name":"Действующее вещество","value":"Флудрокортизон"},{"name":"Способ применения и дозы","value":"Устанавливают индивидуально, в зависимости от показаний, эффективности терапии, состояния пациента и его возраста. В процессе лечения при изменении клинической картины или во время стрессовых ситуаций, таких как хирургическая операция, травма или инфекция, может быть необходима коррекция дозы."},{"name":"Побочные действия","value":"Со стороны эндокринной системы: возможны угнетение продукции АКТГ, повышение уровня глюкозы в крови, нарушения менструального цикла.\u003Cbr\u003EСо стороны обмена веществ: возможны угнетение синтеза белка, замедление роста у детей, отеки.\u003Cbr\u003EСо стороны пищеварительной системы: возможны эрозивно-язвенные поражения ЖКТ.\u003Cbr\u003EПрочие: возможны кожная сыпь, повышение АД.\u003Cbr\u003EПри местном применении: возможны повышение внутриглазного давления, образование субкапсулярной катаракты.\u003Cbr\u003E\u003Cbr\u003E"},{"name":"Фармакологическое действие","value":"Кортикостероид с выраженной минералокортикоидной активностью и глюкокортикоидной активностью. Минералокортикоидное действие обусловлено связыванием с минералокортикоидными рецепторами в цитоплазме клеток-мишеней, в первую очередь в клетках собирательных трубочек почек. В результате происходит увеличение реабсорбции натрия, выведение калия и водорода, при этом наблюдается задержка воды. Повышается также реабсорбция натрия в потовых и слюнных железах, слизистой оболочке ЖКТ и через клеточные мембраны. Обладая глюкокортикоидной активностью, флудрокортизон подавляет функции лейкоцитов и тканевых макрофагов. Ограничивает миграцию лейкоцитов в область воспаления. Нарушает способность макрофагов к фагоцитозу, а также к образованию интерлейкина-1. Способствует стабилизации лизосомальных мембран, снижая тем самым концентрацию протеолитических ферментов в области воспаления. Уменьшает проницаемость капилляров, обусловленную высвобождением гистамина. Подавляет активность фибробластов и образование коллагена. Флудрокортизон ингибирует активность фосфолипазы А2, что приводит к подавлению синтеза простагландинов и лейкотриенов; подавляет высвобождение ЦОГ (главным образом ЦОГ-2), что также способствует уменьшению выработки простагландинов. Уменьшает число циркулирующих лимфоцитов (T- и B-клеток), моноцитов, эозинофилов и базофилов вследствие их перемещения из сосудистого русла в лимфоидную ткань; подавляет образование антител. Флудрокортизон подавляет высвобождение гипофизом АКТГ и бета-липотропина, но не снижает уровень циркулирующего бета-эндорфина; угнетает секрецию ТТГ и ФСГ. При непосредственной аппликации на сосуды вызывает вазоконстрикторный эффект. Стимулирует глюконеогенез, способствует захвату аминокислот печенью и почками и повышает активность ферментов глюконеогенеза. В печени флудрокортизон усиливает депонирование гликогена, стимулируя активность гликогенсинтетазы и синтез глюкозы из продуктов белкового обмена. Повышение содержания глюкозы в крови активизирует выделение инсулина. Подавляет захват глюкозы жировыми клетками, что приводит к активации липолиза. Однако вследствие увеличения секреции инсулина происходит стимуляция липогенеза, что приводит к накоплению жира. Оказывает катаболическое действие в лимфоидной и соединительной ткани, мышцах, жировой ткани, коже, костной ткани. В результате катаболического действия возможно подавление роста у детей. В высоких дозах флудрокортизон может повышать возбудимость тканей мозга и способствует понижению порога судорожной готовности. Стимулирует избыточную продукцию хлористоводородной кислоты и пепсина в желудке, что способствует развитию пептической язвы. По сравнению с гидрокортизоном, способность флудрокортизона задерживать ионы натрия в организме выражена в 250 раз сильнее, противовоспалительная активность - в 10 раз сильнее.\u003Cbr\u003E\u003Cbr\u003E"},{"name":"Фармакологическая группа","value":"минералокортикостероиды"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"В защищенном от света месте, при температуре не выше 25 град."},{"name":"Применение при беременности и кормлении грудью","value":"Применение при беременности или у женщин, планирующих беременность, возможно только в тех случаях, когда предполагаемая польза для матери превышает потенциальный риск для плода. При необходимости применения в период лактации следует решить вопрос о прекращении грудного вскармливания."},{"name":"Особые указания","value":"С осторожностью\u003Cbr\u003EПри язвенном колите, дивертикулезе кишечника, язвенной болезни желудка или двенадцатиперстной кишки, острой или латентной пептической язве, недавно созданных анастомозах кишечника, эзофагите, гастрите, операциях на ЖКТ в анамнезе, нарушениях функции печени, почечной недостаточности, артериальной гипертензии, остеопорозе, миастении, гипоальбуминемии и состояниях, предрасполагающих к ее возникновению, гиперлипидемии; при сахарном диабете (в т.ч. нарушении толерантности к углеводам), гипотиреозе, болезни Иценко-Кушинга, тиреотоксикозе, ожирении (III-IV ст.), остром психозе и психических расстройствах, полиомиелите (за исключением формы бульбарного энцефалита).\u003Cbr\u003EСледует соблюдать осторожность при лечении больных с сердечно-сосудистыми заболеваниями, в т.ч. после недавно перенесенного инфаркта миокарда (у больных с острым и подострым инфарктом миокарда возможно распространение очага некроза, замедление формирования рубцовой ткани и вследствие этого - разрыв сердечной мышцы), декомпенсированной хронической сердечной недостаточностью.\u003Cbr\u003EС осторожностью назначают при паразитарных и инфекционных заболеваниях (в настоящее время или недавно перенесенные, включая недавний контакт с больным) - простой герпес, опоясывающий герпес (виремическая фаза), ветряная оспа, корь, амебиаз, стронгилоидоз (установленный или подозреваемый); активный и латентный туберкулез. Применение при тяжелых, инфекционных заболеваниях допустимо только на фоне специфической противомикробной терапии.\u003Cbr\u003EСледует соблюдать осторожность при лечении больных в поствакцинальном периоде (период длительностью 8 недель до и 2 недели после вакцинации), лимфадените после прививки БЦЖ.\u003Cbr\u003EРешение о применении минералокортикостероидов у больных с ВИЧ-инфекцией и СПИД следует принимать после тщательной оценки соотношения ожидаемой пользы и потенциального риска.\u003Cbr\u003E\u003Cbr\u003EВ период лечения пациентам с сахарным диабетом необходим регулярный контроль уровня глюкозы в крови.\u003Cbr\u003EПри длительном лечении необходим контроль уровня калия в крови.\u003Cbr\u003EВ случае возникновения стрессовых ситуаций пациентам, принимающим флудрокортизон, рекомендовано парентеральное введение минералокортикостероидов.\u003Cbr\u003EВнезапное прекращение лечения может вызвать развитие острой недостаточности коры надпочечников, поэтому дозу флудрокортизона следует уменьшать постепенно.\u003Cbr\u003EПри внезапной отмене флудрокортизона, особенно после длительного приема, возможно развитие синдрома \"отмены\", проявляющегося анорексией, повышением температуры тела, мышечными и суставными болями, общей слабостью. Эти симптомы могут появиться даже в случае, когда не отмечено недостаточности коры надпочечников.\u003Cbr\u003EФлудрокортизон может маскировать симптомы инфекции, снижать устойчивость к инфекции способность к ее локализации.\u003Cbr\u003EДлительное применение флудрокортизона увеличивает риск развития вторичных грибковых или вирусных инфекций.\u003Cbr\u003EПациентов, принимающих флудрокортизон, не следует вакцинировать живыми вирусными вакцинами. Введение инактивированной вирусной или бактериальной вакцины может не вызвать ожидаемого увеличения количества антител. Кроме того, у больных, принимающих минералокортикостероиды, существует повышенный риск неврологических осложнений во время вакцинации.\u003Cbr\u003EУ больных с гипотиреозом или циррозом печени действие флудрокортизона усиливается.\u003Cbr\u003EПри лечении больных с гипопротромбинемией следует с осторожностью назначать одновременно флудрокортизон и ацетилсалициловую кислоту.\u003Cbr\u003EВ период применения флудрокортизона, во избежание появления отеков, повышения АД, необходимо ограничить потребление соли с пищей.\u003Cbr\u003E\u003Cbr\u003E"},{"name":"Взаимодействие","value":"При одновременном применении флудрокортизона и сердечных гликозидов повышается риск нарушений сердечного ритма и токсичности гликозидов, связанной с гипокалиемией.\u003Cbr\u003EПри одновременном применении барбитураты, противоэпилептические препараты (фенитоин, карбамазепин), рифампицин, глютетимид ускоряют метаболизм минералокортикостероидов (путем индукции микросомальных ферментов), ослабляют их действие.\u003Cbr\u003EПри одновременном применении антигистаминные препараты ослабляют действие флудрокортизона.\u003Cbr\u003EПри одновременном применении флудрокортизона и амфотерицина В, ингибиторов карбоангидразы возможны гипокалиемия, гипертрофия левого желудочка сердца, недостаточность кровообращения.\u003Cbr\u003EПри одновременном применении флудрокортизона и анаболических стероидов, андрогенов повышается риска развития периферических отеков, угрей.\u003Cbr\u003EПри одновременном применении пероральных контрацептивных препаратов, содержащих эстрогены, происходит увеличение концентрации глобулинов, связывающих минералокортикостероиды в сыворотке крови, замедление метаболизма, увеличение продолжительности полувыведения, усиление действия флудрокортизона.\u003Cbr\u003EПри одновременном применении флудрокортизона и антикоагулянтов (производные кумарина, индандион, гепарин), стрептокиназы, урокиназы возможно снижение, а у некоторых больных повышение эффективности; доза должна быть определена на основании протромбинового времени; повышается риск образования язвы и кровотечения из ЖКТ.\u003Cbr\u003EПри одновременном применении флудрокортизона и трициклических антидепрессантов возможно усиление нарушений психики, связанных с приемом флудрокортизона.\u003Cbr\u003EПри одновременном применении флудрокортизона и пероральных гипогликемических препаратов, инсулина возможно ослабление гипогликемического действия, увеличение концентрации глюкозы в крови.\u003Cbr\u003EПри одновременном применении флудрокортизона и калийсберегающих диуретиков происходит ослабление действия последних, гипокалиемия.\u003Cbr\u003EПри одновременном применении эфедрин может ускорять метаболизм минералокортикостероидов.\u003Cbr\u003EПри одновременном применении флудрокортизона и иммунодепрессивных препаратов повышается риска развития инфекции, лимфомы и других лимфопролиферативных заболеваний.\u003Cbr\u003EПри одновременном применении флудрокортизона и препаратов, блокирующих нервно-мышечную проводимость (деполяризующие миорелаксанты), гипокальциемия, связанная с применением флудрокортизона, может усиливать блокаду синапсов, приводя к увеличению продолжительности нервно-мышечной блокады.\u003Cbr\u003EПри одновременном применении флудрокортизона и НПВС, ацетилсалициловой кислоты возможно ослабление действия, повышение риска развития язвенной болезни и кровотечения из ЖКТ.\u003Cbr\u003EПри одновременном применении флудрокортизона и вакцин, содержащих живые вирусы, возможны репликация вирусов и развитие заболеваний; снижение выработки антител. При применении других вакцин повышается риск неврологических осложнений и снижение выработки антител.\u003Cbr\u003E\u003Cbr\u003E"},{"name":"Регистрационный номер","value":"ЛП-004507"},{"name":"Дата государственной регистрации","value":"25.10.2017, 23.06.2022"},{"name":"Владелец регистрационного удостоверения","value":"Фармасинтез-Тюмень"},{"name":"Изготовитель","value":"Фармасинтез-Тюмень"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Срок годности","value":"1 г."}]}],"transitionId":"tr_16923474345678955955"}}}}
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    Цена 796 ₽
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  • Дипромета сусп. д/ин. шприц, 7 мг/мл, 1 мл
    –15 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-7bbpo6ux8sc/toggleWishlist":{"skuId":"889961010","productId":1778176845,"offerId":"Fzf4WrxzMtKtN34cetdXZA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQu73stvyLptcREjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIzabzzwYQsvSuqAMYisTZByDz3MEH","sign":"Y1anMShx0+u8tpyWAiqO3BMCn+09r4rZym1X5k9FVC0="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-7bbpo6ux8sc/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Дипромета сусп. д/ин. шприц, 7 мг/мл, 1 мл

    Рейтинг товара: 5 из 5
    на основе 7 оценок
    Цена 910 ₽ вместо 1 065
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  • Дексаметазон таб., 0.5 мг, 56 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-l3hm98gtvm/toggleWishlist":{"skuId":"227830194","productId":1778176991,"offerId":"f8sP2GAOhnqQQiPrPZoIeg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQu73stvyLptcREjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI36fzzwYQstPRbBjyrIIIIPPcwQc=","sign":"3FhctN5Z63lU/Cf4I23og1TgW5ZMYGIy0D1ZCqqeyM4="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-l3hm98gtvm/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Дексаметазон таб., 0.5 мг, 56 шт.

    Рейтинг товара: 4.5 из 5
    на основе 4 оценки
    Цена 101 ₽
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  • Кеналог сусп. д/ин., 40 мг/мл, 1 мл, 5 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-xbgu3cfxse/toggleWishlist":{"skuId":"265318685","productId":1778177017,"offerId":"Krr9rp9WjIdvrqDApKbzYw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQu73stvyLptcREjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI+afzzwYQneLBfhi21YcEIPPcwQc=","sign":"tCIFOb954WBVuQHEomHg6NA4Ur6tbLu9u2rofwILpik="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-xbgu3cfxse/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Кеналог сусп. д/ин., 40 мг/мл, 1 мл, 5 шт.

    Рейтинг товара: 4.3 из 5
    на основе 6 оценок
    Цена 1 159 ₽
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  • Сандостатин р-р для в/в введ. и п/к введ., 0.05 мг/мл, 1 мл, 5 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-jo8kovquxnl/toggleWishlist":{"skuId":"101773603744","productId":666137001,"offerId":"E5S8WKUSwEqV8fz8hcy2qQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQu73stvyLptcREjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIqePRvQIQoOe3kfsCGK6PmREg89zBBw==","sign":"AFNnTbhaU6E4Sq1Jbu1eFrbeLnzC620LCn2vJ/7fVwU="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-jo8kovquxnl/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Сандостатин р-р для в/в введ. и п/к введ., 0.05 мг/мл, 1 мл, 5 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 382 ₽
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  • Флостерон сусп. д/ин., 7 мг/мл, 1 мл, 1 шт.
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    Флостерон сусп. д/ин., 7 мг/мл, 1 мл, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 9 оценок
    Цена 619 ₽
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  • Минирин таб., 0.1 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-w62z9mb1bv9/toggleWishlist":{"skuId":"460216219","productId":1436732425,"offerId":"X1PDTLsjB5uN4ivXN04gvQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQu73stvyLptcREjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIiZiLrQUQm6+52wEY7N3QByDz3MEH","sign":"tAifTX23UrC32HZqyuyUzi51yIw3HGLELWOHXchyIUw="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-w62z9mb1bv9/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Минирин таб., 0.1 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 789 ₽
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  • Гидрокортизон-рихтер сусп. для в/суст. и околосуст. введ., 25 мг+5 мг/мл, 5 мл
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-8b2u5cmi8nk/toggleWishlist":{"skuId":"101475288736","productId":227814165,"offerId":"7HNVvuOPJEtlTkZpf4x2zQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQu73stvyLptcREjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIldbQbBCgjZiD+gIY/tW2CCDz3MEH","sign":"yc1+Gkp+v9OEZvcWQJGdMY1lkyVgehroDUo3n6k0zbA="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-8b2u5cmi8nk/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Гидрокортизон-рихтер сусп. для в/суст. и околосуст. введ., 25 мг+5 мг/мл, 5 мл

    Рейтинг товара: 5 из 5
    на основе 7 оценок
    Цена 514 ₽
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  • Десмопрессин таб., 0.1 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-r2xxq4p5ckg/toggleWishlist":{"skuId":"228044228","productId":1401075681,"offerId":"ufKb7KQm20Ry9iCH6LmEBA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQu73stvyLptcREjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI4e+KnAUQxNvebBiEqbIIIPPcwQc=","sign":"+bIMJ0l6c7Ix57xPGoPnDEqzZ+1DLjd/bgZNBHXAT4M="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-r2xxq4p5ckg/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Десмопрессин таб., 0.1 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 791 ₽
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  • Дексаметазон р-р д/ин., 4 мг/мл, 2 мл, 10 шт.
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    Дексаметазон р-р д/ин., 4 мг/мл, 2 мл, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 7 оценок
    Цена 140 ₽
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  • Солу-кортеф лиоф. для приг. р-ра для в/в и в/м введ., 100 мг, 1 шт.
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    Солу-кортеф лиоф. для приг. р-ра для в/в и в/м введ., 100 мг, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 7 оценок
    Цена 104 ₽
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Инструкция

Показания к применению

Первичная недостаточность коры надпочечников (болезнь Аддисона, состояние после полной адреналэктомии); вторичная недостаточность коры надпочечников; адреногенитальный синдром (врожденная гиперплазия надпочечников); гиповолемия и артериальная гипотензия различного генеза.

Противопоказания

Повышенная чувствительность к флудрокортизону; системные грибковые инфекции.

Способ применения и дозы

Устанавливают индивидуально, в зависимости от показаний, эффективности терапии, состояния пациента и его возраста. В процессе лечения при изменении клинической картины или во время стрессовых ситуаций, таких как хирургическая операция, травма или инфекция, может быть необходима коррекция дозы.
Полная инструкция
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Зифлукорт таб.
Зифлукорт таб., 0.1 мг, 20 шт.
У продавца: 
нет • На Маркете: 4.8
(4)
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Задать вопрос
Инструкция

513 ₽

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Нет отзывов у этого продавца
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У других продавцов:4 оценки·3 отзыва
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