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Биманокс гл. капли, 0.2%, 5 мл

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У продавца: 
нет • На Маркете: 5.0
(7)
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Коротко о товаре

Артикул Маркета
4632484285
Тип препарата
Назначение
Действующее вещество
Возраст
от 2 лет
Инструкция
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В конъюнктивальный мешок пораженного глаза по 1 капле 2 раза в сутки с интервалом между введениями около 12 часов.\u003Cbr /\u003EДля снижения системной экспозиции препарата сразу после закапывания следует надавить на область слезного мешка у внутреннего угла глаза (закрывая слезную точку) в течение 1 минуты.\u003Cbr /\u003EБиманокс® можно применять с другими офтальмологическими препаратами с целью снижения внутриглазного давления. Если используют более 2 лекарственных препаратов, то необходимо сделать 15-минутный перерыв между инстилляциями.\u003Cbr /\u003EПрименение Биманокса® не изучали у пациентов с нарушением функции печени или почек; при лечении таких пациентов необходимо соблюдать осторожность.\u003Cbr /\u003EИзбегайте контакта с мягкими контактными линзами. Снимите контактные линзы перед применением и наденьте линзы через 15 минут после применения препарата.\u003Cbr /\u003EПрименение у детей\u003Cbr /\u003EВ трехмесячном исследовании фазы 3 у детей в возрасте от 2 до 7 лет с глаукомой и с недостаточным контролем заболевания при применении бета-блокаторов сообщалось о высокой частоте возникновения сонливости (55%) при применении 0,2% бримонидина в качестве дополнительной терапии. Сонливость была сильно выражена у 8% детей и являлась причиной прекращения лечения в 13% случаев. Частота сонливости снижалась с увеличением возраста и была минимальной у 7-летних детей (25%), но в большей степени определялась массой тела: сонливость чаще отмечалась у детей с массой ≤20 кг (63%) по сравнению с детьми с массой \u003E20 кг (25%).\u003Cbr /\u003EБезопасность и эффективность Биманокса® у детей младше 2 лет не установлены.\u003Cbr /\u003E"},{"name":"Побочные действия","value":"Наиболее часто встречаемыми нежелательными реакциями со стороны органа зрения являются аллергический конъюнктивит, гиперемия конъюнктивы, зуд слизистой оболочки глаз и кожи век.\u003Cbr /\u003EБольшинство нежелательных реакций имели быстропроходящий характер и легкую степень тяжести (не требующую прекращения лечения).\u003Cbr /\u003EПо данным клинических исследований симптомы аллергических реакций со стороны глаз наблюдались в 12,7% случаев (являясь причиной прекращения лечения в 11,5%), при этом у большинства пациентов они проявились через 3-6 месяцев применения препарата (согласно актуальной информации об опыте применения препарата Биманокс® в концентрации 0,2%).\u003Cbr /\u003EЧастота побочных эффектов, выявленных в ходе исследований, оценивалась следующим образом: очень часто (\u003E10%), часто (\u003E1% и \u003C10%); нечасто (\u003E0,1% и \u003C1%), редко (\u003E0,01% и \u003C0,1%).\u003Cbr /\u003EВ клинических исследованиях препарата Биманокс® выявлены следующие побочные эффекты:\u003Cbr /\u003EСо стороны органа зрения:\u003Cbr /\u003EОчень часто: аллергический конъюнктивит, гиперемия конъюнктивы, зуд слизистой оболочки глаз и кожи век, затуманивание зрения.\u003Cbr /\u003EЧасто: ощущение жжения, фолликулез конъюнктивы или фолликулярный конъюнктивит, местные аллергические реакции со стороны глаз (в т.ч. кератоконъюнктивит), нарушение зрения, блефарит, блефароконъюнктивит, катаракта, отек конъюнктивы, кровоизлияние в конъюнктиву, конъюнктивит, ретенционное слезотечение, эпифора, слизистое отделяемое из глаз, сухость и раздражение слизистой оболочки глаз, боль в глазу, отек век, покраснение век, ощущение инородного тела в глазах, кератит, поражения век, фотосенсибилизация, колющее ощущение в глазу, поверхностная точечная кератопатия, слезотечение, выпадение полей зрения, отслойка стекловидного тела, кровоизлияния в стекловидное тело, плавающие помутнения в стекловидном теле и снижение остроты зрения.\u003Cbr /\u003EНечасто: эрозия роговицы, ячмень.\u003Cbr /\u003EСо стороны центральной нервной системы:\u003Cbr /\u003EЧасто: головная боль, сонливость, бессонница, головокружение.\u003Cbr /\u003EСо стороны сердечно-сосудистой системы:\u003Cbr /\u003EЧасто: повышение или снижение артериального давления.\u003Cbr /\u003EСо стороны органов дыхания:\u003Cbr /\u003EЧасто: бронхит, фарингит, кашель, одышка.\u003Cbr /\u003EНечасто: сухость слизистой оболочки носа, апноэ.\u003Cbr /\u003EСо стороны желудочно-кишечного тракта:\u003Cbr /\u003EЧасто: желудочно-кишечные расстройства – диспепсия, сухость слизистой оболочки полости рта.\u003Cbr /\u003EСо стороны кожи и подкожно-жировой клетчатки\u003Cbr /\u003EЧасто: сыпь.\u003Cbr /\u003EИнфекционные и паразитарные заболевания:\u003Cbr /\u003EЧасто: гриппоподобный синдром, инфекционное заболевание (озноб и респираторная инфекция), ринит, синусит, в т.ч. инфекционный.\u003Cbr /\u003EЛабораторные показатели:\u003Cbr /\u003EЧасто: гиперхолестеринемия.\u003Cbr /\u003EДругие:\u003Cbr /\u003EЧасто: общие аллергические реакции, астения, утомляемость, нарушение вкуса.\u003Cbr /\u003EНечасто: извращение вкуса.\u003Cbr /\u003EУ детей (в том числе у новорожденных и грудных детей) отмечено: апноэ, брадикардия, снижение артериального давления (АД), гипотермия, мышечная гипотония, бледность, сонливость, снижение внимания.\u003Cbr /\u003EОтдельные серьёзные побочные реакции, такие как возникновение комы, летаргии и угнетения дыхания у новорожденного и грудного ребенка, т.е. в возрасте, в котором использование препарата не одобрено, отмечались при применении препарата в концентрации 0,2%, превышающей концентрацию данного препарата.\u003Cbr /\u003EВ постмаркетинговый период дополнительно получены сообщения о следующих побочных эффектах:\u003Cbr /\u003EСо стороны органа зрения:\u003Cbr /\u003EЧастота неизвестна: ирит, сухой кератоконъюнктивит, миоз.\u003Cbr /\u003EСо стороны центральной нервной системы: депрессия, синкопе.\u003Cbr /\u003EСо стороны сердечно-сосудистой системы: брадикардия, тахикардия.\u003Cbr /\u003EСо стороны желудочно-кишечного тракта: тошнота.\u003Cbr /\u003EСо стороны кожи и подкожно-жировой клетчатки: местные кожные реакции (эритема, зуд век, отек лица, сыпь и вазодилатация сосудов кожи век и лица), гиперчувствительность.\u003Cbr /\u003E"},{"name":"Фармакологическое действие","value":"Бримонидин – селективный алъфа2-адреномиметик, оказывающий стимулирующее действие на альфа2-адренорецепторы. Гипотензивное действие бримонидина обеспечивается за счет снижения образования и повышения оттока внутриглазной жидкости по увеосклеральному пути. При применении Биманокса®, капли глазные, 0,2%, максимальное снижение внутриглазного давления достигается через 2 часа."},{"name":"Фармакологическая группа","value":"противоглаукомное средство - альфа 2-адреномиметик селективный"},{"name":"Форма выпуска","value":"капли"},{"name":"Способ применения/введения","value":"конъюктивальный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["35947170:36763746"]}}},{"name":"Минимальный возраст применения","value":"от 2 лет"},{"name":"Условия хранения","value":"При температуре не выше 25°С.\u003Cbr /\u003EХранить в недоступном для детей месте.\u003Cbr /\u003E"},{"name":"Передозировка","value":"Передозировка при местном применении\u003Cbr /\u003EСимптомы передозировки при местном применении представлены ранее отмеченными нежелательными реакциями.\u003Cbr /\u003EПередозировка при случайном проглатывании\u003Cbr /\u003EСообщений о случаях передозировки препарата у взрослых достаточно мало.\u003Cbr /\u003EНа сегодняшний день зарегистрирована одна нежелательная реакция, связанная со снижением артериального давления (АД). При развитии артериальной гипотензии впоследствии отмечалась рикошетная гипертензия.\u003Cbr /\u003EПри случайном приеме препарата внутрь возможны следующие симптомы: угнетение центральной нервной системы, сонливость, угнетение и потеря сознания, снижение АД, брадикардия, снижение температуры тела, цианоз кожных покровов, апноэ, астения, рвота, судороги, аритмия, миоз.\u003Cbr /\u003EПри выявлении симптомов передозировки необходимо проведение симптоматической терапии, контроль проходимости дыхательных путей.\u003Cbr /\u003EПередозировка у детей\u003Cbr /\u003EСимптомы передозировки бримонидином наблюдались при лечении врожденной глаукомы или случайном приеме внутрь у детей младшего возраста. В случае развития передозировки требуются поддерживающая и симптоматическая терапия, а также может быть необходима интенсивная терапия с применением интубации. Полное купирование симптомов передозировки бримонидином во всех сообщенных случаях происходило в течение 6-24 часов.\u003Cbr /\u003E"},{"name":"Применение при беременности и кормлении грудью","value":"В период беременности Биманокс® следует применять только в тех случаях, когда ожидаемая польза для матери значительно превышает возможный риск для плода.\u003Cbr /\u003EВ исследованиях на животных установлено, что бримонидин проникает в грудное молоко. Биманокс® не следует применять в период кормления грудью.\u003Cbr /\u003E"},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Прием препарата Биманокс® может сопровождаться эпизодами слабости и сонливости у некоторых больных. В том случае, если работа пациента связана с потенциально опасными видами деятельности, вождением автотранспортных средств, необходимо заранее предупредить пациента о возможном снижении концентрации внимания и скорости психомоторных реакций, и рекомендовать воздержаться от этих видов деятельности."},{"name":"Особые указания","value":"Необходимы тщательное наблюдение и мониторинг состояния пациентов в возрасте от 2 до 7 лет (особенно с массой тела до 20 кг) в связи с высокой частотой встречаемости и выраженности сонливости.\u003Cbr /\u003EПри развитии аллергических реакций на препарат Биманокс® необходимо прекратить лечение и обратиться к врачу.\u003Cbr /\u003EВозможно повышение внутриглазного давления в случае развития реакций замедленной гиперчувствительности.\u003Cbr /\u003EСообщалось о случаях бактериального кератита при использовании многодозовых флаконов офтальмологических средств для местного применения, инфицированных пациентами, которые, в большинстве случаев, имели сопутствующее заболевание роговицы или сопутствующее поражение эпителия роговицы и конъюнктивы.\u003Cbr /\u003EПри неправильном обращении или если наконечник флакона соприкасается с глазом или, окружающими глаз структурами, офтальмологические препараты могут инфицироваться бактериями, вызывающими глазные инфекции.\u003Cbr /\u003EИспользование инфицированного раствора может привести к серьезному повреждению глаза с последующей потерей зрения. Не использовать раствор после истечения срока годности, указанного на флаконе.\u003Cbr /\u003EЕсли была перенесена офтальмологическая операция или возникло сопутствующее глазное заболевание (напр., травма или инфекция), то следует немедленно проконсультироваться с врачом касательно продолжения использования данного многодозового флакона.\u003Cbr /\u003EПосле первого вскрытия флакона использовать в течение 28 дней.\u003Cbr /\u003EВозможно развитие точечной или язвенной токсической кератопатии при длительном применении препарата в связи с наличием в составе консерванта бензалкония хлорида. Требуется тщательный контроль за состоянием роговицы у пациентов с сопутствующим синдромом «сухого» глаза и другими заболеваниями роговицы в период терапии препаратом.\u003Cbr /\u003EБензалкония хлорид может вызывать раздражение глаз и обесцвечивать мягкие контактные линзы, в связи с чем перед применением препарата контактные линзы необходимо снять и установить обратно не ранее, чем через 15 минут после инстилляции препарата.\u003Cbr /\u003E"},{"name":"Взаимодействие","value":"Исследований по изучению лекарственного взаимодействия препарата Биманокс® не проводилось, однако при одновременном применении следует учитывать возможность усиления эффекта лекарственных средств, угнетающих центральную нервную систему (алкоголь, барбитураты, производные опия, седативные препараты, общие анестетики). Учитывая способность препаратов группы альфа-адреномиметиков снижать артериальное давление и частоту сердечных сокращений (ЧСС), с осторожностью следует одновременно применять гипотензивные лекарственные препараты и сердечные гликозиды.\u003Cbr /\u003EВ связи с известным уменьшением выраженности гипотензивного эффекта клонидина (альфа2-адреномиметик) при совместном применении с трициклическими антидепрессантами, нельзя исключить возможного снижения эффективности препарата Биманокс при сопутствующем лечении трициклическими антидепрессантами.\u003Cbr /\u003EС осторожностью следует применять препарат Биманокс® с трициклическими антидепрессантами, которые могут оказывать влияние на метаболизм аминов и их распределение в сосудистом русле.\u003Cbr /\u003E"},{"name":"Регистрационный номер","value":"ЛП-007731"},{"name":"Дата государственной регистрации","value":"27.12.2021"},{"name":"Владелец регистрационного удостоверения","value":"JADRAN-GALENSKI LABORATORIJ, d.d.","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["34324371:35649313","7893318:17533355"]}}},{"name":"Страна бренда","value":"Хорватия"},{"name":"Страна-производитель","value":"Хорватия"},{"name":"Срок годности","value":"1 г."}]}},"fullSpecsGrouped":{"3393979501640370818":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"глаза"},{"name":"Назначение","value":"открытоугольная глаукома, офтальмогипертензия"},{"name":"Показания к применению","value":"Открытоугольная глаукома.\u003Cbr /\u003EОфтальмогипертензия (в монотерапии или в комбинации с другими препаратами, снижающими внутриглазное давление).\u003Cbr /\u003E"},{"name":"Противопоказания","value":"Гиперчувствительность к бримонидину и другим компонентам препарата.\u003Cbr /\u003EДетский возраст до 2 лет, низкая масса тела (до 20 кг).\u003Cbr /\u003EОдновременная терапия ингибиторами моноаминоксидазы (МАО).\u003Cbr /\u003EОдновременная терапия антидепрессантами, которая влияет на норадренергическую передачу (например, трициклические антидепрессанты и миансерин).\u003Cbr /\u003EПериод кормления грудью.\u003Cbr /\u003EС осторожностью:\u003Cbr /\u003EОртостатическая гипотензия, сердечная недостаточность, цереброваскулярные заболевания, приводящие к недостаточности мозгового кровообращения, почечная недостаточность (клиренс креатинина ниже 40 мл/мин), печеночная недостаточность, депрессия, синдром Рейно, облитерирующий тромбангиит, детский возраст от 2 до 7 лет.\u003Cbr /\u003E"},{"name":"Состав","value":"Состав (на 1 мл):\u003Cbr /\u003EДействующее вещество: бримонидина тартрат – 2,00 мг.\u003Cbr /\u003EВспомогательные вещества: бензалкония хлорид 50% раствор (в пересчете на бензалкония хлорид) – 0,10 мг (0,05 мг), поливиниловый спирт (40-88) – 14,16 мг, натрия цитрата дигидрат – 6,04 мг, лимонной кислоты моногидрат – 0,46 мг, натрия хлорид – 6,90 мг, натрия гидроксид / хлористоводородная кислота 1 М – до pH 6,0-6,5, вода очищенная – до 1,0 мл.\u003Cbr /\u003E"},{"name":"Действующее вещество","value":"Бримонидин"},{"name":"Способ применения и дозы","value":"Местно. В конъюнктивальный мешок пораженного глаза по 1 капле 2 раза в сутки с интервалом между введениями около 12 часов.\u003Cbr /\u003EДля снижения системной экспозиции препарата сразу после закапывания следует надавить на область слезного мешка у внутреннего угла глаза (закрывая слезную точку) в течение 1 минуты.\u003Cbr /\u003EБиманокс® можно применять с другими офтальмологическими препаратами с целью снижения внутриглазного давления. Если используют более 2 лекарственных препаратов, то необходимо сделать 15-минутный перерыв между инстилляциями.\u003Cbr /\u003EПрименение Биманокса® не изучали у пациентов с нарушением функции печени или почек; при лечении таких пациентов необходимо соблюдать осторожность.\u003Cbr /\u003EИзбегайте контакта с мягкими контактными линзами. Снимите контактные линзы перед применением и наденьте линзы через 15 минут после применения препарата.\u003Cbr /\u003EПрименение у детей\u003Cbr /\u003EВ трехмесячном исследовании фазы 3 у детей в возрасте от 2 до 7 лет с глаукомой и с недостаточным контролем заболевания при применении бета-блокаторов сообщалось о высокой частоте возникновения сонливости (55%) при применении 0,2% бримонидина в качестве дополнительной терапии. Сонливость была сильно выражена у 8% детей и являлась причиной прекращения лечения в 13% случаев. Частота сонливости снижалась с увеличением возраста и была минимальной у 7-летних детей (25%), но в большей степени определялась массой тела: сонливость чаще отмечалась у детей с массой ≤20 кг (63%) по сравнению с детьми с массой \u003E20 кг (25%).\u003Cbr /\u003EБезопасность и эффективность Биманокса® у детей младше 2 лет не установлены.\u003Cbr /\u003E"},{"name":"Побочные действия","value":"Наиболее часто встречаемыми нежелательными реакциями со стороны органа зрения являются аллергический конъюнктивит, гиперемия конъюнктивы, зуд слизистой оболочки глаз и кожи век.\u003Cbr /\u003EБольшинство нежелательных реакций имели быстропроходящий характер и легкую степень тяжести (не требующую прекращения лечения).\u003Cbr /\u003EПо данным клинических исследований симптомы аллергических реакций со стороны глаз наблюдались в 12,7% случаев (являясь причиной прекращения лечения в 11,5%), при этом у большинства пациентов они проявились через 3-6 месяцев применения препарата (согласно актуальной информации об опыте применения препарата Биманокс® в концентрации 0,2%).\u003Cbr /\u003EЧастота побочных эффектов, выявленных в ходе исследований, оценивалась следующим образом: очень часто (\u003E10%), часто (\u003E1% и \u003C10%); нечасто (\u003E0,1% и \u003C1%), редко (\u003E0,01% и \u003C0,1%).\u003Cbr /\u003EВ клинических исследованиях препарата Биманокс® выявлены следующие побочные эффекты:\u003Cbr /\u003EСо стороны органа зрения:\u003Cbr /\u003EОчень часто: аллергический конъюнктивит, гиперемия конъюнктивы, зуд слизистой оболочки глаз и кожи век, затуманивание зрения.\u003Cbr /\u003EЧасто: ощущение жжения, фолликулез конъюнктивы или фолликулярный конъюнктивит, местные аллергические реакции со стороны глаз (в т.ч. кератоконъюнктивит), нарушение зрения, блефарит, блефароконъюнктивит, катаракта, отек конъюнктивы, кровоизлияние в конъюнктиву, конъюнктивит, ретенционное слезотечение, эпифора, слизистое отделяемое из глаз, сухость и раздражение слизистой оболочки глаз, боль в глазу, отек век, покраснение век, ощущение инородного тела в глазах, кератит, поражения век, фотосенсибилизация, колющее ощущение в глазу, поверхностная точечная кератопатия, слезотечение, выпадение полей зрения, отслойка стекловидного тела, кровоизлияния в стекловидное тело, плавающие помутнения в стекловидном теле и снижение остроты зрения.\u003Cbr /\u003EНечасто: эрозия роговицы, ячмень.\u003Cbr /\u003EСо стороны центральной нервной системы:\u003Cbr /\u003EЧасто: головная боль, сонливость, бессонница, головокружение.\u003Cbr /\u003EСо стороны сердечно-сосудистой системы:\u003Cbr /\u003EЧасто: повышение или снижение артериального давления.\u003Cbr /\u003EСо стороны органов дыхания:\u003Cbr /\u003EЧасто: бронхит, фарингит, кашель, одышка.\u003Cbr /\u003EНечасто: сухость слизистой оболочки носа, апноэ.\u003Cbr /\u003EСо стороны желудочно-кишечного тракта:\u003Cbr /\u003EЧасто: желудочно-кишечные расстройства – диспепсия, сухость слизистой оболочки полости рта.\u003Cbr /\u003EСо стороны кожи и подкожно-жировой клетчатки\u003Cbr /\u003EЧасто: сыпь.\u003Cbr /\u003EИнфекционные и паразитарные заболевания:\u003Cbr /\u003EЧасто: гриппоподобный синдром, инфекционное заболевание (озноб и респираторная инфекция), ринит, синусит, в т.ч. инфекционный.\u003Cbr /\u003EЛабораторные показатели:\u003Cbr /\u003EЧасто: гиперхолестеринемия.\u003Cbr /\u003EДругие:\u003Cbr /\u003EЧасто: общие аллергические реакции, астения, утомляемость, нарушение вкуса.\u003Cbr /\u003EНечасто: извращение вкуса.\u003Cbr /\u003EУ детей (в том числе у новорожденных и грудных детей) отмечено: апноэ, брадикардия, снижение артериального давления (АД), гипотермия, мышечная гипотония, бледность, сонливость, снижение внимания.\u003Cbr /\u003EОтдельные серьёзные побочные реакции, такие как возникновение комы, летаргии и угнетения дыхания у новорожденного и грудного ребенка, т.е. в возрасте, в котором использование препарата не одобрено, отмечались при применении препарата в концентрации 0,2%, превышающей концентрацию данного препарата.\u003Cbr /\u003EВ постмаркетинговый период дополнительно получены сообщения о следующих побочных эффектах:\u003Cbr /\u003EСо стороны органа зрения:\u003Cbr /\u003EЧастота неизвестна: ирит, сухой кератоконъюнктивит, миоз.\u003Cbr /\u003EСо стороны центральной нервной системы: депрессия, синкопе.\u003Cbr /\u003EСо стороны сердечно-сосудистой системы: брадикардия, тахикардия.\u003Cbr /\u003EСо стороны желудочно-кишечного тракта: тошнота.\u003Cbr /\u003EСо стороны кожи и подкожно-жировой клетчатки: местные кожные реакции (эритема, зуд век, отек лица, сыпь и вазодилатация сосудов кожи век и лица), гиперчувствительность.\u003Cbr /\u003E"},{"name":"Фармакологическое действие","value":"Бримонидин – селективный алъфа2-адреномиметик, оказывающий стимулирующее действие на альфа2-адренорецепторы. Гипотензивное действие бримонидина обеспечивается за счет снижения образования и повышения оттока внутриглазной жидкости по увеосклеральному пути. При применении Биманокса®, капли глазные, 0,2%, максимальное снижение внутриглазного давления достигается через 2 часа."},{"name":"Фармакологическая группа","value":"противоглаукомное средство - альфа 2-адреномиметик селективный"},{"name":"Форма выпуска","value":"капли"},{"name":"Способ применения/введения","value":"конъюктивальный"},{"name":"Минимальный возраст применения","value":"от 2 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"При температуре не выше 25°С.\u003Cbr /\u003EХранить в недоступном для детей месте.\u003Cbr /\u003E"},{"name":"Передозировка","value":"Передозировка при местном применении\u003Cbr /\u003EСимптомы передозировки при местном применении представлены ранее отмеченными нежелательными реакциями.\u003Cbr /\u003EПередозировка при случайном проглатывании\u003Cbr /\u003EСообщений о случаях передозировки препарата у взрослых достаточно мало.\u003Cbr /\u003EНа сегодняшний день зарегистрирована одна нежелательная реакция, связанная со снижением артериального давления (АД). При развитии артериальной гипотензии впоследствии отмечалась рикошетная гипертензия.\u003Cbr /\u003EПри случайном приеме препарата внутрь возможны следующие симптомы: угнетение центральной нервной системы, сонливость, угнетение и потеря сознания, снижение АД, брадикардия, снижение температуры тела, цианоз кожных покровов, апноэ, астения, рвота, судороги, аритмия, миоз.\u003Cbr /\u003EПри выявлении симптомов передозировки необходимо проведение симптоматической терапии, контроль проходимости дыхательных путей.\u003Cbr /\u003EПередозировка у детей\u003Cbr /\u003EСимптомы передозировки бримонидином наблюдались при лечении врожденной глаукомы или случайном приеме внутрь у детей младшего возраста. В случае развития передозировки требуются поддерживающая и симптоматическая терапия, а также может быть необходима интенсивная терапия с применением интубации. Полное купирование симптомов передозировки бримонидином во всех сообщенных случаях происходило в течение 6-24 часов.\u003Cbr /\u003E"},{"name":"Применение при беременности и кормлении грудью","value":"В период беременности Биманокс® следует применять только в тех случаях, когда ожидаемая польза для матери значительно превышает возможный риск для плода.\u003Cbr /\u003EВ исследованиях на животных установлено, что бримонидин проникает в грудное молоко. Биманокс® не следует применять в период кормления грудью.\u003Cbr /\u003E"},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Прием препарата Биманокс® может сопровождаться эпизодами слабости и сонливости у некоторых больных. В том случае, если работа пациента связана с потенциально опасными видами деятельности, вождением автотранспортных средств, необходимо заранее предупредить пациента о возможном снижении концентрации внимания и скорости психомоторных реакций, и рекомендовать воздержаться от этих видов деятельности."},{"name":"Особые указания","value":"Необходимы тщательное наблюдение и мониторинг состояния пациентов в возрасте от 2 до 7 лет (особенно с массой тела до 20 кг) в связи с высокой частотой встречаемости и выраженности сонливости.\u003Cbr /\u003EПри развитии аллергических реакций на препарат Биманокс® необходимо прекратить лечение и обратиться к врачу.\u003Cbr /\u003EВозможно повышение внутриглазного давления в случае развития реакций замедленной гиперчувствительности.\u003Cbr /\u003EСообщалось о случаях бактериального кератита при использовании многодозовых флаконов офтальмологических средств для местного применения, инфицированных пациентами, которые, в большинстве случаев, имели сопутствующее заболевание роговицы или сопутствующее поражение эпителия роговицы и конъюнктивы.\u003Cbr /\u003EПри неправильном обращении или если наконечник флакона соприкасается с глазом или, окружающими глаз структурами, офтальмологические препараты могут инфицироваться бактериями, вызывающими глазные инфекции.\u003Cbr /\u003EИспользование инфицированного раствора может привести к серьезному повреждению глаза с последующей потерей зрения. Не использовать раствор после истечения срока годности, указанного на флаконе.\u003Cbr /\u003EЕсли была перенесена офтальмологическая операция или возникло сопутствующее глазное заболевание (напр., травма или инфекция), то следует немедленно проконсультироваться с врачом касательно продолжения использования данного многодозового флакона.\u003Cbr /\u003EПосле первого вскрытия флакона использовать в течение 28 дней.\u003Cbr /\u003EВозможно развитие точечной или язвенной токсической кератопатии при длительном применении препарата в связи с наличием в составе консерванта бензалкония хлорида. 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Учитывая способность препаратов группы альфа-адреномиметиков снижать артериальное давление и частоту сердечных сокращений (ЧСС), с осторожностью следует одновременно применять гипотензивные лекарственные препараты и сердечные гликозиды.\u003Cbr /\u003EВ связи с известным уменьшением выраженности гипотензивного эффекта клонидина (альфа2-адреномиметик) при совместном применении с трициклическими антидепрессантами, нельзя исключить возможного снижения эффективности препарата Биманокс при сопутствующем лечении трициклическими антидепрессантами.\u003Cbr /\u003EС осторожностью следует применять препарат Биманокс® с трициклическими антидепрессантами, которые могут оказывать влияние на метаболизм аминов и их распределение в сосудистом русле.\u003Cbr /\u003E"},{"name":"Регистрационный номер","value":"ЛП-007731"},{"name":"Дата государственной регистрации","value":"27.12.2021"},{"name":"Владелец регистрационного удостоверения","value":"JADRAN-GALENSKI LABORATORIJ, d.d."},{"name":"Страна бренда","value":"Хорватия"},{"name":"Страна-производитель","value":"Хорватия"},{"name":"Срок годности","value":"1 г."}]}],"transitionId":"tr_7172891696505209359"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

Где купить

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511 ₽

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    на основе 3 оценки
    Цена 211 ₽
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  • Дорзотимол гл. капли, 20 мг/мл + 5 мг/мл, 5 мл
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    Дорзотимол гл. капли, 20 мг/мл + 5 мг/мл, 5 мл

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 742 ₽
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  • Бримонидин-СЗ гл. капли фл., 2 мг/мл, 5 мл
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-txtitywj3gn/toggleWishlist":{"skuId":"101828303958","productId":1771808158,"offerId":"MNmbdKBW6j_yqC2dS-qpgw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ8Kj95M+doMUqEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcInsvuzAYQ1rjCq/sCGK7e0Acg3NzBBw==","sign":"JHjNtraLmDsp6r+9hl9tlZ+MfjWp2qHX5XqLY7wz7Gw="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-txtitywj3gn/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Бримонидин-СЗ гл. капли фл., 2 мг/мл, 5 мл

    Рейтинг товара: 4.8 из 5
    на основе 35 оценок
    Цена 575 ₽
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  • Бринекс-М гл. капли, 1%, 5 мл
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    Бринекс-М гл. капли, 1%, 5 мл

    Рейтинг товара: 4.7 из 5
    на основе 10 оценок
    Цена 975 ₽
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  • Сантабрим гл. капли, 0.1%, 5 мл
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-jtmt97jam9f/toggleWishlist":{"skuId":"101526473424","productId":1489418413,"offerId":"GNl-sDx7DolusKDedwBfWA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ8Kj95M+doMUqEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIrfGaxgUQ0JXMm/oCGOi+3gcg3NzBBw==","sign":"YGZox3XPibHJzwoUMz0W5yESKiKmEUFOckEhRjVKz5A="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-jtmt97jam9f/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Сантабрим гл. капли, 0.1%, 5 мл

    Рейтинг товара: 4.8 из 5
    на основе 9 оценок
    Цена 580 ₽
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  • Вигамокс гл. капли, 0,5%, 5 мл, 1 шт.
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    Вигамокс гл. капли, 0,5%, 5 мл, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 6 оценок
    Цена 252 ₽
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  • Бринзопт Плюс гл.капли фл., 10 мг/мл+5 мг/мл, 5 мл
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    Бринзопт Плюс гл.капли фл., 10 мг/мл+5 мг/мл, 5 мл

    Рейтинг товара: 4 из 5
    на основе 1 оценка
    Цена 860 ₽
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  • НЕПАФЕНАК-ОПТИК гл. капли фл.-кап., 1 мг/мл, 5 мл
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    НЕПАФЕНАК-ОПТИК гл. капли фл.-кап., 1 мг/мл, 5 мл

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 585 ₽
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  • Тимилокс фл., 0.5%, 5 мл
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-gk6hlm1v0i8/toggleWishlist":{"skuId":"101472356092","productId":1457412337,"offerId":"4SDglbOcC0UgZ1tOoWexFA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ8Kj95M+doMUqEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI8bH5tgUQ/I3lgfoCGIfe0Acg3NzBBw==","sign":"/bzDhYmjQ/FatUvPoHTaWyCFoLfuzEX56sHUU+5zpp4="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-gk6hlm1v0i8/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Тимилокс фл., 0.5%, 5 мл

    Цена 195 ₽
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  • Солосептин сенс капли, 0.01%, 10 мл
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    Солосептин сенс капли, 0.01%, 10 мл

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 226 ₽
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Инструкция

Показания к применению

Открытоугольная глаукома.
Офтальмогипертензия (в монотерапии или в комбинации с другими препаратами, снижающими внутриглазное давление).

Противопоказания

Гиперчувствительность к бримонидину и другим компонентам препарата.
Детский возраст до 2 лет, низкая масса тела (до 20 кг).
Одновременная терапия ингибиторами моноаминоксидазы (МАО).
Одновременная терапия антидепрессантами, которая влияет на норадренергическую передачу (например, трициклические антидепрессанты и миансерин).
Период кормления грудью.
С осторожностью:
Ортостатическая гипотензия, сердечная недостаточность, цереброваскулярные заболевания, приводящие к недостаточности мозгового кровообращения, почечная недостаточность (клиренс креатинина ниже 40 мл/мин), печеночная недостаточность, депрессия, синдром Рейно, облитерирующий тромбангиит, детский возраст от 2 до 7 лет.

Способ применения и дозы

Местно. В конъюнктивальный мешок пораженного глаза по 1 капле 2 раза в сутки с интервалом между введениями около 12 часов.
Для снижения системной экспозиции препарата сразу после закапывания следует надавить на область слезного мешка у внутреннего угла глаза (закрывая слезную точку) в течение 1 минуты.
Биманокс® можно применять с другими офтальмологическими препаратами с целью снижения внутриглазного давления. Если используют более 2 лекарственных препаратов, то необходимо сделать 15-минутный перерыв между инстилляциями.
Применение Биманокса® не изучали у пациентов с нарушением функции печени или почек; при лечении таких пациентов необходимо соблюдать осторожность.
Избегайте контакта с мягкими контактными линзами. Снимите контактные линзы перед применением и наденьте линзы через 15 минут после применения препарата.
Применение у детей
В трехмесячном исследовании фазы 3 у детей в возрасте от 2 до 7 лет с глаукомой и с недостаточным контролем заболевания при применении бета-блокаторов сообщалось о высокой частоте возникновения сонливости (55%) при применении 0,2% бримонидина в качестве дополнительной терапии. Сонливость была сильно выражена у 8% детей и являлась причиной прекращения лечения в 13% случаев. Частота сонливости снижалась с увеличением возраста и была минимальной у 7-летних детей (25%), но в большей степени определялась массой тела: сонливость чаще отмечалась у детей с массой ≤20 кг (63%) по сравнению с детьми с массой >20 кг (25%).
Безопасность и эффективность Биманокса® у детей младше 2 лет не установлены.
Полная инструкция
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Биманокс гл. капли
Биманокс гл. капли, 0.2%, 5 мл
У продавца: 
нет • На Маркете: 5.0
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Инструкция

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