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Описание

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Мексиприм р-р для в/в введ. и в/м введ., 50 мг/мл, 2 мл, 10 шт.

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У продавца: 
нет • На Маркете: 5.0
(16)
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Количество штук в упаковке, шт.: 10

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Объем, мл: 2

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Коротко о товаре

Артикул Маркета
3123170451
Тип препарата
Назначение
абсцесс брюшной полости, глаукома, дисциркуляторная энцефалопатия, инфаркт, инфаркт миокарда, лечение и профилактика нарушений мозгового кровообращения, нарушение когнитивной функции, нейроциркуляторная дистония, острая интоксикация антипсихотическими средствами, острые нарушения мозгового кровообращения, перитонит, синдром алкогольной абстиненции, синдром вегетативной (нейроциркуляторной) дистонии, тревожные расстройства при невротических и неврозоподобных состояниях, черепно-мозговая травма
Действующее вещество
Возраст
от 18 лет
Инструкция
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\u003Cbr\u003E-Черепно-мозговая травма, последствия черепно-мозговых травм; \u003Cbr\u003E-Дисциркуляторная энцефалопатия; \u003Cbr\u003E-Синдром вегетативной дистонии; \u003Cbr\u003E-Легкие когнитивные расстройства атеросклеротического генеза; \u003Cbr\u003E-Тревожные расстройства при невротических и неврозоподобных состояниях; \u003Cbr\u003E-Острый инфаркт миокарда (с первых суток в составе комплексной терапии); \u003Cbr\u003E-Первичная открытоугольная глаукома различных стадий, в составе комплексной терапии; \u003Cbr\u003E-Купирование абстинентного синдрома при алкоголизме с преобладанием неврозоподобных и вегетативно-сосудистых расстройств; \u003Cbr\u003E-Острая интоксикация антипсихотическими средствами; \u003Cbr\u003E-Острые гнойно-воспалительные процессы брюшной полости (острый некротический панкреатит, перитонит) в составе комплексной терапии.\u003Cbr\u003E"},{"name":"Противопоказания","value":"Повышенная индивидуальная чувствительность к препарату.\u003Cbr\u003EОстрая печеночная и/или почечная недостаточность.\u003Cbr\u003EВ связи с отсутствием данных по эффективности и безопасности - детский возраст, беременность, грудное вскармливание.\u003Cbr\u003E"},{"name":"Состав","value":"Состав на 1 мл:\u003Cbr\u003EДействующее вещество: этилметилгидроксипиридина сукцинат — 50 мг; вспомогательное вещество: вода для инъекций — до 1 мл.\u003Cbr\u003E"},{"name":"Действующее вещество","value":"Этилметилгидроксипиридина сукцинат","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["27144131:28710482"]}}},{"name":"Способ применения и дозы","value":"Внутримышечно или внутривенно (струйно или капельно). При инфузионном способе введения препарат следует разводить в 0,9 % растворе натрия хлорида. Струйно вводят медленно в течение 5-7 мин, капельно - со скоростью 40-60 капель в минуту.\u003Cbr\u003EРежим дозирования подбирается индивидуально. Максимальная суточная доза не должна превышать 1200 мг.\u003Cbr\u003EОстрые нарушения мозгового кровообращения (в составе комплексной терапии): в первые 10-14 дней внутривенно капельно по 200-500 мг 2-4 раза в сутки, затем внутримышечно по 200-250 мг 2-3 раза в сутки в течение 2-х недель.\u003Cbr\u003EЧерепно-мозговая травма, последствия черепно-мозговых травм: в течение 10-15 дней внутривенно капельно по 200-500 мг 2-4 раза в сутки.\u003Cbr\u003EДисциркуляторная энцефалопатия в фазе Декомпенсации: внутривенно струйно или капельно в дозе 200-500 мг 1-2 раза в сутки на протяжении 14 дней; затем внутримышечно по 100-250 мг в сутки в течение последующих 2-х недель.\u003Cbr\u003EКурсовая профилактика дисциркуляторной энцефалопатии: внутримышечно в дозе 200-250 мг 2 раза в сутки в течение 10-14 дней.\u003Cbr\u003EСиндром вегетативной Дистонии, невротические и неврозоподобные состояния: внутримышечно по 50-400 мг в сутки в течение 14 дней.\u003Cbr\u003EЛегкие когнитивные нарушения атеросклеротического генеза (у больных пожилого возраста), тревожные расстройства: внутримышечно в дозе 100-300 мг в сутки в течение 14-30 дней.\u003Cbr\u003EОстрый инфаркт миокарда (с первых суток 6' составе комплексной терапии): внутривенно или внутримышечно в течение 14 суток; препарат применяют на фоне стандартной терапии инфаркта миокарда, включающей нитраты, бета-адреноблокаторы, ингибиторы ангиотензинпревращающего фермента (АПФ), тромболитики, антикоагулянтные и антиагрегантные средства, а также симптоматические средства по показаниям.\u003Cbr\u003EВ первые 5 суток для достижения максимального эффекта препарат вводят внутривенно, в\u003Cbr\u003E \u003Cbr\u003Eпоследующие 9 суток препарат может вводиться внутримышечно.\u003Cbr\u003EВнутривенное введение производят путем капельной инфузии, медленно (во избежание побочных эффектов) в течение 30-90 минут (в 100-150 мл 0,9 % раствора натрия хлорида или 5 % раствора декстрозы (глюкозы)). При необходимости возможно медленное (продолжительностью не менее 5 мин) внутривенное струйное введение препарата.\u003Cbr\u003EВведение препарата (внутривенно или внутримышечно) осуществляют З раза в сутки через каждые 8 часов. Суточная доза составляет 6-9 мг/кг массы тела, разовая доза - 2-3 мг/кг массы тела. Максимальная суточная доза не должна превышать 800 мг, разовая - 250 мг.\u003Cbr\u003EПервичная открытоугольная глаукома различных стадий (в составе комплексной терапии): внутримышечно по 100-300 мг в сутки; 1-3 раза в сутки в течение 14 дней. Абстинентный алкогольный синдром: внутримышечно или внутривенно капельно в дозе 200-500 мг 2-3 раза в сутки в течение 5-7 дней.\u003Cbr\u003EОстрая интоксикация антипсихотическими средствами: внутривенно в дозе 200-500 мг в сутки в течение 7-14 дней.\u003Cbr\u003EОстрые гнойно-воспалительные процессы брюшной полости (острый некротический панкреатит, перитонит): в составе комплексной терапии препарат назначают в первые сутки как в предоперационном, так и в послеоперационном периоде. Вводимые дозы зависят от формы и тяжести заболевания, распространенности процесса, вариантов клинического течения. Отмена препарата должна производиться постепенно только после устойчивого положительного клинико-лабораторного эффекта.\u003Cbr\u003EПри остром отечном (интерстициальном) панкреатите препарат назначают по 200-500 мг З раза в день, внутривенно капельно (в 0,9 % растворе натрия хлорида) и внутримышечно.\u003Cbr\u003EЛегкая степень тяжести некротического панкреатита - по 100-200 мг З раза в день, внутривенно капельно (в 0,90/0 растворе натрия хлорида) и внутримышечно. Средняя степень тяжести - по 200 мг З раза в день, внутривенно капельно (в 0,9 % растворе натрия хлорида). Тяжелое течение - в дозировке 800 мг в первые сутки, при двукратном режиме введения; далее по 200-500 мг 2 раза в день с постепенным снижением суточной дозы. Крайне тяжелое течение - в начальной дозировке 800 мг в сутки до стойкого купирования проявлений панкреатогенного шока, по стабилизации состояния по 300500 мг 2 раза в день внутривенно капельно (в 0,9 % растворе натрия хлорида) с постепенным снижением суточной дозы.\u003Cbr\u003E"},{"name":"Побочные действия","value":"Во избежание возникновения побочных эффектов рекомендуется соблюдать режим дозирования и скорость введения препарата. Частота побочных эффектов определялась в соответствии с классификацией Всемирной организации здравоохранения (ВОЗ): очень часто (\u003E 10 %); часто (⩾ 1 %, но \u003C 10 %); нечасто (⩾ 0,1 %, но \u003C 1 %); редко (⩾ 0,01 %, но \u003C 0,1 %); очень редко (\u003C 0,01 %); частота неизвестна (частота не может быть определена на основе имеющихся данных).\u003Cbr\u003EНарушения со стороны иммунной системы: очень редко анафилактический шок, ангионевротический отек, крапивница.\u003Cbr\u003EПсихические нарушения: очень редко — сонливость.\u003Cbr\u003EНарушения со стороны нервной системы: очень редко — головная боль, головокружение (может быть связано с чрезмерно высокой скоростью введения и носит кратковременный характер).\u003Cbr\u003EНарушения со стороны сосудов: очень редко — понижение артериального давления (АД) повышение АД (может быть связано с чрезмерно высокой скоростью введения и носит кратковременный характер).\u003Cbr\u003EНарушения со стороны Дыхательной системы, органов грудной клетки и средостения: очень редко сухой кашель, першение в горле, дискомфорт в грудной клетке, затруднение дыхания (может быть связано с чрезмерно высокой скоростью введения и носит кратковременный характер).\u003Cbr\u003EЖелудочно-кишечные нарушения: очень редко — сухость во рту, тошнота, ощущение неприятного запаха, металлический привкус во рту.\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей: очень редко — зуд, сыпь, гиперемия.\u003Cbr\u003EОбщие нарушения и реакции в месте введения: очень редко — ощущение тепла.\u003Cbr\u003E"},{"name":"Фармакологическое действие","value":"Антиоксидантный препарат, производное З-оксипиридина; оказывает антигипоксическое, мембранопротекторное, ноотропное, противосудорожное, стресс-протективное, анксиолитическое действие. Препарат повышает резистентность организма к воздействию основных повреждающих факторов, к кислородзависимым патологическим состояниям (шок, гипоксия и ишемия, нарушение мозгового кровообращения, интоксикация алкоголем и антипсихотическими препаратами (нейролептиками)).\u003Cbr\u003EМеханизм действия этилметилгидроксипиридина сукцината обусловлен антиоксидантным, антигипоксантным и мембранопротекторным действием. Препарат уменьшает проявления окислительного стресса, ингибирует перекисное окисление липидов, повышает активность супероксиддисмутазы, повышает соотношение липидбелок, улучшает структуру и функцию мембраны клеток. Препарат модулирует активность мембраносвязанных ферментов (кальцийнезависимой фосфодиэстеразы, аденилатциклазы, ацетилхолинэстеразы),\tрецепторных комплексов\t(бензодиазепинового,\tгаммааминомасляной кислоты (ГАМК), ацетилхолинового), что усиливает их способность связывания с лигандами, способствует сохранению структурно-функциональной организации биомембран, транспорта нейромедиаторов и улучшению синаптической передачи. Препарат повышает содержание в головном мозге дофамина. Вызывает усиление компенсаторной активации аэробного гликолиза и снижение степени угнетения окислительных процессов в цикле Кребса в условиях гипоксии с увеличением содержания аденозинтрифосфата (АТФ) и креатинфосфата, активацию энергосинтезирующих функций митохондрий, стабилизацию клеточных мембран.\u003Cbr\u003EЭтилметилгидроксипиридина сукцинат нормализует метаболические процессы в ишемизированном миокарде и улучшает его функциональное состояние, уменьшает зону некроза, восстанавливает и улучшает электрическую активность и сократимость миокарда, а также увеличивает коронарный кровоток в зоне ишемии, уменьшает последствия реперфузионного синдрома при острой коронарной недостаточности. В условиях коронарной недостаточности увеличивает коллатеральное кровоснабжение ишемизированного миокарда, способствует сохранению целостности кардиомиоцитов и поддержанию их функциональной активности. Эффективно восстанавливает сократимость миокарда при обратимой сердечной дисфункции. Повышает антиангинальную активность нитропрепаратов.\u003Cbr\u003EУлучшает метаболизм и кровоснабжение тканей головного мозга, улучшает микроциркуляцию и реологические свойства крови, уменьшает агрегацию тромбоцитов.\u003Cbr\u003EСтабилизирует мембранные структуры клеток крови (эритроцитов и тромбоцитов). Обладает гиполипидемическим действием, уменьшает содержание общего холестерина и липопротеидов низкой плотности.\u003Cbr\u003EСпособствует сохранению ганглиозных клеток сетчатки и волокон зрительного нерва при прогрессирующей нейропатии, причинами которой являются хроническая ишемия и гипоксия. Улучшает функциональную активность сетчатки и зрительного нерва, увеличивая остроту зрения.\u003Cbr\u003EПрепарат уменьшает ферментативную токсемию и эндогенную интоксикацию при остром панкреатите.\u003Cbr\u003E"},{"name":"Фармакологическая группа","value":"антиоксидантное средство"},{"name":"Форма выпуска","value":"раствор для инъекций"},{"name":"Способ применения/введения","value":"парентеральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["35947170:36763748"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"В защищенном от света месте при температуре не выше 20 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы: сонливость, бессонница.\u003Cbr\u003EЛечение: в связи с низкой токсичностью передозировка маловероятна. Лечение, как правило, не требуется, симптомы исчезают самостоятельно в течение суток. При выраженных проявлениях проводится поддерживающее и симптоматическое лечение.\u003Cbr\u003E"},{"name":"Применение при беременности и кормлении грудью","value":"Применение препарата Мексиприм при беременности и в период грудного вскармливания противопоказано в связи с отсутствием данных по эффективности и безопасности применения препарата в данные периоды."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения необходимо соблюдать осторожность при управлении транспортными средствами и занятии другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"Под влиянием этилметилгидроксипиридина сукцината усиливается действие транквилизирующих, противосудорожных средств, что может потребовать корректировки дозы соответствующих препаратов.\u003Cbr\u003EПрепарат не назначают детям до 18 лет в связи с недостаточной изученностью действия препарата.\u003Cbr\u003E"},{"name":"Взаимодействие","value":"Усиливает действие бензодиазепиновых анксиолитиков, противосудорожных средств\u003Cbr\u003E(карбамазепина), противопаркинсонических средств (леводопа).\u003Cbr\u003EУменьшает токсические эффекты этилового спирта.\u003Cbr\u003E"},{"name":"Регистрационный номер","value":"ЛС-001668"},{"name":"Дата государственной регистрации","value":"10.03.2020"},{"name":"Владелец регистрационного удостоверения","value":"Нижфарм","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["34324371:35649313","7893318:13891801"]}}},{"name":"Изготовитель","value":"Полисан"},{"name":"Фасовщик","value":"Полисан"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Мексиприм","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["17796364:18033595"]}}},{"name":"Срок годности","value":"36 мес."}]}},"fullSpecsGrouped":{"1702518087015253987":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"головной мозг, нервная система"},{"name":"Назначение","value":"абсцесс брюшной полости, глаукома, дисциркуляторная энцефалопатия, инфаркт, инфаркт миокарда, лечение и профилактика нарушений мозгового кровообращения, нарушение когнитивной функции, нейроциркуляторная дистония, острая интоксикация антипсихотическими средствами, острые нарушения мозгового кровообращения, перитонит, синдром алкогольной абстиненции, синдром вегетативной (нейроциркуляторной) дистонии, тревожные расстройства при невротических и неврозоподобных состояниях, черепно-мозговая травма"},{"name":"Показания к применению","value":"- Острые нарушения мозгового кровообращения (в составе комплексной терапии); \u003Cbr\u003E-Черепно-мозговая травма, последствия черепно-мозговых травм; \u003Cbr\u003E-Дисциркуляторная энцефалопатия; \u003Cbr\u003E-Синдром вегетативной дистонии; \u003Cbr\u003E-Легкие когнитивные расстройства атеросклеротического генеза; \u003Cbr\u003E-Тревожные расстройства при невротических и неврозоподобных состояниях; \u003Cbr\u003E-Острый инфаркт миокарда (с первых суток в составе комплексной терапии); \u003Cbr\u003E-Первичная открытоугольная глаукома различных стадий, в составе комплексной терапии; \u003Cbr\u003E-Купирование абстинентного синдрома при алкоголизме с преобладанием неврозоподобных и вегетативно-сосудистых расстройств; \u003Cbr\u003E-Острая интоксикация антипсихотическими средствами; \u003Cbr\u003E-Острые гнойно-воспалительные процессы брюшной полости (острый некротический панкреатит, перитонит) в составе комплексной терапии.\u003Cbr\u003E"},{"name":"Противопоказания","value":"Повышенная индивидуальная чувствительность к препарату.\u003Cbr\u003EОстрая печеночная и/или почечная недостаточность.\u003Cbr\u003EВ связи с отсутствием данных по эффективности и безопасности - детский возраст, беременность, грудное вскармливание.\u003Cbr\u003E"},{"name":"Состав","value":"Состав на 1 мл:\u003Cbr\u003EДействующее вещество: этилметилгидроксипиридина сукцинат — 50 мг; вспомогательное вещество: вода для инъекций — до 1 мл.\u003Cbr\u003E"},{"name":"Действующее вещество","value":"Этилметилгидроксипиридина сукцинат"},{"name":"Способ применения и дозы","value":"Внутримышечно или внутривенно (струйно или капельно). При инфузионном способе введения препарат следует разводить в 0,9 % растворе натрия хлорида. Струйно вводят медленно в течение 5-7 мин, капельно - со скоростью 40-60 капель в минуту.\u003Cbr\u003EРежим дозирования подбирается индивидуально. Максимальная суточная доза не должна превышать 1200 мг.\u003Cbr\u003EОстрые нарушения мозгового кровообращения (в составе комплексной терапии): в первые 10-14 дней внутривенно капельно по 200-500 мг 2-4 раза в сутки, затем внутримышечно по 200-250 мг 2-3 раза в сутки в течение 2-х недель.\u003Cbr\u003EЧерепно-мозговая травма, последствия черепно-мозговых травм: в течение 10-15 дней внутривенно капельно по 200-500 мг 2-4 раза в сутки.\u003Cbr\u003EДисциркуляторная энцефалопатия в фазе Декомпенсации: внутривенно струйно или капельно в дозе 200-500 мг 1-2 раза в сутки на протяжении 14 дней; затем внутримышечно по 100-250 мг в сутки в течение последующих 2-х недель.\u003Cbr\u003EКурсовая профилактика дисциркуляторной энцефалопатии: внутримышечно в дозе 200-250 мг 2 раза в сутки в течение 10-14 дней.\u003Cbr\u003EСиндром вегетативной Дистонии, невротические и неврозоподобные состояния: внутримышечно по 50-400 мг в сутки в течение 14 дней.\u003Cbr\u003EЛегкие когнитивные нарушения атеросклеротического генеза (у больных пожилого возраста), тревожные расстройства: внутримышечно в дозе 100-300 мг в сутки в течение 14-30 дней.\u003Cbr\u003EОстрый инфаркт миокарда (с первых суток 6' составе комплексной терапии): внутривенно или внутримышечно в течение 14 суток; препарат применяют на фоне стандартной терапии инфаркта миокарда, включающей нитраты, бета-адреноблокаторы, ингибиторы ангиотензинпревращающего фермента (АПФ), тромболитики, антикоагулянтные и антиагрегантные средства, а также симптоматические средства по показаниям.\u003Cbr\u003EВ первые 5 суток для достижения максимального эффекта препарат вводят внутривенно, в\u003Cbr\u003E \u003Cbr\u003Eпоследующие 9 суток препарат может вводиться внутримышечно.\u003Cbr\u003EВнутривенное введение производят путем капельной инфузии, медленно (во избежание побочных эффектов) в течение 30-90 минут (в 100-150 мл 0,9 % раствора натрия хлорида или 5 % раствора декстрозы (глюкозы)). При необходимости возможно медленное (продолжительностью не менее 5 мин) внутривенное струйное введение препарата.\u003Cbr\u003EВведение препарата (внутривенно или внутримышечно) осуществляют З раза в сутки через каждые 8 часов. Суточная доза составляет 6-9 мг/кг массы тела, разовая доза - 2-3 мг/кг массы тела. Максимальная суточная доза не должна превышать 800 мг, разовая - 250 мг.\u003Cbr\u003EПервичная открытоугольная глаукома различных стадий (в составе комплексной терапии): внутримышечно по 100-300 мг в сутки; 1-3 раза в сутки в течение 14 дней. Абстинентный алкогольный синдром: внутримышечно или внутривенно капельно в дозе 200-500 мг 2-3 раза в сутки в течение 5-7 дней.\u003Cbr\u003EОстрая интоксикация антипсихотическими средствами: внутривенно в дозе 200-500 мг в сутки в течение 7-14 дней.\u003Cbr\u003EОстрые гнойно-воспалительные процессы брюшной полости (острый некротический панкреатит, перитонит): в составе комплексной терапии препарат назначают в первые сутки как в предоперационном, так и в послеоперационном периоде. Вводимые дозы зависят от формы и тяжести заболевания, распространенности процесса, вариантов клинического течения. Отмена препарата должна производиться постепенно только после устойчивого положительного клинико-лабораторного эффекта.\u003Cbr\u003EПри остром отечном (интерстициальном) панкреатите препарат назначают по 200-500 мг З раза в день, внутривенно капельно (в 0,9 % растворе натрия хлорида) и внутримышечно.\u003Cbr\u003EЛегкая степень тяжести некротического панкреатита - по 100-200 мг З раза в день, внутривенно капельно (в 0,90/0 растворе натрия хлорида) и внутримышечно. Средняя степень тяжести - по 200 мг З раза в день, внутривенно капельно (в 0,9 % растворе натрия хлорида). Тяжелое течение - в дозировке 800 мг в первые сутки, при двукратном режиме введения; далее по 200-500 мг 2 раза в день с постепенным снижением суточной дозы. Крайне тяжелое течение - в начальной дозировке 800 мг в сутки до стойкого купирования проявлений панкреатогенного шока, по стабилизации состояния по 300500 мг 2 раза в день внутривенно капельно (в 0,9 % растворе натрия хлорида) с постепенным снижением суточной дозы.\u003Cbr\u003E"},{"name":"Побочные действия","value":"Во избежание возникновения побочных эффектов рекомендуется соблюдать режим дозирования и скорость введения препарата. Частота побочных эффектов определялась в соответствии с классификацией Всемирной организации здравоохранения (ВОЗ): очень часто (\u003E 10 %); часто (⩾ 1 %, но \u003C 10 %); нечасто (⩾ 0,1 %, но \u003C 1 %); редко (⩾ 0,01 %, но \u003C 0,1 %); очень редко (\u003C 0,01 %); частота неизвестна (частота не может быть определена на основе имеющихся данных).\u003Cbr\u003EНарушения со стороны иммунной системы: очень редко анафилактический шок, ангионевротический отек, крапивница.\u003Cbr\u003EПсихические нарушения: очень редко — сонливость.\u003Cbr\u003EНарушения со стороны нервной системы: очень редко — головная боль, головокружение (может быть связано с чрезмерно высокой скоростью введения и носит кратковременный характер).\u003Cbr\u003EНарушения со стороны сосудов: очень редко — понижение артериального давления (АД) повышение АД (может быть связано с чрезмерно высокой скоростью введения и носит кратковременный характер).\u003Cbr\u003EНарушения со стороны Дыхательной системы, органов грудной клетки и средостения: очень редко сухой кашель, першение в горле, дискомфорт в грудной клетке, затруднение дыхания (может быть связано с чрезмерно высокой скоростью введения и носит кратковременный характер).\u003Cbr\u003EЖелудочно-кишечные нарушения: очень редко — сухость во рту, тошнота, ощущение неприятного запаха, металлический привкус во рту.\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей: очень редко — зуд, сыпь, гиперемия.\u003Cbr\u003EОбщие нарушения и реакции в месте введения: очень редко — ощущение тепла.\u003Cbr\u003E"},{"name":"Фармакологическое действие","value":"Антиоксидантный препарат, производное З-оксипиридина; оказывает антигипоксическое, мембранопротекторное, ноотропное, противосудорожное, стресс-протективное, анксиолитическое действие. Препарат повышает резистентность организма к воздействию основных повреждающих факторов, к кислородзависимым патологическим состояниям (шок, гипоксия и ишемия, нарушение мозгового кровообращения, интоксикация алкоголем и антипсихотическими препаратами (нейролептиками)).\u003Cbr\u003EМеханизм действия этилметилгидроксипиридина сукцината обусловлен антиоксидантным, антигипоксантным и мембранопротекторным действием. Препарат уменьшает проявления окислительного стресса, ингибирует перекисное окисление липидов, повышает активность супероксиддисмутазы, повышает соотношение липидбелок, улучшает структуру и функцию мембраны клеток. Препарат модулирует активность мембраносвязанных ферментов (кальцийнезависимой фосфодиэстеразы, аденилатциклазы, ацетилхолинэстеразы),\tрецепторных комплексов\t(бензодиазепинового,\tгаммааминомасляной кислоты (ГАМК), ацетилхолинового), что усиливает их способность связывания с лигандами, способствует сохранению структурно-функциональной организации биомембран, транспорта нейромедиаторов и улучшению синаптической передачи. Препарат повышает содержание в головном мозге дофамина. Вызывает усиление компенсаторной активации аэробного гликолиза и снижение степени угнетения окислительных процессов в цикле Кребса в условиях гипоксии с увеличением содержания аденозинтрифосфата (АТФ) и креатинфосфата, активацию энергосинтезирующих функций митохондрий, стабилизацию клеточных мембран.\u003Cbr\u003EЭтилметилгидроксипиридина сукцинат нормализует метаболические процессы в ишемизированном миокарде и улучшает его функциональное состояние, уменьшает зону некроза, восстанавливает и улучшает электрическую активность и сократимость миокарда, а также увеличивает коронарный кровоток в зоне ишемии, уменьшает последствия реперфузионного синдрома при острой коронарной недостаточности. В условиях коронарной недостаточности увеличивает коллатеральное кровоснабжение ишемизированного миокарда, способствует сохранению целостности кардиомиоцитов и поддержанию их функциональной активности. Эффективно восстанавливает сократимость миокарда при обратимой сердечной дисфункции. Повышает антиангинальную активность нитропрепаратов.\u003Cbr\u003EУлучшает метаболизм и кровоснабжение тканей головного мозга, улучшает микроциркуляцию и реологические свойства крови, уменьшает агрегацию тромбоцитов.\u003Cbr\u003EСтабилизирует мембранные структуры клеток крови (эритроцитов и тромбоцитов). Обладает гиполипидемическим действием, уменьшает содержание общего холестерина и липопротеидов низкой плотности.\u003Cbr\u003EСпособствует сохранению ганглиозных клеток сетчатки и волокон зрительного нерва при прогрессирующей нейропатии, причинами которой являются хроническая ишемия и гипоксия. Улучшает функциональную активность сетчатки и зрительного нерва, увеличивая остроту зрения.\u003Cbr\u003EПрепарат уменьшает ферментативную токсемию и эндогенную интоксикацию при остром панкреатите.\u003Cbr\u003E"},{"name":"Фармакологическая группа","value":"антиоксидантное средство"},{"name":"Форма выпуска","value":"раствор для инъекций"},{"name":"Способ применения/введения","value":"парентеральный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"В защищенном от света месте при температуре не выше 20 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы: сонливость, бессонница.\u003Cbr\u003EЛечение: в связи с низкой токсичностью передозировка маловероятна. Лечение, как правило, не требуется, симптомы исчезают самостоятельно в течение суток. При выраженных проявлениях проводится поддерживающее и симптоматическое лечение.\u003Cbr\u003E"},{"name":"Применение при беременности и кормлении грудью","value":"Применение препарата Мексиприм при беременности и в период грудного вскармливания противопоказано в связи с отсутствием данных по эффективности и безопасности применения препарата в данные периоды."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения необходимо соблюдать осторожность при управлении транспортными средствами и занятии другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"Под влиянием этилметилгидроксипиридина сукцината усиливается действие транквилизирующих, противосудорожных средств, что может потребовать корректировки дозы соответствующих препаратов.\u003Cbr\u003EПрепарат не назначают детям до 18 лет в связи с недостаточной изученностью действия препарата.\u003Cbr\u003E"},{"name":"Взаимодействие","value":"Усиливает действие бензодиазепиновых анксиолитиков, противосудорожных средств\u003Cbr\u003E(карбамазепина), противопаркинсонических средств (леводопа).\u003Cbr\u003EУменьшает токсические эффекты этилового спирта.\u003Cbr\u003E"},{"name":"Регистрационный номер","value":"ЛС-001668"},{"name":"Дата государственной регистрации","value":"10.03.2020"},{"name":"Владелец регистрационного удостоверения","value":"Нижфарм"},{"name":"Изготовитель","value":"Полисан"},{"name":"Фасовщик","value":"Полисан"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Мексиприм"},{"name":"Срок годности","value":"36 мес."}]}],"transitionId":"tr_14590128446474314103"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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    Цена 218 ₽
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  • Мексидол р-р для в/в и в/м введ. амп., 50 мг/мл, 2 мл, 20 шт.
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    Мексидол р-р для в/в и в/м введ. амп., 50 мг/мл, 2 мл, 20 шт.

    Рейтинг товара: 4.8 из 5
    на основе 11 оценок
    Цена 1 013 ₽
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  • Нейрокс р-р для в/в введ. введ. и в/м введ., 50 мг/мл, 5 мл, 5 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-bik3hvvi4g/toggleWishlist":{"skuId":"186488335","productId":1404748424,"offerId":"OwELWAJ6e8ceyNkLLL4gOQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQusaO1/isluUfEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIiIXrnQUQj6z2WBig6pAHIO3ZwQc=","sign":"lmLphY9aiYcNTntL4rV086E6tkX6dJCHxULogF5Shlc="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-bik3hvvi4g/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Нейрокс р-р для в/в введ. введ. и в/м введ., 50 мг/мл, 5 мл, 5 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 373 ₽
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  • Мексиприм р-р д/в-в и в/м введ. амп., 50 мг/мл, 2 мл, 10 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-pcgnx825tja/toggleWishlist":{"skuId":"101517907744","productId":647860215,"offerId":"8NBNB3qQM0P2bExJXBT3cg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQusaO1/isluUfEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI95/2tAIQoK7Bl/oCGMrc0Acg7dnBBw==","sign":"v5m9dFuIUc5bHioGphuWQur4keQNsRRN13Jhs6mSQnQ="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-pcgnx825tja/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Мексиприм р-р д/в-в и в/м введ. амп., 50 мг/мл, 2 мл, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 436 ₽
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  • Мексидол таб. п/о плен., 125 мг, 30 шт.
    –17 %
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    Мексидол таб. п/о плен., 125 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 62 оценки
    Цена 293 ₽ вместо 355
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  • Нейромексол р-р для в/в и в/м введ., 50 мг/мл, 2 мл, 10 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-mwur8pb9wml/toggleWishlist":{"skuId":"101811668827","productId":1768324960,"offerId":"wTyUqdcpQgGusDlks1MkTw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQusaO1/isluUfEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI4P6ZywYQ247Lo/sCGMPe0Acg7dnBBw==","sign":"KUsTiwqbYhZ7X01+ZLeoBeYrYK/CQfI7xiFdVGt3/zM="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-mwur8pb9wml/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Нейромексол р-р для в/в и в/м введ., 50 мг/мл, 2 мл, 10 шт.

    Рейтинг товара: 3 из 5
    на основе 2 оценки
    Цена 320 ₽
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  • Мексикор р-р для в/в и в/м введ., 50 мг/мл, 5 мл, 5 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-03ty0hsd2wfw/toggleWishlist":{"skuId":"101635513732","productId":1733347159,"offerId":"3lLSRSc7H2AYpQ_SQDrDGQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQusaO1/isluUfEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI147DugYQhLvLz/oCGNPh0Acg7dnBBw==","sign":"LveTq2pDoIAstQVvWhej+SUYlzSmAdtNB4T4WqQEpKM="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-03ty0hsd2wfw/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Мексикор р-р для в/в и в/м введ., 50 мг/мл, 5 мл, 5 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 327 ₽
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  • Церетон р-р для в/в и в/м введ., 250 мг/мл, 4 мл, 3 шт.
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    Церетон р-р для в/в и в/м введ., 250 мг/мл, 4 мл, 3 шт.

    Рейтинг товара: 4.7 из 5
    на основе 3 оценки
    Цена 443 ₽
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  • Аксамон р-р для в/м введ. и п/к введ., 15 мг/мл, 1 мл, 10 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ieimxryj5eq/toggleWishlist":{"skuId":"186942960","productId":1404748484,"offerId":"tc8Wc84IaNJ4fqRWzvpSDQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQusaO1/isluUfEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIxIXrnQUQ8IuSWRjp3dAHIO3ZwQc=","sign":"/9s7377ueDzc5EYGdf5o/OwdMLqzL9NsKsOoKunpyXs="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ieimxryj5eq/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Аксамон р-р для в/м введ. и п/к введ., 15 мг/мл, 1 мл, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 1 949 ₽
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  • Пикамилон р-р д/в-в и в/м введ. амп., 100 мг/мл, 2 мл, 10 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-yy5qdftij1b/toggleWishlist":{"skuId":"101670108998","productId":647865101,"offerId":"bEu06mMAwinuk9O7vTGLUA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQusaO1/isluUfEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIjcb2tAIQxv6K4PoCGK7C2Qcg7dnBBw==","sign":"SztOu5/wak4V8HcLOWQQzIKeuxcdk0rVKhn37JWVRIo="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-yy5qdftij1b/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Пикамилон р-р д/в-в и в/м введ. амп., 100 мг/мл, 2 мл, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 338 ₽
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  • Мексифин р-р для в/в введ. и в/м введ., 50 мг/мл, 2 мл, 10 шт.
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    Мексифин р-р для в/в введ. и в/м введ., 50 мг/мл, 2 мл, 10 шт.

    Рейтинг товара: 3.4 из 5
    на основе 8 оценок
    Цена 315 ₽
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  • Армадин 50 р-р для в/в и в/м введ., 50 мг/мл, 5 мл, 0.5 г, 5 шт.
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    Армадин 50 р-р для в/в и в/м введ., 50 мг/мл, 5 мл, 0.5 г, 5 шт.

    Рейтинг товара: 3 из 5
    на основе 2 оценки
    Цена 446 ₽
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Инструкция

Показания к применению

- Острые нарушения мозгового кровообращения (в составе комплексной терапии);
-Черепно-мозговая травма, последствия черепно-мозговых травм;
-Дисциркуляторная энцефалопатия;
-Синдром вегетативной дистонии;
-Легкие когнитивные расстройства атеросклеротического генеза;
-Тревожные расстройства при невротических и неврозоподобных состояниях;
-Острый инфаркт миокарда (с первых суток в составе комплексной терапии);
-Первичная открытоугольная глаукома различных стадий, в составе комплексной терапии;
-Купирование абстинентного синдрома при алкоголизме с преобладанием неврозоподобных и вегетативно-сосудистых расстройств;
-Острая интоксикация антипсихотическими средствами;
-Острые гнойно-воспалительные процессы брюшной полости (острый некротический панкреатит, перитонит) в составе комплексной терапии.

Противопоказания

Повышенная индивидуальная чувствительность к препарату.
Острая печеночная и/или почечная недостаточность.
В связи с отсутствием данных по эффективности и безопасности - детский возраст, беременность, грудное вскармливание.

Способ применения и дозы

Внутримышечно или внутривенно (струйно или капельно). При инфузионном способе введения препарат следует разводить в 0,9 % растворе натрия хлорида. Струйно вводят медленно в течение 5-7 мин, капельно - со скоростью 40-60 капель в минуту.
Режим дозирования подбирается индивидуально. Максимальная суточная доза не должна превышать 1200 мг.
Острые нарушения мозгового кровообращения (в составе комплексной терапии): в первые 10-14 дней внутривенно капельно по 200-500 мг 2-4 раза в сутки, затем внутримышечно по 200-250 мг 2-3 раза в сутки в течение 2-х недель.
Черепно-мозговая травма, последствия черепно-мозговых травм: в течение 10-15 дней внутривенно капельно по 200-500 мг 2-4 раза в сутки.
Дисциркуляторная энцефалопатия в фазе Декомпенсации: внутривенно струйно или капельно в дозе 200-500 мг 1-2 раза в сутки на протяжении 14 дней; затем внутримышечно по 100-250 мг в сутки в течение последующих 2-х недель.
Курсовая профилактика дисциркуляторной энцефалопатии: внутримышечно в дозе 200-250 мг 2 раза в сутки в течение 10-14 дней.
Синдром вегетативной Дистонии, невротические и неврозоподобные состояния: внутримышечно по 50-400 мг в сутки в течение 14 дней.
Легкие когнитивные нарушения атеросклеротического генеза (у больных пожилого возраста), тревожные расстройства: внутримышечно в дозе 100-300 мг в сутки в течение 14-30 дней.
Острый инфаркт миокарда (с первых суток 6' составе комплексной терапии): внутривенно или внутримышечно в течение 14 суток; препарат применяют на фоне стандартной терапии инфаркта миокарда, включающей нитраты, бета-адреноблокаторы, ингибиторы ангиотензинпревращающего фермента (АПФ), тромболитики, антикоагулянтные и антиагрегантные средства, а также симптоматические средства по показаниям.
В первые 5 суток для достижения максимального эффекта препарат вводят внутривенно, в

последующие 9 суток препарат может вводиться внутримышечно.
Внутривенное введение производят путем капельной инфузии, медленно (во избежание побочных эффектов) в течение 30-90 минут (в 100-150 мл 0,9 % раствора натрия хлорида или 5 % раствора декстрозы (глюкозы)). При необходимости возможно медленное (продолжительностью не менее 5 мин) внутривенное струйное введение препарата.
Введение препарата (внутривенно или внутримышечно) осуществляют З раза в сутки через каждые 8 часов. Суточная доза составляет 6-9 мг/кг массы тела, разовая доза - 2-3 мг/кг массы тела. Максимальная суточная доза не должна превышать 800 мг, разовая - 250 мг.
Первичная открытоугольная глаукома различных стадий (в составе комплексной терапии): внутримышечно по 100-300 мг в сутки; 1-3 раза в сутки в течение 14 дней. Абстинентный алкогольный синдром: внутримышечно или внутривенно капельно в дозе 200-500 мг 2-3 раза в сутки в течение 5-7 дней.
Острая интоксикация антипсихотическими средствами: внутривенно в дозе 200-500 мг в сутки в течение 7-14 дней.
Острые гнойно-воспалительные процессы брюшной полости (острый некротический панкреатит, перитонит): в составе комплексной терапии препарат назначают в первые сутки как в предоперационном, так и в послеоперационном периоде. Вводимые дозы зависят от формы и тяжести заболевания, распространенности процесса, вариантов клинического течения. Отмена препарата должна производиться постепенно только после устойчивого положительного клинико-лабораторного эффекта.
При остром отечном (интерстициальном) панкреатите препарат назначают по 200-500 мг З раза в день, внутривенно капельно (в 0,9 % растворе натрия хлорида) и внутримышечно.
Легкая степень тяжести некротического панкреатита - по 100-200 мг З раза в день, внутривенно капельно (в 0,90/0 растворе натрия хлорида) и внутримышечно. Средняя степень тяжести - по 200 мг З раза в день, внутривенно капельно (в 0,9 % растворе натрия хлорида). Тяжелое течение - в дозировке 800 мг в первые сутки, при двукратном режиме введения; далее по 200-500 мг 2 раза в день с постепенным снижением суточной дозы. Крайне тяжелое течение - в начальной дозировке 800 мг в сутки до стойкого купирования проявлений панкреатогенного шока, по стабилизации состояния по 300500 мг 2 раза в день внутривенно капельно (в 0,9 % растворе натрия хлорида) с постепенным снижением суточной дозы.
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Мексиприм р-р для в/в введ. и в/м введ.
Мексиприм р-р для в/в введ. и в/м введ., 50 мг/мл, 2 мл, 10 шт.
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