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Описание

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Церукал таб., 10 мг, 50 шт.

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5.0
(8)
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Коротко о товаре

Артикул Маркета
3123168705
Тип препарата
Назначение
Действующее вещество
Возраст
от 13.33 лет
Инструкция
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\u003Cbr\u003E- желудочно-кишечное кровотечение, механическая кишечная непроходимость или перфорация стенки желудка и кишечника, состояния, при которых стимуляция перистальтики желудочно-кишечного тракта представляет риск; \u003Cbr\u003E- подтвержденная или подозреваемая феохромоцитома в связи с риском развития тяжелой артериальной гипертензии; \u003Cbr\u003E- поздняя дискинезия, которая развилась после лечения нейролептиками или метоклопрамидом в анамнезе; \u003Cbr\u003E- эпилепсия (увеличение частоты и тяжести припадков); \u003Cbr\u003E- болезнь Паркинсона; \u003Cbr\u003E- одновременное применение с леводопой и агонистами дофаминовых рецепторов; \u003Cbr\u003E- метгемоглобинемия вследствие приема метоклопрамида или дефицита никотинамидадениндинуклеотида (НАДИ) цитохрома-b5 в анамнезе; \u003Cbr\u003E- пролактинома или пролактинзависимая опухоль; \u003Cbr\u003E- дефицит лактазы, непереносимость лактозы, глюкозо-галактозная мальабсорбция; \u003Cbr\u003E- детский возраст до 15 лет; \u003Cbr\u003E- период грудного вскармливания."},{"name":"Состав","value":"В 1 таблетке содержится: активное вещество метоклопрамида гидрохлорида моногидрат 10,54 мг (в пересчете на метоклопрамида гидрохлорид 10,00 мг);\u003Cbr\u003Eвспомогательные вещества: крахмал картофельный 36,75 мг, лактозы моногидрат 76,65 мг, желатин 2,16 мг, кремния диоксид 2,60 мг, магния стеарат 1,30 мг.\u003Cbr\u003E"},{"name":"Действующее вещество","value":"Метоклопрамид","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["27144131:28708918"]}}},{"name":"Способ применения и дозы","value":"Внутрь. \u003Cbr\u003EВзрослые и дети старше 15 лет с массой тела более 60 кг\u003Cbr\u003EРекомендуемая доза I таблетка (10 мг) до трех раз в сутки. \u003Cbr\u003EМаксимальная рекомендуемая суточная доза составляет 30 мг или 0,5 мг/кг массы тела. \u003Cbr\u003EДети старше 15 лет с массой тела менее 60 кг\u003Cbr\u003EРекомендуемая доза составляет 1/2 таблетки (5 мг) 1-3 раза в сутки. Максимальная рекомендуемая суточная доза составляет 0.5 мг/кг/сут. \u003Cbr\u003EВо избежание передозировки необходимо соблюдать минимальный интервал между приемами 6 ч, даже в случае рвоты. Максимальный срок лечения составляет 5 дней. \u003Cbr\u003EПожилые пациенты\u003Cbr\u003EУ пожилых пациентов может потребоваться снижение дозы в зависимости от показателей функции почек и печени и общего состояния. \u003Cbr\u003EПочечная недостаточность\u003Cbr\u003EУ пациентов с терминальной стадией почечной недостаточности (клиренс креатинина менее 15 мл/мин) суточная доза должна быть снижена на 75%.\u003Cbr\u003EУ пациентов с почечной недостаточностью средней или тяжелой степени тяжести (КК 15-60 мл/мин) доза должна быть снижена на 50%.\u003Cbr\u003EНарушение функции печени\u003Cbr\u003EУ пациентов с печеночной недостаточностью тяжелой степени тяжести доза должна быть снижена на 50%. \u003Cbr\u003E"},{"name":"Побочные действия","value":"Частота побочных реакций классифицирована следующим образом: очень часто (≥ 1/10), часто (≥ 1/100 - \u003C 1/10). нечасто (≥ 1/1000 - \u003C 1/100), редко (≥ 1/10000 - \u003C 1/1000), очень редко (\u003C 1/10000). частота неизвестна (не может быть оценена на основании имеющихся данных). \u003Cbr\u003EСо стороны крови и лимфатической системы: частота неизвестна метгемоглобинемия, вероятно связанная с дефицитом фермента НАДН-зависимой цитохром-b5 редуктазы, особенно у новорожденных, сульфгемоглобинемия (чаще всего при одновременном применении высоких доз серосодержащих препаратов), лейкопения, нейтропения, агранулоцитоз. \u003Cbr\u003EСо стороны сердца: нечасто брадикардия; частота неизвестна остановка сердца, которая может быть вызвана брадикардией, атриовентрикулярная блокада, блокада синусного узла, удлинение интервала QT на электрокардиограмме, аритмия типа \"пируэт\".\u003Cbr\u003EСо стороны сосудов: часто - понижение артериального давления; частота неизвестна - кардиогенный шок, острое повышение артериального давления у пациентов с феохромоцитомой. \u003Cbr\u003EСо стороны эндокринной системы*: нечасто - аменорея, гиперпролактинемия; редко - галакторея; частота неизвестна -гинекомастия. \u003Cbr\u003EЭндокринные нарушения во время продолжительного лечения связаны с гиперпролактинемией (аменорея, галакторея. гинекомастия). \u003Cbr\u003EСо стороны желудочно-кишечного тракта: часто - тошнота, диарея, запор. \u003Cbr\u003EСо стороны почек и мочевыводящих путей: частота неизвестна - полиурия, недержание мочи. \u003Cbr\u003EСо стороны половых органов и молочной железы: неизвестная частота сексуальная дисфункция, приапизм. \u003Cbr\u003EСо стороны иммунной системы: нечасто - гиперчувствительность; частота неизвестна - анафилактические реакции (в том числе анафилактический шок), аллергические реакции (крапивница, макулопапулезная сыпь). \u003Cbr\u003EСо стороны нервной системы: очень часто - сонливость; часто - астения, экстрапирамидные нарушения (особенно у детей и молодых пациентов и/или при превышении рекомендованных доз препарата, даже после однократного введения), паркинсонизм, акатизия: нечасто - дистония, дискинезия, нарушение сознания: редко - судороги, в особенности у пациентов с эпилепсией; частота неизвестна - поздняя дискинезия, иногда персистирующая, во время или после длительного лечения, в особенности у пожилых пациентов, нейролептический злокачественный синдром. \u003Cbr\u003EНарушение психики: часто - депрессия; нечасто - галлюцинации; редко спутанность сознания. \u003Cbr\u003EНежелательные реакции, наиболее часто встречающиеся при применении высоких доз препарата\u003Cbr\u003E- Экстрапирамидные симптомы: острая дистония и дискинезия, синдром паркинсонизма, акатизия развивались даже после применения однократной дозы препарата, особенно у детей и молодых пациентов (см. раздел \"Особые указания\").\u003Cbr\u003E- Сонливость, снижение уровня сознания, спутанность сознания, галлюцинации. \u003Cbr\u003E"},{"name":"Фармакологическое действие","value":"Противорвотное средство, является специфическим блокатором дофаминовых (D2) и серотониновых рецепторов. Механизм действия основан как на центральном, так и на периферическом воздействии метоклопрамида. Противорвотное действие связано с блокадой дофаминовых рецепторов головного мозга, что обуславливает повышение порога раздражения рвотного центра. Оказывает противорвотное действие, устраняет тошноту и икоту. Снижает двигательную активность пищевода, повышает тонус нижнего сфинктера пищевода, ускоряет опорожнение желудка, а также ускоряет продвижение пищи по тонкой кишке, не вызывая диарею. Нормализует выделение желчи, уменьшает спазм сфинктера Одди, не изменяет его статус, устраняет дискинезию желчного пузыря. Стимулирует секрецию пролактина."},{"name":"Фармакологическая группа","value":"противорвотные средства"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 13.33 лет"},{"name":"Условия хранения","value":"Хранить в защищенном от света месте, при температуре не выше 25°С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы\u003Cbr\u003EЭкстрапирамидные нарушения, сонливость, снижение уровня сознания, спутанность сознания, галлюцинации, раздражительность, головокружение, брадикардия, изменения артериального давления, остановка сердца и дыхания, боль в животе. \u003Cbr\u003EЛечение\u003Cbr\u003EВ случае развития экстрапирамидных симптомов, вызванных передозировкой или но другой причине, лечение носит исключительно симптоматический характер (бензодиазепииы у детей и/или антихолииергические противопаркинсонические препараты у взрослых). \u003Cbr\u003EТребуется симптоматическое лечение и постоянный контроль сердечной и дыхательной функций в зависимости от клинического состояния пациента. \u003Cbr\u003EСпецифического антидота не существует. \u003Cbr\u003E"},{"name":"Применение при беременности и кормлении грудью","value":"Беременность\u003Cbr\u003EМногочисленные данные, полученные о применении у беременных женщин (более 1000 описанных случаев) указывают на отсутствие фетотоксичности и способности вызывать пороки развития у плода. Мстоклопрамид можно применять во время беременности (I-II триместры) только если потенциальная польза для матери превышает потенциальный риск для плода. В связи с фармакологическими особенностями (подобно другим нейролептикам), при применении метоклопрамида в конце беременности нельзя исключить вероятность развития экстрапирамидных симптомов у новорожденного. Метоклопрамид не следует применять в конце беременности (во время III триместра). При применении метоклопрамида следует следить за состоянием новорожденного. \u003Cbr\u003EПериод грудного вскармливания\u003Cbr\u003EМетоклопрамид в небольшом количестве выделяется с грудным молоком. Нельзя исключать возможность развития\u003Cbr\u003Eпобочных реакций у ребенка. Применение метоклопрамида в период грудного вскармливания не рекомендуется. При необходимости применения препарата в период лактации следует прекратить грудное вскармливание. \u003Cbr\u003E"},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Следует соблюдать осторожность при управлении транспортными средствами и другими механизмами, т.к. прием препарата может вызывать сонливость и дискинезию."},{"name":"Особые указания","value":"С осторожностью: \u003Cbr\u003EПри применении у пожилых пациентов; у пациентов с нарушением сердечной проводимости (включая удлинение интервала QT), нарушением водноэлектролитного баланса, брадикардией, принимающих другие препараты, удлиняющие интервал QT, артериальной гипертензией; у пациентов с сопутствующими неврологическими заболеваниями, депрессией (в анамнезе); при почечной недостаточности средней и тяжелой степени тяжести (КК 15-60 мл/мин); при печеночной недостаточности тяжелой степени тяжести; при беременности.\u003Cbr\u003EСледует соблюдать осторожность при применении препарата Церукал у пожилых пациентов. \u003Cbr\u003EСо стороны нервной системы возможны экстрапирамидные нарушения, особенно у детей и молодых пациентов и/или при применении высоких доз, развивающиеся, как правило, в начале лечения или после однократного применения. Применение препарата Церукал необходимо незамедлительно прекратить в случае появления экстрапирамидных симптомов. Реакции полностью обратимы после прекращения лечения, однако могут потребовать симптоматической терапии (беизодиазепины у детей и/или антихолинергические противопаркинсонические препараты у взрослых). \u003Cbr\u003EВо избежание передозировки препарата Церукал необходимо соблюдать минимальный интервал между приемами 6 ч. даже в случае рвоты. \u003Cbr\u003EДлительное лечение препаратом Церукал может привести к развитию поздней дискинезии, потенциально необратимой, особенно у пожилых пациентов. Продолжительность лечения не должна превышать 3 месяца в связи с риском развития поздней дискинезии. При наличии признаков поздней дискинезии лечение необходимо прекратить. \u003Cbr\u003EПри применении метоклопрамида одновременно с нейролептиками, а также при монотерапии метоклопрамидом отмечался нейролептический злокачественный синдром. Необходимо незамедлительно прекратить лечение препаратом Церукал при появлении симптомов нейролептического злокачественного синдрома и применить соответствующую терапию. \u003Cbr\u003EНеобходимо соблюдать осторожность при применении у пациентов с сопутствующими неврологическими заболеваниями и у пациентов, принимающих препараты, воздействующие на центральную нервную систему. \u003Cbr\u003EПри применении препарата Церукал также могут отмечаться симптомы болезни Паркинсона. \u003Cbr\u003EСообщалось о случаях возникновения метгемоглобинемии, которая могла быть вызвана дефицитом фермента НАДН-зависимой цитохром-b5 редуктазы. В этом случае прием препарата Церукал необходимо незамедлительно и полностью прекратить и предпринять соответствующие меры. \u003Cbr\u003EСообщалось о случаях тяжелых сердечнососудистых побочных эффектах, включая сосудистую недостаточность, выраженную брадикардию, остановку сердца и удлинение интервала QT. Необходимо соблюдать осторожность при применении препарата Церукал, у пожилых пациентов, пациентов с сердечными нарушениями (включая удлинение интервала QT), пациентов с нарушением водно-электролитного баланса, брадикардией и у пациентов, принимающих другие препараты, удлиняющие интервал QT. \u003Cbr\u003EПри почечной недостаточности средней и тяжелой степени тяжести и печеночной недостаточности тяжелой степени тяжести рекомендуется снижение дозы (см. раздел \"Способ применения и дозы\"). \u003Cbr\u003E"},{"name":"Взаимодействие","value":"Противопоказано одновременное применение метоклопрамида с леводопой или агонистами дофаминовых рецепторов,в связи с имеющимся взаимным антагонизмом. \u003Cbr\u003EАлкоголь усиливает седативный эффект метоклопрамида. \u003Cbr\u003EКомбинации, требующие соблюдения осторожности\u003Cbr\u003E В связи с прокипетическим эффектом метоклопрамида, всасывание некоторых препаратов может нарушаться. \u003Cbr\u003EМ-холиноблокаторы и производные морфина обладают взаимным антагонизмом с метоклонрамидом в отношении влияния на перистальтику желудочно-кишечного тракта. \u003Cbr\u003EЛекарственные препараты, угнетающие ЦНС (производные морфина, транквилизаторы, блокаторы H1-гистаминовых рецепторов, антидепрессанты с седативным эффектом, барбитураты, клонидин и прочие препараты этих групп) могут усиливать седативный эффект под влиянием метоклопрамида. \u003Cbr\u003EМетоклопрамид усиливает действие нейролептиков в отношении экстрапирамидных симптомов. \u003Cbr\u003EПри сопутствующем применении внутрь метоклопрамида и тетрабеназина существует вероятность возникновения дефицита дофамина, что может сопровождаться повышением жесткости мышц или их спазмом, трудностями в речи или при глотании, беспокойством, тремором, непроизвольными движениями мышц, в том числе мышц лица. Применение метоклопрамида с серотонинергическими препаратами, например, с селективными ингибиторами обратного захвата серотонина, повышает риск развития серотонинового синдрома (серотониновая интоксикация). Метоклопрамид снижает биодоступность дигоксина. Следует контролировать концентрацию дигоксина в плазме крови. Метоклопрамид повышает биодоступность циклоспорина (Сmax на 46% и экспозицию на 22%). Необходимо тщательно контролировать концентрацию циклоспорина в плазме крови. Клинические последствия такого взаимодействия не установлены. \u003Cbr\u003EЭкспозиция метоклопрамида увеличивается при одновременном применении с мощными ингибиторами изофермента CYP2D6, например, флуоксетином и пароксетином. Хотя клиническая значимость такого взаимодействия не установлена, необходимо следить за появлением у пациентов побочных реакций. \u003Cbr\u003EПри сопутствующем применении метоклопрамида с атовахоном значительно снижается концентрация атовахона в плазме крови (около 50%). Сопутствующее применение метоклопрамида с атовахоном не рекомендуется. \u003Cbr\u003EПри сопутствующем применении метоклопрамида с бромокриптином повышается концентрация бромокриптина в плазме крови. \u003Cbr\u003EМетоклопрамид усиливает всасывание тетрациклина из тонкого кишечника. Метоклопрамид усиливает всасывание мексилетина и лития. \u003Cbr\u003EМетоклопрамид уменьшает всасывание циметидина. \u003Cbr\u003E"},{"name":"Регистрационный номер","value":"П N012812/01"},{"name":"Дата государственной регистрации","value":"24.04.2019"},{"name":"Владелец регистрационного удостоверения","value":"TEVA","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["34324371:35649313","7893318:14909142"]}}},{"name":"Изготовитель","value":"PLIVA Hrvatska d.o.o."},{"name":"Фасовщик","value":"PLIVA Hrvatska d.o.o."},{"name":"Страна бренда","value":"Израиль"},{"name":"Страна-производитель","value":"Хорватия"},{"name":"Название препарата","value":"Церукал","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["17796364:17845868"]}}},{"name":"Срок годности","value":"60 мес."}]}},"fullSpecsGrouped":{"14075675745846526964":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"пищеварительная система"},{"name":"Назначение","value":"рвота, сопровождающая терапия онкологических заболеваний, тошнота"},{"name":"Показания к применению","value":"- Профилактика послеоперационной тошноты и рвоты. \u003Cbr\u003E- Симптоматическое лечение тошноты и рвоты, в том числе при острой мигрени. \u003Cbr\u003E- Профилактика тошноты и рвоты, вызванной лучевой терапией и химиотерапией. \u003Cbr\u003E"},{"name":"Противопоказания","value":"- Повышенная чувствительность к метоклопрамиду и компонентам препарата; \u003Cbr\u003E- желудочно-кишечное кровотечение, механическая кишечная непроходимость или перфорация стенки желудка и кишечника, состояния, при которых стимуляция перистальтики желудочно-кишечного тракта представляет риск; \u003Cbr\u003E- подтвержденная или подозреваемая феохромоцитома в связи с риском развития тяжелой артериальной гипертензии; \u003Cbr\u003E- поздняя дискинезия, которая развилась после лечения нейролептиками или метоклопрамидом в анамнезе; \u003Cbr\u003E- эпилепсия (увеличение частоты и тяжести припадков); \u003Cbr\u003E- болезнь Паркинсона; \u003Cbr\u003E- одновременное применение с леводопой и агонистами дофаминовых рецепторов; \u003Cbr\u003E- метгемоглобинемия вследствие приема метоклопрамида или дефицита никотинамидадениндинуклеотида (НАДИ) цитохрома-b5 в анамнезе; \u003Cbr\u003E- пролактинома или пролактинзависимая опухоль; \u003Cbr\u003E- дефицит лактазы, непереносимость лактозы, глюкозо-галактозная мальабсорбция; \u003Cbr\u003E- детский возраст до 15 лет; \u003Cbr\u003E- период грудного вскармливания."},{"name":"Состав","value":"В 1 таблетке содержится: активное вещество метоклопрамида гидрохлорида моногидрат 10,54 мг (в пересчете на метоклопрамида гидрохлорид 10,00 мг);\u003Cbr\u003Eвспомогательные вещества: крахмал картофельный 36,75 мг, лактозы моногидрат 76,65 мг, желатин 2,16 мг, кремния диоксид 2,60 мг, магния стеарат 1,30 мг.\u003Cbr\u003E"},{"name":"Действующее вещество","value":"Метоклопрамид"},{"name":"Способ применения и дозы","value":"Внутрь. \u003Cbr\u003EВзрослые и дети старше 15 лет с массой тела более 60 кг\u003Cbr\u003EРекомендуемая доза I таблетка (10 мг) до трех раз в сутки. \u003Cbr\u003EМаксимальная рекомендуемая суточная доза составляет 30 мг или 0,5 мг/кг массы тела. \u003Cbr\u003EДети старше 15 лет с массой тела менее 60 кг\u003Cbr\u003EРекомендуемая доза составляет 1/2 таблетки (5 мг) 1-3 раза в сутки. Максимальная рекомендуемая суточная доза составляет 0.5 мг/кг/сут. \u003Cbr\u003EВо избежание передозировки необходимо соблюдать минимальный интервал между приемами 6 ч, даже в случае рвоты. Максимальный срок лечения составляет 5 дней. \u003Cbr\u003EПожилые пациенты\u003Cbr\u003EУ пожилых пациентов может потребоваться снижение дозы в зависимости от показателей функции почек и печени и общего состояния. \u003Cbr\u003EПочечная недостаточность\u003Cbr\u003EУ пациентов с терминальной стадией почечной недостаточности (клиренс креатинина менее 15 мл/мин) суточная доза должна быть снижена на 75%.\u003Cbr\u003EУ пациентов с почечной недостаточностью средней или тяжелой степени тяжести (КК 15-60 мл/мин) доза должна быть снижена на 50%.\u003Cbr\u003EНарушение функции печени\u003Cbr\u003EУ пациентов с печеночной недостаточностью тяжелой степени тяжести доза должна быть снижена на 50%. \u003Cbr\u003E"},{"name":"Побочные действия","value":"Частота побочных реакций классифицирована следующим образом: очень часто (≥ 1/10), часто (≥ 1/100 - \u003C 1/10). нечасто (≥ 1/1000 - \u003C 1/100), редко (≥ 1/10000 - \u003C 1/1000), очень редко (\u003C 1/10000). частота неизвестна (не может быть оценена на основании имеющихся данных). \u003Cbr\u003EСо стороны крови и лимфатической системы: частота неизвестна метгемоглобинемия, вероятно связанная с дефицитом фермента НАДН-зависимой цитохром-b5 редуктазы, особенно у новорожденных, сульфгемоглобинемия (чаще всего при одновременном применении высоких доз серосодержащих препаратов), лейкопения, нейтропения, агранулоцитоз. \u003Cbr\u003EСо стороны сердца: нечасто брадикардия; частота неизвестна остановка сердца, которая может быть вызвана брадикардией, атриовентрикулярная блокада, блокада синусного узла, удлинение интервала QT на электрокардиограмме, аритмия типа \"пируэт\".\u003Cbr\u003EСо стороны сосудов: часто - понижение артериального давления; частота неизвестна - кардиогенный шок, острое повышение артериального давления у пациентов с феохромоцитомой. \u003Cbr\u003EСо стороны эндокринной системы*: нечасто - аменорея, гиперпролактинемия; редко - галакторея; частота неизвестна -гинекомастия. \u003Cbr\u003EЭндокринные нарушения во время продолжительного лечения связаны с гиперпролактинемией (аменорея, галакторея. гинекомастия). \u003Cbr\u003EСо стороны желудочно-кишечного тракта: часто - тошнота, диарея, запор. \u003Cbr\u003EСо стороны почек и мочевыводящих путей: частота неизвестна - полиурия, недержание мочи. \u003Cbr\u003EСо стороны половых органов и молочной железы: неизвестная частота сексуальная дисфункция, приапизм. \u003Cbr\u003EСо стороны иммунной системы: нечасто - гиперчувствительность; частота неизвестна - анафилактические реакции (в том числе анафилактический шок), аллергические реакции (крапивница, макулопапулезная сыпь). \u003Cbr\u003EСо стороны нервной системы: очень часто - сонливость; часто - астения, экстрапирамидные нарушения (особенно у детей и молодых пациентов и/или при превышении рекомендованных доз препарата, даже после однократного введения), паркинсонизм, акатизия: нечасто - дистония, дискинезия, нарушение сознания: редко - судороги, в особенности у пациентов с эпилепсией; частота неизвестна - поздняя дискинезия, иногда персистирующая, во время или после длительного лечения, в особенности у пожилых пациентов, нейролептический злокачественный синдром. \u003Cbr\u003EНарушение психики: часто - депрессия; нечасто - галлюцинации; редко спутанность сознания. \u003Cbr\u003EНежелательные реакции, наиболее часто встречающиеся при применении высоких доз препарата\u003Cbr\u003E- Экстрапирамидные симптомы: острая дистония и дискинезия, синдром паркинсонизма, акатизия развивались даже после применения однократной дозы препарата, особенно у детей и молодых пациентов (см. раздел \"Особые указания\").\u003Cbr\u003E- Сонливость, снижение уровня сознания, спутанность сознания, галлюцинации. \u003Cbr\u003E"},{"name":"Фармакологическое действие","value":"Противорвотное средство, является специфическим блокатором дофаминовых (D2) и серотониновых рецепторов. Механизм действия основан как на центральном, так и на периферическом воздействии метоклопрамида. Противорвотное действие связано с блокадой дофаминовых рецепторов головного мозга, что обуславливает повышение порога раздражения рвотного центра. Оказывает противорвотное действие, устраняет тошноту и икоту. Снижает двигательную активность пищевода, повышает тонус нижнего сфинктера пищевода, ускоряет опорожнение желудка, а также ускоряет продвижение пищи по тонкой кишке, не вызывая диарею. Нормализует выделение желчи, уменьшает спазм сфинктера Одди, не изменяет его статус, устраняет дискинезию желчного пузыря. Стимулирует секрецию пролактина."},{"name":"Фармакологическая группа","value":"противорвотные средства"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 13.33 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Хранить в защищенном от света месте, при температуре не выше 25°С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы\u003Cbr\u003EЭкстрапирамидные нарушения, сонливость, снижение уровня сознания, спутанность сознания, галлюцинации, раздражительность, головокружение, брадикардия, изменения артериального давления, остановка сердца и дыхания, боль в животе. \u003Cbr\u003EЛечение\u003Cbr\u003EВ случае развития экстрапирамидных симптомов, вызванных передозировкой или но другой причине, лечение носит исключительно симптоматический характер (бензодиазепииы у детей и/или антихолииергические противопаркинсонические препараты у взрослых). \u003Cbr\u003EТребуется симптоматическое лечение и постоянный контроль сердечной и дыхательной функций в зависимости от клинического состояния пациента. \u003Cbr\u003EСпецифического антидота не существует. \u003Cbr\u003E"},{"name":"Применение при беременности и кормлении грудью","value":"Беременность\u003Cbr\u003EМногочисленные данные, полученные о применении у беременных женщин (более 1000 описанных случаев) указывают на отсутствие фетотоксичности и способности вызывать пороки развития у плода. Мстоклопрамид можно применять во время беременности (I-II триместры) только если потенциальная польза для матери превышает потенциальный риск для плода. В связи с фармакологическими особенностями (подобно другим нейролептикам), при применении метоклопрамида в конце беременности нельзя исключить вероятность развития экстрапирамидных симптомов у новорожденного. Метоклопрамид не следует применять в конце беременности (во время III триместра). При применении метоклопрамида следует следить за состоянием новорожденного. \u003Cbr\u003EПериод грудного вскармливания\u003Cbr\u003EМетоклопрамид в небольшом количестве выделяется с грудным молоком. Нельзя исключать возможность развития\u003Cbr\u003Eпобочных реакций у ребенка. Применение метоклопрамида в период грудного вскармливания не рекомендуется. При необходимости применения препарата в период лактации следует прекратить грудное вскармливание. \u003Cbr\u003E"},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Следует соблюдать осторожность при управлении транспортными средствами и другими механизмами, т.к. прием препарата может вызывать сонливость и дискинезию."},{"name":"Особые указания","value":"С осторожностью: \u003Cbr\u003EПри применении у пожилых пациентов; у пациентов с нарушением сердечной проводимости (включая удлинение интервала QT), нарушением водноэлектролитного баланса, брадикардией, принимающих другие препараты, удлиняющие интервал QT, артериальной гипертензией; у пациентов с сопутствующими неврологическими заболеваниями, депрессией (в анамнезе); при почечной недостаточности средней и тяжелой степени тяжести (КК 15-60 мл/мин); при печеночной недостаточности тяжелой степени тяжести; при беременности.\u003Cbr\u003EСледует соблюдать осторожность при применении препарата Церукал у пожилых пациентов. \u003Cbr\u003EСо стороны нервной системы возможны экстрапирамидные нарушения, особенно у детей и молодых пациентов и/или при применении высоких доз, развивающиеся, как правило, в начале лечения или после однократного применения. Применение препарата Церукал необходимо незамедлительно прекратить в случае появления экстрапирамидных симптомов. Реакции полностью обратимы после прекращения лечения, однако могут потребовать симптоматической терапии (беизодиазепины у детей и/или антихолинергические противопаркинсонические препараты у взрослых). \u003Cbr\u003EВо избежание передозировки препарата Церукал необходимо соблюдать минимальный интервал между приемами 6 ч. даже в случае рвоты. \u003Cbr\u003EДлительное лечение препаратом Церукал может привести к развитию поздней дискинезии, потенциально необратимой, особенно у пожилых пациентов. Продолжительность лечения не должна превышать 3 месяца в связи с риском развития поздней дискинезии. При наличии признаков поздней дискинезии лечение необходимо прекратить. \u003Cbr\u003EПри применении метоклопрамида одновременно с нейролептиками, а также при монотерапии метоклопрамидом отмечался нейролептический злокачественный синдром. Необходимо незамедлительно прекратить лечение препаратом Церукал при появлении симптомов нейролептического злокачественного синдрома и применить соответствующую терапию. \u003Cbr\u003EНеобходимо соблюдать осторожность при применении у пациентов с сопутствующими неврологическими заболеваниями и у пациентов, принимающих препараты, воздействующие на центральную нервную систему. \u003Cbr\u003EПри применении препарата Церукал также могут отмечаться симптомы болезни Паркинсона. \u003Cbr\u003EСообщалось о случаях возникновения метгемоглобинемии, которая могла быть вызвана дефицитом фермента НАДН-зависимой цитохром-b5 редуктазы. В этом случае прием препарата Церукал необходимо незамедлительно и полностью прекратить и предпринять соответствующие меры. \u003Cbr\u003EСообщалось о случаях тяжелых сердечнососудистых побочных эффектах, включая сосудистую недостаточность, выраженную брадикардию, остановку сердца и удлинение интервала QT. Необходимо соблюдать осторожность при применении препарата Церукал, у пожилых пациентов, пациентов с сердечными нарушениями (включая удлинение интервала QT), пациентов с нарушением водно-электролитного баланса, брадикардией и у пациентов, принимающих другие препараты, удлиняющие интервал QT. \u003Cbr\u003EПри почечной недостаточности средней и тяжелой степени тяжести и печеночной недостаточности тяжелой степени тяжести рекомендуется снижение дозы (см. раздел \"Способ применения и дозы\"). \u003Cbr\u003E"},{"name":"Взаимодействие","value":"Противопоказано одновременное применение метоклопрамида с леводопой или агонистами дофаминовых рецепторов,в связи с имеющимся взаимным антагонизмом. \u003Cbr\u003EАлкоголь усиливает седативный эффект метоклопрамида. \u003Cbr\u003EКомбинации, требующие соблюдения осторожности\u003Cbr\u003E В связи с прокипетическим эффектом метоклопрамида, всасывание некоторых препаратов может нарушаться. \u003Cbr\u003EМ-холиноблокаторы и производные морфина обладают взаимным антагонизмом с метоклонрамидом в отношении влияния на перистальтику желудочно-кишечного тракта. \u003Cbr\u003EЛекарственные препараты, угнетающие ЦНС (производные морфина, транквилизаторы, блокаторы H1-гистаминовых рецепторов, антидепрессанты с седативным эффектом, барбитураты, клонидин и прочие препараты этих групп) могут усиливать седативный эффект под влиянием метоклопрамида. \u003Cbr\u003EМетоклопрамид усиливает действие нейролептиков в отношении экстрапирамидных симптомов. \u003Cbr\u003EПри сопутствующем применении внутрь метоклопрамида и тетрабеназина существует вероятность возникновения дефицита дофамина, что может сопровождаться повышением жесткости мышц или их спазмом, трудностями в речи или при глотании, беспокойством, тремором, непроизвольными движениями мышц, в том числе мышц лица. Применение метоклопрамида с серотонинергическими препаратами, например, с селективными ингибиторами обратного захвата серотонина, повышает риск развития серотонинового синдрома (серотониновая интоксикация). Метоклопрамид снижает биодоступность дигоксина. Следует контролировать концентрацию дигоксина в плазме крови. Метоклопрамид повышает биодоступность циклоспорина (Сmax на 46% и экспозицию на 22%). Необходимо тщательно контролировать концентрацию циклоспорина в плазме крови. Клинические последствия такого взаимодействия не установлены. \u003Cbr\u003EЭкспозиция метоклопрамида увеличивается при одновременном применении с мощными ингибиторами изофермента CYP2D6, например, флуоксетином и пароксетином. Хотя клиническая значимость такого взаимодействия не установлена, необходимо следить за появлением у пациентов побочных реакций. \u003Cbr\u003EПри сопутствующем применении метоклопрамида с атовахоном значительно снижается концентрация атовахона в плазме крови (около 50%). Сопутствующее применение метоклопрамида с атовахоном не рекомендуется. \u003Cbr\u003EПри сопутствующем применении метоклопрамида с бромокриптином повышается концентрация бромокриптина в плазме крови. \u003Cbr\u003EМетоклопрамид усиливает всасывание тетрациклина из тонкого кишечника. Метоклопрамид усиливает всасывание мексилетина и лития. \u003Cbr\u003EМетоклопрамид уменьшает всасывание циметидина. \u003Cbr\u003E"},{"name":"Регистрационный номер","value":"П N012812/01"},{"name":"Дата государственной регистрации","value":"24.04.2019"},{"name":"Владелец регистрационного удостоверения","value":"TEVA"},{"name":"Изготовитель","value":"PLIVA Hrvatska d.o.o."},{"name":"Фасовщик","value":"PLIVA Hrvatska d.o.o."},{"name":"Страна бренда","value":"Израиль"},{"name":"Страна-производитель","value":"Хорватия"},{"name":"Название препарата","value":"Церукал"},{"name":"Срок годности","value":"60 мес."}]}],"transitionId":"tr_1659407373662436042"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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142 ₽

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    Цена 56 ₽
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  • Мезим Форте таб. п/о, 20 шт.
    –1 %
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    Мезим Форте таб. п/о, 20 шт.

    Рейтинг товара: 4.8 из 5
    на основе 182 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 100 ₽ вместо 101
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  • Полисорб МП пор. д/приг. сусп. д/вн. приема, 12 г
    –1 %
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    Полисорб МП пор. д/приг. сусп. д/вн. приема, 12 г

    Рейтинг товара: 4.9 из 5
    на основе 104 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 274 ₽ вместо 277
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  • Мотилиум экспресс таб. д/рассас., 10 мг, 10 шт.
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    Мотилиум экспресс таб. д/рассас., 10 мг, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 5 оценок
    Цена 820 ₽
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  • Метоклопрамид р-р для в/в введ. введ. и в/м, 5 мг/мл, 2 мл, 10 шт.
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    Метоклопрамид р-р для в/в введ. введ. и в/м, 5 мг/мл, 2 мл, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 118 ₽
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  • Энтерофурил капс., 200 мг, 16 шт.
    –1 %
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    Энтерофурил капс., 200 мг, 16 шт.

    Рейтинг товара: 4.9 из 5
    на основе 101 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 387 ₽ вместо 391
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  • Метоклопрамид р-р для в/в и в/м введ., 5 мг/мл, 2 мл, 10 шт.
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    Метоклопрамид р-р для в/в и в/м введ., 5 мг/мл, 2 мл, 10 шт.

    Рейтинг товара: 4.8 из 5
    на основе 8 оценок
    Цена 74 ₽
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  • Смекта пор. д/приг. сусп. д/вн. приема, 3 г, 20 шт., ваниль
    –1 %
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    Смекта пор. д/приг. сусп. д/вн. приема, 3 г, 20 шт., ваниль

    Рейтинг товара: 4.9 из 5
    на основе 73 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 171 ₽ вместо 173
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  • Лоперамид таб., 2 мг, 10 шт.
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    Лоперамид таб., 2 мг, 10 шт.

    Рейтинг товара: 4.9 из 5
    на основе 125 оценок
    Цена 28 ₽
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  • Энтеросгель паста д/вн.приема, 225 г, сладкий
    –1 %
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    Энтеросгель паста д/вн.приема, 225 г, сладкий

    Рейтинг товара: 5 из 5
    на основе 330 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 490 ₽ вместо 495
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  • Панкреатин таб. п/о кш/раств. (блистеры), 25 ЕД, 20 шт.
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    Панкреатин таб. п/о кш/раств. (блистеры), 25 ЕД, 20 шт.

    Рейтинг товара: 4.9 из 5
    на основе 208 оценок
    Цена 35 ₽
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Инструкция

Показания к применению

- Профилактика послеоперационной тошноты и рвоты.
- Симптоматическое лечение тошноты и рвоты, в том числе при острой мигрени.
- Профилактика тошноты и рвоты, вызванной лучевой терапией и химиотерапией.

Противопоказания

- Повышенная чувствительность к метоклопрамиду и компонентам препарата;
- желудочно-кишечное кровотечение, механическая кишечная непроходимость или перфорация стенки желудка и кишечника, состояния, при которых стимуляция перистальтики желудочно-кишечного тракта представляет риск;
- подтвержденная или подозреваемая феохромоцитома в связи с риском развития тяжелой артериальной гипертензии;
- поздняя дискинезия, которая развилась после лечения нейролептиками или метоклопрамидом в анамнезе;
- эпилепсия (увеличение частоты и тяжести припадков);
- болезнь Паркинсона;
- одновременное применение с леводопой и агонистами дофаминовых рецепторов;
- метгемоглобинемия вследствие приема метоклопрамида или дефицита никотинамидадениндинуклеотида (НАДИ) цитохрома-b5 в анамнезе;
- пролактинома или пролактинзависимая опухоль;
- дефицит лактазы, непереносимость лактозы, глюкозо-галактозная мальабсорбция;
- детский возраст до 15 лет;
- период грудного вскармливания.

Способ применения и дозы

Внутрь.
Взрослые и дети старше 15 лет с массой тела более 60 кг
Рекомендуемая доза I таблетка (10 мг) до трех раз в сутки.
Максимальная рекомендуемая суточная доза составляет 30 мг или 0,5 мг/кг массы тела.
Дети старше 15 лет с массой тела менее 60 кг
Рекомендуемая доза составляет 1/2 таблетки (5 мг) 1-3 раза в сутки. Максимальная рекомендуемая суточная доза составляет 0.5 мг/кг/сут.
Во избежание передозировки необходимо соблюдать минимальный интервал между приемами 6 ч, даже в случае рвоты. Максимальный срок лечения составляет 5 дней.
Пожилые пациенты
У пожилых пациентов может потребоваться снижение дозы в зависимости от показателей функции почек и печени и общего состояния.
Почечная недостаточность
У пациентов с терминальной стадией почечной недостаточности (клиренс креатинина менее 15 мл/мин) суточная доза должна быть снижена на 75%.
У пациентов с почечной недостаточностью средней или тяжелой степени тяжести (КК 15-60 мл/мин) доза должна быть снижена на 50%.
Нарушение функции печени
У пациентов с печеночной недостаточностью тяжелой степени тяжести доза должна быть снижена на 50%.
Полная инструкция
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Церукал таб.
Церукал таб., 10 мг, 50 шт.
5.0
(8)
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5 вопросов
Инструкция

142 ₽

Скидка: 10%
–10 %
Вместо:158 ₽
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5.0
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У продавца:8 оценок·3 отзыва
У всех продавцов:39 оценок·21 отзыв
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6 месяцев назад • Анастасия Сушкова • Куплен на Маркете
Достоинства: быстро пришло
Недостатки: аптека рано закрывается ((
Комментарий: Всё понравилось!!!
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7 месяцев назад • Ольга Лебедева • Куплен на Маркете
Достоинства: Действует
Комментарий: прописал ветеринар кошке от рвоты, помогает.
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7 месяцев назад • Boris A. • Куплен на Маркете
Достоинства: Хороший препарат
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