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Коринфар таб. пролонг. действ.п.п.о., 10 мг, 50 шт.

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5.0
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Коротко о товаре

Артикул Маркета
3123173980
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
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другим производным 1,4-дигидропиридина или к другим компонентам препарата.\u003Cbr\u003EС осторожностью: стеноз митрального клапана, гипертрофическая обструктивная кардиомиопатия, выраженная брадикардия или тахикардия, СССУ, злокачественная артериальная гипертензия, гиповолемия, тяжелые нарушения мозгового кровообращения, инфаркт миокарда с левожелудочковой недостаточностью, непроходимость ЖКТ, почечная и печеночная недостаточность, гемодиализ (из-за риска возникновения артериальной гипотензии), II и III триместры беременности, детский и подростковый возраст до 18 лет (эффективность и безопасность не установлены), одновременный прием бета-адреноблокаторов, дигоксина."},{"name":"Состав","value":"Действующее вещество: нифедипин – 10 мг.\u003Cbr\u003EВспомогательные вещества: лактозы моногидрат – 15.8 мг, крахмал картофельный – 15.7 мг, целлюлоза микрокристаллическая – 15.5 мг, повидон К25 – 2.7 мг, магния стеарат – 0.3 мг.\u003Cbr/\u003E"},{"name":"Действующее 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Доза препарата подбирается врачом индивидуально в соответствии с тяжестью заболевания и чувствительностью больного к препарату. Для пациентов с сопутствующими тяжелыми цереброваскулярными заболеваниями и у пациентов пожилого возраста дозу препарата следует уменьшить.\u003Cbr\u003EОдновременный прием пищи задерживает, но не уменьшает всасывание нифедипина из ЖКТ.\u003Cbr\u003EХроническая стабильная и вазоспастическая стенокардия\u003Cbr\u003EНачальная доза - 10 мг (1 таб.) 2-3 раза/сут. При недостаточно выраженном клиническом эффекте дозу препарата постепенно увеличивают до 2 таб. (20 мг) 1-2 раза/сут. Максимальная суточная доза - 40 мг (4 таб./сут).\u003Cbr\u003EЭссенциальная гипертензия\u003Cbr\u003EСредняя суточная доза - 10 мг (1 таб.) 2-3 раза/сут.\u003Cbr\u003EПри недостаточно выраженном клиническом эффекте возможно постепенное увеличение дозы препарата до 20 мг (2 таб.) 2 раза/сут. Максимальная суточная доза - 40 мг (4 таб./сут).\u003Cbr\u003EПри 2-кратном назначении минимальный интервал между приемами препарата должен составлять не менее 4 ч.\u003Cbr\u003EДлительность курса лечения определяется лечащим врачом."},{"name":"Побочные действия","value":"Со стороны сердечно-сосудистой системы: тахикардия, сердцебиение, аритмии, периферические отеки (лодыжек, стоп, голеней), проявления чрезмерной вазодилатации (бессимптомное снижение артериального давления, развитие или усугубление сердечной недостаточности, \"приливы\" крови к коже лица, гиперемия кожи лица, чувство жара), выраженное снижение АД (редко), синкопе. У некоторых пациентов, особенно в начале лечения или при увеличении дозы, возможно появление приступов стенокардии и в единичных случаях - развития инфаркта миокарда, что требует отмены препарата.\u003Cbr\u003EСо стороны нервной системы: головная боль, головокружение, общая слабость, повышенная утомляемость, сонливость. При длительном приеме препарата в высоких дозах - парестезии конечностей, тремор, экстрапирамидные (паркинсонические) нарушения (атаксия, \"маскообразное\" лицо, шаркающая походка, тремор кистей и пальцев рук, затрудненное глотание), депрессия.\u003Cbr\u003EСо стороны пищеварительной системы: диспепсия (тошнота, диарея или запор), сухость во рту, метеоризм, повышение аппетита; редко - гиперплазия десен, полностью исчезающая после отмены препарата; при длительном приеме - нарушения функции печени (внутрипеченочный холестаз, повышение активности печеночных трансаминаз).\u003Cbr\u003EСо стороны костно-мышечной системы: артрит, миалгия, отечность суставов, судороги верхних и нижних конечностей.\u003Cbr\u003EАллергические реакции: редко - кожный зуд, крапивница, экзантемы, аутоиммунный гепатит, эксфолиативный дерматит, фотодерматит, анафилактические реакции.\u003Cbr\u003EСо стороны системы кроветворения: анемия, лейкопения, тромбоцитопения, тромбоцитопеническая пурпура, агранулоцитоз.\u003Cbr\u003EСо стороны мочевыделительной системы: увеличение суточного диуреза, ухудшение функции почек (у больных с почечной недостаточностью).\u003Cbr\u003EПрочие: редко - нарушения зрения (в т.ч. транзиторная слепота при максимальной концентрации нифедипина в плазме крови), гинекомастия (у пожилых больных, полностью исчезающая после отмены препарата), галакторея, гипергликемия, отек легких, бронхоспазм, увеличение массы тела."},{"name":"Фармакологическое действие","value":"Селективный блокатор медленных кальциевых каналов (БМКК), производное 1,4-дигидропиридина. Оказывает антиангинальное и гипотензивное действие. Уменьшает ток внеклеточного Са2+ внутрь кардиомиоцитов и гладкомышечных клеток коронарных и периферических артерий; в высоких дозах ингибирует высвобождение Са2+ из внутриклеточных депо.\u003Cbr\u003EВ терапевтических дозах нормализует трансмембранный ток Са2+, нарушенный при ряде патологических состояний, прежде всего при артериальной гипертензии. Не влияет на тонус вен. Усиливает коронарный кровоток, улучшает кровоснабжение ишемизированных зон миокарда без развития феномена \"обкрадывания\", активирует функционирование коллатералей.\u003Cbr\u003EРасширяя периферические артерии, снижает ОПСС, тонус миокарда, постнагрузку и потребность миокарда в кислороде. Практически не влияет на синоатриальный узел и AV-узел, обладает слабой антиаритмической активностью.\u003Cbr\u003EУсиливает почечный кровоток, вызывает умеренный натрийурез.\u003Cbr\u003EОтрицательное хроно-, дромо- и инотропное действие перекрывается рефлекторной активацией симпатоадреналовой системы и увеличением ЧСС в ответ на периферическую вазодилатацию.\u003Cbr\u003EВремя наступления клинического эффекта - 20 мин и его длительность - 4-6 ч.\u003Cbr\u003EПри длительном приеме (2-3 месяца) развивается толерантность к действию препарата."},{"name":"Фармакологическая группа","value":"блокатор \"медленных\" кальциевых каналов"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"Препарат следует хранить в недоступном для детей, защищенном от света месте при температуре не выше 25°С. Срок годности - 5 лет."},{"name":"Передозировка","value":"Симптомы: головная боль, гиперемия кожи лица, длительное выраженное снижение АД, угнетение функции синусового узла, брадикардия/тахикардия, брадиаритмия. При тяжелом отравлении - потеря сознания, кома.\u003Cbr\u003EЛечение: проведение симптоматической терапии. При тяжелом отравлении (коллапс, угнетение синусового узла) проводят промывание желудка (при необходимости, тонкого кишечника), назначают активированный уголь. Антидотом являются препараты кальция, показано в/в введение 10% кальция хлорида или кальция глюконата, с последующим переводом на длительную инфузию. При выраженном снижении АД показано медленное в/в введение допамина, добутамина, адреналина или норадреналина. Рекомендуется проводить контроль содержания глюкозы (может снижаться высвобождение инсулина) и электролитов в крови (К+, Са2+). При развитии сердечной недостаточности - в/в введение строфантина. При нарушениях проводимости - атропин, изопреналин или искусственный водитель ритма. Гемодиализ не эффективен, рекомендуется плазмаферез."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения необходимо соблюдать осторожность при вождении автотранспорта и занятии другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"В период лечения необходимо воздерживаться от приема этанола. Прекращать лечение препаратом рекомендуется постепенно.\u003Cbr\u003EСледует иметь в виду, что в начале лечения может возникнуть стенокардия, особенно после недавней резкой отмены бета-адреноблокаторов (последние следует отменять постепенно).\u003Cbr\u003EОдновременное назначение бета-адреноблокаторов необходимо проводить в условиях тщательного врачебного контроля, поскольку это может обусловить чрезмерное снижение АД, а в некоторых случаях - усугубление симптомов сердечной недостаточности.\u003Cbr\u003EПри выраженной сердечной недостаточности препарат дозируют с большой осторожностью.\u003Cbr\u003EДиагностическими критериями назначения препарата при вазоспастической стенокардии являются: классическая клиническая картина, сопровождающаяся повышением сегмента ST, возникновение эргоновин-индуцированной стенокардии или спазма коронарных артерий, выявление коронароспазма при ангиографии или выявление ангиоспастического компонента без подтверждения (например, при разном пороге напряжения или при нестабильной стенокардии, когда данные ЭКГ свидетельствуют о преходящем ангиоспазме).\u003Cbr\u003EДля пациентов с тяжелой обструктивной кардиомиопатией существует риск увеличения частоты, тяжести проявления и продолжительности приступов стенокардии после приема нифедипина; в данном случае необходима отмена препарата.\u003Cbr\u003EУ пациентов с необратимой почечной недостаточностью, находящихся на гемодиализе, имеющих высокое АД и сниженный ОЦК, препарат следует применять осторожно, т.к. возможно резкое падение АД. За больными с нарушением функции печени устанавливается тщательное наблюдение; при необходимости дозу препарата снижают и/или используют другие лекарственные формы нифедипина.\u003Cbr\u003EПри необходимости хирургического вмешательства под наркозом необходимо информировать врача-анестезиолога о лечении пациента нифедипином.\u003Cbr\u003EПри экстракорпоральном оплодотворении в отдельных случаях БМКК вызывали изменения в головной части сперматозоидов, что может привести к нарушению функций сперматозоидов. В случаях, при которых повторное экстракорпоральное оплодотворение не осуществилось по неясной причине, применение БМКК, включая нифедипин, можно считать возможной причиной неудачи.\u003Cbr\u003EВо время лечения возможно получение ложноположительного результата прямой реакции Кумбса и лабораторных тестов на антинуклеарные антитела.\u003Cbr\u003EПри спектофотометрическом определении ванилил-миндальной кислоты в моче нифедипин может быть причиной получения ложно-завышенного результата, однако, на результаты тестов, проведенных с помощью ВЭЖХ, нифедипин влияния не оказывает.\u003Cbr\u003EС осторожностью следует проводить одновременное лечение нифедипином, дизопирамидом и флекаинидом вследствие возможного усиления инотропного эффекта."},{"name":"Взаимодействие","value":"При одновременном применении других гипотензивных средств, а также трициклических антидепрессантов, нитратов, циметидина, ингаляционных анестетиков, диуретиков гипотензивный эффект нифедипина может усиливаться.\u003Cbr\u003EБМКК могут еще больше усиливать отрицательное инотропное действие таких антиаритмических средств, как амиодарон и хинидин.\u003Cbr\u003EПри комбинировании нифедипина с нитратами усиливается тахикардия.\u003Cbr\u003EДилтиазем подавляет метаболизм нифедипина в организме, что может потребовать снижения дозы нифедипина при одновременном назначении этих препаратов.\u003Cbr\u003EСнижает концентрацию хинидина в плазме крови.\u003Cbr\u003EПовышает концентрацию дигоксина и теофиллина в плазме крови.\u003Cbr\u003EРифампицин ускоряет метаболизм нифедипина, не рекомендуется совместное назначение.\u003Cbr\u003EПри одновременном назначении с цефалоспоринами (например, цефиксим) может увеличиться концентрация цефалоспоринов в крови.\u003Cbr\u003EСимпатомиметики, НПВС (подавление синтеза простагландинов в почках и задержка ионов натрия и жидкости в организме), эстрогены (задержка жидкости в организме) снижают гипотензивный эффект.\u003Cbr\u003EНифедипин может вытеснять из связи с белками препараты с высокой степенью связывания (в т.ч. непрямые антикоагулянты - производные кумарина и индандиона, противосудорожные, НПВС, хинин, салицилаты, сульфинпиразон), вследствие этого возможно повышение их концентраций в плазме крови.\u003Cbr\u003EНифедипин подавляет метаболизм празозина и других альфа-адреноблокаторов, что может привести к усилению гипотензивного эффекта.\u003Cbr\u003EПри необходимости дозу винкристина снижают, т.к. нифедипин тормозит его выведение из организма, что может вызвать усиление побочных эффектов.\u003Cbr\u003EПрепараты лития могут усиливать токсические эффекты (тошнота, рвота, диарея, атаксия, тремор, шум в ушах).\u003Cbr\u003EПри одновременном назначении прокаинамида, хинидина и других препаратов, вызывающих удлинение интервала QT, риск значительного удлинения интервала QT возрастает.\u003Cbr\u003EГрейпфрутовый сок подавляет метаболизм нифедипина в организме, поэтому он противопоказан во время лечения нифедипином.\u003Cbr\u003EНифедипин метаболизируется с помощью изофермента CYP3А, в связи с этим одновременное применение препаратов, ингибирующих данную систему может привести к взаимодействию данного препарата и нифедипина: так, макролиды, противовирусные препараты (например, ампренавир, индинавир, нелфинавир, ритонавир или саквинавир), противогрибковые средства группы азолов (кетоконазол, итраконазол или флуконазол) вызывают увеличение концентрации нифедипина в плазме крови.\u003Cbr\u003EПринимая во внимание опыт применения БМКК нимодипина, нельзя исключить аналогичные взаимодействия также с нифедипином: карбамазепин, фенобарбитал могут вызвать снижение концентрации нифедипина в плазме крови, а вальпроевая кислота - увеличение концентрации нифедипина в плазме крови."},{"name":"Регистрационный номер","value":"П N015326/01"},{"name":"Дата государственной регистрации","value":"22.01.2019"},{"name":"Владелец регистрационного удостоверения","value":"TEVA","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["34324371:35649313","7893318:14909142"]}}},{"name":"Изготовитель","value":"PLIVA Hrvatska d.o.o."},{"name":"Страна бренда","value":"Израиль"},{"name":"Страна-производитель","value":"Хорватия"},{"name":"Название препарата","value":"Коринфар","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["17796364:18017968"]}}},{"name":"Срок годности","value":"1510 дн."}]}},"fullSpecsGrouped":{"9490587063779148309":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"кровеносная система, кровеносные сосуды, сердце"},{"name":"Назначение","value":"артериальная гипертензия, гипертония, стенокардия, стенокардия Принцметала"},{"name":"Показания к применению","value":"— хроническая стабильная стенокардия (стенокардия напряжения);\u003Cbr\u003E— стенокардия Принцметала (вариантная стенокардия);\u003Cbr\u003E— артериальная гипертензия."},{"name":"Противопоказания","value":"— артериальная гипотензия (систолическое АД ниже 90 мм рт. ст.);\u003Cbr\u003E— кардиогенный шок, коллапс;\u003Cbr\u003E— хроническая сердечная недостаточность в стадии декомпенсации;\u003Cbr\u003E— выраженный аортальный стеноз;\u003Cbr\u003E— нестабильная стенокардия;\u003Cbr\u003E— острый инфаркт миокарда (первые 4 недели);\u003Cbr\u003E— совместное применение с рифампицином;\u003Cbr\u003E— I триместр беременности;\u003Cbr\u003E— период лактации (грудного вскармливания);\u003Cbr\u003E— повышенная чувствительность к нифедипину и другим производным 1,4-дигидропиридина или к другим компонентам препарата.\u003Cbr\u003EС осторожностью: стеноз митрального клапана, гипертрофическая обструктивная кардиомиопатия, выраженная брадикардия или тахикардия, СССУ, злокачественная артериальная гипертензия, гиповолемия, тяжелые нарушения мозгового кровообращения, инфаркт миокарда с левожелудочковой недостаточностью, непроходимость ЖКТ, почечная и печеночная недостаточность, гемодиализ (из-за риска возникновения артериальной гипотензии), II и III триместры беременности, детский и подростковый возраст до 18 лет (эффективность и безопасность не установлены), одновременный прием бета-адреноблокаторов, дигоксина."},{"name":"Состав","value":"Действующее вещество: нифедипин – 10 мг.\u003Cbr\u003EВспомогательные вещества: лактозы моногидрат – 15.8 мг, крахмал картофельный – 15.7 мг, целлюлоза микрокристаллическая – 15.5 мг, повидон К25 – 2.7 мг, магния стеарат – 0.3 мг.\u003Cbr/\u003E"},{"name":"Действующее вещество","value":"Нифедипин"},{"name":"Способ применения и дозы","value":"Внутрь после еды, не разжевывая и запивая достаточным количеством жидкости. Доза препарата подбирается врачом индивидуально в соответствии с тяжестью заболевания и чувствительностью больного к препарату. Для пациентов с сопутствующими тяжелыми цереброваскулярными заболеваниями и у пациентов пожилого возраста дозу препарата следует уменьшить.\u003Cbr\u003EОдновременный прием пищи задерживает, но не уменьшает всасывание нифедипина из ЖКТ.\u003Cbr\u003EХроническая стабильная и вазоспастическая стенокардия\u003Cbr\u003EНачальная доза - 10 мг (1 таб.) 2-3 раза/сут. При недостаточно выраженном клиническом эффекте дозу препарата постепенно увеличивают до 2 таб. (20 мг) 1-2 раза/сут. Максимальная суточная доза - 40 мг (4 таб./сут).\u003Cbr\u003EЭссенциальная гипертензия\u003Cbr\u003EСредняя суточная доза - 10 мг (1 таб.) 2-3 раза/сут.\u003Cbr\u003EПри недостаточно выраженном клиническом эффекте возможно постепенное увеличение дозы препарата до 20 мг (2 таб.) 2 раза/сут. Максимальная суточная доза - 40 мг (4 таб./сут).\u003Cbr\u003EПри 2-кратном назначении минимальный интервал между приемами препарата должен составлять не менее 4 ч.\u003Cbr\u003EДлительность курса лечения определяется лечащим врачом."},{"name":"Побочные действия","value":"Со стороны сердечно-сосудистой системы: тахикардия, сердцебиение, аритмии, периферические отеки (лодыжек, стоп, голеней), проявления чрезмерной вазодилатации (бессимптомное снижение артериального давления, развитие или усугубление сердечной недостаточности, \"приливы\" крови к коже лица, гиперемия кожи лица, чувство жара), выраженное снижение АД (редко), синкопе. У некоторых пациентов, особенно в начале лечения или при увеличении дозы, возможно появление приступов стенокардии и в единичных случаях - развития инфаркта миокарда, что требует отмены препарата.\u003Cbr\u003EСо стороны нервной системы: головная боль, головокружение, общая слабость, повышенная утомляемость, сонливость. При длительном приеме препарата в высоких дозах - парестезии конечностей, тремор, экстрапирамидные (паркинсонические) нарушения (атаксия, \"маскообразное\" лицо, шаркающая походка, тремор кистей и пальцев рук, затрудненное глотание), депрессия.\u003Cbr\u003EСо стороны пищеварительной системы: диспепсия (тошнота, диарея или запор), сухость во рту, метеоризм, повышение аппетита; редко - гиперплазия десен, полностью исчезающая после отмены препарата; при длительном приеме - нарушения функции печени (внутрипеченочный холестаз, повышение активности печеночных трансаминаз).\u003Cbr\u003EСо стороны костно-мышечной системы: артрит, миалгия, отечность суставов, судороги верхних и нижних конечностей.\u003Cbr\u003EАллергические реакции: редко - кожный зуд, крапивница, экзантемы, аутоиммунный гепатит, эксфолиативный дерматит, фотодерматит, анафилактические реакции.\u003Cbr\u003EСо стороны системы кроветворения: анемия, лейкопения, тромбоцитопения, тромбоцитопеническая пурпура, агранулоцитоз.\u003Cbr\u003EСо стороны мочевыделительной системы: увеличение суточного диуреза, ухудшение функции почек (у больных с почечной недостаточностью).\u003Cbr\u003EПрочие: редко - нарушения зрения (в т.ч. транзиторная слепота при максимальной концентрации нифедипина в плазме крови), гинекомастия (у пожилых больных, полностью исчезающая после отмены препарата), галакторея, гипергликемия, отек легких, бронхоспазм, увеличение массы тела."},{"name":"Фармакологическое действие","value":"Селективный блокатор медленных кальциевых каналов (БМКК), производное 1,4-дигидропиридина. Оказывает антиангинальное и гипотензивное действие. Уменьшает ток внеклеточного Са2+ внутрь кардиомиоцитов и гладкомышечных клеток коронарных и периферических артерий; в высоких дозах ингибирует высвобождение Са2+ из внутриклеточных депо.\u003Cbr\u003EВ терапевтических дозах нормализует трансмембранный ток Са2+, нарушенный при ряде патологических состояний, прежде всего при артериальной гипертензии. Не влияет на тонус вен. Усиливает коронарный кровоток, улучшает кровоснабжение ишемизированных зон миокарда без развития феномена \"обкрадывания\", активирует функционирование коллатералей.\u003Cbr\u003EРасширяя периферические артерии, снижает ОПСС, тонус миокарда, постнагрузку и потребность миокарда в кислороде. Практически не влияет на синоатриальный узел и AV-узел, обладает слабой антиаритмической активностью.\u003Cbr\u003EУсиливает почечный кровоток, вызывает умеренный натрийурез.\u003Cbr\u003EОтрицательное хроно-, дромо- и инотропное действие перекрывается рефлекторной активацией симпатоадреналовой системы и увеличением ЧСС в ответ на периферическую вазодилатацию.\u003Cbr\u003EВремя наступления клинического эффекта - 20 мин и его длительность - 4-6 ч.\u003Cbr\u003EПри длительном приеме (2-3 месяца) развивается толерантность к действию препарата."},{"name":"Фармакологическая группа","value":"блокатор \"медленных\" кальциевых каналов"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Препарат следует хранить в недоступном для детей, защищенном от света месте при температуре не выше 25°С. Срок годности - 5 лет."},{"name":"Передозировка","value":"Симптомы: головная боль, гиперемия кожи лица, длительное выраженное снижение АД, угнетение функции синусового узла, брадикардия/тахикардия, брадиаритмия. При тяжелом отравлении - потеря сознания, кома.\u003Cbr\u003EЛечение: проведение симптоматической терапии. При тяжелом отравлении (коллапс, угнетение синусового узла) проводят промывание желудка (при необходимости, тонкого кишечника), назначают активированный уголь. Антидотом являются препараты кальция, показано в/в введение 10% кальция хлорида или кальция глюконата, с последующим переводом на длительную инфузию. При выраженном снижении АД показано медленное в/в введение допамина, добутамина, адреналина или норадреналина. Рекомендуется проводить контроль содержания глюкозы (может снижаться высвобождение инсулина) и электролитов в крови (К+, Са2+). При развитии сердечной недостаточности - в/в введение строфантина. При нарушениях проводимости - атропин, изопреналин или искусственный водитель ритма. Гемодиализ не эффективен, рекомендуется плазмаферез."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения необходимо соблюдать осторожность при вождении автотранспорта и занятии другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"В период лечения необходимо воздерживаться от приема этанола. Прекращать лечение препаратом рекомендуется постепенно.\u003Cbr\u003EСледует иметь в виду, что в начале лечения может возникнуть стенокардия, особенно после недавней резкой отмены бета-адреноблокаторов (последние следует отменять постепенно).\u003Cbr\u003EОдновременное назначение бета-адреноблокаторов необходимо проводить в условиях тщательного врачебного контроля, поскольку это может обусловить чрезмерное снижение АД, а в некоторых случаях - усугубление симптомов сердечной недостаточности.\u003Cbr\u003EПри выраженной сердечной недостаточности препарат дозируют с большой осторожностью.\u003Cbr\u003EДиагностическими критериями назначения препарата при вазоспастической стенокардии являются: классическая клиническая картина, сопровождающаяся повышением сегмента ST, возникновение эргоновин-индуцированной стенокардии или спазма коронарных артерий, выявление коронароспазма при ангиографии или выявление ангиоспастического компонента без подтверждения (например, при разном пороге напряжения или при нестабильной стенокардии, когда данные ЭКГ свидетельствуют о преходящем ангиоспазме).\u003Cbr\u003EДля пациентов с тяжелой обструктивной кардиомиопатией существует риск увеличения частоты, тяжести проявления и продолжительности приступов стенокардии после приема нифедипина; в данном случае необходима отмена препарата.\u003Cbr\u003EУ пациентов с необратимой почечной недостаточностью, находящихся на гемодиализе, имеющих высокое АД и сниженный ОЦК, препарат следует применять осторожно, т.к. возможно резкое падение АД. За больными с нарушением функции печени устанавливается тщательное наблюдение; при необходимости дозу препарата снижают и/или используют другие лекарственные формы нифедипина.\u003Cbr\u003EПри необходимости хирургического вмешательства под наркозом необходимо информировать врача-анестезиолога о лечении пациента нифедипином.\u003Cbr\u003EПри экстракорпоральном оплодотворении в отдельных случаях БМКК вызывали изменения в головной части сперматозоидов, что может привести к нарушению функций сперматозоидов. В случаях, при которых повторное экстракорпоральное оплодотворение не осуществилось по неясной причине, применение БМКК, включая нифедипин, можно считать возможной причиной неудачи.\u003Cbr\u003EВо время лечения возможно получение ложноположительного результата прямой реакции Кумбса и лабораторных тестов на антинуклеарные антитела.\u003Cbr\u003EПри спектофотометрическом определении ванилил-миндальной кислоты в моче нифедипин может быть причиной получения ложно-завышенного результата, однако, на результаты тестов, проведенных с помощью ВЭЖХ, нифедипин влияния не оказывает.\u003Cbr\u003EС осторожностью следует проводить одновременное лечение нифедипином, дизопирамидом и флекаинидом вследствие возможного усиления инотропного эффекта."},{"name":"Взаимодействие","value":"При одновременном применении других гипотензивных средств, а также трициклических антидепрессантов, нитратов, циметидина, ингаляционных анестетиков, диуретиков гипотензивный эффект нифедипина может усиливаться.\u003Cbr\u003EБМКК могут еще больше усиливать отрицательное инотропное действие таких антиаритмических средств, как амиодарон и хинидин.\u003Cbr\u003EПри комбинировании нифедипина с нитратами усиливается тахикардия.\u003Cbr\u003EДилтиазем подавляет метаболизм нифедипина в организме, что может потребовать снижения дозы нифедипина при одновременном назначении этих препаратов.\u003Cbr\u003EСнижает концентрацию хинидина в плазме крови.\u003Cbr\u003EПовышает концентрацию дигоксина и теофиллина в плазме крови.\u003Cbr\u003EРифампицин ускоряет метаболизм нифедипина, не рекомендуется совместное назначение.\u003Cbr\u003EПри одновременном назначении с цефалоспоринами (например, цефиксим) может увеличиться концентрация цефалоспоринов в крови.\u003Cbr\u003EСимпатомиметики, НПВС (подавление синтеза простагландинов в почках и задержка ионов натрия и жидкости в организме), эстрогены (задержка жидкости в организме) снижают гипотензивный эффект.\u003Cbr\u003EНифедипин может вытеснять из связи с белками препараты с высокой степенью связывания (в т.ч. непрямые антикоагулянты - производные кумарина и индандиона, противосудорожные, НПВС, хинин, салицилаты, сульфинпиразон), вследствие этого возможно повышение их концентраций в плазме крови.\u003Cbr\u003EНифедипин подавляет метаболизм празозина и других альфа-адреноблокаторов, что может привести к усилению гипотензивного эффекта.\u003Cbr\u003EПри необходимости дозу винкристина снижают, т.к. нифедипин тормозит его выведение из организма, что может вызвать усиление побочных эффектов.\u003Cbr\u003EПрепараты лития могут усиливать токсические эффекты (тошнота, рвота, диарея, атаксия, тремор, шум в ушах).\u003Cbr\u003EПри одновременном назначении прокаинамида, хинидина и других препаратов, вызывающих удлинение интервала QT, риск значительного удлинения интервала QT возрастает.\u003Cbr\u003EГрейпфрутовый сок подавляет метаболизм нифедипина в организме, поэтому он противопоказан во время лечения нифедипином.\u003Cbr\u003EНифедипин метаболизируется с помощью изофермента CYP3А, в связи с этим одновременное применение препаратов, ингибирующих данную систему может привести к взаимодействию данного препарата и нифедипина: так, макролиды, противовирусные препараты (например, ампренавир, индинавир, нелфинавир, ритонавир или саквинавир), противогрибковые средства группы азолов (кетоконазол, итраконазол или флуконазол) вызывают увеличение концентрации нифедипина в плазме крови.\u003Cbr\u003EПринимая во внимание опыт применения БМКК нимодипина, нельзя исключить аналогичные взаимодействия также с нифедипином: карбамазепин, фенобарбитал могут вызвать снижение концентрации нифедипина в плазме крови, а вальпроевая кислота - увеличение концентрации нифедипина в плазме крови."},{"name":"Регистрационный номер","value":"П N015326/01"},{"name":"Дата государственной регистрации","value":"22.01.2019"},{"name":"Владелец регистрационного удостоверения","value":"TEVA"},{"name":"Изготовитель","value":"PLIVA Hrvatska d.o.o."},{"name":"Страна бренда","value":"Израиль"},{"name":"Страна-производитель","value":"Хорватия"},{"name":"Название препарата","value":"Коринфар"},{"name":"Срок годности","value":"1510 дн."}]}],"transitionId":"tr_11829348022728041913"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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  • Сердечные травы таб., 300 мг, 23 г, 30 шт.
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    Сердечные травы таб., 300 мг, 23 г, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 4 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 341 ₽ вместо 347
    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травы таб., 300 мг, 23 г, 30 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  • Коринфар таб. пролонг. высвоб. п/о плен., 10 мг, 100 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-5io2ml8f2f8/toggleWishlist":{"skuId":"101482994774","productId":334554152,"offerId":"OmgdwuAFqhnNJfNJsa2jow","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQzPHXy4CxisJDEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIqMjDnwEQ1rjuhvoCGNb9jQcg19zBBw==","sign":"SclOEKWwyU+qVz8RwfHOD6LKUmiYj2ZViQFiUlcb4Fo="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-5io2ml8f2f8/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Коринфар таб. пролонг. высвоб. п/о плен., 10 мг, 100 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 142 ₽
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  • Коринфар Ретард таб. пролонг. действ. п/о плен., 20 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-pwzygvutc8/toggleWishlist":{"skuId":"334530461","productId":1401075854,"offerId":"zNRCsd_EVQ-Ts_saxduwKQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQzPHXy4CxisJDEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIjvGKnAUQnY/CnwEY1v2NByDX3MEH","sign":"lBx1oXY5RemTPpy0n5CJAtGBUfsC/kQRt4VA2OUq5wE="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-pwzygvutc8/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Коринфар Ретард таб. пролонг. действ. п/о плен., 20 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 114 ₽
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  • Лориста таб. п/о плен., 25 мг, 30 шт.
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    Лориста таб. п/о плен., 25 мг, 30 шт.

    Рейтинг товара: 4.9 из 5
    на основе 34 оценки
    Цена 119 ₽
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  • Кордафлекс таб. таб. пролонг. действ., 20 мг, 60 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-58zmy8i7icg/toggleWishlist":{"skuId":"265149460","productId":1401075831,"offerId":"_5kUUaxLmYBmPfvmCZbCGg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQzPHXy4CxisJDEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI9/CKnAUQlLi3fhiS3dAHINfcwQc=","sign":"bRgpUhASVCM4OQ6ZHP+6aBHOhOLZuiiC8fFhhvw7D/c="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-58zmy8i7icg/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Кордафлекс таб. таб. пролонг. действ., 20 мг, 60 шт.

    Рейтинг товара: 4.8 из 5
    на основе 5 оценок
    Цена 152 ₽
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  • Кордипин ХЛ таб. с модиф. высвоб. п/о плен., 40 мг, 20 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-kpwi6a6t3td/toggleWishlist":{"skuId":"265313415","productId":1780857817,"offerId":"_QcsGDj0b4glISWcX_Ff2g","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQzPHXy4CxisJDEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI2feW0QYQh7nBfhi21YcEINfcwQc=","sign":"B7XEZ+19yI5AzswTepUXAZsq8noLjxPTY89oxPl5L8g="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-kpwi6a6t3td/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Кордипин ХЛ таб. с модиф. высвоб. п/о плен., 40 мг, 20 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 170 ₽
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  • Нифедипин таб. п/о плен., 10 мг, 50 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ygraaxdow69/toggleWishlist":{"skuId":"228057965","productId":1778174054,"offerId":"PbV8VGvKCy34vhpJPndDxQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQzPHXy4CxisJDEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI5pDzzwYQ7cbfbBjX8c8GINfcwQc=","sign":"HPh8xVDJP52cLfh2gR3yzNKYWWK1Jl0kWWYRYy7Ltc4="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ygraaxdow69/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Нифедипин таб. п/о плен., 10 мг, 50 шт.

    Рейтинг товара: 5 из 5
    на основе 6 оценок
    Цена 43 ₽
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  • Раунатин таб. п/о, 2 мг, 50 шт.
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    Раунатин таб. п/о, 2 мг, 50 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 196 ₽
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  • Эгилок таб., 25 мг, 60 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-3yxsf8qu6j2/toggleWishlist":{"skuId":"227814603","productId":1401075630,"offerId":"sR7D5jAQBihSmDEFS-X4Yw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQzPHXy4CxisJDEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIru+KnAUQy9nQbBiS3dAHINfcwQc=","sign":"3aHT305a6RJQ8J7e9Wzv7LGpdeQvXaRLlgZ00flArCM="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-3yxsf8qu6j2/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Эгилок таб., 25 мг, 60 шт.

    Рейтинг товара: 4.9 из 5
    на основе 12 оценок
    Цена 79 ₽
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  • Капотен таб., 25 мг, 28 шт.
    –14 %
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    Капотен таб., 25 мг, 28 шт.

    Рейтинг товара: 4.9 из 5
    на основе 13 оценок
    Цена 213 ₽ вместо 249
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  • Дибазол-УБФ таб., 0.02 г, 10 шт.
    –1 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-rbfk92jv0pd/toggleWishlist":{"skuId":"228007755","productId":1401075726,"offerId":"tmtPDfzG5op3dNS5ILGU7w","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQzPHXy4CxisJDEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIjvCKnAUQy77cbBiK49AHINfcwQc=","sign":"PM7J+pDl19fUWj4WjwT7G1XFHxboj3/AfdTaBYluhCw="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-rbfk92jv0pd/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Дибазол-УБФ таб., 0.02 г, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 5 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 82 ₽ вместо 83
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Инструкция

Показания к применению

— хроническая стабильная стенокардия (стенокардия напряжения);
— стенокардия Принцметала (вариантная стенокардия);
— артериальная гипертензия.

Противопоказания

— артериальная гипотензия (систолическое АД ниже 90 мм рт. ст.);
— кардиогенный шок, коллапс;
— хроническая сердечная недостаточность в стадии декомпенсации;
— выраженный аортальный стеноз;
— нестабильная стенокардия;
— острый инфаркт миокарда (первые 4 недели);
— совместное применение с рифампицином;
— I триместр беременности;
— период лактации (грудного вскармливания);
— повышенная чувствительность к нифедипину и другим производным 1,4-дигидропиридина или к другим компонентам препарата.
С осторожностью: стеноз митрального клапана, гипертрофическая обструктивная кардиомиопатия, выраженная брадикардия или тахикардия, СССУ, злокачественная артериальная гипертензия, гиповолемия, тяжелые нарушения мозгового кровообращения, инфаркт миокарда с левожелудочковой недостаточностью, непроходимость ЖКТ, почечная и печеночная недостаточность, гемодиализ (из-за риска возникновения артериальной гипотензии), II и III триместры беременности, детский и подростковый возраст до 18 лет (эффективность и безопасность не установлены), одновременный прием бета-адреноблокаторов, дигоксина.

Способ применения и дозы

Внутрь после еды, не разжевывая и запивая достаточным количеством жидкости. Доза препарата подбирается врачом индивидуально в соответствии с тяжестью заболевания и чувствительностью больного к препарату. Для пациентов с сопутствующими тяжелыми цереброваскулярными заболеваниями и у пациентов пожилого возраста дозу препарата следует уменьшить.
Одновременный прием пищи задерживает, но не уменьшает всасывание нифедипина из ЖКТ.
Хроническая стабильная и вазоспастическая стенокардия
Начальная доза - 10 мг (1 таб.) 2-3 раза/сут. При недостаточно выраженном клиническом эффекте дозу препарата постепенно увеличивают до 2 таб. (20 мг) 1-2 раза/сут. Максимальная суточная доза - 40 мг (4 таб./сут).
Эссенциальная гипертензия
Средняя суточная доза - 10 мг (1 таб.) 2-3 раза/сут.
При недостаточно выраженном клиническом эффекте возможно постепенное увеличение дозы препарата до 20 мг (2 таб.) 2 раза/сут. Максимальная суточная доза - 40 мг (4 таб./сут).
При 2-кратном назначении минимальный интервал между приемами препарата должен составлять не менее 4 ч.
Длительность курса лечения определяется лечащим врачом.
Полная инструкция
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Коринфар таб. пролонг. действ.п.п.о.
Коринфар таб. пролонг. действ.п.п.о., 10 мг, 50 шт.
5.0
(2)
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2 вопроса
Инструкция

75 ₽

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5.0
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У продавца:2 оценки·1 отзыв
У всех продавцов:7 оценок·4 отзыва
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5 месяцев назад • Имя скрыто • Куплен на Маркете
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