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Левофлоксацин гл. капли фл., 0,5%, 5 мл

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Нет отзывов
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Коротко о товаре

Артикул Маркета
584798313
Тип препарата
Назначение
Действующее вещество
Возраст
от 1 года
Инструкция
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Препарат применяют в виде инстилляций.\u003Cbr\u003EПо 1-2 капле в пораженный глаз (а) каждые 2 часа (до 8 раз в сутки) в период бодрствования в течение первых 2-х суток, затем 4 раза в сутки с 3 по 5-й дни.\u003Cbr\u003EДлительность курса лечения определяется тяжестью состояния, его клиническими и бактериологическими особенностями. Средняя продолжительность курса терапии составляет 5 дней, при отсутствии терапевтического эффекта к концу терапии рекомендуется пересмотреть диагноз и выбор лечебной тактики.\u003Cbr\u003EДля предотвращения микробной контаминации кончика флакона-капельницы и препарата необходимо избегать их соприкосновения с веками, кожей окологлазничной области и другими поверхностями.\u003Cbr\u003EПри одновременном применении нескольких офтальмологических препаратов для местного применения необходимо соблюдать 15-минутный интервал между инстилляциями, глазные мази следует применять в последнюю очередь.\u003Cbr\u003EВ целях предотвращения абсорбции препарата через слизистую оболочку носа, необходимо пальцем пережать носослезный канал на 2-3 минуты после инстилляций."},{"name":"Побочные действия","value":"Нежелательные реакции (HP) распределены в соответствии с классификацией поражения органов и систем органов согласно словарю MedDRA и частотой развития HP ВОЗ: очень часто (≥ 1/10), часто (≥ 1/100 и \u003C 1/10), нечасто (≥ 1/1000 и \u003C 1/100), редко (≥ 1/10000 и \u003C 1/1000), очень редко (\u003C 1/10000), частота неизвестна (по имеющимся данным установить частоту возникновения не представляется возможным).\u003Cbr\u003EНарушения со стороны иммунной системы\u003Cbr\u003EРедко: системные аллергические реакции, в том числе кожная сыпь.\u003Cbr\u003EОчень редко: анафилактический шок.\u003Cbr\u003EНарушения со стороны нервной системы\u003Cbr\u003EНечасто: головная боль, нарушение вкуса.\u003Cbr\u003EНарушения со стороны органа зрения\u003Cbr\u003EЧасто: жжение в глазу, снижение зрения, нитчатое слизистое отделяемое в конъюнктивальной полости.\u003Cbr\u003EНечасто: хемоз, конъюнктивальная инъекция, папиллярный конъюнктивит, отек век, эритема век, дискомфорт в глазу, зуд в глазу, боль в глазу, синдром «сухого» глаза, светобоязнь.\u003Cbr\u003EНарушения со стороны дыхательной системы, органов грудной клетки и средостения\u003Cbr\u003EЧасто: фарингит.\u003Cbr\u003EНечасто: ринит.\u003Cbr\u003EОчень редко: отек гортани.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта\u003Cbr\u003EЧасто: диарея, диспепсия, тошнота\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей\u003Cbr\u003EЧасто не известна: кожная сыпь, контактная экзема\u003Cbr\u003EПрофиль нежелательных явлений при применении препарата в педиатрической популяции сопоставим со взрослой популяцией.\u003Cbr\u003EПоскольку препарат содержит бензалкония хлорид, возможно развитие контактного дерматита и раздражение глаза."},{"name":"Фармакологическое действие","value":"Левофлоксацин - это L-изомер рацемической лекарственной субстанции офлоксацина. Антибактериальная активность офлоксацина относится, главным образом, к L-изомеру.\u003Cbr\u003EКак антибактериальный препарат класса фторхинолонов, левофлоксацин блокирует ДНК-гиразу (топоизомеразу II) и топоизомеразу IV, нарушает суперспирализацию и сшивку разрывов ДНК (дезоксирибонуклеиновой кислоты), подавляет синтез ДНК, вызывает глубокие морфологические изменения в цитоплазме, клеточной стенке и мембранах.\u003Cbr\u003EМеханизм развития резистентности\u003Cbr\u003EРезистентность к левофлоксацину может развиваться, в первую очередь, по двум основным механизмам, а именно: снижение внутриклеточной концентрации препарата или изменения в мишенях действия препарата. Изменение мишеней - двух бактериальных ферментов ДНК-гиразы и топоизомеразы IV являются результатом мутаций в хромосомных генах, кодирующих ДНК-гиразу (gyrA и gyrB) и топоизомеразу IV (рагС и parE; grlA и grlB у Staphylococcus aureus).\u003Cbr\u003EУстойчивость препарата вследствие низкой внутриклеточной концентрации развивается в результате изменения системы пориновых каналов наружной мембраны клетки, что приводит к уменьшению поступления фторхинолона в грамотрицательные бактерии, или от эффлюксных насосов.\u003Cbr\u003EЭффлюкс-опосредованная устойчивость описана в отношении pneumococci (PmrA), staphylococci (NorА), анаэробных и грамотрицательных бактерий.\u003Cbr\u003EПлазмид-опосредованная устойчивость к хинолонам (определенная на основе гена qnr) была обнаружена в отношении Klebsiella pneumoniae и Escherichia coli. Возможно развитие перекрестной резистентности между фторхинолонами. Единичные мутации могут не приводить к клинической устойчивости, но множественные мутации вызывают клиническую устойчивость ко всем препаратам, входящим в класс фторхинолонов. Подверженные изменениям порины внешних мембран и системы эффлюкса могут иметь широкую субстратную специфичность, затрагивая несколько классов антибактериальных агентов и приводя к множественной резистентности.\u003Cbr\u003EУстановлена in vitro и подтверждена в клинических исследованиях эффективность в отношении грамположительных аэробов - Enterococcus faecalis, Staphylococcus aureus (метициллин-чувствительные штаммы), Staphylococcus epidermidis (метициллин-чувствительные штаммы), Staphylococcus saprophyticus, Streptococcus pneumoniae (в т. ч. мультирезистентные штаммы - MDRSP), Streptococcus pyogenes; грамотрицательных аэробов - Enterobacter cloacae, Escherichia coli, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Legionella pneumophila, Moraxella catarrhalis, Proteus mirabilis, Pseudomonas aeruginosa, Serratia marcescens и других микроорганизмов - Chlamydia pneumoniae, Mycoplasma pneumoniae.\u003Cbr\u003EВ отношении большинства (≥ 90%) штаммов следующих микроорганизмов in vitro установлены минимальные подавляющие концентрации левофлоксацина (2 мкг/мл и менее), однако эффективность и безопасность клинического применения левофлоксацина в терапии инфекций, вызванных этими возбудителями, не установлена в адекватных и хорошо контролируемых исследованиях: грамположительные аэробы - Staphylococcus haemolyticus, Streptococcus (группа C/F), Streptococcus (группа G), Streptococcus agalactiae, Streptococcus milleri, Streptococcus viridans; грамотрицательные аэробы - Acinetobacter Iwoffii, Acinetobacter baumannii, Bordetella pertussis, Citrobacter (diversus) koseri, Citrobacter freundii, Enterobacter aerogenes, Enterobacter sakazakii, Klebsiella oxytoca, Morganella morganii, Pantoea (Enterobacter) agglomerans, Proteus vulgaris, Providencia rettgeri, Providencia stuartii, Pseudomonas fluorescens; грамположительные анаэробы - Clostridium perfringens.\u003Cbr\u003EЧувствительные микроорганизмы: аэробные грамположительные микроорганизмы - Corynebacterium diphtheriae, Enterococcus spp., в том числе Enterococcus faecalis, Listeria monocytogenes, Staphylococcus spp. (коагулазоотрицательные метициллин-чувствительные/ лейкотоксинсодержащие/ умеренно чувствительные штаммы), в том числе Staphylococcus aureus (метициллин-чувствительные штаммы), Staphylococcus epidermidis (метициллин-чувствительные штаммы), Streptococcus spp. групп С и G, Streptococcus agalactiae, Streptococcus pneumonia (пенициллин-чувствительные/умеренно чувствительные/ резистентные штаммы), Streptococcus pyogenes, Streptococcus spp. группы viridans (пенициллин-чувствительные/ резистентные штаммы); аэробные грамотрицательные микроорганизмы - Acinetobacter spp., в том числе Acinetobacter baumannii, Acinetobacillus actinomycetecomitans, Citrobacter freundii, Eikenella corrodens, Enterobacter spp., в том числе Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter cloacae, Escherichia coli, Gardnerella vaginalis, Haemophilus ducreyi, Haemophilus influenzae (ампициллин-чувствительные/ резистентные штаммы), Haemophilus parainfluenzae, Helicobacter pylori, Klebsiella spp., в том числе Klebsiella oxytoca, Klebsiella pneumoniae, Moraxella catarrhalis (продуцирующие и неиродуцирующие бета-лактамазу штаммы), Morganella morganii, Neisseria gonorrhoeae (продуцирующие и непродуцирующие пенициллиназу штаммы), Neisseria meningitidis, Pasteurella spp., в том числе Pasteurella canis, Pasteurella dagmatis, Pasteurella multocida, Proteus vulgaris, Providencia spp., в том числе Providencia rettgeri, Providencia stuartii, Pseudomonas spp., в том числе Pseudomonas aeruginosa, Serratia spp., в том числе Serratia marcescens, Salmonella spp.; анаэробные микроорганизмы - Bacteroides fragilis, Bifidobacterium spp., Clostridium perfringens, Fusobacterium spp., Peptostreptococcus spp., Propionibacterium spp., Veilonella spp.; другие микроорганизмы - Bartonella spp., Chlamydia pneumoniae, Chlamydia psittaci, Chlamydia trachomatis, Legionella pneumophila, Legionella spp., Mycobacterium leprae, Mycobacterium tuberculosis, Mycoplasma hominis, Mycoplasma pneumoniae, Rickettsia spp., Ureaplasma urealyticum.\u003Cbr\u003EУмеренно чувствительные микроорганизмы (МПК более 4 мг/л): аэробные грамположительные микроорганизмы - Corynebacterium urealyticum, Corynebacterium xerosis, Enterococcus faecium, Staphylococcus epidermidis (метициллин-резистентные штаммы), Staphylococcus haemolyticus (метициллин-резистентные штаммы); аэробные грамотрицательные микроорганизмы - Burkhoideria cepacia, Campylobacter jejuni, Campylobacter coli; анаэробные микроорганизмы - Bacteroides thetaiotaomicron, Bacteroides vulgatus, Bacteroides ovatus, Prevotella spp., Porphyromonas spp.\u003Cbr\u003EРезистентные микроорганизмы (МПК более 8 мг/мл): аэробные грамположительные микроорганизмы - Corynebacterium jeikeium, Staphylococcus aureus (метициллин-резистентные штаммы), прочие Staphylococcus spp. (коагулазоотрицательные метициллин-резистентные штаммы); аэробные грамотрицателъные микроорганизмы - Alcaligenes xylosoxidane; другие микроорганизмы - Mycobacterium avium."},{"name":"Фармакологическая группа","value":"противомикробное средство - фторхинолон"},{"name":"Форма выпуска","value":"капли"},{"name":"Способ применения/введения","value":"конъюктивальный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["35947170:36763746"]}}},{"name":"Минимальный возраст применения","value":"от 1 года"},{"name":"Условия хранения","value":"В защищенном от света месте, при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Общее количество левофлоксацина, содержащееся в одном флаконе глазных капель, слишком мало, чтобы вызвать токсические реакции даже после случайного приема внутрь. После местного применения избыточной дозы препарата глаз следует промыть чистой (водопроводной) водой комнатной температуры."},{"name":"Применение при беременности и кормлении грудью","value":"Беременность\u003Cbr\u003EНет достаточных данных о применении левофлоксацина у беременных женщин. Результаты доклинических исследований не указывают на прямой или косвенный неблагоприятный эффект в отношении токсического воздействия на репродуктивную функцию и внутриутробное развитие. Потенциальный риск препарата для людей неизвестен. Глазные капли левофлоксацин можно применять во время беременности, если потенциальная польза для матери превышает возможный риск для плода.\u003Cbr\u003EПериод грудного вскармливания\u003Cbr\u003EВ малых концентрациях левофлоксацин попадает в грудное молоко. Маловероятно влияние левофлоксацина на ребенка, находящегося на грудном вскармливании, при его применении матерью в терапевтических дозах, тем не менее нельзя исключить риск развития нежелательных реакций у ребенка. Необходимо прекратить грудное вскармливание или прекратить/воздержаться от терапии левофлоксацином, принимая во внимание преимущества грудного вскармливания для ребенка и пользу терапии для матери."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Препарат не оказывает существенного влияния на способность управлять транспортными средствами, механизмами. Непосредственно после инстилляции возможно временное затуманивание зрения, в связи с чем не рекомендуется управлять транспортными средствами и заниматься другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций, до восстановления четкости зрительного восприятия."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EДетский возраст.\u003Cbr\u003EЕсли препарат применяется для лечения детей, перед использованием обязательно проконсультируйтесь с врачом.\u003Cbr\u003EПрепарат нельзя вводить субконъюнктивалыю и в переднюю камеру глаза.\u003Cbr\u003EПрепарат не следует применять во время ношения гидрофильных (мягких) контактных линз в связи с наличием в нем консерванта бензалкония хлорида, который может абсорбироваться контактными линзами и оказывать неблагоприятное воздействие на ткани глаза, а также вызывать изменение цвета контактных линз.\u003Cbr\u003EПри длительном лечении левофлоксацином (как и другими антибиотиками) возможен избыточный рост нечувствительных микроорганизмов, в том числе грибковой флоры.\u003Cbr\u003EВ случае ухудшения течения заболевания или отсутствия улучшения при применении левофлоксацина, необходимо отменить терапию левофлоксацином и перейти на терапию антибактериальными препаратами других групп, с проведением расширенного офтальмологического обследования, включающего биомикроскопию и флюоресцеиновый тест. Сведения об эффективности и безопасности применения левофлоксацина в терапии язв роговицы отсутствуют.\u003Cbr\u003EВ ходе клинических исследований не отмечено образования преципитатов роговицы.\u003Cbr\u003EПри длительном применении препарата возможно развитие точечной/язвенной токсической кератопатии у пациентов с синдромом «сухого» глаза или сопутствующими заболеваниями роговицы. Необходим тщательный контроль состояния роговицы таких пациентов в период лечения препаратом."},{"name":"Взаимодействие","value":"Специальных исследований взаимодействия левофлоксацина в виде глазных капель не проводилось. Так как максимальная концентрация левофлоксацина в плазме после местного применения в 1000 раз меньше, чем при пероральном приеме, эффекты взаимодействия с другими лекарственными средствами маловероятны."},{"name":"Регистрационный номер","value":"ЛП-007462"},{"name":"Дата государственной регистрации","value":"30.09.2021"},{"name":"Владелец регистрационного удостоверения","value":"Дальхимфарм","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["34324371:35649313","7893318:13877405"]}}},{"name":"Изготовитель","value":"Дальхимфарм"},{"name":"Фасовщик","value":"Дальхимфарм"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Левофлоксацин","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["17796364:18036870"]}}},{"name":"Срок годности","value":"1 г."}]}},"fullSpecsGrouped":{"4325037717336712872":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"глаза"},{"name":"Назначение","value":"бактериальные инфекции глаз"},{"name":"Показания к применению","value":"Лечение поверхностных бактериальных инфекций глаза, вызванных чувствительными микроорганизмами, у взрослых и детей старше 1 года.\u003Cbr\u003EПрофилактика осложнений после хирургических и лазерных операций на глазу."},{"name":"Противопоказания","value":"Гиперчувствительность к левофлоксацину или к любому из компонентов лекарственного препарата, а также к другим хинолонам.\u003Cbr\u003EДетский возраст до 1 года."},{"name":"Состав","value":"Действующее вещество: левофлоксацина гемигидрата - 5,12 мг в пересчете на левофлоксацин - 5 мг\u003Cbr\u003EВспомогательные вещества: натрия хлорид - 9 мг\u003Cbr\u003Eбензалкония хлорид - 0,05 мг\u003Cbr\u003Eхлористоводородной кислоты раствор 1 М или натрия гидроксида раствор 1 М - до pH 6,0-7,0 вода для инъекций - до 1 мл."},{"name":"Действующее вещество","value":"Левофлоксацин"},{"name":"Способ применения и дозы","value":"Местно. Препарат применяют в виде инстилляций.\u003Cbr\u003EПо 1-2 капле в пораженный глаз (а) каждые 2 часа (до 8 раз в сутки) в период бодрствования в течение первых 2-х суток, затем 4 раза в сутки с 3 по 5-й дни.\u003Cbr\u003EДлительность курса лечения определяется тяжестью состояния, его клиническими и бактериологическими особенностями. Средняя продолжительность курса терапии составляет 5 дней, при отсутствии терапевтического эффекта к концу терапии рекомендуется пересмотреть диагноз и выбор лечебной тактики.\u003Cbr\u003EДля предотвращения микробной контаминации кончика флакона-капельницы и препарата необходимо избегать их соприкосновения с веками, кожей окологлазничной области и другими поверхностями.\u003Cbr\u003EПри одновременном применении нескольких офтальмологических препаратов для местного применения необходимо соблюдать 15-минутный интервал между инстилляциями, глазные мази следует применять в последнюю очередь.\u003Cbr\u003EВ целях предотвращения абсорбции препарата через слизистую оболочку носа, необходимо пальцем пережать носослезный канал на 2-3 минуты после инстилляций."},{"name":"Побочные действия","value":"Нежелательные реакции (HP) распределены в соответствии с классификацией поражения органов и систем органов согласно словарю MedDRA и частотой развития HP ВОЗ: очень часто (≥ 1/10), часто (≥ 1/100 и \u003C 1/10), нечасто (≥ 1/1000 и \u003C 1/100), редко (≥ 1/10000 и \u003C 1/1000), очень редко (\u003C 1/10000), частота неизвестна (по имеющимся данным установить частоту возникновения не представляется возможным).\u003Cbr\u003EНарушения со стороны иммунной системы\u003Cbr\u003EРедко: системные аллергические реакции, в том числе кожная сыпь.\u003Cbr\u003EОчень редко: анафилактический шок.\u003Cbr\u003EНарушения со стороны нервной системы\u003Cbr\u003EНечасто: головная боль, нарушение вкуса.\u003Cbr\u003EНарушения со стороны органа зрения\u003Cbr\u003EЧасто: жжение в глазу, снижение зрения, нитчатое слизистое отделяемое в конъюнктивальной полости.\u003Cbr\u003EНечасто: хемоз, конъюнктивальная инъекция, папиллярный конъюнктивит, отек век, эритема век, дискомфорт в глазу, зуд в глазу, боль в глазу, синдром «сухого» глаза, светобоязнь.\u003Cbr\u003EНарушения со стороны дыхательной системы, органов грудной клетки и средостения\u003Cbr\u003EЧасто: фарингит.\u003Cbr\u003EНечасто: ринит.\u003Cbr\u003EОчень редко: отек гортани.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта\u003Cbr\u003EЧасто: диарея, диспепсия, тошнота\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей\u003Cbr\u003EЧасто не известна: кожная сыпь, контактная экзема\u003Cbr\u003EПрофиль нежелательных явлений при применении препарата в педиатрической популяции сопоставим со взрослой популяцией.\u003Cbr\u003EПоскольку препарат содержит бензалкония хлорид, возможно развитие контактного дерматита и раздражение глаза."},{"name":"Фармакологическое действие","value":"Левофлоксацин - это L-изомер рацемической лекарственной субстанции офлоксацина. Антибактериальная активность офлоксацина относится, главным образом, к L-изомеру.\u003Cbr\u003EКак антибактериальный препарат класса фторхинолонов, левофлоксацин блокирует ДНК-гиразу (топоизомеразу II) и топоизомеразу IV, нарушает суперспирализацию и сшивку разрывов ДНК (дезоксирибонуклеиновой кислоты), подавляет синтез ДНК, вызывает глубокие морфологические изменения в цитоплазме, клеточной стенке и мембранах.\u003Cbr\u003EМеханизм развития резистентности\u003Cbr\u003EРезистентность к левофлоксацину может развиваться, в первую очередь, по двум основным механизмам, а именно: снижение внутриклеточной концентрации препарата или изменения в мишенях действия препарата. Изменение мишеней - двух бактериальных ферментов ДНК-гиразы и топоизомеразы IV являются результатом мутаций в хромосомных генах, кодирующих ДНК-гиразу (gyrA и gyrB) и топоизомеразу IV (рагС и parE; grlA и grlB у Staphylococcus aureus).\u003Cbr\u003EУстойчивость препарата вследствие низкой внутриклеточной концентрации развивается в результате изменения системы пориновых каналов наружной мембраны клетки, что приводит к уменьшению поступления фторхинолона в грамотрицательные бактерии, или от эффлюксных насосов.\u003Cbr\u003EЭффлюкс-опосредованная устойчивость описана в отношении pneumococci (PmrA), staphylococci (NorА), анаэробных и грамотрицательных бактерий.\u003Cbr\u003EПлазмид-опосредованная устойчивость к хинолонам (определенная на основе гена qnr) была обнаружена в отношении Klebsiella pneumoniae и Escherichia coli. Возможно развитие перекрестной резистентности между фторхинолонами. Единичные мутации могут не приводить к клинической устойчивости, но множественные мутации вызывают клиническую устойчивость ко всем препаратам, входящим в класс фторхинолонов. Подверженные изменениям порины внешних мембран и системы эффлюкса могут иметь широкую субстратную специфичность, затрагивая несколько классов антибактериальных агентов и приводя к множественной резистентности.\u003Cbr\u003EУстановлена in vitro и подтверждена в клинических исследованиях эффективность в отношении грамположительных аэробов - Enterococcus faecalis, Staphylococcus aureus (метициллин-чувствительные штаммы), Staphylococcus epidermidis (метициллин-чувствительные штаммы), Staphylococcus saprophyticus, Streptococcus pneumoniae (в т. ч. мультирезистентные штаммы - MDRSP), Streptococcus pyogenes; грамотрицательных аэробов - Enterobacter cloacae, Escherichia coli, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Legionella pneumophila, Moraxella catarrhalis, Proteus mirabilis, Pseudomonas aeruginosa, Serratia marcescens и других микроорганизмов - Chlamydia pneumoniae, Mycoplasma pneumoniae.\u003Cbr\u003EВ отношении большинства (≥ 90%) штаммов следующих микроорганизмов in vitro установлены минимальные подавляющие концентрации левофлоксацина (2 мкг/мл и менее), однако эффективность и безопасность клинического применения левофлоксацина в терапии инфекций, вызванных этими возбудителями, не установлена в адекватных и хорошо контролируемых исследованиях: грамположительные аэробы - Staphylococcus haemolyticus, Streptococcus (группа C/F), Streptococcus (группа G), Streptococcus agalactiae, Streptococcus milleri, Streptococcus viridans; грамотрицательные аэробы - Acinetobacter Iwoffii, Acinetobacter baumannii, Bordetella pertussis, Citrobacter (diversus) koseri, Citrobacter freundii, Enterobacter aerogenes, Enterobacter sakazakii, Klebsiella oxytoca, Morganella morganii, Pantoea (Enterobacter) agglomerans, Proteus vulgaris, Providencia rettgeri, Providencia stuartii, Pseudomonas fluorescens; грамположительные анаэробы - Clostridium perfringens.\u003Cbr\u003EЧувствительные микроорганизмы: аэробные грамположительные микроорганизмы - Corynebacterium diphtheriae, Enterococcus spp., в том числе Enterococcus faecalis, Listeria monocytogenes, Staphylococcus spp. (коагулазоотрицательные метициллин-чувствительные/ лейкотоксинсодержащие/ умеренно чувствительные штаммы), в том числе Staphylococcus aureus (метициллин-чувствительные штаммы), Staphylococcus epidermidis (метициллин-чувствительные штаммы), Streptococcus spp. групп С и G, Streptococcus agalactiae, Streptococcus pneumonia (пенициллин-чувствительные/умеренно чувствительные/ резистентные штаммы), Streptococcus pyogenes, Streptococcus spp. группы viridans (пенициллин-чувствительные/ резистентные штаммы); аэробные грамотрицательные микроорганизмы - Acinetobacter spp., в том числе Acinetobacter baumannii, Acinetobacillus actinomycetecomitans, Citrobacter freundii, Eikenella corrodens, Enterobacter spp., в том числе Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter cloacae, Escherichia coli, Gardnerella vaginalis, Haemophilus ducreyi, Haemophilus influenzae (ампициллин-чувствительные/ резистентные штаммы), Haemophilus parainfluenzae, Helicobacter pylori, Klebsiella spp., в том числе Klebsiella oxytoca, Klebsiella pneumoniae, Moraxella catarrhalis (продуцирующие и неиродуцирующие бета-лактамазу штаммы), Morganella morganii, Neisseria gonorrhoeae (продуцирующие и непродуцирующие пенициллиназу штаммы), Neisseria meningitidis, Pasteurella spp., в том числе Pasteurella canis, Pasteurella dagmatis, Pasteurella multocida, Proteus vulgaris, Providencia spp., в том числе Providencia rettgeri, Providencia stuartii, Pseudomonas spp., в том числе Pseudomonas aeruginosa, Serratia spp., в том числе Serratia marcescens, Salmonella spp.; анаэробные микроорганизмы - Bacteroides fragilis, Bifidobacterium spp., Clostridium perfringens, Fusobacterium spp., Peptostreptococcus spp., Propionibacterium spp., Veilonella spp.; другие микроорганизмы - Bartonella spp., Chlamydia pneumoniae, Chlamydia psittaci, Chlamydia trachomatis, Legionella pneumophila, Legionella spp., Mycobacterium leprae, Mycobacterium tuberculosis, Mycoplasma hominis, Mycoplasma pneumoniae, Rickettsia spp., Ureaplasma urealyticum.\u003Cbr\u003EУмеренно чувствительные микроорганизмы (МПК более 4 мг/л): аэробные грамположительные микроорганизмы - Corynebacterium urealyticum, Corynebacterium xerosis, Enterococcus faecium, Staphylococcus epidermidis (метициллин-резистентные штаммы), Staphylococcus haemolyticus (метициллин-резистентные штаммы); аэробные грамотрицательные микроорганизмы - Burkhoideria cepacia, Campylobacter jejuni, Campylobacter coli; анаэробные микроорганизмы - Bacteroides thetaiotaomicron, Bacteroides vulgatus, Bacteroides ovatus, Prevotella spp., Porphyromonas spp.\u003Cbr\u003EРезистентные микроорганизмы (МПК более 8 мг/мл): аэробные грамположительные микроорганизмы - Corynebacterium jeikeium, Staphylococcus aureus (метициллин-резистентные штаммы), прочие Staphylococcus spp. (коагулазоотрицательные метициллин-резистентные штаммы); аэробные грамотрицателъные микроорганизмы - Alcaligenes xylosoxidane; другие микроорганизмы - Mycobacterium avium."},{"name":"Фармакологическая группа","value":"противомикробное средство - фторхинолон"},{"name":"Форма выпуска","value":"капли"},{"name":"Способ применения/введения","value":"конъюктивальный"},{"name":"Минимальный возраст применения","value":"от 1 года"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"В защищенном от света месте, при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Общее количество левофлоксацина, содержащееся в одном флаконе глазных капель, слишком мало, чтобы вызвать токсические реакции даже после случайного приема внутрь. После местного применения избыточной дозы препарата глаз следует промыть чистой (водопроводной) водой комнатной температуры."},{"name":"Применение при беременности и кормлении грудью","value":"Беременность\u003Cbr\u003EНет достаточных данных о применении левофлоксацина у беременных женщин. Результаты доклинических исследований не указывают на прямой или косвенный неблагоприятный эффект в отношении токсического воздействия на репродуктивную функцию и внутриутробное развитие. Потенциальный риск препарата для людей неизвестен. Глазные капли левофлоксацин можно применять во время беременности, если потенциальная польза для матери превышает возможный риск для плода.\u003Cbr\u003EПериод грудного вскармливания\u003Cbr\u003EВ малых концентрациях левофлоксацин попадает в грудное молоко. Маловероятно влияние левофлоксацина на ребенка, находящегося на грудном вскармливании, при его применении матерью в терапевтических дозах, тем не менее нельзя исключить риск развития нежелательных реакций у ребенка. Необходимо прекратить грудное вскармливание или прекратить/воздержаться от терапии левофлоксацином, принимая во внимание преимущества грудного вскармливания для ребенка и пользу терапии для матери."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Препарат не оказывает существенного влияния на способность управлять транспортными средствами, механизмами. Непосредственно после инстилляции возможно временное затуманивание зрения, в связи с чем не рекомендуется управлять транспортными средствами и заниматься другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций, до восстановления четкости зрительного восприятия."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EДетский возраст.\u003Cbr\u003EЕсли препарат применяется для лечения детей, перед использованием обязательно проконсультируйтесь с врачом.\u003Cbr\u003EПрепарат нельзя вводить субконъюнктивалыю и в переднюю камеру глаза.\u003Cbr\u003EПрепарат не следует применять во время ношения гидрофильных (мягких) контактных линз в связи с наличием в нем консерванта бензалкония хлорида, который может абсорбироваться контактными линзами и оказывать неблагоприятное воздействие на ткани глаза, а также вызывать изменение цвета контактных линз.\u003Cbr\u003EПри длительном лечении левофлоксацином (как и другими антибиотиками) возможен избыточный рост нечувствительных микроорганизмов, в том числе грибковой флоры.\u003Cbr\u003EВ случае ухудшения течения заболевания или отсутствия улучшения при применении левофлоксацина, необходимо отменить терапию левофлоксацином и перейти на терапию антибактериальными препаратами других групп, с проведением расширенного офтальмологического обследования, включающего биомикроскопию и флюоресцеиновый тест. Сведения об эффективности и безопасности применения левофлоксацина в терапии язв роговицы отсутствуют.\u003Cbr\u003EВ ходе клинических исследований не отмечено образования преципитатов роговицы.\u003Cbr\u003EПри длительном применении препарата возможно развитие точечной/язвенной токсической кератопатии у пациентов с синдромом «сухого» глаза или сопутствующими заболеваниями роговицы. Необходим тщательный контроль состояния роговицы таких пациентов в период лечения препаратом."},{"name":"Взаимодействие","value":"Специальных исследований взаимодействия левофлоксацина в виде глазных капель не проводилось. Так как максимальная концентрация левофлоксацина в плазме после местного применения в 1000 раз меньше, чем при пероральном приеме, эффекты взаимодействия с другими лекарственными средствами маловероятны."},{"name":"Регистрационный номер","value":"ЛП-007462"},{"name":"Дата государственной регистрации","value":"30.09.2021"},{"name":"Владелец регистрационного удостоверения","value":"Дальхимфарм"},{"name":"Изготовитель","value":"Дальхимфарм"},{"name":"Фасовщик","value":"Дальхимфарм"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Левофлоксацин"},{"name":"Срок годности","value":"1 г."}]}],"transitionId":"tr_17458762262687875488"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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112 ₽

Скидка: 31%
–31 %
Вместо:162 ₽
  • 11-13 июня, самовывоз • 0 ₽
POLZAru
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  • Лидокаин гл. капли, 2%, 5 мл
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    Лидокаин гл. капли, 2%, 5 мл

    Цена 34 ₽
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  • Левофлоксацин гл. капли фл.-кап., 0,5%, 5 мл, 1 шт.
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    Левофлоксацин гл. капли фл.-кап., 0,5%, 5 мл, 1 шт.

    Рейтинг товара: 4.4 из 5
    на основе 12 оценок
    Цена 233 ₽
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  • Видисик гл. гель, 0.2%, 10 г
    ВАМ–7 %
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    Видисик гл. гель, 0.2%, 10 г

    Рейтинг товара: 4.7 из 5
    на основе 21 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 457 ₽ вместо 462
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  • Инокаин гл. капли, 0.4%, 5 мл
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    Инокаин гл. капли, 0.4%, 5 мл

    Рейтинг товара: 5 из 5
    на основе 5 оценок
    Цена 132 ₽
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  • Флоксал гл. мазь туба, 3 мг/г, 3 г
    –15 %
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    Флоксал гл. мазь туба, 3 мг/г, 3 г

    Рейтинг товара: 5 из 5
    на основе 11 оценок
    Цена 192 ₽ вместо 225
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  • Левофлоксацин-Оптик гл. капли фл., 0.5%, 5 мл
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    Левофлоксацин-Оптик гл. капли фл., 0.5%, 5 мл

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 143 ₽
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  • Полинадим гл. капли фл., 10 мл, 10 мл
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    Полинадим гл. капли фл., 10 мл, 10 мл

    Рейтинг товара: 5 из 5
    на основе 8 оценок
    Цена 251 ₽
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  • Гидрокортизон-ПОС гл. мазь, 2.5%, 2.5 г
    –1 %
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    Гидрокортизон-ПОС гл. мазь, 2.5%, 2.5 г

    Рейтинг товара: 4.8 из 5
    на основе 27 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 95 ₽ вместо 96
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  • Корнерегель гл. гель, 5%, 5 г
    ВАМ–11 %
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    Корнерегель гл. гель, 5%, 5 г

    Рейтинг товара: 4.7 из 5
    на основе 12 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 590 ₽ вместо 596
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  • Ципрофлоксацин-Оптик гл. капли фл-кап., 0.3%, 5 мл
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-h6hzw1zpkrk/toggleWishlist":{"skuId":"687078041","productId":1778174421,"offerId":"bipql8Ieetx4nSRt1KAhkw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ/ZS6kbfE59diEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYI1ZPzzwYQmfXPxwIY8vHPBiDc3MEH","sign":"h7aznJss4cuP1bEV570Nnl43swVt5RbWpQ7nmQR4v0c="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-h6hzw1zpkrk/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Ципрофлоксацин-Оптик гл. капли фл-кап., 0.3%, 5 мл

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 68 ₽
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  • Латанопрост гл. капли, 0,005%, 2.5 мл
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    Латанопрост гл. капли, 0,005%, 2.5 мл

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 281 ₽
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Инструкция

Показания к применению

Лечение поверхностных бактериальных инфекций глаза, вызванных чувствительными микроорганизмами, у взрослых и детей старше 1 года.
Профилактика осложнений после хирургических и лазерных операций на глазу.

Противопоказания

Гиперчувствительность к левофлоксацину или к любому из компонентов лекарственного препарата, а также к другим хинолонам.
Детский возраст до 1 года.

Способ применения и дозы

Местно. Препарат применяют в виде инстилляций.
По 1-2 капле в пораженный глаз (а) каждые 2 часа (до 8 раз в сутки) в период бодрствования в течение первых 2-х суток, затем 4 раза в сутки с 3 по 5-й дни.
Длительность курса лечения определяется тяжестью состояния, его клиническими и бактериологическими особенностями. Средняя продолжительность курса терапии составляет 5 дней, при отсутствии терапевтического эффекта к концу терапии рекомендуется пересмотреть диагноз и выбор лечебной тактики.
Для предотвращения микробной контаминации кончика флакона-капельницы и препарата необходимо избегать их соприкосновения с веками, кожей окологлазничной области и другими поверхностями.
При одновременном применении нескольких офтальмологических препаратов для местного применения необходимо соблюдать 15-минутный интервал между инстилляциями, глазные мази следует применять в последнюю очередь.
В целях предотвращения абсорбции препарата через слизистую оболочку носа, необходимо пальцем пережать носослезный канал на 2-3 минуты после инстилляций.
Полная инструкция
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Левофлоксацин гл. капли фл.
Левофлоксацин гл. капли фл., 0,5%, 5 мл
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