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Описание

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Вилдаглиптин-СЗ, 50 мг, 30 шт.

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5.0
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Коротко о товаре

Артикул Маркета
5109680113
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
{"widgets":{"@card/SpecsList":{"/content/page/fancyPage/productSpecsList":{"wrapperProps":{"margins":{"top":4,"bottom":4}},"specsLimit":5,"title":"Коротко о товаре","titleSize":"14","type":"minimal","offset":"s","isHealthCategory":true,"forceShowWidget":true,"withFridge":true}}},"meta":{"/content/page/fancyPage/productSpecsList":{"name":"@card/SpecsList"}},"collections":{"minimalSpecs":{"10663102356875382904":{"specItems":[{"name":"Артикул Маркета","value":"5109680113","withCopyValueButton":true},{"name":"тип препарата","value":"рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"sredstva-ot-sakharnogo-diabeta","categoryId":"15756510","navnodeId":"72472","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"назначение","value":"сахарный диабет","transition":{"type":"list","params":{"categorySlug":"sredstva-ot-sakharnogo-diabeta","categoryId":"15756510","navnodeId":"72472","glfilters":["36476390:36618661"]}}},{"name":"действующее вещество","value":"Вилдаглиптин","transition":{"type":"list","params":{"categorySlug":"sredstva-ot-sakharnogo-diabeta","categoryId":"15756510","navnodeId":"72472","glfilters":["27144131:28710038"]}}},{"name":"возраст","value":"от 18 лет"},{"name":"форма выпуска","value":"таблетки"},{"name":"страна-производитель","value":"Россия"}]}},"compactSpecs":{"10663102356875382904":{"specItems":[{"name":"Артикул Маркета","value":"5109680113","withCopyValueButton":true},{"name":"Тип препарата","value":"Рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"sredstva-ot-sakharnogo-diabeta","categoryId":"15756510","navnodeId":"72472","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"Назначение","value":"Сахарный диабет","transition":{"type":"list","params":{"categorySlug":"sredstva-ot-sakharnogo-diabeta","categoryId":"15756510","navnodeId":"72472","glfilters":["36476390:36618661"]}}},{"name":"Действующее вещество","value":"Вилдаглиптин","transition":{"type":"list","params":{"categorySlug":"sredstva-ot-sakharnogo-diabeta","categoryId":"15756510","navnodeId":"72472","glfilters":["27144131:28710038"]}}},{"name":"Возраст","value":"От 18 лет"}]}},"fullSpecs":{"10663102356875382904":{"specItems":[{"name":"Тип препарата","value":"лекарственный препарат","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-sakharnogo-diabeta","categoryId":"15756510","navnodeId":"72472","glfilters":["34324371:35649313"]}}},{"name":"Рецептурный препарат","value":"да","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-sakharnogo-diabeta","categoryId":"15756510","navnodeId":"72472","glfilters":["27272850:1,0"]}}},{"name":"Органы и системы","value":"эндокринная система"},{"name":"Назначение","value":"сахарный диабет","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-sakharnogo-diabeta","categoryId":"15756510","navnodeId":"72472","glfilters":["36476390:36618661"]}}},{"name":"Показания к применению","value":"Сахарный диабет 2 типа: в качестве монотерапии в сочетании с диетотерапией и физическими упражнениями; в составе двухкомпонентной комбинированной терапии с метформином, производными сульфонилмочевины, тиазолидиндионом или с инсулином в случае неэффективности диетотерапии, физических упражнений и монотерапии этими препаратами."},{"name":"Противопоказания","value":"гиперчувствительность к вилдаглиптину и/или любому из вспомогательных веществ, перечисленных в разделе 6.1.;\n\u003Cbr\u003Eнаследственная непереносимость галактозы, дефицит лактазы, \u003Cbr\u003Eглюкозо-галактозная мальабсорбция (см. раздел 4.4.);\n\u003Cbr\u003Eбеременность, грудное вскармливание (в связи с недостатком соответствующих данных) (см. раздел 4.6.);\nсахарный диабет типа 1 (см. раздел 4.4.);\n\u003Cbr\u003Eострый или хронический метаболический ацидоз (включая диабетический кетоацидоз в сочетании с комой или без таковой). \u003Cbr\u003EДиабетический кетоацидоз должен корректироваться инсулинотерапией. Лактоацидоз (в т.ч. и в анамнезе) (см. раздел 4.4.);\n\u003Cbr\u003Eнарушения функции печени, включaя пациентов с повышенной активностью печеночных ферментов (АЛТ или АСТ в 3 и более раз выше верхней границы нормы (3×ВГН);\n\u003Cbr\u003Eхроническая сердечная недостаточность (ХСН) IV функционального класса (ФК) по функциональной классификации Нью-Йоркской кардиологической ассоциации NYHA (ввиду отсутствия данных клинических исследований о применении вилдаглиптина у этой группы пациентов);\n\u003Cbr\u003Eдетский возраст до 18 лет (эффективность и безопасность применения препарата не установлены)."},{"name":"Состав","value":"вилдаглиптин\t50 мг\n\u003Cbr\u003EВспомогательные вещества: целлюлоза микрокристаллическая 102, лактозы моногидрат (лактопресс) (сахар молочный) - 48 мг, карбоксиметилкрахмал натрия, магния стеарат."},{"name":"Действующее вещество","value":"Вилдаглиптин","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-sakharnogo-diabeta","categoryId":"15756510","navnodeId":"72472","glfilters":["27144131:28710038"]}}},{"name":"Способ применения и дозы","value":"Дозу препарата Вилдаглиптин-СЗ следует подбирать индивидуально, в зависимости от эффективности и переносимости.\n\n\u003Cbr\u003EРекомендуемая доза препарата Вилдаглиптин-СЗ 50 мг 1 или 2 раза в сутки.\n\n\u003Cbr\u003EМаксимальная суточная доза препарата составляет 100 мг.\nДозу 50 мг/сут следует принимать 1 раз в сутки утром, дозу 100 мг/сут следует делить на 2 приема — по 50 мг утром и вечером. В случае пропуска приема препарата следует принять пропущенную дозу как можно скорее. При этом следует избегать принятия удвоенной дозы в один день,\n\n\u003Cbr\u003EРекомендуемая доза препарата в монотерапии или в составе комбинированной терапии с метформином, тиазолидиндионом или инсулином (в комбинации с метформином или без метформина) составляет 50 или 100 мг/сут.\n\n\u003Cbr\u003EРекомендуемая доза препарата Вилдаглиптин-СЗ в составе двойной комбинированной терапии с препаратами сульфонилмочевины составляет 50 мг 1 раз в сутки утром. В этой популяции пациентов эффективность вилдаглиптина в дозе l00 мг/сут была сходной с таковой в дозе 50 мг/сут,\n\n\u003Cbr\u003EРекомендуемая доза препарата Вилдаглиптин-СЗ в составе тройной комбинированной терапии (вилдаглиптин + производные сульфонилмочевины + метформин) составляет 100 мг/сут.\n\n\u003Cbr\u003EЕсли цели гликемического контроля не достигнуты на фоне применения максимальной суточной дозы l00 мг, следует рассмотреть возможность добавления к терапии препаратом Вилдаглиптин-СЗ других гипогликемических препаратов, таких как метформин, производные сульфонилмочевины, тиазолидиндион или инсулин."},{"name":"Побочные действия","value":"Со стороны пищеварительной системы: иногда - запоры; редко - нарушения функции печени (включая гепатит) бессимптомного течения; при комбинации с инсулином часто - тошнота, метеоризм, ГЭРБ.\n\n\u003Cbr\u003EСо стороны ЦНС: часто - тремор, головокружение, головная боль.\n\n\u003Cbr\u003EСо стороны обмена веществ: часто - гипогликемия, увеличение массы тела.\n\n\u003Cbr\u003EАллергические реакции: редко - ангионевротический отек (чаще при комбинации с ингибиторами АПФ).\n\n\u003Cbr\u003EПрочие: часто - астения, периферические отеки."},{"name":"Фармакологическое действие","value":"Гипогликемическое средство. Вилдаглиптин - представитель класса стимуляторов островкового аппарата поджелудочной железы, селективно ингибирует фермент дипептидилпептидазу-4 (ДПП-4). Быстрое и полное ингибирование активности ДПП-4 (\u003E 90%) вызывает повышение как базальной, так и стимулированной приемом пищи секреции глюкагоноподобного пептида 1 типа (ГПП-1) и глюкозозависимого инсулинотропного полипептида (ГИП) из кишечника в системный кровоток в течение всего дня.\nУвеличивая уровни ГПП-1 и ГИП, вилдаглиптин вызывает повышение чувствительности β-клеток поджелудочной железы к глюкозе, что приводит к улучшению глюкозозависимой секреции инсулина. При применении вилдаглиптина в дозе 50-100 мг/сут у больных с сахарным диабетом 2 типа отмечается улучшение функции β-клеток поджелудочной железы. Степень улучшения функции β-клеток зависит от степени их исходного повреждения; так у лиц, не страдающих сахарным диабетом (с нормальным уровнем глюкозы в плазме крови) вилдаглиптин не стимулирует секрецию инсулина и не снижает уровень глюкозы.\nПовышая уровни эндогенного ГПП-1, вилдаглиптин увеличивает чувствительность α-клеток к глюкозе, что приводит к улучшению глюкозозависимой регуляции секреции глюкагона. Снижение уровня избыточного глюкагона во время еды, в свою очередь, вызывает уменьшение инсулинорезистентности.\nУвеличение соотношения инсулин/глюкагон на фоне гипергликемии, обусловленное повышением уровней ГПП-1 и ГИП, вызывает уменьшение продукции глюкозы печенью как в прандиальный период, так и после приема пищи, что приводит к снижению уровня глюкозы в плазме крови.\nКроме того, на фоне применения вилдаглиптина отмечается снижение уровня липидов в плазме крови, однако этот эффект не связан с его действием на ГПП-1 или ГИП и улучшением функции β-клеток поджелудочной железы.\nИзвестно, что повышение уровня ГПП-1 может приводить к замедлению опорожнения желудка, однако на фоне применения вилдаглиптина подобного эффекта не наблюдается.\nПри применении вилдаглиптина у 5795 больных с сахарным диабетом 2 типа в течение от 12 до 52 недель в качестве монотерапии или в комбинации с метформином, производными сульфонилмочевины, тиазолидиндионом, или инсулином отмечается достоверное длительное снижение концентрации гликированного гемоглобина (HbA1с) и глюкозы крови натощак."},{"name":"Фармакологическая группа","value":"гиполипидемические средства"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-sakharnogo-diabeta","categoryId":"15756510","navnodeId":"72472","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"Храните препарат при температуре ниже 25 °C.\n"},{"name":"Условия отпуска из аптеки","value":"по рецепту"},{"name":"Передозировка","value":"Симптомы: вилдаглиптин хорошо переносится при применении в дозе до 200 мг/сут. При применении препарата в дозе 400 мг/сут может наблюдаться боль в мышцах, редко — легкие и транзиторные парестезии, лихорадка, отеки и транзиторное повышение активности липазы (выше ВГН в 2 раза). При увеличении дозы вилдаглиптина до 600 мг/сут возможно развитие отеков конечностей, сопровождающихся парестезиями и повышением активности креатинфосфокиназы, С-реактивного белка и миоглобина, активности АСТ. Все симптомы передозировки и изменения лабораторных показателей обратимы после прекращения применения препарата.\n\n\u003Cbr\u003EЛечение: выведение препарата из организма с помощью диализа маловероятно. Однако основной гидролизный метаболит вилдаглиптина (LAY151) может быть удален из организма путем гемодиализа."},{"name":"Применение при беременности и кормлении грудью","value":"Адекватных и строго контролируемых клинических исследований безопасности применения вилдаглиптина при беременности и в период лактации не проводилось, поэтому не следует применять вилдаглиптин при беременности и в период грудного вскармливания.\n\n\u003Cbr\u003EПри нарушениях обмена глюкозы у беременных женщин отмечается повышение риска развития врожденных аномалий, а также частоты неонатальной заболеваемости и смертности.\nНеизвестно, выделяется ли вилдаглиптин с грудным молоком у человека."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Если у Вас во время приема препарата Вилдаглиптин-СЗ отмечается головокружение, Вы должны воздержаться от управления транспортными средствами и работы с механизмами до исчезновения головокружения."},{"name":"Особые указания","value":"Не рекомендуется применять у пациентов с тяжелыми нарушениями функции печени, в т.ч. при повышении активности АЛТ или АСТ \u003E 2.5 раза выше ВГН.\n\n\u003Cbr\u003EНе рекомендуется применять у пациентов с умеренными или тяжелыми нарушениями функции почек (включая терминальную стадию почечной недостаточности и необходимостью проведения гемодиализа), т.к. данные о безопасности применения у данной категории пациентов ограничены.\n\n\u003Cbr\u003EПеред началом лечения, а также регулярно (1 раз в 3 месяца) в ходе первого года лечения, рекомендуется определять биохимические показатели функции печени. В случае выявления повышенной активности аминотрансфераз, этот результат следует подтвердить повторным исследованием, а затем регулярно проводить определение биохимических показателей функции печени до тех пор, пока они не нормализуются. Если превышение активности АСТ или АЛТ в 3 раза и более ВГН подтверждено повторным исследованием, то вилдаглиптин рекомендуется отменить.\n\n\u003Cbr\u003EПри развитии желтухи или других признаков нарушения функции печени терапию вилдаглиптином следует немедленно прекратить. После нормализации показателей функции печени лечение возобновлять нельзя.\n\n\u003Cbr\u003EПри необходимости инсулинотерапии вилдаглиптин применяют только в комбинации с инсулином.\nВилдаглиптин не следует применять для лечения сахарного диабета 1 типа или для лечения диабетического кетоацидоза."},{"name":"Взаимодействие","value":"Вилдаглиптин обладает низким потенциалом лекарственного взаимодействия. Поскольку вилдаглиптин не является субстратом ферментов цитохрома Р450 (СYР), а также не ингибирует и не индуцирует эти ферменты, взаимодействие вилдаглиптина с лекарственными препаратами, которые являются субстратами, ингибиторами или индукторами Р450 (СYР), маловероятно. При одновременном применении вилдаглиптин также не влияет на скорость метаболизма препаратов, являющихся субстратами ферментов: СYР1A2, СYР2С8, СYР2С9, CYP2C19, СYР2D6 и СYР3А4/5.\n\nКлинически значимого взаимодействия вилдаглиптина с препаратами, наиболее часто используемыми при лечении СД типа 2 (глибенкламидом, пиоглитазоном, метформином) или обладающими узким терапевтическим диапазоном (амлодипином, дигоксином, рамиприлом, симвастатином, валсартаном, варфарином), не установлено. Тиазиды, ГКС, препараты гормонов щитовидной железы, симпатомиметики моryт снижать гипогликемическое действие вилдаглиптина, как и других пероральных противодиабетических препаратов. Частота развития ангионевротического отека была выше при одновременном применении вилдаглиптина с ингибиторами АПФ, при этом была сходной с таковой в контрольной группе. В большинстве случаев ангионевротический отек был средней степени тяжести и разрешался самостоятельно в ходе продолжения терапии вилдаглиптином."},{"name":"Источник","value":"\u003Ca href=\"https://www.vidal.ru\" target=\"_blank\"\u003EСправочник лекарственных препаратов Видаль<\u002Fa\u003E"},{"name":"Регистрационный номер","value":"ЛП-№(000907)-(РГ-RU)"},{"name":"Дата государственной регистрации","value":"20.06.2022"},{"name":"Владелец регистрационного удостоверения","value":"Северная Звезда","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-sakharnogo-diabeta","categoryId":"15756510","navnodeId":"72472","glfilters":["34324371:35649313","7893318:16002862"]}}},{"name":"Изготовитель","value":"Северная Звезда"},{"name":"Фасовщик","value":"Северная Звезда"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Срок годности","value":"1 г."}]}},"fullSpecsGrouped":{"10663102356875382904":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"эндокринная система"},{"name":"Назначение","value":"сахарный диабет"},{"name":"Показания к применению","value":"Сахарный диабет 2 типа: в качестве монотерапии в сочетании с диетотерапией и физическими упражнениями; в составе двухкомпонентной комбинированной терапии с метформином, производными сульфонилмочевины, тиазолидиндионом или с инсулином в случае неэффективности диетотерапии, физических упражнений и монотерапии этими препаратами."},{"name":"Противопоказания","value":"гиперчувствительность к вилдаглиптину и/или любому из вспомогательных веществ, перечисленных в разделе 6.1.;\n\u003Cbr\u003Eнаследственная непереносимость галактозы, дефицит лактазы, \u003Cbr\u003Eглюкозо-галактозная мальабсорбция (см. раздел 4.4.);\n\u003Cbr\u003Eбеременность, грудное вскармливание (в связи с недостатком соответствующих данных) (см. раздел 4.6.);\nсахарный диабет типа 1 (см. раздел 4.4.);\n\u003Cbr\u003Eострый или хронический метаболический ацидоз (включая диабетический кетоацидоз в сочетании с комой или без таковой). \u003Cbr\u003EДиабетический кетоацидоз должен корректироваться инсулинотерапией. Лактоацидоз (в т.ч. и в анамнезе) (см. раздел 4.4.);\n\u003Cbr\u003Eнарушения функции печени, включaя пациентов с повышенной активностью печеночных ферментов (АЛТ или АСТ в 3 и более раз выше верхней границы нормы (3×ВГН);\n\u003Cbr\u003Eхроническая сердечная недостаточность (ХСН) IV функционального класса (ФК) по функциональной классификации Нью-Йоркской кардиологической ассоциации NYHA (ввиду отсутствия данных клинических исследований о применении вилдаглиптина у этой группы пациентов);\n\u003Cbr\u003Eдетский возраст до 18 лет (эффективность и безопасность применения препарата не установлены)."},{"name":"Состав","value":"вилдаглиптин\t50 мг\n\u003Cbr\u003EВспомогательные вещества: целлюлоза микрокристаллическая 102, лактозы моногидрат (лактопресс) (сахар молочный) - 48 мг, карбоксиметилкрахмал натрия, магния стеарат."},{"name":"Действующее вещество","value":"Вилдаглиптин"},{"name":"Способ применения и дозы","value":"Дозу препарата Вилдаглиптин-СЗ следует подбирать индивидуально, в зависимости от эффективности и переносимости.\n\n\u003Cbr\u003EРекомендуемая доза препарата Вилдаглиптин-СЗ 50 мг 1 или 2 раза в сутки.\n\n\u003Cbr\u003EМаксимальная суточная доза препарата составляет 100 мг.\nДозу 50 мг/сут следует принимать 1 раз в сутки утром, дозу 100 мг/сут следует делить на 2 приема — по 50 мг утром и вечером. В случае пропуска приема препарата следует принять пропущенную дозу как можно скорее. При этом следует избегать принятия удвоенной дозы в один день,\n\n\u003Cbr\u003EРекомендуемая доза препарата в монотерапии или в составе комбинированной терапии с метформином, тиазолидиндионом или инсулином (в комбинации с метформином или без метформина) составляет 50 или 100 мг/сут.\n\n\u003Cbr\u003EРекомендуемая доза препарата Вилдаглиптин-СЗ в составе двойной комбинированной терапии с препаратами сульфонилмочевины составляет 50 мг 1 раз в сутки утром. В этой популяции пациентов эффективность вилдаглиптина в дозе l00 мг/сут была сходной с таковой в дозе 50 мг/сут,\n\n\u003Cbr\u003EРекомендуемая доза препарата Вилдаглиптин-СЗ в составе тройной комбинированной терапии (вилдаглиптин + производные сульфонилмочевины + метформин) составляет 100 мг/сут.\n\n\u003Cbr\u003EЕсли цели гликемического контроля не достигнуты на фоне применения максимальной суточной дозы l00 мг, следует рассмотреть возможность добавления к терапии препаратом Вилдаглиптин-СЗ других гипогликемических препаратов, таких как метформин, производные сульфонилмочевины, тиазолидиндион или инсулин."},{"name":"Побочные действия","value":"Со стороны пищеварительной системы: иногда - запоры; редко - нарушения функции печени (включая гепатит) бессимптомного течения; при комбинации с инсулином часто - тошнота, метеоризм, ГЭРБ.\n\n\u003Cbr\u003EСо стороны ЦНС: часто - тремор, головокружение, головная боль.\n\n\u003Cbr\u003EСо стороны обмена веществ: часто - гипогликемия, увеличение массы тела.\n\n\u003Cbr\u003EАллергические реакции: редко - ангионевротический отек (чаще при комбинации с ингибиторами АПФ).\n\n\u003Cbr\u003EПрочие: часто - астения, периферические отеки."},{"name":"Фармакологическое действие","value":"Гипогликемическое средство. Вилдаглиптин - представитель класса стимуляторов островкового аппарата поджелудочной железы, селективно ингибирует фермент дипептидилпептидазу-4 (ДПП-4). Быстрое и полное ингибирование активности ДПП-4 (\u003E 90%) вызывает повышение как базальной, так и стимулированной приемом пищи секреции глюкагоноподобного пептида 1 типа (ГПП-1) и глюкозозависимого инсулинотропного полипептида (ГИП) из кишечника в системный кровоток в течение всего дня.\nУвеличивая уровни ГПП-1 и ГИП, вилдаглиптин вызывает повышение чувствительности β-клеток поджелудочной железы к глюкозе, что приводит к улучшению глюкозозависимой секреции инсулина. При применении вилдаглиптина в дозе 50-100 мг/сут у больных с сахарным диабетом 2 типа отмечается улучшение функции β-клеток поджелудочной железы. Степень улучшения функции β-клеток зависит от степени их исходного повреждения; так у лиц, не страдающих сахарным диабетом (с нормальным уровнем глюкозы в плазме крови) вилдаглиптин не стимулирует секрецию инсулина и не снижает уровень глюкозы.\nПовышая уровни эндогенного ГПП-1, вилдаглиптин увеличивает чувствительность α-клеток к глюкозе, что приводит к улучшению глюкозозависимой регуляции секреции глюкагона. Снижение уровня избыточного глюкагона во время еды, в свою очередь, вызывает уменьшение инсулинорезистентности.\nУвеличение соотношения инсулин/глюкагон на фоне гипергликемии, обусловленное повышением уровней ГПП-1 и ГИП, вызывает уменьшение продукции глюкозы печенью как в прандиальный период, так и после приема пищи, что приводит к снижению уровня глюкозы в плазме крови.\nКроме того, на фоне применения вилдаглиптина отмечается снижение уровня липидов в плазме крови, однако этот эффект не связан с его действием на ГПП-1 или ГИП и улучшением функции β-клеток поджелудочной железы.\nИзвестно, что повышение уровня ГПП-1 может приводить к замедлению опорожнения желудка, однако на фоне применения вилдаглиптина подобного эффекта не наблюдается.\nПри применении вилдаглиптина у 5795 больных с сахарным диабетом 2 типа в течение от 12 до 52 недель в качестве монотерапии или в комбинации с метформином, производными сульфонилмочевины, тиазолидиндионом, или инсулином отмечается достоверное длительное снижение концентрации гликированного гемоглобина (HbA1с) и глюкозы крови натощак."},{"name":"Фармакологическая группа","value":"гиполипидемические средства"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Храните препарат при температуре ниже 25 °C.\n"},{"name":"Условия отпуска из аптеки","value":"по рецепту"},{"name":"Передозировка","value":"Симптомы: вилдаглиптин хорошо переносится при применении в дозе до 200 мг/сут. При применении препарата в дозе 400 мг/сут может наблюдаться боль в мышцах, редко — легкие и транзиторные парестезии, лихорадка, отеки и транзиторное повышение активности липазы (выше ВГН в 2 раза). При увеличении дозы вилдаглиптина до 600 мг/сут возможно развитие отеков конечностей, сопровождающихся парестезиями и повышением активности креатинфосфокиназы, С-реактивного белка и миоглобина, активности АСТ. Все симптомы передозировки и изменения лабораторных показателей обратимы после прекращения применения препарата.\n\n\u003Cbr\u003EЛечение: выведение препарата из организма с помощью диализа маловероятно. Однако основной гидролизный метаболит вилдаглиптина (LAY151) может быть удален из организма путем гемодиализа."},{"name":"Применение при беременности и кормлении грудью","value":"Адекватных и строго контролируемых клинических исследований безопасности применения вилдаглиптина при беременности и в период лактации не проводилось, поэтому не следует применять вилдаглиптин при беременности и в период грудного вскармливания.\n\n\u003Cbr\u003EПри нарушениях обмена глюкозы у беременных женщин отмечается повышение риска развития врожденных аномалий, а также частоты неонатальной заболеваемости и смертности.\nНеизвестно, выделяется ли вилдаглиптин с грудным молоком у человека."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Если у Вас во время приема препарата Вилдаглиптин-СЗ отмечается головокружение, Вы должны воздержаться от управления транспортными средствами и работы с механизмами до исчезновения головокружения."},{"name":"Особые указания","value":"Не рекомендуется применять у пациентов с тяжелыми нарушениями функции печени, в т.ч. при повышении активности АЛТ или АСТ \u003E 2.5 раза выше ВГН.\n\n\u003Cbr\u003EНе рекомендуется применять у пациентов с умеренными или тяжелыми нарушениями функции почек (включая терминальную стадию почечной недостаточности и необходимостью проведения гемодиализа), т.к. данные о безопасности применения у данной категории пациентов ограничены.\n\n\u003Cbr\u003EПеред началом лечения, а также регулярно (1 раз в 3 месяца) в ходе первого года лечения, рекомендуется определять биохимические показатели функции печени. В случае выявления повышенной активности аминотрансфераз, этот результат следует подтвердить повторным исследованием, а затем регулярно проводить определение биохимических показателей функции печени до тех пор, пока они не нормализуются. Если превышение активности АСТ или АЛТ в 3 раза и более ВГН подтверждено повторным исследованием, то вилдаглиптин рекомендуется отменить.\n\n\u003Cbr\u003EПри развитии желтухи или других признаков нарушения функции печени терапию вилдаглиптином следует немедленно прекратить. После нормализации показателей функции печени лечение возобновлять нельзя.\n\n\u003Cbr\u003EПри необходимости инсулинотерапии вилдаглиптин применяют только в комбинации с инсулином.\nВилдаглиптин не следует применять для лечения сахарного диабета 1 типа или для лечения диабетического кетоацидоза."},{"name":"Взаимодействие","value":"Вилдаглиптин обладает низким потенциалом лекарственного взаимодействия. Поскольку вилдаглиптин не является субстратом ферментов цитохрома Р450 (СYР), а также не ингибирует и не индуцирует эти ферменты, взаимодействие вилдаглиптина с лекарственными препаратами, которые являются субстратами, ингибиторами или индукторами Р450 (СYР), маловероятно. При одновременном применении вилдаглиптин также не влияет на скорость метаболизма препаратов, являющихся субстратами ферментов: СYР1A2, СYР2С8, СYР2С9, CYP2C19, СYР2D6 и СYР3А4/5.\n\nКлинически значимого взаимодействия вилдаглиптина с препаратами, наиболее часто используемыми при лечении СД типа 2 (глибенкламидом, пиоглитазоном, метформином) или обладающими узким терапевтическим диапазоном (амлодипином, дигоксином, рамиприлом, симвастатином, валсартаном, варфарином), не установлено. Тиазиды, ГКС, препараты гормонов щитовидной железы, симпатомиметики моryт снижать гипогликемическое действие вилдаглиптина, как и других пероральных противодиабетических препаратов. Частота развития ангионевротического отека была выше при одновременном применении вилдаглиптина с ингибиторами АПФ, при этом была сходной с таковой в контрольной группе. В большинстве случаев ангионевротический отек был средней степени тяжести и разрешался самостоятельно в ходе продолжения терапии вилдаглиптином."},{"name":"Источник","value":"\u003Ca href=\"https://www.vidal.ru\" target=\"_blank\"\u003EСправочник лекарственных препаратов Видаль<\u002Fa\u003E"},{"name":"Регистрационный номер","value":"ЛП-№(000907)-(РГ-RU)"},{"name":"Дата государственной регистрации","value":"20.06.2022"},{"name":"Владелец регистрационного удостоверения","value":"Северная Звезда"},{"name":"Изготовитель","value":"Северная Звезда"},{"name":"Фасовщик","value":"Северная Звезда"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Срок годности","value":"1 г."}]}],"transitionId":"tr_3642927798596423046"}}}}
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    Цена 132 ₽
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  • Вилдаглиптин таб., 50 мг, 28 шт.
    –21 %
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    Вилдаглиптин таб., 50 мг, 28 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 660 ₽ вместо 835
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  • Диаглинид таб., 2 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-zv1is7pj3b/toggleWishlist":{"skuId":"228007697","productId":998360031,"offerId":"NvsxqDVYQOYjMv8voNWa4A","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQqriUtLue/c9LEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI34eH3AMQkb7cbBie1KEFIN7ZwQc=","sign":"jD1h6yKRSohC8SlS/SUv4WTYrcI4C3E5j9QLCBHFoOk="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-zv1is7pj3b/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Диаглинид таб., 2 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 164 ₽
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-zv1is7pj3b/addToCartButton":{"offerId":"NvsxqDVYQOYjMv8voNWa4A","skuId":"228007697","pendingCartItem":{"productId":998360031,"offerId":"NvsxqDVYQOYjMv8voNWa4A","showPlaceId":"OTNDnItfwRMjN9MRHuEMMr4US1j1Hqbs8t1GGkR17cK8fHCY_UkEbfXWibgXWTksgejbhpV9n-zx6cmhcg6CEUKMzzMmcna6mAu58jAhZRl7FpZUI5COy41wCR-ep-GUvP2HviFjzcIheFbPwt4THfQkNshaZpOqY6sPrJMutf-Vc7vw_ZH6yViroijiUskzFMCRiiF0gvpFNyi5h-L8og,,","feeShow":"OTNDnItfwRMjN9MRHuEMMr4US1j1Hqbs8t1GGkR17cK8fHCY_UkEbfXWibgXWTksgejbhpV9n-zx6cmhcg6CEUKMzzMmcna6mAu58jAhZRl7FpZUI5COy41wCR-ep-GUvP2HviFjzcIheFbPwt4THfQkNshaZpOqY6sPrJMutf-Vc7vw_ZH6yViroijiUskzFMCRiiF0gvpFNyi5h-L8og,,","skuId":"228007697","shopId":55106433,"price":{"applicablePriceDiscounts":[],"value":"164","currency":"RUR"},"hid":"15756510","name":"Диаглинид таб., 2 мг, 30 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  • Метглиб таб. п/о плен., 2.5 мг+400 мг, 40 шт.
    –18 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-uxskszq7rka/toggleWishlist":{"skuId":"228056186","productId":1778172456,"offerId":"gOoRiEhjfEB2Fthqgp-ihQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQqriUtLue/c9LEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIqITzzwYQ+rjfbBjOwtkHIN7ZwQc=","sign":"uVlGiWE5M7gP/P8OVzQg+r6KD49vXnANLhVb0dX77LM="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-uxskszq7rka/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Метглиб таб. п/о плен., 2.5 мг+400 мг, 40 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 230 ₽ вместо 280
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  • Глидика М таб. п/о плен., 2 мг+500 мг, 30 шт.
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    Глидика М таб. п/о плен., 2 мг+500 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 4 оценки
    Цена 639 ₽
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  • Метглиб таб. п/о плен., 2.5 мг+400 мг, 40 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-becu2lgwtsp/toggleWishlist":{"skuId":"701583025","productId":1778172495,"offerId":"791rSz1xzP7mZR2GrrgwwQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQqriUtLue/c9LEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIz4TzzwYQsZ3FzgIYzsLZByDe2cEH","sign":"Egr5tsqwr+0GRbAm2xf2GI9pk/m6Xhm4ySBiZOfE4i4="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-becu2lgwtsp/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Метглиб таб. п/о плен., 2.5 мг+400 мг, 40 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 363 ₽
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-becu2lgwtsp/addToCartButton":{"offerId":"791rSz1xzP7mZR2GrrgwwQ","skuId":"701583025","pendingCartItem":{"productId":1778172495,"offerId":"791rSz1xzP7mZR2GrrgwwQ","showPlaceId":"OTNDnItfwRMjN9MRHuEMMr4US1j1HqbsgWx5elXAYJ2vglN-_5RfmM5nSsfKXP86zx4WAgpDDf9Bt8CkrbM_LD1MAf4H9tAAXmblSpEYYwvYDIoymnmHK9jeGIiufxcH4q3pczlBd4z1usgM1fMCODxZF6SIClBw3r9o497YoQYwM3lcsHXzm92Xb8smwKuC19ptksZn0rDCplqDy0bORQ,,","feeShow":"OTNDnItfwRMjN9MRHuEMMr4US1j1HqbsgWx5elXAYJ2vglN-_5RfmM5nSsfKXP86zx4WAgpDDf9Bt8CkrbM_LD1MAf4H9tAAXmblSpEYYwvYDIoymnmHK9jeGIiufxcH4q3pczlBd4z1usgM1fMCODxZF6SIClBw3r9o497YoQYwM3lcsHXzm92Xb8smwKuC19ptksZn0rDCplqDy0bORQ,,","skuId":"701583025","shopId":55106433,"price":{"applicablePriceDiscounts":[],"value":"363","currency":"RUR"},"hid":"15756510","name":"Метглиб таб. п/о плен., 2.5 мг+400 мг, 40 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  • Галвус таб., 50 мг, 28 шт.
    –10 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-nswh0du4f5o/toggleWishlist":{"skuId":"101965853759","productId":1778172503,"offerId":"QjYJoPJkTBsN8IWQMrh4jA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQqriUtLue/c9LEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI14TzzwYQv+iN7fsCGJDVoQUg3tnBBw==","sign":"B159alLzDfHraKFH02fWat0Jc4YhKAU6hJP3xCnv00A="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-nswh0du4f5o/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Галвус таб., 50 мг, 28 шт.

    Рейтинг товара: 4.9 из 5
    на основе 43 оценки
    Цена 824 ₽ вместо 915
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  • Амарил М таб. п/о плен., 2 мг+500 мг, 30 шт.
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    Амарил М таб. п/о плен., 2 мг+500 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 1 159 ₽
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  • Агарта таб., 50 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-cxbtjrullvu/toggleWishlist":{"skuId":"102501566797","productId":21633893,"offerId":"b4cmVcsLxzMOUvKvmz2oTg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQqriUtLue/c9LEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYI5baoChDNksfs/QIY/MPZByDe2cEH","sign":"0DwAOxXU2WcD/iKiomO/qQajygCCeV0yQVMPckUx+Jo="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-cxbtjrullvu/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Агарта таб., 50 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 478 ₽
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  • Глибенкламид таб., 1.75 мг, 120 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-v7xnez4r76q/toggleWishlist":{"skuId":"102793807737","productId":71869033,"offerId":"17M-q1Kgof8J2jVI9y10ew","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQqriUtLue/c9LEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYI6cSiIhD5jvT3/gIYhKmyCCDe2cEH","sign":"xbwFdiavrvR4TorXABrP6CcySR/4Y250oMZi13ODNfA="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-v7xnez4r76q/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Глибенкламид таб., 1.75 мг, 120 шт.

    Цена 114 ₽
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  • Кселевия таб. п/о плен., 100 мг, 28 шт.
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    Кселевия таб. п/о плен., 100 мг, 28 шт.

    Рейтинг товара: 5 из 5
    на основе 10 оценок
    Цена 1 297 ₽
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Инструкция

Показания к применению

Сахарный диабет 2 типа: в качестве монотерапии в сочетании с диетотерапией и физическими упражнениями; в составе двухкомпонентной комбинированной терапии с метформином, производными сульфонилмочевины, тиазолидиндионом или с инсулином в случае неэффективности диетотерапии, физических упражнений и монотерапии этими препаратами.

Противопоказания

гиперчувствительность к вилдаглиптину и/или любому из вспомогательных веществ, перечисленных в разделе 6.1.;
наследственная непереносимость галактозы, дефицит лактазы,
глюкозо-галактозная мальабсорбция (см. раздел 4.4.);
беременность, грудное вскармливание (в связи с недостатком соответствующих данных) (см. раздел 4.6.); сахарный диабет типа 1 (см. раздел 4.4.);
острый или хронический метаболический ацидоз (включая диабетический кетоацидоз в сочетании с комой или без таковой).
Диабетический кетоацидоз должен корректироваться инсулинотерапией. Лактоацидоз (в т.ч. и в анамнезе) (см. раздел 4.4.);
нарушения функции печени, включaя пациентов с повышенной активностью печеночных ферментов (АЛТ или АСТ в 3 и более раз выше верхней границы нормы (3×ВГН);
хроническая сердечная недостаточность (ХСН) IV функционального класса (ФК) по функциональной классификации Нью-Йоркской кардиологической ассоциации NYHA (ввиду отсутствия данных клинических исследований о применении вилдаглиптина у этой группы пациентов);
детский возраст до 18 лет (эффективность и безопасность применения препарата не установлены).

Способ применения и дозы

Дозу препарата Вилдаглиптин-СЗ следует подбирать индивидуально, в зависимости от эффективности и переносимости.
Рекомендуемая доза препарата Вилдаглиптин-СЗ 50 мг 1 или 2 раза в сутки.
Максимальная суточная доза препарата составляет 100 мг. Дозу 50 мг/сут следует принимать 1 раз в сутки утром, дозу 100 мг/сут следует делить на 2 приема — по 50 мг утром и вечером. В случае пропуска приема препарата следует принять пропущенную дозу как можно скорее. При этом следует избегать принятия удвоенной дозы в один день,
Рекомендуемая доза препарата в монотерапии или в составе комбинированной терапии с метформином, тиазолидиндионом или инсулином (в комбинации с метформином или без метформина) составляет 50 или 100 мг/сут.
Рекомендуемая доза препарата Вилдаглиптин-СЗ в составе двойной комбинированной терапии с препаратами сульфонилмочевины составляет 50 мг 1 раз в сутки утром. В этой популяции пациентов эффективность вилдаглиптина в дозе l00 мг/сут была сходной с таковой в дозе 50 мг/сут,
Рекомендуемая доза препарата Вилдаглиптин-СЗ в составе тройной комбинированной терапии (вилдаглиптин + производные сульфонилмочевины + метформин) составляет 100 мг/сут.
Если цели гликемического контроля не достигнуты на фоне применения максимальной суточной дозы l00 мг, следует рассмотреть возможность добавления к терапии препаратом Вилдаглиптин-СЗ других гипогликемических препаратов, таких как метформин, производные сульфонилмочевины, тиазолидиндион или инсулин.
Полная инструкция
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Вилдаглиптин-СЗ
Вилдаглиптин-СЗ, 50 мг, 30 шт.
5.0
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5.0
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