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Описание

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Протопик мазь д/нар.прим., 0.03%, 30 г

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5.0
(18)
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Коротко о товаре

Артикул Маркета
4453168302
Тип препарата
Назначение
Действующее вещество
Возраст
от 2 лет
Инструкция
{"widgets":{"@card/SpecsList":{"/content/page/fancyPage/productSpecsList":{"wrapperProps":{"margins":{"top":4,"bottom":4}},"specsLimit":5,"title":"Коротко о товаре","titleSize":"14","type":"minimal","offset":"s","isHealthCategory":true,"forceShowWidget":true,"withFridge":true}}},"meta":{"/content/page/fancyPage/productSpecsList":{"name":"@card/SpecsList"}},"collections":{"minimalSpecs":{"9714541044792089919":{"specItems":[{"name":"Артикул Маркета","value":"4453168302","withCopyValueButton":true},{"name":"тип препарата","value":"рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"назначение","value":"атопический дерматит","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["36476390:36618732"]}}},{"name":"действующее вещество","value":"Такролимус","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["27144131:28708374"]}}},{"name":"возраст","value":"от 2 лет"},{"name":"форма выпуска","value":"мазь"},{"name":"страна-производитель","value":"Япония"}]}},"compactSpecs":{"9714541044792089919":{"specItems":[{"name":"Артикул Маркета","value":"4453168302","withCopyValueButton":true},{"name":"Тип препарата","value":"Рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"Назначение","value":"Атопический дерматит","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["36476390:36618732"]}}},{"name":"Действующее вещество","value":"Такролимус","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["27144131:28708374"]}}},{"name":"Возраст","value":"От 2 лет"}]}},"fullSpecs":{"9714541044792089919":{"specItems":[{"name":"Тип препарата","value":"лекарственный препарат","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["34324371:35649313"]}}},{"name":"Рецептурный препарат","value":"да","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["27272850:1,0"]}}},{"name":"Органы и системы","value":"кожа","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["34045610:34516012"]}}},{"name":"Назначение","value":"атопический дерматит","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["36476390:36618732"]}}},{"name":"Показания к применению","value":"Мазь Протопик применяется в дозировке 0,03% и 0,1% у взрослых и только 0,03% у детей от 2 до 16 лет для лечения атопического дерматита (средней степени тяжести и тяжелых форм)."},{"name":"Противопоказания","value":"Гиперчувствительность к такролимусу, к вспомогательным веществам, к макролидам.\u003Cbr\u003EБеременность и грудное вскармливание.\u003Cbr\u003EНе следует применять Протопик у пациентов с серьезными нарушениями эпидермального барьера, в частности, синдромом Нетертона, ламеллярным ихтиозом, кожными проявлениями реакции \"трансплантат против хозяина\", а также при генерализованной эритродермии в связи с риском увеличения системной абсорбции такролимуса.\u003Cbr\u003EПрименение мази Протопик в дозировке 0,1% противопоказано у детей и подростков младше 16 лет, в дозировке 0,03% - у детей младше 2 лет."},{"name":"Состав","value":"В 100 г мази (0.03%, 0.1%), содержится 0,03/0,1 г такролимуса (в виде такролимуса моногидрата);\u003Cbr /\u003Eвспомогательные вещества: парафин белый мягкий 77,47/77,40 т, парафин жидкий 11,00/11,00 г, пропиленкарбонат 5,00/5,00, воск пчелиный белый 3,50/3,50 г, парафин твердый 3,00/3,00 г."},{"name":"Действующее вещество","value":"Такролимус","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["27144131:28708374"]}}},{"name":"Способ применения и дозы","value":"Взрослым и детям старше 2 лет мазь Протопик наносят тонким слоем на пораженные участки кожи. Препарат можно применять на любых участках тела, включая лицо и шею, в области кожных складок. Не следует наносить препарат .на слизистые “оболочки и под окклюзионные повязки.\u003Cbr\u003EПрименение v детей (2 года и старше) и подростков до 16 лет\u003Cbr\u003EЛечение необходимо начинать с нанесения 0,03% мази Протопик два раза в сутки. Продолжительность лечения по данной схеме не должна превышать трех недель. В дальнейшем частота применения уменьшается до одного раза в сутки, лечение продолжается до полного очищения очагов поражения.\u003Cbr\u003EПрименение v взрослых и подростков 16 лет и старше\u003Cbr\u003EЛечение необходимо начинать с применения 0,1% мази Протопик два раза в сутки и продолжать до полного очищения очагов поражения. По мере улучшения можно уменьшать частоту нанесения 0,1% мази или переходить на использование 0,03% мази Протопик. В случае повторного возникновения симптомов заболевания следует возобновить лечение 0,1% мазью Протопик дважды в день. Если позволяет клиническая картина, следует предпринять попытку снизить частоту применения препарата, либо использовать меньшую дозировку - 0,03% мазь Протопик.\u003Cbr\u003EПрименение v людей пожилого возраста (65 лет и старше)\u003Cbr\u003EОсобенности применения у людей пожилого возраста отсутствуют.\u003Cbr\u003EОбычно улучшение наблюдается в течение одной недели с момента начала терапии. Если признаки улучшения на фоне терапии отсутствуют в течение двух недель, следует рассмотреть вопрос о смене терапевтической тактики.\u003Cbr\u003EЛечение обострений\u003Cbr\u003EМазь Протопик может использоваться кратковременно или длительно в виде периодически повторяющихся курсов терапии.\u003Cbr\u003EЛечение пораженных участков кожи проводится до полного исчезновения клинических проявлений атопического дерматита. Как правило, улучшение наблюдается в течение первой недели лечения. Если признаки улучшения не наблюдаются в течение двух недель с момента начала использования мази, необходимо рассмотреть другие варианты дальнейшего лечения.\u003Cbr\u003EЛечение следует возобновить при появлении первых признаков обострения атопического дерматита.\u003Cbr\u003EДля предупреждения обострений и увеличения длительности ремиссии у пациентов с частыми (более 4 раз в год) обострениями заболевания в анамнезе рекомендуется поддерживающая терапия мазью Протопик. Целесообразность назначения поддерживающей терапии определяется эффективностью предшествующего лечения по стандартной схеме (2 раза в день) на протяжении не более 6 недель.\u003Cbr\u003EПри поддерживающей терапии мазь Протопик следует наносить 2 раза в неделю (например, в понедельник и четверг) на участки кожи, обычно поражаемые при обострениях.\u003Cbr\u003EПромежуток времени между нанесением препарата должен составлять не менее 2-3 дней. У взрослых и подростков 16 лет и старше используется 0,1% мазь Протопик, v детей (2 года и старше) - 0.03% мазь Протопик. При проявлении признаков обострения следует перейти к обычному режиму терапии мазью Протопик (см.раздел \"Лечение обострений\").\u003Cbr\u003EЧерез 12 месяцев поддерживающей терапии необходимо оценить клиническую динамику и решить вопрос о целесообразности продолжения профилактического использования мази Протопик. У детей для оценки клинической динамики следует временно отменить препарат и затем рассмотреть вопрос о необходимости продолжения поддерживающей терапии."},{"name":"Побочные действия","value":"Наиболее частыми нежелательными реакциями являются симптомы раздражения кожи (ощущение жжения и зуда, покраснение, боль, парестезии и сыпь) в месте нанесения. Как правило, они выражены умеренно или незначительно и проходят в течение первой недели после начала лечения.\u003Cbr\u003EЧасто встречается непереносимость алкоголя (покраснение лица или симптомы раздражения кожи после употребления спиртных напитков).\u003Cbr\u003EУ пациентов, применяющих мазь Протопик, отмечается повышенный риск развития фолликулита, акне и герпетической инфекции.\u003Cbr\u003EПо частоте встречаемости нежелательные реакции делятся на очень частые (\u003E 1/10), частые (\u003E 1/100, \u003C 1/10) и редкие (\u003E1/1,000, \u003C 1/100). В рамках каждой группы нежелательные реакции представлены в порядке убывания значимости.\u003Cbr\u003EОбщие расстройства и местные реакиии\u003Cbr\u003EОчень частые: жжение и зуд в месте применения.\u003Cbr\u003EЧастые: ощущение тепла, покраснение, боль, раздражение, сыпь в месте применения\u003Cbr\u003EС неизвестной частотой: отек в месте применения\u003Cbr\u003EИнфекиии\u003Cbr\u003EЧастые: Местные кожные инфекции вне зависимости от этиологии. В частности (но не ограничиваясь перечисленными), это герпетическая экзема Калоши, фолликулит, инфекция, вызванная вирусом Herpes simplex, другие инфекции, вызванные вирусами семейства Herpesviridae).\u003Cbr\u003EКожа и подкожная клетчатка\u003Cbr\u003EЧастые: фолликулит, зуд.\u003Cbr\u003EНечастые: акне.\u003Cbr\u003EНервная система\u003Cbr\u003EЧастые: парестезии, гиперестезия.\u003Cbr\u003EМетаболизм\u003Cbr\u003EЧастые: непереносимость алкоголя (гиперемия лица или симптомы раздражения кожи после употребления спиртных напитков).\u003Cbr\u003EЗа весь период наблюдения препарата были зарегистрированы единичные случаи розацеа, малигнизации (кожные и другие виды лимфом, рак кожи)."},{"name":"Фармакологическое действие","value":"Такролимус относится к группе ингибиторов кальциневрина. Он связывается со специфическим цитоплазматическим белком иммунофилином (FKBP12), который является цитозольным рецептором для кальциневрина (FK506). В результате этого формируется комплекс, включающий такролимус, FKBP12, кальций, кальмодулин и кальциневрин, что приводит к ингибированию фосфатазной активности кальциневрина. Это делает невозможным дефосфорилирование и транслокацию ядерного фактора активированных Т-клеток (NFAT), необходимого для инициации транскрипции генов, кодирующих продукцию ключевых для Т-клеточного иммунного ответа цитокинов (ИЛ- 2 и интерферон-гамма). Кроме того, такролимус ингибирует транскрипцию генов, кодирующих продукцию таких цитокинов, как ИЛ-3, ИЛ-4, ИЛ-5, гранулоцитарно- макрофагальный колониестимулирующий фактор (ГМКСФ) и фактор некроза опухоли (ФНО-а), которые принимают участие в начальных этапах активации Т-лимфоцитов. Помимо этого, под влиянием такролимуса происходит ингибирование высвобождения медиаторов воспаления из тучных клеток, базофилов и эозинофилов, а также снижение экспрессии FceRI (высокоаффинный поверхностный рецептор для иммуноглобулина Е) на клетках Лангерганса, что ведет к снижению их активности и презентирования антигена Т-лимфоцитам.\u003Cbr\u003EМазь такролимуса не влияет на синтез коллагена и, таким образом, не вызывает атрофию кожи."},{"name":"Фармакологическая группа","value":"противовоспалительное средство для местного применения"},{"name":"Форма выпуска","value":"мазь"},{"name":"Способ применения/введения","value":"наружный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["35947170:36763741"]}}},{"name":"Минимальный возраст применения","value":"от 2 лет"},{"name":"Условия хранения","value":"Хранить при температуре не выше 25°С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"При местном применении случаев передозировки не отмечалось.\u003Cbr\u003EПри попадании внутрь необходимо предпринять общепринятые меры, которые включают контроль жизненно важных функций организма и наблюдение за общим состоянием.\u003Cbr\u003EСтимуляция рвоты или промывание желудка не рекомендуются."},{"name":"Применение при беременности и кормлении грудью","value":"Противопоказан."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Исследования по влиянию мази на способность управлять автомобилем и на быстроту реакции при работе со сложной техникой, требующей повышенного внимания, не проводились. Мазь Протопик применяется наружно и нет оснований полагать, что она может оказывать влияние на способность управлять автомобилем и работать с механизмами."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EПротопик в значительной степени метаболизируется в печени, и, хотя его концентрация в крови при наружном применении очень низкая, у больных с декомпенсированной печеночной недостаточностью мазь используют с осторожностью.\u003Cbr\u003EНеобходимо соблюдать осторожность при использовании мази Протопик у больных с обширным поражением кожи, длительными курсами, особенно у детей.\u003Cbr\u003E"},{"name":"Взаимодействие","value":"Такролимус не метаболизируется в коже, что исключает риск лекарственных взаимодействий в коже, которые могут повлиять на его метаболизм.\u003Cbr\u003EТак как системная абсорбция такролимуса при использовании в форме мази минимальна, взаимодействие с ингибиторами изофермента CYP3A4 (в том числе эритромицин, итраконазол, кетоконазол, дилтиазем) при одновременном применении с мазью Протопик\" маловероятно, однако не может быть полностью исключено у пациентов с обширными участками поражения и/или эритродермией.\u003Cbr\u003EВлияние мази Протопик на эффективность вакцинации не изучалось. Однако, из-за потенциального риска снижения эффективности, вакцинацию необходимо провести до начала применения мази или спустя 14 дней после последнего использования мази Протопик. В случае применения живой аттенуированной вакцины, этот период должен быть увеличен до 28 дней, в противном случае следует рассмотреть возможность использования альтернативных вакцин.\u003Cbr\u003EПрименение у детей Было проведено исследование по изучению взаимодействия с конъюгированной вакциной против Neisseria menigitidis серотипа С, в котором приняли участие дети в возрасте от 2 до 11 лет. Результаты этого исследования свидетельствуют, что одновременное применение такролимуса не оказывало влияния на первичный ответ на вакцинацию, формирование иммунной памяти, а также гуморальный и клеточный иммунный ответ.\u003Cbr\u003EВозможность совместного применения мази Протопик с другими наружными препаратами, системными глюкокортикостероидами и иммунодепрессантами не изучалась."},{"name":"Регистрационный номер","value":"ЛCP-001885/10"},{"name":"Дата государственной регистрации","value":"11.11.2016"},{"name":"Владелец регистрационного удостоверения","value":"LEO Pharma A/S","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["34324371:35649313","7893318:18263130"]}}},{"name":"Фасовщик","value":"Astellas"},{"name":"Страна бренда","value":"Дания"},{"name":"Страна-производитель","value":"Япония"},{"name":"Название препарата","value":"Протопик","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["17796364:17860584"]}}},{"name":"Срок годности","value":"876 дн."}]}},"fullSpecsGrouped":{"9714541044792089919":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"кожа"},{"name":"Назначение","value":"атопический дерматит"},{"name":"Показания к применению","value":"Мазь Протопик применяется в дозировке 0,03% и 0,1% у взрослых и только 0,03% у детей от 2 до 16 лет для лечения атопического дерматита (средней степени тяжести и тяжелых форм)."},{"name":"Противопоказания","value":"Гиперчувствительность к такролимусу, к вспомогательным веществам, к макролидам.\u003Cbr\u003EБеременность и грудное вскармливание.\u003Cbr\u003EНе следует применять Протопик у пациентов с серьезными нарушениями эпидермального барьера, в частности, синдромом Нетертона, ламеллярным ихтиозом, кожными проявлениями реакции \"трансплантат против хозяина\", а также при генерализованной эритродермии в связи с риском увеличения системной абсорбции такролимуса.\u003Cbr\u003EПрименение мази Протопик в дозировке 0,1% противопоказано у детей и подростков младше 16 лет, в дозировке 0,03% - у детей младше 2 лет."},{"name":"Состав","value":"В 100 г мази (0.03%, 0.1%), содержится 0,03/0,1 г такролимуса (в виде такролимуса моногидрата);\u003Cbr /\u003Eвспомогательные вещества: парафин белый мягкий 77,47/77,40 т, парафин жидкий 11,00/11,00 г, пропиленкарбонат 5,00/5,00, воск пчелиный белый 3,50/3,50 г, парафин твердый 3,00/3,00 г."},{"name":"Действующее вещество","value":"Такролимус"},{"name":"Способ применения и дозы","value":"Взрослым и детям старше 2 лет мазь Протопик наносят тонким слоем на пораженные участки кожи. Препарат можно применять на любых участках тела, включая лицо и шею, в области кожных складок. Не следует наносить препарат .на слизистые “оболочки и под окклюзионные повязки.\u003Cbr\u003EПрименение v детей (2 года и старше) и подростков до 16 лет\u003Cbr\u003EЛечение необходимо начинать с нанесения 0,03% мази Протопик два раза в сутки. Продолжительность лечения по данной схеме не должна превышать трех недель. В дальнейшем частота применения уменьшается до одного раза в сутки, лечение продолжается до полного очищения очагов поражения.\u003Cbr\u003EПрименение v взрослых и подростков 16 лет и старше\u003Cbr\u003EЛечение необходимо начинать с применения 0,1% мази Протопик два раза в сутки и продолжать до полного очищения очагов поражения. По мере улучшения можно уменьшать частоту нанесения 0,1% мази или переходить на использование 0,03% мази Протопик. В случае повторного возникновения симптомов заболевания следует возобновить лечение 0,1% мазью Протопик дважды в день. Если позволяет клиническая картина, следует предпринять попытку снизить частоту применения препарата, либо использовать меньшую дозировку - 0,03% мазь Протопик.\u003Cbr\u003EПрименение v людей пожилого возраста (65 лет и старше)\u003Cbr\u003EОсобенности применения у людей пожилого возраста отсутствуют.\u003Cbr\u003EОбычно улучшение наблюдается в течение одной недели с момента начала терапии. Если признаки улучшения на фоне терапии отсутствуют в течение двух недель, следует рассмотреть вопрос о смене терапевтической тактики.\u003Cbr\u003EЛечение обострений\u003Cbr\u003EМазь Протопик может использоваться кратковременно или длительно в виде периодически повторяющихся курсов терапии.\u003Cbr\u003EЛечение пораженных участков кожи проводится до полного исчезновения клинических проявлений атопического дерматита. Как правило, улучшение наблюдается в течение первой недели лечения. Если признаки улучшения не наблюдаются в течение двух недель с момента начала использования мази, необходимо рассмотреть другие варианты дальнейшего лечения.\u003Cbr\u003EЛечение следует возобновить при появлении первых признаков обострения атопического дерматита.\u003Cbr\u003EДля предупреждения обострений и увеличения длительности ремиссии у пациентов с частыми (более 4 раз в год) обострениями заболевания в анамнезе рекомендуется поддерживающая терапия мазью Протопик. Целесообразность назначения поддерживающей терапии определяется эффективностью предшествующего лечения по стандартной схеме (2 раза в день) на протяжении не более 6 недель.\u003Cbr\u003EПри поддерживающей терапии мазь Протопик следует наносить 2 раза в неделю (например, в понедельник и четверг) на участки кожи, обычно поражаемые при обострениях.\u003Cbr\u003EПромежуток времени между нанесением препарата должен составлять не менее 2-3 дней. У взрослых и подростков 16 лет и старше используется 0,1% мазь Протопик, v детей (2 года и старше) - 0.03% мазь Протопик. При проявлении признаков обострения следует перейти к обычному режиму терапии мазью Протопик (см.раздел \"Лечение обострений\").\u003Cbr\u003EЧерез 12 месяцев поддерживающей терапии необходимо оценить клиническую динамику и решить вопрос о целесообразности продолжения профилактического использования мази Протопик. У детей для оценки клинической динамики следует временно отменить препарат и затем рассмотреть вопрос о необходимости продолжения поддерживающей терапии."},{"name":"Побочные действия","value":"Наиболее частыми нежелательными реакциями являются симптомы раздражения кожи (ощущение жжения и зуда, покраснение, боль, парестезии и сыпь) в месте нанесения. Как правило, они выражены умеренно или незначительно и проходят в течение первой недели после начала лечения.\u003Cbr\u003EЧасто встречается непереносимость алкоголя (покраснение лица или симптомы раздражения кожи после употребления спиртных напитков).\u003Cbr\u003EУ пациентов, применяющих мазь Протопик, отмечается повышенный риск развития фолликулита, акне и герпетической инфекции.\u003Cbr\u003EПо частоте встречаемости нежелательные реакции делятся на очень частые (\u003E 1/10), частые (\u003E 1/100, \u003C 1/10) и редкие (\u003E1/1,000, \u003C 1/100). В рамках каждой группы нежелательные реакции представлены в порядке убывания значимости.\u003Cbr\u003EОбщие расстройства и местные реакиии\u003Cbr\u003EОчень частые: жжение и зуд в месте применения.\u003Cbr\u003EЧастые: ощущение тепла, покраснение, боль, раздражение, сыпь в месте применения\u003Cbr\u003EС неизвестной частотой: отек в месте применения\u003Cbr\u003EИнфекиии\u003Cbr\u003EЧастые: Местные кожные инфекции вне зависимости от этиологии. В частности (но не ограничиваясь перечисленными), это герпетическая экзема Калоши, фолликулит, инфекция, вызванная вирусом Herpes simplex, другие инфекции, вызванные вирусами семейства Herpesviridae).\u003Cbr\u003EКожа и подкожная клетчатка\u003Cbr\u003EЧастые: фолликулит, зуд.\u003Cbr\u003EНечастые: акне.\u003Cbr\u003EНервная система\u003Cbr\u003EЧастые: парестезии, гиперестезия.\u003Cbr\u003EМетаболизм\u003Cbr\u003EЧастые: непереносимость алкоголя (гиперемия лица или симптомы раздражения кожи после употребления спиртных напитков).\u003Cbr\u003EЗа весь период наблюдения препарата были зарегистрированы единичные случаи розацеа, малигнизации (кожные и другие виды лимфом, рак кожи)."},{"name":"Фармакологическое действие","value":"Такролимус относится к группе ингибиторов кальциневрина. Он связывается со специфическим цитоплазматическим белком иммунофилином (FKBP12), который является цитозольным рецептором для кальциневрина (FK506). В результате этого формируется комплекс, включающий такролимус, FKBP12, кальций, кальмодулин и кальциневрин, что приводит к ингибированию фосфатазной активности кальциневрина. Это делает невозможным дефосфорилирование и транслокацию ядерного фактора активированных Т-клеток (NFAT), необходимого для инициации транскрипции генов, кодирующих продукцию ключевых для Т-клеточного иммунного ответа цитокинов (ИЛ- 2 и интерферон-гамма). Кроме того, такролимус ингибирует транскрипцию генов, кодирующих продукцию таких цитокинов, как ИЛ-3, ИЛ-4, ИЛ-5, гранулоцитарно- макрофагальный колониестимулирующий фактор (ГМКСФ) и фактор некроза опухоли (ФНО-а), которые принимают участие в начальных этапах активации Т-лимфоцитов. Помимо этого, под влиянием такролимуса происходит ингибирование высвобождения медиаторов воспаления из тучных клеток, базофилов и эозинофилов, а также снижение экспрессии FceRI (высокоаффинный поверхностный рецептор для иммуноглобулина Е) на клетках Лангерганса, что ведет к снижению их активности и презентирования антигена Т-лимфоцитам.\u003Cbr\u003EМазь такролимуса не влияет на синтез коллагена и, таким образом, не вызывает атрофию кожи."},{"name":"Фармакологическая группа","value":"противовоспалительное средство для местного применения"},{"name":"Форма выпуска","value":"мазь"},{"name":"Способ применения/введения","value":"наружный"},{"name":"Минимальный возраст применения","value":"от 2 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Хранить при температуре не выше 25°С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"При местном применении случаев передозировки не отмечалось.\u003Cbr\u003EПри попадании внутрь необходимо предпринять общепринятые меры, которые включают контроль жизненно важных функций организма и наблюдение за общим состоянием.\u003Cbr\u003EСтимуляция рвоты или промывание желудка не рекомендуются."},{"name":"Применение при беременности и кормлении грудью","value":"Противопоказан."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Исследования по влиянию мази на способность управлять автомобилем и на быстроту реакции при работе со сложной техникой, требующей повышенного внимания, не проводились. Мазь Протопик применяется наружно и нет оснований полагать, что она может оказывать влияние на способность управлять автомобилем и работать с механизмами."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EПротопик в значительной степени метаболизируется в печени, и, хотя его концентрация в крови при наружном применении очень низкая, у больных с декомпенсированной печеночной недостаточностью мазь используют с осторожностью.\u003Cbr\u003EНеобходимо соблюдать осторожность при использовании мази Протопик у больных с обширным поражением кожи, длительными курсами, особенно у детей.\u003Cbr\u003E"},{"name":"Взаимодействие","value":"Такролимус не метаболизируется в коже, что исключает риск лекарственных взаимодействий в коже, которые могут повлиять на его метаболизм.\u003Cbr\u003EТак как системная абсорбция такролимуса при использовании в форме мази минимальна, взаимодействие с ингибиторами изофермента CYP3A4 (в том числе эритромицин, итраконазол, кетоконазол, дилтиазем) при одновременном применении с мазью Протопик\" маловероятно, однако не может быть полностью исключено у пациентов с обширными участками поражения и/или эритродермией.\u003Cbr\u003EВлияние мази Протопик на эффективность вакцинации не изучалось. Однако, из-за потенциального риска снижения эффективности, вакцинацию необходимо провести до начала применения мази или спустя 14 дней после последнего использования мази Протопик. В случае применения живой аттенуированной вакцины, этот период должен быть увеличен до 28 дней, в противном случае следует рассмотреть возможность использования альтернативных вакцин.\u003Cbr\u003EПрименение у детей Было проведено исследование по изучению взаимодействия с конъюгированной вакциной против Neisseria menigitidis серотипа С, в котором приняли участие дети в возрасте от 2 до 11 лет. Результаты этого исследования свидетельствуют, что одновременное применение такролимуса не оказывало влияния на первичный ответ на вакцинацию, формирование иммунной памяти, а также гуморальный и клеточный иммунный ответ.\u003Cbr\u003EВозможность совместного применения мази Протопик с другими наружными препаратами, системными глюкокортикостероидами и иммунодепрессантами не изучалась."},{"name":"Регистрационный номер","value":"ЛCP-001885/10"},{"name":"Дата государственной регистрации","value":"11.11.2016"},{"name":"Владелец регистрационного удостоверения","value":"LEO Pharma A/S"},{"name":"Фасовщик","value":"Astellas"},{"name":"Страна бренда","value":"Дания"},{"name":"Страна-производитель","value":"Япония"},{"name":"Название препарата","value":"Протопик"},{"name":"Срок годности","value":"876 дн."}]}],"transitionId":"tr_10721524880593746119"}}}}
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    Цена 561 ₽
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  • Элидел крем д/нар. прим., 1%, 15 г
    –20 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ky9sqskteag/toggleWishlist":{"skuId":"228136587","productId":1430987439,"offerId":"UC1MV0pTnECCQt78WiB5jw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQ1ciyifee45KJARIxCi9Db21wZXRpdGl2ZUFuYWxvZ3NfTWFya2V0TW9kZWxDYXJkX0Zyb250U25pcHBldDIVCK/FrKoFEIut5GwYqbn5ByDl2cEH","sign":"llmhiSzVO4lB6JCGBNiBEmpqI1vaWRi0zdZbMorSHto="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ky9sqskteag/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Элидел крем д/нар. прим., 1%, 15 г

    Рейтинг товара: 4.9 из 5
    на основе 34 оценки
    Цена 1 002 ₽ вместо 1 253
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  • Дайвобет мазь, 15 г
    –1 %
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    Дайвобет мазь, 15 г

    Рейтинг товара: 4.8 из 5
    на основе 57 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 509 ₽ вместо 1 524
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  • Дайвонекс мазь, 0.005%, 30 мл, 30 г
    –2 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-4q9u9mvlv96/toggleWishlist":{"skuId":"101581407735","productId":228043991,"offerId":"aS8w3rsadxJGJ4uRyqzKUw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQ1ciyifee45KJARIxCi9Db21wZXRpdGl2ZUFuYWxvZ3NfTWFya2V0TW9kZWxDYXJkX0Zyb250U25pcHBldDIWCNfZ3mwQ94vltfoCGNrY2ggg5dnBBw==","sign":"ILjCLsORNcBWuoF3/IHmfrQApxB7YZHvHxwulZasPcw="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-4q9u9mvlv96/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Дайвонекс мазь, 0.005%, 30 мл, 30 г

    Рейтинг товара: 4.7 из 5
    на основе 21 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 521 ₽ вместо 1 553
    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  • Лостерин крем, 75 мл, 102 г, 1 шт., 1 уп.
    –19 %
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    Лостерин крем, 75 мл, 102 г, 1 шт., 1 уп.

    Рейтинг товара: 4.6 из 5
    на основе 223 оценки
    Цена 1 222 ₽ вместо 1 515
    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  • Солантра крем д/нар. прим. туба, 1%, 30 мл, 30 г, 1 шт.
    –13 %
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    Солантра крем д/нар. прим. туба, 1%, 30 мл, 30 г, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 44 оценки
    Цена 2 546 ₽ вместо 2 928
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  • Триакорт мазь д/нар. прим. туба, 0.1%, 10 г, 1 шт.
    –1 %
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    Триакорт мазь д/нар. прим. туба, 0.1%, 10 г, 1 шт.

    Рейтинг товара: 4.8 из 5
    на основе 18 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 232 ₽ вместо 234
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  • Бепантен мазь д/нар. прим., 5%, 100 мл, 100 г, 1 шт.
    –2 %
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    Бепантен мазь д/нар. прим., 5%, 100 мл, 100 г, 1 шт.

    Рейтинг товара: 4.9 из 5
    на основе 69 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 222 ₽ вместо 1 246
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  • Азелик гель д/нар. прим., 15%, 30 мл, 30 г
    –1 %
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    Азелик гель д/нар. прим., 15%, 30 мл, 30 г

    Рейтинг товара: 4.8 из 5
    на основе 87 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 994 ₽ вместо 1 004
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  • Ксамиол гель д/нар. прим., 15 г
    –1 %
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    Ксамиол гель д/нар. прим., 15 г

    Рейтинг товара: 4.7 из 5
    на основе 54 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 509 ₽ вместо 1 524
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  • Розамет крем, 1%, 25 мл, 25 г
    –1 %
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    Розамет крем, 1%, 25 мл, 25 г

    Рейтинг товара: 4.5 из 5
    на основе 10 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 359 ₽ вместо 363
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  • Фуцидин мазь, 2 %, 15 г
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    Фуцидин мазь, 2 %, 15 г

    Рейтинг товара: 4.7 из 5
    на основе 10 оценок
    Цена 706 ₽
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Инструкция

Показания к применению

Мазь Протопик применяется в дозировке 0,03% и 0,1% у взрослых и только 0,03% у детей от 2 до 16 лет для лечения атопического дерматита (средней степени тяжести и тяжелых форм).

Противопоказания

Гиперчувствительность к такролимусу, к вспомогательным веществам, к макролидам.
Беременность и грудное вскармливание.
Не следует применять Протопик у пациентов с серьезными нарушениями эпидермального барьера, в частности, синдромом Нетертона, ламеллярным ихтиозом, кожными проявлениями реакции "трансплантат против хозяина", а также при генерализованной эритродермии в связи с риском увеличения системной абсорбции такролимуса.
Применение мази Протопик в дозировке 0,1% противопоказано у детей и подростков младше 16 лет, в дозировке 0,03% - у детей младше 2 лет.

Способ применения и дозы

Взрослым и детям старше 2 лет мазь Протопик наносят тонким слоем на пораженные участки кожи. Препарат можно применять на любых участках тела, включая лицо и шею, в области кожных складок. Не следует наносить препарат .на слизистые “оболочки и под окклюзионные повязки.
Применение v детей (2 года и старше) и подростков до 16 лет
Лечение необходимо начинать с нанесения 0,03% мази Протопик два раза в сутки. Продолжительность лечения по данной схеме не должна превышать трех недель. В дальнейшем частота применения уменьшается до одного раза в сутки, лечение продолжается до полного очищения очагов поражения.
Применение v взрослых и подростков 16 лет и старше
Лечение необходимо начинать с применения 0,1% мази Протопик два раза в сутки и продолжать до полного очищения очагов поражения. По мере улучшения можно уменьшать частоту нанесения 0,1% мази или переходить на использование 0,03% мази Протопик. В случае повторного возникновения симптомов заболевания следует возобновить лечение 0,1% мазью Протопик дважды в день. Если позволяет клиническая картина, следует предпринять попытку снизить частоту применения препарата, либо использовать меньшую дозировку - 0,03% мазь Протопик.
Применение v людей пожилого возраста (65 лет и старше)
Особенности применения у людей пожилого возраста отсутствуют.
Обычно улучшение наблюдается в течение одной недели с момента начала терапии. Если признаки улучшения на фоне терапии отсутствуют в течение двух недель, следует рассмотреть вопрос о смене терапевтической тактики.
Лечение обострений
Мазь Протопик может использоваться кратковременно или длительно в виде периодически повторяющихся курсов терапии.
Лечение пораженных участков кожи проводится до полного исчезновения клинических проявлений атопического дерматита. Как правило, улучшение наблюдается в течение первой недели лечения. Если признаки улучшения не наблюдаются в течение двух недель с момента начала использования мази, необходимо рассмотреть другие варианты дальнейшего лечения.
Лечение следует возобновить при появлении первых признаков обострения атопического дерматита.
Для предупреждения обострений и увеличения длительности ремиссии у пациентов с частыми (более 4 раз в год) обострениями заболевания в анамнезе рекомендуется поддерживающая терапия мазью Протопик. Целесообразность назначения поддерживающей терапии определяется эффективностью предшествующего лечения по стандартной схеме (2 раза в день) на протяжении не более 6 недель.
При поддерживающей терапии мазь Протопик следует наносить 2 раза в неделю (например, в понедельник и четверг) на участки кожи, обычно поражаемые при обострениях.
Промежуток времени между нанесением препарата должен составлять не менее 2-3 дней. У взрослых и подростков 16 лет и старше используется 0,1% мазь Протопик, v детей (2 года и старше) - 0.03% мазь Протопик. При проявлении признаков обострения следует перейти к обычному режиму терапии мазью Протопик (см.раздел "Лечение обострений").
Через 12 месяцев поддерживающей терапии необходимо оценить клиническую динамику и решить вопрос о целесообразности продолжения профилактического использования мази Протопик. У детей для оценки клинической динамики следует временно отменить препарат и затем рассмотреть вопрос о необходимости продолжения поддерживающей терапии.
Полная инструкция
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Протопик мазь д/нар.прим.
Протопик мазь д/нар.прим., 0.03%, 30 г
5.0
(18)
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4 вопроса
Инструкция

1 096 ₽

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5.0
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У продавца:18 оценок·3 отзыва
У всех продавцов:170 оценок·34 отзыва
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user avatar
3 месяца назад • Эльмира Алиакберова • Куплен на Маркете
Достоинства: В нашем городе в аптеках этой мази нет. Здорово, что есть возможность заказать её через яндекс.
Комментарий: Мазь назначают собаке с диагнозом : плазмома. На оптиммун к сожалению у нас привыкание, теперь для лечения нам нужен протопик пожизненно...Аналоги не подойдут. Так, что здорово, что можно купить у Вас с доставкой в аптеку.
user avatar
5 месяцев назад • Ola-la • Куплен на Маркете
Достоинства: не увидели пользы, вернее, даже было негативное ощущение от применения
Недостатки: очень дорогой
Комментарий: Была мазь выписана дерматологом в связи с шелушением и растрескиванием кожи на ладонях. Причина и диагноз не определены. Намазал вечером, наутро кожа стала грубее, похожа на рыбью чешую, и цвет чешуек - белый. В общем, мужу не помогло.
user avatar
5 месяцев назад • Наталья А. • Куплен на Маркете
Комментарий: Принимаем по рекомендации врача.
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