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Описание

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Цианокобаламин р-р д/ин. амп., 0.5 мг/мл, 10 шт.

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Коротко о товаре

Артикул Маркета
4453139557
Дозировка
Объем
1 мл
Количество штук в упаковке
10 шт.
Тип препарата
Инструкция
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В организме (преимущественно в печени) превращается в метилкобаламин и 5-дезоксиаденозилкобаламин. Метилкобаламин участвует в реакции превращения гомоцистеина в метионин и S-аденозилметионин - ключевые реакции метаболизма пиримидиновых и пуриновых оснований (а, следовательно, ДНК и РНК). При недостаточности витамина в данной реакции его может замещать метилтетрагидрофолиевая кислота, при этом нарушаются фолиевопотребные реакции метаболизма. 5-дезоксиаденозилкобаламин служит кофактором при изомеризации L-метилмалонил-КоА в сукцинил-КоА - важной реакции метаболизма углеводов и липидов.\u003Cbr\u003EДефицит витамина-В 12- приводит к нарушению .пролиферации, быстроделящихся клеток кроветворной ткани и эпителия, а также к нарушению образования миелиновой оболочки нейронов."},{"name":"Состав","value":"Активное вещество: цианокобаламин - 0,2 мг или 0,5 мг. Вспомогательное вещество: натрия хлорид - 9 мг; вода для инъекций - до 1 мл."},{"name":"Взаимодействие","value":"Фармацевтически несовместим с аскорбиновой кислотой, солями тяжелых металлов (инактивация цианокобаламина), тиамином, пиридоксином, рибофлавином (т.к. содержащийся в молекуле цианкобаламина ион кобальта разрушает другие витамины). Нельзя сочетать с препаратами, повышающими свертываемость крови. Риск развития аллергических реакций повышается при совместном применении с тиамином.\u003Cbr\u003EХлорамфеникол снижает гемопоэтический ответ цианокобаламина. Не следует сочетать с препаратами, повышающими свертываемость крови."},{"name":"Показания к применению","value":"Состояния, сопровождающиеся дефицитом витамина В12: В12-дефицитная анемия; в составе комплексной терапии анемий (в т.ч. железодефицитной, постгеморрагической, апластической, анемий, вызванных токсическими веществами и/или лекарственными средствами). В комплексной терапии:\u003Cbr\u003EВ неврологии: невралгия (в т.ч. невралгия тройничного нерва), полинейропатия (в том числе алкогольная).\u003Cbr\u003EС профилактической целью - при назначении бигуанидов, ПАСК, аскорбиновой кислоты в высоких дозах, патологии желудка и кишечника с нарушением всасывания витамина В12 (резекция части желудка, тонкой кишки, болезнь Крона, синдром мальабсорбции, спру), лучевая болезнь."},{"name":"Противопоказания","value":"Повышенная чувствительность к компонентам препарата, тромбоэмболия, эритремия, эритроцитоз, беременность (имеются отдельные указания о возможном тератогенном действии витаминов группы В в высоких дозах), период лактации.\u003Cbr\u003EС осторожностью:\u003Cbr\u003EСтенокардия, доброкачественные и злокачественные новообразования, сопровождающиеся мегалобластной анемией и дефицитом витамина В12, склонность к образованию тромбов."},{"name":"Способ применения и дозы","value":"Препарат применяется подкожно, внутримышечно, внутривенно.\u003Cbr\u003EПодкожно, при В12-дефицитной анемии - по 100-200 мкг/сут через день; при В12 -дефицитной анемии с присоединением нарушений функции нервной системы - по 400-500 мкг/сут в первую неделю - ежедневно, затем с интервалами между введениями до 5-7 дней (одновременно назначают фолиевую кислоту); в период ремиссии поддерживающая доза - 100 мкг/сут 2 раза в месяц, при наличии неврологических симптомов - по 200-400 мкг 2-4 раза в мес.\u003Cbr\u003EПри острой постгеморрагической и железодефицитной анемии - 30-100 мкг 2-3 раза в неделю; при апластической анемии, анемиях, вызванных токсическими веществами и/или лекарственными средствами - по 100 мкг до наступления клинико-гематологического улучшения. При нарушениях со стороны нервной системы - по 200-400 мкг 2-4 раза в месяц.\u003Cbr\u003EВ неврологии: невралгия (в т.ч. невралгия тройничного нерва), полинейропатия (в том числе алкогольная) - по 200-500 мкг через день в течение 2 нед.\u003Cbr\u003EС профилактической целью - по 60-100 мкг ежедневно в течение 20-30 дней.\u003Cbr\u003E\u003Cbr\u003EДля устранения дефицита витамина В12 вводят внутримышечно (в/м) или внутривенно (в/в) по 1 мг ежедневно в \u003Cbr\u003E\u003Cbr\u003EДетям раннего возраста при алиментарной анемии и недоношенным детям подкожно 30 мкг в день ежедневно в течение 15 дней."},{"name":"Применение при беременности","value":"Противопоказано."},{"name":"Побочные действия","value":"Аллергические реакции, психическое возбуждение, кардиалгия, тахикардия, диарея, головная боль, головокружение, гиперкоагуляция, нарушение пуринового обмена."},{"name":"Передозировка","value":"Данные отсутствуют."},{"name":"Условия хранения","value":"В защищенном от света месте при температуре от 5 до 25° С. Хранить в недоступном для детей месте."},{"name":"Особые указания","value":"Дефицит цианокобаламина должен быть подтвержден диагностически до назначения препарата, поскольку может маскировать недостаток фолиевой кислоты. В период лечения необходимо контролировать показатели периферической крови: на 5-8 день лечения определяется содержание ретикулоцитов, концентрация железа. Количество эритроцитов, гемоглобин и цветовой показатель необходимо контролировать в течение 1 мес. 1-2 раза в неделю, а далее - 2-4 раза в месяц. Ремиссия достигается при повышении количества эритроцитов до 4-4,5 млн/мкл, при достижении нормальных размеров эритроцитов, исчезновении анизо- и пойкилоцитоза, нормализации содержания ретикулоцитов после ретикулоцитарного криза. После достижения гематологической ремиссии, контроль периферической крови проводится не реже 1 раза в 4-6 мес.\u003Cbr\u003EСоблюдать осторожность у лиц склонных к тромбообразованию, со стенокардией (в меньших дозах до 100 мкг на введение). Принимать длительное время при пернициозной анемии, предстоящих операциях на желудочно-кишечном тракте."},{"name":"Страна бренда","value":"Россия"},{"name":"Страна производства","value":"Россия"},{"name":"Владелец регистрационного удостоверения","value":"Дальхимфарм"},{"name":"Изготовитель","value":"Дальхимфарм"},{"name":"Фасовщик","value":"Дальхимфарм"}]}},"fullSpecsGrouped":{"13006989610528633755":{"groups":[{"name":"Регистрационные данные","items":[{"name":"Дозировка","value":"0.5 мг/мл"},{"name":"Объем","value":"1 мл"},{"name":"Количество штук в упаковке","value":"10 шт."}]},{"name":"Тип препарата","items":[{"name":"Особенности","value":"для детей"},{"name":"Рецептурный препарат","value":"да"},{"name":"Способ применения/введения","value":"парентеральный"},{"name":"Форма выпуска","value":"раствор для инъекций"}]},{"name":"Применение и информация","items":[{"name":"Действующее вещество","value":"Цианокобаламин"},{"name":"Фармакологическая группа","value":"витамины группы В"},{"name":"Фармакологическое действие","value":"Витамин В12. В организме (преимущественно в печени) превращается в метилкобаламин и 5-дезоксиаденозилкобаламин. Метилкобаламин участвует в реакции превращения гомоцистеина в метионин и S-аденозилметионин - ключевые реакции метаболизма пиримидиновых и пуриновых оснований (а, следовательно, ДНК и РНК). При недостаточности витамина в данной реакции его может замещать метилтетрагидрофолиевая кислота, при этом нарушаются фолиевопотребные реакции метаболизма. 5-дезоксиаденозилкобаламин служит кофактором при изомеризации L-метилмалонил-КоА в сукцинил-КоА - важной реакции метаболизма углеводов и липидов.\u003Cbr\u003EДефицит витамина-В 12- приводит к нарушению .пролиферации, быстроделящихся клеток кроветворной ткани и эпителия, а также к нарушению образования миелиновой оболочки нейронов."},{"name":"Состав","value":"Активное вещество: цианокобаламин - 0,2 мг или 0,5 мг. Вспомогательное вещество: натрия хлорид - 9 мг; вода для инъекций - до 1 мл."},{"name":"Взаимодействие","value":"Фармацевтически несовместим с аскорбиновой кислотой, солями тяжелых металлов (инактивация цианокобаламина), тиамином, пиридоксином, рибофлавином (т.к. содержащийся в молекуле цианкобаламина ион кобальта разрушает другие витамины). Нельзя сочетать с препаратами, повышающими свертываемость крови. Риск развития аллергических реакций повышается при совместном применении с тиамином.\u003Cbr\u003EХлорамфеникол снижает гемопоэтический ответ цианокобаламина. Не следует сочетать с препаратами, повышающими свертываемость крови."},{"name":"Показания к применению","value":"Состояния, сопровождающиеся дефицитом витамина В12: В12-дефицитная анемия; в составе комплексной терапии анемий (в т.ч. железодефицитной, постгеморрагической, апластической, анемий, вызванных токсическими веществами и/или лекарственными средствами). В комплексной терапии:\u003Cbr\u003EВ неврологии: невралгия (в т.ч. невралгия тройничного нерва), полинейропатия (в том числе алкогольная).\u003Cbr\u003EС профилактической целью - при назначении бигуанидов, ПАСК, аскорбиновой кислоты в высоких дозах, патологии желудка и кишечника с нарушением всасывания витамина В12 (резекция части желудка, тонкой кишки, болезнь Крона, синдром мальабсорбции, спру), лучевая болезнь."},{"name":"Противопоказания","value":"Повышенная чувствительность к компонентам препарата, тромбоэмболия, эритремия, эритроцитоз, беременность (имеются отдельные указания о возможном тератогенном действии витаминов группы В в высоких дозах), период лактации.\u003Cbr\u003EС осторожностью:\u003Cbr\u003EСтенокардия, доброкачественные и злокачественные новообразования, сопровождающиеся мегалобластной анемией и дефицитом витамина В12, склонность к образованию тромбов."},{"name":"Способ применения и дозы","value":"Препарат применяется подкожно, внутримышечно, внутривенно.\u003Cbr\u003EПодкожно, при В12-дефицитной анемии - по 100-200 мкг/сут через день; при В12 -дефицитной анемии с присоединением нарушений функции нервной системы - по 400-500 мкг/сут в первую неделю - ежедневно, затем с интервалами между введениями до 5-7 дней (одновременно назначают фолиевую кислоту); в период ремиссии поддерживающая доза - 100 мкг/сут 2 раза в месяц, при наличии неврологических симптомов - по 200-400 мкг 2-4 раза в мес.\u003Cbr\u003EПри острой постгеморрагической и железодефицитной анемии - 30-100 мкг 2-3 раза в неделю; при апластической анемии, анемиях, вызванных токсическими веществами и/или лекарственными средствами - по 100 мкг до наступления клинико-гематологического улучшения. При нарушениях со стороны нервной системы - по 200-400 мкг 2-4 раза в месяц.\u003Cbr\u003EВ неврологии: невралгия (в т.ч. невралгия тройничного нерва), полинейропатия (в том числе алкогольная) - по 200-500 мкг через день в течение 2 нед.\u003Cbr\u003EС профилактической целью - по 60-100 мкг ежедневно в течение 20-30 дней.\u003Cbr\u003E\u003Cbr\u003EДля устранения дефицита витамина В12 вводят внутримышечно (в/м) или внутривенно (в/в) по 1 мг ежедневно в \u003Cbr\u003E\u003Cbr\u003EДетям раннего возраста при алиментарной анемии и недоношенным детям подкожно 30 мкг в день ежедневно в течение 15 дней."},{"name":"Применение при беременности","value":"Противопоказано."},{"name":"Побочные действия","value":"Аллергические реакции, психическое возбуждение, кардиалгия, тахикардия, диарея, головная боль, головокружение, гиперкоагуляция, нарушение пуринового обмена."},{"name":"Передозировка","value":"Данные отсутствуют."},{"name":"Условия хранения","value":"В защищенном от света месте при температуре от 5 до 25° С. Хранить в недоступном для детей месте."},{"name":"Особые указания","value":"Дефицит цианокобаламина должен быть подтвержден диагностически до назначения препарата, поскольку может маскировать недостаток фолиевой кислоты. В период лечения необходимо контролировать показатели периферической крови: на 5-8 день лечения определяется содержание ретикулоцитов, концентрация железа. Количество эритроцитов, гемоглобин и цветовой показатель необходимо контролировать в течение 1 мес. 1-2 раза в неделю, а далее - 2-4 раза в месяц. Ремиссия достигается при повышении количества эритроцитов до 4-4,5 млн/мкл, при достижении нормальных размеров эритроцитов, исчезновении анизо- и пойкилоцитоза, нормализации содержания ретикулоцитов после ретикулоцитарного криза. После достижения гематологической ремиссии, контроль периферической крови проводится не реже 1 раза в 4-6 мес.\u003Cbr\u003EСоблюдать осторожность у лиц склонных к тромбообразованию, со стенокардией (в меньших дозах до 100 мкг на введение). Принимать длительное время при пернициозной анемии, предстоящих операциях на желудочно-кишечном тракте."},{"name":"Страна бренда","value":"Россия"},{"name":"Страна производства","value":"Россия"},{"name":"Владелец регистрационного удостоверения","value":"Дальхимфарм"},{"name":"Изготовитель","value":"Дальхимфарм"},{"name":"Фасовщик","value":"Дальхимфарм"}]}],"transitionId":"tr_6410046950743230092"}}}}
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5 ₽/шт

51 ₽/уп

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    Цена 48 ₽
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  • Рибофлавин мононуклеотид р-р д/ин., 10 мг/мл, 10 шт.
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    Рибофлавин мононуклеотид р-р д/ин., 10 мг/мл, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 7 оценок
    Цена 210 ₽
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  • Комбилипен р-р д/ин., 5 шт.
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    Комбилипен р-р д/ин., 5 шт.

    Рейтинг товара: 5 из 5
    на основе 63 оценки
    Цена 337 ₽
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  • Тиамин хлорид (витамин в1) р-р д/ин., 5%, 10 шт.
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    Тиамин хлорид (витамин в1) р-р д/ин., 5%, 10 шт.

    Рейтинг товара: 4.8 из 5
    на основе 25 оценок
    Цена 49 ₽
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  • Пиридоксин раствор для инъекций 50 мг/мл 1 мл 10 шт
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    Пиридоксин раствор для инъекций 50 мг/мл 1 мл 10 шт

    Рейтинг товара: 4.9 из 5
    на основе 9 оценок
    Цена 65 ₽
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  • Никотиновая кислота р-р д/ин. амп., 10 мг/мл, 10 шт.
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    Никотиновая кислота р-р д/ин. амп., 10 мг/мл, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 21 оценка
    Цена 233 ₽
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  • Пиридоксин (вит в6) р-р д/ин., 50 мг/мл, 10 шт.
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    Пиридоксин (вит в6) р-р д/ин., 50 мг/мл, 10 шт.

    Рейтинг товара: 4.5 из 5
    на основе 12 оценок
    Цена 39 ₽
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  • Мильгамма р-р для в/м введ., 5 шт.
    –16 %
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    Мильгамма р-р для в/м введ., 5 шт.

    Рейтинг товара: 4.9 из 5
    на основе 90 оценок
    Цена 619 ₽ вместо 737
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  • Аскорбиновая кислота р-р для в/в введ. и в/м введ. амп, 50 мг/мл, 10 шт.
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    Аскорбиновая кислота р-р для в/в введ. и в/м введ. амп, 50 мг/мл, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 20 оценок
    Цена 45 ₽
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Инструкция

Показания к применению

Состояния, сопровождающиеся дефицитом витамина В12: В12-дефицитная анемия; в составе комплексной терапии анемий (в т.ч. железодефицитной, постгеморрагической, апластической, анемий, вызванных токсическими веществами и/или лекарственными средствами). В комплексной терапии:
В неврологии: невралгия (в т.ч. невралгия тройничного нерва), полинейропатия (в том числе алкогольная).
С профилактической целью - при назначении бигуанидов, ПАСК, аскорбиновой кислоты в высоких дозах, патологии желудка и кишечника с нарушением всасывания витамина В12 (резекция части желудка, тонкой кишки, болезнь Крона, синдром мальабсорбции, спру), лучевая болезнь.

Противопоказания

Повышенная чувствительность к компонентам препарата, тромбоэмболия, эритремия, эритроцитоз, беременность (имеются отдельные указания о возможном тератогенном действии витаминов группы В в высоких дозах), период лактации.
С осторожностью:
Стенокардия, доброкачественные и злокачественные новообразования, сопровождающиеся мегалобластной анемией и дефицитом витамина В12, склонность к образованию тромбов.

Способ применения и дозы

Препарат применяется подкожно, внутримышечно, внутривенно.
Подкожно, при В12-дефицитной анемии - по 100-200 мкг/сут через день; при В12 -дефицитной анемии с присоединением нарушений функции нервной системы - по 400-500 мкг/сут в первую неделю - ежедневно, затем с интервалами между введениями до 5-7 дней (одновременно назначают фолиевую кислоту); в период ремиссии поддерживающая доза - 100 мкг/сут 2 раза в месяц, при наличии неврологических симптомов - по 200-400 мкг 2-4 раза в мес.
При острой постгеморрагической и железодефицитной анемии - 30-100 мкг 2-3 раза в неделю; при апластической анемии, анемиях, вызванных токсическими веществами и/или лекарственными средствами - по 100 мкг до наступления клинико-гематологического улучшения. При нарушениях со стороны нервной системы - по 200-400 мкг 2-4 раза в месяц.
В неврологии: невралгия (в т.ч. невралгия тройничного нерва), полинейропатия (в том числе алкогольная) - по 200-500 мкг через день в течение 2 нед.
С профилактической целью - по 60-100 мкг ежедневно в течение 20-30 дней.

Для устранения дефицита витамина В12 вводят внутримышечно (в/м) или внутривенно (в/в) по 1 мг ежедневно в

Детям раннего возраста при алиментарной анемии и недоношенным детям подкожно 30 мкг в день ежедневно в течение 15 дней.
Полная инструкция
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Цианокобаламин р-р д/ин. амп.
Цианокобаламин р-р д/ин. амп., 0.5 мг/мл, 10 шт.
5.0
(18)
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6 вопросов
Инструкция

51 ₽/уп

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5.0
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У продавца:18 оценок·1 отзыв
У всех продавцов:145 оценок·33 отзыва
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2 месяца назад • Александр Орленко • Куплен на Маркете
Достоинства: хорошие витамины
Недостатки: нет
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