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Описание

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Лидокаин р-р д/ин., 20 мг/мл, 2 мл, 10 шт.

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5.0
(4)
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Коротко о товаре

Артикул Маркета
3123128654
Тип препарата
Назначение
Действующее вещество
Страна-производитель
Россия
Инструкция
{"widgets":{"@card/SpecsList":{"/content/page/fancyPage/productSpecsList":{"wrapperProps":{"margins":{"top":4,"bottom":4}},"specsLimit":5,"title":"Коротко о товаре","titleSize":"14","type":"minimal","offset":"s","isHealthCategory":true,"forceShowWidget":true,"withFridge":true}}},"meta":{"/content/page/fancyPage/productSpecsList":{"name":"@card/SpecsList"}},"collections":{"minimalSpecs":{"16496732644458600233":{"specItems":[{"name":"Артикул Маркета","value":"3123128654","withCopyValueButton":true},{"name":"тип препарата","value":"рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"anesteziia-rastvoriteli-i-kontrastnye-veshchestva","categoryId":"15758037","navnodeId":"72693","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"назначение","value":"местная анестезия, проводниковая анестезия, хирургическая анестезия","transition":{"type":"list","params":{"categorySlug":"anesteziia-rastvoriteli-i-kontrastnye-veshchestva","categoryId":"15758037","navnodeId":"72693","glfilters":["36476390:36618980,36618701,36617586"]}}},{"name":"действующее вещество","value":"Лидокаин","transition":{"type":"list","params":{"categorySlug":"anesteziia-rastvoriteli-i-kontrastnye-veshchestva","categoryId":"15758037","navnodeId":"72693","glfilters":["27144131:28708280"]}}},{"name":"страна-производитель","value":"Россия"}]}},"compactSpecs":{"16496732644458600233":{"specItems":[{"name":"Артикул Маркета","value":"3123128654","withCopyValueButton":true},{"name":"Тип препарата","value":"Рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"anesteziia-rastvoriteli-i-kontrastnye-veshchestva","categoryId":"15758037","navnodeId":"72693","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"Действующее вещество","value":"Лидокаин","transition":{"type":"list","params":{"categorySlug":"anesteziia-rastvoriteli-i-kontrastnye-veshchestva","categoryId":"15758037","navnodeId":"72693","glfilters":["27144131:28708280"]}}},{"name":"Страна-производитель","value":"Россия"}]}},"fullSpecs":{"16496732644458600233":{"specItems":[{"name":"Тип препарата","value":"лекарственный препарат","transition":{"type":"catalog","params":{"categorySlug":"anesteziia-rastvoriteli-i-kontrastnye-veshchestva","categoryId":"15758037","navnodeId":"72693","glfilters":["34324371:35649313"]}}},{"name":"Рецептурный препарат","value":"да","transition":{"type":"catalog","params":{"categorySlug":"anesteziia-rastvoriteli-i-kontrastnye-veshchestva","categoryId":"15758037","navnodeId":"72693","glfilters":["27272850:1,0"]}}},{"name":"Назначение","value":"местная анестезия, проводниковая анестезия, хирургическая анестезия","transition":{"type":"catalog","params":{"categorySlug":"anesteziia-rastvoriteli-i-kontrastnye-veshchestva","categoryId":"15758037","navnodeId":"72693","glfilters":["36476390:36618980,36618701,36617586"]}}},{"name":"Органы и системы","value":"нервная система"},{"name":"Показания к применению","value":"В кардиологической практике: лечение и профилактика желудочковых аритмий (экстрасистолия, тахикардия, трепетание, фибрилляция), в т.ч. в остром периоде инфаркта миокарда, при имплантации искусственного водителя ритма, при гликозидной интоксикации, наркозе.\u003Cbr\u003EДля анестезии: терминальная, инфильтрационная, проводниковая, спинномозговая (эпидуральная) анестезия в хирургии, акушерстве и гинекологии, урологии, офтальмологии, стоматологии, оториноларингологии; блокада периферических нервов и нервных узлов."},{"name":"Противопоказания","value":"Тяжелые кровотечения, шок, артериальная гипотензия, инфицирование места предполагаемой инъекции, выраженная брадикардия, кардиогенный шок, тяжелые формы хронической сердечной недостаточности, СССУ у пациентов пожилого возраста, AV-блокада II и III степени (за исключением случаев, когда введен зонд для стимуляции желудочков), тяжелые нарушения функции печени.\u003Cbr\u003EДля субарахноидальной анестезии - полная блокада сердца, кровотечения, артериальная гипотензия, шок, инфицирование места проведения люмбальной пункции, септицемия.\u003Cbr\u003EПовышенная чувствительность к лидокаину и другим местным анестетикам амидного типа."},{"name":"Состав","value":"Действующее вещество: лидокаина гидрохлорида моногидрат – 20 мг\u003Cbr\u003EВспомогательные вещества: натрия хлорид – 6 мг, вода д/и – до 1 мл, натрия гидроксида раствор 1М – до pH 5.0-7.0\u003Cbr/\u003E"},{"name":"Действующее вещество","value":"Лидокаин","transition":{"type":"catalog","params":{"categorySlug":"anesteziia-rastvoriteli-i-kontrastnye-veshchestva","categoryId":"15758037","navnodeId":"72693","glfilters":["27144131:28708280"]}}},{"name":"Способ применения и дозы","value":"В качестве антиаритмического средства взрослым при введении нагрузочной дозы в/в - 1-2 мг/кг в течение 3-4 мин; средняя разовая доза 80 мг. Затем сразу переходят на капельную инфузию со скоростью 20-55 мкг/кг/мин. Капельную инфузию можно проводить в течение 24-36 ч. При необходимости на фоне капельной инфузии можно повторить в/в струйное введение лидокаина в дозе 40 мг через 10 мин после первой нагрузочной дозы.\u003Cbr\u003EВ/м вводят по 2-4 мг/кг, при необходимости повторное введение возможно через 60-90 мин.\u003Cbr\u003EДетям при в/в введении нагрузочной дозы - 1 мг/кг, при необходимости возможно повторное введение через 5 мин. Для непрерывной в/в инфузии (обычно после введения нагрузочной дозы) - 20-30 мкг/кг/мин.\u003Cbr\u003EДля применения в хирургической и акушерской практике, стоматологии, ЛОР-практике режим дозирования устанавливают индивидуально, в зависимости от показаний, клинической ситуации и используемой лекарственной формы.\u003Cbr\u003EМаксимальные дозы: взрослым при в/в введении нагрузочная доза - 100 мг, при последующей капельной инфузии - 2 мг/мин; при в/м введении - 300 мг (около 4.5 мг/кг) в течение 1 ч.\u003Cbr\u003EДетям в случае повторного введения нагрузочной дозы с интервалом 5 мин суммарная доза составляет 3 мг/кг; при непрерывной в/в инфузии (обычно после введения нагрузочной дозы) - 50 мкг/кг/мин."},{"name":"Побочные действия","value":"Со стороны ЦНС и периферической нервной системы: головокружение, головная боль, слабость, двигательное беспокойство, нистагм, потеря сознания, сонливость, зрительные и слуховые нарушения, тремор, тризм, судороги (риск их развития повышается на фоне гиперкапнии и ацидоза), синдром \"конского хвоста\" (паралич ног, парестезии), паралич дыхательных мышц, остановка дыхания, блок моторный и чувствительный, респираторный паралич (чаще развивается при субарахноидальной анестезии), онемение языка (при использовании в стоматологии).\u003Cbr\u003EСо стороны сердечно-сосудистой системы: повышение или снижение АД, тахикардия - при введении с вазоконстриктором, периферическая вазодилатация, коллапс, боль в грудной клетке.\u003Cbr\u003EСо стороны пищеварительной системы: тошнота, рвота, непроизвольная дефекация.\u003Cbr\u003EАллергические реакции: кожная сыпь, крапивница (на коже и слизистых оболочках), зуд кожи, ангионевротический отек, анафилактический шок.\u003Cbr\u003EМестные реакции: при спинальной анестезии - боль в спине, при эпидуральной анестезии - случайное попадание в субарахноидальное пространство; при местном применении в урологии - уретрит.\u003Cbr\u003EПрочие: непроизвольное мочеиспускание, метгемоглобинемия, стойкая анестезия, снижение либидо и/или потенции, угнетение дыхания, вплоть до остановки, гипотермия; при анестезии в стоматологии: потеря чувствительности и парестезии губ и языка, удлинение анестезии."},{"name":"Фармакологическое действие","value":"Антиаритмическое средство класса IB, местный анестетик, производное ацетанилида. Обладает мембраностабилизирующей активностью. Вызывает блокаду натриевых каналов возбудимых мембран нейронов и мембран кардиомиоцитов.\u003Cbr\u003EУменьшает продолжительность потенциала действия и эффективного рефрактерного периода в волокнах Пуркинье, подавляет их автоматизм. При этом лидокаин подавляет электрическую активность деполяризованных, аритмогенных участков, но минимально влияет на электрическую активность нормальных тканей. При применении в средних терапевтических дозах практически не изменяет сократимость миокарда и не замедляет AV-проводимость. При применении в качестве антиаритмического средства при в/в введении начало действия через 45-90 сек, длительность - 10-20 мин; при в/м введении начало действия через 5-15 мин, длительность - 60-90 мин.\u003Cbr\u003EВызывает все виды местной анестезии: терминальную, инфильтрационную, проводниковую."},{"name":"Фармакологическая группа","value":"местноанестезирующее средство"},{"name":"Форма выпуска","value":"раствор для инъекций"},{"name":"Способ применения/введения","value":"парентеральный","transition":{"type":"catalog","params":{"categorySlug":"anesteziia-rastvoriteli-i-kontrastnye-veshchestva","categoryId":"15758037","navnodeId":"72693","glfilters":["35947170:36763748"]}}},{"name":"Условия хранения","value":"Хранить при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте. Срок годности - 2 года."},{"name":"Передозировка","value":"Симптомы\u003Cbr\u003EТоксичность со стороны центральной нервной системы проявляется симптомами, нарастающими по тяжести. Сначала может развиться парестезия вокруг рта, онемение языка, головокружение, гиперакузия и шум в ушах. Нарушение зрения и мышечный тремор или мышечные подергивания свидетельствуют о более серьезной токсичности и предшествуют генерализованным судорогам. Затем могут наступить потеря сознания и большие судорожные припадки продолжительностью от нескольких секунд до нескольких минут. Судороги приводят к быстрому нарастанию гипоксии и гиперкапнии, обусловленных повышенной мышечной активностью и нарушением дыхания. В тяжелых случаях может развиться апноэ. Ацидоз усиливает токсические эффекты местных анестетиков.\u003Cbr\u003EВ тяжелых случаях возникают нарушения со стороны сердечно-сосудистой системы. При высокой системной концентрации могут развиться артериальная гипотензия, брадикардия, аритмия и остановка сердца, которые могут оказаться летальными.\u003Cbr\u003EРазрешение передозировки происходит вследствие перераспределения местного анестетика из центральной нервной системы и его метаболизма, оно может протекать достаточно быстро (если нс была введена очень большая доза препарата).\u003Cbr\u003EЛечение\u003Cbr\u003EПри возникновении признаков передозировки введение анестетика следует немедленно прекратить.\u003Cbr\u003EСудороги, угнетение ЦНС и кардиотоксичность требуют медицинского вмешательства. Главные цели терапии заключаются в поддержании оксигенации, прекращении судорог, поддержании адекватного кровообращения и купировании ацидоза (в случае его развития). В соответствующих случаях необходимо обеспечить проходимость дыхательных путей и назначить кислород, а также наладить вспомогательную вентиляцию легких (масочную или с помощью мешка Амбу). Поддержание кровообращения осуществляется посредством вливания плазмы или инфузионных растворов. При необходимости длительного поддержания кровообращения, следует рассмотреть возможность введения вазопрессоров, однако они повышают риск возбуждения ЦНС. Контроль судорог можно достичь посредством внутривенного введения диазепама (0,1 мг/кг) или тиопентала натрия (1-3 мг/кг), при этом следует учитывать, что противосудорожные средства могут также угнетать дыхание и кровообращение. Продолжительные судороги могут препятствовать вентиляции легких и оксигенации пациента, в связи с чем следует рассмотреть возможность ранней эндотрахеальной интубации. При остановке сердца приступают к стандартной сердечно- легочной реанимации.\u003Cbr\u003EЭффективность диализа при лечении острой передозировки лидокаином очень низкая."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения необходимо соблюдать осторожность при вождении автотранспорта и занятии другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"C осторожностью следует применять при состояниях, сопровождающихся снижением печеночного кровотока (в т.ч. при хронической сердечной недостаточности, заболеваниях печени), прогрессирующей сердечно-сосудистой недостаточности (обычно вследствие развития блокад сердца и шока), у тяжелых и ослабленных больных, у пациентов пожилого возраста (старше 65 лет); для эпидуральной анестезии - при неврологических заболеваниях, септицемии, невозможности проведения пункции из-за деформации позвоночника; для субарахноидальной анестезии - при боли в спине, инфекции головного мозга, доброкачественных и злокачественных новообразованиях головного мозга, при коагулопатиях различного генеза, мигрени, субарахноидальном кровоизлиянии, артериальной гипертензии, артериальной гипотензии, парестезии, психозе, истерии, у неконтактных больных, невозможности проведения пункции из-за деформации позвоночника.\u003Cbr\u003EСледует с осторожностью вводить растворы лидокаина в ткани с обильной васкуляризацией (например, в область шеи при операциях на щитовидной железе), в таких случаях лидокаин применяют в меньших дозах.\u003Cbr\u003EПри одновременном применении с бета-адреноблокаторами, с циметидином требуется уменьшение дозы лидокаина; с полимиксином В - следует контролировать функцию дыхания.\u003Cbr\u003EВ период лечения ингибиторами МАО не следует применять лидокаин парентерально.\u003Cbr\u003EРастворы для инъекций, в состав которых входят эпинефрин и норэпинефрин, не предназначены для в/в введения.\u003Cbr\u003EЛидокаин нельзя добавлять в переливаемую кровь.\u003Cbr\u003EВлияние на способность к вождению автотранспорта и управлению механизмами\u003Cbr\u003EПосле применения лидокаина не рекомендуется заниматься видами деятельности, требующими высокой концентрации внимания и быстрых психомоторных реакций."},{"name":"Взаимодействие","value":"При одновременном применении с барбитуратами (в т.ч. с фенобарбиталом) возможно повышение метаболизма лидокаина в печени, снижение концентрации в плазме крови и, вследствие этого, уменьшение его терапевтической эффективности.\u003Cbr\u003EПри одновременном применении с бета-адреноблокаторами (в т.ч. с пропранололом, надололом) возможно усиление эффектов лидокаина (в т.ч. токсических), по-видимому, вследствие замедления его метаболизма в печени.\u003Cbr\u003EПри одновременном применении с ингибиторами МАО возможно усиление местноанестезирующего действия лидокаина.\u003Cbr\u003EПри одновременном применении с препаратами, вызывающими блокаду нервно-мышечной передачи (в т.ч. с суксаметония хлоридом) возможно усиление действия препаратов, вызывающих блокаду нервно-мышечной передачи.\u003Cbr\u003EПри одновременном применении со снотворными и седативными средствами возможно усиление угнетающего действия на ЦНС; с аймалином, хинидином - возможно усиление кардиодепрессивного действия; с амиодароном - описаны случаи развития судорог и СССУ.\u003Cbr\u003EПри одновременном применении с гексеналом, тиопенталом натрия (в/в) возможно угнетение дыхания.\u003Cbr\u003EПри одновременном применении с мексилетином повышается токсичность лидокаина; с мидазоламом - умеренное уменьшение концентрации лидокаина в плазме крови; с морфином - усиление анальгезирующего эффекта морфина.\u003Cbr\u003EПри одновременном применении с прениламином развивается риск развития желудочковой аритмии типа \"пируэт\".\u003Cbr\u003EОписаны случаи возбуждения, галлюцинаций при одновременном применении с прокаинамидом.\u003Cbr\u003EПри одновременном применении с пропафеноном возможно увеличение продолжительности и повышение степени тяжести побочных эффектов со стороны ЦНС.\u003Cbr\u003EПолагают, что под влиянием рифампицина возможно уменьшение концентрации лидокаина в плазме крови.\u003Cbr\u003EПри одновременной в/в инфузии лидокаина и фенитоина возможно усиление побочных эффектов центрального генеза; описан случай синоатриальной блокады вследствие аддитивного кардиодепрессивного действия лидокаина и фенитоина.\u003Cbr\u003EУ пациентов, получающих фенитоин в качестве противосудорожного средства, возможно уменьшение концентрации лидокаина в плазме крови, что обусловлено индукцией микросомальных ферментов печени под влиянием фенитоина.\u003Cbr\u003EПри одновременном применении с циметидином умеренно уменьшается клиренс лидокаина и повышается его концентрация в плазме крови, имеется риск усиления побочного действия лидокаина."},{"name":"Регистрационный номер","value":"ЛП-003014"},{"name":"Дата государственной регистрации","value":"03.06.2020"},{"name":"Владелец регистрационного удостоверения","value":"Гротекс","transition":{"type":"catalog","params":{"categorySlug":"anesteziia-rastvoriteli-i-kontrastnye-veshchestva","categoryId":"15758037","navnodeId":"72693","glfilters":["34324371:35649313","7893318:16002823"]}}},{"name":"Изготовитель","value":"Гротекс"},{"name":"Фасовщик","value":"Гротекс"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Лидокаин","transition":{"type":"catalog","params":{"categorySlug":"anesteziia-rastvoriteli-i-kontrastnye-veshchestva","categoryId":"15758037","navnodeId":"72693","glfilters":["17796364:17879631"]}}},{"name":"Срок годности","value":"25 мес."}]}},"fullSpecsGrouped":{"16496732644458600233":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Назначение","value":"местная анестезия, проводниковая анестезия, хирургическая анестезия"},{"name":"Органы и системы","value":"нервная система"},{"name":"Показания к применению","value":"В кардиологической практике: лечение и профилактика желудочковых аритмий (экстрасистолия, тахикардия, трепетание, фибрилляция), в т.ч. в остром периоде инфаркта миокарда, при имплантации искусственного водителя ритма, при гликозидной интоксикации, наркозе.\u003Cbr\u003EДля анестезии: терминальная, инфильтрационная, проводниковая, спинномозговая (эпидуральная) анестезия в хирургии, акушерстве и гинекологии, урологии, офтальмологии, стоматологии, оториноларингологии; блокада периферических нервов и нервных узлов."},{"name":"Противопоказания","value":"Тяжелые кровотечения, шок, артериальная гипотензия, инфицирование места предполагаемой инъекции, выраженная брадикардия, кардиогенный шок, тяжелые формы хронической сердечной недостаточности, СССУ у пациентов пожилого возраста, AV-блокада II и III степени (за исключением случаев, когда введен зонд для стимуляции желудочков), тяжелые нарушения функции печени.\u003Cbr\u003EДля субарахноидальной анестезии - полная блокада сердца, кровотечения, артериальная гипотензия, шок, инфицирование места проведения люмбальной пункции, септицемия.\u003Cbr\u003EПовышенная чувствительность к лидокаину и другим местным анестетикам амидного типа."},{"name":"Состав","value":"Действующее вещество: лидокаина гидрохлорида моногидрат – 20 мг\u003Cbr\u003EВспомогательные вещества: натрия хлорид – 6 мг, вода д/и – до 1 мл, натрия гидроксида раствор 1М – до pH 5.0-7.0\u003Cbr/\u003E"},{"name":"Действующее вещество","value":"Лидокаин"},{"name":"Способ применения и дозы","value":"В качестве антиаритмического средства взрослым при введении нагрузочной дозы в/в - 1-2 мг/кг в течение 3-4 мин; средняя разовая доза 80 мг. Затем сразу переходят на капельную инфузию со скоростью 20-55 мкг/кг/мин. Капельную инфузию можно проводить в течение 24-36 ч. При необходимости на фоне капельной инфузии можно повторить в/в струйное введение лидокаина в дозе 40 мг через 10 мин после первой нагрузочной дозы.\u003Cbr\u003EВ/м вводят по 2-4 мг/кг, при необходимости повторное введение возможно через 60-90 мин.\u003Cbr\u003EДетям при в/в введении нагрузочной дозы - 1 мг/кг, при необходимости возможно повторное введение через 5 мин. Для непрерывной в/в инфузии (обычно после введения нагрузочной дозы) - 20-30 мкг/кг/мин.\u003Cbr\u003EДля применения в хирургической и акушерской практике, стоматологии, ЛОР-практике режим дозирования устанавливают индивидуально, в зависимости от показаний, клинической ситуации и используемой лекарственной формы.\u003Cbr\u003EМаксимальные дозы: взрослым при в/в введении нагрузочная доза - 100 мг, при последующей капельной инфузии - 2 мг/мин; при в/м введении - 300 мг (около 4.5 мг/кг) в течение 1 ч.\u003Cbr\u003EДетям в случае повторного введения нагрузочной дозы с интервалом 5 мин суммарная доза составляет 3 мг/кг; при непрерывной в/в инфузии (обычно после введения нагрузочной дозы) - 50 мкг/кг/мин."},{"name":"Побочные действия","value":"Со стороны ЦНС и периферической нервной системы: головокружение, головная боль, слабость, двигательное беспокойство, нистагм, потеря сознания, сонливость, зрительные и слуховые нарушения, тремор, тризм, судороги (риск их развития повышается на фоне гиперкапнии и ацидоза), синдром \"конского хвоста\" (паралич ног, парестезии), паралич дыхательных мышц, остановка дыхания, блок моторный и чувствительный, респираторный паралич (чаще развивается при субарахноидальной анестезии), онемение языка (при использовании в стоматологии).\u003Cbr\u003EСо стороны сердечно-сосудистой системы: повышение или снижение АД, тахикардия - при введении с вазоконстриктором, периферическая вазодилатация, коллапс, боль в грудной клетке.\u003Cbr\u003EСо стороны пищеварительной системы: тошнота, рвота, непроизвольная дефекация.\u003Cbr\u003EАллергические реакции: кожная сыпь, крапивница (на коже и слизистых оболочках), зуд кожи, ангионевротический отек, анафилактический шок.\u003Cbr\u003EМестные реакции: при спинальной анестезии - боль в спине, при эпидуральной анестезии - случайное попадание в субарахноидальное пространство; при местном применении в урологии - уретрит.\u003Cbr\u003EПрочие: непроизвольное мочеиспускание, метгемоглобинемия, стойкая анестезия, снижение либидо и/или потенции, угнетение дыхания, вплоть до остановки, гипотермия; при анестезии в стоматологии: потеря чувствительности и парестезии губ и языка, удлинение анестезии."},{"name":"Фармакологическое действие","value":"Антиаритмическое средство класса IB, местный анестетик, производное ацетанилида. Обладает мембраностабилизирующей активностью. Вызывает блокаду натриевых каналов возбудимых мембран нейронов и мембран кардиомиоцитов.\u003Cbr\u003EУменьшает продолжительность потенциала действия и эффективного рефрактерного периода в волокнах Пуркинье, подавляет их автоматизм. При этом лидокаин подавляет электрическую активность деполяризованных, аритмогенных участков, но минимально влияет на электрическую активность нормальных тканей. При применении в средних терапевтических дозах практически не изменяет сократимость миокарда и не замедляет AV-проводимость. При применении в качестве антиаритмического средства при в/в введении начало действия через 45-90 сек, длительность - 10-20 мин; при в/м введении начало действия через 5-15 мин, длительность - 60-90 мин.\u003Cbr\u003EВызывает все виды местной анестезии: терминальную, инфильтрационную, проводниковую."},{"name":"Фармакологическая группа","value":"местноанестезирующее средство"},{"name":"Форма выпуска","value":"раствор для инъекций"},{"name":"Способ применения/введения","value":"парентеральный"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Хранить при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте. Срок годности - 2 года."},{"name":"Передозировка","value":"Симптомы\u003Cbr\u003EТоксичность со стороны центральной нервной системы проявляется симптомами, нарастающими по тяжести. Сначала может развиться парестезия вокруг рта, онемение языка, головокружение, гиперакузия и шум в ушах. Нарушение зрения и мышечный тремор или мышечные подергивания свидетельствуют о более серьезной токсичности и предшествуют генерализованным судорогам. Затем могут наступить потеря сознания и большие судорожные припадки продолжительностью от нескольких секунд до нескольких минут. Судороги приводят к быстрому нарастанию гипоксии и гиперкапнии, обусловленных повышенной мышечной активностью и нарушением дыхания. В тяжелых случаях может развиться апноэ. Ацидоз усиливает токсические эффекты местных анестетиков.\u003Cbr\u003EВ тяжелых случаях возникают нарушения со стороны сердечно-сосудистой системы. При высокой системной концентрации могут развиться артериальная гипотензия, брадикардия, аритмия и остановка сердца, которые могут оказаться летальными.\u003Cbr\u003EРазрешение передозировки происходит вследствие перераспределения местного анестетика из центральной нервной системы и его метаболизма, оно может протекать достаточно быстро (если нс была введена очень большая доза препарата).\u003Cbr\u003EЛечение\u003Cbr\u003EПри возникновении признаков передозировки введение анестетика следует немедленно прекратить.\u003Cbr\u003EСудороги, угнетение ЦНС и кардиотоксичность требуют медицинского вмешательства. Главные цели терапии заключаются в поддержании оксигенации, прекращении судорог, поддержании адекватного кровообращения и купировании ацидоза (в случае его развития). В соответствующих случаях необходимо обеспечить проходимость дыхательных путей и назначить кислород, а также наладить вспомогательную вентиляцию легких (масочную или с помощью мешка Амбу). Поддержание кровообращения осуществляется посредством вливания плазмы или инфузионных растворов. При необходимости длительного поддержания кровообращения, следует рассмотреть возможность введения вазопрессоров, однако они повышают риск возбуждения ЦНС. Контроль судорог можно достичь посредством внутривенного введения диазепама (0,1 мг/кг) или тиопентала натрия (1-3 мг/кг), при этом следует учитывать, что противосудорожные средства могут также угнетать дыхание и кровообращение. Продолжительные судороги могут препятствовать вентиляции легких и оксигенации пациента, в связи с чем следует рассмотреть возможность ранней эндотрахеальной интубации. При остановке сердца приступают к стандартной сердечно- легочной реанимации.\u003Cbr\u003EЭффективность диализа при лечении острой передозировки лидокаином очень низкая."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения необходимо соблюдать осторожность при вождении автотранспорта и занятии другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"C осторожностью следует применять при состояниях, сопровождающихся снижением печеночного кровотока (в т.ч. при хронической сердечной недостаточности, заболеваниях печени), прогрессирующей сердечно-сосудистой недостаточности (обычно вследствие развития блокад сердца и шока), у тяжелых и ослабленных больных, у пациентов пожилого возраста (старше 65 лет); для эпидуральной анестезии - при неврологических заболеваниях, септицемии, невозможности проведения пункции из-за деформации позвоночника; для субарахноидальной анестезии - при боли в спине, инфекции головного мозга, доброкачественных и злокачественных новообразованиях головного мозга, при коагулопатиях различного генеза, мигрени, субарахноидальном кровоизлиянии, артериальной гипертензии, артериальной гипотензии, парестезии, психозе, истерии, у неконтактных больных, невозможности проведения пункции из-за деформации позвоночника.\u003Cbr\u003EСледует с осторожностью вводить растворы лидокаина в ткани с обильной васкуляризацией (например, в область шеи при операциях на щитовидной железе), в таких случаях лидокаин применяют в меньших дозах.\u003Cbr\u003EПри одновременном применении с бета-адреноблокаторами, с циметидином требуется уменьшение дозы лидокаина; с полимиксином В - следует контролировать функцию дыхания.\u003Cbr\u003EВ период лечения ингибиторами МАО не следует применять лидокаин парентерально.\u003Cbr\u003EРастворы для инъекций, в состав которых входят эпинефрин и норэпинефрин, не предназначены для в/в введения.\u003Cbr\u003EЛидокаин нельзя добавлять в переливаемую кровь.\u003Cbr\u003EВлияние на способность к вождению автотранспорта и управлению механизмами\u003Cbr\u003EПосле применения лидокаина не рекомендуется заниматься видами деятельности, требующими высокой концентрации внимания и быстрых психомоторных реакций."},{"name":"Взаимодействие","value":"При одновременном применении с барбитуратами (в т.ч. с фенобарбиталом) возможно повышение метаболизма лидокаина в печени, снижение концентрации в плазме крови и, вследствие этого, уменьшение его терапевтической эффективности.\u003Cbr\u003EПри одновременном применении с бета-адреноблокаторами (в т.ч. с пропранололом, надололом) возможно усиление эффектов лидокаина (в т.ч. токсических), по-видимому, вследствие замедления его метаболизма в печени.\u003Cbr\u003EПри одновременном применении с ингибиторами МАО возможно усиление местноанестезирующего действия лидокаина.\u003Cbr\u003EПри одновременном применении с препаратами, вызывающими блокаду нервно-мышечной передачи (в т.ч. с суксаметония хлоридом) возможно усиление действия препаратов, вызывающих блокаду нервно-мышечной передачи.\u003Cbr\u003EПри одновременном применении со снотворными и седативными средствами возможно усиление угнетающего действия на ЦНС; с аймалином, хинидином - возможно усиление кардиодепрессивного действия; с амиодароном - описаны случаи развития судорог и СССУ.\u003Cbr\u003EПри одновременном применении с гексеналом, тиопенталом натрия (в/в) возможно угнетение дыхания.\u003Cbr\u003EПри одновременном применении с мексилетином повышается токсичность лидокаина; с мидазоламом - умеренное уменьшение концентрации лидокаина в плазме крови; с морфином - усиление анальгезирующего эффекта морфина.\u003Cbr\u003EПри одновременном применении с прениламином развивается риск развития желудочковой аритмии типа \"пируэт\".\u003Cbr\u003EОписаны случаи возбуждения, галлюцинаций при одновременном применении с прокаинамидом.\u003Cbr\u003EПри одновременном применении с пропафеноном возможно увеличение продолжительности и повышение степени тяжести побочных эффектов со стороны ЦНС.\u003Cbr\u003EПолагают, что под влиянием рифампицина возможно уменьшение концентрации лидокаина в плазме крови.\u003Cbr\u003EПри одновременной в/в инфузии лидокаина и фенитоина возможно усиление побочных эффектов центрального генеза; описан случай синоатриальной блокады вследствие аддитивного кардиодепрессивного действия лидокаина и фенитоина.\u003Cbr\u003EУ пациентов, получающих фенитоин в качестве противосудорожного средства, возможно уменьшение концентрации лидокаина в плазме крови, что обусловлено индукцией микросомальных ферментов печени под влиянием фенитоина.\u003Cbr\u003EПри одновременном применении с циметидином умеренно уменьшается клиренс лидокаина и повышается его концентрация в плазме крови, имеется риск усиления побочного действия лидокаина."},{"name":"Регистрационный номер","value":"ЛП-003014"},{"name":"Дата государственной регистрации","value":"03.06.2020"},{"name":"Владелец регистрационного удостоверения","value":"Гротекс"},{"name":"Изготовитель","value":"Гротекс"},{"name":"Фасовщик","value":"Гротекс"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Лидокаин"},{"name":"Срок годности","value":"25 мес."}]}],"transitionId":"tr_937083012205826237"}}}}
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  • Лидокаин буфус р-р д/ин., 100 мг/мл, 2 мл, 10 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-cfszou8hdrf/toggleWishlist":{"skuId":"228046137","productId":1404816470,"offerId":"E97sOKLNJT6CO5BDj4VokQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ+cqMzruXtbphEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI1pjvnQUQuerebBjyrIIIINXlwQc=","sign":"QK3KHsyf6a9ZC4vSUw4L1o+kAFeFLtU313m8hCqxr74="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-cfszou8hdrf/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Лидокаин буфус р-р д/ин., 100 мг/мл, 2 мл, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 4 оценки
    Цена 174 ₽
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  • Лидокаин р-р д/ин., 20 мг/мл, 2 мл, 10 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-r5heuzdpqha/toggleWishlist":{"skuId":"665881000","productId":1404816437,"offerId":"8dB-lD_q7hOxq9tsfBBa4A","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ+cqMzruXtbphEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYItZjvnQUQqJPCvQIY6NzQByDV5cEH","sign":"K/jKWCp+8rYnmvNbwGpjXmeROy/6m99g1nnJjF9tepo="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-r5heuzdpqha/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Лидокаин р-р д/ин., 20 мг/мл, 2 мл, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 11 оценок
    Цена 72 ₽
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  • Лидокаин р-р д/ин., 20 мг/мл, 2 мл, 10 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-yfxujhp1q2b/toggleWishlist":{"skuId":"228048519","productId":1404816441,"offerId":"QF48Uvjsqp680CKsyWmfag","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ+cqMzruXtbphEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIuZjvnQUQh/3ebBiV3dAHINXlwQc=","sign":"8VQkid5ZeoBsF+IzExFMv3l6L6yllCxjHHai0ObmIHU="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-yfxujhp1q2b/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Лидокаин р-р д/ин., 20 мг/мл, 2 мл, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 32 оценки
    Цена 77 ₽
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  • Лидокаин р-р д/ин., 20 мг/мл, 2 мл, 10 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-e3l90tt6vjo/toggleWishlist":{"skuId":"228041478","productId":1778177953,"offerId":"FKg4VhwhOzJmLgqqQFHwUg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ+cqMzruXtbphEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIoa/zzwYQhsbebBidgc8GINXlwQc=","sign":"rs69R+IUwQ1iDUHkXk/SRNCGUz4AwTPh01Z9H6E0s0g="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-e3l90tt6vjo/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Лидокаин р-р д/ин., 20 мг/мл, 2 мл, 10 шт.

    Рейтинг товара: 4.7 из 5
    на основе 13 оценок
    Цена 54 ₽
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  • Лидокаин р-р д/ин., 20 мг/мл, 2 мл, 5 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-stbby052e2f/toggleWishlist":{"skuId":"101630469616","productId":453404083,"offerId":"hCbrhVGDWDfRPCqE9UO3OQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ+cqMzruXtbphEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIs8uZ2AEQ8MuXzfoCGOLc0Acg1eXBBw==","sign":"9yGLCW3XO5UuWNDjkF2YcYUaFlElX92O8CLqVTXx7UU="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-stbby052e2f/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Лидокаин р-р д/ин., 20 мг/мл, 2 мл, 5 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 34 ₽
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  • Лидокаин р-р д/ин., 20 мг/мл, 2 мл, 10 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-pael6puzpi/toggleWishlist":{"skuId":"228004223","productId":1778177950,"offerId":"Ngg4GN6vcuFVXMlLV2elSQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ+cqMzruXtbphEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUInq/zzwYQ/6LcbBj7lpAHINXlwQc=","sign":"CIYwe13wDji5wdoIsbK2fLzH3Tufi6li9Sdi9501usc="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-pael6puzpi/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Лидокаин р-р д/ин., 20 мг/мл, 2 мл, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 52 ₽
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  • Лидокаин р-р д/ин., 20 мг/мл, 2 мл, 10 шт.
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    Лидокаин р-р д/ин., 20 мг/мл, 2 мл, 10 шт.

    Рейтинг товара: 3 из 5
    на основе 4 оценки
    Цена 97 ₽
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  • Акриол Про крем д/мест. и нар. прим., 2,5%+2,5%, 5 г
    –1 %
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    Акриол Про крем д/мест. и нар. прим., 2,5%+2,5%, 5 г

    Рейтинг товара: 4.8 из 5
    на основе 116 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 299 ₽ вместо 302
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  • Эмла крем для мест. и нар. прим., 5 г, 1 шт.
    –1 %
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    Эмла крем для мест. и нар. прим., 5 г, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 13 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 696 ₽ вместо 703
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Инструкция

Показания к применению

В кардиологической практике: лечение и профилактика желудочковых аритмий (экстрасистолия, тахикардия, трепетание, фибрилляция), в т.ч. в остром периоде инфаркта миокарда, при имплантации искусственного водителя ритма, при гликозидной интоксикации, наркозе.
Для анестезии: терминальная, инфильтрационная, проводниковая, спинномозговая (эпидуральная) анестезия в хирургии, акушерстве и гинекологии, урологии, офтальмологии, стоматологии, оториноларингологии; блокада периферических нервов и нервных узлов.

Противопоказания

Тяжелые кровотечения, шок, артериальная гипотензия, инфицирование места предполагаемой инъекции, выраженная брадикардия, кардиогенный шок, тяжелые формы хронической сердечной недостаточности, СССУ у пациентов пожилого возраста, AV-блокада II и III степени (за исключением случаев, когда введен зонд для стимуляции желудочков), тяжелые нарушения функции печени.
Для субарахноидальной анестезии - полная блокада сердца, кровотечения, артериальная гипотензия, шок, инфицирование места проведения люмбальной пункции, септицемия.
Повышенная чувствительность к лидокаину и другим местным анестетикам амидного типа.

Способ применения и дозы

В качестве антиаритмического средства взрослым при введении нагрузочной дозы в/в - 1-2 мг/кг в течение 3-4 мин; средняя разовая доза 80 мг. Затем сразу переходят на капельную инфузию со скоростью 20-55 мкг/кг/мин. Капельную инфузию можно проводить в течение 24-36 ч. При необходимости на фоне капельной инфузии можно повторить в/в струйное введение лидокаина в дозе 40 мг через 10 мин после первой нагрузочной дозы.
В/м вводят по 2-4 мг/кг, при необходимости повторное введение возможно через 60-90 мин.
Детям при в/в введении нагрузочной дозы - 1 мг/кг, при необходимости возможно повторное введение через 5 мин. Для непрерывной в/в инфузии (обычно после введения нагрузочной дозы) - 20-30 мкг/кг/мин.
Для применения в хирургической и акушерской практике, стоматологии, ЛОР-практике режим дозирования устанавливают индивидуально, в зависимости от показаний, клинической ситуации и используемой лекарственной формы.
Максимальные дозы: взрослым при в/в введении нагрузочная доза - 100 мг, при последующей капельной инфузии - 2 мг/мин; при в/м введении - 300 мг (около 4.5 мг/кг) в течение 1 ч.
Детям в случае повторного введения нагрузочной дозы с интервалом 5 мин суммарная доза составляет 3 мг/кг; при непрерывной в/в инфузии (обычно после введения нагрузочной дозы) - 50 мкг/кг/мин.
Полная инструкция
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Лидокаин р-р д/ин.
Лидокаин р-р д/ин., 20 мг/мл, 2 мл, 10 шт.
5.0
(4)
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5 вопросов
Инструкция

119 ₽

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5.0
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