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Описание

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Сиофор таб. п/о плен., 850 мг, 60 шт.

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4.8
(18)
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Коротко о товаре

Артикул Маркета
3123173990
Тип препарата
Назначение
Действующее вещество
Возраст
от 10 лет
Инструкция
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у пациентов старше 60 лет, выполняющих тяжелую физическую работу, что связано с повышенным риском развития у них лактацидоза."},{"name":"Состав","value":"Действующее вещество: метформина гидрохлорид – 850 мг\u003Cbr\u003EВспомогательные вещества: гипромеллоза – 30 мг, повидон – 45 мг, магния стеарат – 5 мг\u003Cbr/\u003E"},{"name":"Действующее вещество","value":"Метформин","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-sakharnogo-diabeta","categoryId":"15756510","navnodeId":"72472","glfilters":["27144131:28708697"]}}},{"name":"Способ применения и дозы","value":"Препарат следует принимать внутрь во время или после еды.\u003Cbr\u003EДоза и режим приема препарата, а также продолжительность лечения устанавливаются лечащим врачом в зависимости от уровня глюкозы в крови.\u003Cbr\u003EВзрослые\u003Cbr\u003EМонотерапия\u003Cbr\u003EРекомендуемая начальная доза составляет 500 мг (1 таб. препарата Сиофор® 500 или 1/2 таб. препарата Сиофор® 1000) 1-2 раза/сут или 850 мг (1 таб. препарата Сиофор® 850) 1 раз/сут.\u003Cbr\u003EЧерез 10-15 дней после начала приема препарата возможно дальнейшее постепенное увеличение дозы в зависимости от уровня глюкозы в крови до средней суточной дозы: 3-4 таб. препарата Сиофор® 500, 2-3 таб. препарта Сиофор® 850 или 2 таб. препарата Сиофор® 1000. Постепенное увеличение дозы уменьшает количество нежелательных эффектов со стороны ЖКТ.\u003Cbr\u003EМаксимальная доза составляет 3000 мг/сут в 3 приема (6 таб. препарата Сиофор® 500 или 3 таб. препарата Сиофор® 1000).\u003Cbr\u003EДля пациентов, которым назначены высокие дозы (2000-3000 мг/сут) возможна замена 2 таб. препарата Сиофор® 500 на 1 таб. препарата Сиофор® 1000.\u003Cbr\u003EПри переводе пациента на лечение препаратом Сиофор® с терапии другим противодиабетическим лекарственным препаратом следует прекратить прием последнего и начать принимать препарат Сиофор® в указанных выше дозах.\u003Cbr\u003EКомбинированное применение с инсулином\u003Cbr\u003EПрепарат Сиофор® и инсулин можно комбинировать для улучшения гликемического контроля. Стандартная начальная доза составляет 500 мг (1 таб. препарата Сиофор® 500 или 1/2 таб. препарата Сиофор® 1000) 1-2 раза/сут или 850 мг (1 таб. препарата Сиофор® 850) 1 раз/сут, с постепенным повышением дозы с интервалом приблизительно в одну неделю до средней суточной дозы 3-4 таб. препарата Сиофор® 500, 2 таб. препарата Сиофор® 1000 или 2-3 таб. препарата Сиофор® 850; дозу инсулина определяют на основании концентрации глюкозы в крови.\u003Cbr\u003EМаксимальная доза составляет 3000 мг/сут в 3 приема.\u003Cbr\u003EВследствие возможного нарушения функции почек у пациентов пожилого возраста дозу препарата Сиофор® подбирают с учетом концентрации креатинина в плазме крови. Необходима регулярная оценка функционального состояния почек.\u003Cbr\u003EДети в возрасте от 10 до 18 лет\u003Cbr\u003EМонотерапия и комбинированное применение с инсулином\u003Cbr\u003EСтандартная начальная доза составляет 500 мг (1 таб. препарата Сиофор® 500 или 1/2 таб. препарата Сиофор® 1000) 1 раз/сут или 850 мг (1 таб. препарата Сиофор® 850) 1 раз/сут.\u003Cbr\u003EЧерез 10-15 дней после начала приема препарата возможно дальнейшее постепенное увеличение дозы в зависимости от уровня глюкозы в крови. Постепенное увеличение дозы уменьшает количество нежелательных эффектов со стороны ЖКТ.\u003Cbr\u003EМаксимальная доза для детей составляет 2000 мг/сут (4 таб. препарата Сиофор® 500 или 2 таб. препарата Сиофор® 1000) в 2-3 приема.\u003Cbr\u003EДозу инсулина определяют на основании уровня глюкозы в крови."},{"name":"Побочные действия","value":"Возможные побочные эффекты при применении препарата приведены в зависимости от частоты возникновения: часто (≥1/100, \u003C1/10), нечасто (≥1/1000, \u003C1/100), редко (≥1/10 000, \u003C1/1000), очень редко (\u003C1/10 000), включая отдельные сообщения.\u003Cbr\u003EСо стороны нервной системы: часто - нарушение вкуса.\u003Cbr\u003EСо стороны пищеварительной системы: тошнота, рвота, \"металлический\" привкус во рту, отсутствие аппетита, диарея, боли в животе. Эти нежелательные явления часто возникают в начале терапии и в большинстве случаев проходят самопроизвольно. Для предотвращения появления симптомов дозу препарата рекомендуется распределять на 2-3 приема во время или после еды. Постепенное увеличение дозы уменьшает вероятность появление нежелательных эффектов со стороны ЖКТ.\u003Cbr\u003EАллергические реакции: очень редко - кожные реакции (например, гиперемия, зуд, крапивница).\u003Cbr\u003EСо стороны обмена веществ: очень редко: - лактацидоз (требует прекращения лечения). При длительном применении наблюдается уменьшение всасывания витамина В12 и снижение его концентрации в плазме крови. Это следует учитывать при наличии у пациента мегалобластной анемии.\u003Cbr\u003EСо стороны печени и желчевыводящих путей: отдельные сообщения - обратимые нарушения функции печени, выражающиеся в повышении активности печеночных трансаминаз, или гепатит, проходящие после прекращения приема метформина."},{"name":"Фармакологическое действие","value":"Гипогликемический препарат из группы бигуанидов. Обеспечивает снижение как базальной, так и постпрандиальной концентрации глюкозы в крови. Не стимулирует секрецию инсулина и поэтому не приводит к гипогликемии. Действие метформина, вероятно, основывается на следующих механизмах:\u003Cbr\u003E— снижение выработки глюкозы в печени из-за угнетения глюконеогенеза и гликогенолиза;\u003Cbr\u003E— повышение чувствительности мышц к инсулину и, следовательно, улучшение поглощения глюкозы на периферии и ее утилизации;\u003Cbr\u003E— угнетение всасывания глюкозы в кишечнике.\u003Cbr\u003EМетформин посредством своего действия на гликогенсинтетазу стимулирует внутриклеточный синтез гликогена. Повышает транспортную емкость всех известных до настоящего времени мембранных транспортных протеинов глюкозы.\u003Cbr\u003EНезависимо от влияния на уровень глюкозы в крови, оказывает благоприятное действие на липидный обмен, приводит к снижению общего холестерина, холестерина низкой плотности и триглицеридов."},{"name":"Фармакологическая группа","value":"гипогликемическое средство для перорального применения группы бигуанидов"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-sakharnogo-diabeta","categoryId":"15756510","navnodeId":"72472","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 10 лет"},{"name":"Условия хранения","value":"Препарат следует хранить в недоступном для детей месте при температуре не выше 25°С. Срок годности - 3 года."},{"name":"Передозировка","value":"При применении метформина в дозах до 85 г гипогликемии не наблюдалось.\u003Cbr\u003EСимптомы: при значительной передозировке возможно развитие лактацидоза, симптомами которого являются выраженная слабость, респираторные нарушения, сонливость, тошнота, рвота, диарея, боли в животе, гипотермия, снижение АД, рефлекторная брадиаритмия. Могут отмечаться боли в мышцах, спутанность и потеря сознания.\u003Cbr\u003EЛечение: рекомендуется немедленная отмена препарата и экстренная госпитализация. Наиболее эффективный метод удаления лактата и метформина из организма - гемодиализ."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Применение препарата Сиофор 850 не вызывает гипогликемию, поэтому не влияет на способность к управлению транспортными средствами и обслуживанию механизмов.\u003Cbr\u003EПри одновременном применении препарата Сиофор 850 с другими гипогликемическими лекарственными средствами (производные сульфонилмочевины, инсулин, репаглинид), возможно развитие гипогликемических состояний, поэтому необходимо соблюдать осторожность при управлении транспортными средствами и другими потенциально опасными видами деятельности, требующих концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"Лактацидоз — серьезное патологическое состояние, встречающееся крайне редко, связанное с накоплением в крови молочной кислоты, причиной которого может стать кумуляция метформина. Описанные случаи развития лактацидоза у пациентов, получавших метформин, наблюдались преимущественно у пациентов с сахарным диабетом с выраженной почечной недостаточностью. Профилактика лактацидоза предполагает определение всех сопутствующих факторов риска, таких как декомпенсированный диабет, кетоз, длительное голодание, чрезмерное употребление алкоголя, печеночная недостаточность и любое состояние, связанное с гипоксией. При подозрении на развитие лактацидоза рекомендуется немедленная отмена препарата и экстренная госпитализация.\u003Cbr\u003EПоскольку метформин выводится почками, следует определять концентрацию креатинина в плазме крови перед началом лечения, а затем регулярно. Особую осторожность следует соблюдать в тех случаях, когда возникает риск нарушения функции почек, например, в начале терапии антигипертензивными препаратами, диуретиками или НПВС.\u003Cbr\u003EЛечение препаратом Сиофор® необходимо временно заменить терапией другими гипогликемическими препаратами (например, инсулином) за 48 ч до и 48 ч после проведения рентгенологического исследования с в/в введением йодсодержащих контрастных веществ.\u003Cbr\u003EПрименение препарата Сиофор® необходимо прекратить за 48 ч до плановой хирургической операции под общим наркозом, со спинальной или эпидуральной анестезией. Продолжить терапию следует после возобновления перорального питания или не ранее чем через 48 ч после хирургического вмешательства при условии подтверждения нормальной почечной функции.\u003Cbr\u003EСиофор® не заменяет диету и ежедневные физические упражнения — эти виды терапии необходимо сочетать в соответствии с рекомендациями врача. Во время лечения препаратом Сиофор® всем пациентам следует придерживаться диетического питания с равномерным потреблением углеводов в течение дня. Пациенты с избыточной массой тела должны соблюдать низкокалорийную диету.\u003Cbr\u003EСтандартные для больных сахарным диабетом лабораторные исследования необходимо проводить регулярно.\u003Cbr\u003EПеред применением препарата Сиофор® у детей в возрасте от 10 до 18 лет следует подтвердить диагноз сахарного диабета 2 типа.\u003Cbr\u003EВ ходе одногодичных контролируемых клинических исследований влияния метформина на рост и развитие, а также половое созревание детей не наблюдалось, данные по этим показателям при более длительном применении отсутствуют. В связи с этим рекомендуется тщательный контроль соответствующих параметров у детей, получающих метформин, особенно в препубертатный период (10-12 лет).\u003Cbr\u003EМонотерапия препаратом Сиофор® не приводит к гипогликемии, однако рекомендуется соблюдать осторожность при одновременном применении препарата с инсулином или производными сульфонилмочевины."},{"name":"Взаимодействие","value":"Противопоказанные комбинации\u003Cbr\u003EВнутрисосудистое введение йодсодержащих контрастных препаратов у пациентов с сахарным диабетом может осложниться почечной недостаточностью, вследствие чего метформин кумулирует и повышается риск развития лактацидоза. Применение препарата Сиофор® следует отменить за 48 ч до проведения и не возобновлять ранее чем через 2 дня после рентгенологического исследования с использованием йодсодержащих контрастных препаратов при условии нормальной концентрации сывороточного креатинина.\u003Cbr\u003EНерекомендуемые комбинации\u003Cbr\u003EРиск развития лактацидоза увеличивается при острой алкогольной интоксикации или одновременном применении с этанолсодержащими препаратами, особенно на фоне соблюдения диеты или нарушения питания, а также печеночной недостаточности.\u003Cbr\u003EКомбинации, требующие осторожности\u003Cbr\u003EОдновременное применение метформина с даназолом может привести к развитию гипергликемического эффекта. При необходимости лечения даназолом и после прекращения его применения требуется коррекция дозы метформина под контролем концентрации глюкозы в крови.\u003Cbr\u003EПри одновременном применении с пероральными контрацептивными препаратами, эпинефрином, глюкагоном, гормонами щитовидной железы, производными фенотиазина, никотиновой кислоты возможно повышение концентрации глюкозы в крови.\u003Cbr\u003EНифедипин повышает абсорбцию, Cmax в плазме крови метформина, пролонгирует его выведение.\u003Cbr\u003EКатионные препараты (амилорид, морфин, прокаинамид, хинидин, ранитидин, триамтерен, ванкомицин), секретирующиеся в канальцах, конкурируют за тубулярные транспортные системы и при длительной терапии могут увеличить Cmax метформина в плазме крови.\u003Cbr\u003EЦиметидин замедляет выведение препарата, вследствие чего увеличивается риск развития лактацидоза.\u003Cbr\u003EМетформин уменьшает Cmax и Т1/2 фуросемида.\u003Cbr\u003EМетформин может ослабить действие непрямых антикоагулянтов.\u003Cbr\u003EГлюкокортикоиды (для системного и местного применения), бета-адреномиметики и диуретики обладают гипергликемической активностью. Следует более тщательно контролировать концентрацию глюкозы в крови, особенно в начале лечения. При необходимости дозу метформина следует скорректировать на период одновременного применения и после отмены этих препаратов.\u003Cbr\u003EИнгибиторы АПФ и другие антигипертензивные лекарственные препараты могут снижать содержание глюкозы в крови. При необходимости доза метформина может быть скорректирована.\u003Cbr\u003EПри одновременном применении препарата Сиофор® с производными сульфонилмочевины, инсулином, акарбозой, салицилатами возможно усиление гипогликемического действия."},{"name":"Регистрационный номер","value":"П N013674/01"},{"name":"Дата государственной регистрации","value":"30.07.2019"},{"name":"Владелец регистрационного удостоверения","value":"Berlin-Chemie","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-sakharnogo-diabeta","categoryId":"15756510","navnodeId":"72472","glfilters":["34324371:35649313","7893318:16002727"]}}},{"name":"Страна бренда","value":"Германия"},{"name":"Страна-производитель","value":"Германия"},{"name":"Название препарата","value":"Сиофор","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-sakharnogo-diabeta","categoryId":"15756510","navnodeId":"72472","glfilters":["17796364:18045541"]}}},{"name":"Срок годности","value":"36 мес., при температуре не выше 25 °C."}]}},"fullSpecsGrouped":{"13057458443319354956":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"эндокринная система"},{"name":"Назначение","value":"сахарный диабет 2 типа"},{"name":"Показания к применению","value":"— сахарный диабет 2 типа, особенно у пациентов с избыточной массой тела при неэффективности диетотерапии и физических нагрузок.\u003Cbr\u003EВозможно применение в качестве монотерапии или в комбинации с другими пероральными гипогликемическими препаратами и инсулином."},{"name":"Противопоказания","value":"— диабетический кетоацидоз, диабетическая прекома;\u003Cbr\u003E— почечная недостаточность или нарушение почечной функции (КК \u003C60 мл/мин);\u003Cbr\u003E— острые состояния, способные оказать негативное влияние на функцию почек (например, дегидратация, тяжелое инфекционное заболевание);\u003Cbr\u003E— внутрисосудистое введение йодсодержащего контрастного вещества;\u003Cbr\u003E— острые или хронические заболевания, способные вызвать тканевую гипоксию (например, сердечная или дыхательная недостаточность, недавно перенесенный инфаркт миокарда, шок);\u003Cbr\u003E— печеночная недостаточность;\u003Cbr\u003E— лактацидоз (в т.ч. в анамнезе);\u003Cbr\u003E— беременность;\u003Cbr\u003E— период лактации (грудного вскармливания);\u003Cbr\u003E— острая алкогольная интоксикация, хронический алкоголизм;\u003Cbr\u003E— соблюдение низкокалорийной диеты (менее 1000 ккал/сут);\u003Cbr\u003E— детский возраст до 10 лет.\u003Cbr\u003E— повышенная чувствительность к метформину или другим компонентам препарата.\u003Cbr\u003EС осторожностью следует применять препарат у детей в возрасте от 10 до 12 лет; у пациентов старше 60 лет, выполняющих тяжелую физическую работу, что связано с повышенным риском развития у них лактацидоза."},{"name":"Состав","value":"Действующее вещество: метформина гидрохлорид – 850 мг\u003Cbr\u003EВспомогательные вещества: гипромеллоза – 30 мг, повидон – 45 мг, магния стеарат – 5 мг\u003Cbr/\u003E"},{"name":"Действующее вещество","value":"Метформин"},{"name":"Способ применения и дозы","value":"Препарат следует принимать внутрь во время или после еды.\u003Cbr\u003EДоза и режим приема препарата, а также продолжительность лечения устанавливаются лечащим врачом в зависимости от уровня глюкозы в крови.\u003Cbr\u003EВзрослые\u003Cbr\u003EМонотерапия\u003Cbr\u003EРекомендуемая начальная доза составляет 500 мг (1 таб. препарата Сиофор® 500 или 1/2 таб. препарата Сиофор® 1000) 1-2 раза/сут или 850 мг (1 таб. препарата Сиофор® 850) 1 раз/сут.\u003Cbr\u003EЧерез 10-15 дней после начала приема препарата возможно дальнейшее постепенное увеличение дозы в зависимости от уровня глюкозы в крови до средней суточной дозы: 3-4 таб. препарата Сиофор® 500, 2-3 таб. препарта Сиофор® 850 или 2 таб. препарата Сиофор® 1000. Постепенное увеличение дозы уменьшает количество нежелательных эффектов со стороны ЖКТ.\u003Cbr\u003EМаксимальная доза составляет 3000 мг/сут в 3 приема (6 таб. препарата Сиофор® 500 или 3 таб. препарата Сиофор® 1000).\u003Cbr\u003EДля пациентов, которым назначены высокие дозы (2000-3000 мг/сут) возможна замена 2 таб. препарата Сиофор® 500 на 1 таб. препарата Сиофор® 1000.\u003Cbr\u003EПри переводе пациента на лечение препаратом Сиофор® с терапии другим противодиабетическим лекарственным препаратом следует прекратить прием последнего и начать принимать препарат Сиофор® в указанных выше дозах.\u003Cbr\u003EКомбинированное применение с инсулином\u003Cbr\u003EПрепарат Сиофор® и инсулин можно комбинировать для улучшения гликемического контроля. Стандартная начальная доза составляет 500 мг (1 таб. препарата Сиофор® 500 или 1/2 таб. препарата Сиофор® 1000) 1-2 раза/сут или 850 мг (1 таб. препарата Сиофор® 850) 1 раз/сут, с постепенным повышением дозы с интервалом приблизительно в одну неделю до средней суточной дозы 3-4 таб. препарата Сиофор® 500, 2 таб. препарата Сиофор® 1000 или 2-3 таб. препарата Сиофор® 850; дозу инсулина определяют на основании концентрации глюкозы в крови.\u003Cbr\u003EМаксимальная доза составляет 3000 мг/сут в 3 приема.\u003Cbr\u003EВследствие возможного нарушения функции почек у пациентов пожилого возраста дозу препарата Сиофор® подбирают с учетом концентрации креатинина в плазме крови. Необходима регулярная оценка функционального состояния почек.\u003Cbr\u003EДети в возрасте от 10 до 18 лет\u003Cbr\u003EМонотерапия и комбинированное применение с инсулином\u003Cbr\u003EСтандартная начальная доза составляет 500 мг (1 таб. препарата Сиофор® 500 или 1/2 таб. препарата Сиофор® 1000) 1 раз/сут или 850 мг (1 таб. препарата Сиофор® 850) 1 раз/сут.\u003Cbr\u003EЧерез 10-15 дней после начала приема препарата возможно дальнейшее постепенное увеличение дозы в зависимости от уровня глюкозы в крови. Постепенное увеличение дозы уменьшает количество нежелательных эффектов со стороны ЖКТ.\u003Cbr\u003EМаксимальная доза для детей составляет 2000 мг/сут (4 таб. препарата Сиофор® 500 или 2 таб. препарата Сиофор® 1000) в 2-3 приема.\u003Cbr\u003EДозу инсулина определяют на основании уровня глюкозы в крови."},{"name":"Побочные действия","value":"Возможные побочные эффекты при применении препарата приведены в зависимости от частоты возникновения: часто (≥1/100, \u003C1/10), нечасто (≥1/1000, \u003C1/100), редко (≥1/10 000, \u003C1/1000), очень редко (\u003C1/10 000), включая отдельные сообщения.\u003Cbr\u003EСо стороны нервной системы: часто - нарушение вкуса.\u003Cbr\u003EСо стороны пищеварительной системы: тошнота, рвота, \"металлический\" привкус во рту, отсутствие аппетита, диарея, боли в животе. Эти нежелательные явления часто возникают в начале терапии и в большинстве случаев проходят самопроизвольно. Для предотвращения появления симптомов дозу препарата рекомендуется распределять на 2-3 приема во время или после еды. Постепенное увеличение дозы уменьшает вероятность появление нежелательных эффектов со стороны ЖКТ.\u003Cbr\u003EАллергические реакции: очень редко - кожные реакции (например, гиперемия, зуд, крапивница).\u003Cbr\u003EСо стороны обмена веществ: очень редко: - лактацидоз (требует прекращения лечения). При длительном применении наблюдается уменьшение всасывания витамина В12 и снижение его концентрации в плазме крови. Это следует учитывать при наличии у пациента мегалобластной анемии.\u003Cbr\u003EСо стороны печени и желчевыводящих путей: отдельные сообщения - обратимые нарушения функции печени, выражающиеся в повышении активности печеночных трансаминаз, или гепатит, проходящие после прекращения приема метформина."},{"name":"Фармакологическое действие","value":"Гипогликемический препарат из группы бигуанидов. Обеспечивает снижение как базальной, так и постпрандиальной концентрации глюкозы в крови. Не стимулирует секрецию инсулина и поэтому не приводит к гипогликемии. Действие метформина, вероятно, основывается на следующих механизмах:\u003Cbr\u003E— снижение выработки глюкозы в печени из-за угнетения глюконеогенеза и гликогенолиза;\u003Cbr\u003E— повышение чувствительности мышц к инсулину и, следовательно, улучшение поглощения глюкозы на периферии и ее утилизации;\u003Cbr\u003E— угнетение всасывания глюкозы в кишечнике.\u003Cbr\u003EМетформин посредством своего действия на гликогенсинтетазу стимулирует внутриклеточный синтез гликогена. Повышает транспортную емкость всех известных до настоящего времени мембранных транспортных протеинов глюкозы.\u003Cbr\u003EНезависимо от влияния на уровень глюкозы в крови, оказывает благоприятное действие на липидный обмен, приводит к снижению общего холестерина, холестерина низкой плотности и триглицеридов."},{"name":"Фармакологическая группа","value":"гипогликемическое средство для перорального применения группы бигуанидов"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 10 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Препарат следует хранить в недоступном для детей месте при температуре не выше 25°С. Срок годности - 3 года."},{"name":"Передозировка","value":"При применении метформина в дозах до 85 г гипогликемии не наблюдалось.\u003Cbr\u003EСимптомы: при значительной передозировке возможно развитие лактацидоза, симптомами которого являются выраженная слабость, респираторные нарушения, сонливость, тошнота, рвота, диарея, боли в животе, гипотермия, снижение АД, рефлекторная брадиаритмия. Могут отмечаться боли в мышцах, спутанность и потеря сознания.\u003Cbr\u003EЛечение: рекомендуется немедленная отмена препарата и экстренная госпитализация. Наиболее эффективный метод удаления лактата и метформина из организма - гемодиализ."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Применение препарата Сиофор 850 не вызывает гипогликемию, поэтому не влияет на способность к управлению транспортными средствами и обслуживанию механизмов.\u003Cbr\u003EПри одновременном применении препарата Сиофор 850 с другими гипогликемическими лекарственными средствами (производные сульфонилмочевины, инсулин, репаглинид), возможно развитие гипогликемических состояний, поэтому необходимо соблюдать осторожность при управлении транспортными средствами и другими потенциально опасными видами деятельности, требующих концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"Лактацидоз — серьезное патологическое состояние, встречающееся крайне редко, связанное с накоплением в крови молочной кислоты, причиной которого может стать кумуляция метформина. Описанные случаи развития лактацидоза у пациентов, получавших метформин, наблюдались преимущественно у пациентов с сахарным диабетом с выраженной почечной недостаточностью. Профилактика лактацидоза предполагает определение всех сопутствующих факторов риска, таких как декомпенсированный диабет, кетоз, длительное голодание, чрезмерное употребление алкоголя, печеночная недостаточность и любое состояние, связанное с гипоксией. При подозрении на развитие лактацидоза рекомендуется немедленная отмена препарата и экстренная госпитализация.\u003Cbr\u003EПоскольку метформин выводится почками, следует определять концентрацию креатинина в плазме крови перед началом лечения, а затем регулярно. Особую осторожность следует соблюдать в тех случаях, когда возникает риск нарушения функции почек, например, в начале терапии антигипертензивными препаратами, диуретиками или НПВС.\u003Cbr\u003EЛечение препаратом Сиофор® необходимо временно заменить терапией другими гипогликемическими препаратами (например, инсулином) за 48 ч до и 48 ч после проведения рентгенологического исследования с в/в введением йодсодержащих контрастных веществ.\u003Cbr\u003EПрименение препарата Сиофор® необходимо прекратить за 48 ч до плановой хирургической операции под общим наркозом, со спинальной или эпидуральной анестезией. Продолжить терапию следует после возобновления перорального питания или не ранее чем через 48 ч после хирургического вмешательства при условии подтверждения нормальной почечной функции.\u003Cbr\u003EСиофор® не заменяет диету и ежедневные физические упражнения — эти виды терапии необходимо сочетать в соответствии с рекомендациями врача. Во время лечения препаратом Сиофор® всем пациентам следует придерживаться диетического питания с равномерным потреблением углеводов в течение дня. Пациенты с избыточной массой тела должны соблюдать низкокалорийную диету.\u003Cbr\u003EСтандартные для больных сахарным диабетом лабораторные исследования необходимо проводить регулярно.\u003Cbr\u003EПеред применением препарата Сиофор® у детей в возрасте от 10 до 18 лет следует подтвердить диагноз сахарного диабета 2 типа.\u003Cbr\u003EВ ходе одногодичных контролируемых клинических исследований влияния метформина на рост и развитие, а также половое созревание детей не наблюдалось, данные по этим показателям при более длительном применении отсутствуют. В связи с этим рекомендуется тщательный контроль соответствующих параметров у детей, получающих метформин, особенно в препубертатный период (10-12 лет).\u003Cbr\u003EМонотерапия препаратом Сиофор® не приводит к гипогликемии, однако рекомендуется соблюдать осторожность при одновременном применении препарата с инсулином или производными сульфонилмочевины."},{"name":"Взаимодействие","value":"Противопоказанные комбинации\u003Cbr\u003EВнутрисосудистое введение йодсодержащих контрастных препаратов у пациентов с сахарным диабетом может осложниться почечной недостаточностью, вследствие чего метформин кумулирует и повышается риск развития лактацидоза. Применение препарата Сиофор® следует отменить за 48 ч до проведения и не возобновлять ранее чем через 2 дня после рентгенологического исследования с использованием йодсодержащих контрастных препаратов при условии нормальной концентрации сывороточного креатинина.\u003Cbr\u003EНерекомендуемые комбинации\u003Cbr\u003EРиск развития лактацидоза увеличивается при острой алкогольной интоксикации или одновременном применении с этанолсодержащими препаратами, особенно на фоне соблюдения диеты или нарушения питания, а также печеночной недостаточности.\u003Cbr\u003EКомбинации, требующие осторожности\u003Cbr\u003EОдновременное применение метформина с даназолом может привести к развитию гипергликемического эффекта. При необходимости лечения даназолом и после прекращения его применения требуется коррекция дозы метформина под контролем концентрации глюкозы в крови.\u003Cbr\u003EПри одновременном применении с пероральными контрацептивными препаратами, эпинефрином, глюкагоном, гормонами щитовидной железы, производными фенотиазина, никотиновой кислоты возможно повышение концентрации глюкозы в крови.\u003Cbr\u003EНифедипин повышает абсорбцию, Cmax в плазме крови метформина, пролонгирует его выведение.\u003Cbr\u003EКатионные препараты (амилорид, морфин, прокаинамид, хинидин, ранитидин, триамтерен, ванкомицин), секретирующиеся в канальцах, конкурируют за тубулярные транспортные системы и при длительной терапии могут увеличить Cmax метформина в плазме крови.\u003Cbr\u003EЦиметидин замедляет выведение препарата, вследствие чего увеличивается риск развития лактацидоза.\u003Cbr\u003EМетформин уменьшает Cmax и Т1/2 фуросемида.\u003Cbr\u003EМетформин может ослабить действие непрямых антикоагулянтов.\u003Cbr\u003EГлюкокортикоиды (для системного и местного применения), бета-адреномиметики и диуретики обладают гипергликемической активностью. Следует более тщательно контролировать концентрацию глюкозы в крови, особенно в начале лечения. При необходимости дозу метформина следует скорректировать на период одновременного применения и после отмены этих препаратов.\u003Cbr\u003EИнгибиторы АПФ и другие антигипертензивные лекарственные препараты могут снижать содержание глюкозы в крови. При необходимости доза метформина может быть скорректирована.\u003Cbr\u003EПри одновременном применении препарата Сиофор® с производными сульфонилмочевины, инсулином, акарбозой, салицилатами возможно усиление гипогликемического действия."},{"name":"Регистрационный номер","value":"П N013674/01"},{"name":"Дата государственной регистрации","value":"30.07.2019"},{"name":"Владелец регистрационного удостоверения","value":"Berlin-Chemie"},{"name":"Страна бренда","value":"Германия"},{"name":"Страна-производитель","value":"Германия"},{"name":"Название препарата","value":"Сиофор"},{"name":"Срок годности","value":"36 мес., при температуре не выше 25 °C."}]}],"transitionId":"tr_18111872295629701214"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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  • Олиджим таб., 30 г, 100 шт.
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    Олиджим таб., 30 г, 100 шт.

    Рейтинг товара: 4.6 из 5
    на основе 1463 оценки
    Цена 508 ₽ вместо 599
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  • Сиофор таб. п/о плен., 1000 мг, 60 шт.
    –20 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-i6mfxnbf2md/toggleWishlist":{"skuId":"101372395736","productId":656559067,"offerId":"CHfVUpaRDnonKOuJ9LezBA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhtrfkbTAofFAEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI25eJuQIQ2IGQ0vkCGKfd0Acg3tnBBw==","sign":"1LbeduO/VEnR8d+7FoAc1CtcHwa0AMimPNUpi3qVUWA="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-i6mfxnbf2md/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Сиофор таб. п/о плен., 1000 мг, 60 шт.

    Рейтинг товара: 4.8 из 5
    на основе 39 оценок
    Цена 209 ₽ вместо 261
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-i6mfxnbf2md/addToCartButton":{"offerId":"CHfVUpaRDnonKOuJ9LezBA","skuId":"101372395736","pendingCartItem":{"productId":656559067,"offerId":"CHfVUpaRDnonKOuJ9LezBA","showPlaceId":"OTNDnItfwRMjN9MRHuEMMjfOmlqzCpBlIWV7TtYu46Po4_LKUsxdopl9IlVM776NlBl80HUaqpslv3UutKz9WZOTXkpFt7AQ6vvGYF8WWRbM0nehq83mRRCe513aPJtRYeUbgKA8j7PQgysSPr8oet72Cr9k4CG_BwQnFpmA2suPZasEZdTycrzy3lSzzSBQTXXGeIxQsBxNS2zwMzhMzg,,","feeShow":"OTNDnItfwRMjN9MRHuEMMjfOmlqzCpBlIWV7TtYu46Po4_LKUsxdopl9IlVM776NlBl80HUaqpslv3UutKz9WZOTXkpFt7AQ6vvGYF8WWRbM0nehq83mRRCe513aPJtRYeUbgKA8j7PQgysSPr8oet72Cr9k4CG_BwQnFpmA2suPZasEZdTycrzy3lSzzSBQTXXGeIxQsBxNS2zwMzhMzg,,","skuId":"101372395736","shopId":55106433,"price":{"applicablePriceDiscounts":[],"discount":{"oldMin":"261","percent":20},"value":"209","currency":"RUR"},"hid":"15756510","name":"Сиофор таб. п/о плен., 1000 мг, 60 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  • Глюкофаж лонг таб. пролонг. действ., 1000 мг, 60 шт.
    –17 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-txa1z90u4ed/toggleWishlist":{"skuId":"228004154","productId":998360030,"offerId":"q1dnZBUfLn7VRjUKZIs7FQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhtrfkbTAofFAEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI3oeH3AMQuqLcbBjozocEIN7ZwQc=","sign":"J+y6k/GRyKHAHOhnf66cM62F3GYzG+X1VqSdB5jtAhg="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-txa1z90u4ed/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Глюкофаж лонг таб. пролонг. действ., 1000 мг, 60 шт.

    Рейтинг товара: 4.8 из 5
    на основе 51 оценка
    Цена 696 ₽ вместо 842
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  • Метформин-Тева таб. п/о плен., 1000 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-5mkzf3ahf3e/toggleWishlist":{"skuId":"186868784","productId":998360013,"offerId":"bzFUUJO5otl3sXeywRNxZw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhtrfkbTAofFAEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIzYeH3AMQsMiNWRjW/Y0HIN7ZwQc=","sign":"SxKVCT+86mHch3hhD/QBBlNKxJJd/rhZZErdC+Q4ug0="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-5mkzf3ahf3e/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Метформин-Тева таб. п/о плен., 1000 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 22 оценки
    Цена 99 ₽
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  • Метформин таб., 500 мг, 60 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ik7e8fjqd6/toggleWishlist":{"skuId":"228007866","productId":998360039,"offerId":"AQXbkQZOTUoicoRgtfiSNw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhtrfkbTAofFAEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI54eH3AMQur/cbBiEqbIIIN7ZwQc=","sign":"AO8Vpc4Ke7OCS5yGhGQuS6rWfqCvXcIHPqkzvna2VhQ="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ik7e8fjqd6/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Метформин таб., 500 мг, 60 шт.

    Рейтинг товара: 4.7 из 5
    на основе 68 оценок
    Цена 102 ₽
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  • Глюкофаж Лонг таб. пролонг. действ., 750 мг, 30 шт.
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    Глюкофаж Лонг таб. пролонг. действ., 750 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 10 оценок
    Цена 292 ₽
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  • Глюкофаж Лонг таб. пролонг. действ., 500 мг, 60 шт.
    –12 %
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    Глюкофаж Лонг таб. пролонг. действ., 500 мг, 60 шт.

    Рейтинг товара: 4.8 из 5
    на основе 20 оценок
    Цена 388 ₽ вместо 442
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  • Глюконорм таб. п/о плен., 2.5 мг+400 мг, 40 шт.
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    Глюконорм таб. п/о плен., 2.5 мг+400 мг, 40 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 343 ₽
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  • Мерифатин таб. п/о плен., 500 мг, 60 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-bajib5k30mh/toggleWishlist":{"skuId":"228052491","productId":998360032,"offerId":"OZUPCb3pIz3Oq9SsL1y8rA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhtrfkbTAofFAEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI4IeH3AMQi5zfbBjso7MIIN7ZwQc=","sign":"1SPctvACSpof4yOuzMKah69tX8eNTK8zEUNvf5pGqOM="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-bajib5k30mh/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Мерифатин таб. п/о плен., 500 мг, 60 шт.

    Рейтинг товара: 5 из 5
    на основе 6 оценок
    Цена 97 ₽
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  • Диабетон МВ таб. модиф. высвоб., 60 мг, 30 шт.
    –20 %
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    Диабетон МВ таб. модиф. высвоб., 60 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 13 оценок
    Цена 245 ₽ вместо 306
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  • Метформин-СЗ таб. пролонг. высвоб., 750 мг, 60 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-wt24xxh23b/toggleWishlist":{"skuId":"101531083153","productId":1490735927,"offerId":"8MYqAvq53buIsQw1M18LIw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhtrfkbTAofFAEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIt6brxgUQkcPlnfoCGK7e0Acg3tnBBw==","sign":"uqMHZcGu5mBjRdoINBuwVWJuwG6uqgPX3zpH5bwi0Wc="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-wt24xxh23b/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Метформин-СЗ таб. пролонг. высвоб., 750 мг, 60 шт.

    Рейтинг товара: 5 из 5
    на основе 12 оценок
    Цена 306 ₽
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  • Форметин таб., 0.5 г, 60 шт.
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    Форметин таб., 0.5 г, 60 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 117 ₽
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Инструкция

Показания к применению

— сахарный диабет 2 типа, особенно у пациентов с избыточной массой тела при неэффективности диетотерапии и физических нагрузок.
Возможно применение в качестве монотерапии или в комбинации с другими пероральными гипогликемическими препаратами и инсулином.

Противопоказания

— диабетический кетоацидоз, диабетическая прекома;
— почечная недостаточность или нарушение почечной функции (КК <60 мл/мин);
— острые состояния, способные оказать негативное влияние на функцию почек (например, дегидратация, тяжелое инфекционное заболевание);
— внутрисосудистое введение йодсодержащего контрастного вещества;
— острые или хронические заболевания, способные вызвать тканевую гипоксию (например, сердечная или дыхательная недостаточность, недавно перенесенный инфаркт миокарда, шок);
— печеночная недостаточность;
— лактацидоз (в т.ч. в анамнезе);
— беременность;
— период лактации (грудного вскармливания);
— острая алкогольная интоксикация, хронический алкоголизм;
— соблюдение низкокалорийной диеты (менее 1000 ккал/сут);
— детский возраст до 10 лет.
— повышенная чувствительность к метформину или другим компонентам препарата.
С осторожностью следует применять препарат у детей в возрасте от 10 до 12 лет; у пациентов старше 60 лет, выполняющих тяжелую физическую работу, что связано с повышенным риском развития у них лактацидоза.

Способ применения и дозы

Препарат следует принимать внутрь во время или после еды.
Доза и режим приема препарата, а также продолжительность лечения устанавливаются лечащим врачом в зависимости от уровня глюкозы в крови.
Взрослые
Монотерапия
Рекомендуемая начальная доза составляет 500 мг (1 таб. препарата Сиофор® 500 или 1/2 таб. препарата Сиофор® 1000) 1-2 раза/сут или 850 мг (1 таб. препарата Сиофор® 850) 1 раз/сут.
Через 10-15 дней после начала приема препарата возможно дальнейшее постепенное увеличение дозы в зависимости от уровня глюкозы в крови до средней суточной дозы: 3-4 таб. препарата Сиофор® 500, 2-3 таб. препарта Сиофор® 850 или 2 таб. препарата Сиофор® 1000. Постепенное увеличение дозы уменьшает количество нежелательных эффектов со стороны ЖКТ.
Максимальная доза составляет 3000 мг/сут в 3 приема (6 таб. препарата Сиофор® 500 или 3 таб. препарата Сиофор® 1000).
Для пациентов, которым назначены высокие дозы (2000-3000 мг/сут) возможна замена 2 таб. препарата Сиофор® 500 на 1 таб. препарата Сиофор® 1000.
При переводе пациента на лечение препаратом Сиофор® с терапии другим противодиабетическим лекарственным препаратом следует прекратить прием последнего и начать принимать препарат Сиофор® в указанных выше дозах.
Комбинированное применение с инсулином
Препарат Сиофор® и инсулин можно комбинировать для улучшения гликемического контроля. Стандартная начальная доза составляет 500 мг (1 таб. препарата Сиофор® 500 или 1/2 таб. препарата Сиофор® 1000) 1-2 раза/сут или 850 мг (1 таб. препарата Сиофор® 850) 1 раз/сут, с постепенным повышением дозы с интервалом приблизительно в одну неделю до средней суточной дозы 3-4 таб. препарата Сиофор® 500, 2 таб. препарата Сиофор® 1000 или 2-3 таб. препарата Сиофор® 850; дозу инсулина определяют на основании концентрации глюкозы в крови.
Максимальная доза составляет 3000 мг/сут в 3 приема.
Вследствие возможного нарушения функции почек у пациентов пожилого возраста дозу препарата Сиофор® подбирают с учетом концентрации креатинина в плазме крови. Необходима регулярная оценка функционального состояния почек.
Дети в возрасте от 10 до 18 лет
Монотерапия и комбинированное применение с инсулином
Стандартная начальная доза составляет 500 мг (1 таб. препарата Сиофор® 500 или 1/2 таб. препарата Сиофор® 1000) 1 раз/сут или 850 мг (1 таб. препарата Сиофор® 850) 1 раз/сут.
Через 10-15 дней после начала приема препарата возможно дальнейшее постепенное увеличение дозы в зависимости от уровня глюкозы в крови. Постепенное увеличение дозы уменьшает количество нежелательных эффектов со стороны ЖКТ.
Максимальная доза для детей составляет 2000 мг/сут (4 таб. препарата Сиофор® 500 или 2 таб. препарата Сиофор® 1000) в 2-3 приема.
Дозу инсулина определяют на основании уровня глюкозы в крови.
Полная инструкция
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Сиофор таб. п/о плен.
Сиофор таб. п/о плен., 850 мг, 60 шт.
4.8
(18)
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1 вопрос
Инструкция

174 ₽

Скидка: 18%
–18 %
Вместо:211 ₽
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4.8
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У продавца:18 оценок·3 отзыва
У всех продавцов:43 оценки·16 отзывов
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user avatar
3 месяца назад • From USSR 66 • Куплен на Маркете
Достоинства: действующий состав соответствует рецепту
Недостатки: побочные эффекты соответствуют указанным в инструкции
Комментарий: если бы не диабет, ни за что не купил бы!
user avatar
3 месяца назад • Алексей Ж. • Куплен на Маркете
Достоинства: соотношени цена-качество
Недостатки: нет
Комментарий: лучший Метформин, из имеющихся в продаже
user avatar
5 месяцев назад • ЛЛюдмила Бахтеева • Куплен на Маркете
Достоинства: работает
Посмотреть все отзывы на Маркете
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