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Гептрал таб. п/о кш/раств., 400 мг, 20 шт.

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4.9
(196)
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Коротко о товаре

Артикул Маркета
3123129836
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
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противоопухолевые, противотуберкулезные и противовирусные препараты, трициклические антидепрессанты, пероральные контрацептивы);\u003Cbr\u003E- хронический бескаменный холецистит;\u003Cbr\u003E- холангит;\u003Cbr\u003E- цирроз печени;\u003Cbr\u003E- энцефалопатия, в т.ч. ассоциированная с печеночной недостаточностью (алкогольная и др.).\u003Cbr\u003E- Внутрипеченочный холестаз у беременных.\u003Cbr\u003E- Симптомы депрессии.\u003Cbr\u003E- Повышенная утомляемость при хронических заболеваниях печени."},{"name":"Противопоказания","value":"Генетические нарушения, влияющие на метиониновый цикл, и/или вызывающие гомоцистинурию и/или гипергомоцистеинемию (дефицит цистатионин бетасинтазы, нарушение метаболизма витамина В12).\u003Cbr\u003EГиперчувствительность к любому из компонентов препарата.\u003Cbr\u003EВозраст до 18 лет (опыт медицинского применения у детей ограничен).\u003Cbr\u003EБиполярные расстройства."},{"name":"Состав","value":"Каждая таблетка содержит:\u003Cbr\u003EДействующее вещество: адеметионина 1,4-бутандисульфонат 760 мг (соответствует 400 мг иона адеметионина).\u003Cbr\u003EВспомогательные вещества: кремния диоксид коллоидный - 4,4 мг, целлюлоза микрокристаллическая - 93,6 мг, карбоксиметилкрахмал натрия (тип А) - 17,6 мг, магния стеарат - 4,4 мг;\u003Cbr\u003Eоболочка таблетки: метакриловой кислоты и этилакрилата сополимер (1:1) - 27,6 мг, макрогол-6000 - 8,07 мг, полисорбат-80 - 0,44 мг, симетикон (эмульсия 30%) - 0,13 мг, натрия гидроксид - 0,36 мг, тальк - 18,4 мг, вода - Q.S."},{"name":"Действующее вещество","value":"Адеметионин","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["27144131:28710768"]}}},{"name":"Способ применения и дозы","value":"Внутрь. Таблетки следует принимать целиком, не разжевывая, желательно в первой половине дня между приемами пищи.\u003Cbr\u003EТаблетки препарата Гептрал следует вынимать из блистера непосредственно перед приемом внутрь. В случае, если таблетки имеют цвет, отличный от белого до белого с желтоватым оттенком (вследствие негерметичности алюминиевой фольги), препарат Гептрал использовать не рекомендуется.\u003Cbr\u003EНачальная терапия\u003Cbr\u003EРекомендуемая доза составляет 10-25 мг/кг/сут внутрь.\u003Cbr\u003EВнутрипеченочный холестаз повышенная утомляемость при хронических заболеваниях печени\u003Cbr\u003EДоза составляет от 800 мг/сут до 1600 мг/сут.\u003Cbr\u003EДепрессия\u003Cbr\u003EДоза составляет от 800 мг/сут до 1600 мг/сут.\u003Cbr\u003EДлительность терапии определяется врачом.\u003Cbr\u003EТерапия препаратом Гептрал может быть начата с внутривенного или внутримышечного введения с последующим применением препарата Гептрал в виде таблеток или сразу с применения препарата Гептрал в виде таблеток.\u003Cbr\u003EПациенты пожилого возраста\u003Cbr\u003EКлинический опыт применения препарата Гептрал не выявил каких-либо различий в его эффективности у пациентов пожилого возраста и пациентов более молодого возраста. Однако, учитывая высокую вероятность имеющихся нарушений функции печени, почек или сердца, другой сопутствующей патологии или одновременной терапии с другими лекарственными средствами, дозу препарата Гептрал пожилым пациентам следует подбирать с осторожностью, начиная применение препарата с нижнего предела диапазона доз.\u003Cbr\u003EПочечная недостаточность\u003Cbr\u003EИмеются ограниченные клинические данные о применении препарата Гептрал у пациентов с почечной недостаточностью, в связи с этим рекомендуется соблюдать осторожность при применении препарата Гептрал у таких пациентов.\u003Cbr\u003EПеченочная недостаточность\u003Cbr\u003EПараметры фармакокинетики адеметионина сходны у здоровых добровольцев и у пациентов с хроническими заболеваниями печени.\u003Cbr\u003EДети\u003Cbr\u003EПрименение препарата Гептрал у детей противопоказано (эффективность и безопасность не установлены)."},{"name":"Побочные действия","value":"Со стороны пищеварительной системы: часто - тошнота, боли в животе, диарея; редко - рвота, сухость во рту, эзофагит, диспепсия, метеоризм, желудочно-кишечная боль, желудочно-кишечное кровотечение, печеночная колика.\u003Cbr\u003EСо стороны нервной системы: редко - спутанность сознания, бессонница, головокружение, головная боль, парестезии.\u003Cbr\u003EСо стороны костно-мышечной системы: редко - артралгии, мышечные судороги.\u003Cbr\u003EСо стороны мочевыделительной системы: редко - инфекции мочевыводящих путей.\u003Cbr\u003EСо стороны кожных покровов: редко - гипергидроз, зуд, кожная сыпь.\u003Cbr\u003EМестные реакции: редко - реакции в месте введения; очень редко - реакции в месте введения, некроз кожи в месте введения.\u003Cbr\u003EАллергические реакции: редко - анафилактические реакции; очень редко - отек Квинке, отек гортани.\u003Cbr\u003EПрочие: редко - приливы, поверхностный флебит, астения, озноб, гриппоподобные симптомы, слабость, периферические отеки, гипертермия."},{"name":"Фармакологическое действие","value":"Адеметионин относится к группе гепатопротекторов, обладает также антидепрессивной активностью.\u003Cbr\u003EОказывает холеретическое и холекинетическое действие, обладает детоксикационными, регенерирующими, антиоксидантными, антифиброзирующими и нейропротективными свойствами.\u003Cbr\u003EВосполняет дефицит S-аденозил-L-метионина (адеметионина) и стимулирует его выработку в организме, содержится во всех средах организма. Наибольшая концентрация адеметионина отмечена в печени и мозге.\u003Cbr\u003EВыполняет ключевую роль в метаболических процессах организма, принимает участие в важных биохимических реакциях: трансметилировании, транссульфурировании, трансаминировании. В реакциях трансметилирования адеметионин донирует метальную группу для синтеза фосфолипидов клеточных мембран, нейротрансмиттеров, нуклеиновых кислот, белков, гормонов и др. В реакциях транссульфурирования адеметионин является предшественником цистеина, таурина, глютатиона (обеспечивая окислительно-восстановительный механизм клеточной детоксикации), коэнзима А (включается в биохимические реакции цикла трикарбоновых кислот и восполняет энергетический потенциал клетки).\u003Cbr\u003EПовышает содержание глутамина в печени, цистеина и таурина в плазме; снижает содержание метионина в сыворотке, нормализуя метаболические реакции в печени. После декарбоксилирования участвует в реакциях аминопропилирования, как предшественник полиаминов путресцина (стимулятор регенерации клеток и пролиферации гепатоцитов), спермидина и спермина, входящих в структуру рибосом, что уменьшает риск фиброзирования.\u003Cbr\u003EОказывает холеретическое действие.\u003Cbr\u003EАдеметионин нормализует синтез эндогенного фосфатидилхолина в гепатоцитах, что повышает текучесть и поляризацию мембран. Это улучшает функцию ассоциированных с мембранами гепатоцитов транспортных систем желчных кислот и способствует пассажу желчных кислот в желчевыводящие пути. Эффективен при внутридольковом варианте холестаза (нарушение синтеза и тока желчи). Адеметионин снижает токсичность желчных кислот в гепатоците, осуществляя их конъюгирование и сульфатирование. Конъюгация с таурином повышает растворимость желчных кислот и выведение их из гепатоцита. Процесс сульфатирования желчных кислот способствует возможности их элиминации почками, облегчает прохождение через мембрану гепатоцита и выведение с желчью. Кроме этого, сами сульфатированные желчные кислоты дополнительно защищают мембраны клеток печени от токсического действия несульфатированных желчных кислот (в высоких концентрациях присутствующих в гепатоцитах при внутрипеченочном холестазе).\u003Cbr\u003EУ пациентов с диффузными заболеваниями печени (цирроз, гепатит) с синдромом внутрипеченочного холестаза адеметионин снижает выраженность кожного зуда и изменений биохимических показателей, в т.ч. концентрации прямого билирубина, активности щелочной фосфатазы, аминотрансфераз и др.\u003Cbr\u003EХолеретический и гепатопротективный эффект сохраняется до 3 месяцев после прекращения лечения.\u003Cbr\u003EПоказана эффективность при гепатопатиях, обусловленных различными гепатотоксичными препаратами.\u003Cbr\u003EАнтидепрессивная активность проявляется постепенно, начиная с конца первой недели лечения, и стабилизируется в течение 2 недель лечения.\u003Cbr\u003EВ ряде исследований была подтверждена эффективность адеметионина при лечении повышенной утомляемости у пациентов с хроническими заболеваниями печени. Объединенный анализ данных, полученный у пациентов с наличием симптомов повышенной утомляемости до начала лечения, доказал эффект лечения адеметионином в отношении уменьшения симптомов повышенной утомляемости в сочетании с рядом других симптомов, таких как депрессия, иктеричность кожных покровов и слизистых, недомогание и кожный зуд.\u003Cbr\u003EЛечение адеметионином достоверно улучшало настроение у пациентов с алкогольной болезнью печени, у которых одновременно был достигнут положительный ответ со стороны симптомов повышенной утомляемости. Кроме того, у пациентов с алкогольной болезнью печени и неалкогольной жировой болезнью печени с достигнутым ответом на лечение адеметионином со стороны симптомов повышенной утомляемости также наблюдалось достоверное ослабление таких симптомов, как иктеричность кожных покровов и слизистых, недомогание и кожный зуд."},{"name":"Фармакологическая группа","value":"прочие препараты для желудочно-кишечного тракта и обмена веществ, аминокислоты и их производные"},{"name":"Форма выпуска","value":"таблетки, покрытые кишечнорастворимой оболочкой"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"В защищенном от света месте, при температуре от 15 °С до 25 °С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Передозировка препарата Гептрал маловероятна. В случае передозировки рекомендуется наблюдение за пациентом и проведение симптоматической терапии."},{"name":"Применение при беременности и кормлении грудью","value":"В клинических исследованиях было показано, что применение адеметионина в III триместре беременности не вызывало никаких нежелательных эффектов.\u003Cbr\u003EПрименение препарата Гептрал у беременных в I триместре и в период грудного вскармливания возможно, только если потенциальная польза для матери превышает возможный риск для плода или ребенка."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"У некоторых пациентов при приеме препарата Гептрал может возникнуть головокружение. Не рекомендуется водить автомобиль и работать с механизмами во время приема препарата до тех пор, пока у пациента не возникнет уверенность, что терапия не влияет на способность заниматься подобного вида деятельностью."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EБеременность (I триместр) и период грудного вскармливания (применение возможно, только если потенциальная польза для матери превышает возможный риск для плода или ребенка).\u003Cbr\u003EОдновременный прием с селективными ингибиторами обратного захвата серотонина (СИОЗС), трициклическими антидепрессантами (такими как кломипрамин), а также препаратами растительного происхождения и препаратами, содержащими триптофан (см. раздел \"Взаимодействие с другими лекарственными препаратами\").\u003Cbr\u003EПожилой возраст.\u003Cbr\u003EПочечная недостаточность.\u003Cbr\u003EУчитывая тонизирующий эффект препарата, не рекомендуется принимать его перед сном.\u003Cbr\u003EПри применении препарата Гептрал пациентами с циррозом печени на фоне гиперазотемии необходим систематический контроль содержания азота в крови. Во время длительной терапии необходимо определять содержание мочевины и креатинина в сыворотке крови.\u003Cbr\u003EЕсть сообщения о переходе депрессии в гипоманию или манию у пациентов, принимавших адеметионин.\u003Cbr\u003EУ пациентов с депрессией имеется повышенный риск суицида и других серьезных нежелательных явлений, поэтому во время лечения адеметионином такие пациенты должны находиться под постоянным наблюдением врача для оценки и лечения симптомов депрессии. Пациенты должны информировать врача в случае, если отмечающиеся у них симптомы депрессии не уменьшаются или усугубляются при терапии адеметионином. Также имеются сообщения о внезапном появлении или нарастании тревоги у пациентов, принимающих адеметионин. В большинстве случаев отмена терапии не требуется, в нескольких случаях тревога исчезала после снижения дозы или отмены препарата.\u003Cbr\u003EПоскольку дефицит цианокобаламина и фолиевой кислоты может снизить содержание адеметионина у пациентов группы риска (с анемией, заболеваниями печени, при беременности или вероятностью витаминной недостаточности, в связи с другими заболеваниями или диетой, например, у вегетарианцев), следует контролировать содержание витаминов в плазме крови. Если недостаточность обнаружена, рекомендован прием цианокобаламина и фолиевой кислоты до начала лечения адеметионином или одновременный прием с адеметионином.\u003Cbr\u003EПри иммунологическом анализе применение адеметионина может способствовать ложному определению показателя высокого содержания гомоцистеина в крови.\u003Cbr\u003EДля пациентов, принимающих адеметионин, рекомендовано использовать неиммунологические методы анализа для определения содержания гомоцистеина."},{"name":"Взаимодействие","value":"Известных взаимодействий с другими лекарственными средствами не наблюдалось. Есть сообщение о синдроме избытка серотонина у пациента, принимавшего адеметионин и кломипрамин. Считается, что такое взаимодействие возможно, и следует с осторожностью назначать адеметионин вместе с селективными ингибиторами обратного захвата серотонина, трициклическими антидепрессантами (такими как кломипрамин), а также травами и препаратами, содержащими триптофан."},{"name":"Регистрационный номер","value":"П N011968/01"},{"name":"Дата государственной регистрации","value":"26.03.2018"},{"name":"Владелец регистрационного удостоверения","value":"Abbott Laboratories GmbH","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["34324371:35649313","7893318:16228944"]}}},{"name":"Изготовитель","value":"AbbVie"},{"name":"Фасовщик","value":"AbbVie"},{"name":"Страна бренда","value":"Германия"},{"name":"Страна-производитель","value":"Италия"},{"name":"Название препарата","value":"Гептрал","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["17796364:18008564"]}}},{"name":"Срок годности","value":"35 мес."}]}},"fullSpecsGrouped":{"17817890755682836080":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Органы и системы","value":"печень, пищеварительная система"},{"name":"Назначение","value":"внутрипеченочный холестаз, депрессия, невирусный гепатит, острые гепатиты, токсические поражения печени, холангит, холецистит, хронические воспалительные заболевания печени, цирроз печени, энцефалопатия"},{"name":"Показания к применению","value":"- Внутрипеченочный холестаз при прецирротических и цирротических состояниях, который может наблюдаться при следующих заболеваниях:\u003Cbr\u003E- жировая дистрофия печени;\u003Cbr\u003E- хронический гепатит;\u003Cbr\u003E- токсические поражения печени различной этиологии, включая алкогольные, вирусные, лекарственные (антибиотики; противоопухолевые, противотуберкулезные и противовирусные препараты, трициклические антидепрессанты, пероральные контрацептивы);\u003Cbr\u003E- хронический бескаменный холецистит;\u003Cbr\u003E- холангит;\u003Cbr\u003E- цирроз печени;\u003Cbr\u003E- энцефалопатия, в т.ч. ассоциированная с печеночной недостаточностью (алкогольная и др.).\u003Cbr\u003E- Внутрипеченочный холестаз у беременных.\u003Cbr\u003E- Симптомы депрессии.\u003Cbr\u003E- Повышенная утомляемость при хронических заболеваниях печени."},{"name":"Противопоказания","value":"Генетические нарушения, влияющие на метиониновый цикл, и/или вызывающие гомоцистинурию и/или гипергомоцистеинемию (дефицит цистатионин бетасинтазы, нарушение метаболизма витамина В12).\u003Cbr\u003EГиперчувствительность к любому из компонентов препарата.\u003Cbr\u003EВозраст до 18 лет (опыт медицинского применения у детей ограничен).\u003Cbr\u003EБиполярные расстройства."},{"name":"Состав","value":"Каждая таблетка содержит:\u003Cbr\u003EДействующее вещество: адеметионина 1,4-бутандисульфонат 760 мг (соответствует 400 мг иона адеметионина).\u003Cbr\u003EВспомогательные вещества: кремния диоксид коллоидный - 4,4 мг, целлюлоза микрокристаллическая - 93,6 мг, карбоксиметилкрахмал натрия (тип А) - 17,6 мг, магния стеарат - 4,4 мг;\u003Cbr\u003Eоболочка таблетки: метакриловой кислоты и этилакрилата сополимер (1:1) - 27,6 мг, макрогол-6000 - 8,07 мг, полисорбат-80 - 0,44 мг, симетикон (эмульсия 30%) - 0,13 мг, натрия гидроксид - 0,36 мг, тальк - 18,4 мг, вода - Q.S."},{"name":"Действующее вещество","value":"Адеметионин"},{"name":"Способ применения и дозы","value":"Внутрь. Таблетки следует принимать целиком, не разжевывая, желательно в первой половине дня между приемами пищи.\u003Cbr\u003EТаблетки препарата Гептрал следует вынимать из блистера непосредственно перед приемом внутрь. В случае, если таблетки имеют цвет, отличный от белого до белого с желтоватым оттенком (вследствие негерметичности алюминиевой фольги), препарат Гептрал использовать не рекомендуется.\u003Cbr\u003EНачальная терапия\u003Cbr\u003EРекомендуемая доза составляет 10-25 мг/кг/сут внутрь.\u003Cbr\u003EВнутрипеченочный холестаз повышенная утомляемость при хронических заболеваниях печени\u003Cbr\u003EДоза составляет от 800 мг/сут до 1600 мг/сут.\u003Cbr\u003EДепрессия\u003Cbr\u003EДоза составляет от 800 мг/сут до 1600 мг/сут.\u003Cbr\u003EДлительность терапии определяется врачом.\u003Cbr\u003EТерапия препаратом Гептрал может быть начата с внутривенного или внутримышечного введения с последующим применением препарата Гептрал в виде таблеток или сразу с применения препарата Гептрал в виде таблеток.\u003Cbr\u003EПациенты пожилого возраста\u003Cbr\u003EКлинический опыт применения препарата Гептрал не выявил каких-либо различий в его эффективности у пациентов пожилого возраста и пациентов более молодого возраста. Однако, учитывая высокую вероятность имеющихся нарушений функции печени, почек или сердца, другой сопутствующей патологии или одновременной терапии с другими лекарственными средствами, дозу препарата Гептрал пожилым пациентам следует подбирать с осторожностью, начиная применение препарата с нижнего предела диапазона доз.\u003Cbr\u003EПочечная недостаточность\u003Cbr\u003EИмеются ограниченные клинические данные о применении препарата Гептрал у пациентов с почечной недостаточностью, в связи с этим рекомендуется соблюдать осторожность при применении препарата Гептрал у таких пациентов.\u003Cbr\u003EПеченочная недостаточность\u003Cbr\u003EПараметры фармакокинетики адеметионина сходны у здоровых добровольцев и у пациентов с хроническими заболеваниями печени.\u003Cbr\u003EДети\u003Cbr\u003EПрименение препарата Гептрал у детей противопоказано (эффективность и безопасность не установлены)."},{"name":"Побочные действия","value":"Со стороны пищеварительной системы: часто - тошнота, боли в животе, диарея; редко - рвота, сухость во рту, эзофагит, диспепсия, метеоризм, желудочно-кишечная боль, желудочно-кишечное кровотечение, печеночная колика.\u003Cbr\u003EСо стороны нервной системы: редко - спутанность сознания, бессонница, головокружение, головная боль, парестезии.\u003Cbr\u003EСо стороны костно-мышечной системы: редко - артралгии, мышечные судороги.\u003Cbr\u003EСо стороны мочевыделительной системы: редко - инфекции мочевыводящих путей.\u003Cbr\u003EСо стороны кожных покровов: редко - гипергидроз, зуд, кожная сыпь.\u003Cbr\u003EМестные реакции: редко - реакции в месте введения; очень редко - реакции в месте введения, некроз кожи в месте введения.\u003Cbr\u003EАллергические реакции: редко - анафилактические реакции; очень редко - отек Квинке, отек гортани.\u003Cbr\u003EПрочие: редко - приливы, поверхностный флебит, астения, озноб, гриппоподобные симптомы, слабость, периферические отеки, гипертермия."},{"name":"Фармакологическое действие","value":"Адеметионин относится к группе гепатопротекторов, обладает также антидепрессивной активностью.\u003Cbr\u003EОказывает холеретическое и холекинетическое действие, обладает детоксикационными, регенерирующими, антиоксидантными, антифиброзирующими и нейропротективными свойствами.\u003Cbr\u003EВосполняет дефицит S-аденозил-L-метионина (адеметионина) и стимулирует его выработку в организме, содержится во всех средах организма. Наибольшая концентрация адеметионина отмечена в печени и мозге.\u003Cbr\u003EВыполняет ключевую роль в метаболических процессах организма, принимает участие в важных биохимических реакциях: трансметилировании, транссульфурировании, трансаминировании. В реакциях трансметилирования адеметионин донирует метальную группу для синтеза фосфолипидов клеточных мембран, нейротрансмиттеров, нуклеиновых кислот, белков, гормонов и др. В реакциях транссульфурирования адеметионин является предшественником цистеина, таурина, глютатиона (обеспечивая окислительно-восстановительный механизм клеточной детоксикации), коэнзима А (включается в биохимические реакции цикла трикарбоновых кислот и восполняет энергетический потенциал клетки).\u003Cbr\u003EПовышает содержание глутамина в печени, цистеина и таурина в плазме; снижает содержание метионина в сыворотке, нормализуя метаболические реакции в печени. После декарбоксилирования участвует в реакциях аминопропилирования, как предшественник полиаминов путресцина (стимулятор регенерации клеток и пролиферации гепатоцитов), спермидина и спермина, входящих в структуру рибосом, что уменьшает риск фиброзирования.\u003Cbr\u003EОказывает холеретическое действие.\u003Cbr\u003EАдеметионин нормализует синтез эндогенного фосфатидилхолина в гепатоцитах, что повышает текучесть и поляризацию мембран. Это улучшает функцию ассоциированных с мембранами гепатоцитов транспортных систем желчных кислот и способствует пассажу желчных кислот в желчевыводящие пути. Эффективен при внутридольковом варианте холестаза (нарушение синтеза и тока желчи). Адеметионин снижает токсичность желчных кислот в гепатоците, осуществляя их конъюгирование и сульфатирование. Конъюгация с таурином повышает растворимость желчных кислот и выведение их из гепатоцита. Процесс сульфатирования желчных кислот способствует возможности их элиминации почками, облегчает прохождение через мембрану гепатоцита и выведение с желчью. Кроме этого, сами сульфатированные желчные кислоты дополнительно защищают мембраны клеток печени от токсического действия несульфатированных желчных кислот (в высоких концентрациях присутствующих в гепатоцитах при внутрипеченочном холестазе).\u003Cbr\u003EУ пациентов с диффузными заболеваниями печени (цирроз, гепатит) с синдромом внутрипеченочного холестаза адеметионин снижает выраженность кожного зуда и изменений биохимических показателей, в т.ч. концентрации прямого билирубина, активности щелочной фосфатазы, аминотрансфераз и др.\u003Cbr\u003EХолеретический и гепатопротективный эффект сохраняется до 3 месяцев после прекращения лечения.\u003Cbr\u003EПоказана эффективность при гепатопатиях, обусловленных различными гепатотоксичными препаратами.\u003Cbr\u003EАнтидепрессивная активность проявляется постепенно, начиная с конца первой недели лечения, и стабилизируется в течение 2 недель лечения.\u003Cbr\u003EВ ряде исследований была подтверждена эффективность адеметионина при лечении повышенной утомляемости у пациентов с хроническими заболеваниями печени. Объединенный анализ данных, полученный у пациентов с наличием симптомов повышенной утомляемости до начала лечения, доказал эффект лечения адеметионином в отношении уменьшения симптомов повышенной утомляемости в сочетании с рядом других симптомов, таких как депрессия, иктеричность кожных покровов и слизистых, недомогание и кожный зуд.\u003Cbr\u003EЛечение адеметионином достоверно улучшало настроение у пациентов с алкогольной болезнью печени, у которых одновременно был достигнут положительный ответ со стороны симптомов повышенной утомляемости. Кроме того, у пациентов с алкогольной болезнью печени и неалкогольной жировой болезнью печени с достигнутым ответом на лечение адеметионином со стороны симптомов повышенной утомляемости также наблюдалось достоверное ослабление таких симптомов, как иктеричность кожных покровов и слизистых, недомогание и кожный зуд."},{"name":"Фармакологическая группа","value":"прочие препараты для желудочно-кишечного тракта и обмена веществ, аминокислоты и их производные"},{"name":"Форма выпуска","value":"таблетки, покрытые кишечнорастворимой оболочкой"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"В защищенном от света месте, при температуре от 15 °С до 25 °С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Передозировка препарата Гептрал маловероятна. В случае передозировки рекомендуется наблюдение за пациентом и проведение симптоматической терапии."},{"name":"Применение при беременности и кормлении грудью","value":"В клинических исследованиях было показано, что применение адеметионина в III триместре беременности не вызывало никаких нежелательных эффектов.\u003Cbr\u003EПрименение препарата Гептрал у беременных в I триместре и в период грудного вскармливания возможно, только если потенциальная польза для матери превышает возможный риск для плода или ребенка."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"У некоторых пациентов при приеме препарата Гептрал может возникнуть головокружение. Не рекомендуется водить автомобиль и работать с механизмами во время приема препарата до тех пор, пока у пациента не возникнет уверенность, что терапия не влияет на способность заниматься подобного вида деятельностью."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EБеременность (I триместр) и период грудного вскармливания (применение возможно, только если потенциальная польза для матери превышает возможный риск для плода или ребенка).\u003Cbr\u003EОдновременный прием с селективными ингибиторами обратного захвата серотонина (СИОЗС), трициклическими антидепрессантами (такими как кломипрамин), а также препаратами растительного происхождения и препаратами, содержащими триптофан (см. раздел \"Взаимодействие с другими лекарственными препаратами\").\u003Cbr\u003EПожилой возраст.\u003Cbr\u003EПочечная недостаточность.\u003Cbr\u003EУчитывая тонизирующий эффект препарата, не рекомендуется принимать его перед сном.\u003Cbr\u003EПри применении препарата Гептрал пациентами с циррозом печени на фоне гиперазотемии необходим систематический контроль содержания азота в крови. Во время длительной терапии необходимо определять содержание мочевины и креатинина в сыворотке крови.\u003Cbr\u003EЕсть сообщения о переходе депрессии в гипоманию или манию у пациентов, принимавших адеметионин.\u003Cbr\u003EУ пациентов с депрессией имеется повышенный риск суицида и других серьезных нежелательных явлений, поэтому во время лечения адеметионином такие пациенты должны находиться под постоянным наблюдением врача для оценки и лечения симптомов депрессии. Пациенты должны информировать врача в случае, если отмечающиеся у них симптомы депрессии не уменьшаются или усугубляются при терапии адеметионином. Также имеются сообщения о внезапном появлении или нарастании тревоги у пациентов, принимающих адеметионин. В большинстве случаев отмена терапии не требуется, в нескольких случаях тревога исчезала после снижения дозы или отмены препарата.\u003Cbr\u003EПоскольку дефицит цианокобаламина и фолиевой кислоты может снизить содержание адеметионина у пациентов группы риска (с анемией, заболеваниями печени, при беременности или вероятностью витаминной недостаточности, в связи с другими заболеваниями или диетой, например, у вегетарианцев), следует контролировать содержание витаминов в плазме крови. Если недостаточность обнаружена, рекомендован прием цианокобаламина и фолиевой кислоты до начала лечения адеметионином или одновременный прием с адеметионином.\u003Cbr\u003EПри иммунологическом анализе применение адеметионина может способствовать ложному определению показателя высокого содержания гомоцистеина в крови.\u003Cbr\u003EДля пациентов, принимающих адеметионин, рекомендовано использовать неиммунологические методы анализа для определения содержания гомоцистеина."},{"name":"Взаимодействие","value":"Известных взаимодействий с другими лекарственными средствами не наблюдалось. Есть сообщение о синдроме избытка серотонина у пациента, принимавшего адеметионин и кломипрамин. Считается, что такое взаимодействие возможно, и следует с осторожностью назначать адеметионин вместе с селективными ингибиторами обратного захвата серотонина, трициклическими антидепрессантами (такими как кломипрамин), а также травами и препаратами, содержащими триптофан."},{"name":"Регистрационный номер","value":"П N011968/01"},{"name":"Дата государственной регистрации","value":"26.03.2018"},{"name":"Владелец регистрационного удостоверения","value":"Abbott Laboratories GmbH"},{"name":"Изготовитель","value":"AbbVie"},{"name":"Фасовщик","value":"AbbVie"},{"name":"Страна бренда","value":"Германия"},{"name":"Страна-производитель","value":"Италия"},{"name":"Название препарата","value":"Гептрал"},{"name":"Срок годности","value":"35 мес."}]}],"transitionId":"tr_3630836135768027890"}}}}
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Цена с картой Яндекс Пэй:2 002 ₽

Скидка: 16%
–16 %
Вместо: 2 022 ₽2 386 ₽
  • Сегодня, курьер магазина • 99 ₽
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  • Эссенциале форте Н капс., 300 мг, 30 шт.
    –1 %
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    Эссенциале форте Н капс., 300 мг, 30 шт.

    Рейтинг товара: 4.9 из 5
    на основе 247 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 751 ₽ вместо 759
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  • Гептор таб. п/о кш/раств., 400 мг, 20 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-up7qko2nb3j/toggleWishlist":{"skuId":"228041336","productId":1400799573,"offerId":"XQkr_Bi3OPZ2uYQcrSXyLQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ8suV3IrZhYNIEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI1YL6mwUQ+MTebBja1KEFINrZwQc=","sign":"f83SNWHiqK3kagW0h1hJMkYtOc/Gg8MvZ/zFphNYP/4="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-up7qko2nb3j/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Гептор таб. п/о кш/раств., 400 мг, 20 шт.

    Рейтинг товара: 5 из 5
    на основе 45 оценок
    Цена 1 234 ₽
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-up7qko2nb3j/addToCartButton":{"offerId":"XQkr_Bi3OPZ2uYQcrSXyLQ","skuId":"228041336","pendingCartItem":{"productId":1400799573,"offerId":"XQkr_Bi3OPZ2uYQcrSXyLQ","showPlaceId":"OTNDnItfwRMjN9MRHuEMMlXI1nKtP1fjEtJ70YJEulVaFGOhfVoy3KblkZRs4dDs3j-Rrwu2BMuQcw8koNsLdwNJb3c648DomEhwvnQAnPeM9GXG-beb9cTi47ipS0zTzH-cKTOf_BkQ3TISUmIGUbjB8UNTk2oHKAs-9M9evbGqAFcjxjoLKYKq033KU2KC1pYUh7BXzX5I-X-vO1BQkg,,","feeShow":"OTNDnItfwRMjN9MRHuEMMlXI1nKtP1fjEtJ70YJEulVaFGOhfVoy3KblkZRs4dDs3j-Rrwu2BMuQcw8koNsLdwNJb3c648DomEhwvnQAnPeM9GXG-beb9cTi47ipS0zTzH-cKTOf_BkQ3TISUmIGUbjB8UNTk2oHKAs-9M9evbGqAFcjxjoLKYKq033KU2KC1pYUh7BXzX5I-X-vO1BQkg,,","skuId":"228041336","shopId":55106433,"price":{"applicablePriceDiscounts":[],"value":"1234","currency":"RUR"},"hid":"15756506","name":"Гептор таб. п/о кш/раств., 400 мг, 20 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  • Гептрал лиоф. д/приг. р-ра для в/в и в/м введ. фл. р-ль амп., 400 мг, 5 шт.
    –12 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-5t797y14cqf/toggleWishlist":{"skuId":"227812453","productId":1780857191,"offerId":"qS0TTIQo4XNiaItYuMQs2g","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ8suV3IrZhYNIEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI5/KW0QYQ5cjQbBjQxN4HINrZwQc=","sign":"Lj0htqCK2Bujd0l5z4v9ZD12MoyEe/L1EhlehzqvsRk="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-5t797y14cqf/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Гептрал лиоф. д/приг. р-ра для в/в и в/м введ. фл. р-ль амп., 400 мг, 5 шт.

    Рейтинг товара: 5 из 5
    на основе 52 оценки
    Цена 1 937 ₽ вместо 2 208
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  • Адеметионин таб. кш/раств., 400 мг, 40 шт.
    –2 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-7qx727t610r/toggleWishlist":{"skuId":"102038996038","productId":1756207383,"offerId":"3gW1rDfncD9qvgaXXjdTSA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ8suV3IrZhYNIEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIl7K2xQYQxoj+j/wCGKev2Acg2tnBBw==","sign":"4SZI4MP+6hAuJCKsxLLUD203msMzgtHkCMYFKbAiOSY="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-7qx727t610r/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Адеметионин таб. кш/раств., 400 мг, 40 шт.

    Рейтинг товара: 4.4 из 5
    на основе 8 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 2 858 ₽ вместо 2 916
    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таб. кш/раств., 400 мг, 40 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  • Гептрал таб. п/о кш/раств., 500 мг, 20 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-8ive6vb55uk/toggleWishlist":{"skuId":"101454441770","productId":228007633,"offerId":"x9UhAYA5RuPGZmTa01dU7g","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ8suV3IrZhYNIEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYI0b3cbBCq2p/5+QIY0MTeByDa2cEH","sign":"4+U+vEyhLRKUEsdan7ncXjqNBflhN8fVR3RmWi5HFu8="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-8ive6vb55uk/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Гептрал таб. п/о кш/раств., 500 мг, 20 шт.

    Рейтинг товара: 5 из 5
    на основе 8 оценок
    Цена 2 433 ₽
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-8ive6vb55uk/addToCartButton":{"offerId":"x9UhAYA5RuPGZmTa01dU7g","skuId":"101454441770","pendingCartItem":{"productId":228007633,"offerId":"x9UhAYA5RuPGZmTa01dU7g","showPlaceId":"OTNDnItfwRMjN9MRHuEMMlXI1nKtP1fjFQFMNi4ucqSr_nG8--lRxIgfWj2sLMZYUDGdynkfGO6iV_t8D2akl8skSDRQ0xTkcyWTT7uaLbbxhB8Mz85uubvfrlP2EBQ_UDhkrCeldK4U4rt_gPTFBxrzDtw87St9PEhtJpA01Cq-yfmzeB7WDiAVG4ORyXN6XKUBJVoXEhdmhawVcZLiCw,,","feeShow":"OTNDnItfwRMjN9MRHuEMMlXI1nKtP1fjFQFMNi4ucqSr_nG8--lRxIgfWj2sLMZYUDGdynkfGO6iV_t8D2akl8skSDRQ0xTkcyWTT7uaLbbxhB8Mz85uubvfrlP2EBQ_UDhkrCeldK4U4rt_gPTFBxrzDtw87St9PEhtJpA01Cq-yfmzeB7WDiAVG4ORyXN6XKUBJVoXEhdmhawVcZLiCw,,","skuId":"101454441770","shopId":55106433,"price":{"applicablePriceDiscounts":[],"value":"2433","currency":"RUR"},"hid":"15756506","name":"Гептрал таб. п/о кш/раств., 500 мг, 20 шт.","label":"mxwcirjk9ms","count":0,"features":[],"imageMeta":{"namespace":"mpic","groupId":5290046,"key":"img_id9003769502032887702.jpeg"}},"quantity":{"step":1,"minimum":1,"maximum":999},"cpaUrl":"/safeclick/data=TxNGOK9vJEN7oLFLeCTKEixJYuEMI0EzvZFs82AjjgjhTwweZ7mRXd_AQ0K184sfZmy5nQz7U8xIc-qdVOMFoxnoSww2ObzLEs1KJpltGipDSanCui6QCo8GXRHxAQaqQQZbzp5kb0bdQDXqQiIIDEwL4INEBUjrbUNtjxqZ96WFVmZtSFtMyb3yJJ0vvI_f_VoLwr8_fQDSzGtzWieo587A01A4gdT9nY4pLCad0TKC0Sg7u5oPerKVjD9r9stuum9dxCxIniToGuw2_I2eVD3s0VtYQwa43hC05mtiH3sYxrDf4u0U9em0cTZYp9fu3zAWPeY4JIcE13r_lU67AESBmNgL6zYTzpYZyIVjWA2DAgJJDH82O9h504kgZ0q-5qil4ZRsiu0NnLuRGBdTpTRaHpF5CsFXPH05J1ee2NeSFX5dKXDxIn0c9vuEFapXZwRSmWTQRXcZDUqqQqEfpA97p8e1THZIdy0mjGCXL-bjpYBjZRRS54MsEjm5QS0cOHf4sOZAyjbeL5r4BrqXsLz0mqjYHvBOBu1zaMZsUnN_NrsjLQsUULKwNcQWfSf1o0AcrlS9t33XOzx5Qe1vTaqIF6h-bUDgTYpd0HW_8OX6EDq5fc8FsJW5TlZSyrWvSt74ju4WYYDdGEEcJ6Rf8MGSqTGOw43CtC17UqaWTQ9xNxmwfReHcHfHrqj1-f5zTh1Xtjt5l1qL7a96qkrhaRCkT0nIyKR6i59PONBYyLC4rWnZDm9q0cXTyclwKY7py25fznzcl42uZelK1Hobz1-XTxJy3Dic_chTBq0e9xNelZL5xRbOn3jzHE0g3FoqgHyA_2ixHTV80msBHSFArp1j4rKnXojL_YbQBHXxIuTslMgBLMoQrnQ6cEeKXamC1wKLit0_OZWOnPZTrPCTf0wI-KqjAJjTv8Lc08rvZYBmcyBz7vi9tEnJHb3xd-hYt-9o8YynoEKEtQvnNZpSS-pmeCZSzwYE9DUzp8Ud9JZDaJ6KupJTE8z7pmzcCUVyumcq2oImMTl5Zogv1kVMG1IQfNSFZx7pXUAyG4yppHFnETGthgtthOe5Zx08ihi9Gp_RUCAjizudq2_ox8ntVaUkmp7EG0FBTAO-fsuKsWF9Q4Mka2loF1YLiQgTwLFjF7G_Tj3tUAwolgtV-9gltrV6KY1uaM504COIiK8E6K0LQx-o2_itkUUejCcPvpSy1UYKJXropsHGotjp9PPkbPqSnsb9F3XEu8zYDnJQKPB2Rrb_FcGIrqc5eqvMNWXek8G-H5xrHkdfH4L7BaRW20BIIHXbbpmjnmobMiGtlRw30lguXctxwPTCXOb27dKhlz2oUZCOJN7BBpJaRcWEzCGMAJJKKDndYpm3Cs3mjXZw5usQsoJpZb624IhkvB7WJsmo7Ft7K_GQwf-bQPoN0GKZ7aFxWSTx0T8U_gUfmW4SE_10tbRlU6uCCi9UWcZKSrst0EtV7ADOlLscZ7eSbi_58SrKnnT37vi7N0_fMD2sPcQOeREN8h8cxwaTtV91TpKSO0PQ1LN6ivT_tB9lBAexEnkdhw0RsF_oc5kdY8YHzlExsBjCrdjL2hi9fbU1nlIQZah0aKNLJtdOxAtciTlnKaWJzoVOkIoKXI2l-nd4nYJLAaoe_3y2QATL1xOPRgyH6TD5x5dPiB2YCkzxRI7rsAqpI45w05wSjKNQ7LuV0-2VFVTqqT8RWHssv6uRh7r22cuoB5vk3Y6-Isi7Ztn6sP_c45OwU-SDWn--mONVYgEynDEr_YIOkoLaPP4eBC8A78xk_2qhPl_UdgjR2Ez2J7M3WgKourmVv0FVyZVraAwvjepV6WeWW0n6mzVsxz0vG07FnCoKrp2icdg1G0xwbK_TsH4fddpa6uwP_7N6hnpU26Et4IAY41QYV3e5TWCjzne2oi7keKrEdrrTpmSFsTEJMvYE_Qo2at6N8N5UOieSdScaogncmgZVthtV_FNtsY40Ya3bN41WWiTG1KoW4DRHpXcLhQidqfNV-FVSREJH7NNqDavKI9joUtRx17LaLZ6fz5o0Ci18PcqxX2vWC5HJuBXq4qjiE5llgUmxrrZEYp_LF0IJjT4U0sMrypxIW4wZENPWwR-e0WqEywjIxvz40Ov7pXRZCQ7f610oFW4GJG5KlkBvYKVqzdqXJK7yUeHeroEPECICNKsSOQNiK96BDM8mQJboFx-Vk-VeOl79gCILp68Dscf-AnuOilzGMlnO_-kYFtE3TOvQl6m-l3pkeiAabAjKCCprQlFKYk_tO03HWH5HbjCQZubOcbdHZsICrABimIg8a0s2bd5ANfL-7MBDMsrv-1-49GIa_KxdM2dWwIAmn2oGOQAXKAGR5U60Ahd2j6aRGECu05sTNJ8dPFyHsrQdUWSnAAeywfri2ZRfUfHxOVNh8JG30z8A7aMZzUPDLyscAJRH0XiwC6zH2LihNXR1UtskypHEc1F-Rgmv9pYn1vUdG0zU7McfelF3v2_wzMTR4FMlRIKXuaD9XxNN3vc8ISlkeCK6lLGIBingCNhxtG6tzohEsztMZOxqMt3qPXBj2OYd_lQmB8bkTDCtjud4ki08Mof4KvTmnauOb-QLa-6UlBhQuNYeUuuvyUdbqHRQx-lJZOoaRZg3pHs2f4aj49AQVSugAhwH0aOBl15T3AwkmsWLt8akdf7OQwPOqql2YFmmIN0t9cH9tZ41JqhIsJU71-KHqaI8tLRGP_U0L9ehsjwEucD7pJbKPvadSnFKH5gr63bZlLNPygdysSYIoyPXMcauHKjD060XAGBZKzHPK9J2OBUuETJznXMeT5k_GVdorKktIe6_GdWXZ0nQdVM-l_c1mmVv4NHvXmGDkU5aBxzjb_y6H61g9bA8pNMluzb-F4qsHs7JXGRmQcn-mpZCE9fa-NMnh4868iW8OqN9ZwrsYyetuqPJcVSt4S8LInQI5UUq-rpVdHpfrsnDDkTX9hnBq1ubCCXU84FI2ycyEJ9-HPNyQcojT05Jv9n3SHEAekb98gTVibdTkFS-ITgd9joNFLl2SbNX8YCGxWtXWk306QEXFFFv06da66g655GboPjVvGD5hMenvEkrhAzSVv5Sax8ybmXRaRvtMZ0cYf4qyd5ulxZV7K3juQH6tg1jHTJgcwn8hV8VTNo9LEQ9nDTSz2Va2C27rW93hGtgLY2xw0Igd8QSRfW8VgfkKfhCmdFa8rAurugPug9XXpqrffpAN-QQLxgZXvps-4YchlLUK0Oo7c9u0Gtfq230jXuP3KUs_7m57XH97GqtQcs7JbKX3Wihcks0ZdQd4KbMFA-SK5GsILJPmuQE8vb-DzTK1XyEWDH-zWPM-9uGVV85gr_aI3shMXULzWcKCrxaaTDJKnM9s2lMZK8,/b64e=1/sign=767af27ca494aace5216ce6dbcbdb3d3/keyno=MARKET_1/*","showUid":"17179919233112464929106006","cartLink":"/my/cart","showNotificationWhenDeleteItem":true,"isLavka":false,"isError":false,"isEats":false,"isCR":false,"isM2bEdoOnlyEnable":false,"isEatsMarketIntegration":true,"isCartButtonNext":false,"isUpsalePopupCRExp":false,"baobabClientDataAdditionToCart":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ8suV3IrZhYNIEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYI0b3cbBCq2p/5+QIY0MTeByDa2cEH","sign":"4+U+vEyhLRKUEsdan7ncXjqNBflhN8fVR3RmWi5HFu8="},"target":"cart_addition"},"baobabClientDataDeletionFromCart":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ8suV3IrZhYNIEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYI0b3cbBCq2p/5+QIY0MTeByDa2cEH","sign":"4+U+vEyhLRKUEsdan7ncXjqNBflhN8fVR3RmWi5HFu8="},"target":"cart_deletion"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-8ive6vb55uk/addToCartButton":{"name":"@light/AddToCartButtonSnippet"}}}
  • Гептрал лиоф. для приг. р-ра для в/в и в/м введ. фл., 400 мг, 5 шт.
    –21 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-8lita3qfdda/toggleWishlist":{"skuId":"830543019","productId":1780857984,"offerId":"JZ-ZvjcVSJApfsnbi_FprQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ8suV3IrZhYNIEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIgPmW0QYQq6mEjAMY0MTeByDa2cEH","sign":"4Gd8YuxEXUyvUcHwrsbFtojy7G5QERoGYYVNL2X4K0s="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-8lita3qfdda/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Гептрал лиоф. для приг. р-ра для в/в и в/м введ. фл., 400 мг, 5 шт.

    Рейтинг товара: 5 из 5
    на основе 19 оценок
    Цена 1 990 ₽ вместо 2 518
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  • Гептрал таб. п/о плен., 500 мг, 20 шт.
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    Гептрал таб. п/о плен., 500 мг, 20 шт.

    Рейтинг товара: 4.9 из 5
    на основе 16 оценок
    Цена 2 439 ₽
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  • Самеликс таб. п/о плен. кш/раств., 400 мг, 20 шт.
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    Самеликс таб. п/о плен. кш/раств., 400 мг, 20 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 1 320 ₽
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  • Гептрал лиоф. д/приг. р-ра для в/в и в/м введ. фл. + р-ль в амп., 400 мг, 5 шт.
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    Гептрал лиоф. д/приг. р-ра для в/в и в/м введ. фл. + р-ль в амп., 400 мг, 5 шт.

    Рейтинг товара: 4.9 из 5
    на основе 55 оценок
    Цена 1 938 ₽
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  • Фосфоглив капс., 96 шт.
    –2 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-n1ibxfvfr5g/toggleWishlist":{"skuId":"993830135","productId":1778171876,"offerId":"HUpb2K3QKNGNNUyppr4sOA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ8suV3IrZhYNIEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYI5P/yzwYQ98ny2QMYj7zeByDa2cEH","sign":"G196QZaV6+3r3/jKurQKIrsmjPwrdQ+LdOdbL0tQJCQ="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-n1ibxfvfr5g/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Фосфоглив капс., 96 шт.

    Рейтинг товара: 5 из 5
    на основе 43 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 237 ₽ вместо 1 263
    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капс., 96 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  • Фосфоглив капс., 50 шт.
    –1 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-kwj1i1qzzci/toggleWishlist":{"skuId":"186847737","productId":1780856733,"offerId":"WTIVcWsu8ruwzOhVUI7CIw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ8suV3IrZhYNIEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIne+W0QYQ+aOMWRiPvN4HINrZwQc=","sign":"SBAW8KSQvLxVr//Fywa8aitEguGBfk4YVq1TkBb1txM="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-kwj1i1qzzci/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Фосфоглив капс., 50 шт.

    Рейтинг товара: 4.8 из 5
    на основе 67 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 644 ₽ вместо 651
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Инструкция

Показания к применению

- Внутрипеченочный холестаз при прецирротических и цирротических состояниях, который может наблюдаться при следующих заболеваниях:
- жировая дистрофия печени;
- хронический гепатит;
- токсические поражения печени различной этиологии, включая алкогольные, вирусные, лекарственные (антибиотики; противоопухолевые, противотуберкулезные и противовирусные препараты, трициклические антидепрессанты, пероральные контрацептивы);
- хронический бескаменный холецистит;
- холангит;
- цирроз печени;
- энцефалопатия, в т.ч. ассоциированная с печеночной недостаточностью (алкогольная и др.).
- Внутрипеченочный холестаз у беременных.
- Симптомы депрессии.
- Повышенная утомляемость при хронических заболеваниях печени.

Противопоказания

Генетические нарушения, влияющие на метиониновый цикл, и/или вызывающие гомоцистинурию и/или гипергомоцистеинемию (дефицит цистатионин бетасинтазы, нарушение метаболизма витамина В12).
Гиперчувствительность к любому из компонентов препарата.
Возраст до 18 лет (опыт медицинского применения у детей ограничен).
Биполярные расстройства.

Способ применения и дозы

Внутрь. Таблетки следует принимать целиком, не разжевывая, желательно в первой половине дня между приемами пищи.
Таблетки препарата Гептрал следует вынимать из блистера непосредственно перед приемом внутрь. В случае, если таблетки имеют цвет, отличный от белого до белого с желтоватым оттенком (вследствие негерметичности алюминиевой фольги), препарат Гептрал использовать не рекомендуется.
Начальная терапия
Рекомендуемая доза составляет 10-25 мг/кг/сут внутрь.
Внутрипеченочный холестаз повышенная утомляемость при хронических заболеваниях печени
Доза составляет от 800 мг/сут до 1600 мг/сут.
Депрессия
Доза составляет от 800 мг/сут до 1600 мг/сут.
Длительность терапии определяется врачом.
Терапия препаратом Гептрал может быть начата с внутривенного или внутримышечного введения с последующим применением препарата Гептрал в виде таблеток или сразу с применения препарата Гептрал в виде таблеток.
Пациенты пожилого возраста
Клинический опыт применения препарата Гептрал не выявил каких-либо различий в его эффективности у пациентов пожилого возраста и пациентов более молодого возраста. Однако, учитывая высокую вероятность имеющихся нарушений функции печени, почек или сердца, другой сопутствующей патологии или одновременной терапии с другими лекарственными средствами, дозу препарата Гептрал пожилым пациентам следует подбирать с осторожностью, начиная применение препарата с нижнего предела диапазона доз.
Почечная недостаточность
Имеются ограниченные клинические данные о применении препарата Гептрал у пациентов с почечной недостаточностью, в связи с этим рекомендуется соблюдать осторожность при применении препарата Гептрал у таких пациентов.
Печеночная недостаточность
Параметры фармакокинетики адеметионина сходны у здоровых добровольцев и у пациентов с хроническими заболеваниями печени.
Дети
Применение препарата Гептрал у детей противопоказано (эффективность и безопасность не установлены).
Полная инструкция
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Гептрал таб. п/о кш/раств.
Гептрал таб. п/о кш/раств., 400 мг, 20 шт.
4.9
(196)
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26 вопросов
Инструкция

Цена с картой Яндекс Пэй:2 002 ₽

Скидка: 16%
–16 %
Вместо: 2 022 ₽2 386 ₽
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4.9
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У продавца:196 оценок·27 отзывов
У всех продавцов:911 оценок·188 отзывов
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user avatar
4 месяца назад • Ir ir • Куплен на Маркете
Достоинства: после приёма 1й упаковки все печёночные показатели пришли в норму.
Недостатки: нет
Комментарий: берите это оригинальный препарат и очень эффективный, рекомендую, до него много лет алт показатель был сильно завышен, после недельного курса пришёл в норму, сдавала анализ через 2 недели и через 2 мес, результат держится
user avatar
9 месяцев назад • Светлана • Куплен на Маркете
Достоинства: Отличная волшебная конфета как говорит мой доктор. Для поддержания работы печени раз в полгода пропиваю курс. В качестве отличного эффекта действует как антидепрессант. У папы цирроз без Гептрала совсем было бы туго
Недостатки: Нет
Комментарий: По рекомендации врача стопроцентно да
user avatar
2 недели назад • Lev T. • Куплен на Маркете
Достоинства: Настоящий, проверил знаком качества
Недостатки: Не должны таблетки столько стоить, личное убеждение
Комментарий: Доставили в тот же день, точнее вечер, не смотря на позднее время
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