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Описание

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Тобрисс гл. капли фл.- капельница, 0.3%, 5 мл, 1 шт.

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У продавца: 
нет • На Маркете: 5.0
(7)
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Коротко о товаре

Артикул Маркета
3312265648
Тип препарата
Назначение
Действующее вещество
Возраст
от 2 месяцев
Инструкция
{"widgets":{"@card/SpecsList":{"/content/page/fancyPage/productSpecsList":{"wrapperProps":{"margins":{"top":4,"bottom":4}},"specsLimit":5,"title":"Коротко о товаре","titleSize":"14","type":"minimal","offset":"s","isHealthCategory":true,"forceShowWidget":true,"withFridge":true}}},"meta":{"/content/page/fancyPage/productSpecsList":{"name":"@card/SpecsList"}},"collections":{"minimalSpecs":{"17556188914587251306":{"specItems":[{"name":"Артикул Маркета","value":"3312265648","withCopyValueButton":true},{"name":"тип препарата","value":"рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"назначение","value":"бактериальные инфекции глаз","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["36476390:36617693"]}}},{"name":"действующее вещество","value":"Тобрамицин","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["27144131:28710358"]}}},{"name":"возраст","value":"от 2 месяцев"},{"name":"форма выпуска","value":"капли"},{"name":"страна-производитель","value":"Индия"}]}},"compactSpecs":{"17556188914587251306":{"specItems":[{"name":"Артикул Маркета","value":"3312265648","withCopyValueButton":true},{"name":"Тип препарата","value":"Рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"Назначение","value":"Бактериальные инфекции глаз","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["36476390:36617693"]}}},{"name":"Действующее вещество","value":"Тобрамицин","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["27144131:28710358"]}}},{"name":"Возраст","value":"От 2 месяцев"}]}},"fullSpecs":{"17556188914587251306":{"specItems":[{"name":"Тип препарата","value":"лекарственный препарат","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["34324371:35649313"]}}},{"name":"Рецептурный препарат","value":"да","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["27272850:1,0"]}}},{"name":"Органы и системы","value":"глаза","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["34045610:34516019"]}}},{"name":"Назначение","value":"бактериальные инфекции глаз","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["36476390:36617693"]}}},{"name":"Показания к применению","value":"Лечение инфекционных заболеваний переднего отрезка глазного яблока, вызванных чувствительными к тобрамицину микроорганизмами, у взрослых и детей старше 2 месяцев."},{"name":"Противопоказания","value":"Гиперчувствительность к компонентам препарата, период грудного вскармливания, детский возраст до 2 месяцев."},{"name":"Состав","value":"Каждый мл препарата содержит:\u003Cbr\u003EАктивное вещество: тобрамицин- 3 мг.\u003Cbr\u003EВспомогательные вещества:\u003Cbr\u003EБензалкония хлорид 0,1 мг, гипромеллоза 2,5 мг, динатрия эдетат 1,0 мг, натрия хлорид 9,0 мг, натрия гидроксид или хлористоводородная кислота до pH 7,5, вода для инъекций до 1 мл."},{"name":"Действующее вещество","value":"Тобрамицин","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["27144131:28710358"]}}},{"name":"Способ применения и дозы","value":"В случае легкого течения инфекционного процесса по 1 капле в конъюнктивальный мешок 2 раза в день (утром и вечером) в течение 7 ± 1 дней. В случае тяжелого течения инфекционного процесса в первый день по 1 капле 4 раза в день в период бодрствования, в последующем - по 1 капле в пораженный глаз дважды в день в период бодрствования, общий период лечения 7 ± 1 дней.\u003Cbr\u003EДля предотвращения контаминации кончика флакона-капельницы и раствора необходимо избегать его соприкосновения с веками, окологлазничной областью или другими поверхностями. После применения необходимо плотно закрывать флакон.\u003Cbr\u003EВ случае совместного применения с другими лекарственными средствами для местного применения в офтальмологии необходимо соблюдать интервал 5-10 минут между инстилляциями.\u003Cbr\u003EПрименение у пожилых\u003Cbr\u003EНе требуется коррекции дозы при применении у пожилых.\u003Cbr\u003EПрименение в педиатрической популяции\u003Cbr\u003EВозможно применение глазных капель тобрамицина пациентами старше 2 месяцев в тех же дозировках, что и у взрослых. Эффективность и безопасность применения препарата у пациентов младше 2 месяцев не установлена.\u003Cbr\u003EПрименение пациентами с почечной и печеночной недостаточностью\u003Cbr\u003EПри местном применении тобрамицина отмечается его низкая системная экспозиция. В случае совместного применения с системными аминогликозидными антибиотиками необходимо контролировать их уровень в плазме для поддержания требуемых системных концентраций."},{"name":"Побочные действия","value":"Наиболее часто встречающимися нежелательными явлениями при применении препарата были явления токсичности и местной гиперчувствительности, в том числе зуд век, отек век, слезотечение, конъюнктивальная инъекция.\u003Cbr\u003EСведения о нежелательных явлениях были получены в ходе клинических исследований и пострегистрационного опыта применения препарата и классифицированы согласно нижеследующей градации частоты встречаемости: очень часто (≥1/10), часто (от ≥1/100 до \u003C1/10), нечасто (от ≥1/1,000 до \u003C1/100), редко (от ≥1/10,000 до \u003C1/1,000), очень редко (\u003C1/10,000), с неизвестной частотой (частота встречаемости не может быть определена на основании имеющихся данных). В каждой группе нежелательных явлений, сгруппированных согласно частоте встречаемости, нежелательные явления представлены в порядке убывания серьезности.\u003Cbr\u003EНарушения со стороны иммунной системы\u003Cbr\u003EНечасто: гиперчувствительность.\u003Cbr\u003EНарушения со стороны нервной системы\u003Cbr\u003EНечасто: головная боль.\u003Cbr\u003EНарушения со стороны органа зрения\u003Cbr\u003EЧасто: дискомфорт в глазу, конъюнктивальная инъекция, аллергические явления со стороны органа зрения, зуд век; нечасто: кератит, эрозия роговицы, нарушение зрения, затуманивание зрения, эритема век, выделения из глаз, отек конъюнктивы, отек век, боль в глазу, синдром \"сухого\" глаза, зуд в глазу, слезотечение; с неизвестной частотой: раздражение глаз.\u003Cbr\u003EНарушения со стороны кожи и подкожно-жировой клетчатки\u003Cbr\u003EНечасто: крапивница, дерматит, мадароз, лейкодерма, зуд, сухость кожи; с неизвестной частотой: сыпь, эритема."},{"name":"Фармакологическое действие","value":"Антибиотик широкого спектра действия из группы аминогликозидов. В низких концентрациях действует бактериостатически (блокирует 30S субъединицу рибосом и нарушает синтез белка), а в более высоких - бактерицидно (нарушает синтез белка и проницаемость цитоплазматической мембраны микробной клетки, вызывая её гибель).\u003Cbr\u003EЧувствительные к тобрамицину микроорганизмы: Аэробные грамположительные микроорганизмы: Corynebacterium, Staphylococcus aureus (чувствительные к метициллину); коагулазо-негативные виды стафилококков (чувствительные к метициллину, включая устойчивые к пенициллину штаммы). Грамотрицательные бактерии: виды Acinetobacter; Escherichia coli; Haemophilus influenzae; виды Klebsiella; виды Moraxella; Morganella morganii; Pseudomonas aeruginosa.\u003Cbr\u003EРезистентные к тобрамицину микроорганизмы: Аэробные грамположительные микроорганизмы: некоторые виды Staphylococcus, устойчивые к метициллину с частотой случаев резистентности до 50% всех видов стафилококков в некоторых европейских странах; Streptococcus pneumoniae и большинство штаммов стрептококков группы D.\u003Cbr\u003EНекоторые гентамицинустойчивые штаммы сохраняют высокую чувствительность к тобрамицину.\u003Cbr\u003EВозникновение резистентности к тобрамицину является результатом модификации и инактивации антибиотиков ферментами, присутствующими в периплазматическом пространстве бактерий. Существуют три различных механизма, с помощью которых инактивируются аминогликозиды: ацетилирование аминогрупп, фосфорилирование гидроксильных групп и аденилирование гидроксильных групп.\u003Cbr\u003EТакже возможна изменчивая чувствительность между аминогликозидными антибиотиками относительно других классов модифицированных ферментов. Наиболее распространенный механизм приобретенной резистентности к аминогликозидам - это инактивация антибиотика путем модификации плазмидов и транспозон-кодированных ферментов.\u003Cbr\u003EНиже приведены критические значения минимальной ингибирующей концентрации (МИК), которые отделяют чувствительные микроорганизмы S (МИК \u003C4мг/мл) от условно-чувствительных микроорганизмов и условно¬чувствительные микроорганизмы от резистентных, R (резистентные) ≥8 мг/мл. Резистентность может изменяться географически для соответствующих видов микроорганизмов, поэтому желательно иметь местную информацию относительно резистентных микроорганизмов, в особенности при лечении тяжелых инфекций."},{"name":"Фармакологическая группа","value":"антибиотик-аминогликозид"},{"name":"Форма выпуска","value":"капли"},{"name":"Способ применения/введения","value":"конъюктивальный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["35947170:36763746"]}}},{"name":"Минимальный возраст применения","value":"от 2 месяцев"},{"name":"Условия хранения","value":"При температуре не выше 30°С в защищенном от света месте. Не замораживать.\u003Cbr\u003EХранить в местах, недоступных для детей."},{"name":"Передозировка","value":"Не ожидается токсических явлений при местном офтальмологическом применении препарата или в случае случайного проглатывания содержимого флакона. Клинические проявления передозировки при применении тобрамицина в виде инстилляций (в том числе точечный кератит, эритема век, слезотечение, отек конъюнктивы, зуд век) могут быть аналогичны нежелательным явлениям, которые отмечались у ряда пациентов в ходе лечения препаратом."},{"name":"Применение при беременности и кормлении грудью","value":"Фертильность\u003Cbr\u003EНе проводилось клинических исследований по изучению влияния тобрамицина в лекарственной форме капли глазные на фертильность у человека.\u003Cbr\u003EБеременность\u003Cbr\u003EПри пероральном применении тобрамицина в дозах, значительно превышающих таковые для применения в виде инстилляций, отмечены явления нефро- и ототоксичности. Тобрамицин при пероральном применении проникает через плаценту в амниотическую жидкость и кровь плода. В исследовании парентерального применения антибиотиков-аминогликозидов, включая тобрамицин, не отмечено рисков для плода. Не ожидается высокого уровня тобрамицина в плазме после применения в виде инстилляций.\u003Cbr\u003EСведения о применении препарата в терапии беременных женщин отсутствуют или ограничены. В исследованиях на животных получены сведения о репродуктивной токсичности. Не рекомендовано применение препарата в период беременности.\u003Cbr\u003EПериод грудного вскармливания\u003Cbr\u003EТобрамицин экскретируется в грудное молоко в значительном количестве при пероральном и парентеральном применении. При применении в виде инстилляций системная экспозиция препарата низкая, что делает маловероятным экскрецию тобрамицина в грудное молоко. Необходимо прекратить грудное вскармливание или прервать/прекратить терапию препаратом, принимая во внимание пользу терапии для матери и пользу грудного вскармливания для ребенка."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Если после применения капель у пациентов временно снижается четкость зрения, до ее восстановления не рекомендуется управлять транспортными средствами и заниматься видами деятельности, требующими повышенного внимания и реакции."},{"name":"Особые указания","value":"Только для местного применения в офтальмологии. Препарат не предназначен для применения в виде инъекций или перорального применения.\u003Cbr\u003EГиперчувствительность к аминогликозидам для местного применения в офтальмологии отмечена у ряда пациентов. При развитии симптомов гиперчувствительности необходимо прекратить применение препарата. Отмечена перекрестная чувствительность к другим аминогликозидам, поэтому необходимо принять во внимание, что в случае развития гиперчувствительности к тобрамицину возможна гиперчувствительность к другим аминогликозидам для местного или системного применения.\u003Cbr\u003EОтмечались серьезные нежелательные реакции, такие как нейротоксичность, ототоксичность и нефротоксичность, при пероральном применении тобрамицина. Требуется соблюдать осторожность при совместном применении с другими аминогликозидами. Как и при длительном применении других антибиотиков, возможен избыточный рост нечувствительных к тобрамицину микроорганизмов, в том числе грибов. В случае развития суперинфекции применение препарата необходимо прекратить.\u003Cbr\u003EНе рекомендуется ношение контактных линз в период лечения инфекционных заболеваний органа зрения.\u003Cbr\u003EВ состав препарата входит бензалкония хлорид, который может вызывать раздражение глаз и обесцвечивать мягкие контактные линзы. Следует избегать контакта препарата с мягкими контактными линзами. Пациентов необходимо проинструктировать снимать контактные линзы перед применением препарата и снова надевать их не ранее, чем через 15 минут после инстилляции."},{"name":"Взаимодействие","value":"Исследований взаимодействия препарата с другими лекарственными средствами не проводилось. При совместном применении офтальмологических форм тобрамицина и кортикостероидов для местного применения в офтальмологии могут маскироваться клинические симптомы бактериальных, грибковых и вирусных заболеваний органа зрения, а также подавляться реакции гиперчувствительности."},{"name":"Регистрационный номер","value":"ЛП-000202"},{"name":"Дата государственной регистрации","value":"23.04.2018"},{"name":"Владелец регистрационного удостоверения","value":"Sentiss Pharma Pvt. Ltd.","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["34324371:35649313","7893318:16228200"]}}},{"name":"Изготовитель","value":"Sentiss Pharma Pvt. Ltd."},{"name":"Фасовщик","value":"Sentiss Pharma Pvt. Ltd."},{"name":"Страна бренда","value":"Индия"},{"name":"Страна-производитель","value":"Индия"},{"name":"Название препарата","value":"Тобрисс","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["17796364:18048881"]}}},{"name":"Срок годности","value":"24 мес."}]}},"fullSpecsGrouped":{"17556188914587251306":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"глаза"},{"name":"Назначение","value":"бактериальные инфекции глаз"},{"name":"Показания к применению","value":"Лечение инфекционных заболеваний переднего отрезка глазного яблока, вызванных чувствительными к тобрамицину микроорганизмами, у взрослых и детей старше 2 месяцев."},{"name":"Противопоказания","value":"Гиперчувствительность к компонентам препарата, период грудного вскармливания, детский возраст до 2 месяцев."},{"name":"Состав","value":"Каждый мл препарата содержит:\u003Cbr\u003EАктивное вещество: тобрамицин- 3 мг.\u003Cbr\u003EВспомогательные вещества:\u003Cbr\u003EБензалкония хлорид 0,1 мг, гипромеллоза 2,5 мг, динатрия эдетат 1,0 мг, натрия хлорид 9,0 мг, натрия гидроксид или хлористоводородная кислота до pH 7,5, вода для инъекций до 1 мл."},{"name":"Действующее вещество","value":"Тобрамицин"},{"name":"Способ применения и дозы","value":"В случае легкого течения инфекционного процесса по 1 капле в конъюнктивальный мешок 2 раза в день (утром и вечером) в течение 7 ± 1 дней. В случае тяжелого течения инфекционного процесса в первый день по 1 капле 4 раза в день в период бодрствования, в последующем - по 1 капле в пораженный глаз дважды в день в период бодрствования, общий период лечения 7 ± 1 дней.\u003Cbr\u003EДля предотвращения контаминации кончика флакона-капельницы и раствора необходимо избегать его соприкосновения с веками, окологлазничной областью или другими поверхностями. После применения необходимо плотно закрывать флакон.\u003Cbr\u003EВ случае совместного применения с другими лекарственными средствами для местного применения в офтальмологии необходимо соблюдать интервал 5-10 минут между инстилляциями.\u003Cbr\u003EПрименение у пожилых\u003Cbr\u003EНе требуется коррекции дозы при применении у пожилых.\u003Cbr\u003EПрименение в педиатрической популяции\u003Cbr\u003EВозможно применение глазных капель тобрамицина пациентами старше 2 месяцев в тех же дозировках, что и у взрослых. Эффективность и безопасность применения препарата у пациентов младше 2 месяцев не установлена.\u003Cbr\u003EПрименение пациентами с почечной и печеночной недостаточностью\u003Cbr\u003EПри местном применении тобрамицина отмечается его низкая системная экспозиция. В случае совместного применения с системными аминогликозидными антибиотиками необходимо контролировать их уровень в плазме для поддержания требуемых системных концентраций."},{"name":"Побочные действия","value":"Наиболее часто встречающимися нежелательными явлениями при применении препарата были явления токсичности и местной гиперчувствительности, в том числе зуд век, отек век, слезотечение, конъюнктивальная инъекция.\u003Cbr\u003EСведения о нежелательных явлениях были получены в ходе клинических исследований и пострегистрационного опыта применения препарата и классифицированы согласно нижеследующей градации частоты встречаемости: очень часто (≥1/10), часто (от ≥1/100 до \u003C1/10), нечасто (от ≥1/1,000 до \u003C1/100), редко (от ≥1/10,000 до \u003C1/1,000), очень редко (\u003C1/10,000), с неизвестной частотой (частота встречаемости не может быть определена на основании имеющихся данных). В каждой группе нежелательных явлений, сгруппированных согласно частоте встречаемости, нежелательные явления представлены в порядке убывания серьезности.\u003Cbr\u003EНарушения со стороны иммунной системы\u003Cbr\u003EНечасто: гиперчувствительность.\u003Cbr\u003EНарушения со стороны нервной системы\u003Cbr\u003EНечасто: головная боль.\u003Cbr\u003EНарушения со стороны органа зрения\u003Cbr\u003EЧасто: дискомфорт в глазу, конъюнктивальная инъекция, аллергические явления со стороны органа зрения, зуд век; нечасто: кератит, эрозия роговицы, нарушение зрения, затуманивание зрения, эритема век, выделения из глаз, отек конъюнктивы, отек век, боль в глазу, синдром \"сухого\" глаза, зуд в глазу, слезотечение; с неизвестной частотой: раздражение глаз.\u003Cbr\u003EНарушения со стороны кожи и подкожно-жировой клетчатки\u003Cbr\u003EНечасто: крапивница, дерматит, мадароз, лейкодерма, зуд, сухость кожи; с неизвестной частотой: сыпь, эритема."},{"name":"Фармакологическое действие","value":"Антибиотик широкого спектра действия из группы аминогликозидов. В низких концентрациях действует бактериостатически (блокирует 30S субъединицу рибосом и нарушает синтез белка), а в более высоких - бактерицидно (нарушает синтез белка и проницаемость цитоплазматической мембраны микробной клетки, вызывая её гибель).\u003Cbr\u003EЧувствительные к тобрамицину микроорганизмы: Аэробные грамположительные микроорганизмы: Corynebacterium, Staphylococcus aureus (чувствительные к метициллину); коагулазо-негативные виды стафилококков (чувствительные к метициллину, включая устойчивые к пенициллину штаммы). Грамотрицательные бактерии: виды Acinetobacter; Escherichia coli; Haemophilus influenzae; виды Klebsiella; виды Moraxella; Morganella morganii; Pseudomonas aeruginosa.\u003Cbr\u003EРезистентные к тобрамицину микроорганизмы: Аэробные грамположительные микроорганизмы: некоторые виды Staphylococcus, устойчивые к метициллину с частотой случаев резистентности до 50% всех видов стафилококков в некоторых европейских странах; Streptococcus pneumoniae и большинство штаммов стрептококков группы D.\u003Cbr\u003EНекоторые гентамицинустойчивые штаммы сохраняют высокую чувствительность к тобрамицину.\u003Cbr\u003EВозникновение резистентности к тобрамицину является результатом модификации и инактивации антибиотиков ферментами, присутствующими в периплазматическом пространстве бактерий. Существуют три различных механизма, с помощью которых инактивируются аминогликозиды: ацетилирование аминогрупп, фосфорилирование гидроксильных групп и аденилирование гидроксильных групп.\u003Cbr\u003EТакже возможна изменчивая чувствительность между аминогликозидными антибиотиками относительно других классов модифицированных ферментов. Наиболее распространенный механизм приобретенной резистентности к аминогликозидам - это инактивация антибиотика путем модификации плазмидов и транспозон-кодированных ферментов.\u003Cbr\u003EНиже приведены критические значения минимальной ингибирующей концентрации (МИК), которые отделяют чувствительные микроорганизмы S (МИК \u003C4мг/мл) от условно-чувствительных микроорганизмов и условно¬чувствительные микроорганизмы от резистентных, R (резистентные) ≥8 мг/мл. Резистентность может изменяться географически для соответствующих видов микроорганизмов, поэтому желательно иметь местную информацию относительно резистентных микроорганизмов, в особенности при лечении тяжелых инфекций."},{"name":"Фармакологическая группа","value":"антибиотик-аминогликозид"},{"name":"Форма выпуска","value":"капли"},{"name":"Способ применения/введения","value":"конъюктивальный"},{"name":"Минимальный возраст применения","value":"от 2 месяцев"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"При температуре не выше 30°С в защищенном от света месте. Не замораживать.\u003Cbr\u003EХранить в местах, недоступных для детей."},{"name":"Передозировка","value":"Не ожидается токсических явлений при местном офтальмологическом применении препарата или в случае случайного проглатывания содержимого флакона. Клинические проявления передозировки при применении тобрамицина в виде инстилляций (в том числе точечный кератит, эритема век, слезотечение, отек конъюнктивы, зуд век) могут быть аналогичны нежелательным явлениям, которые отмечались у ряда пациентов в ходе лечения препаратом."},{"name":"Применение при беременности и кормлении грудью","value":"Фертильность\u003Cbr\u003EНе проводилось клинических исследований по изучению влияния тобрамицина в лекарственной форме капли глазные на фертильность у человека.\u003Cbr\u003EБеременность\u003Cbr\u003EПри пероральном применении тобрамицина в дозах, значительно превышающих таковые для применения в виде инстилляций, отмечены явления нефро- и ототоксичности. Тобрамицин при пероральном применении проникает через плаценту в амниотическую жидкость и кровь плода. В исследовании парентерального применения антибиотиков-аминогликозидов, включая тобрамицин, не отмечено рисков для плода. Не ожидается высокого уровня тобрамицина в плазме после применения в виде инстилляций.\u003Cbr\u003EСведения о применении препарата в терапии беременных женщин отсутствуют или ограничены. В исследованиях на животных получены сведения о репродуктивной токсичности. Не рекомендовано применение препарата в период беременности.\u003Cbr\u003EПериод грудного вскармливания\u003Cbr\u003EТобрамицин экскретируется в грудное молоко в значительном количестве при пероральном и парентеральном применении. При применении в виде инстилляций системная экспозиция препарата низкая, что делает маловероятным экскрецию тобрамицина в грудное молоко. Необходимо прекратить грудное вскармливание или прервать/прекратить терапию препаратом, принимая во внимание пользу терапии для матери и пользу грудного вскармливания для ребенка."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Если после применения капель у пациентов временно снижается четкость зрения, до ее восстановления не рекомендуется управлять транспортными средствами и заниматься видами деятельности, требующими повышенного внимания и реакции."},{"name":"Особые указания","value":"Только для местного применения в офтальмологии. Препарат не предназначен для применения в виде инъекций или перорального применения.\u003Cbr\u003EГиперчувствительность к аминогликозидам для местного применения в офтальмологии отмечена у ряда пациентов. При развитии симптомов гиперчувствительности необходимо прекратить применение препарата. Отмечена перекрестная чувствительность к другим аминогликозидам, поэтому необходимо принять во внимание, что в случае развития гиперчувствительности к тобрамицину возможна гиперчувствительность к другим аминогликозидам для местного или системного применения.\u003Cbr\u003EОтмечались серьезные нежелательные реакции, такие как нейротоксичность, ототоксичность и нефротоксичность, при пероральном применении тобрамицина. Требуется соблюдать осторожность при совместном применении с другими аминогликозидами. Как и при длительном применении других антибиотиков, возможен избыточный рост нечувствительных к тобрамицину микроорганизмов, в том числе грибов. В случае развития суперинфекции применение препарата необходимо прекратить.\u003Cbr\u003EНе рекомендуется ношение контактных линз в период лечения инфекционных заболеваний органа зрения.\u003Cbr\u003EВ состав препарата входит бензалкония хлорид, который может вызывать раздражение глаз и обесцвечивать мягкие контактные линзы. Следует избегать контакта препарата с мягкими контактными линзами. Пациентов необходимо проинструктировать снимать контактные линзы перед применением препарата и снова надевать их не ранее, чем через 15 минут после инстилляции."},{"name":"Взаимодействие","value":"Исследований взаимодействия препарата с другими лекарственными средствами не проводилось. При совместном применении офтальмологических форм тобрамицина и кортикостероидов для местного применения в офтальмологии могут маскироваться клинические симптомы бактериальных, грибковых и вирусных заболеваний органа зрения, а также подавляться реакции гиперчувствительности."},{"name":"Регистрационный номер","value":"ЛП-000202"},{"name":"Дата государственной регистрации","value":"23.04.2018"},{"name":"Владелец регистрационного удостоверения","value":"Sentiss Pharma Pvt. Ltd."},{"name":"Изготовитель","value":"Sentiss Pharma Pvt. Ltd."},{"name":"Фасовщик","value":"Sentiss Pharma Pvt. Ltd."},{"name":"Страна бренда","value":"Индия"},{"name":"Страна-производитель","value":"Индия"},{"name":"Название препарата","value":"Тобрисс"},{"name":"Срок годности","value":"24 мес."}]}],"transitionId":"tr_6561080638255334591"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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    Цена 138 ₽ вместо 163
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  • Тобрадекс гл. капли, 5 мл
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    Тобрадекс гл. капли, 5 мл

    Рейтинг товара: 5 из 5
    на основе 14 оценок
    Цена 666 ₽
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  • Тобропт гл. капли, 0.3%, 5 мл, 1 шт.
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    Тобропт гл. капли, 0.3%, 5 мл, 1 шт.

    Цена 155 ₽
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  • Ципромед гл. капли, 0.3%, 5 мл, 1 шт.
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    Ципромед гл. капли, 0.3%, 5 мл, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 4 оценки
    Цена 136 ₽
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  • Сульфацил натрия (Альбуцид) гл. капли, 20%, 10 мл
    –1 %
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    Сульфацил натрия (Альбуцид) гл. капли, 20%, 10 мл

    Рейтинг товара: 4.9 из 5
    на основе 21 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 140 ₽ вместо 141
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  • Окомистин гл. капли фл.-капельница, 0,01%, 10 мл, 1 шт.
    –20 %
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    Окомистин гл. капли фл.-капельница, 0,01%, 10 мл, 1 шт.

    Рейтинг товара: 4.9 из 5
    на основе 14 оценок
    Цена 349 ₽ вместо 436
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  • Корфецин-СОЛОфарм гл. капли фл., 0.5%, 5 мл, 1 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-n6mwmvyvs7/toggleWishlist":{"skuId":"687076028","productId":1778174418,"offerId":"lMUVxjQZEl90tmfhcGwRGA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ+KjKktb8mpVjEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYI0pPzzwYQvOXPxwIYh97QByDc3MEH","sign":"JVEz3vPTMiR9GteR7E68VYZiYWSdu9hRarK5gm9Ak/M="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-n6mwmvyvs7/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Корфецин-СОЛОфарм гл. капли фл., 0.5%, 5 мл, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 109 ₽
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  • Дефислез гл. капли фл., 3 мг/мл, 10 мл, 1 шт.
    –2 %
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    Дефислез гл. капли фл., 3 мг/мл, 10 мл, 1 шт.

    Рейтинг товара: 4.8 из 5
    на основе 65 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 59 ₽ вместо 60
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  • Офтальмоферон гл. капли, 10 мл, 10 мл
    –1 %
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    Офтальмоферон гл. капли, 10 мл, 10 мл

    Рейтинг товара: 5 из 5
    на основе 13 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 346 ₽ вместо 349
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  • Инокаин гл. капли, 0.4%, 5 мл
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    Инокаин гл. капли, 0.4%, 5 мл

    Рейтинг товара: 5 из 5
    на основе 5 оценок
    Цена 132 ₽
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  • Дикло-Ф гл. капли фл.-капельница, 0.1%, 5 мл
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-008uo7iwg8pe3/toggleWishlist":{"skuId":"228042557","productId":1778174357,"offerId":"4MHuS-nAze9WkyrQtCzVng","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ+KjKktb8mpVjEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIlZPzzwYQvc7ebBjovt4HINzcwQc=","sign":"t/XlQGgi0XXxajhsOz357vDx8ucsHXQ7l2l8akDjYfc="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-008uo7iwg8pe3/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Дикло-Ф гл. капли фл.-капельница, 0.1%, 5 мл

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 156 ₽
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Инструкция

Показания к применению

Лечение инфекционных заболеваний переднего отрезка глазного яблока, вызванных чувствительными к тобрамицину микроорганизмами, у взрослых и детей старше 2 месяцев.

Противопоказания

Гиперчувствительность к компонентам препарата, период грудного вскармливания, детский возраст до 2 месяцев.

Способ применения и дозы

В случае легкого течения инфекционного процесса по 1 капле в конъюнктивальный мешок 2 раза в день (утром и вечером) в течение 7 ± 1 дней. В случае тяжелого течения инфекционного процесса в первый день по 1 капле 4 раза в день в период бодрствования, в последующем - по 1 капле в пораженный глаз дважды в день в период бодрствования, общий период лечения 7 ± 1 дней.
Для предотвращения контаминации кончика флакона-капельницы и раствора необходимо избегать его соприкосновения с веками, окологлазничной областью или другими поверхностями. После применения необходимо плотно закрывать флакон.
В случае совместного применения с другими лекарственными средствами для местного применения в офтальмологии необходимо соблюдать интервал 5-10 минут между инстилляциями.
Применение у пожилых
Не требуется коррекции дозы при применении у пожилых.
Применение в педиатрической популяции
Возможно применение глазных капель тобрамицина пациентами старше 2 месяцев в тех же дозировках, что и у взрослых. Эффективность и безопасность применения препарата у пациентов младше 2 месяцев не установлена.
Применение пациентами с почечной и печеночной недостаточностью
При местном применении тобрамицина отмечается его низкая системная экспозиция. В случае совместного применения с системными аминогликозидными антибиотиками необходимо контролировать их уровень в плазме для поддержания требуемых системных концентраций.
Полная инструкция
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Тобрисс гл. капли фл.- капельница
Тобрисс гл. капли фл.- капельница, 0.3%, 5 мл, 1 шт.
У продавца: 
нет • На Маркете: 5.0
(7)
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Задать вопрос
Инструкция

159 ₽

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