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Описание

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Цефотаксим пор. д/приг. р-ра для в/в и в/м введ., 1 г, 1 г, 1 шт.

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Коротко о товаре

Артикул Маркета
4453152422
Тип препарата
Назначение
Действующее вещество
Возраст
от 12 лет
Инструкция
{"widgets":{"@card/SpecsList":{"/content/page/fancyPage/productSpecsList":{"wrapperProps":{"margins":{"top":4,"bottom":4}},"specsLimit":5,"title":"Коротко о товаре","titleSize":"14","type":"minimal","offset":"s","isHealthCategory":true,"forceShowWidget":true,"withFridge":true}}},"meta":{"/content/page/fancyPage/productSpecsList":{"name":"@card/SpecsList"}},"collections":{"minimalSpecs":{"7301721041440981241":{"specItems":[{"name":"Артикул Маркета","value":"4453152422","withCopyValueButton":true},{"name":"тип препарата","value":"рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"назначение","value":"бактериальные инфекции, бронхит, инфекции органов малого таза, перитонит, пневмония, сепсис","transition":{"type":"list","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["36476390:36618866,36618778,36618101,36617984,36617928,36617650"]}}},{"name":"действующее вещество","value":"Цефотаксим","transition":{"type":"list","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["27144131:28708539"]}}},{"name":"возраст","value":"от 12 лет"},{"name":"форма выпуска","value":"порошок для приготовления раствора для инъекций"},{"name":"страна-производитель","value":"Россия"}]}},"compactSpecs":{"7301721041440981241":{"specItems":[{"name":"Артикул Маркета","value":"4453152422","withCopyValueButton":true},{"name":"Тип препарата","value":"Рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"Действующее вещество","value":"Цефотаксим","transition":{"type":"list","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["27144131:28708539"]}}},{"name":"Возраст","value":"От 12 лет"},{"name":"Страна-производитель","value":"Россия"}]}},"fullSpecs":{"7301721041440981241":{"specItems":[{"name":"Тип препарата","value":"лекарственный препарат","transition":{"type":"catalog","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["34324371:35649313"]}}},{"name":"Рецептурный препарат","value":"да","transition":{"type":"catalog","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["27272850:1,0"]}}},{"name":"Назначение","value":"бактериальные инфекции, бронхит, инфекции органов малого таза, перитонит, пневмония, сепсис","transition":{"type":"catalog","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["36476390:36618866,36618778,36618101,36617984,36617928,36617650"]}}},{"name":"Органы и системы","value":"дыхательная система, кожа, кровеносная система, мочевой пузырь, мочеточники, нервная система, опорно-двигательная система, пищеварительная система, половая система, почки, сердце"},{"name":"Показания к применению","value":"Инфекционно-воспалительные заболевания тяжелого течения, вызванные чувствительными к цефотаксиму микроорганизмами, в т.ч. перитонит, сепсис, абдоминальные инфекции и инфекции органов малого таза, инфекции нижних отделов дыхательных путей, мочевыводящих путей, инфекции костей и суставов, кожи и мягких тканей, инфицированные раны и ожоги, гонорея, менингит, болезнь Лайма.\u003Cbr\u003EПрофилактика инфекций после оперативного вмешательства."},{"name":"Противопоказания","value":"- Повышенная чувствительность к цефотаксиму и другим цефалоспоринам.\u003Cbr /\u003EДля форм, содержащих в качестве растворителя лидокаин:\u003Cbr /\u003E- повышенная чувствительность к лидокаину или другому местному анестетику амидного типа;\u003Cbr /\u003E- внутрисердечные блокады без установленного водителя ритма;\u003Cbr /\u003E- тяжелая сердечная недостаточность;\u003Cbr /\u003E- внутривенное введение;\u003Cbr /\u003E- детский возраст до 2,5 лет (для внутримышечного введения\u003Cbr /\u003EС осторожностью:\u003Cbr /\u003E- У пациентов, имеющих в анамнезе указания на аллергию к пенициллинам (риск развития перекрестных аллергических реакций);\u003Cbr /\u003E- при одновременном применении с аминогликозидами;\u003Cbr /\u003E- при почечной недостаточности."},{"name":"Состав","value":"Действующее вещество: Цефотаксим натрия - 1,048 г в пересчете на цефотаксим - 1,0 г."},{"name":"Действующее вещество","value":"Цефотаксим","transition":{"type":"catalog","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["27144131:28708539"]}}},{"name":"Способ применения и дозы","value":"Препарат вводят внутривенно (струйно или капельно) и внутримышечно.\u003Cbr\u003E\nВзрослым и детям старше 12 лет (с массой тела 50 кг и более): при неосложненных инфекциях, а также при инфекциях мочевыводящих путей - внутримышечно или внутривенно, по 1 г каждые 8-12 ч; при неосложненной острой гонорее - внутримышечно, 1 г однократно; при инфекциях средней тяжести - внутримышечно или внутривенно, по 1-2 г каждые 12 ч; при тяжелом течении инфекций, например при менингите - внутривенно, по 2 г каждые 4-8 ч, максимальная суточная доза - 12 г. Продолжительность лечения устанавливают индивидуально.\u003Cbr\u003E\nС целью профилактики развития инфекций перед хирургической операцией вводят во время вводного наркоза однократно 1 г. При необходимости, введение повторяют через 6-12 ч. При кесаревом сечении - в момент наложения зажимов на пупочную вену -внутривенно, 1 г, затем через 6 и 12 ч после первой дозы - дополнительно по 1 г.\u003Cbr\u003E\nПри клиренсе креатинина 20 мл/мин/1,73 м2 и менее, суточную дозу уменьшают в 2раза.\u003Cbr\u003E\nНедоношенным и новорожденным до 1 недели - внутривенно, 50 мг/кг каждые 12 ч; в возрасте 1-4 недели - внутривенно, 50 мг/кг каждые 8 ч; детям, массой тела до 50 кг -внутривенно или внутримышечно, 50-180 мг/кг в 4-6 введений. При тяжелом течении инфекций, в том числе при менингите, суточную дозу детям увеличивают до 100-200 мг/кг, внутримышечно или внутривенно, в 4-6 приемов, максимальная суточная доза- 12 г.\u003Cbr\u003E\nПравила приготовления инъекционных растворов:\u003Cbr\u003E\n- для внутривенной инъекции в качестве растворителя используют воду для инъекций (0,5-1 г разводят в 4 мл растворителя, 2 г - в 10 мл); препарат вводят медленно в течение 3-5 мин.\u003Cbr\u003E\n- для внутривенной инфузии в качестве растворителя используют 0,9 % раствор NaCl или 5 % раствор декстрозы (1-2 г разводят в 50-100 мл растворителя).\u003Cbr\u003EПродолжительность инфузии - 50-60 минут;\u003Cbr\u003E\n- для внутримышечного введения используют воду для инъекций или 1 % раствор лидокаина (для дозы препарата 0,5 г - 2 мл, для дозы 1 г - 4 мл)."},{"name":"Побочные действия","value":"Аллергические реакции: крапивница, озноб или лихорадка, сыпь, кожный зуд, редко - бронхоспазм, эозинофилия, злокачественная экссудативная эритема (синдром Стивенса-Джонсона), токсический эпидермальный некролиз (синдром Лайелла), ангионевротический отек, анафилактический шок.\u003Cbr\u003EСо стороны центральной нервной системы: головная боль, головокружение.\u003Cbr\u003EСо стороны мочевыделительной системы: нарушение функции почек, олигурия, интерстициальный нефрит.\u003Cbr\u003EСо стороны желудочно-кишечного тракта: тошнота, рвота, диарея или запоры, метеоризм, боль в животе, дисбактериоз, нарушение функции печени, редко - стоматит, глоссит, псевдомембранозный энтероколит.\u003Cbr\u003EСо стороны органов кроветворения: гемолитическая анемия, лейкопения, нейтропения, гранулоцитопения, тромбоцитопения, агранулоцитоз, гипокоагуляция.\u003Cbr\u003EСо стороны сердечно-сосудистой системы: потенциально жизнеопасные аритмии после быстрого болюсного введения в центральную вену.\u003Cbr\u003EЛабораторные показатели: азотемия, повышение концентрации мочевины в крови, повышение активности \"печеночных\" трансаминаз и щелочной фосфатазы, гиперкреатининемия, гипербилирубинемия, положительная реакция Кумбса.\u003Cbr\u003EМестные реакции: флебит, болезненность по ходу вены, болезненность и инфильтрат в месте внутримышечного введения.\u003Cbr\u003EПрочее: суперинфекция (в частности, вагинальный и оральный кандидоз)."},{"name":"Фармакологическое действие","value":"Действует бактерицидно, нарушая синтез мукопептида клеточной стенки микроорганизмов. Обладает широким спектром действия. Активен в отношении грамположительных и грамотрицательных микроорганизмов, устойчивых к другим антибиотикам: Staphylococcus spp. (в том числе Staphylococcus aureus, включая штаммы, образующие пенициллиназу), Staphylococcus epidermidis (за исключением Staphylococcus epidermidis и Staphylococcus aureus, устойчивых к метициллину), Streptococcus pneumoniae, Streptococcus pyogenes (бета-гемолитические стрептококки группы А), Streptococcus agalactiae (стрептококки группы В), Enterococcus spp., Enterobacter spp., Escherichia coli, Haemophilus influenzae (в том числе штаммы, образующие пенициллиназу), Haemophilus parainfluenzae, Moraxella catarrhalis, Klebsiella spp. (в том числе Klebsiella pneumoniae, Klebsiella oxytoca), Morganella morganii, Neisseria gonorrhoeae (в том числе штаммы, образующие пенициллиназу), Acinetobacter spp., Corynebacterium diphtheriae, Erysipelothrix rhusiopathiae, Eubacter spp., Propionibacterium spp., Clostridium spp. (в том числе Clostridium perfringens), Citrobacter spp., Proteus mirabilis, Proteus vulgaris, Providencia spp. (в том числе Providencia rettgeri), Serratia spp., некоторых штаммов Pseudomonas aeruginosa, Neisseria meningitidis, Neisseria gonorrhoeae, Bacteroides spp. (в том числе некоторые штаммы Bacteroides fragilis), Fusobacterium spp. (в том числе Fusobacterium nucleatum), Peptococcus spp., Peptostreptococcus spp. Непостоянно влияет на некоторые штаммы Pseudomonas aeruginosa, Acinetobacter, Helicobacter pylori, Bacteroides fragilis, Clostridium difficile. Устойчив к большинству бета-лактамаз грамположительных и грамотрицательных микроорганизмов."},{"name":"Фармакологическая группа","value":"антибиотики"},{"name":"Форма выпуска","value":"порошок для приготовления раствора для инъекций"},{"name":"Способ применения/введения","value":"парентеральный","transition":{"type":"catalog","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["35947170:36763748"]}}},{"name":"Минимальный возраст применения","value":"от 12 лет"},{"name":"Условия хранения","value":"В сухом, защищенном от света месте при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы: судороги, энцефалопатия (в случае введения больших доз, особенно у больных с почечной недостаточностью), тремор, нервно-мышечная возбудимость.\u003Cbr\u003EЛечение: симптоматическое, специфического антидота нет."},{"name":"Применение при беременности и кормлении грудью","value":"Беременность\u003Cbr /\u003EЦефотаксим проникает через плацентарный барьер. Исследования, проведенные на животных, не выявили тератогенного или фетотоксического действия препарата. Однако безопасность применения цефотаксима при беременности у человека не установлена, поэтому препарат не должен использоваться во время беременности.\u003Cbr /\u003EПериод грудного вскармливания\u003Cbr /\u003EЦефотаксим проникает в грудное молоко, поэтому при необходимости применения препарата грудное вскармливание следует прекратить."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В случае развития такого побочного эффекта как головокружение может нарушаться способность к концентрации внимания и реакциям. В таком случае пациентам следует воздержаться от вождения автотранспорта и работы с механизмами."},{"name":"Особые указания","value":"- в первые недели лечения может возникнуть псевдомембранозный колит, проявляющийся тяжелой длительной диареей. При этом прекращают прием препарата и назначают адекватную терапию, включая ванкомицин или метронидазол;\u003Cbr\u003E- пациенты, имевшие в анамнезе аллергические реакции на пенициллины, могут иметь повышенную чувствительность к цефалоспориновым антибиотикам;\u003Cbr\u003E- при лечении препаратом свыше 10 дней необходим контроль картины периферической крови. Во время лечения цефотаксимом возможно получение ложноположительной пробы Кумбса и ложноположительной реакции мочи на глюкозу;\u003Cbr\u003E- при необходимости назначения препарата в период лактации, следует прекратить грудное вскармливание;\u003Cbr\u003E- во время лечения нельзя употреблять этанол - возможны эффекты, сходные с действие дисульфирама (гиперемия лица, спазм в животе и в области желудка, тошнота, рвота, головная боль, снижение артериального давления, тахикардия, одышка)."},{"name":"Взаимодействие","value":"Цефотаксим, подавляя кишечную флору, препятствует синтезу витамина К. Поэтому при одновременном применении с препаратами, снижающими агрегацию тромбоцитов (НПВС, салицилаты, сульфинпиразон), увеличивается риск развития кровотечений. По этой же причине при одновременном применении с антикоагулянтами отмечается усиление антикоагулянтного действия.\u003Cbr\u003EПри одновременном применении с аминогликозидами, полимиксином B и \"петлевыми\" диуретиками повышается риск поражения почек.\u003Cbr\u003EПри одновременном применении с препаратами, уменьшающими канальцевую секрецию, повышается концентрация цефотаксима в плазме крови.\u003Cbr\u003EПробенецид замедляет выведение цефотаксима за счет снижения канальцевой секреции последнего."},{"name":"Источник","value":"\u003Ca href=\"https://www.vidal.ru\" target=\"_blank\"\u003EСправочник лекарственных препаратов Видаль<\u002Fa\u003E"},{"name":"Регистрационный номер","value":"ЛСР-008487/08"},{"name":"Дата государственной регистрации","value":"14.10.2019"},{"name":"Владелец регистрационного удостоверения","value":"ЛЕККО","transition":{"type":"catalog","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["34324371:35649313","7893318:16001540"]}}},{"name":"Изготовитель","value":"ЛЕККО"},{"name":"Фасовщик","value":"ЛЕККО"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Цефотаксим","transition":{"type":"catalog","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["17796364:18038500"]}}},{"name":"Срок годности","value":"574 дн."}]}},"fullSpecsGrouped":{"7301721041440981241":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Назначение","value":"бактериальные инфекции, бронхит, инфекции органов малого таза, перитонит, пневмония, сепсис"},{"name":"Органы и системы","value":"дыхательная система, кожа, кровеносная система, мочевой пузырь, мочеточники, нервная система, опорно-двигательная система, пищеварительная система, половая система, почки, сердце"},{"name":"Показания к применению","value":"Инфекционно-воспалительные заболевания тяжелого течения, вызванные чувствительными к цефотаксиму микроорганизмами, в т.ч. перитонит, сепсис, абдоминальные инфекции и инфекции органов малого таза, инфекции нижних отделов дыхательных путей, мочевыводящих путей, инфекции костей и суставов, кожи и мягких тканей, инфицированные раны и ожоги, гонорея, менингит, болезнь Лайма.\u003Cbr\u003EПрофилактика инфекций после оперативного вмешательства."},{"name":"Противопоказания","value":"- Повышенная чувствительность к цефотаксиму и другим цефалоспоринам.\u003Cbr /\u003EДля форм, содержащих в качестве растворителя лидокаин:\u003Cbr /\u003E- повышенная чувствительность к лидокаину или другому местному анестетику амидного типа;\u003Cbr /\u003E- внутрисердечные блокады без установленного водителя ритма;\u003Cbr /\u003E- тяжелая сердечная недостаточность;\u003Cbr /\u003E- внутривенное введение;\u003Cbr /\u003E- детский возраст до 2,5 лет (для внутримышечного введения\u003Cbr /\u003EС осторожностью:\u003Cbr /\u003E- У пациентов, имеющих в анамнезе указания на аллергию к пенициллинам (риск развития перекрестных аллергических реакций);\u003Cbr /\u003E- при одновременном применении с аминогликозидами;\u003Cbr /\u003E- при почечной недостаточности."},{"name":"Состав","value":"Действующее вещество: Цефотаксим натрия - 1,048 г в пересчете на цефотаксим - 1,0 г."},{"name":"Действующее вещество","value":"Цефотаксим"},{"name":"Способ применения и дозы","value":"Препарат вводят внутривенно (струйно или капельно) и внутримышечно.\u003Cbr\u003E\nВзрослым и детям старше 12 лет (с массой тела 50 кг и более): при неосложненных инфекциях, а также при инфекциях мочевыводящих путей - внутримышечно или внутривенно, по 1 г каждые 8-12 ч; при неосложненной острой гонорее - внутримышечно, 1 г однократно; при инфекциях средней тяжести - внутримышечно или внутривенно, по 1-2 г каждые 12 ч; при тяжелом течении инфекций, например при менингите - внутривенно, по 2 г каждые 4-8 ч, максимальная суточная доза - 12 г. Продолжительность лечения устанавливают индивидуально.\u003Cbr\u003E\nС целью профилактики развития инфекций перед хирургической операцией вводят во время вводного наркоза однократно 1 г. При необходимости, введение повторяют через 6-12 ч. При кесаревом сечении - в момент наложения зажимов на пупочную вену -внутривенно, 1 г, затем через 6 и 12 ч после первой дозы - дополнительно по 1 г.\u003Cbr\u003E\nПри клиренсе креатинина 20 мл/мин/1,73 м2 и менее, суточную дозу уменьшают в 2раза.\u003Cbr\u003E\nНедоношенным и новорожденным до 1 недели - внутривенно, 50 мг/кг каждые 12 ч; в возрасте 1-4 недели - внутривенно, 50 мг/кг каждые 8 ч; детям, массой тела до 50 кг -внутривенно или внутримышечно, 50-180 мг/кг в 4-6 введений. При тяжелом течении инфекций, в том числе при менингите, суточную дозу детям увеличивают до 100-200 мг/кг, внутримышечно или внутривенно, в 4-6 приемов, максимальная суточная доза- 12 г.\u003Cbr\u003E\nПравила приготовления инъекционных растворов:\u003Cbr\u003E\n- для внутривенной инъекции в качестве растворителя используют воду для инъекций (0,5-1 г разводят в 4 мл растворителя, 2 г - в 10 мл); препарат вводят медленно в течение 3-5 мин.\u003Cbr\u003E\n- для внутривенной инфузии в качестве растворителя используют 0,9 % раствор NaCl или 5 % раствор декстрозы (1-2 г разводят в 50-100 мл растворителя).\u003Cbr\u003EПродолжительность инфузии - 50-60 минут;\u003Cbr\u003E\n- для внутримышечного введения используют воду для инъекций или 1 % раствор лидокаина (для дозы препарата 0,5 г - 2 мл, для дозы 1 г - 4 мл)."},{"name":"Побочные действия","value":"Аллергические реакции: крапивница, озноб или лихорадка, сыпь, кожный зуд, редко - бронхоспазм, эозинофилия, злокачественная экссудативная эритема (синдром Стивенса-Джонсона), токсический эпидермальный некролиз (синдром Лайелла), ангионевротический отек, анафилактический шок.\u003Cbr\u003EСо стороны центральной нервной системы: головная боль, головокружение.\u003Cbr\u003EСо стороны мочевыделительной системы: нарушение функции почек, олигурия, интерстициальный нефрит.\u003Cbr\u003EСо стороны желудочно-кишечного тракта: тошнота, рвота, диарея или запоры, метеоризм, боль в животе, дисбактериоз, нарушение функции печени, редко - стоматит, глоссит, псевдомембранозный энтероколит.\u003Cbr\u003EСо стороны органов кроветворения: гемолитическая анемия, лейкопения, нейтропения, гранулоцитопения, тромбоцитопения, агранулоцитоз, гипокоагуляция.\u003Cbr\u003EСо стороны сердечно-сосудистой системы: потенциально жизнеопасные аритмии после быстрого болюсного введения в центральную вену.\u003Cbr\u003EЛабораторные показатели: азотемия, повышение концентрации мочевины в крови, повышение активности \"печеночных\" трансаминаз и щелочной фосфатазы, гиперкреатининемия, гипербилирубинемия, положительная реакция Кумбса.\u003Cbr\u003EМестные реакции: флебит, болезненность по ходу вены, болезненность и инфильтрат в месте внутримышечного введения.\u003Cbr\u003EПрочее: суперинфекция (в частности, вагинальный и оральный кандидоз)."},{"name":"Фармакологическое действие","value":"Действует бактерицидно, нарушая синтез мукопептида клеточной стенки микроорганизмов. Обладает широким спектром действия. Активен в отношении грамположительных и грамотрицательных микроорганизмов, устойчивых к другим антибиотикам: Staphylococcus spp. (в том числе Staphylococcus aureus, включая штаммы, образующие пенициллиназу), Staphylococcus epidermidis (за исключением Staphylococcus epidermidis и Staphylococcus aureus, устойчивых к метициллину), Streptococcus pneumoniae, Streptococcus pyogenes (бета-гемолитические стрептококки группы А), Streptococcus agalactiae (стрептококки группы В), Enterococcus spp., Enterobacter spp., Escherichia coli, Haemophilus influenzae (в том числе штаммы, образующие пенициллиназу), Haemophilus parainfluenzae, Moraxella catarrhalis, Klebsiella spp. (в том числе Klebsiella pneumoniae, Klebsiella oxytoca), Morganella morganii, Neisseria gonorrhoeae (в том числе штаммы, образующие пенициллиназу), Acinetobacter spp., Corynebacterium diphtheriae, Erysipelothrix rhusiopathiae, Eubacter spp., Propionibacterium spp., Clostridium spp. (в том числе Clostridium perfringens), Citrobacter spp., Proteus mirabilis, Proteus vulgaris, Providencia spp. (в том числе Providencia rettgeri), Serratia spp., некоторых штаммов Pseudomonas aeruginosa, Neisseria meningitidis, Neisseria gonorrhoeae, Bacteroides spp. (в том числе некоторые штаммы Bacteroides fragilis), Fusobacterium spp. (в том числе Fusobacterium nucleatum), Peptococcus spp., Peptostreptococcus spp. Непостоянно влияет на некоторые штаммы Pseudomonas aeruginosa, Acinetobacter, Helicobacter pylori, Bacteroides fragilis, Clostridium difficile. Устойчив к большинству бета-лактамаз грамположительных и грамотрицательных микроорганизмов."},{"name":"Фармакологическая группа","value":"антибиотики"},{"name":"Форма выпуска","value":"порошок для приготовления раствора для инъекций"},{"name":"Способ применения/введения","value":"парентеральный"},{"name":"Минимальный возраст применения","value":"от 12 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"В сухом, защищенном от света месте при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы: судороги, энцефалопатия (в случае введения больших доз, особенно у больных с почечной недостаточностью), тремор, нервно-мышечная возбудимость.\u003Cbr\u003EЛечение: симптоматическое, специфического антидота нет."},{"name":"Применение при беременности и кормлении грудью","value":"Беременность\u003Cbr /\u003EЦефотаксим проникает через плацентарный барьер. Исследования, проведенные на животных, не выявили тератогенного или фетотоксического действия препарата. Однако безопасность применения цефотаксима при беременности у человека не установлена, поэтому препарат не должен использоваться во время беременности.\u003Cbr /\u003EПериод грудного вскармливания\u003Cbr /\u003EЦефотаксим проникает в грудное молоко, поэтому при необходимости применения препарата грудное вскармливание следует прекратить."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В случае развития такого побочного эффекта как головокружение может нарушаться способность к концентрации внимания и реакциям. В таком случае пациентам следует воздержаться от вождения автотранспорта и работы с механизмами."},{"name":"Особые указания","value":"- в первые недели лечения может возникнуть псевдомембранозный колит, проявляющийся тяжелой длительной диареей. При этом прекращают прием препарата и назначают адекватную терапию, включая ванкомицин или метронидазол;\u003Cbr\u003E- пациенты, имевшие в анамнезе аллергические реакции на пенициллины, могут иметь повышенную чувствительность к цефалоспориновым антибиотикам;\u003Cbr\u003E- при лечении препаратом свыше 10 дней необходим контроль картины периферической крови. Во время лечения цефотаксимом возможно получение ложноположительной пробы Кумбса и ложноположительной реакции мочи на глюкозу;\u003Cbr\u003E- при необходимости назначения препарата в период лактации, следует прекратить грудное вскармливание;\u003Cbr\u003E- во время лечения нельзя употреблять этанол - возможны эффекты, сходные с действие дисульфирама (гиперемия лица, спазм в животе и в области желудка, тошнота, рвота, головная боль, снижение артериального давления, тахикардия, одышка)."},{"name":"Взаимодействие","value":"Цефотаксим, подавляя кишечную флору, препятствует синтезу витамина К. Поэтому при одновременном применении с препаратами, снижающими агрегацию тромбоцитов (НПВС, салицилаты, сульфинпиразон), увеличивается риск развития кровотечений. По этой же причине при одновременном применении с антикоагулянтами отмечается усиление антикоагулянтного действия.\u003Cbr\u003EПри одновременном применении с аминогликозидами, полимиксином B и \"петлевыми\" диуретиками повышается риск поражения почек.\u003Cbr\u003EПри одновременном применении с препаратами, уменьшающими канальцевую секрецию, повышается концентрация цефотаксима в плазме крови.\u003Cbr\u003EПробенецид замедляет выведение цефотаксима за счет снижения канальцевой секреции последнего."},{"name":"Источник","value":"\u003Ca href=\"https://www.vidal.ru\" target=\"_blank\"\u003EСправочник лекарственных препаратов Видаль<\u002Fa\u003E"},{"name":"Регистрационный номер","value":"ЛСР-008487/08"},{"name":"Дата государственной регистрации","value":"14.10.2019"},{"name":"Владелец регистрационного удостоверения","value":"ЛЕККО"},{"name":"Изготовитель","value":"ЛЕККО"},{"name":"Фасовщик","value":"ЛЕККО"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Цефотаксим"},{"name":"Срок годности","value":"574 дн."}]}],"transitionId":"tr_4764518793780077590"}}}}
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    Цена 36 ₽
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  • Цефотаксим пор. д/приг. р-ра для в/в и в/м введ., 1000 мг, 1 г, 1 шт.
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    Цефотаксим пор. д/приг. р-ра для в/в и в/м введ., 1000 мг, 1 г, 1 шт.

    Рейтинг товара: 3.5 из 5
    на основе 8 оценок
    Цена 35 ₽
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  • Цефотаксим пор. д/приг. р-ра для в/в и в/м введ., 1 г, 1 шт.
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    Цефотаксим пор. д/приг. р-ра для в/в и в/м введ., 1 г, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 37 ₽
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  • Клафоран пор. д/приг. р-ра для в/в и в/м введ., 1 г, 1 шт.
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    Клафоран пор. д/приг. р-ра для в/в и в/м введ., 1 г, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 176 ₽
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  • Цефиксим Экспресс таб. дисперг., 400 мг, 7 шт.
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    Цефиксим Экспресс таб. дисперг., 400 мг, 7 шт.

    Рейтинг товара: 4.7 из 5
    на основе 14 оценок
    Цена 683 ₽
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  • Клафоран пор. д/приг. р-ра для в/в и в/м введ., 1 г, 1 шт.
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    Клафоран пор. д/приг. р-ра для в/в и в/м введ., 1 г, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 187 ₽
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  • Зиннат таб. п/о плен., 250 мг, 10 шт.
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    Зиннат таб. п/о плен., 250 мг, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 11 оценок
    Цена 252 ₽
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  • Цефепим пор. д/приг. р-ра для в/в и в/м введ., 1 г, 1 шт.
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    Цефепим пор. д/приг. р-ра для в/в и в/м введ., 1 г, 1 шт.

    Рейтинг товара: 4.2 из 5
    на основе 10 оценок
    Цена 189 ₽
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  • Цефтриаксон пор. д/приг. р-ра для в/в и в/м введ. фл., 1 г, 1 шт.
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    Цефтриаксон пор. д/приг. р-ра для в/в и в/м введ. фл., 1 г, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 8 оценок
    Цена 74 ₽
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  • Сульцеф пор. д/приг. р-ра для в/в и в/м введ., 1 г+1 г, 2.18 г, 1 шт.
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    Сульцеф пор. д/приг. р-ра для в/в и в/м введ., 1 г+1 г, 2.18 г, 1 шт.

    Рейтинг товара: 3.5 из 5
    на основе 2 оценки
    Цена 413 ₽
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  • Цефазолин пор. д/приг. р-р для в/в введ. введ. и в/м фл., 1 г, 1 г, 1 шт.
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    Цефазолин пор. д/приг. р-р для в/в введ. введ. и в/м фл., 1 г, 1 г, 1 шт.

    Рейтинг товара: 4.8 из 5
    на основе 4 оценки
    Цена 47 ₽
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  • Цефазолин пор. д/приг. р-ра для в/в и в/м введ., 1 г, 1 г, 1 шт.
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    Цефазолин пор. д/приг. р-ра для в/в и в/м введ., 1 г, 1 г, 1 шт.

    Рейтинг товара: 4 из 5
    на основе 4 оценки
    Цена 68 ₽
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Инструкция

Показания к применению

Инфекционно-воспалительные заболевания тяжелого течения, вызванные чувствительными к цефотаксиму микроорганизмами, в т.ч. перитонит, сепсис, абдоминальные инфекции и инфекции органов малого таза, инфекции нижних отделов дыхательных путей, мочевыводящих путей, инфекции костей и суставов, кожи и мягких тканей, инфицированные раны и ожоги, гонорея, менингит, болезнь Лайма.
Профилактика инфекций после оперативного вмешательства.

Противопоказания

- Повышенная чувствительность к цефотаксиму и другим цефалоспоринам.
Для форм, содержащих в качестве растворителя лидокаин:
- повышенная чувствительность к лидокаину или другому местному анестетику амидного типа;
- внутрисердечные блокады без установленного водителя ритма;
- тяжелая сердечная недостаточность;
- внутривенное введение;
- детский возраст до 2,5 лет (для внутримышечного введения
С осторожностью:
- У пациентов, имеющих в анамнезе указания на аллергию к пенициллинам (риск развития перекрестных аллергических реакций);
- при одновременном применении с аминогликозидами;
- при почечной недостаточности.

Способ применения и дозы

Препарат вводят внутривенно (струйно или капельно) и внутримышечно.
Взрослым и детям старше 12 лет (с массой тела 50 кг и более): при неосложненных инфекциях, а также при инфекциях мочевыводящих путей - внутримышечно или внутривенно, по 1 г каждые 8-12 ч; при неосложненной острой гонорее - внутримышечно, 1 г однократно; при инфекциях средней тяжести - внутримышечно или внутривенно, по 1-2 г каждые 12 ч; при тяжелом течении инфекций, например при менингите - внутривенно, по 2 г каждые 4-8 ч, максимальная суточная доза - 12 г. Продолжительность лечения устанавливают индивидуально.
С целью профилактики развития инфекций перед хирургической операцией вводят во время вводного наркоза однократно 1 г. При необходимости, введение повторяют через 6-12 ч. При кесаревом сечении - в момент наложения зажимов на пупочную вену -внутривенно, 1 г, затем через 6 и 12 ч после первой дозы - дополнительно по 1 г.
При клиренсе креатинина 20 мл/мин/1,73 м2 и менее, суточную дозу уменьшают в 2раза.
Недоношенным и новорожденным до 1 недели - внутривенно, 50 мг/кг каждые 12 ч; в возрасте 1-4 недели - внутривенно, 50 мг/кг каждые 8 ч; детям, массой тела до 50 кг -внутривенно или внутримышечно, 50-180 мг/кг в 4-6 введений. При тяжелом течении инфекций, в том числе при менингите, суточную дозу детям увеличивают до 100-200 мг/кг, внутримышечно или внутривенно, в 4-6 приемов, максимальная суточная доза- 12 г.
Правила приготовления инъекционных растворов:
- для внутривенной инъекции в качестве растворителя используют воду для инъекций (0,5-1 г разводят в 4 мл растворителя, 2 г - в 10 мл); препарат вводят медленно в течение 3-5 мин.
- для внутривенной инфузии в качестве растворителя используют 0,9 % раствор NaCl или 5 % раствор декстрозы (1-2 г разводят в 50-100 мл растворителя).
Продолжительность инфузии - 50-60 минут;
- для внутримышечного введения используют воду для инъекций или 1 % раствор лидокаина (для дозы препарата 0,5 г - 2 мл, для дозы 1 г - 4 мл).
Полная инструкция
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Цефотаксим пор. д/приг. р-ра для в/в и в/м введ.
Цефотаксим пор. д/приг. р-ра для в/в и в/м введ., 1 г, 1 г, 1 шт.
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1 вопрос
Инструкция

43 ₽

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