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Описание

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Сульцеф пор. д/приг. р-ра для в/в и в/м введ., 1 г+1 г, 2.18 г, 1 шт.

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У продавца: 
нет • На Маркете: 3.5
(2)
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Коротко о товаре

Артикул Маркета
3123172684
Тип препарата
Назначение
бактериальные инфекции верхних отделов дыхательных путей и ЛОР-органов, бактериальные инфекции кожи и мягких тканей, бактериальные инфекции костной и соединительной ткани, бактериальные инфекции нижних отделов дыхательных путей, бактериальный менингит, гонорея, инфекции мочевыводящих путей, инфекции опорно-двигательного аппарата, инфекции органов малого таза, инфекционно-воспалительные заболевания, перитонит, септицемия, холангит, холецистит, эндометрит
Действующее вещество
Форма выпуска
порошок для приготовления раствора для инъекций
Инструкция
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препарат","transition":{"type":"catalog","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["34324371:35649313"]}}},{"name":"Рецептурный препарат","value":"да","transition":{"type":"catalog","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["27272850:1,0"]}}},{"name":"Назначение","value":"бактериальные инфекции верхних отделов дыхательных путей и ЛОР-органов, бактериальные инфекции кожи и мягких тканей, бактериальные инфекции костной и соединительной ткани, бактериальные инфекции нижних отделов дыхательных путей, бактериальный менингит, гонорея, инфекции мочевыводящих путей, инфекции опорно-двигательного аппарата, инфекции органов малого таза, инфекционно-воспалительные заболевания, перитонит, септицемия, холангит, холецистит, эндометрит","transition":{"type":"catalog","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["36476390:36618553,36618500,36618289,36618241,36618132,36618101,36618063,36617984,36617929,36617691,36617546,36617435,36617383,36617299,36617257"]}}},{"name":"Органы и системы","value":"выделительная система, дыхательная система, желчный пузырь и желчевыводящие пути, кожа, опорно-двигательная система, пищеварительная система, половая система"},{"name":"Показания к применению","value":"Инфекционно-воспалительные заболевания, вызванные чувствительными к цефоперазону/сульбактаму микроорганизмами.\u003Cbr\u003E- инфекции верхних и нижних дыхательных путей;\u003Cbr\u003E- инфекции мочевыводящих путей;\u003Cbr\u003E- интраабдоминальные инфекции (перитонит, холецистит, холангит);\u003Cbr\u003E- септицемия;\u003Cbr\u003E- менингит;\u003Cbr\u003E- инфекции кожи и мягких тканей;\u003Cbr\u003E- инфекции костей и суставов;\u003Cbr\u003E- инфекции мочеполового тракта (воспалительные заболевания органов малого таза, эндометрит, гонорея)."},{"name":"Противопоказания","value":"Повышенная чувствительность к пенициллинам, сульбактаму, цефоперазону в т.ч. к другим бета-лактамным антибиотикам.\u003Cbr\u003EС осторожностью:\u003Cbr\u003EТяжелые нарушения функции почек и печени, колит (в т.ч. в анамнезе), недоношенные новорожденные."},{"name":"Состав","value":"1 флакон содержит активные вещества:\u003Cbr\u003EЦефоперазон натрия эквивалентный 1,0 г цефоперазона\u003Cbr\u003EСульбактам натрия эквивалентный 1,0 г сульбактама."},{"name":"Действующее вещество","value":"Цефоперазон+Сульбактам","transition":{"type":"catalog","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["27144131:36090329"]}}},{"name":"Способ применения и дозы","value":"Внутривенно или внутримышечно.\u003Cbr\u003EВзрослым - по 2-4 г/сут с интервалом в 12 ч; при тяжелых, упорно протекающих инфекциях - по 8 г/сут. Максимальная суточная доза - 8 г.\u003Cbr\u003EБольным с хронической почечной недостаточностью (ХПН) (клиренс креатинина (КК) менее 30 мл/мин) - коррекция дозы: КК 15-30 мл/мин - по 1 г 2 раза в сутки, КК менее 14 мл/мин - по 500 мг 2 раза в сутки.\u003Cbr\u003EИзменение дозы может потребоваться в случае тяжелой обструкции желчных путей, тяжелых заболеваний печени. У больных с нарушением функции печени и сопутствующим нарушением функции почек необходимо мониторирование сывороточной концентрации цефоперазона и корреляция его дозы в случае необходимости. Если регулярное мониторирование сывороточной концентрации цефоперазона в таких случаях не проводится, то его суточная доза не должна превышать 2 г.\u003Cbr\u003EДетям - 40-80 мг/кг/сут в 2-4 введения; при тяжелых, длительно протекающих инфекциях -по 160 мг/кг/сут. Максимальная суточная доза - 160 мг/кг/сут. При необходимости введения более 80 мг/кг/сут, рассчитанных по активности цефоперазона, увеличение дозы достигается за счет дополнительного введения цефоперазона.\u003Cbr\u003EНоворожденным в течение первой недели жизни препарат следует вводить каждые 12 ч.\u003Cbr\u003EДля внутривенного введения содержимое флакона растворяют в адекватном объеме 5% раствора декстрозы, 0,9% раствора хлорида натрия для инъекций или стерильной воды для инъекций, разводят до 20 мл тем же раствором и вводят в течение 15-60 мин; внутривенные инъекции - 3 мин; для внутримышечного введения для растворения используют стерильную воду для инъекций. Для получения концентрации цефоперазона 250 мг/мл и более разведение проводят в 2 этапа: стерильной водой, затем 2% раствором лидокаина до получения 0,5% раствора лидокаина."},{"name":"Побочные действия","value":"Сердечно-сосудистая система: снижение артериального давления.\u003Cbr\u003EЖелудочно-кишечный тракт: диарея, тошнота, рвота, псевдомембранозный колит.\u003Cbr\u003EАллергические реакции: макулопапулезная сыпь, крапивница, зуд, синдром Стивенса-Джонсона, анафилактический шок. Риск реакций выше у больных с аллергическими реакциями в анамнезе.\u003Cbr\u003EСистема кроветворения: снижение числа нейтрофилов. При длительном лечении развивается обратимая нейтропения, отмечается снижение содержания гемоглобина и гематокрита, преходящая эозинофилия, лейкопения, тромбоцитопения, а также гипопротромбинемия, гиперкреатининемия, анемия, кровотечения.\u003Cbr\u003EЛабораторные показатели: повышение активности \"печеночных\" трансаминаз - аспартатаминотрансферазы (ACT), аланинаминотрансферазы (АЛТ), щелочной фосфатазы, билирубина в сыворотки крови, гематурия. У некоторых пациентов во время лечения наблюдалась ложноположительная проба Кумбса.\u003Cbr\u003EМестные реакции: после внутримышечной инъекции возможна преходящая боль. При внутривенном введении препарата с помощью катетера может развиться флебит в месте инфузии.\u003Cbr\u003EДругие: головная боль, лихорадка, озноб, васкулит."},{"name":"Фармакологическое действие","value":"Цефоперазон - цефалоспорин третьего поколения, который действует на чувствительные микроорганизмы во время их активного размножения путем угнетения биосинтеза мукопептида клеточной стенки.\u003Cbr\u003EСульбактам не обладает клинически значимой антибактериальной активностью (исключение составляют Neisseriaceae и Acinetobacter), является необратимым ингибитором большинства основных бета-лактамаз, которые продуцируют микроорганизмы, устойчивые к бета-лактамным антибиотикам. Сульбактам также связывается с некоторыми пенициллинсвязывающими белками, поэтому комбинация цефоперазона и сульбактама часто оказывает более выраженное действие на чувствительные штаммы, чем один цефоперазон.\u003Cbr\u003EКомбинация сульбактама и цефоперазона активна в отношении всех микроорганизмов, чувствительных к цефоперазону. Кроме того, она обладает синергизмом в отношении различных микроорганизмов, прежде всего: Haemophilus influenzae, Bacteroides spp., Staphylococcus spp., Acinetobacter calcoaceticus, Enterobacter aerogenes, Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Morganella morganii, Citrobacter freundii, Enterobacter cloacae, Citrobacter diversus.\u003Cbr\u003EАктивен in vitro в отношении широкого спектра клинически значимых микроорганизмов.\u003Cbr\u003EГрамположительные микроорганизмы:\u003Cbr\u003EStaphylococcus aureus (продуцирующие и не продуцирующие пенициллиназу), Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes (бета-гемолитический стрептококк группы A), Streptococcus agalactiae (бета-гемолитический стрептококк группы В), большинство других штаммов бета-гемолитических стрептококков, Streptococcus faecalis.\u003Cbr\u003EГрамотрицательные микроорганизмы:\u003Cbr\u003EKlebsiella spp., Enterobacter spp., Citrobacter spp., Proteus vulgaris, Providencia rettgeri, Providencia spp., Serratia spp. (включая S. marcescens), Salmonella spp., Shigella spp., Pseudomonas aeruginosa, Neisseria gonorrhoeae, Neisseria meningitidis; Bordetella pertussis, Yersinia enterocolitica.\u003Cbr\u003EАнаэробные микроорганизмы\u003Cbr\u003EBacteroides fragilis, Fusobacterium spp., Peptococcus spp., Peptostreptococcus spp., Veillonella spp., Clostridium spp., Eubacterium spp., Lactobacillus spp."},{"name":"Фармакологическая группа","value":"антибиотик-цефалоспорин+бета-лактамаз ингибитор"},{"name":"Форма выпуска","value":"порошок для приготовления раствора для инъекций"},{"name":"Способ применения/введения","value":"парентеральный","transition":{"type":"catalog","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["35947170:36763748"]}}},{"name":"Условия хранения","value":"Хранить в сухом, защищенном от света месте, при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы: неврологические нарушения, включая судороги.\u003Cbr\u003EЛечение: седативная терапия. Эффективен гемодиализ, особенно у больных с нарушенной функцией почек."},{"name":"Применение при беременности и кормлении грудью","value":"При беременности и в период грудного вскармливания препарат применяют только в том случае, если ожидаемая польза для матери превышает потенциальный риск для плода и новорожденного."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Препарат не влияет на способность управлять транспортными средствами и обслуживать механизмы."},{"name":"Особые указания","value":"При появлении аллергических реакций необходимо отменить препарат и назначить адекватную терапию.\u003Cbr\u003EПри лечении цефоперазоном в редких случаях развивается дефицит витамина К. Причиной его, вероятно, является подавление нормальной микрофлоры кишечника, которая синтезирует этот витамин. К группе риска можно отнести пациентов, получающих неполноценное питание, страдающих мальабсорбцией (например, при муковисцидозе) и длительно находящихся на внутривенном искусственном питании. В таких случаях, а также у больных, получающих антикоагулянты, необходимо контролировать протромбиновое время и при наличии показаний назначить витамин К. При длительном лечении возможен избыточный рост нечувствительных микроорганизмов. Больных необходимо тщательно наблюдать во время лечения.\u003Cbr\u003EПри длительной терапии рекомендуется периодически контролировать показатели функции внутренних органов, включая почки, печень и систему кроветворения. Это особенно важно при лечении новорожденных, прежде всего недоношенных, и маленьких детей.\u003Cbr\u003EПри одновременном использовании аминогликозидов необходимо контролировать функцию почек.\u003Cbr\u003EПри выраженной обструкции желчных путей, тяжелой печеночной недостаточности необходимо изменение дозы и контроль концентрации цефоперазона в сыворотке (максимальная суточная доза - 2 г).\u003Cbr\u003EЛечение недоношенных новорожденных проводится в том случае, если возможная польза превышает потенциальный риск.\u003Cbr\u003EВлияние на результаты лабораторных тестов\u003Cbr\u003EПри использовании раствора Бенедикта или Фелинга может наблюдаться ложноположительная реакция на глюкозу в моче. Возможна ложноположительная проба Кумбса."},{"name":"Взаимодействие","value":"Этанол\u003Cbr\u003EПри приеме алкоголя во время лечения препаратом и в течение последующих 5 дней после его введения были зарегистрированы дисульфирамоподобные реакции, характеризующиеся \"приливами\", потливостью, головной болью и тахикардией, поэтому пациентов следует предупреждать о возможности их появления при употреблении алкогольных напитков на фоне лечения препаратом. У больных, которым необходимо искусственное питание (внутрь или парентерально), следует избегать применения растворов, содержащих этанол.\u003Cbr\u003EАминогликозиды\u003Cbr\u003EРастворы препарата и аминогликозидов не следует смешивать, учитывая фармацевтическую несовместимость между ними. Если проводится комбинированная терапия препаратом и аминогликозидом, то два препарата вводят путем последовательных инфузий с использованием отдельных вторичных катетеров, а первичный катетер промывают адекватным раствором между введением доз препаратов. Интервалы между введением препарата и аминогликозида в течение дня должны быть как можно большими.\u003Cbr\u003EПетлевые диуретики\u003Cbr\u003EСовместное применение препарата с петлевыми диуретиками может привести к развитию нефротоксического действия.\u003Cbr\u003EСовместим с водой для инъекций, 5% раствором декстрозы, 0,9% раствором натрия хлорида, 5% раствором декстрозы в 0,225% растворе натрия хлорида, 5% раствором декстрозы в 0,9% растворе натрия хлорида. Несовместим с раствором Рингера, 2% раствором лидокаина (первоначальное использование воды для инъекций приводит к образованию совместимой смеси)."},{"name":"Регистрационный номер","value":"ЛС-001677"},{"name":"Дата государственной регистрации","value":"24.01.2013"},{"name":"Владелец регистрационного удостоверения","value":"Medochemie","transition":{"type":"catalog","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["34324371:35649313","7893318:16129914"]}}},{"name":"Изготовитель","value":"Medochemie"},{"name":"Фасовщик","value":"Medochemie"},{"name":"Страна бренда","value":"Кипр"},{"name":"Страна-производитель","value":"Кипр"},{"name":"Название препарата","value":"Сульцеф","transition":{"type":"catalog","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["17796364:18038409"]}}},{"name":"Срок годности","value":"2 г."}]}},"fullSpecsGrouped":{"18106349496690786599":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Назначение","value":"бактериальные инфекции верхних отделов дыхательных путей и ЛОР-органов, бактериальные инфекции кожи и мягких тканей, бактериальные инфекции костной и соединительной ткани, бактериальные инфекции нижних отделов дыхательных путей, бактериальный менингит, гонорея, инфекции мочевыводящих путей, инфекции опорно-двигательного аппарата, инфекции органов малого таза, инфекционно-воспалительные заболевания, перитонит, септицемия, холангит, холецистит, эндометрит"},{"name":"Органы и системы","value":"выделительная система, дыхательная система, желчный пузырь и желчевыводящие пути, кожа, опорно-двигательная система, пищеварительная система, половая система"},{"name":"Показания к применению","value":"Инфекционно-воспалительные заболевания, вызванные чувствительными к цефоперазону/сульбактаму микроорганизмами.\u003Cbr\u003E- инфекции верхних и нижних дыхательных путей;\u003Cbr\u003E- инфекции мочевыводящих путей;\u003Cbr\u003E- интраабдоминальные инфекции (перитонит, холецистит, холангит);\u003Cbr\u003E- септицемия;\u003Cbr\u003E- менингит;\u003Cbr\u003E- инфекции кожи и мягких тканей;\u003Cbr\u003E- инфекции костей и суставов;\u003Cbr\u003E- инфекции мочеполового тракта (воспалительные заболевания органов малого таза, эндометрит, гонорея)."},{"name":"Противопоказания","value":"Повышенная чувствительность к пенициллинам, сульбактаму, цефоперазону в т.ч. к другим бета-лактамным антибиотикам.\u003Cbr\u003EС осторожностью:\u003Cbr\u003EТяжелые нарушения функции почек и печени, колит (в т.ч. в анамнезе), недоношенные новорожденные."},{"name":"Состав","value":"1 флакон содержит активные вещества:\u003Cbr\u003EЦефоперазон натрия эквивалентный 1,0 г цефоперазона\u003Cbr\u003EСульбактам натрия эквивалентный 1,0 г сульбактама."},{"name":"Действующее вещество","value":"Цефоперазон+Сульбактам"},{"name":"Способ применения и дозы","value":"Внутривенно или внутримышечно.\u003Cbr\u003EВзрослым - по 2-4 г/сут с интервалом в 12 ч; при тяжелых, упорно протекающих инфекциях - по 8 г/сут. Максимальная суточная доза - 8 г.\u003Cbr\u003EБольным с хронической почечной недостаточностью (ХПН) (клиренс креатинина (КК) менее 30 мл/мин) - коррекция дозы: КК 15-30 мл/мин - по 1 г 2 раза в сутки, КК менее 14 мл/мин - по 500 мг 2 раза в сутки.\u003Cbr\u003EИзменение дозы может потребоваться в случае тяжелой обструкции желчных путей, тяжелых заболеваний печени. У больных с нарушением функции печени и сопутствующим нарушением функции почек необходимо мониторирование сывороточной концентрации цефоперазона и корреляция его дозы в случае необходимости. Если регулярное мониторирование сывороточной концентрации цефоперазона в таких случаях не проводится, то его суточная доза не должна превышать 2 г.\u003Cbr\u003EДетям - 40-80 мг/кг/сут в 2-4 введения; при тяжелых, длительно протекающих инфекциях -по 160 мг/кг/сут. Максимальная суточная доза - 160 мг/кг/сут. При необходимости введения более 80 мг/кг/сут, рассчитанных по активности цефоперазона, увеличение дозы достигается за счет дополнительного введения цефоперазона.\u003Cbr\u003EНоворожденным в течение первой недели жизни препарат следует вводить каждые 12 ч.\u003Cbr\u003EДля внутривенного введения содержимое флакона растворяют в адекватном объеме 5% раствора декстрозы, 0,9% раствора хлорида натрия для инъекций или стерильной воды для инъекций, разводят до 20 мл тем же раствором и вводят в течение 15-60 мин; внутривенные инъекции - 3 мин; для внутримышечного введения для растворения используют стерильную воду для инъекций. Для получения концентрации цефоперазона 250 мг/мл и более разведение проводят в 2 этапа: стерильной водой, затем 2% раствором лидокаина до получения 0,5% раствора лидокаина."},{"name":"Побочные действия","value":"Сердечно-сосудистая система: снижение артериального давления.\u003Cbr\u003EЖелудочно-кишечный тракт: диарея, тошнота, рвота, псевдомембранозный колит.\u003Cbr\u003EАллергические реакции: макулопапулезная сыпь, крапивница, зуд, синдром Стивенса-Джонсона, анафилактический шок. Риск реакций выше у больных с аллергическими реакциями в анамнезе.\u003Cbr\u003EСистема кроветворения: снижение числа нейтрофилов. При длительном лечении развивается обратимая нейтропения, отмечается снижение содержания гемоглобина и гематокрита, преходящая эозинофилия, лейкопения, тромбоцитопения, а также гипопротромбинемия, гиперкреатининемия, анемия, кровотечения.\u003Cbr\u003EЛабораторные показатели: повышение активности \"печеночных\" трансаминаз - аспартатаминотрансферазы (ACT), аланинаминотрансферазы (АЛТ), щелочной фосфатазы, билирубина в сыворотки крови, гематурия. У некоторых пациентов во время лечения наблюдалась ложноположительная проба Кумбса.\u003Cbr\u003EМестные реакции: после внутримышечной инъекции возможна преходящая боль. При внутривенном введении препарата с помощью катетера может развиться флебит в месте инфузии.\u003Cbr\u003EДругие: головная боль, лихорадка, озноб, васкулит."},{"name":"Фармакологическое действие","value":"Цефоперазон - цефалоспорин третьего поколения, который действует на чувствительные микроорганизмы во время их активного размножения путем угнетения биосинтеза мукопептида клеточной стенки.\u003Cbr\u003EСульбактам не обладает клинически значимой антибактериальной активностью (исключение составляют Neisseriaceae и Acinetobacter), является необратимым ингибитором большинства основных бета-лактамаз, которые продуцируют микроорганизмы, устойчивые к бета-лактамным антибиотикам. Сульбактам также связывается с некоторыми пенициллинсвязывающими белками, поэтому комбинация цефоперазона и сульбактама часто оказывает более выраженное действие на чувствительные штаммы, чем один цефоперазон.\u003Cbr\u003EКомбинация сульбактама и цефоперазона активна в отношении всех микроорганизмов, чувствительных к цефоперазону. Кроме того, она обладает синергизмом в отношении различных микроорганизмов, прежде всего: Haemophilus influenzae, Bacteroides spp., Staphylococcus spp., Acinetobacter calcoaceticus, Enterobacter aerogenes, Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Morganella morganii, Citrobacter freundii, Enterobacter cloacae, Citrobacter diversus.\u003Cbr\u003EАктивен in vitro в отношении широкого спектра клинически значимых микроорганизмов.\u003Cbr\u003EГрамположительные микроорганизмы:\u003Cbr\u003EStaphylococcus aureus (продуцирующие и не продуцирующие пенициллиназу), Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes (бета-гемолитический стрептококк группы A), Streptococcus agalactiae (бета-гемолитический стрептококк группы В), большинство других штаммов бета-гемолитических стрептококков, Streptococcus faecalis.\u003Cbr\u003EГрамотрицательные микроорганизмы:\u003Cbr\u003EKlebsiella spp., Enterobacter spp., Citrobacter spp., Proteus vulgaris, Providencia rettgeri, Providencia spp., Serratia spp. (включая S. marcescens), Salmonella spp., Shigella spp., Pseudomonas aeruginosa, Neisseria gonorrhoeae, Neisseria meningitidis; Bordetella pertussis, Yersinia enterocolitica.\u003Cbr\u003EАнаэробные микроорганизмы\u003Cbr\u003EBacteroides fragilis, Fusobacterium spp., Peptococcus spp., Peptostreptococcus spp., Veillonella spp., Clostridium spp., Eubacterium spp., Lactobacillus spp."},{"name":"Фармакологическая группа","value":"антибиотик-цефалоспорин+бета-лактамаз ингибитор"},{"name":"Форма выпуска","value":"порошок для приготовления раствора для инъекций"},{"name":"Способ применения/введения","value":"парентеральный"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Хранить в сухом, защищенном от света месте, при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы: неврологические нарушения, включая судороги.\u003Cbr\u003EЛечение: седативная терапия. Эффективен гемодиализ, особенно у больных с нарушенной функцией почек."},{"name":"Применение при беременности и кормлении грудью","value":"При беременности и в период грудного вскармливания препарат применяют только в том случае, если ожидаемая польза для матери превышает потенциальный риск для плода и новорожденного."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Препарат не влияет на способность управлять транспортными средствами и обслуживать механизмы."},{"name":"Особые указания","value":"При появлении аллергических реакций необходимо отменить препарат и назначить адекватную терапию.\u003Cbr\u003EПри лечении цефоперазоном в редких случаях развивается дефицит витамина К. Причиной его, вероятно, является подавление нормальной микрофлоры кишечника, которая синтезирует этот витамин. К группе риска можно отнести пациентов, получающих неполноценное питание, страдающих мальабсорбцией (например, при муковисцидозе) и длительно находящихся на внутривенном искусственном питании. В таких случаях, а также у больных, получающих антикоагулянты, необходимо контролировать протромбиновое время и при наличии показаний назначить витамин К. При длительном лечении возможен избыточный рост нечувствительных микроорганизмов. Больных необходимо тщательно наблюдать во время лечения.\u003Cbr\u003EПри длительной терапии рекомендуется периодически контролировать показатели функции внутренних органов, включая почки, печень и систему кроветворения. Это особенно важно при лечении новорожденных, прежде всего недоношенных, и маленьких детей.\u003Cbr\u003EПри одновременном использовании аминогликозидов необходимо контролировать функцию почек.\u003Cbr\u003EПри выраженной обструкции желчных путей, тяжелой печеночной недостаточности необходимо изменение дозы и контроль концентрации цефоперазона в сыворотке (максимальная суточная доза - 2 г).\u003Cbr\u003EЛечение недоношенных новорожденных проводится в том случае, если возможная польза превышает потенциальный риск.\u003Cbr\u003EВлияние на результаты лабораторных тестов\u003Cbr\u003EПри использовании раствора Бенедикта или Фелинга может наблюдаться ложноположительная реакция на глюкозу в моче. Возможна ложноположительная проба Кумбса."},{"name":"Взаимодействие","value":"Этанол\u003Cbr\u003EПри приеме алкоголя во время лечения препаратом и в течение последующих 5 дней после его введения были зарегистрированы дисульфирамоподобные реакции, характеризующиеся \"приливами\", потливостью, головной болью и тахикардией, поэтому пациентов следует предупреждать о возможности их появления при употреблении алкогольных напитков на фоне лечения препаратом. У больных, которым необходимо искусственное питание (внутрь или парентерально), следует избегать применения растворов, содержащих этанол.\u003Cbr\u003EАминогликозиды\u003Cbr\u003EРастворы препарата и аминогликозидов не следует смешивать, учитывая фармацевтическую несовместимость между ними. Если проводится комбинированная терапия препаратом и аминогликозидом, то два препарата вводят путем последовательных инфузий с использованием отдельных вторичных катетеров, а первичный катетер промывают адекватным раствором между введением доз препаратов. Интервалы между введением препарата и аминогликозида в течение дня должны быть как можно большими.\u003Cbr\u003EПетлевые диуретики\u003Cbr\u003EСовместное применение препарата с петлевыми диуретиками может привести к развитию нефротоксического действия.\u003Cbr\u003EСовместим с водой для инъекций, 5% раствором декстрозы, 0,9% раствором натрия хлорида, 5% раствором декстрозы в 0,225% растворе натрия хлорида, 5% раствором декстрозы в 0,9% растворе натрия хлорида. Несовместим с раствором Рингера, 2% раствором лидокаина (первоначальное использование воды для инъекций приводит к образованию совместимой смеси)."},{"name":"Регистрационный номер","value":"ЛС-001677"},{"name":"Дата государственной регистрации","value":"24.01.2013"},{"name":"Владелец регистрационного удостоверения","value":"Medochemie"},{"name":"Изготовитель","value":"Medochemie"},{"name":"Фасовщик","value":"Medochemie"},{"name":"Страна бренда","value":"Кипр"},{"name":"Страна-производитель","value":"Кипр"},{"name":"Название препарата","value":"Сульцеф"},{"name":"Срок годности","value":"2 г."}]}],"transitionId":"tr_2829708109298581493"}}}}
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    на основе 7 оценок
    Цена 200 ₽
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  • Цефазолин пор. д/приг. р-р для в/в введ. введ. и в/м фл., 1 г, 1 г, 1 шт.
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    Цефазолин пор. д/приг. р-р для в/в введ. введ. и в/м фл., 1 г, 1 г, 1 шт.

    Рейтинг товара: 4.8 из 5
    на основе 4 оценки
    Цена 47 ₽
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  • Клафоран пор. д/приг. р-ра для в/в и в/м введ., 1 г, 1 шт.
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    Клафоран пор. д/приг. р-ра для в/в и в/м введ., 1 г, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 187 ₽
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  • Ванкомицин пор. д/приг. р-ра д/инф. и приема внутрь, 1 г, 1 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-67hjl5meny4/toggleWishlist":{"skuId":"227843694","productId":1434054481,"offerId":"l8got05FceWsRlAvifjaHA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQkPqV/cmfjMJVEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI0d7nqwUQ7rzSbBjM3tAHIPfcwQc=","sign":"ditTKBFY9NCGQizOj9axl2ZR393nl2jVBgVoNPyKY7A="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-67hjl5meny4/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Ванкомицин пор. д/приг. р-ра д/инф. и приема внутрь, 1 г, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 311 ₽
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  • Цефтриаксон пор. д/приг. р-ра для в/в и в/м введ., 1 г, 1 шт.
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    Цефтриаксон пор. д/приг. р-ра для в/в и в/м введ., 1 г, 1 шт.

    Рейтинг товара: 4.5 из 5
    на основе 4 оценки
    Цена 42 ₽
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  • Цефотаксим пор. д/приг. р-ра для в/в и в/м введ., 1 г, 1 г, 1 шт.
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    Цефотаксим пор. д/приг. р-ра для в/в и в/м введ., 1 г, 1 г, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 43 ₽
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  • Цефтриаксон пор. д/приг. р-ра для в/в и в/м введ. фл., 1 г, 1 шт.
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    Цефтриаксон пор. д/приг. р-ра для в/в и в/м введ. фл., 1 г, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 18 оценок
    Цена 42 ₽
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  • Бициллин-5 пор. д/приг. сусп. для в/м введ., 1200000 ЕД+300000 ЕД, 1 шт.
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    Бициллин-5 пор. д/приг. сусп. для в/м введ., 1200000 ЕД+300000 ЕД, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 9 оценок
    Цена 250 ₽
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  • Флуимуцил-антибиотик ИТ лиоф. д/приг. р-ра д/ин. и инг., 500 мг, 3 шт.
    –11 %
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    Флуимуцил-антибиотик ИТ лиоф. д/приг. р-ра д/ин. и инг., 500 мг, 3 шт.

    Рейтинг товара: 5 из 5
    на основе 47 оценок
    Цена 3 664 ₽ вместо 4 117
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  • Цефотаксим пор. д/приг. р-ра для в/в и в/м введ., 1 г, 1 шт.
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    Цефотаксим пор. д/приг. р-ра для в/в и в/м введ., 1 г, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 37 ₽
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  • Альфа Нормикс таб. п/о плен., 200 мг, 12 шт.
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    Альфа Нормикс таб. п/о плен., 200 мг, 12 шт.

    Рейтинг товара: 4.8 из 5
    на основе 59 оценок
    Цена 986 ₽
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Инструкция

Показания к применению

Инфекционно-воспалительные заболевания, вызванные чувствительными к цефоперазону/сульбактаму микроорганизмами.
- инфекции верхних и нижних дыхательных путей;
- инфекции мочевыводящих путей;
- интраабдоминальные инфекции (перитонит, холецистит, холангит);
- септицемия;
- менингит;
- инфекции кожи и мягких тканей;
- инфекции костей и суставов;
- инфекции мочеполового тракта (воспалительные заболевания органов малого таза, эндометрит, гонорея).

Противопоказания

Повышенная чувствительность к пенициллинам, сульбактаму, цефоперазону в т.ч. к другим бета-лактамным антибиотикам.
С осторожностью:
Тяжелые нарушения функции почек и печени, колит (в т.ч. в анамнезе), недоношенные новорожденные.

Способ применения и дозы

Внутривенно или внутримышечно.
Взрослым - по 2-4 г/сут с интервалом в 12 ч; при тяжелых, упорно протекающих инфекциях - по 8 г/сут. Максимальная суточная доза - 8 г.
Больным с хронической почечной недостаточностью (ХПН) (клиренс креатинина (КК) менее 30 мл/мин) - коррекция дозы: КК 15-30 мл/мин - по 1 г 2 раза в сутки, КК менее 14 мл/мин - по 500 мг 2 раза в сутки.
Изменение дозы может потребоваться в случае тяжелой обструкции желчных путей, тяжелых заболеваний печени. У больных с нарушением функции печени и сопутствующим нарушением функции почек необходимо мониторирование сывороточной концентрации цефоперазона и корреляция его дозы в случае необходимости. Если регулярное мониторирование сывороточной концентрации цефоперазона в таких случаях не проводится, то его суточная доза не должна превышать 2 г.
Детям - 40-80 мг/кг/сут в 2-4 введения; при тяжелых, длительно протекающих инфекциях -по 160 мг/кг/сут. Максимальная суточная доза - 160 мг/кг/сут. При необходимости введения более 80 мг/кг/сут, рассчитанных по активности цефоперазона, увеличение дозы достигается за счет дополнительного введения цефоперазона.
Новорожденным в течение первой недели жизни препарат следует вводить каждые 12 ч.
Для внутривенного введения содержимое флакона растворяют в адекватном объеме 5% раствора декстрозы, 0,9% раствора хлорида натрия для инъекций или стерильной воды для инъекций, разводят до 20 мл тем же раствором и вводят в течение 15-60 мин; внутривенные инъекции - 3 мин; для внутримышечного введения для растворения используют стерильную воду для инъекций. Для получения концентрации цефоперазона 250 мг/мл и более разведение проводят в 2 этапа: стерильной водой, затем 2% раствором лидокаина до получения 0,5% раствора лидокаина.
Полная инструкция
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Сульцеф пор. д/приг. р-ра для в/в и в/м введ.
Сульцеф пор. д/приг. р-ра для в/в и в/м введ., 1 г+1 г, 2.18 г, 1 шт.
У продавца: 
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