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Описание

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Антистен МВ таб. пролонг. высвоб. п/о плен., 35 мг, 60 шт., 1

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Коротко о товаре

Артикул Маркета
3123168299
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
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Внутрь, по 1 таблетке 2 раза в сутки, утром и вечером, во время еды. Оценка пользы от лечения должна быть проведена после трех месяцев приема препарата. Прием триметазидина следует прекратить, если за это время улучшение не наступило. Продолжительность лечения определяется врачом.\u003Cbr\u003EОсобые группы.Пациенты с нарушением функции почек. У пациентов с умеренным нарушением функции почек (КК 30-60 мл/мин) суточная доза составляет 35 мг (1 таблетка), утром во время завтрака.\u003Cbr\u003EПациенты пожилого возраста. У пациентов пожилого возраста может наблюдаться повышенная экспозиция триметазидина из-за возрастного снижения функции почек, У пациентов с умеренным нарушением функции почек (КК 30-60 мл/мин) рекомендованная суточная доза составляет 35 мг (1 таблетка), утром во время завтрака. Подбор дозы у пациентов старше 75 лет должен происходить с осторожностью."},{"name":"Побочные действия","value":"Нежелательные реакции, определенные как нежелательные явления, имеющие, по крайней мере, возможное отношение к лечению триметазидином, приведены в следующей градации: очень часто (\u003E1/10), часто (\u003E1/100, \u003C1/10), нечасто (\u003E1/1000, \u003C1/100), редко (\u003E1/10000, \u003C1/1000), очень редко (\u003C1/10000), неуточненной частоты (частота не может быть подсчитана по доступным данным).\u003Cbr\u003EНарушения со стороны крови и лимфатической системы: агранулоцитоз -, тромбоцитопения,тромбоцитопеническая пурпура - неуточненной частоты;\u003Cbr\u003EНарушение со стороны нервной системы: головокружение, головная боль - часто; симптомы паркинсонизма (тремор, акинезия, повышение тонуса), неустойчивость походки, синдром «беспокойных ног», другие связанные с ними двигательные нарушения, обычно обратимые после прекращения терапии; нарушения сна (бессонница, сонливость) - неуточненной частоты; \u003Cbr\u003EНарушения со стороны органа слуха и лабиринтные нарушения: вертиго - неуточненной частоты; \u003Cbr\u003EНарушения со стороны сердца: ощущения сердцебиения, экстрасистолия, тахикардия;\u003Cbr\u003EНарушения со стороны сосудов: артериальная гипотензия, ортостатическая гипотензия, которая может сопровождаться общим недомоганием головокружением или падением, особенно при одновременном приеме гипотензивных препаратов; приливы крови к коже лица-редко;\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта: боль в животе: часто-диарея, диспепсия, тошнота, рвота; запор - неуточненной частоты;\u003Cbr\u003EНарушения со стороны печени и желчевыводящих путей: гепатит-неуточненной частоты;\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей: кожная сыпь, кожный зуд, крапивница - часто; острый генерализованный экзантематозный пустулез, ангионевротический отек - неуточненной частоты;\u003Cbr\u003EОбщие расстройства и нарушения в месте ведения: астения – часто."},{"name":"Фармакологическое действие","value":"Триметазидин предотвращает снижение внутриклеточной концентрации аденозинтрифосфата (АТФ) путем сохранения энергетического метаболизма клеток в состоянии гипоксии. Таким образом, препарат обеспечивает нормальное функционирование мембранных ионных каналов, трансмембранный перенос ионов калия и натрия и сохранение клеточного гомеостаза. Триметазидин ингибирует окисление жирных кислот за счет селективного ингибирования фермента 3-кетоацил-КоА-тиолазы (3-КАТ) митохондриальной длинноцепочечной изоформы жирных кислот, что приводит к усилению окисления глюкозы и ускорению гликолиза с окислением глюкозы, что и обусловливает защиту миокарда от ишемии. Переключение энергетического метаболизма с окисления жирных кислот на окисление глюкозы лежит в основе фармакологических свойств триметазидина.\u003Cbr\u003EФармакодинамические свойства:\u003Cbr\u003E-поддерживает энергетический метаболизм сердца и нейросенсорных тканей во время ишемии;\u003Cbr\u003E-уменьшает выраженность внутриклеточного ацидоза и изменений трансмембранного ионного потока, возникающих при ишемии;\u003Cbr\u003E-понижает уровень миграции и инфильтрации полинуклеарных нейтрофилов в -ишемизированных и реперфузированных тканях сердца;\u003Cbr\u003E-уменьшает размер повреждения миокарда;\u003Cbr\u003E-не оказывает прямого воздействия на показатели гемодинамики.\u003Cbr\u003EУ пациентов со стенокардией триметазидин:\u003Cbr\u003E-увеличивает коронарный резерв, тем самым замедляя наступление ишемии, вызванной физической нагрузкой, начиная с 15-го дня терапии;\u003Cbr\u003E-ограничивает колебания артериального давления, вызванные физической нагрузкой, без значительных изменений частоты сердечных сокращений;\u003Cbr\u003E-значительно снижает частоту приступов стенокардии и потребность в приеме нитроглицерина короткого действия;\u003Cbr\u003E-улучшает сократительную функцию левого желудочка у пациентов с ишемической дисфункцией.\u003Cbr\u003EРезультаты проведенных клинических исследований подтвердили эффективность и безопасность применения триметазидина у пациентов со стабильной стенокардией как в монотерапии, так и в составе комбинированной терапии при недостаточном эффекте других антиангинальных препаратов.\u003Cbr\u003EВ исследовании с участием 426 пациентов со стабильной стенокардией (TRIMPOL-II) добавление триметазидина (60 мг/сут) к терапии метопрололом 100 мг/сут (50 мг 2 раза в сутки) в течение 12 недель статистически достоверно улучшило результаты нагрузочных тестов и клинические симптомы по сравнению с плацебо: общую длительность нагрузочных тестов, общее время выполнения нагрузки, время до развития депрессии сегмента ST на 1 мм, время до развития приступа стенокардии, количество приступов стенокардии в неделю и потребление нитратов короткого действия в неделю, без гемодинамических изменений. В исследовании с участием 223 пациентов со стабильной стенокардией (Sellier) добавление триметазидина в дозе 35 мг (2 раза/сутки) к терапии атенололом в дозе 50 мг (1 раз в сутки) в течение 8 недель приводило к увеличению времени до развития ишемической депрессии сегмента ST на 1 мм при проведении нагрузочных тестов в подгруппе пациентов по сравнению с плацебо. Существенная разница также была показана для времени развития приступов стенокардии. Не выявлено достоверных различий между группами для других вторичных конечных точек (общая длительность нагрузочных тестов, общее время нагрузки и клинические конечные точки). В исследовании с участием 1962 пациентов со стабильной стенокардией (Vasco) триметазидин (70 мг/сут и 140 мг/сут) в сравнении с плацебо был добавлен к терапии атенололом 50 мг/сут. В общей популяции, включая пациентов как без симптомов, так и с симптомами стенокардии, триметазидин не продемонстрировал преимуществ по эргометрическим и клиническим конечным точкам. Однако в ретроспективном анализе в подгруппе пациентов с симптомами стенокардии триметазидин (140 мг) значительно улучшил общее время нагрузочного теста и время до развития приступа стенокардии."},{"name":"Фармакологическая группа","value":"антигипоксантное средство"},{"name":"Форма выпуска","value":"таблетки с пролонгированным высвобождением"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"Хранить при температуре не выше 25 °C. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Имеется лишь очень ограниченная информация о передозировке триметазидина. В случае передозировки следует проводить симптоматическую терапию."},{"name":"Применение при беременности и кормлении грудью","value":"Беременность. Данные о применении триметазидина у беременных отсутствуют. Исследования на животных не выявили наличие прямого или непрямого негативного влияния в отношении репродуктивной функции. Применение лекарственного препарата Антистен МВ во время беременности противопоказано.\u003Cbr\u003EПериод грудного вскармливания. Данные о выделении триметазидина или его метаболитов в грудное молоко отсутствуют. Риск для новорожденного/ребенка не может быть исключен. При необходимости применения лекарственного препарата Антистен МВ в период лактации грудное вскармливание необходимо прекратить.\u003Cbr\u003EФертильность. Исследования репродуктивной токсичности не выявили влияния препарата на самцов и самок крыс."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В ходе клинических исследований не было выявлено влияния триметазидина на показатели гемодинамики, однако в период пострегистрационного применения наблюдались случаи головокружения и сонливости, что может повлиять на способность к управлению автотранспортом и выполнение работ, требующих повышенной скорости физической и психической реакций."},{"name":"Особые указания","value":"Лекарственный препарат Антистен МВ не предназначен для купирования приступов стенокардии и не показан для начального курса терапии нестабильной стенокардии или инфаркта миокарда на догоспитальном этапе или в первые дни госпитализации. В случае развития приступа стенокардии следует вновь оценить степень поражения коронарных артерий и, при необходимости, адаптировать лечение (лекарственную терапию или возможное проведение процедуры реваскуляризации). \u003Cbr\u003EТриметазидин может вызывать или ухудшать симптомы паркинсонизма (тремор, акинезию, повышение тонуса), поэтому следует проводить регулярное наблюдение пациентов, особенно пожилого возраста. В сомнительных случаях пациенты должны быть направлены к неврологу для соответствующего обследования. \u003Cbr\u003EПри появлении двигательных нарушений, таких как симптомы паркинсонизма, синдром «беспокойных ног», тремор, неустойчивость походки, триметазидин следует окончательно отменить. Такие случаи редки и симптомы обычно проходят после прекращения терапии: у большинства пациентов - в течение 4 месяцев после отмены триметазидина. \u003Cbr\u003EЕсли симптомы паркинсонизма сохраняются более 4 месяцев после отмены препарата, следует проконсультироваться у невролога. Могут отмечаться случаи падения, связанные с неустойчивостью походки или артериальной гипотензией, особенно у пациентов, принимающих гипотензивные препараты. Следует с осторожностью назначать триметазидин пациентам, у которых возможно повышение его экспозиции: При нарушении функции почек умеренной степени тяжести. У пожилых пациентов старше 75 лет."},{"name":"Взаимодействие","value":"Не было выявлено взаимодействий с другими лекарственными средствами."},{"name":"Регистрационный номер","value":"ЛСР-008140/10"},{"name":"Дата государственной регистрации","value":"27.01.2021"},{"name":"Владелец регистрационного удостоверения","value":"ОЗОН Фармацевтика","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["34324371:35649313","7893318:13891799"]}}},{"name":"Изготовитель","value":"ОЗОН"},{"name":"Фасовщик","value":"ОЗОН"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Антистен МВ","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["17796364:18003837"]}}},{"name":"Срок годности","value":"35 мес."}]}},"fullSpecsGrouped":{"3145963184471244958":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"кровеносные сосуды, сердце"},{"name":"Назначение","value":"ишемическая болезнь сердца, профилактика приступов стенокардии"},{"name":"Показания к применению","value":"Длительная терапия ишемической болезни сердца: профилактика приступов стабильной стенокардии в составе моно- или комбинированной терапии."},{"name":"Противопоказания","value":"Повышенная чувствительность к действующему веществу или любому из вспомогательных веществ, входящих в состав лекарственного препарата.\u003Cbr\u003EБолезнь Паркинсона, симптомы паркинсонизма, тремор, синдром «беспокойных ног» и другие, связанные с ними двигательные нарушения.\u003Cbr\u003EТяжелая почечная недостаточность (клиренс креатинина менее 30 мл/мин).\u003Cbr\u003EИз-за отсутствия достаточного количества клинических данных пациентам до 18 лет назначение лекарственного препарата не рекомендуется.\u003Cbr\u003EБеременность и период грудного вскармливания."},{"name":"Состав","value":"Действующее вещество: триметазидина дигидрохлорид - 35,000 мг.\u003Cbr\u003EВспомогательные вещества: целлюлоза микрокристаллическая (МКЦ-200) - 178,900 мг, гипромеллоза К15М - 46,500 мг, гипромеллоза К100М - 46,500 мг, кремния диоксид коллоидный - 1,550 мг, магния стеарат - 1,550 мг.\u003Cbr\u003EСостав оболочки: поливиниловый спирт - 4,000 мг, макрогол-4000 - 3,178 мг, титана диоксид - 2,760 мг, краситель железа оксид красный - 0,040 мг, краситель железа оксид желтый - 0,022 мг."},{"name":"Действующее вещество","value":"Триметазидин"},{"name":"Способ применения и дозы","value":"Таблетки следует принимать целиком, не разжевывая, запивая водой. Внутрь, по 1 таблетке 2 раза в сутки, утром и вечером, во время еды. Оценка пользы от лечения должна быть проведена после трех месяцев приема препарата. Прием триметазидина следует прекратить, если за это время улучшение не наступило. Продолжительность лечения определяется врачом.\u003Cbr\u003EОсобые группы.Пациенты с нарушением функции почек. У пациентов с умеренным нарушением функции почек (КК 30-60 мл/мин) суточная доза составляет 35 мг (1 таблетка), утром во время завтрака.\u003Cbr\u003EПациенты пожилого возраста. У пациентов пожилого возраста может наблюдаться повышенная экспозиция триметазидина из-за возрастного снижения функции почек, У пациентов с умеренным нарушением функции почек (КК 30-60 мл/мин) рекомендованная суточная доза составляет 35 мг (1 таблетка), утром во время завтрака. Подбор дозы у пациентов старше 75 лет должен происходить с осторожностью."},{"name":"Побочные действия","value":"Нежелательные реакции, определенные как нежелательные явления, имеющие, по крайней мере, возможное отношение к лечению триметазидином, приведены в следующей градации: очень часто (\u003E1/10), часто (\u003E1/100, \u003C1/10), нечасто (\u003E1/1000, \u003C1/100), редко (\u003E1/10000, \u003C1/1000), очень редко (\u003C1/10000), неуточненной частоты (частота не может быть подсчитана по доступным данным).\u003Cbr\u003EНарушения со стороны крови и лимфатической системы: агранулоцитоз -, тромбоцитопения,тромбоцитопеническая пурпура - неуточненной частоты;\u003Cbr\u003EНарушение со стороны нервной системы: головокружение, головная боль - часто; симптомы паркинсонизма (тремор, акинезия, повышение тонуса), неустойчивость походки, синдром «беспокойных ног», другие связанные с ними двигательные нарушения, обычно обратимые после прекращения терапии; нарушения сна (бессонница, сонливость) - неуточненной частоты; \u003Cbr\u003EНарушения со стороны органа слуха и лабиринтные нарушения: вертиго - неуточненной частоты; \u003Cbr\u003EНарушения со стороны сердца: ощущения сердцебиения, экстрасистолия, тахикардия;\u003Cbr\u003EНарушения со стороны сосудов: артериальная гипотензия, ортостатическая гипотензия, которая может сопровождаться общим недомоганием головокружением или падением, особенно при одновременном приеме гипотензивных препаратов; приливы крови к коже лица-редко;\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта: боль в животе: часто-диарея, диспепсия, тошнота, рвота; запор - неуточненной частоты;\u003Cbr\u003EНарушения со стороны печени и желчевыводящих путей: гепатит-неуточненной частоты;\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей: кожная сыпь, кожный зуд, крапивница - часто; острый генерализованный экзантематозный пустулез, ангионевротический отек - неуточненной частоты;\u003Cbr\u003EОбщие расстройства и нарушения в месте ведения: астения – часто."},{"name":"Фармакологическое действие","value":"Триметазидин предотвращает снижение внутриклеточной концентрации аденозинтрифосфата (АТФ) путем сохранения энергетического метаболизма клеток в состоянии гипоксии. Таким образом, препарат обеспечивает нормальное функционирование мембранных ионных каналов, трансмембранный перенос ионов калия и натрия и сохранение клеточного гомеостаза. Триметазидин ингибирует окисление жирных кислот за счет селективного ингибирования фермента 3-кетоацил-КоА-тиолазы (3-КАТ) митохондриальной длинноцепочечной изоформы жирных кислот, что приводит к усилению окисления глюкозы и ускорению гликолиза с окислением глюкозы, что и обусловливает защиту миокарда от ишемии. Переключение энергетического метаболизма с окисления жирных кислот на окисление глюкозы лежит в основе фармакологических свойств триметазидина.\u003Cbr\u003EФармакодинамические свойства:\u003Cbr\u003E-поддерживает энергетический метаболизм сердца и нейросенсорных тканей во время ишемии;\u003Cbr\u003E-уменьшает выраженность внутриклеточного ацидоза и изменений трансмембранного ионного потока, возникающих при ишемии;\u003Cbr\u003E-понижает уровень миграции и инфильтрации полинуклеарных нейтрофилов в -ишемизированных и реперфузированных тканях сердца;\u003Cbr\u003E-уменьшает размер повреждения миокарда;\u003Cbr\u003E-не оказывает прямого воздействия на показатели гемодинамики.\u003Cbr\u003EУ пациентов со стенокардией триметазидин:\u003Cbr\u003E-увеличивает коронарный резерв, тем самым замедляя наступление ишемии, вызванной физической нагрузкой, начиная с 15-го дня терапии;\u003Cbr\u003E-ограничивает колебания артериального давления, вызванные физической нагрузкой, без значительных изменений частоты сердечных сокращений;\u003Cbr\u003E-значительно снижает частоту приступов стенокардии и потребность в приеме нитроглицерина короткого действия;\u003Cbr\u003E-улучшает сократительную функцию левого желудочка у пациентов с ишемической дисфункцией.\u003Cbr\u003EРезультаты проведенных клинических исследований подтвердили эффективность и безопасность применения триметазидина у пациентов со стабильной стенокардией как в монотерапии, так и в составе комбинированной терапии при недостаточном эффекте других антиангинальных препаратов.\u003Cbr\u003EВ исследовании с участием 426 пациентов со стабильной стенокардией (TRIMPOL-II) добавление триметазидина (60 мг/сут) к терапии метопрололом 100 мг/сут (50 мг 2 раза в сутки) в течение 12 недель статистически достоверно улучшило результаты нагрузочных тестов и клинические симптомы по сравнению с плацебо: общую длительность нагрузочных тестов, общее время выполнения нагрузки, время до развития депрессии сегмента ST на 1 мм, время до развития приступа стенокардии, количество приступов стенокардии в неделю и потребление нитратов короткого действия в неделю, без гемодинамических изменений. В исследовании с участием 223 пациентов со стабильной стенокардией (Sellier) добавление триметазидина в дозе 35 мг (2 раза/сутки) к терапии атенололом в дозе 50 мг (1 раз в сутки) в течение 8 недель приводило к увеличению времени до развития ишемической депрессии сегмента ST на 1 мм при проведении нагрузочных тестов в подгруппе пациентов по сравнению с плацебо. Существенная разница также была показана для времени развития приступов стенокардии. Не выявлено достоверных различий между группами для других вторичных конечных точек (общая длительность нагрузочных тестов, общее время нагрузки и клинические конечные точки). В исследовании с участием 1962 пациентов со стабильной стенокардией (Vasco) триметазидин (70 мг/сут и 140 мг/сут) в сравнении с плацебо был добавлен к терапии атенололом 50 мг/сут. В общей популяции, включая пациентов как без симптомов, так и с симптомами стенокардии, триметазидин не продемонстрировал преимуществ по эргометрическим и клиническим конечным точкам. Однако в ретроспективном анализе в подгруппе пациентов с симптомами стенокардии триметазидин (140 мг) значительно улучшил общее время нагрузочного теста и время до развития приступа стенокардии."},{"name":"Фармакологическая группа","value":"антигипоксантное средство"},{"name":"Форма выпуска","value":"таблетки с пролонгированным высвобождением"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Хранить при температуре не выше 25 °C. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Имеется лишь очень ограниченная информация о передозировке триметазидина. В случае передозировки следует проводить симптоматическую терапию."},{"name":"Применение при беременности и кормлении грудью","value":"Беременность. Данные о применении триметазидина у беременных отсутствуют. Исследования на животных не выявили наличие прямого или непрямого негативного влияния в отношении репродуктивной функции. Применение лекарственного препарата Антистен МВ во время беременности противопоказано.\u003Cbr\u003EПериод грудного вскармливания. Данные о выделении триметазидина или его метаболитов в грудное молоко отсутствуют. Риск для новорожденного/ребенка не может быть исключен. При необходимости применения лекарственного препарата Антистен МВ в период лактации грудное вскармливание необходимо прекратить.\u003Cbr\u003EФертильность. Исследования репродуктивной токсичности не выявили влияния препарата на самцов и самок крыс."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В ходе клинических исследований не было выявлено влияния триметазидина на показатели гемодинамики, однако в период пострегистрационного применения наблюдались случаи головокружения и сонливости, что может повлиять на способность к управлению автотранспортом и выполнение работ, требующих повышенной скорости физической и психической реакций."},{"name":"Особые указания","value":"Лекарственный препарат Антистен МВ не предназначен для купирования приступов стенокардии и не показан для начального курса терапии нестабильной стенокардии или инфаркта миокарда на догоспитальном этапе или в первые дни госпитализации. В случае развития приступа стенокардии следует вновь оценить степень поражения коронарных артерий и, при необходимости, адаптировать лечение (лекарственную терапию или возможное проведение процедуры реваскуляризации). \u003Cbr\u003EТриметазидин может вызывать или ухудшать симптомы паркинсонизма (тремор, акинезию, повышение тонуса), поэтому следует проводить регулярное наблюдение пациентов, особенно пожилого возраста. В сомнительных случаях пациенты должны быть направлены к неврологу для соответствующего обследования. \u003Cbr\u003EПри появлении двигательных нарушений, таких как симптомы паркинсонизма, синдром «беспокойных ног», тремор, неустойчивость походки, триметазидин следует окончательно отменить. Такие случаи редки и симптомы обычно проходят после прекращения терапии: у большинства пациентов - в течение 4 месяцев после отмены триметазидина. \u003Cbr\u003EЕсли симптомы паркинсонизма сохраняются более 4 месяцев после отмены препарата, следует проконсультироваться у невролога. Могут отмечаться случаи падения, связанные с неустойчивостью походки или артериальной гипотензией, особенно у пациентов, принимающих гипотензивные препараты. Следует с осторожностью назначать триметазидин пациентам, у которых возможно повышение его экспозиции: При нарушении функции почек умеренной степени тяжести. У пожилых пациентов старше 75 лет."},{"name":"Взаимодействие","value":"Не было выявлено взаимодействий с другими лекарственными средствами."},{"name":"Регистрационный номер","value":"ЛСР-008140/10"},{"name":"Дата государственной регистрации","value":"27.01.2021"},{"name":"Владелец регистрационного удостоверения","value":"ОЗОН Фармацевтика"},{"name":"Изготовитель","value":"ОЗОН"},{"name":"Фасовщик","value":"ОЗОН"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Антистен МВ"},{"name":"Срок годности","value":"35 мес."}]}],"transitionId":"tr_11321688328772822589"}}}}
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    Триметазидин МВ таб. модиф. высвоб. п/о плен., 35 мг, 60 шт.

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    Цена 224 ₽
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  • Триметазидин мв таб. пролонг. высвоб. п/о плен., 35 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-51ciq947w9w/toggleWishlist":{"skuId":"228090683","productId":1401075802,"offerId":"dFVVL5gyC_JWeqYvZ3QaRA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ0Lao5pGA7757EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI2vCKnAUQu8bhbBiEqbIIINfcwQc=","sign":"exJmB+63k7XXaq/wpUPIDWZ49gai1c55JJjmWBhgkAU="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-51ciq947w9w/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Триметазидин мв таб. пролонг. высвоб. п/о плен., 35 мг, 30 шт.

    Рейтинг товара: 3.7 из 5
    на основе 3 оценки
    Цена 257 ₽
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  • Предуктал ОД капс. с пролонг. высвоб., 80 мг, 30 шт.
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    Предуктал ОД капс. с пролонг. высвоб., 80 мг, 30 шт.

    Рейтинг товара: 4.7 из 5
    на основе 26 оценок
    Цена 1 131 ₽
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  • Депренорм МВ таб. с пролонг. высвоб., п/о плен., 35 мг, 60 шт.
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    Депренорм МВ таб. с пролонг. высвоб., п/о плен., 35 мг, 60 шт.

    Рейтинг товара: 4.9 из 5
    на основе 11 оценок
    Цена 435 ₽
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  • Триметазидин-АКОС МВ таб. с модифиц. высвоб. п/о плен., 35 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-9b4pnsd8pe/toggleWishlist":{"skuId":"101814576325","productId":1741773236,"offerId":"3lI0U9ZJNlZN2fnDUl9LnA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ0Lao5pGA7757EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcItLPFvgYQxcn8pPsCGKbf0Acg19zBBw==","sign":"RpXWYzL4MtWCt3eojfOWMrqTPrm+UI7TYT0/Jrus1e0="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-9b4pnsd8pe/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Триметазидин-АКОС МВ таб. с модифиц. высвоб. п/о плен., 35 мг, 30 шт.

    Рейтинг товара: 4.7 из 5
    на основе 6 оценок
    Цена 349 ₽
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  • Триметазидин таб. п/о плен., 20 мг, 60 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-amjji0a0vga/toggleWishlist":{"skuId":"101775133729","productId":660020030,"offerId":"8s5ylH1EWhlY1yQm42mHNA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ0Lao5pGA7757EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIvrbcugIQoZiVkvsCGM7C2Qcg19zBBw==","sign":"C4Z9n016IZsOc4aMO/V+5xI0G000+MAtIjLHhJpaTbI="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-amjji0a0vga/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Триметазидин таб. п/о плен., 20 мг, 60 шт.

    Рейтинг товара: 5 из 5
    на основе 42 оценки
    Цена 212 ₽
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  • Тримектал МВ таб. модиф. высвоб. п/о плен., 35 мг, 60 шт.
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    Тримектал МВ таб. модиф. высвоб. п/о плен., 35 мг, 60 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 660 ₽
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  • Предизин таб. таб. пролонг. действ., 35 мг, 60 шт.
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    Предизин таб. таб. пролонг. действ., 35 мг, 60 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 783 ₽
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  • Триметазидин таб. п/о плен., 20 мг, 30 шт.
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    Триметазидин таб. п/о плен., 20 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 12 оценок
    Цена 235 ₽
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  • Симвастатин таб. п/о плен., 10 мг, 30 шт.
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    Симвастатин таб. п/о плен., 10 мг, 30 шт.

    Рейтинг товара: 4.8 из 5
    на основе 11 оценок
    Цена 136 ₽
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  • Триметазидин мв таб. модиф. высвоб. п/о плен., 35 мг, 60 шт.
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    Триметазидин мв таб. модиф. высвоб. п/о плен., 35 мг, 60 шт.

    Рейтинг товара: 4.3 из 5
    на основе 3 оценки
    Цена 652 ₽
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Инструкция

Показания к применению

Длительная терапия ишемической болезни сердца: профилактика приступов стабильной стенокардии в составе моно- или комбинированной терапии.

Противопоказания

Повышенная чувствительность к действующему веществу или любому из вспомогательных веществ, входящих в состав лекарственного препарата.
Болезнь Паркинсона, симптомы паркинсонизма, тремор, синдром «беспокойных ног» и другие, связанные с ними двигательные нарушения.
Тяжелая почечная недостаточность (клиренс креатинина менее 30 мл/мин).
Из-за отсутствия достаточного количества клинических данных пациентам до 18 лет назначение лекарственного препарата не рекомендуется.
Беременность и период грудного вскармливания.

Способ применения и дозы

Таблетки следует принимать целиком, не разжевывая, запивая водой. Внутрь, по 1 таблетке 2 раза в сутки, утром и вечером, во время еды. Оценка пользы от лечения должна быть проведена после трех месяцев приема препарата. Прием триметазидина следует прекратить, если за это время улучшение не наступило. Продолжительность лечения определяется врачом.
Особые группы.Пациенты с нарушением функции почек. У пациентов с умеренным нарушением функции почек (КК 30-60 мл/мин) суточная доза составляет 35 мг (1 таблетка), утром во время завтрака.
Пациенты пожилого возраста. У пациентов пожилого возраста может наблюдаться повышенная экспозиция триметазидина из-за возрастного снижения функции почек, У пациентов с умеренным нарушением функции почек (КК 30-60 мл/мин) рекомендованная суточная доза составляет 35 мг (1 таблетка), утром во время завтрака. Подбор дозы у пациентов старше 75 лет должен происходить с осторожностью.
Полная инструкция
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Антистен МВ таб. пролонг. высвоб. п/о плен.
Антистен МВ таб. пролонг. высвоб. п/о плен., 35 мг, 60 шт., 1
5.0
(2)
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Инструкция

453 ₽

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5.0
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У продавца:2 оценки·1 отзыв
У всех продавцов:18 оценок·5 отзывов
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8 месяцев назад • Ирина Корнева • Куплен на Маркете
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