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Описание

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Бикалутамид таб. п/о плен., 50 мг, 30 шт.

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У продавца: 
нет • На Маркете: 4.5
(2)
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Дозировка: 50 мг

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Коротко о товаре

Артикул Маркета
4453139668
Тип препарата
Действующее вещество
Форма выпуска
таблетки
Страна-производитель
Россия
Инструкция
{"widgets":{"@card/SpecsList":{"/content/page/fancyPage/productSpecsList":{"wrapperProps":{"margins":{"top":4,"bottom":4}},"specsLimit":5,"title":"Коротко о товаре","titleSize":"14","type":"minimal","offset":"s","isHealthCategory":true,"forceShowWidget":true,"withFridge":true}}},"meta":{"/content/page/fancyPage/productSpecsList":{"name":"@card/SpecsList"}},"collections":{"minimalSpecs":{"16059977295696162242":{"specItems":[{"name":"Артикул Маркета","value":"4453139668","withCopyValueButton":true},{"name":"тип препарата","value":"рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"действующее вещество","value":"Бикалутамид","transition":{"type":"list","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["27144131:28709949"]}}},{"name":"форма выпуска","value":"таблетки"},{"name":"страна-производитель","value":"Россия"}]}},"compactSpecs":{"16059977295696162242":{"specItems":[{"name":"Артикул Маркета","value":"4453139668","withCopyValueButton":true},{"name":"Тип препарата","value":"Рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"Действующее вещество","value":"Бикалутамид","transition":{"type":"list","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["27144131:28709949"]}}},{"name":"Форма выпуска","value":"Таблетки"},{"name":"Страна-производитель","value":"Россия"}]}},"fullSpecs":{"16059977295696162242":{"specItems":[{"name":"Тип препарата","value":"лекарственный препарат","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["34324371:35649313"]}}},{"name":"Рецептурный препарат","value":"да","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["27272850:1,0"]}}},{"name":"Органы и системы","value":"половые железы","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["34045610:34516009"]}}},{"name":"Показания к применению","value":"В комбинации с аналогом ГнРГ (гонадотропин-рилизинг-гормон) или хирургической кастрацией для лечения распространенного рака предстательной железы."},{"name":"Противопоказания","value":"- Повышенная чувствительность к бикалутамиду или другим компонентам препарата;\u003Cbr\u003E- одновременный прием с терфенадином, астемизолом и цизапридом;\u003Cbr\u003E- детский возраст, женский пол."},{"name":"Состав","value":"1 таблетка, покрытая пленочной оболочкой, 50,0 мг содержит:\u003Cbr\u003Eактивное вещество: бикалутамид 50,0 мг;\u003Cbr\u003Eвспомогательные вещества (ядро): лактозы моногидрат (сахар молочный) 29,50 мг, целлюлоза микрокристаллическая 10,30 мг, карбоксиметилкрахмал натрия 4,00 мг, повидон-К17 4,00 мг, магния стеарат 0,70 мг, вода 1,50 мг;\u003Cbr\u003Eвспомогательные вещества (оболочка): гипромеллоза 1,65 мг, макрогол-4000 0,45 мг, титана диоксид 0,90 мг.\u003Cbr\u003E1 таблетка, покрытая пленочной оболочкой, 150,0 мг содержит:\u003Cbr\u003Eактивное вещество: бикалутамид 150,0 мг;\u003Cbr\u003Eвспомогательные вещества (ядро): лактозы моногидрат (сахар молочный) 88,50 мг, целлюлоза микрокристаллическая 30,90 мг, карбоксиметилкрахмал натрия 12,00 мг, повидон-К17 12,00 мг, магния стеарат 2,10 мг, вода 4,50 мг;\u003Cbr\u003Eвспомогательные вещества (оболочка): гипромеллоза 4,95 мг, макрогол-4000 1,35 мг, титана диоксид 2,70 мг."},{"name":"Действующее вещество","value":"Бикалутамид","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["27144131:28709949"]}}},{"name":"Способ применения и дозы","value":"Внутрь, вне зависимости от приема пищи, запить достаточным количеством жидкости.\u003Cbr\u003EВзрослым и пожилым мужчинам при распространенном раке предстательной железы в комбинации с аналогом ГнРГ или хирургической кастрацией - по 50 мг 1 раз в сутки. Лечение препаратом необходимо начинать одновременно с началом приема аналога ГнРГ или хирургической кастрацией.\u003Cbr\u003EВзрослым и пожилым мужчинам, при местнораспространенном раке предстательной железы - по 150 мг 1 раз в сутки. Препарат следует принимать длительно, как минимум в течение 2 лет. При появлении признаков прогрессирования заболевания прием препарата следует прекратить.\u003Cbr\u003EНе требуется коррекции дозы у пациентов с нарушенной функцией почек, легкими нарушениями функции печени. У пациентов со средними и тяжелыми нарушениями функции печени может наблюдаться повышенная кумуляция бикалутамида."},{"name":"Побочные действия","value":"Частота побочных реакций, приведенных ниже, определялась соответственно следующим критериям: очень часто (не менее 1/10), часто (более 1/100, менее 1/10); нечасто (более 1/1000, менее 1/100); редко (более 1/10000, менее 1/1000); очень редко (менее 1/10000), включая отдельные сообщения.\u003Cbr\u003EНарушения со стороны иммунной системы:\u003Cbr\u003EРедко - реакции повышенной чувствительности, включая ангионевротический отек, крапивницу, кожная сыпь.\u003Cbr\u003EНарушения со стороны эндокринной системы:\u003Cbr\u003EОчень часто - гинекомастия (может сохраняться даже после прекращения терапии, особенно в случае приема препарата в течение длительного времени), болезненность грудных желез;\u003Cbr\u003EЧасто - снижение полового влечения, эректильная дисфункция, повышение массы тела, гипергликемия.\u003Cbr\u003EНарушения со стороны нервной системы:\u003Cbr\u003EЧасто - астения, головная боль, головокружение, бессонница или сонливость, тревожность, снижение аппетита;\u003Cbr\u003EРедко - депрессия, \"приливы\" крови к лицу.\u003Cbr\u003EНарушения со стороны сердца:\u003Cbr\u003EЧасто - инфаркт миокарда (сообщалось о случаях с фатальным исходом)*, развитие или усугубление сердечной недостаточности*, повышение артериального давления.\u003Cbr\u003EНарушения со стороны дыхательной системы, органов грудной клетки и средостения:\u003Cbr\u003EРедко - одышка, боль в груди, кашель, фарингит, бронхит, пневмония, интерстициальные легочные заболевания (в том числе с фатальным исходом), ринит.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта:\u003Cbr\u003EЧасто - тошнота;\u003Cbr\u003EРедко - боль в животе, диспепсия, запор, диарея, рвота, метеоризм.\u003Cbr\u003EНарушения со стороны печени и желчевыводящих путей:\u003Cbr\u003EРедко - транзиторное повышение активности \"печеночных\" трансаминаз, желтуха;\u003Cbr\u003EОчень редко - печеночная недостаточность (в том числе с фатальным исходом).\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей:\u003Cbr\u003EЧасто - алопеция, гирсутизм или восстановление роста волос, сухость кожи, кожный зуд. Нарушения со стороны скелетно-мышечной и соединительной ткани;\u003Cbr\u003EЧасто - миастения, миалгия, судороги, артрит, контрактуры суставов.\u003Cbr\u003EНарушения со стороны почек и мочевыводящих путей:\u003Cbr\u003EНечасто - дизурия, полиурия, задержка мочи, периферические отеки;\u003Cbr\u003EРедко - гематурия.\u003Cbr\u003EОбщие расстройства и нарушение в месте введения:\u003Cbr\u003EЧасто - лихорадка, гриппоподобный синдром, озноб, повышенное потоотделение, боль в области малого таза, инфекции.\u003Cbr\u003EНарушения со стороны крови и лимфатической системы:\u003Cbr\u003EЧасто: анемия.\u003Cbr\u003E*наблюдались при лечении рака предстательной железы в комбинации с аналогом ГнРГ. Риск развития увеличивался при одновременном применении бикалутамида в дозе 50 мг с аналогом ГнРГ. В случае применения бикалутамида в дозе 150 мг в качестве монотерапии для лечения рака предстательной железы увеличение частоты развития не было очевидным."},{"name":"Фармакологическое действие","value":"Бикалутамид представляет собой рацемическую смесь с нестероидной антиандрогенной активностью преимущественно (R)-энантиомера, не обладает иной эндокринной активностью. Бикалутамид связывается с андрогенными рецепторами и, не активируя экспрессию генов, подавляет стимулирующее влияние на них андрогенов. Результатом этого является регрессия новообразований предстательной железы.\u003Cbr\u003E\nУ некоторых пациентов прекращение приема препарата может привести к развитию клинического синдрома отмены антиандрогенов.\u003Cbr\u003EПри применении бикалутамида в суточной дозе 150 мг ежедневно для лечения пациентов с местнораспространенным (Т3-Т4, любое N, М0 или любое Т, N+, М0) раком предстательной железы в качестве монотерапии или адъювантной терапии значительно снижается риск прогрессирования заболевания и метастазов в кости.\u003Cbr\u003EПри местнораспространенном раке предстательной железы отмечена тенденция к улучшению показателей продолжительности жизни без признаков прогрессирования заболевания в группах пациентов, принимавших бикалутамид в дозе 150 мг в качестве монотерапии или адъювантной терапии по сравнению со стандартной терапией (хирургическое лечение, лучевая терапия).\u003Cbr\u003EПоказано увеличение продолжительности жизни среди пациентов с местнораспространенным раком предстательной железы, получавших бикалутамид в дозе 150 мг в качестве монотерапии и в качестве адъювантного лечения в комбинации с лучевой терапией."},{"name":"Фармакологическая группа","value":"противоопухолевые средства","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["34045110:34518988"]}}},{"name":"Форма выпуска","value":"таблетки"},{"name":"Пол","value":"для мужчин"},{"name":"Условия хранения","value":"В защищенном от света месте, при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Исходя из пострегистрационных данных, передозировка метотрексатом обычно возникала после перорального применения, однако может происходить и при внутривенном или внутримышечном введении. В сообщениях о пероральной передозировке сообщалось о случайном приеме недельной дозы ежедневно (общая доза или разделенная на несколько однократных доз).\u003Cbr\u003E\nСимптомы: главным образом наблюдаются симптомы, связанные с угнетением системы кроветворения и со стороны пищеварительной системы (лейкопения, тромбоцитопения, анемия, панцитопения, нейтропения, миелосупрессия, мукозит, стоматит, язвы в ротовой полости, тошнота, рвота, изъязвления и кровотечения в ЖКТ). В некоторых случаях симптомов токсичности не было.\u003Cbr\u003E\nТакже имеются сообщения о летальном исходе в результате передозировки. В этих случаях дополнительно сообщалось о сепсисе, септическом шоке, почечной недостаточности и апластической анемии.\u003Cbr\u003E\nЛечение: специфическим антидотом метотрексата является кальция фолинат. Он нейтрализует неблагоприятные токсические эффекты.\nПри случайной передозировке не позже чем через 4-5 ч после применения метотрексата вводят кальция фолинат (внутривенно или внутримышечно) в дозе, равной или превышающей дозу метотрексата. Введение кальция фолината продолжают до снижения концентрации метотрексата в сыворотке крови ниже 10 ммоль/л.\u003Cbr\u003E\nПри значительной передозировке может потребоваться гидратация организма и ощелачивание мочи (pH более 7) для предотвращения выпадения осадка метотрексата и/или его метаболитов в почечных канальцах. Гемодиализ и перитонеальный диализ не улучшают элиминации метотрексата. Обеспечить эффективный клиренс метотрексата позволяет интенсивный интермиттирующий гемодиализ с использованием высокопроницаемых (\"high-flux\") диализаторов.\n."},{"name":"Применение при беременности и кормлении грудью","value":"Бикалутамид противопоказан женщинам и не должен назначаться беременным и кормящим матерям."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"При применении бикалутамида может наблюдаться сонливость и головокружение, в связи с чем следует соблюдать осторожность при управлении автотранспортом или иными движущимися механизмами. При появлении указанных побочных эффектов следует воздержаться от выполнения данных видов деятельности."},{"name":"Особые указания","value":"Бикалутамид интенсивно метаболизируется в печени. Учитывая возможность замедления выведения бикалутамида и кумуляции бикалутамида у больных с выраженным нарушением функции печени, целесообразно периодически оценивать функцию печени. Большинство изменений функции печени встречаются в течение первых шести месяцев лечения препаратом.\u003Cbr\u003EБикалутамид следует применять с осторожностью у больных со средним и тяжелым нарушением функции печени.\u003Cbr\u003EТяжелые нарушения печени при использовании препарата возникают редко, сообщалось о случаях с фатальным исходом. В случае развития выраженных изменений функции печени и/или повышении функциональных проб более чем в 2 раза прием препарата необходимо прекратить.\u003Cbr\u003EПри совместном приеме с циклоспорином, после начала использования или отмены бикалутамида рекомендуется проводить тщательный контроль концентрации циклоспорина в плазме и состояния пациента.\u003Cbr\u003EУ пациентов с прогрессированием заболевания на фоне повышения концентрации простатспецифического антигена (ПСА) необходимо рассмотреть вопрос о прекращении лечения бикалутамидом.\u003Cbr\u003EУчитывая возможность ингибирования препаратом активности цитохрома Р450 (изофермента CYP 3А4), следует проявлять осторожность при одновременном применении бикалутамида с препаратами, преимущественно метаболизирующимися с участием изофермента CYP 3А4. Рекомендуется регулярно контролировать протромбиновое время при назначении бикалутамида пациентам, получающим непрямые антикоагулянты кумаринового ряда.\u003Cbr\u003EУ пациентов, принимающих агонисты ГнРГ, наблюдалось снижение переносимости глюкозы. Этот эффект может приводить к развитию сахарного диабета или снижению толерантности к глюкозе у пациентов с сахарным диабетом. В связи с чем у пациентов, принимающих бикалутамид в комбинации с агонистами ГнРГ, необходимо контролировать концентрацию глюкозы в крови."},{"name":"Взаимодействие","value":"Нет данных о фармакокинетических или фармакодинамических взаимодействиях между бикалутамидом и аналогами ГнРГ.\u003Cbr\u003E(R)-энантиомер бикалутамида является ингибитором изофермента CYP3A4, в меньшей степени влияя на активность изоферментов CYP2C9, 2С19 и 2D6. Потенциальной способности бикалутамида к взаимодействию с другими лекарственными препаратами не обнаружено, однако при использовании препарата в течение 28 дней на фоне приема мидазолама, площадь под кривой \"концентрация-время\" (AUC) мидазолама увеличивается на 80%.\u003Cbr\u003EИнгибирование изофермента CYP 3А4 под действием бикалутамида может иметь значение при применении лекарственных препаратов с узким терапевтическим индексом, которые метаболизируются в печени. В связи с этим одновременное применение бикалутамида с терфенадином, астемизолом, цизапридом противопоказано.\u003Cbr\u003EСледует соблюдать осторожность при назначении бикалутамида одновременно с циклоспорином или блокаторами \"медленных\" кальциевых каналов. Возможно, потребуется снижение дозы этих препаратов, особенно в случае потенцирования или развития побочных реакций. После начала использования или отмены бикалутамида рекомендуют проводить тщательный мониторинг концентрации циклоспорина в плазме и клинического состояния пациента.\u003Cbr\u003EОдновременное применение бикалутамида и препаратов, угнетающих микросомальное окисление лекарственных средств, например циметидина или кетоконазола, может привести к увеличению концентрации бикалутамида в плазме и, возможно, частоты возникновения побочных эффектов.\u003Cbr\u003EУсиливает действие антикоагулянтов кумаринового ряда (варфарин)."},{"name":"Источник","value":"\u003Ca href=\"https://www.vidal.ru\" target=\"_blank\"\u003EСправочник лекарственных препаратов Видаль<\u002Fa\u003E"},{"name":"Регистрационный номер","value":"ЛП-002358"},{"name":"Дата государственной регистрации","value":"04.02.2019"},{"name":"Владелец регистрационного удостоверения","value":"Атолл","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["34324371:35649313","7893318:17601668"]}}},{"name":"Изготовитель","value":"ОЗОН"},{"name":"Фасовщик","value":"ОЗОН"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Бикалутамид","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["17796364:18040662"]}}},{"name":"Срок годности","value":"750 дн."}]}},"fullSpecsGrouped":{"16059977295696162242":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"половые железы"},{"name":"Показания к применению","value":"В комбинации с аналогом ГнРГ (гонадотропин-рилизинг-гормон) или хирургической кастрацией для лечения распространенного рака предстательной железы."},{"name":"Противопоказания","value":"- Повышенная чувствительность к бикалутамиду или другим компонентам препарата;\u003Cbr\u003E- одновременный прием с терфенадином, астемизолом и цизапридом;\u003Cbr\u003E- детский возраст, женский пол."},{"name":"Состав","value":"1 таблетка, покрытая пленочной оболочкой, 50,0 мг содержит:\u003Cbr\u003Eактивное вещество: бикалутамид 50,0 мг;\u003Cbr\u003Eвспомогательные вещества (ядро): лактозы моногидрат (сахар молочный) 29,50 мг, целлюлоза микрокристаллическая 10,30 мг, карбоксиметилкрахмал натрия 4,00 мг, повидон-К17 4,00 мг, магния стеарат 0,70 мг, вода 1,50 мг;\u003Cbr\u003Eвспомогательные вещества (оболочка): гипромеллоза 1,65 мг, макрогол-4000 0,45 мг, титана диоксид 0,90 мг.\u003Cbr\u003E1 таблетка, покрытая пленочной оболочкой, 150,0 мг содержит:\u003Cbr\u003Eактивное вещество: бикалутамид 150,0 мг;\u003Cbr\u003Eвспомогательные вещества (ядро): лактозы моногидрат (сахар молочный) 88,50 мг, целлюлоза микрокристаллическая 30,90 мг, карбоксиметилкрахмал натрия 12,00 мг, повидон-К17 12,00 мг, магния стеарат 2,10 мг, вода 4,50 мг;\u003Cbr\u003Eвспомогательные вещества (оболочка): гипромеллоза 4,95 мг, макрогол-4000 1,35 мг, титана диоксид 2,70 мг."},{"name":"Действующее вещество","value":"Бикалутамид"},{"name":"Способ применения и дозы","value":"Внутрь, вне зависимости от приема пищи, запить достаточным количеством жидкости.\u003Cbr\u003EВзрослым и пожилым мужчинам при распространенном раке предстательной железы в комбинации с аналогом ГнРГ или хирургической кастрацией - по 50 мг 1 раз в сутки. Лечение препаратом необходимо начинать одновременно с началом приема аналога ГнРГ или хирургической кастрацией.\u003Cbr\u003EВзрослым и пожилым мужчинам, при местнораспространенном раке предстательной железы - по 150 мг 1 раз в сутки. Препарат следует принимать длительно, как минимум в течение 2 лет. При появлении признаков прогрессирования заболевания прием препарата следует прекратить.\u003Cbr\u003EНе требуется коррекции дозы у пациентов с нарушенной функцией почек, легкими нарушениями функции печени. У пациентов со средними и тяжелыми нарушениями функции печени может наблюдаться повышенная кумуляция бикалутамида."},{"name":"Побочные действия","value":"Частота побочных реакций, приведенных ниже, определялась соответственно следующим критериям: очень часто (не менее 1/10), часто (более 1/100, менее 1/10); нечасто (более 1/1000, менее 1/100); редко (более 1/10000, менее 1/1000); очень редко (менее 1/10000), включая отдельные сообщения.\u003Cbr\u003EНарушения со стороны иммунной системы:\u003Cbr\u003EРедко - реакции повышенной чувствительности, включая ангионевротический отек, крапивницу, кожная сыпь.\u003Cbr\u003EНарушения со стороны эндокринной системы:\u003Cbr\u003EОчень часто - гинекомастия (может сохраняться даже после прекращения терапии, особенно в случае приема препарата в течение длительного времени), болезненность грудных желез;\u003Cbr\u003EЧасто - снижение полового влечения, эректильная дисфункция, повышение массы тела, гипергликемия.\u003Cbr\u003EНарушения со стороны нервной системы:\u003Cbr\u003EЧасто - астения, головная боль, головокружение, бессонница или сонливость, тревожность, снижение аппетита;\u003Cbr\u003EРедко - депрессия, \"приливы\" крови к лицу.\u003Cbr\u003EНарушения со стороны сердца:\u003Cbr\u003EЧасто - инфаркт миокарда (сообщалось о случаях с фатальным исходом)*, развитие или усугубление сердечной недостаточности*, повышение артериального давления.\u003Cbr\u003EНарушения со стороны дыхательной системы, органов грудной клетки и средостения:\u003Cbr\u003EРедко - одышка, боль в груди, кашель, фарингит, бронхит, пневмония, интерстициальные легочные заболевания (в том числе с фатальным исходом), ринит.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта:\u003Cbr\u003EЧасто - тошнота;\u003Cbr\u003EРедко - боль в животе, диспепсия, запор, диарея, рвота, метеоризм.\u003Cbr\u003EНарушения со стороны печени и желчевыводящих путей:\u003Cbr\u003EРедко - транзиторное повышение активности \"печеночных\" трансаминаз, желтуха;\u003Cbr\u003EОчень редко - печеночная недостаточность (в том числе с фатальным исходом).\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей:\u003Cbr\u003EЧасто - алопеция, гирсутизм или восстановление роста волос, сухость кожи, кожный зуд. Нарушения со стороны скелетно-мышечной и соединительной ткани;\u003Cbr\u003EЧасто - миастения, миалгия, судороги, артрит, контрактуры суставов.\u003Cbr\u003EНарушения со стороны почек и мочевыводящих путей:\u003Cbr\u003EНечасто - дизурия, полиурия, задержка мочи, периферические отеки;\u003Cbr\u003EРедко - гематурия.\u003Cbr\u003EОбщие расстройства и нарушение в месте введения:\u003Cbr\u003EЧасто - лихорадка, гриппоподобный синдром, озноб, повышенное потоотделение, боль в области малого таза, инфекции.\u003Cbr\u003EНарушения со стороны крови и лимфатической системы:\u003Cbr\u003EЧасто: анемия.\u003Cbr\u003E*наблюдались при лечении рака предстательной железы в комбинации с аналогом ГнРГ. Риск развития увеличивался при одновременном применении бикалутамида в дозе 50 мг с аналогом ГнРГ. В случае применения бикалутамида в дозе 150 мг в качестве монотерапии для лечения рака предстательной железы увеличение частоты развития не было очевидным."},{"name":"Фармакологическое действие","value":"Бикалутамид представляет собой рацемическую смесь с нестероидной антиандрогенной активностью преимущественно (R)-энантиомера, не обладает иной эндокринной активностью. Бикалутамид связывается с андрогенными рецепторами и, не активируя экспрессию генов, подавляет стимулирующее влияние на них андрогенов. Результатом этого является регрессия новообразований предстательной железы.\u003Cbr\u003E\nУ некоторых пациентов прекращение приема препарата может привести к развитию клинического синдрома отмены антиандрогенов.\u003Cbr\u003EПри применении бикалутамида в суточной дозе 150 мг ежедневно для лечения пациентов с местнораспространенным (Т3-Т4, любое N, М0 или любое Т, N+, М0) раком предстательной железы в качестве монотерапии или адъювантной терапии значительно снижается риск прогрессирования заболевания и метастазов в кости.\u003Cbr\u003EПри местнораспространенном раке предстательной железы отмечена тенденция к улучшению показателей продолжительности жизни без признаков прогрессирования заболевания в группах пациентов, принимавших бикалутамид в дозе 150 мг в качестве монотерапии или адъювантной терапии по сравнению со стандартной терапией (хирургическое лечение, лучевая терапия).\u003Cbr\u003EПоказано увеличение продолжительности жизни среди пациентов с местнораспространенным раком предстательной железы, получавших бикалутамид в дозе 150 мг в качестве монотерапии и в качестве адъювантного лечения в комбинации с лучевой терапией."},{"name":"Фармакологическая группа","value":"противоопухолевые средства"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Пол","value":"для мужчин"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"В защищенном от света месте, при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Исходя из пострегистрационных данных, передозировка метотрексатом обычно возникала после перорального применения, однако может происходить и при внутривенном или внутримышечном введении. В сообщениях о пероральной передозировке сообщалось о случайном приеме недельной дозы ежедневно (общая доза или разделенная на несколько однократных доз).\u003Cbr\u003E\nСимптомы: главным образом наблюдаются симптомы, связанные с угнетением системы кроветворения и со стороны пищеварительной системы (лейкопения, тромбоцитопения, анемия, панцитопения, нейтропения, миелосупрессия, мукозит, стоматит, язвы в ротовой полости, тошнота, рвота, изъязвления и кровотечения в ЖКТ). В некоторых случаях симптомов токсичности не было.\u003Cbr\u003E\nТакже имеются сообщения о летальном исходе в результате передозировки. В этих случаях дополнительно сообщалось о сепсисе, септическом шоке, почечной недостаточности и апластической анемии.\u003Cbr\u003E\nЛечение: специфическим антидотом метотрексата является кальция фолинат. Он нейтрализует неблагоприятные токсические эффекты.\nПри случайной передозировке не позже чем через 4-5 ч после применения метотрексата вводят кальция фолинат (внутривенно или внутримышечно) в дозе, равной или превышающей дозу метотрексата. Введение кальция фолината продолжают до снижения концентрации метотрексата в сыворотке крови ниже 10 ммоль/л.\u003Cbr\u003E\nПри значительной передозировке может потребоваться гидратация организма и ощелачивание мочи (pH более 7) для предотвращения выпадения осадка метотрексата и/или его метаболитов в почечных канальцах. Гемодиализ и перитонеальный диализ не улучшают элиминации метотрексата. Обеспечить эффективный клиренс метотрексата позволяет интенсивный интермиттирующий гемодиализ с использованием высокопроницаемых (\"high-flux\") диализаторов.\n."},{"name":"Применение при беременности и кормлении грудью","value":"Бикалутамид противопоказан женщинам и не должен назначаться беременным и кормящим матерям."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"При применении бикалутамида может наблюдаться сонливость и головокружение, в связи с чем следует соблюдать осторожность при управлении автотранспортом или иными движущимися механизмами. При появлении указанных побочных эффектов следует воздержаться от выполнения данных видов деятельности."},{"name":"Особые указания","value":"Бикалутамид интенсивно метаболизируется в печени. Учитывая возможность замедления выведения бикалутамида и кумуляции бикалутамида у больных с выраженным нарушением функции печени, целесообразно периодически оценивать функцию печени. Большинство изменений функции печени встречаются в течение первых шести месяцев лечения препаратом.\u003Cbr\u003EБикалутамид следует применять с осторожностью у больных со средним и тяжелым нарушением функции печени.\u003Cbr\u003EТяжелые нарушения печени при использовании препарата возникают редко, сообщалось о случаях с фатальным исходом. В случае развития выраженных изменений функции печени и/или повышении функциональных проб более чем в 2 раза прием препарата необходимо прекратить.\u003Cbr\u003EПри совместном приеме с циклоспорином, после начала использования или отмены бикалутамида рекомендуется проводить тщательный контроль концентрации циклоспорина в плазме и состояния пациента.\u003Cbr\u003EУ пациентов с прогрессированием заболевания на фоне повышения концентрации простатспецифического антигена (ПСА) необходимо рассмотреть вопрос о прекращении лечения бикалутамидом.\u003Cbr\u003EУчитывая возможность ингибирования препаратом активности цитохрома Р450 (изофермента CYP 3А4), следует проявлять осторожность при одновременном применении бикалутамида с препаратами, преимущественно метаболизирующимися с участием изофермента CYP 3А4. Рекомендуется регулярно контролировать протромбиновое время при назначении бикалутамида пациентам, получающим непрямые антикоагулянты кумаринового ряда.\u003Cbr\u003EУ пациентов, принимающих агонисты ГнРГ, наблюдалось снижение переносимости глюкозы. Этот эффект может приводить к развитию сахарного диабета или снижению толерантности к глюкозе у пациентов с сахарным диабетом. В связи с чем у пациентов, принимающих бикалутамид в комбинации с агонистами ГнРГ, необходимо контролировать концентрацию глюкозы в крови."},{"name":"Взаимодействие","value":"Нет данных о фармакокинетических или фармакодинамических взаимодействиях между бикалутамидом и аналогами ГнРГ.\u003Cbr\u003E(R)-энантиомер бикалутамида является ингибитором изофермента CYP3A4, в меньшей степени влияя на активность изоферментов CYP2C9, 2С19 и 2D6. Потенциальной способности бикалутамида к взаимодействию с другими лекарственными препаратами не обнаружено, однако при использовании препарата в течение 28 дней на фоне приема мидазолама, площадь под кривой \"концентрация-время\" (AUC) мидазолама увеличивается на 80%.\u003Cbr\u003EИнгибирование изофермента CYP 3А4 под действием бикалутамида может иметь значение при применении лекарственных препаратов с узким терапевтическим индексом, которые метаболизируются в печени. В связи с этим одновременное применение бикалутамида с терфенадином, астемизолом, цизапридом противопоказано.\u003Cbr\u003EСледует соблюдать осторожность при назначении бикалутамида одновременно с циклоспорином или блокаторами \"медленных\" кальциевых каналов. Возможно, потребуется снижение дозы этих препаратов, особенно в случае потенцирования или развития побочных реакций. После начала использования или отмены бикалутамида рекомендуют проводить тщательный мониторинг концентрации циклоспорина в плазме и клинического состояния пациента.\u003Cbr\u003EОдновременное применение бикалутамида и препаратов, угнетающих микросомальное окисление лекарственных средств, например циметидина или кетоконазола, может привести к увеличению концентрации бикалутамида в плазме и, возможно, частоты возникновения побочных эффектов.\u003Cbr\u003EУсиливает действие антикоагулянтов кумаринового ряда (варфарин)."},{"name":"Источник","value":"\u003Ca href=\"https://www.vidal.ru\" target=\"_blank\"\u003EСправочник лекарственных препаратов Видаль<\u002Fa\u003E"},{"name":"Регистрационный номер","value":"ЛП-002358"},{"name":"Дата государственной регистрации","value":"04.02.2019"},{"name":"Владелец регистрационного удостоверения","value":"Атолл"},{"name":"Изготовитель","value":"ОЗОН"},{"name":"Фасовщик","value":"ОЗОН"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Бикалутамид"},{"name":"Срок годности","value":"750 дн."}]}],"transitionId":"tr_9103967885017958823"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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1 119 ₽

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    Бикалутамид Канон таб. п/о плен., 50 мг, 30 шт.

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  • Бикалутамид-тева таб. п/о плен., 50 мг, 28 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-oijj7ouj19p/toggleWishlist":{"skuId":"101333033749","productId":227830073,"offerId":"sBgYg3Av3MSDvcGHwdRCeQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhaiQoci3iMgoEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIudLRbBCVxq2/+QIY1v2NByDy3MEH","sign":"ocF/nn/o/fP7GyoE8UrdDJWo+ByjDqsb6tBqy6COLpI="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-oijj7ouj19p/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Бикалутамид-тева таб. п/о плен., 50 мг, 28 шт.

    Рейтинг товара: 4.5 из 5
    на основе 24 оценки
    Цена 823 ₽
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-oijj7ouj19p/addToCartButton":{"offerId":"sBgYg3Av3MSDvcGHwdRCeQ","skuId":"101333033749","pendingCartItem":{"productId":227830073,"offerId":"sBgYg3Av3MSDvcGHwdRCeQ","showPlaceId":"OTNDnItfwRMjN9MRHuEMMiUkxGpqC0m5RgkQupZLPSoEZ5-N6r17YjSrNfDzh5p6ZAKUePib3WFVKOaMEEwf4nssa6n17ql3WNzmJ0Piig8fpHWcim95xBRgau6XRqNayIYMgGmxgfrkthJQ3PIlvmhH2vWCXaZZIY2r3yS7UZz84-MVoAGKOxGJBlkLaVQCZiFDrMjWVOJMQy2qUaDxiQ,,","feeShow":"OTNDnItfwRMjN9MRHuEMMiUkxGpqC0m5RgkQupZLPSoEZ5-N6r17YjSrNfDzh5p6ZAKUePib3WFVKOaMEEwf4nssa6n17ql3WNzmJ0Piig8fpHWcim95xBRgau6XRqNayIYMgGmxgfrkthJQ3PIlvmhH2vWCXaZZIY2r3yS7UZz84-MVoAGKOxGJBlkLaVQCZiFDrMjWVOJMQy2qUaDxiQ,,","skuId":"101333033749","shopId":55106433,"price":{"applicablePriceDiscounts":[],"value":"823","currency":"RUR"},"hid":"15756914","name":"Бикалутамид-тева таб. п/о плен., 50 мг, 28 шт.","label":"s1y075jii59","count":0,"features":[],"imageMeta":{"namespace":"mpic","groupId":7388241,"key":"img_id3783403691274406228.jpeg"}},"quantity":{"step":1,"minimum":1,"maximum":999},"cpaUrl":"/safeclick/data=TxNGOK9vJEN7oLFLeCTKEixJYuEMI0EzvZFs82AjjgjhTwweZ7mRXd_AQ0K184sfZmy5nQz7U8xIc-qdVOMFoxnoSww2ObzLEs1KJpltGipDSanCui6QCo8GXRHxAQaqQQZbzp5kb0bdQDXqQiIIDEwL4INEBUjrbUNtjxqZ96UWkyu_L0koKdYI_V7KKdklxXX5C6HTDbiEfidm937rYVuGR6bDDywBHPXZbp73gCtAPEemmZ3pGvY6pEBFSec0HvqF3-ooeBpEL7_9mLiMD6en0Wn5nKsdweBQk-mFPBGkB2NJJ53mlJBcpuIP3UOJNHCMmOouM1ztTs2NGwIbGAEf9B8hxYpF3H1-GynsJMMlSdE7JDw-sfJrAxs_FYoqIep351T9Uf8sv2PUioTawng5D0dMeuIBKN1t2fz-_y8wfwuxorySCLev01TSIIWohw3ybk3YEK9Ehcym3fhzIs2tmoGfbYozGBXJAcR3dioUIK08W9Sn1DapRfRGPXT_Qgq4zvDMywm7-butCU1bZc49i6T_CCG5AvlvwviszvoKtHyCzuHqkb0x2ove8wCvaaRTB9isIoT70IfHP_c-rRZXhKRLYiqkBfgTW1nrhzNs3dFupYEXCScy89z7SVso5ft6JizcUne7XaHt8MK5F-TWyMDuIQsr-rd0dctXqBGnPWyqBUTXtH-SDpWt20VTKZeTLigSaKhSSRBUfG_33FuqnUZg4z7AyKDisCHpEuooXZ7AMejWQ641ZR7g6m9raTREL-IoFsDvwCWgmuvcsEpg0LIsilpUPentsIWbbWvcKf93ZRZwa6kVnIQQXVFcDkzEm3pkAR2V9sgmbI-BQKL48u0U8eVBY2Sy1zF0SU5vVD6ybkh6eZe9fazqbHAlQh0ycoUPeiDBUTBADc41UntbcpeU7wagubARnrVRA1P2UmPGP3Ze4Kq124J94sZs0nS67IV_ZFIVOVHpNT1A9NKbmBq6epKhSz_g-j6gAN4-DcC6pq4paq79C8WjevzVcOGghGQvQKIu0aYcVM5XuJaE1Wm8oJEgI2oDBz66XJziZL96_hJb97nLZ9vm-LmLRioH75ZBHLTRObIvTkaNuoSGq_fkaYVGnBoITQw4Bqx4PwFvlc3CkjHqAGxTUxjdzTfbWd623JHPJRwU2O8IuVEGR4699zjQ3b88GGO8vtnArluHjwzxYLvNXAAvAkM56Fb8PJFBg6VLpauFhcTGU-BrvvOKiUeQ9b78cxzXQBn9mcYE_FS8WewtgQK1Pg8Kl8sc5flzB3VqBt0dSfppCa8vR_TIfkZgO8x97DAoo0yP5GVnvxGS-4uKt2RkKIV3jQ8JfElEL5iMkWMawJPCvkK8lXcssJ9XbLFIBmNpd57Nxyef5Fn-K7hVO4AJGiJHSNqz0x-8OMEWM4cjT0WCBB6gYGnsMe2I-ViIKZl9HK9snYw7JDq3uMJeB4hGBYqqg3ggAkA8Q8UeJfOc_P7MNLhiBx7N1vBLhQfjqSgUU_dYqqtjf14v3Vm89Z3xCBDsOwS73m7m3uW6nZQiGJko7w3RT5c7_GybxQeTsqhAt-G-hIgGBUzUXEHU0Wa37CSPYjXkfQXmrZX1MNHsIgiawolJESUf6fqr6zv8yYbu7dMUzr8moKtEj_HoAA0Mjx7uI34J_XMhLPbpuHSVVWx4hcuWUk9LbRPOCVaZWw-opU_ByrvuFhR015RW4YYfUSGmFKr8NxNtwuKWJICd_u7yg6kctrqPYlHIYgpzEzsl3Qozy-uA_dVa7kjOgjUJoWWR_8F71AKBovmZdRy7PrlMqnsmIar01mKqr29RCgYWYuUbpGeD8SribcxACI-bEBCO4TQwKmjzNQKRa7XjChzxr6VbOw2K6ZwZ2RjAyC3ep2fJ1hzUOhu7VrHilRM9QBWNGA-4l8BpS9jOmElirREYzME2zxu0y05mxpbVSCf6uTuSkS9OtPE85qITY16GCoqiBgUT60RMXjoVw6f--t3mQ8UrqSH84lzeEDwTnyMZNXSINtGv-nzSbP4byJY6Vm-pCcFPrHg1qfKkYTubDztXi90mBvb_f5mzKHFb8XyAqck7wOAYz2YMUhFzsbVhkwbV8sYtJvU-xGfo25SpGN--p_YxJbfyQAeLQjwisnSNidbcc4qGq5bV6CW8ycQWVONa4RVHvZ2OqiuefCPmd9Mhh7XC_u0uO3HPcjtRrOX47QqwkRQ5RHb5vRqlSztrC5mhMsl5Bzn5qyisyzOieKoo_jNdSwWuUKN62NIJzPsAiO5ntaX6SxZOSLR2XvpVwi96J1g8sEi46IfomideM7VHXFnYCRQcvyJKT1Cuu5ERxuRoYFkEq4k6XCLnMfT7jutZjt6MKseo_z63wL6yU4BUIFNbXwykHsjA3H8dVChVtalxxpf-fvDFVav9wmWyyMgB69X5CMf3THIyhcddSn8gKv9YBfB0td0ARSGz1LQNZKpzcUAFIB5_CL9vyrvA4Fj1ZY-civRLFSzoMMa7ghZfgklw9vpNqmCtM4PR2z4LNkT_Tx2CaIiALIwnbRQ3ph0MJnG1l7CW_pMk-eXX3zQSyfa8u5OUAQXo9hCNLSQid5pSwRlQN7IdH6Fw0CQ_oQEqw42PY-NUTh710zNxkZhqcT9zXOmehgCP0-f86XgoNsAzDWtI0U8xUHx22B1w4ldDrGr5qzU_2-kf7vVkkPLzvQhuT9bhHcguu7fn4SdxUb8JrRB_uB4lrBe_pMLxr_78mxFNtnrdfE9uLMFpUP5Vc52VZeHOtvTxW2nIu7of9sjucenSq88FrSd92xNxGRTAAMzDuuWHBC9XAM4KNeSfYMLfb_cuvy92_9kRsyVoIPK2IGEzOOZXCbvFWQ7ugykpFIFFVx-B4ebLaJgbe8aspY9Wssw57cnOnQHicCzzZigbpoYb5HQENtKmvRMlg4hl5B3bX5EiiM7pAYBTWFgKn3Og0pXKJEApjKJDDAXvQfpUfmQrwi9Q_1iIsEp9OiRiyFM2lGg-TKnJgxqtFIIzb1-IbK-5FaxqqEXt2GmjS5l7_aiN8JDur_AdpLgYWmEQvwUJML-SaEep1tNvC4z9G5yI0G48mz7FOtRu60SevKRFBc4Q4UVmfhLQwwXl1byj7y_-U-QD-UTs04OdikKMf4jD-ocOx6xkpFXBX3WApEf7PAZWRHqoqPMtA3Whkvnbix2-Z3lNvHyV7F-wDQoOpqNrZaOCHQCFIXas61K3bfXldDuHy11lb9M431ruaPWIUPU1C-jK1eP-5mWXS3XgYaUfgzTxXSc7GxQqSiD9k3O0-fDW1ys3nDc7JxhMc5PzLJcSQIfK_-r94M4-vug_QJC64GjATG_muB0eauUvT0PFRy0z9sZIQGTrpEHZnEDzPKMed3EqGn0Qoh8ckO9b28UNnxnEvAq_7wIiymwm7WL1ZS_kZk1YXUv0fjROTXza034MB4GC0mebhWbny2xkf81cGyyg36I_LQh_nUetHgKsJOUI1TvqCcK-FrfpvUlBwcg1AeNdS-owqVn8QzSqQtNpSZDvy4Eg3eAlf6WZkYg,/b64e=1/sign=53acf8ea6256bda20b2cd74e8d5a04bf/keyno=MARKET_1/*","showUid":"17179771621774491053906002","cartLink":"/my/cart","showNotificationWhenDeleteItem":true,"isLavka":false,"isError":false,"isEats":false,"isCR":false,"isM2bEdoOnlyEnable":false,"isEatsMarketIntegration":true,"isCartButtonNext":false,"isUpsalePopupCRExp":false,"baobabClientDataAdditionToCart":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhaiQoci3iMgoEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIudLRbBCVxq2/+QIY1v2NByDy3MEH","sign":"ocF/nn/o/fP7GyoE8UrdDJWo+ByjDqsb6tBqy6COLpI="},"target":"cart_addition"},"baobabClientDataDeletionFromCart":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhaiQoci3iMgoEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIudLRbBCVxq2/+QIY1v2NByDy3MEH","sign":"ocF/nn/o/fP7GyoE8UrdDJWo+ByjDqsb6tBqy6COLpI="},"target":"cart_deletion"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-oijj7ouj19p/addToCartButton":{"name":"@light/AddToCartButtonSnippet"}}}
  • Тамоксифен таб., 10 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-tns5bg61kh9/toggleWishlist":{"skuId":"101335813747","productId":228088817,"offerId":"LwQorKzZd-BaNmUGBkO_eQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhaiQoci3iMgoEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYI8bfhbBDznNfA+QIY1/HPBiDy3MEH","sign":"bQCQIuv8FRBhgXCxc0/cgbRMI1doHGQN0IXsm1+NVl8="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-tns5bg61kh9/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Тамоксифен таб., 10 мг, 30 шт.

    Рейтинг товара: 4.9 из 5
    на основе 38 оценок
    Цена 122 ₽
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  • Микофенолата мофетил таб. п/о плен., 500 мг, 50 шт.
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    Микофенолата мофетил таб. п/о плен., 500 мг, 50 шт.

    Рейтинг товара: 4.2 из 5
    на основе 5 оценок
    Цена 2 276 ₽
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  • Анастрозол таб. п/о плен., 1 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-kx10zyg2lcs/toggleWishlist":{"skuId":"101335816759","productId":453489059,"offerId":"7ctzXJjoyzh8sLMcSGVsug","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhaiQoci3iMgoEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIo+Oe2AEQt7TXwPkCGNfxzwYg8tzBBw==","sign":"Y9+czwv0uKpwYm1VgqpFPcqiU/atQ0XjWP60FCOMvD8="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-kx10zyg2lcs/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Анастрозол таб. п/о плен., 1 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 7 оценок
    Цена 1 295 ₽
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-kx10zyg2lcs/addToCartButton":{"offerId":"7ctzXJjoyzh8sLMcSGVsug","skuId":"101335816759","pendingCartItem":{"productId":453489059,"offerId":"7ctzXJjoyzh8sLMcSGVsug","showPlaceId":"OTNDnItfwRMjN9MRHuEMMiUkxGpqC0m5o5cfuJy_EfixCJT5Y_IlzkPRDkMuvKP3yuedYuHd4_ldSDyk7bTEQorbKEXNNSR1bepsEhwGePc8KkTD046ZLll5IWx54zBBi1E0U3gvoc_zPzxLtdm_AG60hwIYrJZO5OnlfkFSyz1uJCDueuk3n3MtaisEkhkRgL78FyOKwLB6SosdOI6duA,,","feeShow":"OTNDnItfwRMjN9MRHuEMMiUkxGpqC0m5o5cfuJy_EfixCJT5Y_IlzkPRDkMuvKP3yuedYuHd4_ldSDyk7bTEQorbKEXNNSR1bepsEhwGePc8KkTD046ZLll5IWx54zBBi1E0U3gvoc_zPzxLtdm_AG60hwIYrJZO5OnlfkFSyz1uJCDueuk3n3MtaisEkhkRgL78FyOKwLB6SosdOI6duA,,","skuId":"101335816759","shopId":55106433,"price":{"applicablePriceDiscounts":[],"value":"1295","currency":"RUR"},"hid":"15756914","name":"Анастрозол таб. п/о плен., 1 мг, 30 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  • Метотрексат таб. п/о, 2.5 мг, 50 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-617ptss02zc/toggleWishlist":{"skuId":"101335819761","productId":228057918,"offerId":"blNla69qfXW07H4QsxvwFA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhaiQoci3iMgoEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIvsbfbBDxy9fA+QIY1/HPBiDy3MEH","sign":"oCcJCf8cemOXgD5qH4R/xLdGAU7B7k51YZiR31I8f/U="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-617ptss02zc/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Метотрексат таб. п/о, 2.5 мг, 50 шт.

    Рейтинг товара: 5 из 5
    на основе 4 оценки
    Цена 222 ₽
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  • Азатиоприн капс., 50 мг, 50 шт.
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    Азатиоприн капс., 50 мг, 50 шт.

    Рейтинг товара: 4.5 из 5
    на основе 95 оценок
    Цена 790 ₽
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  • Бикана таб. п/о плен., 50 мг, 28 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-rjygpsow3tr/toggleWishlist":{"skuId":"101335821736","productId":228004071,"offerId":"b4qyVKYFmSqeROmDiT8Zsg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhaiQoci3iMgoEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYI56HcbBCo29fA+QIYm4uhBiDy3MEH","sign":"sAwFIbjOl2HNZEhK+sg4laAwHIR0dfVs4Imu8bMPP+k="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-rjygpsow3tr/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Бикана таб. п/о плен., 50 мг, 28 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 881 ₽
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  • Тивикай таб. п/о плен., 50 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-0f9o15ah2hkm/toggleWishlist":{"skuId":"101335161731","productId":677218000,"offerId":"vbC_Wy6_YiXHDqM9DHqOJg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhaiQoci3iMgoEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI0I32wgIQg7evwPkCGLjC2Qcg8tzBBw==","sign":"Z/EJITDwoga+MAhNvRqVtl3/VreqYQFO+kDkrmltgKI="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-0f9o15ah2hkm/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Тивикай таб. п/о плен., 50 мг, 30 шт.

    Рейтинг товара: 4.2 из 5
    на основе 5 оценок
    Цена 7 034 ₽
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  • Лефлуномид таб. п/о плен., 20 мг, 30 шт.
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    Лефлуномид таб. п/о плен., 20 мг, 30 шт.

    Рейтинг товара: 4.8 из 5
    на основе 9 оценок
    Цена 867 ₽
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  • Иммуномакс лиоф. д/приг. р-ра для в/м введ. фл., 200 ЕД, 3 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-r91hswaixu/toggleWishlist":{"skuId":"101570738329","productId":1657040510,"offerId":"PsATGSblWTqF4qx-bolWqw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhaiQoci3iMgoEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI/tyRlgYQmfHZsPoCGNSp2Acg8tzBBw==","sign":"AQeX09H7ksFGi67UVR2MnuO0YlVCR27yK0Eiz3sWQcA="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-r91hswaixu/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Иммуномакс лиоф. д/приг. р-ра для в/м введ. фл., 200 ЕД, 3 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 2 169 ₽
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  • Курадерм крем, 10 мл
    –16 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-2aic05sygc9/toggleWishlist":{"skuId":"101797107145","productId":662065001,"offerId":"u1XiMYoQd1rAdWrGix6XEg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhaiQoci3iMgoEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI6Z7ZuwIQyavSnPsCGJKCjREg8tzBBw==","sign":"K1ZtI4UMiQd8XVjPL/Zhsc0TehagPQfNr+kQK3EQ0zM="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-2aic05sygc9/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Курадерм крем, 10 мл

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 8 571 ₽ вместо 8 745
    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Инструкция

Показания к применению

В комбинации с аналогом ГнРГ (гонадотропин-рилизинг-гормон) или хирургической кастрацией для лечения распространенного рака предстательной железы.

Противопоказания

- Повышенная чувствительность к бикалутамиду или другим компонентам препарата;
- одновременный прием с терфенадином, астемизолом и цизапридом;
- детский возраст, женский пол.

Способ применения и дозы

Внутрь, вне зависимости от приема пищи, запить достаточным количеством жидкости.
Взрослым и пожилым мужчинам при распространенном раке предстательной железы в комбинации с аналогом ГнРГ или хирургической кастрацией - по 50 мг 1 раз в сутки. Лечение препаратом необходимо начинать одновременно с началом приема аналога ГнРГ или хирургической кастрацией.
Взрослым и пожилым мужчинам, при местнораспространенном раке предстательной железы - по 150 мг 1 раз в сутки. Препарат следует принимать длительно, как минимум в течение 2 лет. При появлении признаков прогрессирования заболевания прием препарата следует прекратить.
Не требуется коррекции дозы у пациентов с нарушенной функцией почек, легкими нарушениями функции печени. У пациентов со средними и тяжелыми нарушениями функции печени может наблюдаться повышенная кумуляция бикалутамида.
Полная инструкция
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Бикалутамид таб. п/о плен.
Бикалутамид таб. п/о плен., 50 мг, 30 шт.
У продавца: 
нет • На Маркете: 4.5
(2)
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1 вопрос
Инструкция

1 119 ₽

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