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Описание

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Кетонал таб. п/о плен., 100 мг, 20 шт.

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болезнь Бехтерева, псориатический артрит, реактивный артрит (синдром Рейтера);\u003Cbr\u003Eподагра, псевдоподагра;\u003Cbr\u003Eостеоартроз;\u003Cbr\u003Eтендинит, бурсит, миалгия, невралгия, радикулит;\u003Cbr\u003E- болевой синдром, в том числе слабый, умеренный и выраженный:\u003Cbr\u003Eголовная боль;\u003Cbr\u003Eзубная боль;\u003Cbr\u003Eпосттравматический и послеоперационный болевой синдром;\u003Cbr\u003Eболевой синдром при онкологических заболеваниях;\u003Cbr\u003Eальгодисменорея."},{"name":"Противопоказания","value":"- Гиперчувствительность к кетопрофену или другим компонентам препарата, а также салицилатам или другим НПВП;\u003Cbr\u003E- полное или неполное сочетание бронхиальной астмы, рецидивирующего полипоза носа и околоносовых пазух и непереносимости АСК или других НПВП (в т.ч. в анамнезе);\u003Cbr\u003E- ринит или крапивница в анамнезе, вызванные приемом ацетилсалициловой кислоты или других НПВП;\u003Cbr\u003E- язвенная болезнь желудка или двенадцатиперстной кишки в стадии обострения, язвенный колит, болезнь Крона;\u003Cbr\u003E- гемофилия и другие нарушения свертываемости крови;\u003Cbr\u003E- детский возраст (до 15 лет);\u003Cbr\u003E- тяжелая печеночная недостаточность;\u003Cbr\u003E- тяжелая почечная недостаточность (клиренс креатинина (КК) менее 30 мл/мин);\u003Cbr\u003E- декомпенсированная сердечная недостаточность;\u003Cbr\u003E- послеоперационный период после аортокоронарного шунтирования;\u003Cbr\u003E- желудочно-кишечные, цереброваскулярные и другие кровотечения (или подозрение на кровотечение);\u003Cbr\u003E- прогрессирующие заболевания почек, дивертикулит, активное заболевание печени, воспалительные заболевания кишечника, подтвержденная гиперкалиемия;\u003Cbr\u003E- непереносимость лактозы, дефицит лактазы, синдром глюкозо-галактозной мальабсорбции;\u003Cbr\u003E- хроническая диспепсия;\u003Cbr\u003E- III триместр беременности;\u003Cbr\u003E- период грудного вскармливания."},{"name":"Состав","value":"1 таблетка, покрытая пленочной оболочкой, содержит:\u003Cbr\u003Eядро\tтаблетки:\tДействующее\u003Cbr\u003Eвещество: кетопрофен - 100,000 мг; вспомогательные вещества: магния стеарат - 1,600 мг; кремния диоксид коллоидный безводный 1,200 мг; повидон К 25 - 5,000 мг; крахмал кукурузный - 44,200 мг; тальк - 8,000 мг; лактозы моногидрат - 60,000 мг.\u003Cbr\u003Eсостав\tпленочной\tоболочки: гипромеллоза (4,622 мг), макрогол 400 (0,940 мг), краситель\u003Cbr\u003Eиндигокармин Е 132 (0, 153 мг), титана диоксид (1,054 мг), тальк (0,281 мг), воск карнаубский (0,050 мг).\u003Cbr\u003E"},{"name":"Действующее вещество","value":"Кетопрофен","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-travm-boli-v-myshtsakh-i-sustavakh","categoryId":"15756903","navnodeId":"25542230","glfilters":["27144131:28709512"]}}},{"name":"Способ применения и дозы","value":"Внутрь.\u003Cbr\u003EКетонал таблетки, покрытые пленочной оболочкой, 100 мг следует проглатывать целиком во время или после еды, запивая водой или молоком (объем жидкости должен быть не менее 100 мл).\u003Cbr\u003EОбычно препарат назначают по 1 таблетке 2 раза в день.\u003Cbr\u003EПрепараты для приема внутрь Кетонал можно сочетать с применением ректальных суппозиториев, например, пациент может принять 1 таблетку (100 мг) Кетонал утром и ввести 1 суппозиторий (100 мг) ректально вечером. Максимальная доза кетопрофена составляет 200 мг/сутки.\u003Cbr\u003EНе рекомендуется превышать максимальную суточную дозу препарата.\u003Cbr\u003EС целью снижения риска развития нежелательных явлений со стороны желудочно-кишечного тракта (ЖКТ), пациентам с факторами риска рекомендуется одновременно назначать прием ингибиторов протонной помпы."},{"name":"Побочные действия","value":"По данным Всемирной организации здравоохранения (ВОЗ) нежелательные эффекты классифицированы в соответствии с их частотой развития следующим образом: очень часто (≥1/10), часто (≥1/100, \u003C1/10), нечасто (≥1/1000, \u003C1/100), редко (≥1/10000, \u003C1/1000) и очень редко (\u003C1/10000); частота неизвестна (частоту возникновения явлений нельзя определить на основании имеющихся данных).\u003Cbr\u003EНарушения со стороны системы кроветворения и лимфатической системы\u003Cbr\u003Eредко: геморрагическая анемия; частота неизвестна: агранулоцитоз, тромбоцитопения, нарушение функции костного мозга.\u003Cbr\u003EНарушения со стороны иммунной системы\u003Cbr\u003Eчастота неизвестна: анафилактические реакции (включая анафилактический шок).\u003Cbr\u003EНарушения со стороны нервной системы\u003Cbr\u003Eнечасто: головная боль, головокружение, сонливость; редко: парестезии; частота неизвестна: судороги, нарушение вкусовых ощущений.\u003Cbr\u003EНарушения психики\u003Cbr\u003Eчастота неизвестна: эмоциональная лабильность.\u003Cbr\u003EНарушения со стороны органов чувств\u003Cbr\u003Eредко: нечеткость зрения, шум в ушах.\u003Cbr\u003EНарушения со стороны сердечно-сосудистой системы\u003Cbr\u003Eчастота неизвестна: сердечная недостаточность, повышение артериального давления, вазодилатация.\u003Cbr\u003EНарушения со стороны дыхательной системы\u003Cbr\u003Eредко: обострение бронхиальной астмы; частота неизвестна: бронхоспазм (в особенности, у пациентов с гиперчувствительностью к НПВП), ринит.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта\u003Cbr\u003Eчасто: тошнота, рвота, диспепсия, боль в области живота; нечасто: запор, диарея, вздутие живота, гастрит; редко: пептическая язва, стоматит; очень редко: обострение язвенного колита или болезни Крона, желудочно-кишечное кровотечение, перфорация.\u003Cbr\u003EНарушения со стороны печени и желчевыводяших путей\u003Cbr\u003Eредко: гепатит, повышение активности \"печеночных\" трансаминаз, повышение концентрации билирубина.\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей\u003Cbr\u003Eнечасто: кожная сыпь, кожный зуд; частота неизвестна: фотосенсибилизация, алопеция, крапивница, ангионевротический отек, эритема, буллезная сыпь, включая синдром Стивенса-Джонсона, токсический эпидермальный некролиз.\u003Cbr\u003EНарушения со стороны почек и мочевыводящих путей\u003Cbr\u003Eчастота неизвестна: острая почечная недостаточность, нефрит, интерстициальный нефритический синдром, нефротический синдром, аномальные значения показателей функции почек.\u003Cbr\u003EПрочее\u003Cbr\u003Eнечасто: отеки; редко: увеличение массы тела; частота неизвестна: повышенная утомляемость."},{"name":"Фармакологическое действие","value":"Кетопрофен является нестероидным противовоспалительным препаратом (НПВП). Кетопрофен обладает противовоспалительным, анальгезирующим и жаропонижающим действием.\u003Cbr\u003EКетопрофен блокирует действие фермента циклооксигеназы 1 и 2 (ЦОГ1 и ЦОГ2) и, частично, липооксигеназы, что приводит к подавлению синтеза простагландинов (в том числе и в центральной нервной системе (ЦНС), вероятнее всего, в гипоталамусе).\u003Cbr\u003EСтабилизирует in vitro и in vivo липосомальные мембраны, при высоких концентрациях in vitro кетопрофен подавляет синтез брадикинина и лейкотриенов.\u003Cbr\u003EКетопрофен не оказывает отрицательного влияния на состояние суставного хряща.\u003Cbr\u003E"},{"name":"Фармакологическая группа","value":"нестероидный противовоспалительный препарат (НПВП)"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-travm-boli-v-myshtsakh-i-sustavakh","categoryId":"15756903","navnodeId":"25542230","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 15 лет"},{"name":"Условия хранения","value":"Хранить при температуре не выше 25°С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Как и в случае других НПВП, при передозировке кетопрофена могут отмечаться тошнота, рвота, боль в животе, рвота с кровью, мелена, нарушение сознания, угнетение дыхания, судороги, нарушение функции почек и почечная недостаточность.\u003Cbr\u003EПри передозировке показано промывание желудка и применение активированного угля.\u003Cbr\u003EЛечение - симптоматическое; воздействие кетопрофена на желудочно-кишечный тракт можно ослабить с помощью средств, снижающих секрецию желез желудка (например, ингибиторов протонной помпы) и простагландинов."},{"name":"Применение при беременности и кормлении грудью","value":"Ингибирование синтеза простагландинов может оказать нежелательное влияние на течение беременности и/или на эмбриональное развитие. Данные, полученные в ходе эпидемиологических исследований при применении ингибиторов синтеза простагландина на ранних сроках беременности, подтверждают повышение риска самопроизвольного аборта и формирования пороков сердца (~1-1,5%).\u003Cbr\u003EПрименять препарат беременным женщинам в I и II триместрах беременности возможно только в случае, когда преимущества для матери оправдывают возможный риск для плода.\u003Cbr\u003EПротивопоказано применение кетопрофена у беременных женщин во время III триместра беременности из-за возможности развития слабости родовой активности матки и/или преждевременного закрытия артериального протока, возможного увеличения времени кровотечения, маловодия и почечной недостаточности.\u003Cbr\u003EНа сегодняшний момент отсутствуют данные о выделении кетопрофена в грудное молоко, поэтому при необходимости применения кетопрофена в период грудного вскармливания, следует решить вопрос о прекращении грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Данных об отрицательном влиянии препарата Кетонал® в рекомендуемых дозах на способность к управлению автомобилем или работу с механизмами нет.\u003Cbr\u003EВместе с тем, пациентам, у которых на фоне применения препарата возникают сонливость, головокружение или другие неприятные ощущения со стороны нервной системы, включая нарушение зрения, следует воздержаться от вождения автотранспорта и занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EБронхиальная астма в анамнезе, клинически выраженные сердечно-сосудистые, цереброваскулярные заболевания и заболевания периферических артерий, дислипидемия, прогрессирующие заболевания печени, печеночная недостаточность, гипербилирубинемия, алкогольный цирроз печени, почечная недостаточность (КК 30-60 мл/мин), хроническая сердечная недостаточность, артериальная гипертензия, заболевания крови, дегидратация, сахарный диабет, анамнестические данные о развитии язвенного поражения желудочно-кишечного тракта, наличие инфекции Helicobacter pilory, тяжелые соматические заболевания, пожилой возраст, курение, сопутствующая терапия антикоагулянтами (например, варфарин), антиагрегантами (например, ацетилсалициловая кислота), глюкокортикостероидами для приема внутрь (например, преднизолон), селективными ингибиторами обратного захвата серотонина (например, циталопрам, сертралин), длительное применение НПВП; пожилые пациенты, принимающие диуретики; пациенты с уменьшением объема циркулирующей крови.\u003Cbr\u003EНе следует сочетать прием кетопрофена с приемом других НПВП и/или ингибиторов ЦОГ2.\u003Cbr\u003EПри длительном применении НПВП необходимо периодически оценивать клинический анализ крови, контролировать функцию почек и печени, в особенности, у пациентов пожилого возраста (старше 65 лет), проводить анализ кала на скрытую кровь.\u003Cbr\u003EНеобходимо соблюдать осторожность и чаще контролировать артериальное давление при применении кетопрофена для лечения пациентов с артериальной гипертензией, сердечно-сосудистыми заболеваниями, которые приводят к задержке жидкости в организме.\u003Cbr\u003EПри возникновении нарушений со стороны органов зрения лечение следует незамедлительно прекратить.\u003Cbr\u003EКак и другие НПВП, кетопрофен может маскировать симптомы инфекционно-воспалительных заболеваний. В случае обнаружения признаков инфекции или ухудшения самочувствия на фоне применения препарата необходимо незамедлительно обратиться к врачу.\u003Cbr\u003EПри наличии в анамнезе противопоказаний со стороны ЖКТ (кровотечения, перфорация, язвенная болезнь), проведении длительной терапии и применении высоких доз кетопрофена пациент должен находиться под тщательным наблюдением врача.\u003Cbr\u003EИз-за важной роли простагландинов в поддержании почечного кровотока следует проявлять особую осторожность при применении кетопрофена пациентам с сердечной или почечной недостаточностью, а также при лечении пожилых пациентов, принимающих диуретики, и пациентов, у которых, по какой-либо причине, наблюдается уменьшение объема циркулирующей крови. Применение препарата должно быть прекращено перед большим хирургическим вмешательством.\u003Cbr\u003EПрименение кетопрофена может влиять на женскую фертильность, поэтому пациенткам с бесплодием (в т.ч. проходящим обследование) не рекомендуется применять препарат.\u003Cbr\u003E"},{"name":"Взаимодействие","value":"Кетопрофен может ослаблять действие диуретиков и гипотензивных средств и усиливать действие гипогликемических препаратов для приема внутрь и некоторых противосудорожных препаратов (фенитоин).\u003Cbr\u003EСовместное применение с другими НПВП, салицилатами, глюкокортикостероидами, этанолом повышает риск развития нежелательных явлений со стороны желудочно-кишечного тракта. Одновременное применение с антикоагулянтами (гепарин, варфарин), тромболитиками, антиагрегантами (тиклопидин, клопидогрел), пентоксифиллином повышает риск развития кровотечений.\u003Cbr\u003EОдновременное применение с солями калия, калийсберегающими диуретиками, ингибиторами АПФ, НПВП, низкомолекулярными гепаринами, циклоспорином, такролимусом и триметопримом повышает риск развития гиперкалиемии.\u003Cbr\u003EПовышает концентрацию в плазме крови сердечных гликозидов, блокаторов \"медленных\" кальциевых каналов, препаратов лития, циклоспорина, метотрексата и дигоксина.\u003Cbr\u003EУвеличивает токсичность метотрексата и нефротоксичность циклоспорина. Одновременное применение с пробенецидом значительно снижает клиренс кетопрофена в плазме крови.\u003Cbr\u003EСочетанное применение с глюкокортикостероидами и другими НПВП (включая селективные ингибиторы ЦОГ2) увеличивает вероятность возникновения побочных эффектов (в частности, со стороны желудочно-кишечного тракта).\u003Cbr\u003EНПВП могут уменьшать эффективность мифепристона. Прием НПВП следует начинать не ранее, чем через 8-12 дней после отмены мифепристона."},{"name":"Регистрационный номер","value":"П N013942/06"},{"name":"Дата государственной регистрации","value":"10.12.2021"},{"name":"Владелец регистрационного удостоверения","value":"Sandoz","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-travm-boli-v-myshtsakh-i-sustavakh","categoryId":"15756903","navnodeId":"25542230","glfilters":["34324371:35649313","7893318:15994436"]}}},{"name":"Изготовитель","value":"Новартис Нева"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Кетонал","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-travm-boli-v-myshtsakh-i-sustavakh","categoryId":"15756903","navnodeId":"25542230","glfilters":["17796364:18025404"]}}},{"name":"Срок годности","value":"3 г."}]}},"fullSpecsGrouped":{"14090180278541034422":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Назначение","value":"болевой синдром слабой и умеренной выраженности, болевой синдром средней и высокой интенсивности различной этиологии, головная боль, заболевания опорно-двигательного аппарата воспалительного характера, заболевания опорно-двигательного аппарата дегенеративного характера, зубная боль, менструальные боли"},{"name":"Показания к применению","value":"Симптоматическая терапия болезненных и воспалительных процессов различного происхождения, в том числе:\u003Cbr\u003E- воспалительные и дегенеративные заболевания опорно-двигательного аппарата:\u003Cbr\u003Eревматоидный артрит;\u003Cbr\u003Eсеронегативные артриты: анкилозирующий спондилоартрит - болезнь Бехтерева, псориатический артрит, реактивный артрит (синдром Рейтера);\u003Cbr\u003Eподагра, псевдоподагра;\u003Cbr\u003Eостеоартроз;\u003Cbr\u003Eтендинит, бурсит, миалгия, невралгия, радикулит;\u003Cbr\u003E- болевой синдром, в том числе слабый, умеренный и выраженный:\u003Cbr\u003Eголовная боль;\u003Cbr\u003Eзубная боль;\u003Cbr\u003Eпосттравматический и послеоперационный болевой синдром;\u003Cbr\u003Eболевой синдром при онкологических заболеваниях;\u003Cbr\u003Eальгодисменорея."},{"name":"Противопоказания","value":"- Гиперчувствительность к кетопрофену или другим компонентам препарата, а также салицилатам или другим НПВП;\u003Cbr\u003E- полное или неполное сочетание бронхиальной астмы, рецидивирующего полипоза носа и околоносовых пазух и непереносимости АСК или других НПВП (в т.ч. в анамнезе);\u003Cbr\u003E- ринит или крапивница в анамнезе, вызванные приемом ацетилсалициловой кислоты или других НПВП;\u003Cbr\u003E- язвенная болезнь желудка или двенадцатиперстной кишки в стадии обострения, язвенный колит, болезнь Крона;\u003Cbr\u003E- гемофилия и другие нарушения свертываемости крови;\u003Cbr\u003E- детский возраст (до 15 лет);\u003Cbr\u003E- тяжелая печеночная недостаточность;\u003Cbr\u003E- тяжелая почечная недостаточность (клиренс креатинина (КК) менее 30 мл/мин);\u003Cbr\u003E- декомпенсированная сердечная недостаточность;\u003Cbr\u003E- послеоперационный период после аортокоронарного шунтирования;\u003Cbr\u003E- желудочно-кишечные, цереброваскулярные и другие кровотечения (или подозрение на кровотечение);\u003Cbr\u003E- прогрессирующие заболевания почек, дивертикулит, активное заболевание печени, воспалительные заболевания кишечника, подтвержденная гиперкалиемия;\u003Cbr\u003E- непереносимость лактозы, дефицит лактазы, синдром глюкозо-галактозной мальабсорбции;\u003Cbr\u003E- хроническая диспепсия;\u003Cbr\u003E- III триместр беременности;\u003Cbr\u003E- период грудного вскармливания."},{"name":"Состав","value":"1 таблетка, покрытая пленочной оболочкой, содержит:\u003Cbr\u003Eядро\tтаблетки:\tДействующее\u003Cbr\u003Eвещество: кетопрофен - 100,000 мг; вспомогательные вещества: магния стеарат - 1,600 мг; кремния диоксид коллоидный безводный 1,200 мг; повидон К 25 - 5,000 мг; крахмал кукурузный - 44,200 мг; тальк - 8,000 мг; лактозы моногидрат - 60,000 мг.\u003Cbr\u003Eсостав\tпленочной\tоболочки: гипромеллоза (4,622 мг), макрогол 400 (0,940 мг), краситель\u003Cbr\u003Eиндигокармин Е 132 (0, 153 мг), титана диоксид (1,054 мг), тальк (0,281 мг), воск карнаубский (0,050 мг).\u003Cbr\u003E"},{"name":"Действующее вещество","value":"Кетопрофен"},{"name":"Способ применения и дозы","value":"Внутрь.\u003Cbr\u003EКетонал таблетки, покрытые пленочной оболочкой, 100 мг следует проглатывать целиком во время или после еды, запивая водой или молоком (объем жидкости должен быть не менее 100 мл).\u003Cbr\u003EОбычно препарат назначают по 1 таблетке 2 раза в день.\u003Cbr\u003EПрепараты для приема внутрь Кетонал можно сочетать с применением ректальных суппозиториев, например, пациент может принять 1 таблетку (100 мг) Кетонал утром и ввести 1 суппозиторий (100 мг) ректально вечером. Максимальная доза кетопрофена составляет 200 мг/сутки.\u003Cbr\u003EНе рекомендуется превышать максимальную суточную дозу препарата.\u003Cbr\u003EС целью снижения риска развития нежелательных явлений со стороны желудочно-кишечного тракта (ЖКТ), пациентам с факторами риска рекомендуется одновременно назначать прием ингибиторов протонной помпы."},{"name":"Побочные действия","value":"По данным Всемирной организации здравоохранения (ВОЗ) нежелательные эффекты классифицированы в соответствии с их частотой развития следующим образом: очень часто (≥1/10), часто (≥1/100, \u003C1/10), нечасто (≥1/1000, \u003C1/100), редко (≥1/10000, \u003C1/1000) и очень редко (\u003C1/10000); частота неизвестна (частоту возникновения явлений нельзя определить на основании имеющихся данных).\u003Cbr\u003EНарушения со стороны системы кроветворения и лимфатической системы\u003Cbr\u003Eредко: геморрагическая анемия; частота неизвестна: агранулоцитоз, тромбоцитопения, нарушение функции костного мозга.\u003Cbr\u003EНарушения со стороны иммунной системы\u003Cbr\u003Eчастота неизвестна: анафилактические реакции (включая анафилактический шок).\u003Cbr\u003EНарушения со стороны нервной системы\u003Cbr\u003Eнечасто: головная боль, головокружение, сонливость; редко: парестезии; частота неизвестна: судороги, нарушение вкусовых ощущений.\u003Cbr\u003EНарушения психики\u003Cbr\u003Eчастота неизвестна: эмоциональная лабильность.\u003Cbr\u003EНарушения со стороны органов чувств\u003Cbr\u003Eредко: нечеткость зрения, шум в ушах.\u003Cbr\u003EНарушения со стороны сердечно-сосудистой системы\u003Cbr\u003Eчастота неизвестна: сердечная недостаточность, повышение артериального давления, вазодилатация.\u003Cbr\u003EНарушения со стороны дыхательной системы\u003Cbr\u003Eредко: обострение бронхиальной астмы; частота неизвестна: бронхоспазм (в особенности, у пациентов с гиперчувствительностью к НПВП), ринит.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта\u003Cbr\u003Eчасто: тошнота, рвота, диспепсия, боль в области живота; нечасто: запор, диарея, вздутие живота, гастрит; редко: пептическая язва, стоматит; очень редко: обострение язвенного колита или болезни Крона, желудочно-кишечное кровотечение, перфорация.\u003Cbr\u003EНарушения со стороны печени и желчевыводяших путей\u003Cbr\u003Eредко: гепатит, повышение активности \"печеночных\" трансаминаз, повышение концентрации билирубина.\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей\u003Cbr\u003Eнечасто: кожная сыпь, кожный зуд; частота неизвестна: фотосенсибилизация, алопеция, крапивница, ангионевротический отек, эритема, буллезная сыпь, включая синдром Стивенса-Джонсона, токсический эпидермальный некролиз.\u003Cbr\u003EНарушения со стороны почек и мочевыводящих путей\u003Cbr\u003Eчастота неизвестна: острая почечная недостаточность, нефрит, интерстициальный нефритический синдром, нефротический синдром, аномальные значения показателей функции почек.\u003Cbr\u003EПрочее\u003Cbr\u003Eнечасто: отеки; редко: увеличение массы тела; частота неизвестна: повышенная утомляемость."},{"name":"Фармакологическое действие","value":"Кетопрофен является нестероидным противовоспалительным препаратом (НПВП). Кетопрофен обладает противовоспалительным, анальгезирующим и жаропонижающим действием.\u003Cbr\u003EКетопрофен блокирует действие фермента циклооксигеназы 1 и 2 (ЦОГ1 и ЦОГ2) и, частично, липооксигеназы, что приводит к подавлению синтеза простагландинов (в том числе и в центральной нервной системе (ЦНС), вероятнее всего, в гипоталамусе).\u003Cbr\u003EСтабилизирует in vitro и in vivo липосомальные мембраны, при высоких концентрациях in vitro кетопрофен подавляет синтез брадикинина и лейкотриенов.\u003Cbr\u003EКетопрофен не оказывает отрицательного влияния на состояние суставного хряща.\u003Cbr\u003E"},{"name":"Фармакологическая группа","value":"нестероидный противовоспалительный препарат (НПВП)"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 15 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Хранить при температуре не выше 25°С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Как и в случае других НПВП, при передозировке кетопрофена могут отмечаться тошнота, рвота, боль в животе, рвота с кровью, мелена, нарушение сознания, угнетение дыхания, судороги, нарушение функции почек и почечная недостаточность.\u003Cbr\u003EПри передозировке показано промывание желудка и применение активированного угля.\u003Cbr\u003EЛечение - симптоматическое; воздействие кетопрофена на желудочно-кишечный тракт можно ослабить с помощью средств, снижающих секрецию желез желудка (например, ингибиторов протонной помпы) и простагландинов."},{"name":"Применение при беременности и кормлении грудью","value":"Ингибирование синтеза простагландинов может оказать нежелательное влияние на течение беременности и/или на эмбриональное развитие. Данные, полученные в ходе эпидемиологических исследований при применении ингибиторов синтеза простагландина на ранних сроках беременности, подтверждают повышение риска самопроизвольного аборта и формирования пороков сердца (~1-1,5%).\u003Cbr\u003EПрименять препарат беременным женщинам в I и II триместрах беременности возможно только в случае, когда преимущества для матери оправдывают возможный риск для плода.\u003Cbr\u003EПротивопоказано применение кетопрофена у беременных женщин во время III триместра беременности из-за возможности развития слабости родовой активности матки и/или преждевременного закрытия артериального протока, возможного увеличения времени кровотечения, маловодия и почечной недостаточности.\u003Cbr\u003EНа сегодняшний момент отсутствуют данные о выделении кетопрофена в грудное молоко, поэтому при необходимости применения кетопрофена в период грудного вскармливания, следует решить вопрос о прекращении грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Данных об отрицательном влиянии препарата Кетонал® в рекомендуемых дозах на способность к управлению автомобилем или работу с механизмами нет.\u003Cbr\u003EВместе с тем, пациентам, у которых на фоне применения препарата возникают сонливость, головокружение или другие неприятные ощущения со стороны нервной системы, включая нарушение зрения, следует воздержаться от вождения автотранспорта и занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EБронхиальная астма в анамнезе, клинически выраженные сердечно-сосудистые, цереброваскулярные заболевания и заболевания периферических артерий, дислипидемия, прогрессирующие заболевания печени, печеночная недостаточность, гипербилирубинемия, алкогольный цирроз печени, почечная недостаточность (КК 30-60 мл/мин), хроническая сердечная недостаточность, артериальная гипертензия, заболевания крови, дегидратация, сахарный диабет, анамнестические данные о развитии язвенного поражения желудочно-кишечного тракта, наличие инфекции Helicobacter pilory, тяжелые соматические заболевания, пожилой возраст, курение, сопутствующая терапия антикоагулянтами (например, варфарин), антиагрегантами (например, ацетилсалициловая кислота), глюкокортикостероидами для приема внутрь (например, преднизолон), селективными ингибиторами обратного захвата серотонина (например, циталопрам, сертралин), длительное применение НПВП; пожилые пациенты, принимающие диуретики; пациенты с уменьшением объема циркулирующей крови.\u003Cbr\u003EНе следует сочетать прием кетопрофена с приемом других НПВП и/или ингибиторов ЦОГ2.\u003Cbr\u003EПри длительном применении НПВП необходимо периодически оценивать клинический анализ крови, контролировать функцию почек и печени, в особенности, у пациентов пожилого возраста (старше 65 лет), проводить анализ кала на скрытую кровь.\u003Cbr\u003EНеобходимо соблюдать осторожность и чаще контролировать артериальное давление при применении кетопрофена для лечения пациентов с артериальной гипертензией, сердечно-сосудистыми заболеваниями, которые приводят к задержке жидкости в организме.\u003Cbr\u003EПри возникновении нарушений со стороны органов зрения лечение следует незамедлительно прекратить.\u003Cbr\u003EКак и другие НПВП, кетопрофен может маскировать симптомы инфекционно-воспалительных заболеваний. В случае обнаружения признаков инфекции или ухудшения самочувствия на фоне применения препарата необходимо незамедлительно обратиться к врачу.\u003Cbr\u003EПри наличии в анамнезе противопоказаний со стороны ЖКТ (кровотечения, перфорация, язвенная болезнь), проведении длительной терапии и применении высоких доз кетопрофена пациент должен находиться под тщательным наблюдением врача.\u003Cbr\u003EИз-за важной роли простагландинов в поддержании почечного кровотока следует проявлять особую осторожность при применении кетопрофена пациентам с сердечной или почечной недостаточностью, а также при лечении пожилых пациентов, принимающих диуретики, и пациентов, у которых, по какой-либо причине, наблюдается уменьшение объема циркулирующей крови. Применение препарата должно быть прекращено перед большим хирургическим вмешательством.\u003Cbr\u003EПрименение кетопрофена может влиять на женскую фертильность, поэтому пациенткам с бесплодием (в т.ч. проходящим обследование) не рекомендуется применять препарат.\u003Cbr\u003E"},{"name":"Взаимодействие","value":"Кетопрофен может ослаблять действие диуретиков и гипотензивных средств и усиливать действие гипогликемических препаратов для приема внутрь и некоторых противосудорожных препаратов (фенитоин).\u003Cbr\u003EСовместное применение с другими НПВП, салицилатами, глюкокортикостероидами, этанолом повышает риск развития нежелательных явлений со стороны желудочно-кишечного тракта. Одновременное применение с антикоагулянтами (гепарин, варфарин), тромболитиками, антиагрегантами (тиклопидин, клопидогрел), пентоксифиллином повышает риск развития кровотечений.\u003Cbr\u003EОдновременное применение с солями калия, калийсберегающими диуретиками, ингибиторами АПФ, НПВП, низкомолекулярными гепаринами, циклоспорином, такролимусом и триметопримом повышает риск развития гиперкалиемии.\u003Cbr\u003EПовышает концентрацию в плазме крови сердечных гликозидов, блокаторов \"медленных\" кальциевых каналов, препаратов лития, циклоспорина, метотрексата и дигоксина.\u003Cbr\u003EУвеличивает токсичность метотрексата и нефротоксичность циклоспорина. 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Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

Где купить

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171 ₽

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    на основе 113 оценок
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  • Рейтинг товара: 5 из 5
    на основе 6 оценок
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  • Рейтинг товара: 4.8 из 5
    на основе 95 оценок
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  • Рейтинг товара: 5 из 5
    на основе 12 оценок
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  • Рейтинг товара: 5 из 5
    на основе 3 оценки
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  • Рейтинг товара: 4.8 из 5
    на основе 33 оценки
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  • Рейтинг товара: 4 из 5
    на основе 3 оценки
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  • Рейтинг товара: 5 из 5
    на основе 3 оценки
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  • Рейтинг товара: 5 из 5
    на основе 2 оценки
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  • Рейтинг товара: 4.9 из 5
    на основе 320 оценок
    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таб. п/о плен., 400 мг, 50 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Инструкция

Показания к применению

Симптоматическая терапия болезненных и воспалительных процессов различного происхождения, в том числе:
- воспалительные и дегенеративные заболевания опорно-двигательного аппарата:
ревматоидный артрит;
серонегативные артриты: анкилозирующий спондилоартрит - болезнь Бехтерева, псориатический артрит, реактивный артрит (синдром Рейтера);
подагра, псевдоподагра;
остеоартроз;
тендинит, бурсит, миалгия, невралгия, радикулит;
- болевой синдром, в том числе слабый, умеренный и выраженный:
головная боль;
зубная боль;
посттравматический и послеоперационный болевой синдром;
болевой синдром при онкологических заболеваниях;
альгодисменорея.

Противопоказания

- Гиперчувствительность к кетопрофену или другим компонентам препарата, а также салицилатам или другим НПВП;
- полное или неполное сочетание бронхиальной астмы, рецидивирующего полипоза носа и околоносовых пазух и непереносимости АСК или других НПВП (в т.ч. в анамнезе);
- ринит или крапивница в анамнезе, вызванные приемом ацетилсалициловой кислоты или других НПВП;
- язвенная болезнь желудка или двенадцатиперстной кишки в стадии обострения, язвенный колит, болезнь Крона;
- гемофилия и другие нарушения свертываемости крови;
- детский возраст (до 15 лет);
- тяжелая печеночная недостаточность;
- тяжелая почечная недостаточность (клиренс креатинина (КК) менее 30 мл/мин);
- декомпенсированная сердечная недостаточность;
- послеоперационный период после аортокоронарного шунтирования;
- желудочно-кишечные, цереброваскулярные и другие кровотечения (или подозрение на кровотечение);
- прогрессирующие заболевания почек, дивертикулит, активное заболевание печени, воспалительные заболевания кишечника, подтвержденная гиперкалиемия;
- непереносимость лактозы, дефицит лактазы, синдром глюкозо-галактозной мальабсорбции;
- хроническая диспепсия;
- III триместр беременности;
- период грудного вскармливания.

Способ применения и дозы

Внутрь.
Кетонал таблетки, покрытые пленочной оболочкой, 100 мг следует проглатывать целиком во время или после еды, запивая водой или молоком (объем жидкости должен быть не менее 100 мл).
Обычно препарат назначают по 1 таблетке 2 раза в день.
Препараты для приема внутрь Кетонал можно сочетать с применением ректальных суппозиториев, например, пациент может принять 1 таблетку (100 мг) Кетонал утром и ввести 1 суппозиторий (100 мг) ректально вечером. Максимальная доза кетопрофена составляет 200 мг/сутки.
Не рекомендуется превышать максимальную суточную дозу препарата.
С целью снижения риска развития нежелательных явлений со стороны желудочно-кишечного тракта (ЖКТ), пациентам с факторами риска рекомендуется одновременно назначать прием ингибиторов протонной помпы.
Полная инструкция
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Кетонал таб. п/о плен.
Кетонал таб. п/о плен., 100 мг, 20 шт.
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Инструкция

171 ₽

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5.0
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Заказывайте в новом приложении
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