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Описание

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Пирацетам капс., 200 мг, 60 шт.

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4.8
(5)
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Дозировка: 200 мг

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Коротко о товаре

Артикул Маркета
3123173861
Тип препарата
Назначение
Действующее вещество
Возраст
от 3 лет
Инструкция
{"widgets":{"@card/SpecsList":{"/content/page/fancyPage/productSpecsList":{"wrapperProps":{"margins":{"top":4,"bottom":4}},"specsLimit":5,"title":"Коротко о товаре","titleSize":"14","type":"minimal","offset":"s","isHealthCategory":true,"forceShowWidget":true,"withFridge":true}}},"meta":{"/content/page/fancyPage/productSpecsList":{"name":"@card/SpecsList"}},"collections":{"minimalSpecs":{"4976963640955096243":{"specItems":[{"name":"Артикул Маркета","value":"3123173861","withCopyValueButton":true},{"name":"тип препарата","value":"рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"назначение","value":"симптоматическое лечение интеллектуально-мнестических нарушений при отсутствии установленного диагноза деменции, уменьшение проявлений кортикальной миоклонии","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["36476390:36618421,36618258"]}}},{"name":"действующее вещество","value":"Пирацетам","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["27144131:28710700"]}}},{"name":"возраст","value":"от 3 лет"},{"name":"форма выпуска","value":"капсулы"},{"name":"страна-производитель","value":"Россия"}]}},"compactSpecs":{"4976963640955096243":{"specItems":[{"name":"Артикул Маркета","value":"3123173861","withCopyValueButton":true},{"name":"Тип препарата","value":"Рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"Действующее вещество","value":"Пирацетам","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["27144131:28710700"]}}},{"name":"Возраст","value":"От 3 лет"},{"name":"Форма выпуска","value":"Капсулы"}]}},"fullSpecs":{"4976963640955096243":{"specItems":[{"name":"Тип препарата","value":"лекарственный препарат","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["34324371:35649313"]}}},{"name":"Рецептурный препарат","value":"да","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["27272850:1,0"]}}},{"name":"Органы и системы","value":"нервная система"},{"name":"Назначение","value":"симптоматическое лечение интеллектуально-мнестических нарушений при отсутствии установленного диагноза деменции, уменьшение проявлений кортикальной миоклонии","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["36476390:36618421,36618258"]}}},{"name":"Показания к применению","value":"Симптоматическое лечение интеллектуально-мнестических нарушений при отсутствии установленного диагноза деменции.\u003Cbr\u003EУменьшение проявлений кортикальной миоклонии у чувствительных к пирацетаму пациентов как в качестве монотерапии, так и в составе комплексной терапии.\u003Cbr\u003EВ целях определения чувствительности к пирацетаму в конкретном случае может быть проведен пробный курс лечения."},{"name":"Противопоказания","value":"Индивидуальная непереносимость пирацетама или производных пирролидона, а также других компонентов препарата;\u003Cbr\u003EХорея Гентингтона;\u003Cbr\u003EОстрое нарушение мозгового кровообращения (геморрагический инсульт);\u003Cbr\u003EКонечная стадия почечной недостаточности (при клиренсе креатинина менее 20 мл/мин);\u003Cbr\u003EДетский возраст до 3 лет."},{"name":"Состав","value":"Дозировка 200 мг\u003Cbr\u003EАктивное вещество: пирацетам - 200 мг;\u003Cbr\u003EВспомогательные вещества: кроскармеллоза натрия - 6,0 мг, магния стеарат - 2,0 мг, повидон-К17 - 5,0 мг.\u003Cbr\u003EКапсулы твердые желатиновые № 2.\u003Cbr\u003EСостав корпуса капсулы: титана диоксид - 2,0 %, желатин до 100 %.\u003Cbr\u003EСостав крышечки капсулы: краситель железа оксид черный - 0,53 %, краситель железа оксид красный - 0,93 %, краситель железа оксид желтый - 0,2 %, титана диоксид - 0,3333 %, желатин до 100%.\u003Cbr\u003EДозировка 400 мг\u003Cbr\u003EАктивное вещество: пирацетам - 400 мг;\u003Cbr\u003EВспомогательные вещества: кроскармеллоза натрия - 12,0 мг, магния стеарат - 4,0 мг, повидон- К17- 10,0 мг.\u003Cbr\u003EКапсулы твердые желатиновые № 0.\u003Cbr\u003EСостав корпуса капсулы: титана диоксид - 2,0 %, желатин до 100 %.\u003Cbr\u003EСостав крышечки капсулы: краситель азорубин - 0,1445 %, краситель синий патентованный - 0,002 %, титана диоксид - 2,0 %, желатин до 100 %."},{"name":"Действующее вещество","value":"Пирацетам","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["27144131:28710700"]}}},{"name":"Способ применения и дозы","value":"Внутрь.\u003Cbr\u003EВо время приема пищи или натощак, запивая жидкостью.\u003Cbr\u003EПри расстройствах памяти, интеллектуальных нарушениях:\u003Cbr\u003E2,4 - 4,8 г/сутки в 2-3 приема.\u003Cbr\u003EЛечение кортикальной миоклонии:\u003Cbr\u003EЛечение начинают с дозы 7,2 г/сутки, каждые 3-4 дня дозу увеличивают на 4,8 г/сутки до достижения максимальной дозы 24 г/сутки в 2 -3 приема. Лечение продолжают на протяжении всего периода заболевания. Каждые б месяцев следует предпринимать попытки уменьшения дозы или отмены препарата, постепенно сокращая дозу на 1,2 г/сутки каждые 2 дня.\u003Cbr\u003EДозирование пациентам с нарушением функции почек:\u003Cbr\u003EДозу следует корректировать в зависимости от величины клиренса креатинина (КК):\u003Cbr\u003EКлиренс креатинина для мужчин можно рассчитать, исходя из концентрации сывороточного креатинина, по следующей формуле:\u003Cbr\u003EКК (мл/мин) = [140 - возраст (годы) х масса тела (кг)]/[72 х ККсыворот (мг/мл)]\u003Cbr\u003EКлиренс креатинина для женщин можно рассчитать, умножив полученное значение на коэффициент 0,85.\u003Cbr\u003EПожилым пациентам дозу корректируют при наличии почечной недостаточности, при длительной терапии необходим контроль функционального состояния почек.\u003Cbr\u003EДозирование пациентам с нарушением функции печени:\u003Cbr\u003EПациенты с нарушением функции печени в коррекции дозы не нуждаются. Пациентам с нарушением функции и почек, и печени дозирование осуществляется по схеме (см. раздел \"Дозирование пациентам с нарушением функции почек\")."},{"name":"Побочные действия","value":"Со стороны нервной системы: двигательная расторможенность, раздражительность, сонливость, депрессия, астения, головная боль, бессонница, возбуждение, нарушение равновесия, атаксия, обострение течения эпилепсии, тревога, галлюцинации, спутанность сознания.\u003Cbr\u003EСо стороны пищеварительной системы: тошнота, рвота, диарея, боли в животе (в том числе гастралгия).\u003Cbr\u003EСо стороны репродуктивной системы: повышение сексуального влечения.\u003Cbr\u003EСо стороны обмена веществ: увеличение массы тела.\u003Cbr\u003EСо стороны органов слуха: вертиго.\u003Cbr\u003EСо стороны кожных покровов: дерматит, зуд, крапивница.\u003Cbr\u003EАллергические реакции: ангионевротический отек, гиперчувствительность, анафилактические реакции."},{"name":"Фармакологическое действие","value":"Активным компонентом является пирацетам, циклическое производное гамма-аминомасляной кислоты (ГАМК).\u003Cbr\u003EИмеющиеся данные свидетельствуют, что основной механизм действия пирацетама не является клеточноспецифичным или органоспецифичным.\u003Cbr\u003EПирацетам связывается с полярными головками фосфолипидов и образует мобильные комплексы препарат-фосфолипид. В результате восстанавливается двухслойная структура клеточной мембраны и ее стабильность, что в свою очередь, приводит к восстановлению трехмерной структуры мембранных и трансмембранных белков и восстановлению их функции.\u003Cbr\u003EНа нейрональном уровне пирацетам облегчает различные типы синаптической передачи, оказывая преимущественное воздействие на плотность и активность постсинаптических рецепторов (данные получены в исследованиях на животных). Пирацетам улучшает такие функции как обучение, память, внимание и сознание, не оказывая седативного или психостимулирующего воздействия.\u003Cbr\u003EГемореологические эффекты пирацетама связаны с его влиянием на эритроциты, тромбоциты и стенку сосудов.\u003Cbr\u003EУ пациентов с серповидно-клеточной анемией пирацетам увеличивает способность эритроцитов к деформации, снижает вязкость крови и предотвращает формирование \"монетных столбиков\". Кроме того, он снижает агрегацию тромбоцитов, не оказывая существенного влияния на их количество.\u003Cbr\u003EВ исследованиях на животных показано, что пирацетам тормозит спазм сосудов и противодействует различным вазоспастическим веществам.\u003Cbr\u003EВ исследованиях на здоровых добровольцах пирацетам снижал адгезию эритроцитов к эндотелию сосудов и стимулировал выработку простациклинов здоровым эндотелием."},{"name":"Фармакологическая группа","value":"ноотропы"},{"name":"Форма выпуска","value":"капсулы"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 3 лет"},{"name":"Условия хранения","value":"В защищенном от света месте при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы: диарея с примесью крови, боль в области живота.\u003Cbr\u003EЛечение: при значительной передозировке следует промыть желудок или вызвать рвоту. Рекомендуется проведение симптоматической терапии, которая может включать гемодиализ. Специфического антидота нет. Эффективность гемодиализа для пирацетама составляет 50-60%."},{"name":"Применение при беременности и кормлении грудью","value":"Контролируемых исследований применения препарата во время беременности не проводилось. Исследования на животных не показали прямого или опосредованного влияния на беременность, развитие эмбриона/плода, роды или постнатальное развитие. Пирацетам проникает через плацентарный барьер и в грудное молоко. Плазменная концентрация пирацетама у новорожденных достигает 70-90 % от таковой у матери. Пирацетам не должен назначаться во время беременности. В период лактации следует решить вопрос о прекращении грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения следует соблюдать осторожность при вождении автотранспорта и занятии другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"При лечении кортикальной миоклонии следует избегать резкого прерывания лечения, так как это может вызвать возобновление приступов.\u003Cbr\u003EПроникает через фильтрующие мембраны аппаратов для гемодиализа."},{"name":"Взаимодействие","value":"Возможность изменения фармакокинетики пирацетама под воздействием других лекарственных препаратов низкая, т.к. 90% пирацетама выводится в неизмененном виде почками.\u003Cbr\u003EПри одновременном применении с гормонами щитовидной железы отмечены сообщения о спутанности сознания, раздражительности и нарушении сна.\u003Cbr\u003EСогласно опубликованному исследованию у пациентов с рецидивирующим венозным тромбозом пирацетам в дозе 9,6 г/сутки повышает эффективность непрямых антикоагулянтов (отмечалось более выраженное снижение уровня агрегации тромбоцитов, уровня фибриногена, факторов Виллебранда, вязкости крови и плазмы по сравнению с применением только непрямых антикоагулянтов).\u003Cbr\u003EIn vitro пирацетам не угнетает изоферменты цитохрома Р450, такие как CYP1A2, 2В6, 2С8, 2С9, 2С19, 2В6, 2Е1 и 4А9/11 в концентрации 142, 426 и 1422 мкг/мл. При концентрации 1422 мкг/мл отмечено небольшое угнетение CYP2A6 (21%) и ЗА4/5 (11%), однако уровень Ki этих двух изоферментов достаточен при превышении 1422 мкг/мл, в связи с чем метаболическое взаимодействие с другими препаратами маловероятно.\u003Cbr\u003EПрием пирацетама в дозе 20 г/сутки в течение 4 недель не изменял максимальную концентрацию в сыворотке и площадь под кривой \"концентрация - время\" противоэпилептических препаратов (карбамазепина, фенитоина, фенобарбитала, вальпроевой кислоты).\u003Cbr\u003EСовместный прием с алкоголем не влиял на концентрацию пирацетама в сыворотке; концентрация этанола в сыворотке крови не изменялась при приеме 1,6 г пирацетама."},{"name":"Регистрационный номер","value":"ЛП-002415"},{"name":"Дата государственной регистрации","value":"03.04.2019"},{"name":"Владелец регистрационного удостоверения","value":"Атолл","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["34324371:35649313","7893318:17601668"]}}},{"name":"Изготовитель","value":"ОЗОН"},{"name":"Фасовщик","value":"ОЗОН"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Пирацетам","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["17796364:18023092"]}}},{"name":"Срок годности","value":"1 г."}]}},"fullSpecsGrouped":{"4976963640955096243":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"нервная система"},{"name":"Назначение","value":"симптоматическое лечение интеллектуально-мнестических нарушений при отсутствии установленного диагноза деменции, уменьшение проявлений кортикальной миоклонии"},{"name":"Показания к применению","value":"Симптоматическое лечение интеллектуально-мнестических нарушений при отсутствии установленного диагноза деменции.\u003Cbr\u003EУменьшение проявлений кортикальной миоклонии у чувствительных к пирацетаму пациентов как в качестве монотерапии, так и в составе комплексной терапии.\u003Cbr\u003EВ целях определения чувствительности к пирацетаму в конкретном случае может быть проведен пробный курс лечения."},{"name":"Противопоказания","value":"Индивидуальная непереносимость пирацетама или производных пирролидона, а также других компонентов препарата;\u003Cbr\u003EХорея Гентингтона;\u003Cbr\u003EОстрое нарушение мозгового кровообращения (геморрагический инсульт);\u003Cbr\u003EКонечная стадия почечной недостаточности (при клиренсе креатинина менее 20 мл/мин);\u003Cbr\u003EДетский возраст до 3 лет."},{"name":"Состав","value":"Дозировка 200 мг\u003Cbr\u003EАктивное вещество: пирацетам - 200 мг;\u003Cbr\u003EВспомогательные вещества: кроскармеллоза натрия - 6,0 мг, магния стеарат - 2,0 мг, повидон-К17 - 5,0 мг.\u003Cbr\u003EКапсулы твердые желатиновые № 2.\u003Cbr\u003EСостав корпуса капсулы: титана диоксид - 2,0 %, желатин до 100 %.\u003Cbr\u003EСостав крышечки капсулы: краситель железа оксид черный - 0,53 %, краситель железа оксид красный - 0,93 %, краситель железа оксид желтый - 0,2 %, титана диоксид - 0,3333 %, желатин до 100%.\u003Cbr\u003EДозировка 400 мг\u003Cbr\u003EАктивное вещество: пирацетам - 400 мг;\u003Cbr\u003EВспомогательные вещества: кроскармеллоза натрия - 12,0 мг, магния стеарат - 4,0 мг, повидон- К17- 10,0 мг.\u003Cbr\u003EКапсулы твердые желатиновые № 0.\u003Cbr\u003EСостав корпуса капсулы: титана диоксид - 2,0 %, желатин до 100 %.\u003Cbr\u003EСостав крышечки капсулы: краситель азорубин - 0,1445 %, краситель синий патентованный - 0,002 %, титана диоксид - 2,0 %, желатин до 100 %."},{"name":"Действующее вещество","value":"Пирацетам"},{"name":"Способ применения и дозы","value":"Внутрь.\u003Cbr\u003EВо время приема пищи или натощак, запивая жидкостью.\u003Cbr\u003EПри расстройствах памяти, интеллектуальных нарушениях:\u003Cbr\u003E2,4 - 4,8 г/сутки в 2-3 приема.\u003Cbr\u003EЛечение кортикальной миоклонии:\u003Cbr\u003EЛечение начинают с дозы 7,2 г/сутки, каждые 3-4 дня дозу увеличивают на 4,8 г/сутки до достижения максимальной дозы 24 г/сутки в 2 -3 приема. Лечение продолжают на протяжении всего периода заболевания. Каждые б месяцев следует предпринимать попытки уменьшения дозы или отмены препарата, постепенно сокращая дозу на 1,2 г/сутки каждые 2 дня.\u003Cbr\u003EДозирование пациентам с нарушением функции почек:\u003Cbr\u003EДозу следует корректировать в зависимости от величины клиренса креатинина (КК):\u003Cbr\u003EКлиренс креатинина для мужчин можно рассчитать, исходя из концентрации сывороточного креатинина, по следующей формуле:\u003Cbr\u003EКК (мл/мин) = [140 - возраст (годы) х масса тела (кг)]/[72 х ККсыворот (мг/мл)]\u003Cbr\u003EКлиренс креатинина для женщин можно рассчитать, умножив полученное значение на коэффициент 0,85.\u003Cbr\u003EПожилым пациентам дозу корректируют при наличии почечной недостаточности, при длительной терапии необходим контроль функционального состояния почек.\u003Cbr\u003EДозирование пациентам с нарушением функции печени:\u003Cbr\u003EПациенты с нарушением функции печени в коррекции дозы не нуждаются. Пациентам с нарушением функции и почек, и печени дозирование осуществляется по схеме (см. раздел \"Дозирование пациентам с нарушением функции почек\")."},{"name":"Побочные действия","value":"Со стороны нервной системы: двигательная расторможенность, раздражительность, сонливость, депрессия, астения, головная боль, бессонница, возбуждение, нарушение равновесия, атаксия, обострение течения эпилепсии, тревога, галлюцинации, спутанность сознания.\u003Cbr\u003EСо стороны пищеварительной системы: тошнота, рвота, диарея, боли в животе (в том числе гастралгия).\u003Cbr\u003EСо стороны репродуктивной системы: повышение сексуального влечения.\u003Cbr\u003EСо стороны обмена веществ: увеличение массы тела.\u003Cbr\u003EСо стороны органов слуха: вертиго.\u003Cbr\u003EСо стороны кожных покровов: дерматит, зуд, крапивница.\u003Cbr\u003EАллергические реакции: ангионевротический отек, гиперчувствительность, анафилактические реакции."},{"name":"Фармакологическое действие","value":"Активным компонентом является пирацетам, циклическое производное гамма-аминомасляной кислоты (ГАМК).\u003Cbr\u003EИмеющиеся данные свидетельствуют, что основной механизм действия пирацетама не является клеточноспецифичным или органоспецифичным.\u003Cbr\u003EПирацетам связывается с полярными головками фосфолипидов и образует мобильные комплексы препарат-фосфолипид. В результате восстанавливается двухслойная структура клеточной мембраны и ее стабильность, что в свою очередь, приводит к восстановлению трехмерной структуры мембранных и трансмембранных белков и восстановлению их функции.\u003Cbr\u003EНа нейрональном уровне пирацетам облегчает различные типы синаптической передачи, оказывая преимущественное воздействие на плотность и активность постсинаптических рецепторов (данные получены в исследованиях на животных). Пирацетам улучшает такие функции как обучение, память, внимание и сознание, не оказывая седативного или психостимулирующего воздействия.\u003Cbr\u003EГемореологические эффекты пирацетама связаны с его влиянием на эритроциты, тромбоциты и стенку сосудов.\u003Cbr\u003EУ пациентов с серповидно-клеточной анемией пирацетам увеличивает способность эритроцитов к деформации, снижает вязкость крови и предотвращает формирование \"монетных столбиков\". Кроме того, он снижает агрегацию тромбоцитов, не оказывая существенного влияния на их количество.\u003Cbr\u003EВ исследованиях на животных показано, что пирацетам тормозит спазм сосудов и противодействует различным вазоспастическим веществам.\u003Cbr\u003EВ исследованиях на здоровых добровольцах пирацетам снижал адгезию эритроцитов к эндотелию сосудов и стимулировал выработку простациклинов здоровым эндотелием."},{"name":"Фармакологическая группа","value":"ноотропы"},{"name":"Форма выпуска","value":"капсулы"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 3 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"В защищенном от света месте при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы: диарея с примесью крови, боль в области живота.\u003Cbr\u003EЛечение: при значительной передозировке следует промыть желудок или вызвать рвоту. Рекомендуется проведение симптоматической терапии, которая может включать гемодиализ. Специфического антидота нет. Эффективность гемодиализа для пирацетама составляет 50-60%."},{"name":"Применение при беременности и кормлении грудью","value":"Контролируемых исследований применения препарата во время беременности не проводилось. Исследования на животных не показали прямого или опосредованного влияния на беременность, развитие эмбриона/плода, роды или постнатальное развитие. Пирацетам проникает через плацентарный барьер и в грудное молоко. Плазменная концентрация пирацетама у новорожденных достигает 70-90 % от таковой у матери. Пирацетам не должен назначаться во время беременности. В период лактации следует решить вопрос о прекращении грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения следует соблюдать осторожность при вождении автотранспорта и занятии другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"При лечении кортикальной миоклонии следует избегать резкого прерывания лечения, так как это может вызвать возобновление приступов.\u003Cbr\u003EПроникает через фильтрующие мембраны аппаратов для гемодиализа."},{"name":"Взаимодействие","value":"Возможность изменения фармакокинетики пирацетама под воздействием других лекарственных препаратов низкая, т.к. 90% пирацетама выводится в неизмененном виде почками.\u003Cbr\u003EПри одновременном применении с гормонами щитовидной железы отмечены сообщения о спутанности сознания, раздражительности и нарушении сна.\u003Cbr\u003EСогласно опубликованному исследованию у пациентов с рецидивирующим венозным тромбозом пирацетам в дозе 9,6 г/сутки повышает эффективность непрямых антикоагулянтов (отмечалось более выраженное снижение уровня агрегации тромбоцитов, уровня фибриногена, факторов Виллебранда, вязкости крови и плазмы по сравнению с применением только непрямых антикоагулянтов).\u003Cbr\u003EIn vitro пирацетам не угнетает изоферменты цитохрома Р450, такие как CYP1A2, 2В6, 2С8, 2С9, 2С19, 2В6, 2Е1 и 4А9/11 в концентрации 142, 426 и 1422 мкг/мл. При концентрации 1422 мкг/мл отмечено небольшое угнетение CYP2A6 (21%) и ЗА4/5 (11%), однако уровень Ki этих двух изоферментов достаточен при превышении 1422 мкг/мл, в связи с чем метаболическое взаимодействие с другими препаратами маловероятно.\u003Cbr\u003EПрием пирацетама в дозе 20 г/сутки в течение 4 недель не изменял максимальную концентрацию в сыворотке и площадь под кривой \"концентрация - время\" противоэпилептических препаратов (карбамазепина, фенитоина, фенобарбитала, вальпроевой кислоты).\u003Cbr\u003EСовместный прием с алкоголем не влиял на концентрацию пирацетама в сыворотке; концентрация этанола в сыворотке крови не изменялась при приеме 1,6 г пирацетама."},{"name":"Регистрационный номер","value":"ЛП-002415"},{"name":"Дата государственной регистрации","value":"03.04.2019"},{"name":"Владелец регистрационного удостоверения","value":"Атолл"},{"name":"Изготовитель","value":"ОЗОН"},{"name":"Фасовщик","value":"ОЗОН"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Пирацетам"},{"name":"Срок годности","value":"1 г."}]}],"transitionId":"tr_7061188203751116094"}}}}
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Ещё может подойти

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Инструкция

Показания к применению

Симптоматическое лечение интеллектуально-мнестических нарушений при отсутствии установленного диагноза деменции.
Уменьшение проявлений кортикальной миоклонии у чувствительных к пирацетаму пациентов как в качестве монотерапии, так и в составе комплексной терапии.
В целях определения чувствительности к пирацетаму в конкретном случае может быть проведен пробный курс лечения.

Противопоказания

Индивидуальная непереносимость пирацетама или производных пирролидона, а также других компонентов препарата;
Хорея Гентингтона;
Острое нарушение мозгового кровообращения (геморрагический инсульт);
Конечная стадия почечной недостаточности (при клиренсе креатинина менее 20 мл/мин);
Детский возраст до 3 лет.

Способ применения и дозы

Внутрь.
Во время приема пищи или натощак, запивая жидкостью.
При расстройствах памяти, интеллектуальных нарушениях:
2,4 - 4,8 г/сутки в 2-3 приема.
Лечение кортикальной миоклонии:
Лечение начинают с дозы 7,2 г/сутки, каждые 3-4 дня дозу увеличивают на 4,8 г/сутки до достижения максимальной дозы 24 г/сутки в 2 -3 приема. Лечение продолжают на протяжении всего периода заболевания. Каждые б месяцев следует предпринимать попытки уменьшения дозы или отмены препарата, постепенно сокращая дозу на 1,2 г/сутки каждые 2 дня.
Дозирование пациентам с нарушением функции почек:
Дозу следует корректировать в зависимости от величины клиренса креатинина (КК):
Клиренс креатинина для мужчин можно рассчитать, исходя из концентрации сывороточного креатинина, по следующей формуле:
КК (мл/мин) = [140 - возраст (годы) х масса тела (кг)]/[72 х ККсыворот (мг/мл)]
Клиренс креатинина для женщин можно рассчитать, умножив полученное значение на коэффициент 0,85.
Пожилым пациентам дозу корректируют при наличии почечной недостаточности, при длительной терапии необходим контроль функционального состояния почек.
Дозирование пациентам с нарушением функции печени:
Пациенты с нарушением функции печени в коррекции дозы не нуждаются. Пациентам с нарушением функции и почек, и печени дозирование осуществляется по схеме (см. раздел "Дозирование пациентам с нарушением функции почек").
Полная инструкция
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Пирацетам капс.
Пирацетам капс., 200 мг, 60 шт.
4.8
(5)
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2 вопроса
Инструкция

106 ₽

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4.8
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