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Толперизон органика таб. п/о плен., 50 мг, 30 шт.

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4.8
(12)
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Дозировка: 50 мг

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Коротко о товаре

Артикул Маркета
3622966192
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
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50,00 мг или 150,00 мг;\u003Cbr\u003Eвспомогательные вещества: лактозы моногидрат - 48,50 мг или 145,50 мг, крахмал кукурузный - 28,96 мг или 86,88 мг, целлюлоза микрокристаллическая тип 101 - 14,00 мг или 42,00 мг, лимонной кислоты моногидрат - 0,73 мг или 2,19 мг, тальк - 4,50 мг или 13,50 мг, стеариновая кислота -1,31 мг или 3,93 мг, кремния диоксид коллоидный (аэросил) - 0,80 мг или 2,40 мг, гипромеллоза (гидроксипропилметилцеллюлоза) 2910 тип 606 - 1,20 мг или 3,60 мг;\u003Cbr\u003Eсостав оболочки: опадрай II белый (серия 30F28359) - 5,00 мг или 10,00 мг или другая пленкообразующая система с указанным составом: (гипромеллоза (гидроксипропилметилцеллюлоза) 2910 - 2,00 мг или 4,00 мг, титана диоксид - 1,25 мг или 2,50 мг, полиэтиленгликоль (макрогол) - 0,80 мг или 1,60 мг, лактозы моногидрат - 0,65 мг или 1,30 мг, триацетин - 0,30 мг или 0,60 мг)."},{"name":"Действующее вещество","value":"Толперизон","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-travm-boli-v-myshtsakh-i-sustavakh","categoryId":"15756903","navnodeId":"25542230","glfilters":["27144131:28710499"]}}},{"name":"Способ применения и дозы","value":"Внутрь, после еды, не разжевывая, не разламывая таблетку, запивая небольшим количеством воды. Биодоступность толперизона снижается при приеме натощак.\u003Cbr\u003EПо 50 мг 3 раза в день, постепенно повышая дозу до 150 мг 3 раза в день.\u003Cbr\u003EПациенты с почечной недостаточностью\u003Cbr\u003EОпыт применения толперизона у пациентов с почечной недостаточностью ограничен, у данной категории пациентов чаще возникали нежелательные реакции, поэтому у пациентов с нарушениями функции почек средней степени необходимо проводить подбор дозы толперизона с тщательным наблюдением за состоянием здоровья пациента и контролем функции почек. При тяжелом поражении почек назначение толперизона не рекомендуется.\u003Cbr\u003EПациенты с печеночной недостаточностью\u003Cbr\u003EОпыт применения толперизона у пациентов с печеночной недостаточностью ограничен. У данной категории пациентов чаще возникали нежелательные реакции, поэтому у пациентов с нарушениями функции печени средней степени необходимо проводить подбор дозы толперизона с тщательным наблюдением за состоянием здоровья пациента и контролем функции печени. При тяжелых поражениях печени назначение толперизона не рекомендуется."},{"name":"Побочные действия","value":"Профиль безопасности толперизона подтверждается данными применения более чем у 12000 пациентов. Согласно этим данным, наиболее часто описаны нарушения со стороны кожи и подкожных тканей, общие, неврологические и желудочно-кишечные расстройства.\u003Cbr\u003EВ пострегистрационный период использования толперизона количество полученных сообщений о развитии реакций гиперчувствительности, связанных с применением толперизона, составляло около 50 - 60 % всех полученных сообщений. В большинстве случаев это были несерьезные побочные реакции. Об угрожающих жизни аллергических реакциях сообщалось очень редко.\u003Cbr\u003EЧастота побочных явлений классифицирована согласно рекомендациям Всемирной организации здравоохранения: очень часто (≥ 1/10), часто (≥ 1/100, \u003C 1/10), нечасто (≥ 1/1000, \u003C 1/100), редко (≥ 1/10000, \u003C 1/1000), очень редко (\u003C 1/10000), частота неизвестна (частоту возникновения нежелательных реакций невозможно оценить на основании имеющихся данных).\u003Cbr\u003EНарушения со стороны крови и лимфатической системы: очень редко - анемия, лимфаденопатия.\u003Cbr\u003EНарушения со стороны иммунной системы: редко - реакции гиперчувствительности*, анафилактические реакции; очень редко - анафилактический шок.\u003Cbr\u003EНарушения метаболизма и питания: нечасто - анорексия; очень редко - полидипсия.\u003Cbr\u003EПсихические нарушения: нечасто - нарушение сна, бессонница; редко - слабость, депрессия; очень редко - спутанность сознания.\u003Cbr\u003EНарушения со стороны нервной системы: нечасто головная боль, головокружение, сонливость; редко - синдром дефицита внимания, тремор, эпилепсия, парестезия, судороги, недомогание, летаргия.\u003Cbr\u003EНарушения со стороны органа зрения: редко - снижение остроты зрения.\u003Cbr\u003EНарушения со стороны органа слуха и лабиринта: редко - шум в ушах, вертиго.\u003Cbr\u003EНарушения со стороны сердца: редко - стенокардия, тахикардия, ощущение сердцебиения; очень редко - брадикардия.\u003Cbr\u003EНарушения со стороны сосудов: нечасто - артериальная гипотензия; редко - «приливы» крови к лицу.\u003Cbr\u003EНарушения со стороны дыхательной системы, органов грудной клетки и средостения: редко - одышка, носовое кровотечение, тахипноэ.\u003Cbr\u003EЖелудочно-кишечные нарушения: нечасто - дискомфорт в животе, диспепсия, диарея, сухость во рту, тошнота; редко - боль в эпигастрии, запор, метеоризм, рвота.\u003Cbr\u003EНарушения со стороны печени и желчевыводящих путей: редко - печеночная недостаточность средней степени.\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей: редко - аллергический дерматит, гипергидроз, кожный зуд, кожная сыпь, крапивница.\u003Cbr\u003EНарушения со стороны мышечной, скелетной и соединительной ткани: нечасто - боль в мышцах, мышечная слабость, боль в конечностях; редко - дискомфорт в конечностях; очень редко - остеопения.\u003Cbr\u003EНарушения со стороны почек и мочевыводящих путей: редко - энурез, протеинурия.\u003Cbr\u003EОбщие нарушения и реакции в месте введения: нечасто - астения, чувство усталости, недомогания; редко - ощущение опьянения, ощущение тепла, раздражительность, жажда; очень редко - дискомфорт в грудной клетке.\u003Cbr\u003EЛабораторные и инструментальные данные: редко - гипербилирубинемия, нарушение функции печени, тромбоцитопения, лейкоцитоз; очень редко - гиперкреатининемия.\u003Cbr\u003E* В рамках пострегистрационного мониторинга сообщалось об ангионевротическом отеке, включая отек лица и губ (частота неизвестна).\u003Cbr\u003EВажно сообщать о подозреваемых нежелательных реакциях с целью обеспечения непрерывного мониторинга отношения пользы и риска лекарственного препарата. Если у Вас возникли какие - либо нежелательные реакции, обратитесь к лечащему врачу, работнику аптеки или производителю. Медицинским работникам рекомендуется сообщать о любых подозреваемых нежелательных реакциях лекарственного препарата через национальные системы сообщения о нежелательных реакциях."},{"name":"Фармакологическое действие","value":"Миорелаксант центрального действия. Механизм действия полностью не выяснен. Толперизон обладает высокой аффинностью к нервной ткани, достигая наибольших концентраций в стволе головного мозга, спинном мозге и периферической нервной системе. Основной эффект толперизона опосредован торможением спинальных рефлекторных дуг. Вероятно, этот эффект совместно с устранением облегчения проведения возбуждения по нисходящим путям обеспечивает терапевтическое воздействие толперизона. Химическая структура толперизона схожа со структурой лидокаина. Подобно лидокаину, толперизон обладает мембраностабилизирующим действием и снижает электрическую возбудимость двигательных нейронов и первичных афферентных волокон. Толперизон дозозависимо тормозит активность потенциалзависимых натриевых каналов. Соответственно, снижается амплитуда и частота потенциала действия. Также был доказан угнетающий эффект на потенциалзависимые кальциевые каналы. Предполагается, что в дополнение к его мембраностабилизирующему действию толперизон может также тормозить выброс медиатора. Толперизон обладает некоторыми слабыми свойствами α-адренергических антагонистов и антимускариновым действием."},{"name":"Фармакологическая группа","value":"миорелаксант центрального действия"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-travm-boli-v-myshtsakh-i-sustavakh","categoryId":"15756903","navnodeId":"25542230","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"При температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Данные о передозировке толперизона немногочисленные.\u003Cbr\u003EВ доклинических исследованиях острой токсичности высокие дозы толперизона вызывали атаксию, тонико-клонические судороги, одышку и дыхательный паралич.\u003Cbr\u003EТолперизон не имеет специфического антидота. При передозировке рекомендуется симптоматическое и поддерживающее лечение."},{"name":"Применение при беременности и кормлении грудью","value":"Беременность\u003Cbr\u003EВ экспериментальных исследованиях на животных не выявлено тератогенного действия толперизона. По причине отсутствия значимых клинических данных толперизон не следует применять при беременности (особенно в 1 триместре), за исключением случаев, когда ожидаемая польза определенно оправдывает потенциальный риск для плода.\u003Cbr\u003EПериод грудного вскармливания\u003Cbr\u003EПоскольку данные о выделении толперизона с грудным молоком отсутствуют, то его применение в период кормления грудью противопоказано."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"При приеме толперизона возможно развитие побочных эффектов (головокружение, сонливость), поэтому следует соблюдать осторожность при управлении транспортными средствами и выполнении работ, требующих повышенной концентрации внимания."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EПрепарат следует применять с осторожностью у женщин, пациентов с гиперчувствительностью к лидокаину и/или другим препаратам или с аллергией в анамнезе (см. раздел «Особые указания»), у пациентов с почечной и печеночной недостаточностью (см. раздел «Способ применения и дозы»).\u003Cbr\u003EЕсли у Вас имеется какое - либо из вышеперечисленных состояний/заболеваний перед приемом препарата обязательно проконсультируйтесь с врачом.\u003Cbr\u003EНаиболее частыми нежелательными реакциями являются реакции гиперчувствительности. Аллергические реакции проявляются от легких кожных до тяжелых системных, включая анафилактический шок. Симптомы аллергических реакций: покраснение, сыпь, крапивница, зуд, ангионевротический отек (отек Квинке), тахикардия, артериальная гипотензия, одышка.\u003Cbr\u003EПациенты женского пола с реакциями гиперчувствительности к другим препаратам или аллергическими реакциями в анамнезе подвержены более высокому риску.\u003Cbr\u003EВ случае известной гиперчувствительности к лидокаину при применении толперизона следует соблюдать повышенную осторожность из-за возможных перекрестных реакций. Пациентам следует быть внимательными в отношении любых симптомов гиперчувствительности. Если возникли симптомы, то следует немедленно прекратить прием толперизона и немедленно обратиться к врачу.\u003Cbr\u003EНе следует повторно назначать толперизон после эпизода гиперчувствительности к лекарственному препарату, его содержащему."},{"name":"Взаимодействие","value":"Исследования фармакокинетического лекарственного взаимодействия с маркерным субстратом изофермента CYP2D6 декстрометорфаном показали, что одновременное применение толперизона может повысить содержание в крови лекарственных средств, которые метаболизируются преимущественно изоферментом CYP2D6 (тиоридазон, толтеродин, венлафаксин, атомоксетин, дезипрамин, декстрометорфан, метопролол, небиволол, перфеназин).\u003Cbr\u003EВ лабораторных экспериментах на микросомах печени человека и гепатоцитах человека значительного ингибирования или индукции других изоферментов CYP (CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP1A2, CYP3A4) не обнаружено.\u003Cbr\u003EВ связи с разнообразием метаболических путей толперизона повышение экспозиции толперизона при одновременном применении субстратов изофермента CYP2D6 и (или) других препаратов не ожидается.\u003Cbr\u003EБиодоступность толперизона снижается при приеме натощак.\u003Cbr\u003EНесмотря на то, что толперизон является препаратом центрального действия, седативный эффект его очень низкий. При одновременном применении с другими миорелаксантами центрального действия дозу толперизона следует уменьшать.\u003Cbr\u003EСредства для общей анестезии, периферические миорелаксанты, психотропные препараты, клонидин - усиливают эффект толперизона.\u003Cbr\u003EТолперизон усиливает действие нифлумовой кислоты, поэтому при одновременном применении следует рассматривать уменьшение дозы нифлумовой кислоты или других нестероидных противовоспалительных препаратов (НПВП).\u003Cbr\u003EСледует информировать лечащего врача обо всех принимаемых вами лекарственных препаратах."},{"name":"Регистрационный номер","value":"ЛП-007814"},{"name":"Дата государственной регистрации","value":"24.01.2022"},{"name":"Владелец регистрационного удостоверения","value":"Органика","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-travm-boli-v-myshtsakh-i-sustavakh","categoryId":"15756903","navnodeId":"25542230","glfilters":["34324371:35649313","7893318:16002709"]}}},{"name":"Изготовитель","value":"Органика"},{"name":"Фасовщик","value":"Органика"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Толперизон","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-travm-boli-v-myshtsakh-i-sustavakh","categoryId":"15756903","navnodeId":"25542230","glfilters":["17796364:22629310"]}}},{"name":"Срок годности","value":"1 г."}]}},"fullSpecsGrouped":{"15117097414667581607":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"опорно-двигательная система"},{"name":"Назначение","value":"мышечные боли и спазмы, спастичность скелетных мышц"},{"name":"Показания к применению","value":"Симптоматическое лечение спастичности у взрослых, обусловленной инсультом.\u003Cbr\u003EМиофасциальный болевой синдром средней и тяжелой степени тяжести (в т.ч. мышечный спазм при дорсопатиях)."},{"name":"Противопоказания","value":"Гиперчувствительность к толперизону и/или к другим вспомогательным компонентам препарата;\u003Cbr\u003E- миастения gravis;\u003Cbr\u003E- детский возраст до 18 лет;\u003Cbr\u003E- период грудного вскармливания;\u003Cbr\u003E- непереносимость лактозы, дефицит лактазы и/или глюкозо-галактозная мальабсорбция."},{"name":"Состав","value":"1 таблетка содержит\u003Cbr\u003Eдействующее вещество: толперизона гидрохлорид - 50,00 мг или 150,00 мг;\u003Cbr\u003Eвспомогательные вещества: лактозы моногидрат - 48,50 мг или 145,50 мг, крахмал кукурузный - 28,96 мг или 86,88 мг, целлюлоза микрокристаллическая тип 101 - 14,00 мг или 42,00 мг, лимонной кислоты моногидрат - 0,73 мг или 2,19 мг, тальк - 4,50 мг или 13,50 мг, стеариновая кислота -1,31 мг или 3,93 мг, кремния диоксид коллоидный (аэросил) - 0,80 мг или 2,40 мг, гипромеллоза (гидроксипропилметилцеллюлоза) 2910 тип 606 - 1,20 мг или 3,60 мг;\u003Cbr\u003Eсостав оболочки: опадрай II белый (серия 30F28359) - 5,00 мг или 10,00 мг или другая пленкообразующая система с указанным составом: (гипромеллоза (гидроксипропилметилцеллюлоза) 2910 - 2,00 мг или 4,00 мг, титана диоксид - 1,25 мг или 2,50 мг, полиэтиленгликоль (макрогол) - 0,80 мг или 1,60 мг, лактозы моногидрат - 0,65 мг или 1,30 мг, триацетин - 0,30 мг или 0,60 мг)."},{"name":"Действующее вещество","value":"Толперизон"},{"name":"Способ применения и дозы","value":"Внутрь, после еды, не разжевывая, не разламывая таблетку, запивая небольшим количеством воды. Биодоступность толперизона снижается при приеме натощак.\u003Cbr\u003EПо 50 мг 3 раза в день, постепенно повышая дозу до 150 мг 3 раза в день.\u003Cbr\u003EПациенты с почечной недостаточностью\u003Cbr\u003EОпыт применения толперизона у пациентов с почечной недостаточностью ограничен, у данной категории пациентов чаще возникали нежелательные реакции, поэтому у пациентов с нарушениями функции почек средней степени необходимо проводить подбор дозы толперизона с тщательным наблюдением за состоянием здоровья пациента и контролем функции почек. При тяжелом поражении почек назначение толперизона не рекомендуется.\u003Cbr\u003EПациенты с печеночной недостаточностью\u003Cbr\u003EОпыт применения толперизона у пациентов с печеночной недостаточностью ограничен. У данной категории пациентов чаще возникали нежелательные реакции, поэтому у пациентов с нарушениями функции печени средней степени необходимо проводить подбор дозы толперизона с тщательным наблюдением за состоянием здоровья пациента и контролем функции печени. При тяжелых поражениях печени назначение толперизона не рекомендуется."},{"name":"Побочные действия","value":"Профиль безопасности толперизона подтверждается данными применения более чем у 12000 пациентов. Согласно этим данным, наиболее часто описаны нарушения со стороны кожи и подкожных тканей, общие, неврологические и желудочно-кишечные расстройства.\u003Cbr\u003EВ пострегистрационный период использования толперизона количество полученных сообщений о развитии реакций гиперчувствительности, связанных с применением толперизона, составляло около 50 - 60 % всех полученных сообщений. В большинстве случаев это были несерьезные побочные реакции. Об угрожающих жизни аллергических реакциях сообщалось очень редко.\u003Cbr\u003EЧастота побочных явлений классифицирована согласно рекомендациям Всемирной организации здравоохранения: очень часто (≥ 1/10), часто (≥ 1/100, \u003C 1/10), нечасто (≥ 1/1000, \u003C 1/100), редко (≥ 1/10000, \u003C 1/1000), очень редко (\u003C 1/10000), частота неизвестна (частоту возникновения нежелательных реакций невозможно оценить на основании имеющихся данных).\u003Cbr\u003EНарушения со стороны крови и лимфатической системы: очень редко - анемия, лимфаденопатия.\u003Cbr\u003EНарушения со стороны иммунной системы: редко - реакции гиперчувствительности*, анафилактические реакции; очень редко - анафилактический шок.\u003Cbr\u003EНарушения метаболизма и питания: нечасто - анорексия; очень редко - полидипсия.\u003Cbr\u003EПсихические нарушения: нечасто - нарушение сна, бессонница; редко - слабость, депрессия; очень редко - спутанность сознания.\u003Cbr\u003EНарушения со стороны нервной системы: нечасто головная боль, головокружение, сонливость; редко - синдром дефицита внимания, тремор, эпилепсия, парестезия, судороги, недомогание, летаргия.\u003Cbr\u003EНарушения со стороны органа зрения: редко - снижение остроты зрения.\u003Cbr\u003EНарушения со стороны органа слуха и лабиринта: редко - шум в ушах, вертиго.\u003Cbr\u003EНарушения со стороны сердца: редко - стенокардия, тахикардия, ощущение сердцебиения; очень редко - брадикардия.\u003Cbr\u003EНарушения со стороны сосудов: нечасто - артериальная гипотензия; редко - «приливы» крови к лицу.\u003Cbr\u003EНарушения со стороны дыхательной системы, органов грудной клетки и средостения: редко - одышка, носовое кровотечение, тахипноэ.\u003Cbr\u003EЖелудочно-кишечные нарушения: нечасто - дискомфорт в животе, диспепсия, диарея, сухость во рту, тошнота; редко - боль в эпигастрии, запор, метеоризм, рвота.\u003Cbr\u003EНарушения со стороны печени и желчевыводящих путей: редко - печеночная недостаточность средней степени.\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей: редко - аллергический дерматит, гипергидроз, кожный зуд, кожная сыпь, крапивница.\u003Cbr\u003EНарушения со стороны мышечной, скелетной и соединительной ткани: нечасто - боль в мышцах, мышечная слабость, боль в конечностях; редко - дискомфорт в конечностях; очень редко - остеопения.\u003Cbr\u003EНарушения со стороны почек и мочевыводящих путей: редко - энурез, протеинурия.\u003Cbr\u003EОбщие нарушения и реакции в месте введения: нечасто - астения, чувство усталости, недомогания; редко - ощущение опьянения, ощущение тепла, раздражительность, жажда; очень редко - дискомфорт в грудной клетке.\u003Cbr\u003EЛабораторные и инструментальные данные: редко - гипербилирубинемия, нарушение функции печени, тромбоцитопения, лейкоцитоз; очень редко - гиперкреатининемия.\u003Cbr\u003E* В рамках пострегистрационного мониторинга сообщалось об ангионевротическом отеке, включая отек лица и губ (частота неизвестна).\u003Cbr\u003EВажно сообщать о подозреваемых нежелательных реакциях с целью обеспечения непрерывного мониторинга отношения пользы и риска лекарственного препарата. Если у Вас возникли какие - либо нежелательные реакции, обратитесь к лечащему врачу, работнику аптеки или производителю. Медицинским работникам рекомендуется сообщать о любых подозреваемых нежелательных реакциях лекарственного препарата через национальные системы сообщения о нежелательных реакциях."},{"name":"Фармакологическое действие","value":"Миорелаксант центрального действия. Механизм действия полностью не выяснен. Толперизон обладает высокой аффинностью к нервной ткани, достигая наибольших концентраций в стволе головного мозга, спинном мозге и периферической нервной системе. Основной эффект толперизона опосредован торможением спинальных рефлекторных дуг. Вероятно, этот эффект совместно с устранением облегчения проведения возбуждения по нисходящим путям обеспечивает терапевтическое воздействие толперизона. Химическая структура толперизона схожа со структурой лидокаина. Подобно лидокаину, толперизон обладает мембраностабилизирующим действием и снижает электрическую возбудимость двигательных нейронов и первичных афферентных волокон. Толперизон дозозависимо тормозит активность потенциалзависимых натриевых каналов. Соответственно, снижается амплитуда и частота потенциала действия. Также был доказан угнетающий эффект на потенциалзависимые кальциевые каналы. Предполагается, что в дополнение к его мембраностабилизирующему действию толперизон может также тормозить выброс медиатора. Толперизон обладает некоторыми слабыми свойствами α-адренергических антагонистов и антимускариновым действием."},{"name":"Фармакологическая группа","value":"миорелаксант центрального действия"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"При температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Данные о передозировке толперизона немногочисленные.\u003Cbr\u003EВ доклинических исследованиях острой токсичности высокие дозы толперизона вызывали атаксию, тонико-клонические судороги, одышку и дыхательный паралич.\u003Cbr\u003EТолперизон не имеет специфического антидота. При передозировке рекомендуется симптоматическое и поддерживающее лечение."},{"name":"Применение при беременности и кормлении грудью","value":"Беременность\u003Cbr\u003EВ экспериментальных исследованиях на животных не выявлено тератогенного действия толперизона. По причине отсутствия значимых клинических данных толперизон не следует применять при беременности (особенно в 1 триместре), за исключением случаев, когда ожидаемая польза определенно оправдывает потенциальный риск для плода.\u003Cbr\u003EПериод грудного вскармливания\u003Cbr\u003EПоскольку данные о выделении толперизона с грудным молоком отсутствуют, то его применение в период кормления грудью противопоказано."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"При приеме толперизона возможно развитие побочных эффектов (головокружение, сонливость), поэтому следует соблюдать осторожность при управлении транспортными средствами и выполнении работ, требующих повышенной концентрации внимания."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EПрепарат следует применять с осторожностью у женщин, пациентов с гиперчувствительностью к лидокаину и/или другим препаратам или с аллергией в анамнезе (см. раздел «Особые указания»), у пациентов с почечной и печеночной недостаточностью (см. раздел «Способ применения и дозы»).\u003Cbr\u003EЕсли у Вас имеется какое - либо из вышеперечисленных состояний/заболеваний перед приемом препарата обязательно проконсультируйтесь с врачом.\u003Cbr\u003EНаиболее частыми нежелательными реакциями являются реакции гиперчувствительности. Аллергические реакции проявляются от легких кожных до тяжелых системных, включая анафилактический шок. Симптомы аллергических реакций: покраснение, сыпь, крапивница, зуд, ангионевротический отек (отек Квинке), тахикардия, артериальная гипотензия, одышка.\u003Cbr\u003EПациенты женского пола с реакциями гиперчувствительности к другим препаратам или аллергическими реакциями в анамнезе подвержены более высокому риску.\u003Cbr\u003EВ случае известной гиперчувствительности к лидокаину при применении толперизона следует соблюдать повышенную осторожность из-за возможных перекрестных реакций. Пациентам следует быть внимательными в отношении любых симптомов гиперчувствительности. Если возникли симптомы, то следует немедленно прекратить прием толперизона и немедленно обратиться к врачу.\u003Cbr\u003EНе следует повторно назначать толперизон после эпизода гиперчувствительности к лекарственному препарату, его содержащему."},{"name":"Взаимодействие","value":"Исследования фармакокинетического лекарственного взаимодействия с маркерным субстратом изофермента CYP2D6 декстрометорфаном показали, что одновременное применение толперизона может повысить содержание в крови лекарственных средств, которые метаболизируются преимущественно изоферментом CYP2D6 (тиоридазон, толтеродин, венлафаксин, атомоксетин, дезипрамин, декстрометорфан, метопролол, небиволол, перфеназин).\u003Cbr\u003EВ лабораторных экспериментах на микросомах печени человека и гепатоцитах человека значительного ингибирования или индукции других изоферментов CYP (CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP1A2, CYP3A4) не обнаружено.\u003Cbr\u003EВ связи с разнообразием метаболических путей толперизона повышение экспозиции толперизона при одновременном применении субстратов изофермента CYP2D6 и (или) других препаратов не ожидается.\u003Cbr\u003EБиодоступность толперизона снижается при приеме натощак.\u003Cbr\u003EНесмотря на то, что толперизон является препаратом центрального действия, седативный эффект его очень низкий. При одновременном применении с другими миорелаксантами центрального действия дозу толперизона следует уменьшать.\u003Cbr\u003EСредства для общей анестезии, периферические миорелаксанты, психотропные препараты, клонидин - усиливают эффект толперизона.\u003Cbr\u003EТолперизон усиливает действие нифлумовой кислоты, поэтому при одновременном применении следует рассматривать уменьшение дозы нифлумовой кислоты или других нестероидных противовоспалительных препаратов (НПВП).\u003Cbr\u003EСледует информировать лечащего врача обо всех принимаемых вами лекарственных препаратах."},{"name":"Регистрационный номер","value":"ЛП-007814"},{"name":"Дата государственной регистрации","value":"24.01.2022"},{"name":"Владелец регистрационного удостоверения","value":"Органика"},{"name":"Изготовитель","value":"Органика"},{"name":"Фасовщик","value":"Органика"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Толперизон"},{"name":"Срок годности","value":"1 г."}]}],"transitionId":"tr_8503232683217611694"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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162 ₽

Скидка: 24%
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Вместо:212 ₽
  • 11-13 июня, самовывоз • 0 ₽
POLZAru
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  • Толперизон таб. п/о плен., 150 мг, 30 шт.
    –11 %
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    Толперизон таб. п/о плен., 150 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 4 оценки
    Цена 329 ₽ вместо 369
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  • Толперизон-СЗ таб. п/о плен., 150 мг, 30 шт.
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    Толперизон-СЗ таб. п/о плен., 150 мг, 30 шт.

    Рейтинг товара: 4.7 из 5
    на основе 6 оценок
    Цена 336 ₽
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  • Толперизон-OBL таб. п/о плен., 50 мг, 30 шт.
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    Толперизон-OBL таб. п/о плен., 50 мг, 30 шт.

    Рейтинг товара: 4.6 из 5
    на основе 26 оценок
    Цена 396 ₽
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  • Толперизон Медисорб таб. п/о плен., 150 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-26of3qiby4d/toggleWishlist":{"skuId":"707573236","productId":1422663635,"offerId":"_hJpEHHKrho1rJuoJMqS8w","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ6Kzi26CqquQOEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYI07+wpgUQ9Ouy0QIYm5eQByDn3MEH","sign":"IsGXm5lvYsspb3puxz389rAb9BoGx13JF3qQPZn32Ew="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-26of3qiby4d/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Толперизон Медисорб таб. п/о плен., 150 мг, 30 шт.

    Рейтинг товара: 4.9 из 5
    на основе 24 оценки
    Цена 203 ₽
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  • Кетопрофен органика таб. п/о плен., 100 мг, 20 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-1ym7tyk55ay/toggleWishlist":{"skuId":"101734566736","productId":265134530,"offerId":"GepXWcKTE-FcPEO2t06IWg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ6Kzi26CqquQOEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIwsO2fhDQlun++gIYld3QByDn3MEH","sign":"TG6UKAoa5oBg7PI1VV1XGSK5bgdkhmfEfxyRE74rvY4="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-1ym7tyk55ay/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Кетопрофен органика таб. п/о плен., 100 мг, 20 шт.

    Рейтинг товара: 4.2 из 5
    на основе 11 оценок
    Цена 143 ₽
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  • Кетопрофен таб. п/о плен., 100 мг, 20 шт.
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    Кетопрофен таб. п/о плен., 100 мг, 20 шт.

    Рейтинг товара: 4.9 из 5
    на основе 7 оценок
    Цена 128 ₽
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  • Мидокалм таб. п/о плен., 150 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-osxx3i3n0p/toggleWishlist":{"skuId":"186487546","productId":1422663416,"offerId":"vyOMkKioKqYnhmJmg4rpHw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ6Kzi26CqquQOEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI+L2wpgUQ+qX2WBj+1bYIIOfcwQc=","sign":"UKqgKoZnAywyUNXuqO0NrqlZ8Cd59Vygu+vwaBxMu7I="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-osxx3i3n0p/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Мидокалм таб. п/о плен., 150 мг, 30 шт.

    Рейтинг товара: 4.5 из 5
    на основе 94 оценки
    Цена 538 ₽
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-osxx3i3n0p/addToCartButton":{"offerId":"vyOMkKioKqYnhmJmg4rpHw","skuId":"186487546","pendingCartItem":{"productId":1422663416,"offerId":"vyOMkKioKqYnhmJmg4rpHw","showPlaceId":"OTNDnItfwRMjN9MRHuEMMmXGbpH6N69uur34C2CujA6sl_xamHLtr-J1iCi7zrMarH01qxKj2A_U8QWll_jq0DpydvmjD-2j8FrpKofCwBYYj9oZMg1rAxwaPQl0D1yS7mbj1vTcKgQzidiPODF1cyAx7VhmEtN3BooD92Z1cmjMj6xIS2v-lMwVsCxGDKXRzkcV981dKRFoGiOBr4CTXg,,","feeShow":"OTNDnItfwRMjN9MRHuEMMmXGbpH6N69uur34C2CujA6sl_xamHLtr-J1iCi7zrMarH01qxKj2A_U8QWll_jq0DpydvmjD-2j8FrpKofCwBYYj9oZMg1rAxwaPQl0D1yS7mbj1vTcKgQzidiPODF1cyAx7VhmEtN3BooD92Z1cmjMj6xIS2v-lMwVsCxGDKXRzkcV981dKRFoGiOBr4CTXg,,","skuId":"186487546","shopId":77075781,"price":{"applicablePriceDiscounts":[],"value":"538","currency":"RUR"},"hid":"15756903","name":"Мидокалм таб. п/о плен., 150 мг, 30 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  • Аллопуринол таб., 100 мг, 50 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-hb17jwoo1pn/toggleWishlist":{"skuId":"226689490","productId":1422663455,"offerId":"kxNA7gSJfjf5VV1TqOZmRg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ6Kzi26CqquQOEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIn76wpgUQ0oOMbBiV3dAHIOfcwQc=","sign":"2dcDMYOAcbYJgrfZayDB/Zb78f1EePAzaK23qI2VNSg="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-hb17jwoo1pn/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Аллопуринол таб., 100 мг, 50 шт.

    Рейтинг товара: 5 из 5
    на основе 27 оценок
    Цена 140 ₽
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Инструкция

Показания к применению

Симптоматическое лечение спастичности у взрослых, обусловленной инсультом.
Миофасциальный болевой синдром средней и тяжелой степени тяжести (в т.ч. мышечный спазм при дорсопатиях).

Противопоказания

Гиперчувствительность к толперизону и/или к другим вспомогательным компонентам препарата;
- миастения gravis;
- детский возраст до 18 лет;
- период грудного вскармливания;
- непереносимость лактозы, дефицит лактазы и/или глюкозо-галактозная мальабсорбция.

Способ применения и дозы

Внутрь, после еды, не разжевывая, не разламывая таблетку, запивая небольшим количеством воды. Биодоступность толперизона снижается при приеме натощак.
По 50 мг 3 раза в день, постепенно повышая дозу до 150 мг 3 раза в день.
Пациенты с почечной недостаточностью
Опыт применения толперизона у пациентов с почечной недостаточностью ограничен, у данной категории пациентов чаще возникали нежелательные реакции, поэтому у пациентов с нарушениями функции почек средней степени необходимо проводить подбор дозы толперизона с тщательным наблюдением за состоянием здоровья пациента и контролем функции почек. При тяжелом поражении почек назначение толперизона не рекомендуется.
Пациенты с печеночной недостаточностью
Опыт применения толперизона у пациентов с печеночной недостаточностью ограничен. У данной категории пациентов чаще возникали нежелательные реакции, поэтому у пациентов с нарушениями функции печени средней степени необходимо проводить подбор дозы толперизона с тщательным наблюдением за состоянием здоровья пациента и контролем функции печени. При тяжелых поражениях печени назначение толперизона не рекомендуется.
Полная инструкция
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Толперизон органика таб. п/о плен.
Толперизон органика таб. п/о плен., 50 мг, 30 шт.
4.8
(12)
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Задать вопрос
Инструкция

162 ₽

Скидка: 24%
–24 %
Вместо:212 ₽
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4.8
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У продавца:12 оценок·6 отзывов
Больше нет оценок и отзывов на Маркете
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Год назад • Марина Ч. • Куплен на Маркете
Достоинства: всё хорошо..... очень хорошо обезбаливает при шейном остеохондрозе и ДОА....
Комментарий: табл. употр. уже второй раз..... от невропатолога..... по 1т . 2 раза в день.....
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6 месяцев назад • ВИТАЛИЙ ЯКОВЛЕВ • Куплен на Маркете
Достоинства: хорошее лекарство
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9 месяцев назад • Дмитрий Лабузов • Куплен на Маркете
Достоинства: Ни чем не хуже раскрученных брендов!
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