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Описание

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Леветирацетам Канон таб. п/о плен., 1000 мг, 30 шт.

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4.9
(25)
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Дозировка: 1000 мг

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Коротко о товаре

Артикул Маркета
3303084882
Тип препарата
Назначение
Действующее вещество
Возраст
от 6 лет
Инструкция
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чувствительность к леветирацетаму или другим производным пирролидона, а также к любым компонентам препарата."},{"name":"Состав","value":"Дозировка 250 мг\u003Cbr\u003E1 таблетка, покрытая пленочной оболочкой, содержит:\u003Cbr\u003Eактивное вещество: леветирацетам 250 мг;\u003Cbr\u003Eвспомогательные вещества: кремния диоксид коллоидный 3 мг, кроскармеллоза натрия 10 мг, кальция стеарат 3 мг, маннитол 20,2 мг, повидон 6,3 мг, целлюлоза микрокристаллическая 17,5 мг;\u003Cbr\u003Eсостав пленочной оболочки: Опадрай II синий 10 мг, в том числе: поливиниловый спирт 4 мг, макрогол (полиэтиленгликоль) 2,02 мг, тальк 1,48 мг, титана диоксид 2,05 мг, алюминиевый лак на основе красителя индигокармин 0,43 мг, алюминиевый лак на основе красителя красный очаровательный 0,02 мг.\u003Cbr\u003EДозировка 500 мг\u003Cbr\u003E1 таблетка, покрытая пленочной оболочкой, содержит:\u003Cbr\u003Eактивное вещество: леветирацетам 500 мг;\u003Cbr\u003Eвспомогательные вещества: кремния диоксид коллоидный 6 мг, кроскармеллоза натрия 20 мг, кальция стеарат 6 мг, маннитол 40,4 мг, повидон 12,6 мг, целлюлоза микрокристаллическая 35 мг;\u003Cbr\u003Eсостав пленочной оболочки: Опадрай II синий 20 мг, в том числе: поливиниловый спирт 8 мг, макрогол (полиэтиленгликоль) 4,04 мг, тальк 2,96 мг, титана диоксид 4,1 мг, алюминиевый лак на основе красителя индигокармин 0,86 мг, алюминиевый лак на основе красителя красный очаровательный 0,04 мг.\u003Cbr\u003EДозировка 1000 мг\u003Cbr\u003E1 таблетка, покрытая пленочной оболочкой, содержит:\u003Cbr\u003Eактивное вещество: леветирацетам 1000 мг;\u003Cbr\u003Eвспомогательные вещества: кремния диоксид коллоидный 12 мг, кроскармеллоза натрия 40 мг, кальция стеарат 12 мг, маннитол 80,8 мг, повидон 25,2 мг, целлюлоза микрокристаллическая 70 мг;\u003Cbr\u003Eсостав пленочной оболочки: Опадрай II синий 40 мг, в том числе: поливиниловый спирт 16 мг, макрогол (полиэтиленгликоль) 8,08 мг, тальк 5,92 мг, титана диоксид 8,2 мг, алюминиевый лак на основе красителя 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Суточную дозу препарата делят на два приема в одинаковой дозе.\u003Cbr\u003EМонотерапия\u003Cbr\u003EВзрослым и подросткам старше 16 лет лечение следует начинать с суточной дозы 500 мг, разделенной на 2 приема (по 250 мг 2 раза в сутки). Через 2 недели доза может быть увеличена до начальной терапевтической - 1000 мг (по 500 мг 2 раза в сутки). Максимальная суточная доза составляет 3000 мг (по 1500 мг 2 раза в сутки).\u003Cbr\u003EВ составе комплексной терапии\u003Cbr\u003EДетям старше 6 лет лечение следует начинать с суточной дозы 20 мг/кг массы тела, разделенной на 2 приема (по 10 мг/кг массы тела 2 раза в сутки). Изменение дозы на 20 мг/кг массы тела может осуществляться каждые 2 недели до достижения рекомендуемой суточной дозы - 60 мг/кг массы тела (по 30 мг/кг массы тела 2 раза в сутки). При непереносимости рекомендуемой суточной дозы возможно ее снижение. Следует применять минимальную эффективную дозы. Врач должен назначить препарат в наиболее подходящей дозировке в зависимости от массы тела пациента и необходимой терапевтической дозы.\u003Cbr\u003EДетям с массой тела более 50 кг дозирование осуществляется по схеме, приведенной для взрослых.\u003Cbr\u003EВзрослым и подросткам старше 16 лет с массой тела более 50 кг лечение следует начинать с суточной дозы 1000 мг, разделенной на 2 приема (по 500 мг 2 раза в сутки). В зависимости от клинической реакции и переносимости препарата суточная доза может быть увеличена до максимальной - 3000 мг (по 1500 мг 2 раза в сутки). Изменение дозы на 500 мг 2 раза в сутки может осуществляться каждые 2-4 недели.\u003Cbr\u003EПоскольку леветирацетам выводится из организма почками, при назначении препарата пациентам с почечной недостаточностью и пациентам пожилого возраста дозу следует корректировать в зависимости от величины клиренса креатинина (КК)."},{"name":"Побочные действия","value":"Классификация ВОЗ частоты развития побочных эффектов:\u003Cbr\u003Eочень часто - ≥1/10 назначений (\u003E10%)\u003Cbr\u003Eчасто - от ≥1/100 до \u003C 1/10 назначений (\u003E1% и \u003C10%)\u003Cbr\u003Eнечасто - от ≥1/1000 до \u003C1/100 назначений (\u003E0,1% и \u003C1%)\u003Cbr\u003Eредко - от ≥1/10000 до \u003C1/1000 назначений (\u003E0,01% и \u003C0,1%)\u003Cbr\u003Eочень редко - \u003C1/10000 назначений (\u003C0,01%)\u003Cbr\u003EСо стороны нервной системы и психики\u003Cbr\u003EОчень часто: сонливость, головная боль, астенический синдром.\u003Cbr\u003EЧасто: судороги, головокружение, головная боль, тремор, нарушение равновесия, возбуждение, депрессия, переменчивость настроения, враждебность/агрессивность, бессонница, нервозность, раздражительность, расстройства личности, нарушение мышления, тревога, вертиго.\u003Cbr\u003EНечасто: атаксия, амнезия, снижение концентрации внимания, ухудшение памяти, попытки суицида, суицидальные намерения, психотические расстройства, поведенческие расстройства, галлюцинации, спутанность сознания, эмоциональная лабильность.\u003Cbr\u003EРедко: хореоатетоз, дискинезия, гиперкинезия, суицид, расстройство личности, нарушение мышления.\u003Cbr\u003EСо стороны органов зрения\u003Cbr\u003EНечасто: диплопия, нарушение аккомодации.\u003Cbr\u003EСо стороны дыхательной системы\u003Cbr\u003EЧасто: усиление кашля.\u003Cbr\u003EСо стороны пищеварительной системы\u003Cbr\u003EЧасто: абдоминальная боль, диарея, диспепсия, тошнота, рвота, анорексия, повышение массы тела.\u003Cbr\u003EНечасто: панкреатит, изменения функциональных печеночных проб.\u003Cbr\u003EРедко: печеночная недостаточность, гепатит, снижение массы тела.\u003Cbr\u003EСо стороны кожных покровов\u003Cbr\u003EЧасто: кожная сыпь.\u003Cbr\u003EНечасто: экзема, зуд, алопеция (в ряде случаев восстановление волосяного покрова наблюдалось после отмены препарата).\u003Cbr\u003EРедко: токсический эпидермальный некролиз, Синдром Стивенса-Джонсона, многоформная эритема.\u003Cbr\u003EИзменения лабораторных показателей\u003Cbr\u003EНечасто: тромбоцитопения, лейкопения.\u003Cbr\u003EРедко: нейтропения, панцитопения (в некоторых случаях с угнетением функции костного мозга).\u003Cbr\u003EПрочие\u003Cbr\u003EИнфекции, назофарингит, миалгия, мышечная слабость, склонность к травмам.\u003Cbr\u003EУ детей: рвота, возбуждение, переменчивость настроения, эмоциональная лабильность, агрессивность, поведенческие расстройства, летаргия."},{"name":"Фармакологическое действие","value":"Леветирацетам является производным пирролидона (S-энантиомер α-этил-2-оксо-1-пирролидин-ацетамида), по химической структуре отличается от известных противоэпилептических лекарственных средств. Механизм действия леветирацетама до конца не изучен, но очевидно, что он отличается от механизма действия известных противоэпилептических препаратов. Эксперименты in vitro и in vivo показали, что леветирацетам не влияет на основные характеристики клеток и нормальную трансмиссию. В исследованиях in vitro показано, что он влияет на внутринейрональную концентрацию ионов Са, частично тормозя ток ионов кальция через каналы N-типа и уменьшая высвобождение кальция из внутринейрональных депо. Кроме того он частично восстанавливает токи через ГАМК и глицин-зависимые каналы. Один из предполагаемых механизмов основан на доказанном связывании с гликопротеином синаптических везикул SV2A, содержащемся в сером веществе головного и спинного мозга. Считается, что таким образом реализуется противосудорожный эффект, который выражен в противодействии гиперсинхронизации нейронной активности. Также леветирацетам воздействует на рецепторы ГАМК и глициновые рецепторы, модулируя данные рецепторы через различные эндогенные агенты. Препарат не изменяет нормальную нейротрансмиссию, однако подавляет эпилептиформные нейрональные вспышки, индуцированные ГАМК-агонистом бикукулином, и возбуждение глутаматных рецепторов. Активность препарата подтверждена в отношении как фокальных, так и генерализованных эпилептических припадков (эпилептиформные проявления/фотопароксизмальная реакция)."},{"name":"Фармакологическая группа","value":"противоэпилептические средства"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 6 лет"},{"name":"Условия хранения","value":"При температуре не выше 25 °С во вторичной упаковке (пачке картонной).\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы: сонливость, ажитация, агрессивность, угнетение сознания, угнетение дыхания, кома.\u003Cbr\u003EЛечение: в остром периоде - искусственный вызов рвоты и промывание желудка с последующим назначением активированного угля. Специфического антидота для леветирацетама нет. При необходимости проводится симптоматическое лечение в условиях стационара с использованием гемодиализа (эффективность диализа для леветирацетама составляет 60%, для его первичного метаболита - 74%)."},{"name":"Применение при беременности и кормлении грудью","value":"Адекватных и строго контролируемых клинических исследований по безопасности применения леветирацетама у беременных не проводилось, поэтому препарат не следует назначать во время беременности, за исключением случаев крайней необходимости. Необходимо соблюдать контрацепцию женщинам с сохраненным детородным потенциалом.\u003Cbr\u003EФизиологические изменения в организме женщины во время беременности могут влиять на концентрацию в плазме леветирацетама, так же, как и других противоэпилептических препаратов. Во время беременности отмечено снижение концентрации леветирацетама в плазме. Это снижение более выражено в третьем триместре (до 60% от базовой концентрации в период, предшествующий беременности).\u003Cbr\u003EЛечение леветирацетамом беременных следует проводить под особым контролем. Перерывы в проведении противоэпилептической терапии могут привести к ухудшению течения заболевания, что может нанести вред здоровью как матери, так и плода. Леветирацетам выделяется с грудным молоком, поэтому грудное вскармливание при лечении препаратом противопоказано."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Влияние препарата леветирацетама на способность к вождению автотранспорта и управлению механизмами специально не изучалось. Тем не менее, в силу различной индивидуальной чувствительности к препарату со стороны центральной нервной системы в период лечения, необходимо воздерживаться от вождения автотранспорта и занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EПациенты пожилого возраста (старше 65 лет);\u003Cbr\u003Eзаболевания печени в стадии декомпенсации;\u003Cbr\u003Eпочечная недостаточность (клиренс креатинина менее 50 мл/мин).\u003Cbr\u003EОтмена терапии\u003Cbr\u003EОтмену препарата рекомендуется проводить постепенно. Например, у взрослых и подростков с массой тела более 50 кг снижение дозы следует осуществлять с шагом 500 мг 2 раза в сутки не чаще, чем каждые 2-4 недели; у детей снижение дозы следует осуществлять с шагом не более 10 мг/кг 2 раза в сутки не чаще, чем каждые две недели.\u003Cbr\u003EСопутствующие противоэпилептические препараты (в период перевода пациентов на терапию леветирацетамом) желательно отменять постепенно.\u003Cbr\u003EПочечная недостаточность\u003Cbr\u003EПрименение леветирацетама у пациентов с почечной недостаточностью может потребовать коррекции дозы. У пациентов с тяжелой печеночной недостаточностью рекомендуется оценивать функцию почек до начала подбора дозы (см. раздел «Способ применения и дозы»).\u003Cbr\u003EСуицид\u003Cbr\u003EУ пациентов, принимавших противосудорожные средства (включая леветирацетам), отмечались суицид, попытки суицида, суицидальные мысли и поведение. В связи с вышеизложенным необходимо осуществлять наблюдение за пациентами с симптомами депрессии или суицидальных мыслей и поведения и назначать им соответствующую терапию. Пациентов (и лицам, ухаживающим за ними) следует проинформировать о необходимости обращения за медицинской помощью при возникновении у них симптомов депрессии и (или) суицидальных мыслей и поведения.\u003Cbr\u003EДети\u003Cbr\u003EТаблетки не предназначены для применения у детей в возрасте младше 6 лет. Для детей младше 6 лет рекомендуемой лекарственной формой является раствор для приема внутрь.\u003Cbr\u003EПо имеющимся данным леветирацетам не влияет на рост и половое созревание. Однако долгосрочное влияние на обучение, интеллект, рост, эндокринную функцию, половое созревание и фертильность детей не известно."},{"name":"Взаимодействие","value":"Препарат не взаимодействует с противоэпилептическими препаратами (фенитоин, карбамазепин, вальпроевая кислота, фенобарбитал, ламотриджин, габапентин и прими дон).\u003Cbr\u003EЛеветирацетам в суточной дозе 1000 мг не изменяет фармакокинетику пероральных противозачаточных средств (этинилэстрадиола и левоноргестрела).\u003Cbr\u003EЛеветирацетам в суточной дозе 2000 мг не изменяет фармакокинетику дигоксина и варфарина.\u003Cbr\u003EДигоксин, пероральные противозачаточные средства и варфарин не влияют на фармакокинетику леветирацетама.\u003Cbr\u003EПри совместном приеме с топираматом выше вероятность развития анорексии.\u003Cbr\u003EПолнота всасывания леветирацетама не изменяется под воздействием пищи, при этом скорость всасывания несколько снижается.\u003Cbr\u003EДанных о взаимодействии леветирацетама с алкоголем нет.\u003Cbr\u003EКлиренс леветирацетама был выше на 20% у детей, принимающих противосудорожные средства - индукторы микросомального окисления в печени, по сравнении с детьми, их не принимающими. Снижение почечной секреции первичного метаболита наблюдалось при приеме пробенецида в дозе 500 мг 4 раза в день."},{"name":"Регистрационный номер","value":"ЛП-002135"},{"name":"Дата государственной регистрации","value":"06.09.2021"},{"name":"Владелец регистрационного удостоверения","value":"Канонфарма продакшн","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["34324371:35649313","7893318:16146766"]}}},{"name":"Изготовитель","value":"Канонфарма продакшн"},{"name":"Фасовщик","value":"Канонфарма продакшн"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Леветирацетам Канон","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["17796364:18028691"]}}},{"name":"Срок годности","value":"36 мес."}]}},"fullSpecsGrouped":{"4764001993709572246":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"нервная система"},{"name":"Назначение","value":"миоклонические судороги, парциальные судороги, тонико-клонические припадки, эпилепсия"},{"name":"Показания к применению","value":"В качестве монотерапии (препарат первого выбора) при лечении\u003Cbr\u003Eпарциальных припадков с вторичной генерализацией или без таковой у взрослых и подростков старше 16 лет с вновь диагностированной эпилепсией.\u003Cbr\u003EВ составе комплексной терапии при лечении\u003Cbr\u003Eпарциальных припадков с вторичной генерализацией или без таковой у взрослых и детей старше 6 лет, страдающих эпилепсией;\u003Cbr\u003Eмиоклонических судорог у взрослых и подростков старше 12 лет, страдающих ювенильной миоклонической эпилепсией;\u003Cbr\u003Eпервично-генерализованных судорожных (тонико-клонических) припадков у взрослых и подростков старше 12 лет, страдающих идиопатической генерализованной эпилепсией."},{"name":"Противопоказания","value":"Повышенная чувствительность к леветирацетаму или другим производным пирролидона, а также к любым компонентам препарата."},{"name":"Состав","value":"Дозировка 250 мг\u003Cbr\u003E1 таблетка, покрытая пленочной оболочкой, содержит:\u003Cbr\u003Eактивное вещество: леветирацетам 250 мг;\u003Cbr\u003Eвспомогательные вещества: кремния диоксид коллоидный 3 мг, кроскармеллоза натрия 10 мг, кальция стеарат 3 мг, маннитол 20,2 мг, повидон 6,3 мг, целлюлоза микрокристаллическая 17,5 мг;\u003Cbr\u003Eсостав пленочной оболочки: Опадрай II синий 10 мг, в том числе: поливиниловый спирт 4 мг, макрогол (полиэтиленгликоль) 2,02 мг, тальк 1,48 мг, титана диоксид 2,05 мг, алюминиевый лак на основе красителя индигокармин 0,43 мг, алюминиевый лак на основе красителя красный очаровательный 0,02 мг.\u003Cbr\u003EДозировка 500 мг\u003Cbr\u003E1 таблетка, покрытая пленочной оболочкой, содержит:\u003Cbr\u003Eактивное вещество: леветирацетам 500 мг;\u003Cbr\u003Eвспомогательные вещества: кремния диоксид коллоидный 6 мг, кроскармеллоза натрия 20 мг, кальция стеарат 6 мг, маннитол 40,4 мг, повидон 12,6 мг, целлюлоза микрокристаллическая 35 мг;\u003Cbr\u003Eсостав пленочной оболочки: Опадрай II синий 20 мг, в том числе: поливиниловый спирт 8 мг, макрогол (полиэтиленгликоль) 4,04 мг, тальк 2,96 мг, титана диоксид 4,1 мг, алюминиевый лак на основе красителя индигокармин 0,86 мг, алюминиевый лак на основе красителя красный очаровательный 0,04 мг.\u003Cbr\u003EДозировка 1000 мг\u003Cbr\u003E1 таблетка, покрытая пленочной оболочкой, содержит:\u003Cbr\u003Eактивное вещество: леветирацетам 1000 мг;\u003Cbr\u003Eвспомогательные вещества: кремния диоксид коллоидный 12 мг, кроскармеллоза натрия 40 мг, кальция стеарат 12 мг, маннитол 80,8 мг, повидон 25,2 мг, целлюлоза микрокристаллическая 70 мг;\u003Cbr\u003Eсостав пленочной оболочки: Опадрай II синий 40 мг, в том числе: поливиниловый спирт 16 мг, макрогол (полиэтиленгликоль) 8,08 мг, тальк 5,92 мг, титана диоксид 8,2 мг, алюминиевый лак на основе красителя индигокармин 1,72 мг, алюминиевый лак на основе красителя красный очаровательный 0,08 мг."},{"name":"Действующее вещество","value":"Леветирацетам"},{"name":"Способ применения и дозы","value":"Внутрь, независимо от приема пищи, запивая достаточным количеством жидкости. Суточную дозу препарата делят на два приема в одинаковой дозе.\u003Cbr\u003EМонотерапия\u003Cbr\u003EВзрослым и подросткам старше 16 лет лечение следует начинать с суточной дозы 500 мг, разделенной на 2 приема (по 250 мг 2 раза в сутки). Через 2 недели доза может быть увеличена до начальной терапевтической - 1000 мг (по 500 мг 2 раза в сутки). Максимальная суточная доза составляет 3000 мг (по 1500 мг 2 раза в сутки).\u003Cbr\u003EВ составе комплексной терапии\u003Cbr\u003EДетям старше 6 лет лечение следует начинать с суточной дозы 20 мг/кг массы тела, разделенной на 2 приема (по 10 мг/кг массы тела 2 раза в сутки). Изменение дозы на 20 мг/кг массы тела может осуществляться каждые 2 недели до достижения рекомендуемой суточной дозы - 60 мг/кг массы тела (по 30 мг/кг массы тела 2 раза в сутки). При непереносимости рекомендуемой суточной дозы возможно ее снижение. Следует применять минимальную эффективную дозы. Врач должен назначить препарат в наиболее подходящей дозировке в зависимости от массы тела пациента и необходимой терапевтической дозы.\u003Cbr\u003EДетям с массой тела более 50 кг дозирование осуществляется по схеме, приведенной для взрослых.\u003Cbr\u003EВзрослым и подросткам старше 16 лет с массой тела более 50 кг лечение следует начинать с суточной дозы 1000 мг, разделенной на 2 приема (по 500 мг 2 раза в сутки). В зависимости от клинической реакции и переносимости препарата суточная доза может быть увеличена до максимальной - 3000 мг (по 1500 мг 2 раза в сутки). Изменение дозы на 500 мг 2 раза в сутки может осуществляться каждые 2-4 недели.\u003Cbr\u003EПоскольку леветирацетам выводится из организма почками, при назначении препарата пациентам с почечной недостаточностью и пациентам пожилого возраста дозу следует корректировать в зависимости от величины клиренса креатинина (КК)."},{"name":"Побочные действия","value":"Классификация ВОЗ частоты развития побочных эффектов:\u003Cbr\u003Eочень часто - ≥1/10 назначений (\u003E10%)\u003Cbr\u003Eчасто - от ≥1/100 до \u003C 1/10 назначений (\u003E1% и \u003C10%)\u003Cbr\u003Eнечасто - от ≥1/1000 до \u003C1/100 назначений (\u003E0,1% и \u003C1%)\u003Cbr\u003Eредко - от ≥1/10000 до \u003C1/1000 назначений (\u003E0,01% и \u003C0,1%)\u003Cbr\u003Eочень редко - \u003C1/10000 назначений (\u003C0,01%)\u003Cbr\u003EСо стороны нервной системы и психики\u003Cbr\u003EОчень часто: сонливость, головная боль, астенический синдром.\u003Cbr\u003EЧасто: судороги, головокружение, головная боль, тремор, нарушение равновесия, возбуждение, депрессия, переменчивость настроения, враждебность/агрессивность, бессонница, нервозность, раздражительность, расстройства личности, нарушение мышления, тревога, вертиго.\u003Cbr\u003EНечасто: атаксия, амнезия, снижение концентрации внимания, ухудшение памяти, попытки суицида, суицидальные намерения, психотические расстройства, поведенческие расстройства, галлюцинации, спутанность сознания, эмоциональная лабильность.\u003Cbr\u003EРедко: хореоатетоз, дискинезия, гиперкинезия, суицид, расстройство личности, нарушение мышления.\u003Cbr\u003EСо стороны органов зрения\u003Cbr\u003EНечасто: диплопия, нарушение аккомодации.\u003Cbr\u003EСо стороны дыхательной системы\u003Cbr\u003EЧасто: усиление кашля.\u003Cbr\u003EСо стороны пищеварительной системы\u003Cbr\u003EЧасто: абдоминальная боль, диарея, диспепсия, тошнота, рвота, анорексия, повышение массы тела.\u003Cbr\u003EНечасто: панкреатит, изменения функциональных печеночных проб.\u003Cbr\u003EРедко: печеночная недостаточность, гепатит, снижение массы тела.\u003Cbr\u003EСо стороны кожных покровов\u003Cbr\u003EЧасто: кожная сыпь.\u003Cbr\u003EНечасто: экзема, зуд, алопеция (в ряде случаев восстановление волосяного покрова наблюдалось после отмены препарата).\u003Cbr\u003EРедко: токсический эпидермальный некролиз, Синдром Стивенса-Джонсона, многоформная эритема.\u003Cbr\u003EИзменения лабораторных показателей\u003Cbr\u003EНечасто: тромбоцитопения, лейкопения.\u003Cbr\u003EРедко: нейтропения, панцитопения (в некоторых случаях с угнетением функции костного мозга).\u003Cbr\u003EПрочие\u003Cbr\u003EИнфекции, назофарингит, миалгия, мышечная слабость, склонность к травмам.\u003Cbr\u003EУ детей: рвота, возбуждение, переменчивость настроения, эмоциональная лабильность, агрессивность, поведенческие расстройства, летаргия."},{"name":"Фармакологическое действие","value":"Леветирацетам является производным пирролидона (S-энантиомер α-этил-2-оксо-1-пирролидин-ацетамида), по химической структуре отличается от известных противоэпилептических лекарственных средств. Механизм действия леветирацетама до конца не изучен, но очевидно, что он отличается от механизма действия известных противоэпилептических препаратов. Эксперименты in vitro и in vivo показали, что леветирацетам не влияет на основные характеристики клеток и нормальную трансмиссию. В исследованиях in vitro показано, что он влияет на внутринейрональную концентрацию ионов Са, частично тормозя ток ионов кальция через каналы N-типа и уменьшая высвобождение кальция из внутринейрональных депо. Кроме того он частично восстанавливает токи через ГАМК и глицин-зависимые каналы. Один из предполагаемых механизмов основан на доказанном связывании с гликопротеином синаптических везикул SV2A, содержащемся в сером веществе головного и спинного мозга. Считается, что таким образом реализуется противосудорожный эффект, который выражен в противодействии гиперсинхронизации нейронной активности. Также леветирацетам воздействует на рецепторы ГАМК и глициновые рецепторы, модулируя данные рецепторы через различные эндогенные агенты. Препарат не изменяет нормальную нейротрансмиссию, однако подавляет эпилептиформные нейрональные вспышки, индуцированные ГАМК-агонистом бикукулином, и возбуждение глутаматных рецепторов. Активность препарата подтверждена в отношении как фокальных, так и генерализованных эпилептических припадков (эпилептиформные проявления/фотопароксизмальная реакция)."},{"name":"Фармакологическая группа","value":"противоэпилептические средства"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 6 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"При температуре не выше 25 °С во вторичной упаковке (пачке картонной).\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы: сонливость, ажитация, агрессивность, угнетение сознания, угнетение дыхания, кома.\u003Cbr\u003EЛечение: в остром периоде - искусственный вызов рвоты и промывание желудка с последующим назначением активированного угля. Специфического антидота для леветирацетама нет. При необходимости проводится симптоматическое лечение в условиях стационара с использованием гемодиализа (эффективность диализа для леветирацетама составляет 60%, для его первичного метаболита - 74%)."},{"name":"Применение при беременности и кормлении грудью","value":"Адекватных и строго контролируемых клинических исследований по безопасности применения леветирацетама у беременных не проводилось, поэтому препарат не следует назначать во время беременности, за исключением случаев крайней необходимости. Необходимо соблюдать контрацепцию женщинам с сохраненным детородным потенциалом.\u003Cbr\u003EФизиологические изменения в организме женщины во время беременности могут влиять на концентрацию в плазме леветирацетама, так же, как и других противоэпилептических препаратов. Во время беременности отмечено снижение концентрации леветирацетама в плазме. Это снижение более выражено в третьем триместре (до 60% от базовой концентрации в период, предшествующий беременности).\u003Cbr\u003EЛечение леветирацетамом беременных следует проводить под особым контролем. Перерывы в проведении противоэпилептической терапии могут привести к ухудшению течения заболевания, что может нанести вред здоровью как матери, так и плода. Леветирацетам выделяется с грудным молоком, поэтому грудное вскармливание при лечении препаратом противопоказано."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Влияние препарата леветирацетама на способность к вождению автотранспорта и управлению механизмами специально не изучалось. Тем не менее, в силу различной индивидуальной чувствительности к препарату со стороны центральной нервной системы в период лечения, необходимо воздерживаться от вождения автотранспорта и занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EПациенты пожилого возраста (старше 65 лет);\u003Cbr\u003Eзаболевания печени в стадии декомпенсации;\u003Cbr\u003Eпочечная недостаточность (клиренс креатинина менее 50 мл/мин).\u003Cbr\u003EОтмена терапии\u003Cbr\u003EОтмену препарата рекомендуется проводить постепенно. Например, у взрослых и подростков с массой тела более 50 кг снижение дозы следует осуществлять с шагом 500 мг 2 раза в сутки не чаще, чем каждые 2-4 недели; у детей снижение дозы следует осуществлять с шагом не более 10 мг/кг 2 раза в сутки не чаще, чем каждые две недели.\u003Cbr\u003EСопутствующие противоэпилептические препараты (в период перевода пациентов на терапию леветирацетамом) желательно отменять постепенно.\u003Cbr\u003EПочечная недостаточность\u003Cbr\u003EПрименение леветирацетама у пациентов с почечной недостаточностью может потребовать коррекции дозы. У пациентов с тяжелой печеночной недостаточностью рекомендуется оценивать функцию почек до начала подбора дозы (см. раздел «Способ применения и дозы»).\u003Cbr\u003EСуицид\u003Cbr\u003EУ пациентов, принимавших противосудорожные средства (включая леветирацетам), отмечались суицид, попытки суицида, суицидальные мысли и поведение. В связи с вышеизложенным необходимо осуществлять наблюдение за пациентами с симптомами депрессии или суицидальных мыслей и поведения и назначать им соответствующую терапию. Пациентов (и лицам, ухаживающим за ними) следует проинформировать о необходимости обращения за медицинской помощью при возникновении у них симптомов депрессии и (или) суицидальных мыслей и поведения.\u003Cbr\u003EДети\u003Cbr\u003EТаблетки не предназначены для применения у детей в возрасте младше 6 лет. Для детей младше 6 лет рекомендуемой лекарственной формой является раствор для приема внутрь.\u003Cbr\u003EПо имеющимся данным леветирацетам не влияет на рост и половое созревание. Однако долгосрочное влияние на обучение, интеллект, рост, эндокринную функцию, половое созревание и фертильность детей не известно."},{"name":"Взаимодействие","value":"Препарат не взаимодействует с противоэпилептическими препаратами (фенитоин, карбамазепин, вальпроевая кислота, фенобарбитал, ламотриджин, габапентин и прими дон).\u003Cbr\u003EЛеветирацетам в суточной дозе 1000 мг не изменяет фармакокинетику пероральных противозачаточных средств (этинилэстрадиола и левоноргестрела).\u003Cbr\u003EЛеветирацетам в суточной дозе 2000 мг не изменяет фармакокинетику дигоксина и варфарина.\u003Cbr\u003EДигоксин, пероральные противозачаточные средства и варфарин не влияют на фармакокинетику леветирацетама.\u003Cbr\u003EПри совместном приеме с топираматом выше вероятность развития анорексии.\u003Cbr\u003EПолнота всасывания леветирацетама не изменяется под воздействием пищи, при этом скорость всасывания несколько снижается.\u003Cbr\u003EДанных о взаимодействии леветирацетама с алкоголем нет.\u003Cbr\u003EКлиренс леветирацетама был выше на 20% у детей, принимающих противосудорожные средства - индукторы микросомального окисления в печени, по сравнении с детьми, их не принимающими. Снижение почечной секреции первичного метаболита наблюдалось при приеме пробенецида в дозе 500 мг 4 раза в день."},{"name":"Регистрационный номер","value":"ЛП-002135"},{"name":"Дата государственной регистрации","value":"06.09.2021"},{"name":"Владелец регистрационного удостоверения","value":"Канонфарма продакшн"},{"name":"Изготовитель","value":"Канонфарма продакшн"},{"name":"Фасовщик","value":"Канонфарма продакшн"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Леветирацетам Канон"},{"name":"Срок годности","value":"36 мес."}]}],"transitionId":"tr_17626565562551386877"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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    Цена 785 ₽ вместо 993
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  • Леветирацетам таб. п/о плен., 250 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-8c94sw9rkun/toggleWishlist":{"skuId":"101781050731","productId":925308014,"offerId":"hAnx7bOv6N5-ut2DbTNpZQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQtIDI8eSs1dF6EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI7qicuQMQ66r+lPsCGISpsggg7dnBBw==","sign":"Itka0LGj+Pi/MH5OSBkU7vtnHPZTAAXTs85HOCaeayw="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-8c94sw9rkun/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Леветирацетам таб. п/о плен., 250 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 527 ₽
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  • Кеппра таб. п/о плен., 250 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-s7eldxok5to/toggleWishlist":{"skuId":"186920092","productId":1404748481,"offerId":"dZSjDHC85FVbhg_b_WNu0g","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQtIDI8eSs1dF6EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIwYXrnQUQnNmQWRig2q4IIO3ZwQc=","sign":"2tDsLZK1owxv7mWCIX8NT9CMk+PGitWo0qvPsIsdrnM="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-s7eldxok5to/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Кеппра таб. п/о плен., 250 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 594 ₽
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  • Кеппра таб. п/о плен., 500 мг, 60 шт.
    –17 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-28uyzqppnea/toggleWishlist":{"skuId":"660016035","productId":1404748715,"offerId":"aY1r-BrJq30Fx_WKh5uiGA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQtIDI8eSs1dF6EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIq4frnQUQo5fcugIYoNquCCDt2cEH","sign":"tHX//qeXId2z8gqfA4ciCXzOiyF/V3p/BNAQZHtstIw="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-28uyzqppnea/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Кеппра таб. п/о плен., 500 мг, 60 шт.

    Рейтинг товара: 5 из 5
    на основе 14 оценок
    Цена 2 025 ₽ вместо 2 450
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  • Леветирацетам-Алиум таб. п/о плен., 250 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-6f3gkzu92oj/toggleWishlist":{"skuId":"101640945949","productId":1734838337,"offerId":"ksQL4rvA1Glly-U0-VRLxQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQtIDI8eSs1dF6EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIwZCeuwYQnYKX0voCGLGLuggg7dnBBw==","sign":"0UF/a76Th8A/Mln0z1urbKiYFGajrDjysYcLr1W8HxA="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-6f3gkzu92oj/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Леветирацетам-Алиум таб. п/о плен., 250 мг, 30 шт.

    Рейтинг товара: 3 из 5
    на основе 1 оценка
    Цена 543 ₽
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  • Леветинол таб. п/о плен., 250 мг, 30 шт.
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    Леветинол таб. п/о плен., 250 мг, 30 шт.

    Рейтинг товара: 4.5 из 5
    на основе 45 оценок
    Цена 528 ₽
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  • Оланзапин канон таб. п/о плен., 5 мг, 28 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-8r93igvp0f5/toggleWishlist":{"skuId":"228063046","productId":1404748544,"offerId":"5XVRtrVf8STjEPoHTMKKaA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQtIDI8eSs1dF6EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIgIbrnQUQxu7fbBjOwtkHIO3ZwQc=","sign":"p0L4HQ3vqYYp855kxyiIs7hx+j8RLXDWPJTUQSEID1g="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-8r93igvp0f5/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Оланзапин канон таб. п/о плен., 5 мг, 28 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 277 ₽
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  • Кеппра р-р д/вн. приема, 100 мг/мл, 300 мл, 1 шт.
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    Кеппра р-р д/вн. приема, 100 мг/мл, 300 мл, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 2 097 ₽
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  • Габапентин Канон капс., 300 мг, 30 шт.
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    Габапентин Канон капс., 300 мг, 30 шт.

    Рейтинг товара: 4.9 из 5
    на основе 153 оценки
    Цена 282 ₽
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  • Депакин Хроно таб. пролонг. п/о, 500 мг, 30 шт.
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    Депакин Хроно таб. пролонг. п/о, 500 мг, 30 шт.

    Рейтинг товара: 4.6 из 5
    на основе 14 оценок
    Цена 243 ₽
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  • Кеппра конц. д/приг. р-ра д/инф., 100 мг/мл, 5 мл, 10 шт.
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    Кеппра конц. д/приг. р-ра д/инф., 100 мг/мл, 5 мл, 10 шт.

    Рейтинг товара: 4 из 5
    на основе 1 оценка
    Цена 4 760 ₽
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  • Топирамат Канон таб. п/о плен., 25 мг, 28 шт.
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    Топирамат Канон таб. п/о плен., 25 мг, 28 шт.

    Рейтинг товара: 4.7 из 5
    на основе 21 оценка
    Цена 235 ₽
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Инструкция

Показания к применению

В качестве монотерапии (препарат первого выбора) при лечении
парциальных припадков с вторичной генерализацией или без таковой у взрослых и подростков старше 16 лет с вновь диагностированной эпилепсией.
В составе комплексной терапии при лечении
парциальных припадков с вторичной генерализацией или без таковой у взрослых и детей старше 6 лет, страдающих эпилепсией;
миоклонических судорог у взрослых и подростков старше 12 лет, страдающих ювенильной миоклонической эпилепсией;
первично-генерализованных судорожных (тонико-клонических) припадков у взрослых и подростков старше 12 лет, страдающих идиопатической генерализованной эпилепсией.

Противопоказания

Повышенная чувствительность к леветирацетаму или другим производным пирролидона, а также к любым компонентам препарата.

Способ применения и дозы

Внутрь, независимо от приема пищи, запивая достаточным количеством жидкости. Суточную дозу препарата делят на два приема в одинаковой дозе.
Монотерапия
Взрослым и подросткам старше 16 лет лечение следует начинать с суточной дозы 500 мг, разделенной на 2 приема (по 250 мг 2 раза в сутки). Через 2 недели доза может быть увеличена до начальной терапевтической - 1000 мг (по 500 мг 2 раза в сутки). Максимальная суточная доза составляет 3000 мг (по 1500 мг 2 раза в сутки).
В составе комплексной терапии
Детям старше 6 лет лечение следует начинать с суточной дозы 20 мг/кг массы тела, разделенной на 2 приема (по 10 мг/кг массы тела 2 раза в сутки). Изменение дозы на 20 мг/кг массы тела может осуществляться каждые 2 недели до достижения рекомендуемой суточной дозы - 60 мг/кг массы тела (по 30 мг/кг массы тела 2 раза в сутки). При непереносимости рекомендуемой суточной дозы возможно ее снижение. Следует применять минимальную эффективную дозы. Врач должен назначить препарат в наиболее подходящей дозировке в зависимости от массы тела пациента и необходимой терапевтической дозы.
Детям с массой тела более 50 кг дозирование осуществляется по схеме, приведенной для взрослых.
Взрослым и подросткам старше 16 лет с массой тела более 50 кг лечение следует начинать с суточной дозы 1000 мг, разделенной на 2 приема (по 500 мг 2 раза в сутки). В зависимости от клинической реакции и переносимости препарата суточная доза может быть увеличена до максимальной - 3000 мг (по 1500 мг 2 раза в сутки). Изменение дозы на 500 мг 2 раза в сутки может осуществляться каждые 2-4 недели.
Поскольку леветирацетам выводится из организма почками, при назначении препарата пациентам с почечной недостаточностью и пациентам пожилого возраста дозу следует корректировать в зависимости от величины клиренса креатинина (КК).
Полная инструкция
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Леветирацетам Канон таб. п/о плен.
Леветирацетам Канон таб. п/о плен., 1000 мг, 30 шт.
4.9
(25)
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1 вопрос
Инструкция

790 ₽

Скидка: 21%
–21 %
Вместо:1 000 ₽
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4.9
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У продавца:25 оценок·6 отзывов
У всех продавцов:153 оценки·39 отзывов
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user avatar
2 месяца назад • Андрей Ш. • Куплен на Маркете
Достоинства: Действует быстро. Нет привыкания. Доза, необходимая для положительного эффекта, держится стабильная.
Недостатки: Не всегда есть в продаже. Продаётся строго по рецепту.
Комментарий: Очень хороший препарат. Мне выписали разовую дозу в 500 мг 2 раза в день. Но я покупаю эту дозировку в 1000 мг в таблетке и просто делю её на два приёма. Получается в разы дешевле, если бы покупал упаковки с дозировкой в 500 мг.
user avatar
5 месяцев назад • игорь к. • Куплен на Маркете
Достоинства: цена
Недостатки: нет
Комментарий: Единственное место, где нашли дозировку 1000. Удобное местоположение аптеки. Моей собаке эти таблетки назначены пожизненно, так что буду заказывать ещё. Спасибо продавцу!
user avatar
10 месяцев назад • Имя скрыто • Куплен на Маркете
Достоинства: Приемлемая цена и возможность доставки в удобное место
Комментарий: Отличный препарат, никаких побочек не вызывает
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