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Описание

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Ко-тримоксазол таб., 480 мг, 20 шт.

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4.7
(28)
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Коротко о товаре

Артикул Маркета
4453152182
Тип препарата
Назначение
Действующее вещество
Возраст
от 6 лет
Инструкция
{"widgets":{"@card/SpecsList":{"/content/page/fancyPage/productSpecsList":{"wrapperProps":{"margins":{"top":4,"bottom":4}},"specsLimit":5,"title":"Коротко о товаре","titleSize":"14","type":"minimal","offset":"s","isHealthCategory":true,"forceShowWidget":true,"withFridge":true}}},"meta":{"/content/page/fancyPage/productSpecsList":{"name":"@card/SpecsList"}},"collections":{"minimalSpecs":{"7456257381279071694":{"specItems":[{"name":"Артикул Маркета","value":"4453152182","withCopyValueButton":true},{"name":"тип препарата","value":"рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"назначение","value":"ангина, бронхит, бронхоэктатическая болезнь, бруцеллез, брюшной тиф, гастроэнтерит, гонорея, дизентерия, инфицированные раны и нарывы, ларингит, малярия, мягкий шанкр, остеомиелит, пиелонефрит, пиодермия, пневмония, простатит, синусит, скарлатина, средний отит, угревая болезнь, уретрит, фурункулез, холангит, холера, холецистит","transition":{"type":"list","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["36476390:36619070,36619067,36619002,36618837,36618778,36618771,36618733,36618691,36618604,36618515,36618468,36618331,36618328,36618327,36618274,36618241,36618226,36618146,36617958,36617929,36617928,36617765,36617752,36617612,36617320,36617299"]}}},{"name":"действующее вещество","value":"Ко-тримоксазол","transition":{"type":"list","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["27144131:28708470"]}}},{"name":"возраст","value":"от 6 лет"},{"name":"форма выпуска","value":"таблетки"},{"name":"страна-производитель","value":"Россия"}]}},"compactSpecs":{"7456257381279071694":{"specItems":[{"name":"Артикул Маркета","value":"4453152182","withCopyValueButton":true},{"name":"Тип препарата","value":"Рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"Действующее вещество","value":"Ко-тримоксазол","transition":{"type":"list","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["27144131:28708470"]}}},{"name":"Возраст","value":"От 6 лет"},{"name":"Форма выпуска","value":"Таблетки"}]}},"fullSpecs":{"7456257381279071694":{"specItems":[{"name":"Тип препарата","value":"лекарственный препарат","transition":{"type":"catalog","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["34324371:35649313"]}}},{"name":"Рецептурный препарат","value":"да","transition":{"type":"catalog","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["27272850:1,0"]}}},{"name":"Назначение","value":"ангина, бронхит, бронхоэктатическая болезнь, бруцеллез, брюшной тиф, гастроэнтерит, гонорея, дизентерия, инфицированные раны и нарывы, ларингит, малярия, мягкий шанкр, остеомиелит, пиелонефрит, пиодермия, пневмония, простатит, синусит, скарлатина, средний отит, угревая болезнь, уретрит, фурункулез, холангит, холера, холецистит","transition":{"type":"catalog","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["36476390:36619070,36619067,36619002,36618837,36618778,36618771,36618733,36618691,36618604,36618515,36618468,36618331,36618328,36618327,36618274,36618241,36618226,36618146,36617958,36617929,36617928,36617765,36617752,36617612,36617320,36617299"]}}},{"name":"Органы и системы","value":"дыхательная система, желудок, желчный пузырь и желчевыводящие пути, кишечник, кожа, мочевой пузырь, мочеточники, половая система, почки, уши"},{"name":"Показания к применению","value":"- Инфекции мочеполовых органов: уретрит, цистит, пиелит, пиелонефрит, простатит, эпидидимит, гонорея, мягкий шанкр, венерическая лимфогранулема, паховая гранулема;\u003Cbr\u003E- инфекции дыхательных путей: бронхит (острый и хронический), бронхоэктатическая болезнь, крупозная пневмония, бронхопневмония, пневмоцистная пневмония;\u003Cbr\u003E- инфекции ЛОР-органов: средний отит, синусит, ларингит, ангина; скарлатина; инфекции желудочно-кишечного тракта: брюшной тиф, паратиф, сальмонеллоносительство, холера, дизентерия, холецистит, холангит, гастроэнтериты, вызванные энтеротоксичными штаммами Escherichia coli;\u003Cbr\u003E- инфекции кожи и мягких тканей: акне, фурункулез, пиодермия, раневые инфекции; - остеомиелит (острый и хронический) и др. остеоартикулярные инфекции, бруцеллез (острый), южноамериканский бластомикоз, малярия (Plasmodium falciparum), токсоплазмоз (в составе комплексной терапии)."},{"name":"Противопоказания","value":"Повышенная чувствительность к ко-тримоксазолу, триметоприму, сульфаниламидам или какому-либо составляющему препарата, беременность, период грудного вскармливания, детский возраст до 6 лет (для данной лекарственной формы), установленный диагноз повреждения паренхимы печени, тяжелая почечная недостаточность если нет возможности определения концентрации препарата в плазме крови (не рекомендуется применение при клиренсе креатинина ниже 15 мл/мин), тяжелые гематологические заболевания (апластическая анемия, В12-дефицитная анемия, агранулоцитоз, лейкопения, меголобластная анемия, гипербилирубинемия у детей, связанная с дефицитом фолиевой кислоты), дефицит глюкозо-6-фосфатдегидрогеназы (вероятность развития гемолиза); одновременный прием с дофетилидом, паклитакселом и амиодароном; следует избегать одновременного применения с клозапином, поскольку известна способность последнего вызывать агранулоцитоз."},{"name":"Состав","value":"На одну таблетку:\u003Cbr\u003Eдействующие вещества: сульфаметоксазол - 400 мг, триметоприм - 80 мг;\u003Cbr\u003Eвспомогательные вещества: крахмал картофельный - 98 мг, повидон (поливинилпирролидон, повидон К-17) - 5,5 мг, кроскармеллоза натрия - 12,0 мг, кальция стеарат - 4,5 мг."},{"name":"Действующее вещество","value":"Ко-тримоксазол","transition":{"type":"catalog","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["27144131:28708470"]}}},{"name":"Способ применения и дозы","value":"Препарат принимают во время или после еды. Рекомендуется запивать щелочным питьем (молоком, минеральной водой).\u003Cbr\u003EРежим дозирования индивидуальный в зависимости от тяжести заболевания, чувствительности и вида возбудителя, возраста больного.\u003Cbr\u003EДетям от 6 до 12 лет: по 1 таблетке (480 мг) 2 раза в день.\u003Cbr\u003EВзрослым и детям старше 12 лет: по 2 таблетки (960 мг) однократно или по 1 таблетке 2 раза в сутки.\u003Cbr\u003EПри тяжелом течении инфекций - по 1 таблетке 3 раза в сутки, при хронических инфекциях поддерживающая доза - 1 таблетка 2 раза в сутки.\u003Cbr\u003EПри неосложненных инфекциях назначают: старше 12 лет и взрослым по 1 таблетке 2 раза в сутки. Продолжительность курса лечения от 5 до 14 дней.\u003Cbr\u003EПри тяжелом течении и/или при хронической форме инфекционных заболеваний допустимо увеличение разовой дозы на 30-50%."},{"name":"Побочные действия","value":"Со стороны нервной системы: головная боль, головокружение, вертиго, судороги, атаксия, парестезия, звон в ушах, увеит, галлюцинации, нервозность; асептический менингит, депрессия, апатия, тремор, периферические невриты.\u003Cbr\u003EСо стороны дыхательной системы: бронхоспазм, легочные инфильтраты: эозинофильный инфильтрат, аллергический альвеолит (кашель, одышка).\u003Cbr\u003EСо стороны пищеварительной системы: тошнота, рвота, снижение аппетита, диарея, гастрит, боль в животе, глоссит, стоматит, холестаз, повышение активности \"печеночных\" трансаминаз, гепатит в т.ч. холестатический, гепатонекроз, псевдомембранозный колит, синдром \"исчезающего желчного протока\" (дуктопения), гипербилирубинемия, острый панкреатит.\u003Cbr\u003EСо стороны органов кроветворения: лейкопения, нейтропения, тромбоцитопения, агранулоцитоз, анемия (мегалобластная, гемолитическая/аутоимунная или апластическая), метгемоглобинемия, эозинофилия, гипопротромбинемия.\u003Cbr\u003EСо стороны мочевыделительной системы: полиурия, интерстициальный нефрит, нарушение функции почек, кристаллурия, гематурия, повышение концентрации мочевины, гиперкреатининемия, токсическая нефропатия с олигурией и анурией.\u003Cbr\u003EСо стороны опорно-двигательного аппарата: артралгия, миалгия, рабдомиолиз. Аллергические реакции: зуд, фотосенсибилизация, сыпь, мультиформная экссудативная эритема (в т.ч. синдром Стивена-Джонсона), токсический эпидермальный некролиз (синдром Лайелла), эксфолиативный дерматит, аллергический миокардит, повышение температуры тела, ангионевротический отек, гиперемия склер, крапивница, гиперемия конъюнктивы, анафилактические/анафилактоидные реакции, сывороточная болезнь, геморрагический васкулит (пурпура Шенлейн-Геноха), узелковый периартерит, волчаночноподобный синдром, лекарственная сыпь с эозинофилией и системной симптоматикой (DRESS-синдром).\u003Cbr\u003EПрочие: гипогликемий, гиперкалиемия (главным образом у пациентов с СПИДом при терапии пневмоцистной пневмонии), гипонатриемия, слабость, усталость, бессонница, кандидоз."},{"name":"Фармакологическое действие","value":"Комбинированный противомикробный препарат, состоящий из сульфаметоксазола и триметоприма.\u003Cbr\u003EСульфаметоксазол, сходный по строению с парааминобензойной кислотой, нарушает синтез дигидрофолиевой кислоты в бактериальных клетках, препятствуя включению парааминобензойной кислоты в ее молекулу.\u003Cbr\u003EТриметоприм усиливает действие сульфаметоксазола, нарушая восстановление дигидрофолиевой кислоты в тетрагидрофолиевую - активную форму фолиевой кислоты, ответственную за белковый обмен и деление микробной клетки.\u003Cbr\u003EЯвляется бактерицидным препаратом широкого спектра действия, активен в отношении следующих микроорганизмов: Streptococcus spp. (гемолитические штаммы более чувствительны к пенициллину), Staphylococcus spp., Streptococcus pneumoniae, Neisseria meningitidis, Neisseria gonorrhoeae, Escherichia coli (включая энтеротоксогенные штаммы), Salmonella spp. (включая Salmonella typhi и Salmonella paratyphi), Vibrio cholerae, Bacillus anthracis, Haemophilus influenzae (включая ампициллиноустойчивые штаммы), Listeria spp., Nocardia asteroides, Bordetella pertussis, Enterococcus faecalis, Klebsiella spp., Proteus spp., Pasteurella spp., Francisella tularensis, Brucella spp., Mycobacterium spp. (в т.ч. Mycobacterium leprae), Citrobacter, Enterobacter spp., Legionella pneumophila, Providencia, некоторые виды Pseudomonas (кроме Pseudomonas aeruginosa), Serratia marcescens, Shigella spp., Yersinia spp., Morganella spp., Pneumocystis carinii; Chlamydia spp. (в т.ч. Chlamydia trachomatis, Chlamydia psittaci); простейшие: Plasmodium spp., Toxoplasma gondii, патогенные грибы, Actinomyces israelii, Coccidioides immitis, Histoplasma capsulatum, Leishmania spp.\u003Cbr\u003EУстойчивы к препарату: Corynebacterium spp., Pseudomonas aeruginosa, Mycobacterium tuberculosis, Treponema spp., Leptospira spp., вирусы.\u003Cbr\u003EУгнетает жизнедеятельность кишечной палочки, что приводит к уменьшению синтеза тиамина, рибофлавина, никотиновой кислоты и др. витаминов группы В в кишечнике.\u003Cbr\u003EПродолжительность терапевтического эффекта составляет 7 ч."},{"name":"Фармакологическая группа","value":"противомикробное средство комбинированное"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 6 лет"},{"name":"Условия хранения","value":"Хранить при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы: тошнота, рвота, кишечная колика, головокружение, головная боль, сонливость, депрессия, обморочные состояния, спутанность сознания, нарушение зрения, лихорадка, гематурия, кристаллурия; при продолжительной передозировке - тромбоцитопения, лейкопения, мегалобластная анемия, желтуха.\u003Cbr\u003EЛечение: промывание желудка, подкисление мочи увеличивает выведение триметоприма, прием жидкости внутрь, в/м - 5-15 мг/сут кальция фолината (устраняет действие триметоприма на костный мозг), при необходимости - гемодиализ."},{"name":"Применение при беременности и кормлении грудью","value":"В связи с тем, что безопасность применения ко-тримоксазола у беременных женщин не установлена, применение препарата при беременности противопоказано.\u003Cbr\u003EИзвестно, что триметоприм и сульфаметоксазол проникают в грудное молоко, поэтому при необходимости применения препарата в период лактации следует решить вопрос об отмене грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения следует соблюдать осторожность при управлении транспортными средствами и занятиями другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций. Следует принимать во внимание потенциальную возможность развития побочных эффектов со стороны нервной системы, таких как головокружение, вертиго, судороги, галлюцинации. При появлении описанных побочных эффектов следует воздержаться от выполнения указанных видов деятельности."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EДефицит фолиевой кислоты, бронхиальная астма, заболевания щитовидной железы.\u003Cbr\u003EКо-тримоксазол следует назначать только в тех случаях, когда преимущество такой комбинированной терапии перед другими антибактериальными монопрепаратами превышает возможный риск. Поскольку чувствительность бактерий к антибактериальным препаратам in vitro изменяется в разных географических областях и во времени, при выборе препарата следует учитывать местные особенности бактериальной чувствительности.\u003Cbr\u003EГиперчувствительность и аллергические реакции: при первом появлении кожной сыпи или любой другой тяжелой побочной реакции препарат следует отменить. Пациентам со склонностью к аллергическим реакциям и с бронхиальной астмой ко-тримоксазол следует назначать с осторожностью.\u003Cbr\u003EИнфильтраты в легких (по типу эозинофильного или аллергического альвеолита) могут проявляться такими симптомами как кашель или одышка. При появлении или внезапном нарастании указанных симптомов необходимо повторно обследовать пациента и рассмотреть вопрос о прекращении лечения препаратом.\u003Cbr\u003EНарушения со стороны почек: сульфонамиды, включая препарат Ко-тримоксазол, могут усиливать диурез, особенно у пациентов с отеками, вызванными сердечной недостаточностью. Тщательный контроль функции почек и концентрации калия в сыворотке крови необходим пациентам, получающим высокие дозы Ко-тримоксазола (в том числе при терапии пневмоцистной пневмонии, вызванной Р. jirovecii), а также следующим группам пациентов: пациентам с нарушением метаболизма калия в анамнезе, получающим стандартные дозы Ко-тримоксазола; пациентам с почечной недостаточностью; пациентам, получающим препараты, способствующие развитию гиперкалиемии.\u003Cbr\u003EСерьезные нежелательные реакции: сообщалось о летальных исходах, хотя и редких, связанных с такими побочными реакциями, как патологические изменения крови, синдром Стивенса-Джонсона, токсический эпидермальный некролиз (синдром Лайелла), лекарственная сыпь с эозинофилией и системными проявлениями (DRESS синдром), и молниеносный некроз печени.\u003Cbr\u003EОсобые группы пациентов: у пациентов пожилого и старческого возраста, а также у пациентов с сопутствующими заболеваниями, например, нарушением функции почек и/или печени, либо при одновременном приеме других препаратов, существует повышенный риск тяжелых побочных реакций. В этих случаях риск развития связан с дозой и продолжительностью терапии.\u003Cbr\u003EПродолжительность лечения препаратом должна быть как можно более короткой, особенно у пациентов пожилого и старческого возраста.\u003Cbr\u003EПри нарушении функции почек дозу следует скорректировать согласно указаниям раздела \"Способ применения и дозы\". Пациентов с нарушением функции почек тяжелой степени (клиренс креатинина 15-30 мл/мин), получающих триметоприм-сульфаметоксазол, необходимо тщательно мониторировать на предмет развития симптомов токсичности (тошнота, рвота, гиперкалиемия).\u003Cbr\u003EПациентам с тяжелыми гематологическими заболеваниями препарат Ко-тримоксазол можно назначать лишь в виде исключения.\u003Cbr\u003EУ пациентов пожилого и старческого возраста, а также у пациентов с уже имеющимся дефицитом фолиевой кислоты или почечной недостаточностью, могут возникнуть гематологические изменения, характерные для недостатка фолиевой кислоты. Они исчезают после назначения фолиевой кислоты.\u003Cbr\u003EИз-за возможности гемолиза Ко-тримоксазол не следует назначать пациентам с дефицитом глюкозо-6-фосфатдегидрогеназы, за исключением наличия абсолютных показаний и только в минимальных дозах.\u003Cbr\u003EКак и при назначении любых сульфонамидов, необходимо соблюдать осторожность у пациентов с порфирией или нарушением функции щитовидной железы.\u003Cbr\u003EПациенты, для обмена веществ которых характерно \"медленное ацетилирование\", более склонны к развитию идиосинкразии к сульфонамидам.\u003Cbr\u003EДлительная терапия: при длительном назначении Ко-тримоксазола необходимо регулярно определять число форменных элементов крови. При значительном снижении числа любых клеток крови препарат следует отменить.\u003Cbr\u003EПациентам, длительно получающим лечение препаратом Ко-тримоксазол (особенно при почечной недостаточности), необходимо регулярно делать общий анализ мочи и контролировать функцию почек. Во время лечения нужно обеспечить достаточное поступление жидкости в организм и адекватный диурез для предотвращения кристаллурии.\u003Cbr\u003EВлияние на результаты лабораторных исследований:Триметоприм может изменить результаты определения уровня метотрексата в сыворотке, проводимого энзиматическим методом, однако не влияет на результат при выборе радиоиммунологического метода. Ко-тримоксазол может повышать на 10% результаты реакции Яффе с пикриновой кислотой для количественного определения креатинина."},{"name":"Взаимодействие","value":"Увеличивает антикоагулянтную активность непрямых антикоагулянтов, а также действие гипогликемических лекарственных средств и метотрексата.\u003Cbr\u003EСнижает интенсивность печеночного метаболизма фенитоина (удлиняет его период полувыведения на 39%) и варфарина, усиливая их эффект.\u003Cbr\u003EСнижает надежность пероральной контрацепции (угнетает кишечную микрофлору и уменьшает кишечно-печеночную циркуляцию гормональных соединений).\u003Cbr\u003EРифампицин сокращает период полувыведения триметоприма.\u003Cbr\u003EПириметамин в дозах, превышающих 25 мг/нед, увеличивает риск развития мегалобластной анемии.\u003Cbr\u003EДиуретики (чаще тиазиды) увеличивают риск развития тромбоцитопении. Снижают эффект бензокаин, прокаин, прокаинамид (и др. лекарственные средства, в результате гидролиза которых образуется парааминобензойная кислота). Между диуретиками (тиазиды, фуросемид и др.) и пероральными гипогликемическими лекарственными средствами (производные сульфонилмочевины), с одной стороны, и противомикробными сульфаниламидами - с др., возможно развитие перекрестной аллергической реакции.\u003Cbr\u003EФенитоин, барбитураты, парааминобензойная кислота усиливают проявления дефицита фолиевой кислоты.\u003Cbr\u003EПроизводные салициловой кислоты усиливают действие.\u003Cbr\u003EАскорбиновая кислота, гексаметилентетрамин (и др. лекарственные средства, закисляющие мочу) увеличивают риск развития кристаллурии.\u003Cbr\u003EКолестирамин снижает абсорбцию, поэтому его следует принимать через 1 ч после или за 4-6 ч до приема ко-тримоксазола.\u003Cbr\u003EЛекарственные средства, угнетающие костномозговое кроветворение, увеличивают риск миелосупрессии."},{"name":"Регистрационный номер","value":"P N000700/01"},{"name":"Дата государственной регистрации","value":"28.01.2019"},{"name":"Владелец регистрационного удостоверения","value":"Фармстандарт-Лексредства","transition":{"type":"catalog","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["34324371:35649313","7893318:16227855"]}}},{"name":"Изготовитель","value":"Фармстандарт-Лексредства"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Ко-тримоксазол","transition":{"type":"catalog","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["17796364:18047340"]}}},{"name":"Срок годности","value":"37 мес."}]}},"fullSpecsGrouped":{"7456257381279071694":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Назначение","value":"ангина, бронхит, бронхоэктатическая болезнь, бруцеллез, брюшной тиф, гастроэнтерит, гонорея, дизентерия, инфицированные раны и нарывы, ларингит, малярия, мягкий шанкр, остеомиелит, пиелонефрит, пиодермия, пневмония, простатит, синусит, скарлатина, средний отит, угревая болезнь, уретрит, фурункулез, холангит, холера, холецистит"},{"name":"Органы и системы","value":"дыхательная система, желудок, желчный пузырь и желчевыводящие пути, кишечник, кожа, мочевой пузырь, мочеточники, половая система, почки, уши"},{"name":"Показания к применению","value":"- Инфекции мочеполовых органов: уретрит, цистит, пиелит, пиелонефрит, простатит, эпидидимит, гонорея, мягкий шанкр, венерическая лимфогранулема, паховая гранулема;\u003Cbr\u003E- инфекции дыхательных путей: бронхит (острый и хронический), бронхоэктатическая болезнь, крупозная пневмония, бронхопневмония, пневмоцистная пневмония;\u003Cbr\u003E- инфекции ЛОР-органов: средний отит, синусит, ларингит, ангина; скарлатина; инфекции желудочно-кишечного тракта: брюшной тиф, паратиф, сальмонеллоносительство, холера, дизентерия, холецистит, холангит, гастроэнтериты, вызванные энтеротоксичными штаммами Escherichia coli;\u003Cbr\u003E- инфекции кожи и мягких тканей: акне, фурункулез, пиодермия, раневые инфекции; - остеомиелит (острый и хронический) и др. остеоартикулярные инфекции, бруцеллез (острый), южноамериканский бластомикоз, малярия (Plasmodium falciparum), токсоплазмоз (в составе комплексной терапии)."},{"name":"Противопоказания","value":"Повышенная чувствительность к ко-тримоксазолу, триметоприму, сульфаниламидам или какому-либо составляющему препарата, беременность, период грудного вскармливания, детский возраст до 6 лет (для данной лекарственной формы), установленный диагноз повреждения паренхимы печени, тяжелая почечная недостаточность если нет возможности определения концентрации препарата в плазме крови (не рекомендуется применение при клиренсе креатинина ниже 15 мл/мин), тяжелые гематологические заболевания (апластическая анемия, В12-дефицитная анемия, агранулоцитоз, лейкопения, меголобластная анемия, гипербилирубинемия у детей, связанная с дефицитом фолиевой кислоты), дефицит глюкозо-6-фосфатдегидрогеназы (вероятность развития гемолиза); одновременный прием с дофетилидом, паклитакселом и амиодароном; следует избегать одновременного применения с клозапином, поскольку известна способность последнего вызывать агранулоцитоз."},{"name":"Состав","value":"На одну таблетку:\u003Cbr\u003Eдействующие вещества: сульфаметоксазол - 400 мг, триметоприм - 80 мг;\u003Cbr\u003Eвспомогательные вещества: крахмал картофельный - 98 мг, повидон (поливинилпирролидон, повидон К-17) - 5,5 мг, кроскармеллоза натрия - 12,0 мг, кальция стеарат - 4,5 мг."},{"name":"Действующее вещество","value":"Ко-тримоксазол"},{"name":"Способ применения и дозы","value":"Препарат принимают во время или после еды. Рекомендуется запивать щелочным питьем (молоком, минеральной водой).\u003Cbr\u003EРежим дозирования индивидуальный в зависимости от тяжести заболевания, чувствительности и вида возбудителя, возраста больного.\u003Cbr\u003EДетям от 6 до 12 лет: по 1 таблетке (480 мг) 2 раза в день.\u003Cbr\u003EВзрослым и детям старше 12 лет: по 2 таблетки (960 мг) однократно или по 1 таблетке 2 раза в сутки.\u003Cbr\u003EПри тяжелом течении инфекций - по 1 таблетке 3 раза в сутки, при хронических инфекциях поддерживающая доза - 1 таблетка 2 раза в сутки.\u003Cbr\u003EПри неосложненных инфекциях назначают: старше 12 лет и взрослым по 1 таблетке 2 раза в сутки. Продолжительность курса лечения от 5 до 14 дней.\u003Cbr\u003EПри тяжелом течении и/или при хронической форме инфекционных заболеваний допустимо увеличение разовой дозы на 30-50%."},{"name":"Побочные действия","value":"Со стороны нервной системы: головная боль, головокружение, вертиго, судороги, атаксия, парестезия, звон в ушах, увеит, галлюцинации, нервозность; асептический менингит, депрессия, апатия, тремор, периферические невриты.\u003Cbr\u003EСо стороны дыхательной системы: бронхоспазм, легочные инфильтраты: эозинофильный инфильтрат, аллергический альвеолит (кашель, одышка).\u003Cbr\u003EСо стороны пищеварительной системы: тошнота, рвота, снижение аппетита, диарея, гастрит, боль в животе, глоссит, стоматит, холестаз, повышение активности \"печеночных\" трансаминаз, гепатит в т.ч. холестатический, гепатонекроз, псевдомембранозный колит, синдром \"исчезающего желчного протока\" (дуктопения), гипербилирубинемия, острый панкреатит.\u003Cbr\u003EСо стороны органов кроветворения: лейкопения, нейтропения, тромбоцитопения, агранулоцитоз, анемия (мегалобластная, гемолитическая/аутоимунная или апластическая), метгемоглобинемия, эозинофилия, гипопротромбинемия.\u003Cbr\u003EСо стороны мочевыделительной системы: полиурия, интерстициальный нефрит, нарушение функции почек, кристаллурия, гематурия, повышение концентрации мочевины, гиперкреатининемия, токсическая нефропатия с олигурией и анурией.\u003Cbr\u003EСо стороны опорно-двигательного аппарата: артралгия, миалгия, рабдомиолиз. Аллергические реакции: зуд, фотосенсибилизация, сыпь, мультиформная экссудативная эритема (в т.ч. синдром Стивена-Джонсона), токсический эпидермальный некролиз (синдром Лайелла), эксфолиативный дерматит, аллергический миокардит, повышение температуры тела, ангионевротический отек, гиперемия склер, крапивница, гиперемия конъюнктивы, анафилактические/анафилактоидные реакции, сывороточная болезнь, геморрагический васкулит (пурпура Шенлейн-Геноха), узелковый периартерит, волчаночноподобный синдром, лекарственная сыпь с эозинофилией и системной симптоматикой (DRESS-синдром).\u003Cbr\u003EПрочие: гипогликемий, гиперкалиемия (главным образом у пациентов с СПИДом при терапии пневмоцистной пневмонии), гипонатриемия, слабость, усталость, бессонница, кандидоз."},{"name":"Фармакологическое действие","value":"Комбинированный противомикробный препарат, состоящий из сульфаметоксазола и триметоприма.\u003Cbr\u003EСульфаметоксазол, сходный по строению с парааминобензойной кислотой, нарушает синтез дигидрофолиевой кислоты в бактериальных клетках, препятствуя включению парааминобензойной кислоты в ее молекулу.\u003Cbr\u003EТриметоприм усиливает действие сульфаметоксазола, нарушая восстановление дигидрофолиевой кислоты в тетрагидрофолиевую - активную форму фолиевой кислоты, ответственную за белковый обмен и деление микробной клетки.\u003Cbr\u003EЯвляется бактерицидным препаратом широкого спектра действия, активен в отношении следующих микроорганизмов: Streptococcus spp. (гемолитические штаммы более чувствительны к пенициллину), Staphylococcus spp., Streptococcus pneumoniae, Neisseria meningitidis, Neisseria gonorrhoeae, Escherichia coli (включая энтеротоксогенные штаммы), Salmonella spp. (включая Salmonella typhi и Salmonella paratyphi), Vibrio cholerae, Bacillus anthracis, Haemophilus influenzae (включая ампициллиноустойчивые штаммы), Listeria spp., Nocardia asteroides, Bordetella pertussis, Enterococcus faecalis, Klebsiella spp., Proteus spp., Pasteurella spp., Francisella tularensis, Brucella spp., Mycobacterium spp. (в т.ч. Mycobacterium leprae), Citrobacter, Enterobacter spp., Legionella pneumophila, Providencia, некоторые виды Pseudomonas (кроме Pseudomonas aeruginosa), Serratia marcescens, Shigella spp., Yersinia spp., Morganella spp., Pneumocystis carinii; Chlamydia spp. (в т.ч. Chlamydia trachomatis, Chlamydia psittaci); простейшие: Plasmodium spp., Toxoplasma gondii, патогенные грибы, Actinomyces israelii, Coccidioides immitis, Histoplasma capsulatum, Leishmania spp.\u003Cbr\u003EУстойчивы к препарату: Corynebacterium spp., Pseudomonas aeruginosa, Mycobacterium tuberculosis, Treponema spp., Leptospira spp., вирусы.\u003Cbr\u003EУгнетает жизнедеятельность кишечной палочки, что приводит к уменьшению синтеза тиамина, рибофлавина, никотиновой кислоты и др. витаминов группы В в кишечнике.\u003Cbr\u003EПродолжительность терапевтического эффекта составляет 7 ч."},{"name":"Фармакологическая группа","value":"противомикробное средство комбинированное"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 6 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Хранить при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы: тошнота, рвота, кишечная колика, головокружение, головная боль, сонливость, депрессия, обморочные состояния, спутанность сознания, нарушение зрения, лихорадка, гематурия, кристаллурия; при продолжительной передозировке - тромбоцитопения, лейкопения, мегалобластная анемия, желтуха.\u003Cbr\u003EЛечение: промывание желудка, подкисление мочи увеличивает выведение триметоприма, прием жидкости внутрь, в/м - 5-15 мг/сут кальция фолината (устраняет действие триметоприма на костный мозг), при необходимости - гемодиализ."},{"name":"Применение при беременности и кормлении грудью","value":"В связи с тем, что безопасность применения ко-тримоксазола у беременных женщин не установлена, применение препарата при беременности противопоказано.\u003Cbr\u003EИзвестно, что триметоприм и сульфаметоксазол проникают в грудное молоко, поэтому при необходимости применения препарата в период лактации следует решить вопрос об отмене грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения следует соблюдать осторожность при управлении транспортными средствами и занятиями другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций. Следует принимать во внимание потенциальную возможность развития побочных эффектов со стороны нервной системы, таких как головокружение, вертиго, судороги, галлюцинации. При появлении описанных побочных эффектов следует воздержаться от выполнения указанных видов деятельности."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EДефицит фолиевой кислоты, бронхиальная астма, заболевания щитовидной железы.\u003Cbr\u003EКо-тримоксазол следует назначать только в тех случаях, когда преимущество такой комбинированной терапии перед другими антибактериальными монопрепаратами превышает возможный риск. Поскольку чувствительность бактерий к антибактериальным препаратам in vitro изменяется в разных географических областях и во времени, при выборе препарата следует учитывать местные особенности бактериальной чувствительности.\u003Cbr\u003EГиперчувствительность и аллергические реакции: при первом появлении кожной сыпи или любой другой тяжелой побочной реакции препарат следует отменить. Пациентам со склонностью к аллергическим реакциям и с бронхиальной астмой ко-тримоксазол следует назначать с осторожностью.\u003Cbr\u003EИнфильтраты в легких (по типу эозинофильного или аллергического альвеолита) могут проявляться такими симптомами как кашель или одышка. При появлении или внезапном нарастании указанных симптомов необходимо повторно обследовать пациента и рассмотреть вопрос о прекращении лечения препаратом.\u003Cbr\u003EНарушения со стороны почек: сульфонамиды, включая препарат Ко-тримоксазол, могут усиливать диурез, особенно у пациентов с отеками, вызванными сердечной недостаточностью. Тщательный контроль функции почек и концентрации калия в сыворотке крови необходим пациентам, получающим высокие дозы Ко-тримоксазола (в том числе при терапии пневмоцистной пневмонии, вызванной Р. jirovecii), а также следующим группам пациентов: пациентам с нарушением метаболизма калия в анамнезе, получающим стандартные дозы Ко-тримоксазола; пациентам с почечной недостаточностью; пациентам, получающим препараты, способствующие развитию гиперкалиемии.\u003Cbr\u003EСерьезные нежелательные реакции: сообщалось о летальных исходах, хотя и редких, связанных с такими побочными реакциями, как патологические изменения крови, синдром Стивенса-Джонсона, токсический эпидермальный некролиз (синдром Лайелла), лекарственная сыпь с эозинофилией и системными проявлениями (DRESS синдром), и молниеносный некроз печени.\u003Cbr\u003EОсобые группы пациентов: у пациентов пожилого и старческого возраста, а также у пациентов с сопутствующими заболеваниями, например, нарушением функции почек и/или печени, либо при одновременном приеме других препаратов, существует повышенный риск тяжелых побочных реакций. В этих случаях риск развития связан с дозой и продолжительностью терапии.\u003Cbr\u003EПродолжительность лечения препаратом должна быть как можно более короткой, особенно у пациентов пожилого и старческого возраста.\u003Cbr\u003EПри нарушении функции почек дозу следует скорректировать согласно указаниям раздела \"Способ применения и дозы\". Пациентов с нарушением функции почек тяжелой степени (клиренс креатинина 15-30 мл/мин), получающих триметоприм-сульфаметоксазол, необходимо тщательно мониторировать на предмет развития симптомов токсичности (тошнота, рвота, гиперкалиемия).\u003Cbr\u003EПациентам с тяжелыми гематологическими заболеваниями препарат Ко-тримоксазол можно назначать лишь в виде исключения.\u003Cbr\u003EУ пациентов пожилого и старческого возраста, а также у пациентов с уже имеющимся дефицитом фолиевой кислоты или почечной недостаточностью, могут возникнуть гематологические изменения, характерные для недостатка фолиевой кислоты. Они исчезают после назначения фолиевой кислоты.\u003Cbr\u003EИз-за возможности гемолиза Ко-тримоксазол не следует назначать пациентам с дефицитом глюкозо-6-фосфатдегидрогеназы, за исключением наличия абсолютных показаний и только в минимальных дозах.\u003Cbr\u003EКак и при назначении любых сульфонамидов, необходимо соблюдать осторожность у пациентов с порфирией или нарушением функции щитовидной железы.\u003Cbr\u003EПациенты, для обмена веществ которых характерно \"медленное ацетилирование\", более склонны к развитию идиосинкразии к сульфонамидам.\u003Cbr\u003EДлительная терапия: при длительном назначении Ко-тримоксазола необходимо регулярно определять число форменных элементов крови. При значительном снижении числа любых клеток крови препарат следует отменить.\u003Cbr\u003EПациентам, длительно получающим лечение препаратом Ко-тримоксазол (особенно при почечной недостаточности), необходимо регулярно делать общий анализ мочи и контролировать функцию почек. Во время лечения нужно обеспечить достаточное поступление жидкости в организм и адекватный диурез для предотвращения кристаллурии.\u003Cbr\u003EВлияние на результаты лабораторных исследований:Триметоприм может изменить результаты определения уровня метотрексата в сыворотке, проводимого энзиматическим методом, однако не влияет на результат при выборе радиоиммунологического метода. Ко-тримоксазол может повышать на 10% результаты реакции Яффе с пикриновой кислотой для количественного определения креатинина."},{"name":"Взаимодействие","value":"Увеличивает антикоагулянтную активность непрямых антикоагулянтов, а также действие гипогликемических лекарственных средств и метотрексата.\u003Cbr\u003EСнижает интенсивность печеночного метаболизма фенитоина (удлиняет его период полувыведения на 39%) и варфарина, усиливая их эффект.\u003Cbr\u003EСнижает надежность пероральной контрацепции (угнетает кишечную микрофлору и уменьшает кишечно-печеночную циркуляцию гормональных соединений).\u003Cbr\u003EРифампицин сокращает период полувыведения триметоприма.\u003Cbr\u003EПириметамин в дозах, превышающих 25 мг/нед, увеличивает риск развития мегалобластной анемии.\u003Cbr\u003EДиуретики (чаще тиазиды) увеличивают риск развития тромбоцитопении. Снижают эффект бензокаин, прокаин, прокаинамид (и др. лекарственные средства, в результате гидролиза которых образуется парааминобензойная кислота). Между диуретиками (тиазиды, фуросемид и др.) и пероральными гипогликемическими лекарственными средствами (производные сульфонилмочевины), с одной стороны, и противомикробными сульфаниламидами - с др., возможно развитие перекрестной аллергической реакции.\u003Cbr\u003EФенитоин, барбитураты, парааминобензойная кислота усиливают проявления дефицита фолиевой кислоты.\u003Cbr\u003EПроизводные салициловой кислоты усиливают действие.\u003Cbr\u003EАскорбиновая кислота, гексаметилентетрамин (и др. лекарственные средства, закисляющие мочу) увеличивают риск развития кристаллурии.\u003Cbr\u003EКолестирамин снижает абсорбцию, поэтому его следует принимать через 1 ч после или за 4-6 ч до приема ко-тримоксазола.\u003Cbr\u003EЛекарственные средства, угнетающие костномозговое кроветворение, увеличивают риск миелосупрессии."},{"name":"Регистрационный номер","value":"P N000700/01"},{"name":"Дата государственной регистрации","value":"28.01.2019"},{"name":"Владелец регистрационного удостоверения","value":"Фармстандарт-Лексредства"},{"name":"Изготовитель","value":"Фармстандарт-Лексредства"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Ко-тримоксазол"},{"name":"Срок годности","value":"37 мес."}]}],"transitionId":"tr_17458251581871345749"}}}}
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    Цена 144 ₽
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  • Бисептол 480 конц. для приг. р-ра для инф. амп., 80 мг+16 мг/мл, 5 мл, 10 шт.
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    Бисептол 480 конц. для приг. р-ра для инф. амп., 80 мг+16 мг/мл, 5 мл, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 486 ₽
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  • Ко-тримоксазол сусп. д/вн. приема фл., 240 мг/5 мл, 100 г
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-u1ht9innts/toggleWishlist":{"skuId":"942487211","productId":1778177254,"offerId":"-cttea3jCHljoJYW7_yTSg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQhdnl8Ie+9vKHARIxCi9Db21wZXRpdGl2ZUFuYWxvZ3NfTWFya2V0TW9kZWxDYXJkX0Zyb250U25pcHBldDIWCOap888GEKvttMEDGI+83gcg99zBBw==","sign":"fJ+GeRwWuUKPZ0VsYZOwkodQpuR50OUYsquL3Vgq7iQ="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-u1ht9innts/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Ко-тримоксазол сусп. д/вн. приема фл., 240 мг/5 мл, 100 г

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 153 ₽
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  • Амоксициллин капс., 500 мг, 16 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ytl5s2dho2d/toggleWishlist":{"skuId":"228008983","productId":1434054467,"offerId":"u8GCX2KaObUTap74gHefyw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQhdnl8Ie+9vKHARIxCi9Db21wZXRpdGl2ZUFuYWxvZ3NfTWFya2V0TW9kZWxDYXJkX0Zyb250U25pcHBldDIVCMPe56sFEJfI3GwYnsTZByD33MEH","sign":"E/qhaBTiV3IFkMXWOcLt05eN+hMZ/YeY1Yh3v0xwWys="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ytl5s2dho2d/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Амоксициллин капс., 500 мг, 16 шт.

    Рейтинг товара: 4.9 из 5
    на основе 64 оценки
    Цена 115 ₽
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  • Ципрофлоксацин таб. п/о плен., 250 мг, 10 шт.
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    Ципрофлоксацин таб. п/о плен., 250 мг, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 20 оценок
    Цена 44 ₽
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  • Азитромицин капс., 250 мг, 6 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-7emlb17b2ut/toggleWishlist":{"skuId":"186882187","productId":1434054437,"offerId":"SpJ0LUDKY_Bz7nu0CBi7UQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQhdnl8Ie+9vKHARIxCi9Db21wZXRpdGl2ZUFuYWxvZ3NfTWFya2V0TW9kZWxDYXJkX0Zyb250U25pcHBldDIVCKXe56sFEIuxjlkY5KTVByD33MEH","sign":"QwdRzCqx8G8VBc5m1okagbrZ3tZrnDtDRaIB6IKkZwE="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-7emlb17b2ut/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Азитромицин капс., 250 мг, 6 шт.

    Рейтинг товара: 4.7 из 5
    на основе 157 оценок
    Цена 83 ₽
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  • Метронидазол таб., 250 мг, 40 шт.
    –13 %
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    Метронидазол таб., 250 мг, 40 шт.

    Рейтинг товара: 5 из 5
    на основе 15 оценок
    Цена 161 ₽ вместо 185
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  • Ципролет таб. п/о плен., 500 мг, 10 шт.
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    Ципролет таб. п/о плен., 500 мг, 10 шт.

    Рейтинг товара: 4.9 из 5
    на основе 13 оценок
    Цена 113 ₽
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  • Азитромицин капс., 250 мг, 6 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-r74nktupiu/toggleWishlist":{"skuId":"226178391","productId":1434054447,"offerId":"dbKT67w1MXmTdVGaIqWkKQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQhdnl8Ie+9vKHARIxCi9Db21wZXRpdGl2ZUFuYWxvZ3NfTWFya2V0TW9kZWxDYXJkX0Zyb250U25pcHBldDIVCK/e56sFENfq7GsYhKmyCCD33MEH","sign":"vd7qYejsOD1geuQaqV6dRidzdsLOWLMy/jNeCcbrHHI="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-r74nktupiu/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Азитромицин капс., 250 мг, 6 шт.

    Рейтинг товара: 5 из 5
    на основе 14 оценок
    Цена 94 ₽
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  • Ампициллина тригидрат таб., 250 мг, 10 шт.
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    Ампициллина тригидрат таб., 250 мг, 10 шт.

    Рейтинг товара: 4.7 из 5
    на основе 46 оценок
    Цена 34 ₽
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  • Трихопол таб., 250 мг, 20 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-zp044cub52/toggleWishlist":{"skuId":"228092185","productId":1780859035,"offerId":"NwpM6bSZZyD867P-p9ZjsQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQhdnl8Ie+9vKHARIxCi9Db21wZXRpdGl2ZUFuYWxvZ3NfTWFya2V0TW9kZWxDYXJkX0Zyb250U25pcHBldDIVCJuBl9EGEJnS4WwYud3QByD33MEH","sign":"wecuF3F1JnqMQERfe2bN4CJkHbI1ou6oSi0KVp7zWyM="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-zp044cub52/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Трихопол таб., 250 мг, 20 шт.

    Рейтинг товара: 5 из 5
    на основе 16 оценок
    Цена 96 ₽
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  • Немозол таб. п/о плен., 400 мг, 1 шт.
    –17 %
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    Немозол таб. п/о плен., 400 мг, 1 шт.

    Рейтинг товара: 4.9 из 5
    на основе 43 оценки
    Цена 326 ₽ вместо 391
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Инструкция

Показания к применению

- Инфекции мочеполовых органов: уретрит, цистит, пиелит, пиелонефрит, простатит, эпидидимит, гонорея, мягкий шанкр, венерическая лимфогранулема, паховая гранулема;
- инфекции дыхательных путей: бронхит (острый и хронический), бронхоэктатическая болезнь, крупозная пневмония, бронхопневмония, пневмоцистная пневмония;
- инфекции ЛОР-органов: средний отит, синусит, ларингит, ангина; скарлатина; инфекции желудочно-кишечного тракта: брюшной тиф, паратиф, сальмонеллоносительство, холера, дизентерия, холецистит, холангит, гастроэнтериты, вызванные энтеротоксичными штаммами Escherichia coli;
- инфекции кожи и мягких тканей: акне, фурункулез, пиодермия, раневые инфекции; - остеомиелит (острый и хронический) и др. остеоартикулярные инфекции, бруцеллез (острый), южноамериканский бластомикоз, малярия (Plasmodium falciparum), токсоплазмоз (в составе комплексной терапии).

Противопоказания

Повышенная чувствительность к ко-тримоксазолу, триметоприму, сульфаниламидам или какому-либо составляющему препарата, беременность, период грудного вскармливания, детский возраст до 6 лет (для данной лекарственной формы), установленный диагноз повреждения паренхимы печени, тяжелая почечная недостаточность если нет возможности определения концентрации препарата в плазме крови (не рекомендуется применение при клиренсе креатинина ниже 15 мл/мин), тяжелые гематологические заболевания (апластическая анемия, В12-дефицитная анемия, агранулоцитоз, лейкопения, меголобластная анемия, гипербилирубинемия у детей, связанная с дефицитом фолиевой кислоты), дефицит глюкозо-6-фосфатдегидрогеназы (вероятность развития гемолиза); одновременный прием с дофетилидом, паклитакселом и амиодароном; следует избегать одновременного применения с клозапином, поскольку известна способность последнего вызывать агранулоцитоз.

Способ применения и дозы

Препарат принимают во время или после еды. Рекомендуется запивать щелочным питьем (молоком, минеральной водой).
Режим дозирования индивидуальный в зависимости от тяжести заболевания, чувствительности и вида возбудителя, возраста больного.
Детям от 6 до 12 лет: по 1 таблетке (480 мг) 2 раза в день.
Взрослым и детям старше 12 лет: по 2 таблетки (960 мг) однократно или по 1 таблетке 2 раза в сутки.
При тяжелом течении инфекций - по 1 таблетке 3 раза в сутки, при хронических инфекциях поддерживающая доза - 1 таблетка 2 раза в сутки.
При неосложненных инфекциях назначают: старше 12 лет и взрослым по 1 таблетке 2 раза в сутки. Продолжительность курса лечения от 5 до 14 дней.
При тяжелом течении и/или при хронической форме инфекционных заболеваний допустимо увеличение разовой дозы на 30-50%.
Полная инструкция
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Ко-тримоксазол таб.
Ко-тримоксазол таб., 480 мг, 20 шт.
4.7
(28)
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1 вопрос
Инструкция

84 ₽

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4.7
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У продавца:28 оценок·5 отзывов
У всех продавцов:85 оценок·22 отзыва
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user avatar
2 месяца назад • Иван Гафин • Куплен на Маркете
Достоинства: действует отлично, эффективный препарат
Недостатки: мало точек для самовывоза
user avatar
8 месяцев назад • Любовь Еле • Куплен на Маркете
Достоинства: Отлично справляется со стрептококковой инфекцией, при красном воспаленном горле, простудных явлениях ухо-горло-нос
user avatar
8 месяцев назад • Имя скрыто • Куплен на Маркете
Достоинства: хороший аналог бисептола
Недостатки: нет
Комментарий: рекомендую, недорого и по качеству не уступает импортным аналогам
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