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Описание

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Эменд капс./комплект капс. капс., 125 мг, 80 мг, 3 шт.

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5.0
(2)
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Коротко о товаре

Артикул Маркета
3123913801
Тип препарата
Назначение
Действующее вещество
Форма выпуска
капсулы
Инструкция
{"widgets":{"@card/SpecsList":{"/content/page/fancyPage/productSpecsList":{"wrapperProps":{"margins":{"top":4,"bottom":4}},"specsLimit":5,"title":"Коротко о товаре","titleSize":"14","type":"minimal","offset":"s","isHealthCategory":true,"forceShowWidget":true,"withFridge":true}}},"meta":{"/content/page/fancyPage/productSpecsList":{"name":"@card/SpecsList"}},"collections":{"minimalSpecs":{"10138614295837328619":{"specItems":[{"name":"Артикул Маркета","value":"3123913801","withCopyValueButton":true},{"name":"тип препарата","value":"рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"назначение","value":"рвота","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["36476390:36617844"]}}},{"name":"действующее вещество","value":"Апрепитант","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["27144131:28710292"]}}},{"name":"форма выпуска","value":"капсулы"},{"name":"страна-производитель","value":"США"}]}},"compactSpecs":{"10138614295837328619":{"specItems":[{"name":"Артикул Маркета","value":"3123913801","withCopyValueButton":true},{"name":"Тип препарата","value":"Рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"Назначение","value":"Рвота","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["36476390:36617844"]}}},{"name":"Действующее вещество","value":"Апрепитант","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["27144131:28710292"]}}},{"name":"Форма выпуска","value":"Капсулы"}]}},"fullSpecs":{"10138614295837328619":{"specItems":[{"name":"Тип препарата","value":"лекарственный препарат","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["34324371:35649313"]}}},{"name":"Рецептурный препарат","value":"да","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["27272850:1,0"]}}},{"name":"Органы и системы","value":"пищеварительная система","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["34045610:34516020"]}}},{"name":"Назначение","value":"рвота","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["36476390:36617844"]}}},{"name":"Показания к применению","value":"Предупреждение острой и отсроченной тошноты и рвоты, вызываемые высоко- или умеренноэметогенными противоопухолевыми препаратами (в комбинации с другими противорвотными препаратами)."},{"name":"Противопоказания","value":"Тяжелая печеночная недостаточность (\u003E9 баллов по шкале Чайлд-Пью).\u003Cbr\u003EОдновременное применение с пимозидом, терфенадином, астемизолом и цизапридом.\u003Cbr\u003EПовышенная чувствительность к апрепитанту или другим компонентам препарата."},{"name":"Состав","value":"Действующее вещество: апрепитант – 80 мг.\u003Cbr\u003EВспомогательные вещества: гидроксипропилцеллюлоза - 16 мг, натрия лаурилсульфат - 0.3097 мг, сахароза - 80 мг, целлюлоза микрокристаллическая (в гранулах) - 39.16 мг, натрия лаурилсульфат (микронизированный) - 0.3097 мг.\u003Cbr\u003EСостав твердой желатиновой капсулы: титана диоксид - 1.0434 мг, желатин - до 58 мг.\u003Cbr\u003EЧернила черные SW-9008/9009."},{"name":"Действующее вещество","value":"Апрепитант","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["27144131:28710292"]}}},{"name":"Способ применения и дозы","value":"Внутрь независимо от приема пищи в течение 3 дней в комбинации с ГКС и антагонистами серотониновых 5-HT3-рецепторов. Рекомендуемая доза составляет 125 мг за 1 ч до приема химиотерапевтических препаратов в 1 день и 80 мг 1 раз/сут утром во 2 и 3 дни."},{"name":"Побочные действия","value":"1.Со стороны системы кроветворения: анемия, фебрильная нейтропения.2.Со стороны ЦНС: головная боль, головокружение,патологические сновидения, когнитивные нарушения, дезориентация, эйфория, тревожность.3.Со стороны органов чувств: конъюнктивит, шум в ушах.4.Со стороны сердечно-сосудистой системы: брадикардия.5.Со стороны дыхательной системы: фарингит, чиханье, кашель, постназальный синдром, раздражение глотки.6.Со стороны пищеварительной системы: анорексия, икота, запор, диарея, диспепсия, отрыжка,тошнота, кислотный рефлюкс, извращение вкуса, дискомфорт в эпигастрии, стойкий запор, гастроэзофагеальный рефлюкс, перфоративная язва двенадцатиперстной кишки, боли в животе, сухость во рту, энтероколит, вздутие живота, стоматит.7.Дерматологические реакции: сыпь, акне, фотосенсибилизация, повышенная потливость, жирная кожа, зуд.8.Со стороны костно-мышечной системы: мышечные спазмы, миалгия.9.Со стороны мочевыделительной системы: полиурия, дизурия, поллакиурия.10.Со стороны лабораторных показателей: повышение содержания АЛТ и АСТ,повышение активности щелочной фосфатазы, гипергликемия, гипонатриемия, микрогематурия.11.Аллергические реакции: в 1 случае при применении апрепитанта на фоне химиотерапии отмечен синдром Стивенса-Джонсона и еще в 1 случае при применении только апрепитанта наблюдался ангионевротический отек и крапивница.12.Прочие: слабость,повышенная утомляемость,отеки, приступообразные ощущения жара (приливы), ощущение дискомфорта в области грудной клетки, сонливость, жажда, снижение или повышение массы тела, присоединение стафилококковой или грибковой (кандидоз) инфекции."},{"name":"Фармакологическое действие","value":"Противорвотное.Антагонист NK1-рецепторов предупреждает развитие рвоты, вызванной химиотерапевтическими препаратами, (например, цисплатином) за счет центрального механизма действия."},{"name":"Фармакологическая группа","value":"противорвотные средства"},{"name":"Форма выпуска","value":"капсулы"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["35947170:36763744"]}}},{"name":"Условия хранения","value":"Препарат следует хранить в недоступном для детей месте при температуре не выше 30°С. Срок годности - 4 года."},{"name":"Передозировка","value":"Симптомы: у принявших 1440 мг апрепитанта, наблюдались сонливость и головная боль.\u003Cbr\u003EЛечение: терапию следует прекратить и обеспечить контроль состояния пациента. При необходимости проводят симптоматическую терапию. В связи с противорвотным действием апрепитанта лекарственные препараты, вызывающие рвоту, скорее всего не будут эффективны. Антидот к препарату неизвестен. Гемодиализ не эффективен."},{"name":"Применение при беременности и кормлении грудью","value":"Хорошо контролируемых исследований у беременных женщин не проводилось. ЭМЕНД при беременности применять не рекомендуется.\u003Cbr\u003EПРИМЕНЕНИЕ В ПЕРИОД КОРМЛЕНИЯ ГРУДЬЮ\u003Cbr\u003EНесмотря на то, что данных о выделении апрепитанта в грудное молоко у кормящих женщин нет, следует принять решение о прекращении кормления или отмене препарата в связи с возможным нежелательным действием ЭМЕНДА на грудных детей."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Исследований по изучению влияния препарата Эменд на способность управлять транспортными средствами или работать с механизмами не проводилось. Однако следует учитывать профиль побочных действий препарата, которые могут повлиять на способность пациентов управлять механизмами. У пациентов возможны различные реакции на препарат Эменд."},{"name":"Особые указания","value":"Во время лечения и в течение 1 месяца после приема последней дозы следует использовать альтернативные и резервные методы контрацепции."},{"name":"Взаимодействие","value":"Апрепитант является субстратом. умеренным ингибитором и индуктором изофермента CYP3A4. Апрепитант также является индуктором изофермента CYP2C9.\u003Cbr\u003EПри одновременном назначении апрепитант может повышать концентрацию в плазме лекарственных препаратов, метаболизм которых происходит под действием изофермента CYP3A4. Препарат Эменд не следует применять одновременно с пимозидом, терфенадином, астемизолом, цизапридом или производными алкалоидов спорыньи. Ингибирование изофермента CYP3A4 апрепитантом может привести к повышению концентрации этих препаратов в плазме и к потенциально серьезным и опасным для жизни явлениям.\u003Cbr\u003EАпрепитант индуцирует метаболизм варфарина и толбутамида. Одновременное назначение препарата Эменд с этими или другими препаратами, которые метаболизируются изоферментом CYP2C9 (например, фенитоин), может привести к снижению их концентрации в плазме. Не отмечено влияния препарата Эменд на площадь под кривой \"концентрация - время\" R (+)- или S (-)-варфарина, однако при совместном применении наблюдалось снижение минимальной концентрации S (-)- варфарина, которое сопровождалось снижением МНО на 14% через 5 дней после окончания приема препарата Эменд. У пациентов, получающих терапию варфарином в течение длительного периода времени, следует тщательно мониторировать уровень МНО в течение 2 недель, и особенно на 7-10 дни после начала приема препарата Эменд по 3-дневной схеме, во время каждого цикла химиотерапии. Препарат Эменд уменьшает площадь под кривой \"концентрация - время\" толбутамида, являющегося субстратом изофермента CYP2C9, на 23% в 4 день, на 28% в 8 день и на 15% в 15 день. При этом толбутамид в однократной дозе 500 мг принимался перед началом 3-дневной схемы терапии препаратом Эменд в день 4, 8 и 15. Взаимодействие препарата Эменд с препаратами, являющимися субстратами переносчика Р-гликопротеина, маловероятно вследствие отсутствия взаимодействия препарата Эменд с дигоксином.\u003Cbr\u003EАпрепитант не оказывает клинически значимого влияния на фармакокинетику антагонистов 5-НТ3- рецепторов: ондансетрона, гранисетрона и гидродоласетрона (активного метаболита доласетрона).\u003Cbr\u003EПри одновременном приеме препарата Эменд и глюкокортикостероидов отмечено увеличение площади под кривой \"концентрация - время\" для дексаметазона, принимаемого внутрь, в 2,2 раза, для метилпреднизолона, вводимого внутривенно, в 1,3 раза и метилпреднизолона, принимаемого внутрь, в 2,5 раза. В связи с этим для достижения необходимого эффекта стандартную дозу дексаметазона при применении его внутрь в комбинации с апрепитантом снижают на 50%, дозу метилпреднизолона при введении внутривенно снижают приблизительно на 25%, при назначении внутрь - на 50%.\u003Cbr\u003EПри применении препарата Эменд вместе с химиотерапевтическими препаратами, метаболизм которых главным образом или частично происходит при участии изофермента CYP3A4 (этопозид, винорелбин, доцетаксел, ифосфамид, циклофосфамид, иринотекан и паклитаксел), дозы этих препаратов можно не корректировать. Однако рекомендуется соблюдать осторожность в отношении пациентов, получающих данные препараты, и вести за ними дополнительное наблюдение. В пострегистрационных исследованиях были зафиксированы случаи нейротоксичности, которые могут рассматриваться как возможное побочное действие ифосфамида, применяемого совместно с апрепитантом.\u003Cbr\u003EВлияния препарата Эменд на фармакокинетику доцетаксела не выявлено. Эффективность гормональных контрацептивов в период приема и в течение 28 дней после окончания приема препарата Эменд может быть снижена. Во время лечения препаратом Эменд и в течение 1 месяца после приема последней дозы препарата Эменд следует применять альтернативные или резервные методы контрацепции.\u003Cbr\u003EПри одновременном пероральном приеме мидазолама и препарата Эменд отмечено увеличение площади под кривой \"концентрация - время\" мидазолама. Потенциальный эффект повышения концентрации в плазме мидазолама или других бензодиазепинов, метаболизм которых осуществляется через изофермент CYP3A4 (алпразолам, триазолам), следует принимать во внимание при одновременном назначении этих препаратов с препаратом Эменд.\u003Cbr\u003EОдновременный прием препарата Эменд с препаратами, которые ингибируют активность изофермента CYP3A4, может привести к увеличению концентрации апрепитанта в плазме. Следовательно необходимо с осторожностью назначать препарат Эменд в комбинации с сильными ингибиторами изофермента CYP3A4 (например, кетоконазолом). Однако одновременный прием препарата Эменд с умеренными ингибиторами изофермента CYP3A4 (например, дилтиаземом, итраконазолом, вориконазолом, позаконазолом, кларитромицином, телитромицином и ингибиторами протеазы) не вызывает клинически значимых изменений концентрации апрепитанта в плазме.\u003Cbr\u003EОдновременный прием препарата Эменд с препаратами, которые являются сильными индукторами изофермента CYP3A4 (например, рифампицином, фенитоином, карбамазепином, фенобарбиталом), может привести к уменьшению концентрации апрепитанта в плазме и, таким образом, к снижению эффективности препарата Эменд. Также одновременное применение апрепитанта с препаратами зверобоя продырявленного не рекомендуется.\u003Cbr\u003EУ пациентов с легкой и умеренной гипертензией прием таблетки апрепитанта. содержащей дозу, сопоставимую с 230 мг препарата в капсулах, в комбинации с дилтиаземом в дозе 120 мг 3 раза в день в течение 5 дней приводил к увеличению площади под кривой \"концентрация - время\" апрепитанта в 2 раза и одновременному увеличению площади под кривой \"концентрация - время\" дилтиазема в 1,7 раза. Эти фармакокинетические эффекты не приводили к клинически значимым изменениям ЭКГ, частоты сердечных сокращений или артериального давления по сравнению с изменениями данных показателей при приеме только дилтиазема.\u003Cbr\u003EОдновременный прием апрепитанта 1 раз в сутки в форме таблетки в дозе, сопоставимой с 85 мг или 170 мг препарата в капсулах, и пароксетина в дозе 20 мг раз в день приводил к уменьшению площади под кривой \"концентрация - время\" приблизительно на 25% и Сmах приблизительно на 20% как для апрепитанта, так и для пароксетина."},{"name":"Регистрационный номер","value":"ЛС-000587"},{"name":"Дата государственной регистрации","value":"22.06.2017"},{"name":"Владелец регистрационного удостоверения","value":"АКРИХИН","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["34324371:35649313","7893318:11037214"]}}},{"name":"Страна бренда","value":"Нидерланды"},{"name":"Страна-производитель","value":"США"},{"name":"Название препарата","value":"Эменд","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["17796364:17852939"]}}},{"name":"Срок годности","value":"757 дн."}]}},"fullSpecsGrouped":{"10138614295837328619":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"пищеварительная система"},{"name":"Назначение","value":"рвота"},{"name":"Показания к применению","value":"Предупреждение острой и отсроченной тошноты и рвоты, вызываемые высоко- или умеренноэметогенными противоопухолевыми препаратами (в комбинации с другими противорвотными препаратами)."},{"name":"Противопоказания","value":"Тяжелая печеночная недостаточность (\u003E9 баллов по шкале Чайлд-Пью).\u003Cbr\u003EОдновременное применение с пимозидом, терфенадином, астемизолом и цизапридом.\u003Cbr\u003EПовышенная чувствительность к апрепитанту или другим компонентам препарата."},{"name":"Состав","value":"Действующее вещество: апрепитант – 80 мг.\u003Cbr\u003EВспомогательные вещества: гидроксипропилцеллюлоза - 16 мг, натрия лаурилсульфат - 0.3097 мг, сахароза - 80 мг, целлюлоза микрокристаллическая (в гранулах) - 39.16 мг, натрия лаурилсульфат (микронизированный) - 0.3097 мг.\u003Cbr\u003EСостав твердой желатиновой капсулы: титана диоксид - 1.0434 мг, желатин - до 58 мг.\u003Cbr\u003EЧернила черные SW-9008/9009."},{"name":"Действующее вещество","value":"Апрепитант"},{"name":"Способ применения и дозы","value":"Внутрь независимо от приема пищи в течение 3 дней в комбинации с ГКС и антагонистами серотониновых 5-HT3-рецепторов. Рекомендуемая доза составляет 125 мг за 1 ч до приема химиотерапевтических препаратов в 1 день и 80 мг 1 раз/сут утром во 2 и 3 дни."},{"name":"Побочные действия","value":"1.Со стороны системы кроветворения: анемия, фебрильная нейтропения.2.Со стороны ЦНС: головная боль, головокружение,патологические сновидения, когнитивные нарушения, дезориентация, эйфория, тревожность.3.Со стороны органов чувств: конъюнктивит, шум в ушах.4.Со стороны сердечно-сосудистой системы: брадикардия.5.Со стороны дыхательной системы: фарингит, чиханье, кашель, постназальный синдром, раздражение глотки.6.Со стороны пищеварительной системы: анорексия, икота, запор, диарея, диспепсия, отрыжка,тошнота, кислотный рефлюкс, извращение вкуса, дискомфорт в эпигастрии, стойкий запор, гастроэзофагеальный рефлюкс, перфоративная язва двенадцатиперстной кишки, боли в животе, сухость во рту, энтероколит, вздутие живота, стоматит.7.Дерматологические реакции: сыпь, акне, фотосенсибилизация, повышенная потливость, жирная кожа, зуд.8.Со стороны костно-мышечной системы: мышечные спазмы, миалгия.9.Со стороны мочевыделительной системы: полиурия, дизурия, поллакиурия.10.Со стороны лабораторных показателей: повышение содержания АЛТ и АСТ,повышение активности щелочной фосфатазы, гипергликемия, гипонатриемия, микрогематурия.11.Аллергические реакции: в 1 случае при применении апрепитанта на фоне химиотерапии отмечен синдром Стивенса-Джонсона и еще в 1 случае при применении только апрепитанта наблюдался ангионевротический отек и крапивница.12.Прочие: слабость,повышенная утомляемость,отеки, приступообразные ощущения жара (приливы), ощущение дискомфорта в области грудной клетки, сонливость, жажда, снижение или повышение массы тела, присоединение стафилококковой или грибковой (кандидоз) инфекции."},{"name":"Фармакологическое действие","value":"Противорвотное.Антагонист NK1-рецепторов предупреждает развитие рвоты, вызванной химиотерапевтическими препаратами, (например, цисплатином) за счет центрального механизма действия."},{"name":"Фармакологическая группа","value":"противорвотные средства"},{"name":"Форма выпуска","value":"капсулы"},{"name":"Способ применения/введения","value":"пероральный"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Препарат следует хранить в недоступном для детей месте при температуре не выше 30°С. Срок годности - 4 года."},{"name":"Передозировка","value":"Симптомы: у принявших 1440 мг апрепитанта, наблюдались сонливость и головная боль.\u003Cbr\u003EЛечение: терапию следует прекратить и обеспечить контроль состояния пациента. При необходимости проводят симптоматическую терапию. В связи с противорвотным действием апрепитанта лекарственные препараты, вызывающие рвоту, скорее всего не будут эффективны. Антидот к препарату неизвестен. Гемодиализ не эффективен."},{"name":"Применение при беременности и кормлении грудью","value":"Хорошо контролируемых исследований у беременных женщин не проводилось. ЭМЕНД при беременности применять не рекомендуется.\u003Cbr\u003EПРИМЕНЕНИЕ В ПЕРИОД КОРМЛЕНИЯ ГРУДЬЮ\u003Cbr\u003EНесмотря на то, что данных о выделении апрепитанта в грудное молоко у кормящих женщин нет, следует принять решение о прекращении кормления или отмене препарата в связи с возможным нежелательным действием ЭМЕНДА на грудных детей."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Исследований по изучению влияния препарата Эменд на способность управлять транспортными средствами или работать с механизмами не проводилось. Однако следует учитывать профиль побочных действий препарата, которые могут повлиять на способность пациентов управлять механизмами. У пациентов возможны различные реакции на препарат Эменд."},{"name":"Особые указания","value":"Во время лечения и в течение 1 месяца после приема последней дозы следует использовать альтернативные и резервные методы контрацепции."},{"name":"Взаимодействие","value":"Апрепитант является субстратом. умеренным ингибитором и индуктором изофермента CYP3A4. Апрепитант также является индуктором изофермента CYP2C9.\u003Cbr\u003EПри одновременном назначении апрепитант может повышать концентрацию в плазме лекарственных препаратов, метаболизм которых происходит под действием изофермента CYP3A4. Препарат Эменд не следует применять одновременно с пимозидом, терфенадином, астемизолом, цизапридом или производными алкалоидов спорыньи. Ингибирование изофермента CYP3A4 апрепитантом может привести к повышению концентрации этих препаратов в плазме и к потенциально серьезным и опасным для жизни явлениям.\u003Cbr\u003EАпрепитант индуцирует метаболизм варфарина и толбутамида. Одновременное назначение препарата Эменд с этими или другими препаратами, которые метаболизируются изоферментом CYP2C9 (например, фенитоин), может привести к снижению их концентрации в плазме. Не отмечено влияния препарата Эменд на площадь под кривой \"концентрация - время\" R (+)- или S (-)-варфарина, однако при совместном применении наблюдалось снижение минимальной концентрации S (-)- варфарина, которое сопровождалось снижением МНО на 14% через 5 дней после окончания приема препарата Эменд. У пациентов, получающих терапию варфарином в течение длительного периода времени, следует тщательно мониторировать уровень МНО в течение 2 недель, и особенно на 7-10 дни после начала приема препарата Эменд по 3-дневной схеме, во время каждого цикла химиотерапии. Препарат Эменд уменьшает площадь под кривой \"концентрация - время\" толбутамида, являющегося субстратом изофермента CYP2C9, на 23% в 4 день, на 28% в 8 день и на 15% в 15 день. При этом толбутамид в однократной дозе 500 мг принимался перед началом 3-дневной схемы терапии препаратом Эменд в день 4, 8 и 15. Взаимодействие препарата Эменд с препаратами, являющимися субстратами переносчика Р-гликопротеина, маловероятно вследствие отсутствия взаимодействия препарата Эменд с дигоксином.\u003Cbr\u003EАпрепитант не оказывает клинически значимого влияния на фармакокинетику антагонистов 5-НТ3- рецепторов: ондансетрона, гранисетрона и гидродоласетрона (активного метаболита доласетрона).\u003Cbr\u003EПри одновременном приеме препарата Эменд и глюкокортикостероидов отмечено увеличение площади под кривой \"концентрация - время\" для дексаметазона, принимаемого внутрь, в 2,2 раза, для метилпреднизолона, вводимого внутривенно, в 1,3 раза и метилпреднизолона, принимаемого внутрь, в 2,5 раза. В связи с этим для достижения необходимого эффекта стандартную дозу дексаметазона при применении его внутрь в комбинации с апрепитантом снижают на 50%, дозу метилпреднизолона при введении внутривенно снижают приблизительно на 25%, при назначении внутрь - на 50%.\u003Cbr\u003EПри применении препарата Эменд вместе с химиотерапевтическими препаратами, метаболизм которых главным образом или частично происходит при участии изофермента CYP3A4 (этопозид, винорелбин, доцетаксел, ифосфамид, циклофосфамид, иринотекан и паклитаксел), дозы этих препаратов можно не корректировать. Однако рекомендуется соблюдать осторожность в отношении пациентов, получающих данные препараты, и вести за ними дополнительное наблюдение. В пострегистрационных исследованиях были зафиксированы случаи нейротоксичности, которые могут рассматриваться как возможное побочное действие ифосфамида, применяемого совместно с апрепитантом.\u003Cbr\u003EВлияния препарата Эменд на фармакокинетику доцетаксела не выявлено. Эффективность гормональных контрацептивов в период приема и в течение 28 дней после окончания приема препарата Эменд может быть снижена. Во время лечения препаратом Эменд и в течение 1 месяца после приема последней дозы препарата Эменд следует применять альтернативные или резервные методы контрацепции.\u003Cbr\u003EПри одновременном пероральном приеме мидазолама и препарата Эменд отмечено увеличение площади под кривой \"концентрация - время\" мидазолама. Потенциальный эффект повышения концентрации в плазме мидазолама или других бензодиазепинов, метаболизм которых осуществляется через изофермент CYP3A4 (алпразолам, триазолам), следует принимать во внимание при одновременном назначении этих препаратов с препаратом Эменд.\u003Cbr\u003EОдновременный прием препарата Эменд с препаратами, которые ингибируют активность изофермента CYP3A4, может привести к увеличению концентрации апрепитанта в плазме. Следовательно необходимо с осторожностью назначать препарат Эменд в комбинации с сильными ингибиторами изофермента CYP3A4 (например, кетоконазолом). Однако одновременный прием препарата Эменд с умеренными ингибиторами изофермента CYP3A4 (например, дилтиаземом, итраконазолом, вориконазолом, позаконазолом, кларитромицином, телитромицином и ингибиторами протеазы) не вызывает клинически значимых изменений концентрации апрепитанта в плазме.\u003Cbr\u003EОдновременный прием препарата Эменд с препаратами, которые являются сильными индукторами изофермента CYP3A4 (например, рифампицином, фенитоином, карбамазепином, фенобарбиталом), может привести к уменьшению концентрации апрепитанта в плазме и, таким образом, к снижению эффективности препарата Эменд. Также одновременное применение апрепитанта с препаратами зверобоя продырявленного не рекомендуется.\u003Cbr\u003EУ пациентов с легкой и умеренной гипертензией прием таблетки апрепитанта. содержащей дозу, сопоставимую с 230 мг препарата в капсулах, в комбинации с дилтиаземом в дозе 120 мг 3 раза в день в течение 5 дней приводил к увеличению площади под кривой \"концентрация - время\" апрепитанта в 2 раза и одновременному увеличению площади под кривой \"концентрация - время\" дилтиазема в 1,7 раза. Эти фармакокинетические эффекты не приводили к клинически значимым изменениям ЭКГ, частоты сердечных сокращений или артериального давления по сравнению с изменениями данных показателей при приеме только дилтиазема.\u003Cbr\u003EОдновременный прием апрепитанта 1 раз в сутки в форме таблетки в дозе, сопоставимой с 85 мг или 170 мг препарата в капсулах, и пароксетина в дозе 20 мг раз в день приводил к уменьшению площади под кривой \"концентрация - время\" приблизительно на 25% и Сmах приблизительно на 20% как для апрепитанта, так и для пароксетина."},{"name":"Регистрационный номер","value":"ЛС-000587"},{"name":"Дата государственной регистрации","value":"22.06.2017"},{"name":"Владелец регистрационного удостоверения","value":"АКРИХИН"},{"name":"Страна бренда","value":"Нидерланды"},{"name":"Страна-производитель","value":"США"},{"name":"Название препарата","value":"Эменд"},{"name":"Срок годности","value":"757 дн."}]}],"transitionId":"tr_4639617134359543204"}}}}
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    Цена 4 536 ₽
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  • Ондансетрон р-р для в/в введ. и в/м введ., 2 мг/мл, 2 мл, 5 шт.
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    Ондансетрон р-р для в/в введ. и в/м введ., 2 мг/мл, 2 мл, 5 шт.

    Рейтинг товара: 5 из 5
    на основе 20 оценок
    Цена 169 ₽
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  • Ондансетрон-Тева таб. п/о плен., 8 мг, 10 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-3341xux5jb5/toggleWishlist":{"skuId":"228007920","productId":1778171092,"offerId":"sao5glFjXZdZWsy69aMj0Q","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ/IjOoMLDjIIkEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI1PnyzwYQ8L/cbBjW/Y0HINrZwQc=","sign":"OlGfoHMVTwREIdGrpBaB0ho3+AYL4/EQDXBYUYWbZ5s="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-3341xux5jb5/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Ондансетрон-Тева таб. п/о плен., 8 мг, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 568 ₽
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  • Латран р-р для в/в и в/м введ. амп., 2 мг/мл, 2 мл, 5 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-j7tvcxvwhr8/toggleWishlist":{"skuId":"265146241","productId":1400799625,"offerId":"zPqeQ77eMVldpUsxgg_sFQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ/IjOoMLDjIIkEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIiYP6mwUQgZ+3fhir3tAHINrZwQc=","sign":"9sui2UTNAZ8kUSnSVe2PQVYKyPb4rJ0Ul24DJKAvISY="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-j7tvcxvwhr8/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Латран р-р для в/в и в/м введ. амп., 2 мг/мл, 2 мл, 5 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 156 ₽
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  • Месакол таб. п/о кш/раств., 400 мг, 50 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-hjjtqci84he/toggleWishlist":{"skuId":"186858002","productId":1780857157,"offerId":"llAjnUeCv4hR3aO3W-x-Mw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ/IjOoMLDjIIkEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIxfKW0QYQkvSMWRib1c8GINrZwQc=","sign":"IiCDnd9XRJd/R03Ocu9GD1uYFh/87bx6W8dLuGn9dOA="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-hjjtqci84he/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Месакол таб. п/о кш/раств., 400 мг, 50 шт.

    Рейтинг товара: 4.9 из 5
    на основе 8 оценок
    Цена 736 ₽
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  • Гепатрин капс., 44 г, 30 шт., 1 уп.
    –10 %
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    Гепатрин капс., 44 г, 30 шт., 1 уп.

    Рейтинг товара: 4.8 из 5
    на основе 870 оценок
    Цена 459 ₽ вместо 510
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  • Хайрабезол таб. п/о плен. кш/раств., 10 мг, 15 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-cl6mod1uz9h/toggleWishlist":{"skuId":"186887776","productId":1400799474,"offerId":"4F3UL8NyggHbG_roAsxAKQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ/IjOoMLDjIIkEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI8oH6mwUQ4NyOWRjF5dAHINrZwQc=","sign":"jxXvbObi0JMCGhmYmqQYm82ENvv+YhKsOaeZABKZU9k="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-cl6mod1uz9h/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Хайрабезол таб. п/о плен. кш/раств., 10 мг, 15 шт.

    Рейтинг товара: 5 из 5
    на основе 8 оценок
    Цена 409 ₽
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  • Метоклопрамид таб., 10 мг, 56 шт.
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    Метоклопрамид таб., 10 мг, 56 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 56 ₽
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  • Гептрал лиоф. д/приг. р-ра для в/в и в/м введ. фл. + р-ль в амп., 400 мг, 5 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-fom73p7y2ub/toggleWishlist":{"skuId":"649939052","productId":1781572737,"offerId":"2UiWNa85HphXWa-x1KcdqA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ/IjOoMLDjIIkEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIgcnC0QYQ7JD1tQIY0MTeByDa2cEH","sign":"2fbzGSKdLw8PvyEfwRImghZ75RDWhcKfdrcmbnOWdsk="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-fom73p7y2ub/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Гептрал лиоф. д/приг. р-ра для в/в и в/м введ. фл. + р-ль в амп., 400 мг, 5 шт.

    Рейтинг товара: 4.9 из 5
    на основе 55 оценок
    Цена 1 938 ₽
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  • Разо таб. п/о кш/раств., 20 мг, 30 шт.
    –13 %
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    Разо таб. п/о кш/раств., 20 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 25 оценок
    Цена 556 ₽ вместо 639
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  • Даларгин-Эллара лиоф. д/приг. р-ра д/в-в и в/м введ. амп., 1 мг, 10 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ydvwrghmgm/toggleWishlist":{"skuId":"101796226728","productId":649990006,"offerId":"E_kltT9e_ph3chPqlKCN8g","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ/IjOoMLDjIIkEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI9p74tQIQqM2cnPsCGPrc0Acg2tnBBw==","sign":"2OKFv5XzF80Os2WcJKohzDkinQsaAKpm56U4rqYE/Rc="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ydvwrghmgm/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Даларгин-Эллара лиоф. д/приг. р-ра д/в-в и в/м введ. амп., 1 мг, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 1 126 ₽
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Инструкция

Показания к применению

Предупреждение острой и отсроченной тошноты и рвоты, вызываемые высоко- или умеренноэметогенными противоопухолевыми препаратами (в комбинации с другими противорвотными препаратами).

Противопоказания

Тяжелая печеночная недостаточность (>9 баллов по шкале Чайлд-Пью).
Одновременное применение с пимозидом, терфенадином, астемизолом и цизапридом.
Повышенная чувствительность к апрепитанту или другим компонентам препарата.

Способ применения и дозы

Внутрь независимо от приема пищи в течение 3 дней в комбинации с ГКС и антагонистами серотониновых 5-HT3-рецепторов. Рекомендуемая доза составляет 125 мг за 1 ч до приема химиотерапевтических препаратов в 1 день и 80 мг 1 раз/сут утром во 2 и 3 дни.
Полная инструкция
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Эменд капс./комплект капс. капс.
Эменд капс./комплект капс. капс., 125 мг, 80 мг, 3 шт.
5.0
(2)
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Задать вопрос
Инструкция

7 047 ₽

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5.0
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У продавца:2 оценки·1 отзыв
У всех продавцов:26 оценок·7 отзывов
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5 месяцев назад • Юлия Барабанова • Куплен на Маркете
Достоинства: работает
Недостатки: очень дорого
Посмотреть все отзывы на Маркете
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