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Описание

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Цетротид лиоф д/приг. р-ра п/к введ. фл., 7 шт.

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У продавца: 
нет • На Маркете: 3.8
(5)
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Коротко о товаре

Артикул Маркета
4461925324
Тип препарата
Назначение
Действующее вещество
Форма выпуска
лиофилизат для приготовления раствора для инъекций
Инструкция
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Для достижения максимальной эффективности лечения препаратом Цетротид следует внимательно ознакомиться с данными рекомендациями.\u003Cbr\u003EПосле первой инъекции пациентка 30 минут должна находиться под наблюдением врача, чтобы удостовериться в отсутствии аллергической или псевдоаллергической реакции на введение препарата. Все инструменты и препараты для купирования такой реакции должны быть в наличии.\u003Cbr\u003EЦетротид 0,25 мг\u003Cbr\u003EСодержимое 1 флакона (0,25 мг цетрореликса) следует вводить один раз в день через каждые 24 ч утром или вечером.\u003Cbr\u003EВведение препарата утром: лечение Цетротидом следует начинать на 5 или 6 день стимуляции яичников (приблизительно через 96-120 ч после начала стимуляции) препаратом гонадотропина, рекомбинантным или выделенным из мочи, и продолжать в течение всего периода стимуляции гонадотропином, включая день введения овуляторной дозы хорионического гонадотропина (ХГ).\u003Cbr\u003EВведение препарата вечером: лечение Цетротидом следует начинать на 5 день стимуляции яичников (приблизительно через 96-108 ч после начала стимуляции) препаратом гонадотропина, рекомбинантным или выделенным из мочи, и продолжать в течение всего периода стимуляции гонадотропином, включая вечер, предшествующий дню введения овуляторной дозы ХГ.\u003Cbr\u003EЦетротид 3,0 мг\u003Cbr\u003EСодержимое 1 флакона (3,0 мг цетрореликса) следует вводить на 7-й день стимуляции яичников (приблизительно через 132-144 ч после начала стимуляции) препаратом гонадотропина, рекомбинантным или выделенным из мочи.\u003Cbr\u003EПосле однократного введения 3,0 мг цетрореликса действие препарата продолжается в течение не менее 4 дней. Если на 5 день после введения Цетротида 3,0 мг размеры фолликулов не позволяют назначить индукцию овуляции, следует дополнительно ввести 0,25 мг цетрореликса (Цетротид 0,25 мг) один раз в сутки, начиная через 96 ч после введения препарата Цетротид 3,0 мг и включая день введения овуляторной дозы ХГ.\u003Cbr\u003EРекомендации по самостоятельному введению препарата Цетротид 0,25 мг и 3,0 мг (информация для пациента).\u003Cbr\u003EПервая инъекция должна быть сделана врачом-специалистом. После получения соответствующих инструкций врача о симптомах, которые могут свидетельствовать о возникновении аллергической реакции, о последствиях такой реакции и о необходимости ее лечения, пациентка может самостоятельно вводить Цетротид.\u003Cbr\u003EЦетротид вводят подкожно в нижнюю часть передней брюшной стенки, желательно в область вокруг пупка. Во избежание появления местного раздражения при повторном введении препарата, место инъекции следует ежедневно менять.\u003Cbr\u003EЦетротид следует разводить только в прилагаемом растворителе. Во время растворения флакон следует осторожно покачивать. Во избежание образования пузырьков, не следует применять энергичное встряхивание для ускорения растворения. Нельзя использовать раствор, если он непрозрачен или содержит нерастворенные частицы.\u003Cbr\u003EИз флакона следует набирать в шприц все его содержимое. Это позволит ввести дозу цетрореликса не менее 0,23 мг при использовании препарата Цетротид 0,25 мг и не менее 2,82 мг при использовании препарата Цетротид 3,0 мг. Раствор следует вводить сразу после его приготовления."},{"name":"Побочные действия","value":"Наиболее часто отмечались реакции в месте введения, такие как покраснение, зуд и припухлость, как правило, слабо выраженные и проходящие. В клинических исследованиях данные явления отмечались с частотой 9,4% после многократных инъекций Цетротида в дозе 0,25 мг.\u003Cbr\u003EПри процедуре стимуляции овуляции гонадотропинами относительно часто отмечался синдром гиперстимуляции яичников (СГЯ) от слабой до умеренной степени выраженности (I-II степени по классификации ВОЗ). На его появление могут указывать такие симптомы, как ощущение напряжения и боль в животе, тошнота, рвота, диарея, увеличение массы тела, увеличение яичников (см. раздел \"Особые указания\"). С другой стороны, тяжелый СГЯ (III ст. - по классификации ВОЗ) отмечался нечасто (к перечисленным симптомам СГЯ могут добавляться одышка, асцит, гиповолемия,\u003Cbr\u003Eгемоконцентрация, нарушение электролитного баланса, плевральный выпот, накопление\u003Cbr\u003Eжидкости в перикардиальной полости, олигурия, острый респираторный дистресс-синдром и тромбоэмболические нарушения).\u003Cbr\u003EРеакции гиперчувствительности, включая псевдоаллергические/анафилактоидные реакции (схожие по симптомам с аллергическими, но без выработки антител, и, как правило, проявляющиеся в той или иной степени в виде покраснения кожи, чувства жара, крапивницы, головной боли, затруднения дыхания) отмечались нечасто.\u003Cbr\u003EНиже представлены данные обо всех нежелательных реакциях, наблюдавшихся при применении Цетротида, в соответствии с общепринятой системно-органной классификацией, которые в зависимости от частоты возникновения подразделяются на очень частые (\u003E1/10 случаев применения), частые (\u003E1/100 и \u003C1/10), нечастые (\u003E1/1000 и \u003C1/100), редкие (\u003E1/10000 и \u003C1/1000) и очень редкие (\u003C1/10000).\u003Cbr\u003EНарушения со стороны иммунной системы\u003Cbr\u003EНечасто: системная аллергическая или псевдоаллергическая реакция, включая жизнеугрожающую анафилаксию.\u003Cbr\u003EНарушения со стороны нервной системы\u003Cbr\u003EНечасто: головная боль.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта\u003Cbr\u003EНечасто: тошнота.\u003Cbr\u003EНарушения со стороны половых органов и молочной железы\u003Cbr\u003EЧасто: легкий или умеренный СГЯ (I-II ст. по классификации ВОЗ);\u003Cbr\u003EНечасто: тяжелый СГЯ (III ст. по классификации ВОЗ).\u003Cbr\u003E\n\u003Cbr\u003EОбщие расстройства и нарушения в месте введения\u003Cbr\u003EЧасто: реакции в месте введения (покраснение, припухлость, зуд), как правило, преходящие и слабо выраженные."},{"name":"Фармакологическое действие","value":"Цетрореликс, являясь аналогом гонадотропин-рилизинг гормона (ГнРГ), связывается с рецепторами мембран клеток гипофиза и конкурентно тормозит связывание эндогенного ГнРГ этими рецепторами. Цетрореликс дозозависимо тормозит секрецию гонадотропинов гипофизом - лютеинизирующего (ЛГ) и фолликулостимулирующего (ФСГ) гормонов. В условиях отсутствия предварительной стимуляции начало угнетения секреторной функции гипофиза наступает фактически сразу после введения препарата продолжительность действия цетрореликса зависит от вводимой дозы. У женщин цетрореликс вызывает задержку подъема уровня ЛГ и, следовательно, овуляции. После однократного введения 3 мг цетрореликса действие препарата продолжается в течение не менее 4 дней (на 4-й день после введения секреторная функция угнетена на 70%). Регулярные введения цетрореликса по 0,25 мг каждые 24 ч поддерживают эффект препарата. Действие цетрореликса полностью обратимо после прекращения лечения."},{"name":"Фармакологическая группа","value":"гонадотропин-рилизинг гормона аналог"},{"name":"Форма выпуска","value":"лиофилизат для приготовления раствора для инъекций"},{"name":"Способ применения/введения","value":"подкожно","transition":{"type":"catalog","params":{"categorySlug":"mochepolovaia-sistema-i-polovye-gormony","categoryId":"15756910","navnodeId":"72506","glfilters":["35947170:36763730"]}}},{"name":"Пол","value":"для женщин","transition":{"type":"catalog","params":{"categorySlug":"mochepolovaia-sistema-i-polovye-gormony","categoryId":"15756910","navnodeId":"72506","glfilters":["14805991:14805993"]}}},{"name":"Комплектация","value":"в состав комплекта входит:\u003Cbr\u003E1 флакон с лиофилизатом;\u003Cbr\u003E1 предварительно заполненный шприц с растворителем;\u003Cbr\u003E1 игла (20G) в индивидуальной упаковке из бумаги и полимерной пленки;\u003Cbr\u003E1 игла (27G) в индивидуальной упаковке из бумаги и полимерной пленки;\u003Cbr\u003E2 тампона из нетканого материала, пропитанных 70 % изопропиловым спиртом, в двухслойном пакете из ламинированной фольги.\u003Cbr\u003EПо 1 или 7 комплектов (только дозировка 0,25 мг) в контурной ячейковой упаковке из пластика, запечатанного бумажной крышкой, вместе с инструкцией по применению в пачке картонной"},{"name":"Условия хранения","value":"Хранить при температуре не выше 25 °С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Передозировка препарата Цетротид может привести к увеличению длительности его действия, однако, это не сопровождается эффектами острой токсичности (в случае передозировки никакие специальные меры не требуются)."},{"name":"Применение при беременности и кормлении грудью","value":"Цетротид противопоказан к применению во время беременности и в период кормления грудью."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Цетротид не влияет на способность управлять автомобилем и другими механическими средствами."},{"name":"Особые указания","value":"Цетротид 0,25 мг лучше всего вводить регулярно через каждые 24 ч. При пропуске очередного введения препарата можно сделать инъекцию в любое другое время в течение этих же суток.\u003Cbr\u003EСледует соблюдать осторожность при применении препарата при наличии признаков и симптомов активного аллергического процесса или предрасположенности к аллергии в анамнезе; у женщин с тяжелыми аллергическими состояниями следует избегать применения препарата, в связи с чем, пациентке очень важно проинформировать лечащего врача обо всех имеющихся у нее проявлениях аллергии. Во время или после проведения стимуляции овуляции может возникнуть СГЯ, в этом случае проводят соответствующую терапию. Возникновение СГЯ расценивается в качестве неотъемлемого риска при процедуре стимуляции овуляции гонадотропинами. Для схем назначения гонадотропинов в комбинации с антагонистами ГнРГ наблюдалась корреляция с укороченным периодом стимуляции, а также меньшими дозами гонадотропинов и меньшими концентрациями эстрадиола. Эти наблюдения могут свидетельствовать о снижении риска появления СГЯ при применении антагонистов ГнРГ. СГЯ может быстро прогрессировать (от суток до нескольких дней) до тяжелого состояния, поэтому после введения ХГ необходимо проводить наблюдение в течение как минимум двух недель.\u003Cbr\u003EДля минимизации риска СГЯ регулярно применяют ультразвуковое исследование и оценку концентрации эстрадиола в плазме крови.\u003Cbr\u003EПри развитии тяжелой формы СГЯ терапия гонадотропинами, если она еще продолжается, должна быть прекращена. Пациентку следует госпитализировать и назначить специфическую для СГЯ терапию.\u003Cbr\u003EПоддержка лютеиновой фазы должна проводиться в соответствии с общепринятой практикой проведения вспомогательных репродуктивных технологий.\u003Cbr\u003EК настоящему времени опыт повторного проведения стимуляции овуляции с использованием Цетротида ограничен. Поэтому препарат при повторных курсах лечения следует использовать после оценки степени потенциального риска и эффективности лечения.\u003Cbr\u003EС осторожностью:При наличии признаков и симптомов активного аллергического процесса или предрасположенности к аллергии в анамнезе."},{"name":"Взаимодействие","value":"В исследованиях in vitro была продемонстрирована малая вероятность лекарственных взаимодействий при одновременном введении Цетротида с препаратами, метаболизм которых происходит с участием цитохрома Р450, или подвергающихся реакциям глюкуронизации или какой-либо другой конъюгации. Несмотря на то, что отсутствуют подтверждения о взаимодействии с другими широко применяемыми препаратами, в частности, с гонадотропинами и препаратами, потенциально индуцирующими выброс гистамина у пациентов с предрасположенностью к аллергии, нельзя полностью исключить вероятность лекарственного взаимодействия при одновременном их применении с Цетротидом. Следует сообщить лечащему врачу обо всех лекарственных препаратах, принимавшихся незадолго до начала лечения Цетротидом или принимаемых в настоящее время."},{"name":"Регистрационный номер","value":"П N014978/01"},{"name":"Дата государственной регистрации","value":"29.06.2021"},{"name":"Владелец регистрационного удостоверения","value":"Merck KGaA","transition":{"type":"catalog","params":{"categorySlug":"mochepolovaia-sistema-i-polovye-gormony","categoryId":"15756910","navnodeId":"72506","glfilters":["34324371:35649313","7893318:8513384"]}}},{"name":"Страна бренда","value":"Германия"},{"name":"Страна-производитель","value":"Франция"},{"name":"Название препарата","value":"Цетротид","transition":{"type":"catalog","params":{"categorySlug":"mochepolovaia-sistema-i-polovye-gormony","categoryId":"15756910","navnodeId":"72506","glfilters":["17796364:18031644"]}}},{"name":"Срок годности","value":"365 дн."}]}},"fullSpecsGrouped":{"16662246355695002217":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"половая система"},{"name":"Назначение","value":"предупреждение преждевременной овуляции"},{"name":"Показания к применению","value":"Предотвращение преждевременной овуляции у пациенток при контролируемой стимуляции овуляции для получения яйцеклеток и проведения вспомогательных репродуктивных технологий."},{"name":"Противопоказания","value":"Повышенная чувствительность к цетрореликса ацетату, любым другим структурным аналогам ГнРГ и другим экзогенным пептидным гормонам, маннитолу;\u003Cbr\u003E- беременность и период лактации;\u003Cbr\u003E- период постменопаузы;\u003Cbr\u003E- почечная или печеночная недостаточность средней или тяжелой степени."},{"name":"Состав","value":"В одном флаконе с препаратом в дозе 0,25 мг содержится:\u003Cbr\u003EДействующее вещество:\u003Cbr\u003EЦетрореликса ацетат, в пересчете на цетрореликс - 0,25 мг.\u003Cbr\u003EВспомогательное вещество:\u003Cbr\u003EМаннитол - 54,8 мг.\u003Cbr\u003EВ одном предварительно заполненном шприце с растворителем для дозы 0,25 мг содержится\u003Cbr\u003EВода для инъекций -1,0 мл."},{"name":"Действующее вещество","value":"Цетрореликс"},{"name":"Способ применения и дозы","value":"Цетротид может назначаться только специалистом-гинекологом. Для достижения максимальной эффективности лечения препаратом Цетротид следует внимательно ознакомиться с данными рекомендациями.\u003Cbr\u003EПосле первой инъекции пациентка 30 минут должна находиться под наблюдением врача, чтобы удостовериться в отсутствии аллергической или псевдоаллергической реакции на введение препарата. Все инструменты и препараты для купирования такой реакции должны быть в наличии.\u003Cbr\u003EЦетротид 0,25 мг\u003Cbr\u003EСодержимое 1 флакона (0,25 мг цетрореликса) следует вводить один раз в день через каждые 24 ч утром или вечером.\u003Cbr\u003EВведение препарата утром: лечение Цетротидом следует начинать на 5 или 6 день стимуляции яичников (приблизительно через 96-120 ч после начала стимуляции) препаратом гонадотропина, рекомбинантным или выделенным из мочи, и продолжать в течение всего периода стимуляции гонадотропином, включая день введения овуляторной дозы хорионического гонадотропина (ХГ).\u003Cbr\u003EВведение препарата вечером: лечение Цетротидом следует начинать на 5 день стимуляции яичников (приблизительно через 96-108 ч после начала стимуляции) препаратом гонадотропина, рекомбинантным или выделенным из мочи, и продолжать в течение всего периода стимуляции гонадотропином, включая вечер, предшествующий дню введения овуляторной дозы ХГ.\u003Cbr\u003EЦетротид 3,0 мг\u003Cbr\u003EСодержимое 1 флакона (3,0 мг цетрореликса) следует вводить на 7-й день стимуляции яичников (приблизительно через 132-144 ч после начала стимуляции) препаратом гонадотропина, рекомбинантным или выделенным из мочи.\u003Cbr\u003EПосле однократного введения 3,0 мг цетрореликса действие препарата продолжается в течение не менее 4 дней. Если на 5 день после введения Цетротида 3,0 мг размеры фолликулов не позволяют назначить индукцию овуляции, следует дополнительно ввести 0,25 мг цетрореликса (Цетротид 0,25 мг) один раз в сутки, начиная через 96 ч после введения препарата Цетротид 3,0 мг и включая день введения овуляторной дозы ХГ.\u003Cbr\u003EРекомендации по самостоятельному введению препарата Цетротид 0,25 мг и 3,0 мг (информация для пациента).\u003Cbr\u003EПервая инъекция должна быть сделана врачом-специалистом. После получения соответствующих инструкций врача о симптомах, которые могут свидетельствовать о возникновении аллергической реакции, о последствиях такой реакции и о необходимости ее лечения, пациентка может самостоятельно вводить Цетротид.\u003Cbr\u003EЦетротид вводят подкожно в нижнюю часть передней брюшной стенки, желательно в область вокруг пупка. Во избежание появления местного раздражения при повторном введении препарата, место инъекции следует ежедневно менять.\u003Cbr\u003EЦетротид следует разводить только в прилагаемом растворителе. Во время растворения флакон следует осторожно покачивать. Во избежание образования пузырьков, не следует применять энергичное встряхивание для ускорения растворения. Нельзя использовать раствор, если он непрозрачен или содержит нерастворенные частицы.\u003Cbr\u003EИз флакона следует набирать в шприц все его содержимое. Это позволит ввести дозу цетрореликса не менее 0,23 мг при использовании препарата Цетротид 0,25 мг и не менее 2,82 мг при использовании препарата Цетротид 3,0 мг. Раствор следует вводить сразу после его приготовления."},{"name":"Побочные действия","value":"Наиболее часто отмечались реакции в месте введения, такие как покраснение, зуд и припухлость, как правило, слабо выраженные и проходящие. В клинических исследованиях данные явления отмечались с частотой 9,4% после многократных инъекций Цетротида в дозе 0,25 мг.\u003Cbr\u003EПри процедуре стимуляции овуляции гонадотропинами относительно часто отмечался синдром гиперстимуляции яичников (СГЯ) от слабой до умеренной степени выраженности (I-II степени по классификации ВОЗ). На его появление могут указывать такие симптомы, как ощущение напряжения и боль в животе, тошнота, рвота, диарея, увеличение массы тела, увеличение яичников (см. раздел \"Особые указания\"). С другой стороны, тяжелый СГЯ (III ст. - по классификации ВОЗ) отмечался нечасто (к перечисленным симптомам СГЯ могут добавляться одышка, асцит, гиповолемия,\u003Cbr\u003Eгемоконцентрация, нарушение электролитного баланса, плевральный выпот, накопление\u003Cbr\u003Eжидкости в перикардиальной полости, олигурия, острый респираторный дистресс-синдром и тромбоэмболические нарушения).\u003Cbr\u003EРеакции гиперчувствительности, включая псевдоаллергические/анафилактоидные реакции (схожие по симптомам с аллергическими, но без выработки антител, и, как правило, проявляющиеся в той или иной степени в виде покраснения кожи, чувства жара, крапивницы, головной боли, затруднения дыхания) отмечались нечасто.\u003Cbr\u003EНиже представлены данные обо всех нежелательных реакциях, наблюдавшихся при применении Цетротида, в соответствии с общепринятой системно-органной классификацией, которые в зависимости от частоты возникновения подразделяются на очень частые (\u003E1/10 случаев применения), частые (\u003E1/100 и \u003C1/10), нечастые (\u003E1/1000 и \u003C1/100), редкие (\u003E1/10000 и \u003C1/1000) и очень редкие (\u003C1/10000).\u003Cbr\u003EНарушения со стороны иммунной системы\u003Cbr\u003EНечасто: системная аллергическая или псевдоаллергическая реакция, включая жизнеугрожающую анафилаксию.\u003Cbr\u003EНарушения со стороны нервной системы\u003Cbr\u003EНечасто: головная боль.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта\u003Cbr\u003EНечасто: тошнота.\u003Cbr\u003EНарушения со стороны половых органов и молочной железы\u003Cbr\u003EЧасто: легкий или умеренный СГЯ (I-II ст. по классификации ВОЗ);\u003Cbr\u003EНечасто: тяжелый СГЯ (III ст. по классификации ВОЗ).\u003Cbr\u003E\n\u003Cbr\u003EОбщие расстройства и нарушения в месте введения\u003Cbr\u003EЧасто: реакции в месте введения (покраснение, припухлость, зуд), как правило, преходящие и слабо выраженные."},{"name":"Фармакологическое действие","value":"Цетрореликс, являясь аналогом гонадотропин-рилизинг гормона (ГнРГ), связывается с рецепторами мембран клеток гипофиза и конкурентно тормозит связывание эндогенного ГнРГ этими рецепторами. Цетрореликс дозозависимо тормозит секрецию гонадотропинов гипофизом - лютеинизирующего (ЛГ) и фолликулостимулирующего (ФСГ) гормонов. В условиях отсутствия предварительной стимуляции начало угнетения секреторной функции гипофиза наступает фактически сразу после введения препарата продолжительность действия цетрореликса зависит от вводимой дозы. У женщин цетрореликс вызывает задержку подъема уровня ЛГ и, следовательно, овуляции. После однократного введения 3 мг цетрореликса действие препарата продолжается в течение не менее 4 дней (на 4-й день после введения секреторная функция угнетена на 70%). Регулярные введения цетрореликса по 0,25 мг каждые 24 ч поддерживают эффект препарата. Действие цетрореликса полностью обратимо после прекращения лечения."},{"name":"Фармакологическая группа","value":"гонадотропин-рилизинг гормона аналог"},{"name":"Форма выпуска","value":"лиофилизат для приготовления раствора для инъекций"},{"name":"Способ применения/введения","value":"подкожно"},{"name":"Пол","value":"для женщин"},{"name":"Комплектация","value":"в состав комплекта входит:\u003Cbr\u003E1 флакон с лиофилизатом;\u003Cbr\u003E1 предварительно заполненный шприц с растворителем;\u003Cbr\u003E1 игла (20G) в индивидуальной упаковке из бумаги и полимерной пленки;\u003Cbr\u003E1 игла (27G) в индивидуальной упаковке из бумаги и полимерной пленки;\u003Cbr\u003E2 тампона из нетканого материала, пропитанных 70 % изопропиловым спиртом, в двухслойном пакете из ламинированной фольги.\u003Cbr\u003EПо 1 или 7 комплектов (только дозировка 0,25 мг) в контурной ячейковой упаковке из пластика, запечатанного бумажной крышкой, вместе с инструкцией по применению в пачке картонной"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Хранить при температуре не выше 25 °С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Передозировка препарата Цетротид может привести к увеличению длительности его действия, однако, это не сопровождается эффектами острой токсичности (в случае передозировки никакие специальные меры не требуются)."},{"name":"Применение при беременности и кормлении грудью","value":"Цетротид противопоказан к применению во время беременности и в период кормления грудью."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Цетротид не влияет на способность управлять автомобилем и другими механическими средствами."},{"name":"Особые указания","value":"Цетротид 0,25 мг лучше всего вводить регулярно через каждые 24 ч. При пропуске очередного введения препарата можно сделать инъекцию в любое другое время в течение этих же суток.\u003Cbr\u003EСледует соблюдать осторожность при применении препарата при наличии признаков и симптомов активного аллергического процесса или предрасположенности к аллергии в анамнезе; у женщин с тяжелыми аллергическими состояниями следует избегать применения препарата, в связи с чем, пациентке очень важно проинформировать лечащего врача обо всех имеющихся у нее проявлениях аллергии. Во время или после проведения стимуляции овуляции может возникнуть СГЯ, в этом случае проводят соответствующую терапию. Возникновение СГЯ расценивается в качестве неотъемлемого риска при процедуре стимуляции овуляции гонадотропинами. Для схем назначения гонадотропинов в комбинации с антагонистами ГнРГ наблюдалась корреляция с укороченным периодом стимуляции, а также меньшими дозами гонадотропинов и меньшими концентрациями эстрадиола. Эти наблюдения могут свидетельствовать о снижении риска появления СГЯ при применении антагонистов ГнРГ. СГЯ может быстро прогрессировать (от суток до нескольких дней) до тяжелого состояния, поэтому после введения ХГ необходимо проводить наблюдение в течение как минимум двух недель.\u003Cbr\u003EДля минимизации риска СГЯ регулярно применяют ультразвуковое исследование и оценку концентрации эстрадиола в плазме крови.\u003Cbr\u003EПри развитии тяжелой формы СГЯ терапия гонадотропинами, если она еще продолжается, должна быть прекращена. Пациентку следует госпитализировать и назначить специфическую для СГЯ терапию.\u003Cbr\u003EПоддержка лютеиновой фазы должна проводиться в соответствии с общепринятой практикой проведения вспомогательных репродуктивных технологий.\u003Cbr\u003EК настоящему времени опыт повторного проведения стимуляции овуляции с использованием Цетротида ограничен. Поэтому препарат при повторных курсах лечения следует использовать после оценки степени потенциального риска и эффективности лечения.\u003Cbr\u003EС осторожностью:При наличии признаков и симптомов активного аллергического процесса или предрасположенности к аллергии в анамнезе."},{"name":"Взаимодействие","value":"В исследованиях in vitro была продемонстрирована малая вероятность лекарственных взаимодействий при одновременном введении Цетротида с препаратами, метаболизм которых происходит с участием цитохрома Р450, или подвергающихся реакциям глюкуронизации или какой-либо другой конъюгации. Несмотря на то, что отсутствуют подтверждения о взаимодействии с другими широко применяемыми препаратами, в частности, с гонадотропинами и препаратами, потенциально индуцирующими выброс гистамина у пациентов с предрасположенностью к аллергии, нельзя полностью исключить вероятность лекарственного взаимодействия при одновременном их применении с Цетротидом. Следует сообщить лечащему врачу обо всех лекарственных препаратах, принимавшихся незадолго до начала лечения Цетротидом или принимаемых в настоящее время."},{"name":"Регистрационный номер","value":"П N014978/01"},{"name":"Дата государственной регистрации","value":"29.06.2021"},{"name":"Владелец регистрационного удостоверения","value":"Merck KGaA"},{"name":"Страна бренда","value":"Германия"},{"name":"Страна-производитель","value":"Франция"},{"name":"Название препарата","value":"Цетротид"},{"name":"Срок годности","value":"365 дн."}]}],"transitionId":"tr_15808522865222479863"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

Где купить

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13 942 ₽

  • Сегодня, самовывоз • 0 ₽
ЕАПТЕКА
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{"widgets":{"@market/CartService":{}},"meta":{"/content/page/fancyPage/cartService":{"name":"@market/CartService"}},"collections":{"sku":{},"product":{},"shop":{},"initialCartItem":{},"promo":{}}}

Ещё может подойти

  • Овитрель р-р для п/к введ., 250 мкг/0.5 мл, 1 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ltgi4kx3cki/toggleWishlist":{"skuId":"265318692","productId":1778175713,"offerId":"I36WtGOdC0Rz-eLttzKO_Q","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQzcqOlqbUkuWHARIxCi9Db21wZXRpdGl2ZUFuYWxvZ3NfTWFya2V0TW9kZWxDYXJkX0Zyb250U25pcHBldDIVCOGd888GEKTiwX4Y6M6HBCDu3MEH","sign":"TczbY2QoLrOXwqq4r19hVSsr4cYE2v/+lt0XaJfEpZM="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ltgi4kx3cki/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Овитрель р-р для п/к введ., 250 мкг/0.5 мл, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 5 654 ₽
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шт.","label":"n92fnnd3tiq","count":0,"features":[],"imageMeta":{"namespace":"mpic","groupId":4252138,"key":"img_id6756156501576751119.jpeg"}},"quantity":{"step":1,"minimum":1,"maximum":999},"cpaUrl":"/safeclick/data=TxNGOK9vJEN7oLFLeCTKEixJYuEMI0EzvZFs82AjjgjhTwweZ7mRXd_AQ0K184sfZmy5nQz7U8xIc-qdVOMFoxnoSww2ObzLEs1KJpltGipDSanCui6QCo8GXRHxAQaqQQZbzp5kb0bdQDXqQiIIDEwL4INEBUjrbUNtjxqZ96WFVmZtSFtMyd00zHc5eP2a4OrrJritdvgtYloRnLnIZlUgVJ33QN9H3MBjDnMRVfkGzGpsEB_Lb3p1TMoTd_JbUyKmTf54lFRgaVI4QWa5GPrqZQa-LV8h8BDj726NeATHic0zy8Jc7IoqX6g0hrZ-s0HIL-MNhRdRywIBfnkUXJLGUzT_NxXAIW4HN9Wy3wXegrYQrJHV24PD7RS47WSiMuWGAchdOvMKcZBcY9061YYA1s2BYMk_iBobymWzd36Hvz2jwXpwK2dp--Qe4rD_YYsXrGMyvxr7LV7KUwk3j1JyQyeU7B-zRrhMUa_Y0M1oL46k_PSL_aKTcpQsr_4FXTc2a1zfkSOODZn_qZMhbXJwaml7u_eShFJBX4CsNPhcGSBiHRte8tYPtdJfC6_fatf7RnifyjMDveJZ6vTnVMXA4G4wvrQ85fMRO1EPjlhvWeJp5fkzS9wVZ6ZagITDq2Bfdip1FL9o24D7cQOEP4jgaM-kr1baiYwsF6Meg9vIjrc7JRADdDzqnjy8nwVmA5Ngqh773HlKGdvB9P5ECeA6JqNLdcXg4tnR6SEc-E4NsXva0mw0oNaQxY5IEKrlUGKb3BMkmHalgP73gzL2PahB0dDE0rJJ39q0DEgDFhKZBfrO2ASAa1rRqI9hxa6QdRWlgYrqEFd3uitATeF8Bvip6qLgx0lUvpdEpQquvSla6_T9SltqdCrAr2VP0_Zh0tOzWs4l2KVAv7x1ai05ngou-M2RCdot9HPLMSlzHRotZ2Qk4m9SO1ZGeGdSt_3ZVUQe6k1xCui_9KCMMY9FdGeAnzVaFuhJW3FoYaJIQOCKFpMBiwMX7q2fuG1DJkGv0kq_mn9FuSFuPmiHXS-mRXOhQbU0n9R_JnWxJUayGdvv8Q5vp0TCf4gdWyxY3ITCKAcUb11Ym_vp8gnq79eOYccoHs0cS55V7gXPm-M_Olbf3BkagQLhgu7VysDNBgZGbILnha_1jDXvbdjgEH8kI0_98o8Pvhh90CGq9ZmaSUXSQnDrCQVj8tluPyR5H0Y9Dc6aFNufUcMeMQaWxkR6oDwqLwz0O0knlSPL67S1UkGe_KFoSxnTTwtOGmq-4lQYoqsXRPqZXeSVZMgpueRmWW_4XWxeUN0fuloulLryPUk-yM_sUzXB8rjiHSMzlZ2aH0JzBQe-_XZlsFYvuLJ-3Dz8pPDzFaKX794kkxW4UBzoeYlCybwBS_qGHEKbcIS4w5pMeEkdfWx-s74Y5dln2WeqBw4TbVjGVRyMHFgWVBiQvIFmfBfCpwI6CA3gK2z_hkFzggDwpNiQj0u6kRHeIYEHuvFuPQMr_WqPKRaG5EykKw3f2rix_NC8HtNr_fk75wgnQqEgIuy77VSUsXnckz1INsnHwJw-TNpSV78nsKMdx_5CkoZCS9c35hbbbvzz_olO8RNrMJzL518or5TiZQaNZiHCVEXvWjH2EQryg2m03G1SpyXLCDSHNJIB6wCddKIW1Ry5-Y1It7pUnnjA0AvC7uq8d5g9K6ji25fDZ3KtQyjEwQ1BHwtIr24TQpr6_LuWTjM-ITwS9dAWJvU2TafjplfmrVFRCPzpmnYMOo5S8leGH4T3JF9pA6koVKxHfS_9EJkiAwnXhPNcYO-DmJKzqxvhKhSPlnQf6wBDfAeMQSvchQRXsb6GytSJ1RPLi-Z-LLFpKVRz2uDRFkfHW2tdEzAxx70A5Y_873_OQRITeOoV1U8l3i-CJ8eZFvsGmWPj8p3FoLGSE8pH5DuT0X6iljBW5j9oaiUVIe8ii0_bqQ0sQa_L-8PRLtdZk6FVSE9ExePKSPuKFp0t6yVImKZPyAH-QgzglcCjCLq8y8P8vsAxTs9TDBU3J9Ho19ZE6c76LU9hmih_bZ8PAAlaKk-BkfwnhfUzyq5trVoxD176U4tMdWxRycPIOOlbyyKrP_qJupfVOcnzKivRuAMP-Qt-f0aMDuzvXvXTMbzyzK3OubVgkoxbsDFuewU9Kx4VuBazZJC_z5FMIpFo3cIOlSZPxefTQk0jIVXleG7k35fd08rz6P-tG1NpuzDKuBb15qpMrjEPx-uj-cqERA5jxzN-89dUE_99occ5xfqAIS2CZg06-vn1Slx5rgWEqp1K9oppKPF5OGfrobtd7anidZW3px12bsHY7673FDDJNj4RwLQwWCFdx1ubN8o9D0x8OdBrWpoTMTHm0PCNqQXpw6BqVuVAiKUFPOJhzbWmla1-DnHN15hwyAhPvTw9tVdJ43pAnSynHZi135dKSUmxUmHEUW9NXc2gd78or-gRYej0BcjWlp5Mz72od5mvBoNtWJSft2R1NwWVUgC904Qk9g8xXeu8xMLv5hIKYlGGfkqWT3nRnoS5RMURd_EPsU_oRMZ_W2wdcuWk6nHni0WXZA8QkS-g285BnXFIaV03meV5yazhj1VVprbb9uJaJNtDt4AACTSk5o1WGVhIvK-HpfQVsQq1mq8jKthcNQgZPHqoPWv6xOOEBxdaIDkGA-g1tfqwziUAjFXZ3AoEIh3T2XddyATj70dFhVYvhRUWammFKp4MfQ2klVWaJoAUcGNkcjqP-EHYoV-PfdEGO4IKxOq8r515a60AMl_wwZU84zPsnflLASanbvqnzEAMSs853DAxqAfD5Zd8WQNAhQskhQHaLqyzIalgo32bLBb99ZlixeQflkpjhuYCdbYOn93Ah0YRqwhPOH26ZbmfqDFJLa_5vGui87kgUunNuwizHwxqrn67_oGvqgkFOXSWnQExSfBCTRZIbV-IPTEyRkyhk83CpLWt0GC4SVjchcGbjJ99ymBb4zCnuQoAJNjkMQlDnW5vaR_KKwJrA7WrssPUUTs1E7xp7QlH0QH2ZReDUEiP5UTYZ5HJsMybXf85LKECvQ97LptH5MMrHw1QVbrBQyP1yiLrPR_R4s_L2LhTsteYtYuF4rg5nsb7a3qb1WwCqP1InpMNQenwTnyqxK1OMCqCv063-TNn5rztAoJAmcwZ0GPnjL1IT6W7MeaM6EahDx41kjyyptP5Zw70V1l6mhQ_BiGDCCE6qLtQUOgZGyy2-oAwUny0jahNDsbQjYnzTSzPKw2kQjvrQchOXjac8s_3fa1A7SlDxme1O60AgXwGrqGjoVhgQYOZ4mMWlBciKRX3SzmjNygOh2J-qpYoDlhMegTL16Qgk1ZAKMJOdDXc0sCUVc6kU4w-Bo0rGqSbfy2tM594owXkYnwPsNg0_StbSWUXnFl3EmV2tjdLTCNdkeieF_vb_iuTNt3KIoHxwTYbWGIIR5jITaWooP6N0w,,/b64e=1/sign=d7a50f3fe80c28ccf152f0e6e7a20044/keyno=MARKET_1/*","showUid":"17179702543166830564706001","cartLink":"/my/cart","showNotificationWhenDeleteItem":true,"isLavka":false,"isError":false,"isEats":false,"isCR":false,"isM2bEdoOnlyEnable":false,"isEatsMarketIntegration":true,"isCartButtonNext":false,"isUpsalePopupCRExp":false,"baobabClientDataAdditionToCart":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQzcqOlqbUkuWHARIxCi9Db21wZXRpdGl2ZUFuYWxvZ3NfTWFya2V0TW9kZWxDYXJkX0Zyb250U25pcHBldDIVCOGd888GEKTiwX4Y6M6HBCDu3MEH","sign":"TczbY2QoLrOXwqq4r19hVSsr4cYE2v/+lt0XaJfEpZM="},"target":"cart_addition"},"baobabClientDataDeletionFromCart":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQzcqOlqbUkuWHARIxCi9Db21wZXRpdGl2ZUFuYWxvZ3NfTWFya2V0TW9kZWxDYXJkX0Zyb250U25pcHBldDIVCOGd888GEKTiwX4Y6M6HBCDu3MEH","sign":"TczbY2QoLrOXwqq4r19hVSsr4cYE2v/+lt0XaJfEpZM="},"target":"cart_deletion"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ltgi4kx3cki/addToCartButton":{"name":"@light/AddToCartButtonSnippet"}}}
  • Пурегон р-р для п/к введ., 300 МЕ/0.36 мл
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-lor80sy8io/toggleWishlist":{"skuId":"704532021","productId":1430912618,"offerId":"jZJ-Hm-xjtSYs4rVcVdW3w","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQzcqOlqbUkuWHARIxCi9Db21wZXRpdGl2ZUFuYWxvZ3NfTWFya2V0TW9kZWxDYXJkX0Zyb250U25pcHBldDIWCOr8p6oFELWc+c8CGITcsAgg7tzBBw==","sign":"GxoKdIyqBG877Wt92rbbBQI+RcWH1YnN58/fckf1I6U="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-lor80sy8io/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Пурегон р-р для п/к введ., 300 МЕ/0.36 мл

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 5 778 ₽
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  • Гонадотропин хорионический лиоф. для приг. р-ра д/в/м введ., 1000 ME, 5 шт.
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    Гонадотропин хорионический лиоф. для приг. р-ра д/в/м введ., 1000 ME, 5 шт.

    Рейтинг товара: 4.8 из 5
    на основе 56 оценок
    Цена 2 500 ₽
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  • Оргалутран р-р для п/к введ., 0.25 мг/0.5 мл, 0.5 мл, 5 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-n7kxy7gxtyd/toggleWishlist":{"skuId":"655122048","productId":1778175844,"offerId":"-Knr0gI2uSlcWezpM5DVcw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQzcqOlqbUkuWHARIxCi9Db21wZXRpdGl2ZUFuYWxvZ3NfTWFya2V0TW9kZWxDYXJkX0Zyb250U25pcHBldDIWCOSe888GEIC9sbgCGITcsAgg7tzBBw==","sign":"HmtSuDCP5i9YgGTK+mR7qfhWLeNf8pwoWnS/mhxEn4o="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-n7kxy7gxtyd/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Оргалутран р-р для п/к введ., 0.25 мг/0.5 мл, 0.5 мл, 5 шт.

    Рейтинг товара: 4.5 из 5
    на основе 2 оценки
    Цена 6 182 ₽
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  • Синэстрол р-р д/ин. масл., 1 мг/мл, 1 мл, 10 шт.
    –5 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-85fo08nva3/toggleWishlist":{"skuId":"949285346","productId":1430912559,"offerId":"u5YSmlyjiIWCqL3WQqM0qQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQzcqOlqbUkuWHARIxCi9Db21wZXRpdGl2ZUFuYWxvZ3NfTWFya2V0TW9kZWxDYXJkX0Zyb250U25pcHBldDIWCK/8p6oFEOLj08QDGJ2BzwYg7tzBBw==","sign":"Rlmm/BEEzFsdGSe1jt1EK391r360EcQWgz6di2p/xpA="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-85fo08nva3/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Синэстрол р-р д/ин. масл., 1 мг/мл, 1 мл, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 385 ₽ вместо 406
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  • Пинеамин лиоф. д/приг. р-ра для в/м введ., 10 мг, 10 шт.
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    Пинеамин лиоф. д/приг. р-ра для в/м введ., 10 мг, 10 шт.

    Рейтинг товара: 4.4 из 5
    на основе 21 оценка
    Цена 30 117 ₽
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  • Элонва р-р для в/м введ., 150 мкг/0.5 мл, 0.5 мл, 1 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-x508pjvojy/toggleWishlist":{"skuId":"701578027","productId":1430912616,"offerId":"6qG7ePkT1qXhYDRi6SqWdQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQzcqOlqbUkuWHARIxCi9Db21wZXRpdGl2ZUFuYWxvZ3NfTWFya2V0TW9kZWxDYXJkX0Zyb250U25pcHBldDIWCOj8p6oFEKv2xM4CGITcsAgg7tzBBw==","sign":"bFO4DlIbZUgqLPfwbatZDBDXoT9F+V2pZxzH2n8fhrk="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-x508pjvojy/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Элонва р-р для в/м введ., 150 мкг/0.5 мл, 0.5 мл, 1 шт.

    Цена 22 651 ₽
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  • Оксипрогестерона капронат р-р д/ин. масл., 125 мг/мл, 1 мл, 10 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-jo8z9fs3h1/toggleWishlist":{"skuId":"101521071730","productId":265144251,"offerId":"CfltAs3WPQebxtmo4WpjtQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQzcqOlqbUkuWHARIxCi9Db21wZXRpdGl2ZUFuYWxvZ3NfTWFya2V0TW9kZWxDYXJkX0Zyb250U25pcHBldDIWCLuPt34Q8ryCmfoCGJ2BzwYg7tzBBw==","sign":"NrX2gK22Ag1nJmgoZH3QM2b8mlfZ+62NSqtRZ+BJ5b0="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-jo8z9fs3h1/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Оксипрогестерона капронат р-р д/ин. масл., 125 мг/мл, 1 мл, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 4 оценки
    Цена 1 138 ₽
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  • Трактоцил конц. д/приг. р-ра д/инф. фл., 7,5 мг/мл, 5 мл
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    Трактоцил конц. д/приг. р-ра д/инф. фл., 7,5 мг/мл, 5 мл

    Цена 5 242 ₽
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  • Андродоз капс., 60 шт.
    –2 %
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    Андродоз капс., 60 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 4 398 ₽ вместо 4 488
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  • Андрогель гель д/нар. прим., 50 мг, 5 г, 30 шт.
    –11 %
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    Андрогель гель д/нар. прим., 50 мг, 5 г, 30 шт.

    Рейтинг товара: 4.8 из 5
    на основе 129 оценок
    Цена 3 233 ₽ вместо 3 632
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  • Спазмекс таб. п/о плен., 30 мг, 30 шт.
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    Спазмекс таб. п/о плен., 30 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 4 оценки
    Цена 816 ₽
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Инструкция

Показания к применению

Предотвращение преждевременной овуляции у пациенток при контролируемой стимуляции овуляции для получения яйцеклеток и проведения вспомогательных репродуктивных технологий.

Противопоказания

Повышенная чувствительность к цетрореликса ацетату, любым другим структурным аналогам ГнРГ и другим экзогенным пептидным гормонам, маннитолу;
- беременность и период лактации;
- период постменопаузы;
- почечная или печеночная недостаточность средней или тяжелой степени.

Способ применения и дозы

Цетротид может назначаться только специалистом-гинекологом. Для достижения максимальной эффективности лечения препаратом Цетротид следует внимательно ознакомиться с данными рекомендациями.
После первой инъекции пациентка 30 минут должна находиться под наблюдением врача, чтобы удостовериться в отсутствии аллергической или псевдоаллергической реакции на введение препарата. Все инструменты и препараты для купирования такой реакции должны быть в наличии.
Цетротид 0,25 мг
Содержимое 1 флакона (0,25 мг цетрореликса) следует вводить один раз в день через каждые 24 ч утром или вечером.
Введение препарата утром: лечение Цетротидом следует начинать на 5 или 6 день стимуляции яичников (приблизительно через 96-120 ч после начала стимуляции) препаратом гонадотропина, рекомбинантным или выделенным из мочи, и продолжать в течение всего периода стимуляции гонадотропином, включая день введения овуляторной дозы хорионического гонадотропина (ХГ).
Введение препарата вечером: лечение Цетротидом следует начинать на 5 день стимуляции яичников (приблизительно через 96-108 ч после начала стимуляции) препаратом гонадотропина, рекомбинантным или выделенным из мочи, и продолжать в течение всего периода стимуляции гонадотропином, включая вечер, предшествующий дню введения овуляторной дозы ХГ.
Цетротид 3,0 мг
Содержимое 1 флакона (3,0 мг цетрореликса) следует вводить на 7-й день стимуляции яичников (приблизительно через 132-144 ч после начала стимуляции) препаратом гонадотропина, рекомбинантным или выделенным из мочи.
После однократного введения 3,0 мг цетрореликса действие препарата продолжается в течение не менее 4 дней. Если на 5 день после введения Цетротида 3,0 мг размеры фолликулов не позволяют назначить индукцию овуляции, следует дополнительно ввести 0,25 мг цетрореликса (Цетротид 0,25 мг) один раз в сутки, начиная через 96 ч после введения препарата Цетротид 3,0 мг и включая день введения овуляторной дозы ХГ.
Рекомендации по самостоятельному введению препарата Цетротид 0,25 мг и 3,0 мг (информация для пациента).
Первая инъекция должна быть сделана врачом-специалистом. После получения соответствующих инструкций врача о симптомах, которые могут свидетельствовать о возникновении аллергической реакции, о последствиях такой реакции и о необходимости ее лечения, пациентка может самостоятельно вводить Цетротид.
Цетротид вводят подкожно в нижнюю часть передней брюшной стенки, желательно в область вокруг пупка. Во избежание появления местного раздражения при повторном введении препарата, место инъекции следует ежедневно менять.
Цетротид следует разводить только в прилагаемом растворителе. Во время растворения флакон следует осторожно покачивать. Во избежание образования пузырьков, не следует применять энергичное встряхивание для ускорения растворения. Нельзя использовать раствор, если он непрозрачен или содержит нерастворенные частицы.
Из флакона следует набирать в шприц все его содержимое. Это позволит ввести дозу цетрореликса не менее 0,23 мг при использовании препарата Цетротид 0,25 мг и не менее 2,82 мг при использовании препарата Цетротид 3,0 мг. Раствор следует вводить сразу после его приготовления.
Полная инструкция
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Цетротид лиоф д/приг. р-ра п/к введ. фл.
Цетротид лиоф д/приг. р-ра п/к введ. фл., 7 шт.
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