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Описание

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Трентал таб. п/о плен. кш/раств., 100 мг, 60 шт.

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4.6
(8)
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Коротко о товаре

Артикул Маркета
3123237216
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
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100 мг;\u003Cbr\u003Eвспомогательные вещества: лактоза - 20,00 мг, крахмал - 30,00 мг, тальк - 8,50 мг, кремния диоксид коллоидный - 0,50 мг, магния стеарат - 1,00 мг.\u003Cbr\u003EОболочка: метакриловой кислоты сополимер - 11,45 мг, натрия гидроксид - 0,168 мг, макрогол (полиэтиленгликоль) 8000 - 1,40 мг, тальк - 0,388 мг, титана диоксид (Е 171) - 1,272 мг.\u003Cbr\u003E"},{"name":"Действующее вещество","value":"Пентоксифиллин","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["27144131:28710332"]}}},{"name":"Способ применения и дозы","value":"Дозировка устанавливается врачом в соответствии с индивидуальными особенностями больного.\u003Cbr\u003EОбычная доза составляет: одна таблетка Трентала три раза в сутки с последующим медленным повышением дозы до 200 мг 2-3 раза в сутки. Максимальная разовая доза - 400 мг. Максимальная суточная доза - 1200 мг. Препарат следует проглатывать целиком во время или сразу после приема пищи, запивая достаточным количеством воды.\u003Cbr\u003EУ пациентов с нарушенной функцией почек (клиренс креатинина ниже 30 мл/мин) дозировка может быть снижена до 1-2 таблеток в сутки.\u003Cbr\u003EУменьшение дозы, с учетом индивидуальной переносимости, необходимо у пациентов с тяжелым нарушением функции печени.\u003Cbr\u003EЛечение может быть начато малыми дозами у пациентов с низким артериальным давлением, а также у лиц, находящихся в группе риска ввиду возможного снижения артериального давления (пациенты с тяжелой формой ИБС или с гемодинамически значимыми стенозами сосудов головного мозга). В этих случаях доза может быть увеличена только постепенно.\u003Cbr\u003E"},{"name":"Побочные действия","value":"Ниже представлены побочные реакции, которые отмечались в клинических исследованиях и при постмаркетинговом применении препарата (частота неизвестна).\u003Cbr\u003EНарушении со стороны нервной системы: головная боль, головокружение, асептический менингит, судороги.\u003Cbr\u003EНарушения психики: ажитация, нарушения сна, тревога.\u003Cbr\u003EНарушения со стороны сердца: тахикардия, аритмия, снижение артериального давления, стенокардия.\u003Cbr\u003EНарушения со стороны сосудов: \"приливы\" крови к кожным покровам, кровотечения (в том числе, кровотечения из сосудов кожи, слизистых оболочек, желудка, кишечника).\u003Cbr\u003EНарушения со стороны пищеварительной системы: ксеростомия (сухость полости рта), анорексия, атония кишечника, чувство давления и переполнения в области желудка, тошнота, рвота, диарея, запор, гиперсаливация (повышенное слюноотделение).\u003Cbr\u003EНарушения со стороны печени и желчевыводящих путей: внутрипеченочный холестаз, повышение активности \"печеночных\" трансаминаз, повышение активности щелочной фосфатазы.\u003Cbr\u003EНарушении со стороны крови и лимфатической системы: лейкопения/нейтропения, тромбоцитопения, панцитопения, гипофибриногенемия.\u003Cbr\u003EНарушении со стороны органа зрении: нарушение зрения, скотома.\u003Cbr\u003EНарушении со стороны кожи и подкожных тканей: кожный зуд, эритема (покраснение кожи), крапивница, повышенная ломкость ногтей, отеки.\u003Cbr\u003EНарушении со стороны иммунной системы: анафилактические/анафилактоидные реакции, ангионевротический отек, анафилактический шок, бронхоспазм.\u003Cbr\u003E"},{"name":"Фармакологическое действие","value":"Препарат Трентал уменьшает вязкость крови и улучшает реологические свойства крови (текучесть) за счет:\u003Cbr\u003E- улучшения нарушенной деформируемости эритроцитов;\u003Cbr\u003E- уменьшения агрегации тромбоцитов и эритроцитов;\u003Cbr\u003E-снижения концентрации фибриногена;\u003Cbr\u003E- снижения активности лейкоцитов и уменьшения адгезии лейкоцитов к эндотелию сосудов.\u003Cbr\u003EВ качестве активного вещества препарат Трентал содержит производное ксантина - пентоксифиллин. Механизм его действия связан с ингибированием фосфодиэстеразы и накоплением циклического аденозинмонофосфата (цАМФ) в клетках гладкой мускулатуры сосудов и форменных элементах крови.\u003Cbr\u003EОказывая слабое миотропное сосудорасширяющее действие, пентоксифиллин несколько уменьшает общее периферическое сосудистое сопротивление и незначительно расширяет коронарные сосуды.\u003Cbr\u003EПентоксифиллин обладает слабым положительным инотропным эффектом на сердце.\u003Cbr\u003EУлучшает микроциркуляцию в зонах нарушенного кровообращения. Лечение препаратом Трентал приводит к улучшению симптоматики нарушений мозгового кровообращения.\u003Cbr\u003EПри окклюзионных заболеваниях периферических артерий применение препарата Трентал приводит к удлинению дистанции ходьбы, устранению ночных судорог в икроножных мышцах и исчезновению болей в покое.\u003Cbr\u003E"},{"name":"Фармакологическая группа","value":"вазодилататоры"},{"name":"Форма выпуска","value":"таблетки, покрытые кишечнорастворимой оболочкой"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"Хранить в сухом месте при температуре не выше 25 С. Хранить в недоступном для детей месте!"},{"name":"Передозировка","value":"Симптомы передози ровки: головокружение, тошнота, рвота типа \"кофейной гущи\", снижение артериального давления, тахикардия, аритмия, покраснение кожных покровов, потеря сознания, озноб, арефлексия, тонико-клонические судороги.\u003Cbr\u003EВ случае возникновения описанных выше нарушений необходимо срочно обратиться к врачу.\u003Cbr\u003EЛечение симптоматическое. При появлении первых признаков передозировки (потливость, тошнота, цианоз) немедленно прекращают прием препарата. Если препарат принят недавно, следует обеспечить меры, направленные на предотвращение дальнейшего всасывания препарата путем его выведения (промывание желудка) или замедления всасывания (например, прием активированного угля).\u003Cbr\u003EОсобое внимание должно быть направлено на поддержание артериального давления и функции дыхания. При судорожных припадках вводят диазепам.\u003Cbr\u003EСпецифический антидот неизвестен.\u003Cbr\u003E"},{"name":"Применение при беременности и кормлении грудью","value":"Беременность\u003Cbr\u003EПрепарат Трентал не рекомендуется к применению при беременности (так как недостаточно данных).\u003Cbr\u003EПериод грудного вскармливания\u003Cbr\u003EПенгоксифиллин проникает в грудное молоко в незначительных количествах.\u003Cbr\u003EПри необходимости применения препарата следует прекратить грудное вскармливание (учитывая отсутствие опыта применения).\u003Cbr\u003E"},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Учитывая возможные побочные эффекты (например, головокружение), следует соблюдать осторожность при вождении автотранспорта и занятиях потенциально опасными видами деятельности.\u003Cbr\u003E"},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EТяжелые нарушения ритма сердца (риск ухудшения аритмии).\u003Cbr\u003EАртериальная гипотензия (риск дальнейшего снижения артериального давления, см. раздел «Способ применения и дозы»).\u003Cbr\u003EХроническая сердечная недостаточность.\u003Cbr\u003EЯзвенная болезнь желудка и двенадцатиперстной кишки.\u003Cbr\u003EНарушения функции почек\u003Cbr\u003EТяжелые нарушения функции печени (риск кумуляции и повышенный риск побочных эффектов, см. раздел «Способ применения и дозы»).\u003Cbr\u003EНедавно перенесенные оперативные вмешательства.\u003Cbr\u003EПовышенный риск развития кровотечений (например, при нарушениях в системе свертывания крови (риск развития более тяжелых кровотечений), см. раздел «Взаимодействие с другими лекарственными средствами»).\u003Cbr\u003EОдновременное применение с антикоагулянтами (в том числе, непрямыми антикоагулянтами [антагонистами, витамина К]) (см. раздел «Взаимодействие с другими лекарственными средствами»).\u003Cbr\u003EОдновременное применение с ингибиторами агрегации тромбоцитов (клопидогрел, эптифибатид, тирофибан, эпопростенол, илопрост, абциксимаб, анагрелид, НПВП [кроме селективных ингибиторов циклооксигеназы-2], ацетилсалициловая кислота, тиклопидин, дипиридамол) (см. раздел «Взаимодействие с другими лекарственными средствами»).\u003Cbr\u003EОдновременное применение с гипогликемическими средствами (инсулином и гипогликемическими средствами для приема внутрь), см. раздел «Взаимодействие с другими лекарственными средствами».\u003Cbr\u003EОдновременное применение с ципрофлоксацином (см. раздел «Взаимодействие с другими лекарственными средствами»).\u003Cbr\u003EОдновременное применение с теофиллином (см. раздел «Взаимодействие с другими лекарственными средствами»).\u003Cbr\u003EОсобые указания:\u003Cbr\u003EЛечение следует проводить под контролем артериального давления.\u003Cbr\u003EУ пациентов с сахарным диабетом, принимающих гипогликемические средства, назначение больших доз может вызвать выраженную гипогликемию (может потребоваться коррекция доз гипогликемических средств и проведение гликемического контроля).\u003Cbr\u003EПри назначении препарата Трентал одновременно с антикоагулянтами необходим контроль показателей свертывающей системы крови.\u003Cbr\u003EУ пациентов, недавно перенесших оперативное вмешательство, необходим регулярный контроль гемоглобина и гематокрита. Пациентам с низким и нестабильным артериальным давлением необходимо уменьшить дозу пентоксифиллина.\u003Cbr\u003EУ пожилых пациентов может потребоваться уменьшение дозы пентоксифиллина (повышение биодоступиости и снижение скорости выведения).\u003Cbr\u003EБезопасность и эффективность пентоксифиллина у детей изучены недостаточно.\u003Cbr\u003EКурение может снижать терапевтическую эффективность препарата.\u003Cbr\u003E"},{"name":"Взаимодействие","value":"С гипотензивными средствами\u003Cbr\u003EПентоксифиллин повышает риск развития артериальной гипотензии при одновременном применении с гипотензивными средсгвам и (например, ингибиторы ангиотензинпревращающего фермента (АПФ)) или другими лекарственными средствами, обладающими потенциальным антигипертензивным эффектом (например, нитраты);\u003Cbr\u003EС лекарственными средствами, влияющими на свертывающую систему крови\u003Cbr\u003EПентоксифиллин может усиливать действие лекарственных средств, влияющих на свертывающую систему крови (прямые и непрямые анти коагулянты, тромболити ки, антибиотики, такие как цефалоспорины).\u003Cbr\u003EПри совместном применении пентоксифиллина и непрямых антикоагулянтов (антагонистов витамина К) в постмаркетинговых исследованиях отмечались случаи усиления антикоагулянтного действия (риск развития кровотечений). Поэтому в начале приема пентоксифиллина или изменении его дозы рекомендуется контролировать степень выраженности антикоагулянтного действия у пациентов, принимающих данную комбинацию препаратов, например, проводить регулярный контроль МНО (международное нормализованное отношение).\u003Cbr\u003EС циметидином\u003Cbr\u003EЦиметидин повышает концентрацию пентоксифиллина и активного метаболита I в плазме крови (риск возникновения побочных реакций).\u003Cbr\u003EС другими ксантинами\u003Cbr\u003EСовместное назначение с другими ксантинами может приводить к чрезмерному нервному возбуждению.\u003Cbr\u003EС гипогликемическими средствами (инсулином и гипогликемическими средствами для приема внутрь)\u003Cbr\u003EГипогликемическое действие инсулина или гипогликемических средств для приема внутрь может усиливаться при одновременном применении пентоксифиллина (повышенный риск развития гипогликемии). Необходим строгий контроль состояния таких пациентов, включая регулярный гликемический контроль.\u003Cbr\u003EС теофиллином\u003Cbr\u003EУ некоторых пациентов при одновременном применении пентоксифиллина и теофиллина отмечается увеличение концентрации теофиллина. В дальнейшем это может приводить к увеличению или усилению побочных действий, связанных с теофиллином.\u003Cbr\u003EС ципрофлоксацином\u003Cbr\u003EУ некоторых пациентов при одновременном применении пентоксифиллина и ципрофлоксацина увеличение концентрации пентоксифиллина в плазме крови. В дальнейшем это может приводить к увеличению или усилению побочных действий, связанных с применением данной комбинации.\u003Cbr\u003EС ингибиторами агрегации тромбоцитов\u003Cbr\u003EПри одновременном применении пентоксифиллина с ингибиторами агрегации тромбоцитов (клопидогрел, эптифибатид, тирофибан, эпопростенол, илопрост, абциксимаб, анагрелид, НПВП [кроме селективных ингибиторов циклооксигеназы-2], ацетилсалициловая кислота, тиклопидин, дипиридамол) возможно развитие потенциального аддитивного действия, увеличивающего риск развития кровотечения. Поэтому из-за риска развития кровотечения следует с осторожностью применять пентоксифиллин одновременно с вышеперечисленными ингибиторами агрегации тромбоцитов (см. раздел «С осторожностью»).\u003Cbr\u003E"},{"name":"Регистрационный номер","value":"П N014229/01"},{"name":"Дата государственной регистрации","value":"12.04.2022"},{"name":"Владелец регистрационного удостоверения","value":"Sanofi","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["34324371:35649313","7893318:11054136"]}}},{"name":"Изготовитель","value":"Zentiva"},{"name":"Фасовщик","value":"Zentiva"},{"name":"Страна бренда","value":"Индия"},{"name":"Страна-производитель","value":"Индия"},{"name":"Название препарата","value":"Трентал","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["17796364:17998875"]}}},{"name":"Срок годности","value":"47 мес."}]}},"fullSpecsGrouped":{"12142622455257747385":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"кровеносная система, кровеносные сосуды"},{"name":"Назначение","value":"лечение и профилактика нарушений мозгового кровообращения, нарушения кровообращения в сетчатке, нарушения кровообращения в сосудистой оболочке глаза, окклюзионная болезнь периферических артерий различного генеза, отосклероз, перемежающаяся хромота, трофические нарушения тканей"},{"name":"Показания к применению","value":"- окклюзионная болезнь периферических артерий атеросклеротического или диабетического генеза (например, \"перемежающаяся\" хромота, диабетическая ангиопатия).\u003Cbr\u003E- трофические нарушения (например, трофические язвы голеней, гангрена).\u003Cbr\u003E- нарушения мозгового кровообращения (последствия церебрального атеросклероза, как, например, снижение концентрации внимания, головокружение, ухудшение памяти), ишемические и постинсультные состояния.\u003Cbr\u003E- нарушения кровообращения в сетчатой и сосудистой оболочке глаза.\u003Cbr\u003E- отосклероз, дегенеративные изменения на фоне патологии сосудов внутреннего уха и снижения слуха.\u003Cbr\u003E"},{"name":"Противопоказания","value":"- повышенная чувствительность к пентоксифиллину, другим метилксантинам или к любому вспомогательному веществу препарата.\u003Cbr\u003E- массивные кровотечения (риск усиления кровотечения).\u003Cbr\u003E- обширные кровоизлияния в сетчатую оболочку глаза (риск усиления кровотечения).\u003Cbr\u003E- кровоизлияния в головной мозг.\u003Cbr\u003E- острый инфаркт миокарда.\u003Cbr\u003E- возраст до 18 лег.\u003Cbr\u003E- беременность (недостаточно данных).\u003Cbr\u003E- период грудного вскармливания (не достаточно данных).\u003Cbr\u003E- непереносимость галактозы, дефицит лактазы и синдром глюкозо-галактозной мальабсорбции (в связи с наличием в составе препарата лактозы).\u003Cbr\u003E"},{"name":"Состав","value":"Ядро:\u003Cbr\u003Eдействующее вещество: пентоксифиллин - 100 мг;\u003Cbr\u003Eвспомогательные вещества: лактоза - 20,00 мг, крахмал - 30,00 мг, тальк - 8,50 мг, кремния диоксид коллоидный - 0,50 мг, магния стеарат - 1,00 мг.\u003Cbr\u003EОболочка: метакриловой кислоты сополимер - 11,45 мг, натрия гидроксид - 0,168 мг, макрогол (полиэтиленгликоль) 8000 - 1,40 мг, тальк - 0,388 мг, титана диоксид (Е 171) - 1,272 мг.\u003Cbr\u003E"},{"name":"Действующее вещество","value":"Пентоксифиллин"},{"name":"Способ применения и дозы","value":"Дозировка устанавливается врачом в соответствии с индивидуальными особенностями больного.\u003Cbr\u003EОбычная доза составляет: одна таблетка Трентала три раза в сутки с последующим медленным повышением дозы до 200 мг 2-3 раза в сутки. Максимальная разовая доза - 400 мг. Максимальная суточная доза - 1200 мг. Препарат следует проглатывать целиком во время или сразу после приема пищи, запивая достаточным количеством воды.\u003Cbr\u003EУ пациентов с нарушенной функцией почек (клиренс креатинина ниже 30 мл/мин) дозировка может быть снижена до 1-2 таблеток в сутки.\u003Cbr\u003EУменьшение дозы, с учетом индивидуальной переносимости, необходимо у пациентов с тяжелым нарушением функции печени.\u003Cbr\u003EЛечение может быть начато малыми дозами у пациентов с низким артериальным давлением, а также у лиц, находящихся в группе риска ввиду возможного снижения артериального давления (пациенты с тяжелой формой ИБС или с гемодинамически значимыми стенозами сосудов головного мозга). В этих случаях доза может быть увеличена только постепенно.\u003Cbr\u003E"},{"name":"Побочные действия","value":"Ниже представлены побочные реакции, которые отмечались в клинических исследованиях и при постмаркетинговом применении препарата (частота неизвестна).\u003Cbr\u003EНарушении со стороны нервной системы: головная боль, головокружение, асептический менингит, судороги.\u003Cbr\u003EНарушения психики: ажитация, нарушения сна, тревога.\u003Cbr\u003EНарушения со стороны сердца: тахикардия, аритмия, снижение артериального давления, стенокардия.\u003Cbr\u003EНарушения со стороны сосудов: \"приливы\" крови к кожным покровам, кровотечения (в том числе, кровотечения из сосудов кожи, слизистых оболочек, желудка, кишечника).\u003Cbr\u003EНарушения со стороны пищеварительной системы: ксеростомия (сухость полости рта), анорексия, атония кишечника, чувство давления и переполнения в области желудка, тошнота, рвота, диарея, запор, гиперсаливация (повышенное слюноотделение).\u003Cbr\u003EНарушения со стороны печени и желчевыводящих путей: внутрипеченочный холестаз, повышение активности \"печеночных\" трансаминаз, повышение активности щелочной фосфатазы.\u003Cbr\u003EНарушении со стороны крови и лимфатической системы: лейкопения/нейтропения, тромбоцитопения, панцитопения, гипофибриногенемия.\u003Cbr\u003EНарушении со стороны органа зрении: нарушение зрения, скотома.\u003Cbr\u003EНарушении со стороны кожи и подкожных тканей: кожный зуд, эритема (покраснение кожи), крапивница, повышенная ломкость ногтей, отеки.\u003Cbr\u003EНарушении со стороны иммунной системы: анафилактические/анафилактоидные реакции, ангионевротический отек, анафилактический шок, бронхоспазм.\u003Cbr\u003E"},{"name":"Фармакологическое действие","value":"Препарат Трентал уменьшает вязкость крови и улучшает реологические свойства крови (текучесть) за счет:\u003Cbr\u003E- улучшения нарушенной деформируемости эритроцитов;\u003Cbr\u003E- уменьшения агрегации тромбоцитов и эритроцитов;\u003Cbr\u003E-снижения концентрации фибриногена;\u003Cbr\u003E- снижения активности лейкоцитов и уменьшения адгезии лейкоцитов к эндотелию сосудов.\u003Cbr\u003EВ качестве активного вещества препарат Трентал содержит производное ксантина - пентоксифиллин. Механизм его действия связан с ингибированием фосфодиэстеразы и накоплением циклического аденозинмонофосфата (цАМФ) в клетках гладкой мускулатуры сосудов и форменных элементах крови.\u003Cbr\u003EОказывая слабое миотропное сосудорасширяющее действие, пентоксифиллин несколько уменьшает общее периферическое сосудистое сопротивление и незначительно расширяет коронарные сосуды.\u003Cbr\u003EПентоксифиллин обладает слабым положительным инотропным эффектом на сердце.\u003Cbr\u003EУлучшает микроциркуляцию в зонах нарушенного кровообращения. Лечение препаратом Трентал приводит к улучшению симптоматики нарушений мозгового кровообращения.\u003Cbr\u003EПри окклюзионных заболеваниях периферических артерий применение препарата Трентал приводит к удлинению дистанции ходьбы, устранению ночных судорог в икроножных мышцах и исчезновению болей в покое.\u003Cbr\u003E"},{"name":"Фармакологическая группа","value":"вазодилататоры"},{"name":"Форма выпуска","value":"таблетки, покрытые кишечнорастворимой оболочкой"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Хранить в сухом месте при температуре не выше 25 С. Хранить в недоступном для детей месте!"},{"name":"Передозировка","value":"Симптомы передози ровки: головокружение, тошнота, рвота типа \"кофейной гущи\", снижение артериального давления, тахикардия, аритмия, покраснение кожных покровов, потеря сознания, озноб, арефлексия, тонико-клонические судороги.\u003Cbr\u003EВ случае возникновения описанных выше нарушений необходимо срочно обратиться к врачу.\u003Cbr\u003EЛечение симптоматическое. При появлении первых признаков передозировки (потливость, тошнота, цианоз) немедленно прекращают прием препарата. Если препарат принят недавно, следует обеспечить меры, направленные на предотвращение дальнейшего всасывания препарата путем его выведения (промывание желудка) или замедления всасывания (например, прием активированного угля).\u003Cbr\u003EОсобое внимание должно быть направлено на поддержание артериального давления и функции дыхания. При судорожных припадках вводят диазепам.\u003Cbr\u003EСпецифический антидот неизвестен.\u003Cbr\u003E"},{"name":"Применение при беременности и кормлении грудью","value":"Беременность\u003Cbr\u003EПрепарат Трентал не рекомендуется к применению при беременности (так как недостаточно данных).\u003Cbr\u003EПериод грудного вскармливания\u003Cbr\u003EПенгоксифиллин проникает в грудное молоко в незначительных количествах.\u003Cbr\u003EПри необходимости применения препарата следует прекратить грудное вскармливание (учитывая отсутствие опыта применения).\u003Cbr\u003E"},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Учитывая возможные побочные эффекты (например, головокружение), следует соблюдать осторожность при вождении автотранспорта и занятиях потенциально опасными видами деятельности.\u003Cbr\u003E"},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EТяжелые нарушения ритма сердца (риск ухудшения аритмии).\u003Cbr\u003EАртериальная гипотензия (риск дальнейшего снижения артериального давления, см. раздел «Способ применения и дозы»).\u003Cbr\u003EХроническая сердечная недостаточность.\u003Cbr\u003EЯзвенная болезнь желудка и двенадцатиперстной кишки.\u003Cbr\u003EНарушения функции почек\u003Cbr\u003EТяжелые нарушения функции печени (риск кумуляции и повышенный риск побочных эффектов, см. раздел «Способ применения и дозы»).\u003Cbr\u003EНедавно перенесенные оперативные вмешательства.\u003Cbr\u003EПовышенный риск развития кровотечений (например, при нарушениях в системе свертывания крови (риск развития более тяжелых кровотечений), см. раздел «Взаимодействие с другими лекарственными средствами»).\u003Cbr\u003EОдновременное применение с антикоагулянтами (в том числе, непрямыми антикоагулянтами [антагонистами, витамина К]) (см. раздел «Взаимодействие с другими лекарственными средствами»).\u003Cbr\u003EОдновременное применение с ингибиторами агрегации тромбоцитов (клопидогрел, эптифибатид, тирофибан, эпопростенол, илопрост, абциксимаб, анагрелид, НПВП [кроме селективных ингибиторов циклооксигеназы-2], ацетилсалициловая кислота, тиклопидин, дипиридамол) (см. раздел «Взаимодействие с другими лекарственными средствами»).\u003Cbr\u003EОдновременное применение с гипогликемическими средствами (инсулином и гипогликемическими средствами для приема внутрь), см. раздел «Взаимодействие с другими лекарственными средствами».\u003Cbr\u003EОдновременное применение с ципрофлоксацином (см. раздел «Взаимодействие с другими лекарственными средствами»).\u003Cbr\u003EОдновременное применение с теофиллином (см. раздел «Взаимодействие с другими лекарственными средствами»).\u003Cbr\u003EОсобые указания:\u003Cbr\u003EЛечение следует проводить под контролем артериального давления.\u003Cbr\u003EУ пациентов с сахарным диабетом, принимающих гипогликемические средства, назначение больших доз может вызвать выраженную гипогликемию (может потребоваться коррекция доз гипогликемических средств и проведение гликемического контроля).\u003Cbr\u003EПри назначении препарата Трентал одновременно с антикоагулянтами необходим контроль показателей свертывающей системы крови.\u003Cbr\u003EУ пациентов, недавно перенесших оперативное вмешательство, необходим регулярный контроль гемоглобина и гематокрита. Пациентам с низким и нестабильным артериальным давлением необходимо уменьшить дозу пентоксифиллина.\u003Cbr\u003EУ пожилых пациентов может потребоваться уменьшение дозы пентоксифиллина (повышение биодоступиости и снижение скорости выведения).\u003Cbr\u003EБезопасность и эффективность пентоксифиллина у детей изучены недостаточно.\u003Cbr\u003EКурение может снижать терапевтическую эффективность препарата.\u003Cbr\u003E"},{"name":"Взаимодействие","value":"С гипотензивными средствами\u003Cbr\u003EПентоксифиллин повышает риск развития артериальной гипотензии при одновременном применении с гипотензивными средсгвам и (например, ингибиторы ангиотензинпревращающего фермента (АПФ)) или другими лекарственными средствами, обладающими потенциальным антигипертензивным эффектом (например, нитраты);\u003Cbr\u003EС лекарственными средствами, влияющими на свертывающую систему крови\u003Cbr\u003EПентоксифиллин может усиливать действие лекарственных средств, влияющих на свертывающую систему крови (прямые и непрямые анти коагулянты, тромболити ки, антибиотики, такие как цефалоспорины).\u003Cbr\u003EПри совместном применении пентоксифиллина и непрямых антикоагулянтов (антагонистов витамина К) в постмаркетинговых исследованиях отмечались случаи усиления антикоагулянтного действия (риск развития кровотечений). Поэтому в начале приема пентоксифиллина или изменении его дозы рекомендуется контролировать степень выраженности антикоагулянтного действия у пациентов, принимающих данную комбинацию препаратов, например, проводить регулярный контроль МНО (международное нормализованное отношение).\u003Cbr\u003EС циметидином\u003Cbr\u003EЦиметидин повышает концентрацию пентоксифиллина и активного метаболита I в плазме крови (риск возникновения побочных реакций).\u003Cbr\u003EС другими ксантинами\u003Cbr\u003EСовместное назначение с другими ксантинами может приводить к чрезмерному нервному возбуждению.\u003Cbr\u003EС гипогликемическими средствами (инсулином и гипогликемическими средствами для приема внутрь)\u003Cbr\u003EГипогликемическое действие инсулина или гипогликемических средств для приема внутрь может усиливаться при одновременном применении пентоксифиллина (повышенный риск развития гипогликемии). Необходим строгий контроль состояния таких пациентов, включая регулярный гликемический контроль.\u003Cbr\u003EС теофиллином\u003Cbr\u003EУ некоторых пациентов при одновременном применении пентоксифиллина и теофиллина отмечается увеличение концентрации теофиллина. В дальнейшем это может приводить к увеличению или усилению побочных действий, связанных с теофиллином.\u003Cbr\u003EС ципрофлоксацином\u003Cbr\u003EУ некоторых пациентов при одновременном применении пентоксифиллина и ципрофлоксацина увеличение концентрации пентоксифиллина в плазме крови. В дальнейшем это может приводить к увеличению или усилению побочных действий, связанных с применением данной комбинации.\u003Cbr\u003EС ингибиторами агрегации тромбоцитов\u003Cbr\u003EПри одновременном применении пентоксифиллина с ингибиторами агрегации тромбоцитов (клопидогрел, эптифибатид, тирофибан, эпопростенол, илопрост, абциксимаб, анагрелид, НПВП [кроме селективных ингибиторов циклооксигеназы-2], ацетилсалициловая кислота, тиклопидин, дипиридамол) возможно развитие потенциального аддитивного действия, увеличивающего риск развития кровотечения. Поэтому из-за риска развития кровотечения следует с осторожностью применять пентоксифиллин одновременно с вышеперечисленными ингибиторами агрегации тромбоцитов (см. раздел «С осторожностью»).\u003Cbr\u003E"},{"name":"Регистрационный номер","value":"П N014229/01"},{"name":"Дата государственной регистрации","value":"12.04.2022"},{"name":"Владелец регистрационного удостоверения","value":"Sanofi"},{"name":"Изготовитель","value":"Zentiva"},{"name":"Фасовщик","value":"Zentiva"},{"name":"Страна бренда","value":"Индия"},{"name":"Страна-производитель","value":"Индия"},{"name":"Название препарата","value":"Трентал"},{"name":"Срок годности","value":"47 мес."}]}],"transitionId":"tr_2930847032285503570"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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816 ₽

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    Цена 1 093 ₽
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  • Пентоксифиллин таб. п/о плен., 100 мг, 60 шт.
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    Пентоксифиллин таб. п/о плен., 100 мг, 60 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 299 ₽
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  • Пентоксифиллин таб. п/о, 100 мг, 60 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-3mp7x10w03l/toggleWishlist":{"skuId":"228063308","productId":1778174063,"offerId":"NNvF7aSsLKlitVp_XRXbMg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ67HEktDG/u5xEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI75DzzwYQzPDfbBii3tAHINfcwQc=","sign":"UIXXZkvQBR6pKAXUOGlkknEL/Jws6sYTTvacrdnrcvg="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-3mp7x10w03l/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Пентоксифиллин таб. п/о, 100 мг, 60 шт.

    Рейтинг товара: 5 из 5
    на основе 6 оценок
    Цена 239 ₽
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  • Пентоксифиллин-СЗ таб. п/о плен. пролонг. высв., 400 мг, 20 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-dde4lya9v36/toggleWishlist":{"skuId":"101392848256","productId":1401075652,"offerId":"bKTBJ21gWn1OMNpx3ruehg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ67HEktDG/u5xEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIxO+KnAUQgKvw2/kCGK7e0Acg19zBBw==","sign":"WKXYMmhsFawaqUJQIAeKK+CmBSdfdw9z8XzUcDNV4AQ="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-dde4lya9v36/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Пентоксифиллин-СЗ таб. п/о плен. пролонг. высв., 400 мг, 20 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 446 ₽
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  • Вазонит таб. пролонг. высвоб. п/о плен., 600 мг, 20 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-go6hxsgcqm/toggleWishlist":{"skuId":"227814105","productId":1778173809,"offerId":"WVeaBpicLSOoG5ROuq9wUA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ67HEktDG/u5xEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI8Y7zzwYQ2dXQbBi61IkRINfcwQc=","sign":"cwNphfAsj59zHX3ZzPmjzEGrMicAeuBjyjQvIsq4vSQ="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-go6hxsgcqm/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Вазонит таб. пролонг. высвоб. п/о плен., 600 мг, 20 шт.

    Рейтинг товара: 4.7 из 5
    на основе 3 оценки
    Цена 682 ₽
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  • Пентоксифиллин таб. п/о кш/раств., 100 мг, 60 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-e0lvl9rx0um/toggleWishlist":{"skuId":"228062768","productId":1778174061,"offerId":"2S6jE7IlGyENuPpPb00e9g","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ67HEktDG/u5xEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI7ZDzzwYQsOzfbBiEqbIIINfcwQc=","sign":"fOjWUj/g2mq01pFmuzSm//tARPWYmZURhdp5kxarksQ="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-e0lvl9rx0um/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Пентоксифиллин таб. п/о кш/раств., 100 мг, 60 шт.

    Рейтинг товара: 4.6 из 5
    на основе 5 оценок
    Цена 368 ₽
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  • Пентоксифиллин ретард таб. п/о плен., 400 мг, 20 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-3r3j4a04mf/toggleWishlist":{"skuId":"186920097","productId":1778173780,"offerId":"Fm1KETpqgwVmDRMWhHHHaA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ67HEktDG/u5xEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI1I7zzwYQodmQWRje3tAHINfcwQc=","sign":"LPMAn8zWtJbZbgSJa3zX7Bh8qCbnTvV2NtIZKn+kEsU="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-3r3j4a04mf/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Пентоксифиллин ретард таб. п/о плен., 400 мг, 20 шт.

    Рейтинг товара: 4.9 из 5
    на основе 12 оценок
    Цена 413 ₽
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  • Пентоксифиллин р-р д/ин. амп., 20 мг/мл, 5 мл, 10 шт.
    –34 %
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    Пентоксифиллин р-р д/ин. амп., 20 мг/мл, 5 мл, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 98 ₽ вместо 148
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  • Пентоксифиллин конц. д/приг. р-ра д/инф. амп., 20 мг/мл, 5 мл, 10 шт.
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    Пентоксифиллин конц. д/приг. р-ра д/инф. амп., 20 мг/мл, 5 мл, 10 шт.

    Рейтинг товара: 4.6 из 5
    на основе 13 оценок
    Цена 239 ₽
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  • Тромбо АСС таб. п/о плен. кш/раств., 100 мг, 100 шт.
    –1 %
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    Тромбо АСС таб. п/о плен. кш/раств., 100 мг, 100 шт.

    Рейтинг товара: 4.9 из 5
    на основе 142 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 149 ₽ вместо 150
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  • Пентоксифиллин р-р д/ин., 20 мг/мл, 5 мл, 10 шт.
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    Пентоксифиллин р-р д/ин., 20 мг/мл, 5 мл, 10 шт.

    Рейтинг товара: 4.4 из 5
    на основе 7 оценок
    Цена 87 ₽
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  • Пентоксифиллин р-р для в/в и в/а введ., 20 мг/мл, 5 мл, 10 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-3g8y2xhp614/toggleWishlist":{"skuId":"101965845843","productId":1823435333,"offerId":"x5BfD-jYpAwwnHrAhCoWpQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ67HEktDG/u5xEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIxdS95QYQ06qN7fsCGJXd0Acg19zBBw==","sign":"2/QsMxzQSjZcbUpBI6drISZHN8UH1IVIQeNOkDU7aKg="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-3g8y2xhp614/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Пентоксифиллин р-р для в/в и в/а введ., 20 мг/мл, 5 мл, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 127 ₽
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Инструкция

Показания к применению

- окклюзионная болезнь периферических артерий атеросклеротического или диабетического генеза (например, "перемежающаяся" хромота, диабетическая ангиопатия).
- трофические нарушения (например, трофические язвы голеней, гангрена).
- нарушения мозгового кровообращения (последствия церебрального атеросклероза, как, например, снижение концентрации внимания, головокружение, ухудшение памяти), ишемические и постинсультные состояния.
- нарушения кровообращения в сетчатой и сосудистой оболочке глаза.
- отосклероз, дегенеративные изменения на фоне патологии сосудов внутреннего уха и снижения слуха.

Противопоказания

- повышенная чувствительность к пентоксифиллину, другим метилксантинам или к любому вспомогательному веществу препарата.
- массивные кровотечения (риск усиления кровотечения).
- обширные кровоизлияния в сетчатую оболочку глаза (риск усиления кровотечения).
- кровоизлияния в головной мозг.
- острый инфаркт миокарда.
- возраст до 18 лег.
- беременность (недостаточно данных).
- период грудного вскармливания (не достаточно данных).
- непереносимость галактозы, дефицит лактазы и синдром глюкозо-галактозной мальабсорбции (в связи с наличием в составе препарата лактозы).

Способ применения и дозы

Дозировка устанавливается врачом в соответствии с индивидуальными особенностями больного.
Обычная доза составляет: одна таблетка Трентала три раза в сутки с последующим медленным повышением дозы до 200 мг 2-3 раза в сутки. Максимальная разовая доза - 400 мг. Максимальная суточная доза - 1200 мг. Препарат следует проглатывать целиком во время или сразу после приема пищи, запивая достаточным количеством воды.
У пациентов с нарушенной функцией почек (клиренс креатинина ниже 30 мл/мин) дозировка может быть снижена до 1-2 таблеток в сутки.
Уменьшение дозы, с учетом индивидуальной переносимости, необходимо у пациентов с тяжелым нарушением функции печени.
Лечение может быть начато малыми дозами у пациентов с низким артериальным давлением, а также у лиц, находящихся в группе риска ввиду возможного снижения артериального давления (пациенты с тяжелой формой ИБС или с гемодинамически значимыми стенозами сосудов головного мозга). В этих случаях доза может быть увеличена только постепенно.
Полная инструкция
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Трентал таб. п/о плен. кш/раств.
Трентал таб. п/о плен. кш/раств., 100 мг, 60 шт.
4.6
(8)
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3 вопроса
Инструкция

816 ₽

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4.6
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У продавца:8 оценок·1 отзыв
У всех продавцов:73 оценки·13 отзывов
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user avatar
8 месяцев назад • Глеб Б. • Куплен на Маркете
Достоинства: отличное лекарство, работает как заявлено, стоит дёшево
Недостатки: есть побочные эффекты, принимать в строго отведённое дозах
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