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Описание

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Ксалатан гл. капли, 0.005%, 2.5 мл, 3 шт.

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4.9
(17)
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Количество штук в упаковке, шт.: 3

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Коротко о товаре

Артикул Маркета
3123923697
Тип препарата
Назначение
Действующее вещество
Возраст
от 1 года
Инструкция
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Оптимальный эффект достигается при применении препарата вечером.\u003Cbr\u003EКак при применении любых глазных капель, с целью снижения возможного системного эффекта препарата, сразу после инстилляции каждой капли рекомендуется надавить на нижнюю слёзную точку, расположенную у внутреннего угла глаза на нижнем веке. Это необходимо делать в течение 1 минуты."},{"name":"Побочные действия","value":"Со стороны органа зрения: раздражение глаз (чувство жжения, ощущение песка в глазах, зуд,\u003Cbr\u003Eпокалывание и ощущение инородного тела); блефарит; гиперемия конъюнктивы; боль в глазах; усиление пигментации радужки; преходящие точечные эрозии эпителия, отек век, периорбитальный отёк, отек и эрозии роговицы; конъюнктивит; удлинение, утолщение, увеличение числа и усиление пигментации ресниц и пушковых волос; ирит/увеит; кератит; макулярный отек, в т.ч. цистоидный; изменение направления роста ресниц, иногда вызывающее раздражение глаза; затуманивание зрения, фотофобия, сухость слизистой оболочки глаз.\u003Cbr\u003EСо стороны кожных покровов и подкожных тканей: сыпь, потемнение кожи век и местные кожные реакции на веках, токсический эпидермальный некролиз.\u003Cbr\u003EСо стороны нервной системы: головокружение, головная боль.\u003Cbr\u003EСо стороны органов дыхания: бронхоспазм (в т.ч. острые приступы или обострение заболевания у пациентов с бронхиальной астмой в анамнезе), одышка.\u003Cbr\u003EСо стороны опорно-двигательного аппарата и соединительной ткани: боли в мышцах/суставах.\u003Cbr\u003EОбщие и местные реакции: неспецифические боли в груди.\u003Cbr\u003EИнфекции и инвазии: герпетический кератит.\u003Cbr\u003EТакже отмечались случаи эмболии артерии сетчатки, отслойка сетчатки и кровоизлияние в\u003Cbr\u003Eстекловидное тело у пациентов с диабетической ретинопатией.\u003Cbr\u003EДети\u003Cbr\u003EПрофиль безопасности препарата у детей не отличался от профиля безопасности у\u003Cbr\u003Eвзрослых. По сравнению со взрослой популяцией, у детей наиболее часто отмечались назофарингит и лихорадка."},{"name":"Фармакологическое действие","value":"Латанопрост - аналог простагландина F2α - является селективным агонистом рецепторов FP (простагландина F) и снижает внутриглазное давление (ВГД) за счет увеличения оттока водянистой влаги, главным образом, увеосклеральным путем, а также через трабекулярную сеть.\u003Cbr\u003EСнижение ВГД начинается приблизительно через 3-4 ч после введения препарата, максимальный эффект наблюдается через 8-12 ч, действие сохраняется в течение не менее 24 ч.\u003Cbr\u003EИсследования на животных и у человека показали, что основным механизмом действия является увеличение увеосклерального оттока, кроме того, у человека также описано улучшение оттока (снижение сопротивления оттоку).\u003Cbr\u003EИсследования на животных показали, что в клинических дозах латанопрост не влияет (или влияет незначимо) на внутриглазное кровообращение. При местном применении возможны конъюнктивальная или эписклеральная инъекция легкой или средней степени выраженности. По данным флюоресцентной ангиографии длительное, лечение латанопростом после экстракапсулярной экстракции катаракты у обезьян не оказывала влияния на кровообращение сетчатки.\u003Cbr\u003EПри краткосрочном применений латанопрост не способствовал просачиванию флуоресцеина в заднем сегменте глаза пациентов с искусственным хрусталиком.\u003Cbr\u003EУстановлено, что латанопрост не оказывает существенного влияния на продукцию водянистой влаги и на гематрофтальмический барьер.\u003Cbr\u003EПри применении в терапевтических дозах латанопрост не оказывает значимого фармакологического эффекта на сердечно-сосудистую и дыхательную системы.\u003Cbr\u003EДети\u003Cbr\u003EЭффективность препарата Ксалатан у детей в возрасте младше 18 лет была показана в 12-недельном двойном слепом исследовании латанопроста в сравнении с тимололом у 107 пациентов с диагнозом интраокулярная гипертензия и инфантильная глаукома.\u003Cbr\u003EСнижение внутриглазного давления у пациентов основной подгруппы с первичной врожденной/инфантильной глаукомой было сопоставимым между группой пациентов, получающих латанопрост и группой, получающей тимолол.\u003Cbr\u003EУ пациентов с не первично врожденными формами глаукомы (например, ювенильная открытоугольная глаукома, афакическая глаукома) отмечались такие же результаты, как и у группы с первичной врожденной глаукомой.\u003Cbr\u003EВлияние на внутриглазное давление отмечали после первой недели терапии и оно сохранялось в течение 12 недельного периода исследования, как и у взрослых пациентов.\u003Cbr\u003EДанные о влиянии латанопроста на внутриглазное давление у детей в возрасте младше 36 недель отсутствуют."},{"name":"Фармакологическая группа","value":"противоглаукомное средство (простагландина F2-альфа аналог синтетический)"},{"name":"Форма выпуска","value":"капли"},{"name":"Способ применения/введения","value":"конъюктивальный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["35947170:36763746"]}}},{"name":"Минимальный возраст применения","value":"от 1 года"},{"name":"Условия хранения","value":"При температуре + 2 - + 8 °С, в защищенном от света месте.\u003Cbr\u003EВскрытый флакон хранить при температуре не выше + 25 °С."},{"name":"Передозировка","value":"В случае передозировки проводят симптоматическое лечение.\u003Cbr\u003EПомимо раздражения слизистой оболочки глаз, гиперемии конъюнктивы или эписклеры, других нежелательных изменений со стороны органа зрения при передозировке латанопроста не известны.\u003Cbr\u003EПри случайном приеме латанопроста внутрь следует учитывать следующую информацию: один флакон с 2,5 мл раствора содержит 125 мкг латанопроста. Более 90% препарата метаболизируется при первом прохождении через печень. Внутривенное введение латанопроста обезьянам в дозе 500 мкг/кг не вызывало значимых эффектов со стороны сердечно-сосудистой системы. Внутривенное введение латанопроста обезьянам вызывало преходящий бронхоспазм. Внутривенная инфузия в дозе 3 мкг/кг у здоровых добровольцев не вызывала каких-либо симптомов, однако при введении дозы 5,5-10 мкг/кг наблюдались тошнота, боль в животе, головокружение, утомляемость, приливы, и потливость.\u003Cbr\u003EУ больных бронхиальной астмой средней степени тяжести введение латанапроста в глаза в дозе, в 7 раз превышающей терапевтическую не вызывало бронхоспазма."},{"name":"Применение при беременности и кормлении грудью","value":"Адекватных контролируемых исследований у беременных женщин не проводились. Препарат следует назначать при беременности только в тех случаях, когда потенциальная польза для матери превышает возможный риск для плода.\u003Cbr\u003EЛатанопрост и его метаболиты могут выделяться в грудное молоко, поэтому в период кормления грудью препарат следует применять с осторожностью.\u003Cbr\u003E"},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Как и при применении других офтальмологических лекарственных препаратов, возможно временное нарушение зрения; до его восстановления управлять транспортными средствами или работать с механизмами не рекомендуется."},{"name":"Особые указания","value":"Латанопрост может постепенно изменить цвет глаз за счет увеличения содержания коричневого пигмента в радужке. До начала лечения пациентов следует проинформировать о возможном необратимом изменении цвета глаз. Применение лекарственного препарата на одном глазу может вызвать необратимую гетерохромию.\u003Cbr\u003EТакое изменение цвета глаз преимущественно отмечалось у пациентов с неравномерно окрашенными радужками, а именно: каре-голубыми, серо-карими, желто-карими и зелено-карими. В исследованиях латанопроста потемнение, как правило, начиналось в течение первых 8 месяцев лечения, редко - в течение второго или третьего года и не отмечалось по истечении четырех лет лечения.\u003Cbr\u003EПрогрессирование пигментации радужки снижалось со временем и стабилизировалось через 5 лет. Данные об усилении пигментации в течение 5 лет отсутствуют. В открытом 5-летнем исследовании безопасности латанопроста у 33% пациентов развивалась пигментация радужки (см. раздел \"Побочное действие\"). В большинстве случаев изменение цвета радужки было незначительным и, зачастую, клинически не выявлялось. Частота встречаемости колебалась от 7 до 85% у пациентов с неодинакового цвета радужками, преобладая у пациентов с желто-карими радужками. Изменения у пациентов с равномерно окрашенными радужками голубого цвета не наблюдались, в редких случаях изменения отмечались при равномерно окрашенных радужках серого, зеленого и карего цвета.\u003Cbr\u003EИзменение цвета глаз обусловлено увеличением содержания меланина в стромальных меланоцитах радужки, а не увеличением числа самих меланоцитов. В типичных случаях коричневая пигментация появляется вокруг зрачка и концентрически распространяется на периферию радужки. При этом вся радужка или ее части приобретают карий цвет. После отмены терапии дальнейшая пигментация не отмечалась. По имеющимся клиническим данным изменение цвета не было связано с какими либо симптомами или патологическими нарушениями.\u003Cbr\u003EПрепарат не оказывает влияния на невусы и лентиго радужной оболочки. Согласно результатам 5-летних клинических исследований, накопления пигмента в склеро-роговичной трабекулярной сети или иных отделах передней камеры глаза не отмечено. Показано, что потемнение радужки не приводит к нежелательным клиническим последствиям, поэтому применение латанопроста при возникновении такого потемнения можно продолжить. Тем не менее такие пациенты должны находиться под регулярным наблюдением и, в зависимости от клинической ситуации, лечение может быть прекращено.\u003Cbr\u003EОпыт применения латанопроста в терапии закрытоугольной и врожденной глаукомы, пигментной глаукомы, открытоугольной глаукомы у пациентов с псевдоафакией ограничен.\u003Cbr\u003EОтсутствуют сведения о применении латанопроста в лечении вторичной глаукомы вследствие воспалительных заболеваний глаз и неоваскулярной глаукомы.\u003Cbr\u003EЛатанопрост не оказывает влияния на величину зрачка. В связи с отсутствием опыта применения латанопроста в терапии острого приступа закрытоугольной глаукомы, следует с осторожностью применять препарат у таких пациентов.\u003Cbr\u003EВ связи с тем, что сведения о применении латанопроста в послеоперационном периоде экстракции катаракты ограничены, следует соблюдать осторожность при применении препарата у этой категории пациентов.\u003Cbr\u003EСледует соблюдать осторожность при применении латанопроста пациентами с герпетическим кератитом в анамнезе. При остром герпетическом кератите, а также в случае наличия анамнестических сведений о хроническом рецидивирующем герпетическом кератите, необходимо избегать назначения латанопроста.\u003Cbr\u003EМакулярный отек, в том числе кистозный, отмечался в период терапии латанопростом преимущественно у пациентов с афакией, псевдоафакией, разрывом задней капсулы хрусталика, или у пациентов с факторами риска развития кистозного макулярного отека (в частности, при диабетической ретинопатии и окклюзии вен сетчатки). Следует соблюдать осторожность при применении латанопроста пациентами с афакией, псевдоафакией с разрывом задней капсулы или переднекамерными интраокулярными линзами, а также пациентами с известными факторами риска кистозного отека макулы.\u003Cbr\u003EСледует соблюдать осторожность при применении латанопроста пациентами с факторами риска развития ирита/увеита.\u003Cbr\u003EОпыт применения латанопроста пациентами с бронхиальной астмой ограничен, но в ряде случаев в пострегистрационном периоде отмечались обострение течения астмы и/или появление одышки. Следует соблюдать осторожность при применении латанопроста у этой категории пациентов (см. также раздел \"Побочное действие\").\u003Cbr\u003EОтмечались случаи потемнения кожи периорбитальной области, которые у ряда пациентов носили обратимый характер при продолжении терапии латанопростом.\u003Cbr\u003EЛатанопрост может вызывать постепенные изменения ресниц и пушковых волос, такие как удлинение, утолщение, усиление пигментации, увеличение густоты и изменение направления роста ресниц. Изменения ресниц были обратимы и проходили после прекращения терапии.\u003Cbr\u003EКсалатан содержит бензалкония хлорид, часто используемый в качестве консерванта в офтальмологических лекарственных препаратах.\u003Cbr\u003EБензалкония хлорид может вызывать раздражение глаз, точечную кератопатию и/или токсическую язвенную кератопатию, а также абсорбироваться мягкими контактными линзами и обесцвечивать их.\u003Cbr\u003EТребуется тщательный мониторинг состояния пациентов с синдромом \"сухого\" глаза или других заболеваний роговицы при длительном применении латанопроста. Перед применением препарата необходимо снять контактные линзы и снова установить их не ранее чем через 15 минут после инстилляции (см. также раздел \"Способ применения и дозы\").\u003Cbr\u003EДети\u003Cbr\u003EСведения об эффективности и безопасности применения латанопроста у детей младше года ограничены. Отсутствует опыт применения препарата у недоношенных детей (гестационный возраст менее 36 недель).\u003Cbr\u003EСведения о безопасности долгосрочного применения латанопроста у детей отсутствуют.\u003Cbr\u003EПри первичной врожденной глаукоме у детей от 0 до 3 лет стандартным методом лечения остается хирургическое вмешательство (гониотомия/трабекулотомия)."},{"name":"Взаимодействие","value":"При одновременном закапывании в глаза двух аналогов простагландинов описано парадоксальное повышение ВГД, поэтому одновременное применение двух и более простагландинов, их аналогов или производных не рекомендуется.\u003Cbr\u003EФармацевтически несовместим с глазными каплями, содержащими тиомерсал – преципитация."},{"name":"Регистрационный номер","value":"П N012867/01"},{"name":"Дата государственной регистрации","value":"28.08.2019"},{"name":"Владелец регистрационного удостоверения","value":"Pfizer","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["34324371:35649313","7893318:12782011"]}}},{"name":"Изготовитель","value":"Pfizer MFG. Belgium N.V."},{"name":"Фасовщик","value":"Pfizer MFG. Belgium N.V."},{"name":"Страна бренда","value":"США"},{"name":"Страна-производитель","value":"Бельгия"},{"name":"Название препарата","value":"Ксалатан","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["17796364:18046473"]}}},{"name":"Срок годности","value":"35 мес."}]}},"fullSpecsGrouped":{"12162183344703466680":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"глаза"},{"name":"Назначение","value":"открытоугольная глаукома, повышение внутриглазного давления"},{"name":"Показания к применению","value":"Снижение повышенного внутриглазного давления (ВГД) у взрослых и детей (в возрасте старше 1 года) с открытоугольной глаукомой или повышенным офтальмотонусом."},{"name":"Противопоказания","value":"Повышенная чувствительность к латанопросту или другим компонентам препарата.\u003Cbr\u003EВозраст до 1 года (эффективность и безопасность не установлены)."},{"name":"Состав","value":"1 мл раствора содержит:\u003Cbr\u003Eактивное вещество: латанопрост - 50 мкг;\u003Cbr\u003Eвспомогательные вещества: натрия хлорид, натрия дигидрофосфат (моногидрат), натрия гидрофосфат (безводный), бензалкония хлорид, вода для инъекций."},{"name":"Действующее вещество","value":"Латанопрост"},{"name":"Способ применения и дозы","value":"У взрослых и детей старше 1 года - по одной капле в пораженный глаз(а) один раз в день. Оптимальный эффект достигается при применении препарата вечером.\u003Cbr\u003EКак при применении любых глазных капель, с целью снижения возможного системного эффекта препарата, сразу после инстилляции каждой капли рекомендуется надавить на нижнюю слёзную точку, расположенную у внутреннего угла глаза на нижнем веке. Это необходимо делать в течение 1 минуты."},{"name":"Побочные действия","value":"Со стороны органа зрения: раздражение глаз (чувство жжения, ощущение песка в глазах, зуд,\u003Cbr\u003Eпокалывание и ощущение инородного тела); блефарит; гиперемия конъюнктивы; боль в глазах; усиление пигментации радужки; преходящие точечные эрозии эпителия, отек век, периорбитальный отёк, отек и эрозии роговицы; конъюнктивит; удлинение, утолщение, увеличение числа и усиление пигментации ресниц и пушковых волос; ирит/увеит; кератит; макулярный отек, в т.ч. цистоидный; изменение направления роста ресниц, иногда вызывающее раздражение глаза; затуманивание зрения, фотофобия, сухость слизистой оболочки глаз.\u003Cbr\u003EСо стороны кожных покровов и подкожных тканей: сыпь, потемнение кожи век и местные кожные реакции на веках, токсический эпидермальный некролиз.\u003Cbr\u003EСо стороны нервной системы: головокружение, головная боль.\u003Cbr\u003EСо стороны органов дыхания: бронхоспазм (в т.ч. острые приступы или обострение заболевания у пациентов с бронхиальной астмой в анамнезе), одышка.\u003Cbr\u003EСо стороны опорно-двигательного аппарата и соединительной ткани: боли в мышцах/суставах.\u003Cbr\u003EОбщие и местные реакции: неспецифические боли в груди.\u003Cbr\u003EИнфекции и инвазии: герпетический кератит.\u003Cbr\u003EТакже отмечались случаи эмболии артерии сетчатки, отслойка сетчатки и кровоизлияние в\u003Cbr\u003Eстекловидное тело у пациентов с диабетической ретинопатией.\u003Cbr\u003EДети\u003Cbr\u003EПрофиль безопасности препарата у детей не отличался от профиля безопасности у\u003Cbr\u003Eвзрослых. По сравнению со взрослой популяцией, у детей наиболее часто отмечались назофарингит и лихорадка."},{"name":"Фармакологическое действие","value":"Латанопрост - аналог простагландина F2α - является селективным агонистом рецепторов FP (простагландина F) и снижает внутриглазное давление (ВГД) за счет увеличения оттока водянистой влаги, главным образом, увеосклеральным путем, а также через трабекулярную сеть.\u003Cbr\u003EСнижение ВГД начинается приблизительно через 3-4 ч после введения препарата, максимальный эффект наблюдается через 8-12 ч, действие сохраняется в течение не менее 24 ч.\u003Cbr\u003EИсследования на животных и у человека показали, что основным механизмом действия является увеличение увеосклерального оттока, кроме того, у человека также описано улучшение оттока (снижение сопротивления оттоку).\u003Cbr\u003EИсследования на животных показали, что в клинических дозах латанопрост не влияет (или влияет незначимо) на внутриглазное кровообращение. При местном применении возможны конъюнктивальная или эписклеральная инъекция легкой или средней степени выраженности. По данным флюоресцентной ангиографии длительное, лечение латанопростом после экстракапсулярной экстракции катаракты у обезьян не оказывала влияния на кровообращение сетчатки.\u003Cbr\u003EПри краткосрочном применений латанопрост не способствовал просачиванию флуоресцеина в заднем сегменте глаза пациентов с искусственным хрусталиком.\u003Cbr\u003EУстановлено, что латанопрост не оказывает существенного влияния на продукцию водянистой влаги и на гематрофтальмический барьер.\u003Cbr\u003EПри применении в терапевтических дозах латанопрост не оказывает значимого фармакологического эффекта на сердечно-сосудистую и дыхательную системы.\u003Cbr\u003EДети\u003Cbr\u003EЭффективность препарата Ксалатан у детей в возрасте младше 18 лет была показана в 12-недельном двойном слепом исследовании латанопроста в сравнении с тимололом у 107 пациентов с диагнозом интраокулярная гипертензия и инфантильная глаукома.\u003Cbr\u003EСнижение внутриглазного давления у пациентов основной подгруппы с первичной врожденной/инфантильной глаукомой было сопоставимым между группой пациентов, получающих латанопрост и группой, получающей тимолол.\u003Cbr\u003EУ пациентов с не первично врожденными формами глаукомы (например, ювенильная открытоугольная глаукома, афакическая глаукома) отмечались такие же результаты, как и у группы с первичной врожденной глаукомой.\u003Cbr\u003EВлияние на внутриглазное давление отмечали после первой недели терапии и оно сохранялось в течение 12 недельного периода исследования, как и у взрослых пациентов.\u003Cbr\u003EДанные о влиянии латанопроста на внутриглазное давление у детей в возрасте младше 36 недель отсутствуют."},{"name":"Фармакологическая группа","value":"противоглаукомное средство (простагландина F2-альфа аналог синтетический)"},{"name":"Форма выпуска","value":"капли"},{"name":"Способ применения/введения","value":"конъюктивальный"},{"name":"Минимальный возраст применения","value":"от 1 года"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"При температуре + 2 - + 8 °С, в защищенном от света месте.\u003Cbr\u003EВскрытый флакон хранить при температуре не выше + 25 °С."},{"name":"Передозировка","value":"В случае передозировки проводят симптоматическое лечение.\u003Cbr\u003EПомимо раздражения слизистой оболочки глаз, гиперемии конъюнктивы или эписклеры, других нежелательных изменений со стороны органа зрения при передозировке латанопроста не известны.\u003Cbr\u003EПри случайном приеме латанопроста внутрь следует учитывать следующую информацию: один флакон с 2,5 мл раствора содержит 125 мкг латанопроста. Более 90% препарата метаболизируется при первом прохождении через печень. Внутривенное введение латанопроста обезьянам в дозе 500 мкг/кг не вызывало значимых эффектов со стороны сердечно-сосудистой системы. Внутривенное введение латанопроста обезьянам вызывало преходящий бронхоспазм. Внутривенная инфузия в дозе 3 мкг/кг у здоровых добровольцев не вызывала каких-либо симптомов, однако при введении дозы 5,5-10 мкг/кг наблюдались тошнота, боль в животе, головокружение, утомляемость, приливы, и потливость.\u003Cbr\u003EУ больных бронхиальной астмой средней степени тяжести введение латанапроста в глаза в дозе, в 7 раз превышающей терапевтическую не вызывало бронхоспазма."},{"name":"Применение при беременности и кормлении грудью","value":"Адекватных контролируемых исследований у беременных женщин не проводились. Препарат следует назначать при беременности только в тех случаях, когда потенциальная польза для матери превышает возможный риск для плода.\u003Cbr\u003EЛатанопрост и его метаболиты могут выделяться в грудное молоко, поэтому в период кормления грудью препарат следует применять с осторожностью.\u003Cbr\u003E"},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Как и при применении других офтальмологических лекарственных препаратов, возможно временное нарушение зрения; до его восстановления управлять транспортными средствами или работать с механизмами не рекомендуется."},{"name":"Особые указания","value":"Латанопрост может постепенно изменить цвет глаз за счет увеличения содержания коричневого пигмента в радужке. До начала лечения пациентов следует проинформировать о возможном необратимом изменении цвета глаз. Применение лекарственного препарата на одном глазу может вызвать необратимую гетерохромию.\u003Cbr\u003EТакое изменение цвета глаз преимущественно отмечалось у пациентов с неравномерно окрашенными радужками, а именно: каре-голубыми, серо-карими, желто-карими и зелено-карими. В исследованиях латанопроста потемнение, как правило, начиналось в течение первых 8 месяцев лечения, редко - в течение второго или третьего года и не отмечалось по истечении четырех лет лечения.\u003Cbr\u003EПрогрессирование пигментации радужки снижалось со временем и стабилизировалось через 5 лет. Данные об усилении пигментации в течение 5 лет отсутствуют. В открытом 5-летнем исследовании безопасности латанопроста у 33% пациентов развивалась пигментация радужки (см. раздел \"Побочное действие\"). В большинстве случаев изменение цвета радужки было незначительным и, зачастую, клинически не выявлялось. Частота встречаемости колебалась от 7 до 85% у пациентов с неодинакового цвета радужками, преобладая у пациентов с желто-карими радужками. Изменения у пациентов с равномерно окрашенными радужками голубого цвета не наблюдались, в редких случаях изменения отмечались при равномерно окрашенных радужках серого, зеленого и карего цвета.\u003Cbr\u003EИзменение цвета глаз обусловлено увеличением содержания меланина в стромальных меланоцитах радужки, а не увеличением числа самих меланоцитов. В типичных случаях коричневая пигментация появляется вокруг зрачка и концентрически распространяется на периферию радужки. При этом вся радужка или ее части приобретают карий цвет. После отмены терапии дальнейшая пигментация не отмечалась. По имеющимся клиническим данным изменение цвета не было связано с какими либо симптомами или патологическими нарушениями.\u003Cbr\u003EПрепарат не оказывает влияния на невусы и лентиго радужной оболочки. Согласно результатам 5-летних клинических исследований, накопления пигмента в склеро-роговичной трабекулярной сети или иных отделах передней камеры глаза не отмечено. Показано, что потемнение радужки не приводит к нежелательным клиническим последствиям, поэтому применение латанопроста при возникновении такого потемнения можно продолжить. Тем не менее такие пациенты должны находиться под регулярным наблюдением и, в зависимости от клинической ситуации, лечение может быть прекращено.\u003Cbr\u003EОпыт применения латанопроста в терапии закрытоугольной и врожденной глаукомы, пигментной глаукомы, открытоугольной глаукомы у пациентов с псевдоафакией ограничен.\u003Cbr\u003EОтсутствуют сведения о применении латанопроста в лечении вторичной глаукомы вследствие воспалительных заболеваний глаз и неоваскулярной глаукомы.\u003Cbr\u003EЛатанопрост не оказывает влияния на величину зрачка. В связи с отсутствием опыта применения латанопроста в терапии острого приступа закрытоугольной глаукомы, следует с осторожностью применять препарат у таких пациентов.\u003Cbr\u003EВ связи с тем, что сведения о применении латанопроста в послеоперационном периоде экстракции катаракты ограничены, следует соблюдать осторожность при применении препарата у этой категории пациентов.\u003Cbr\u003EСледует соблюдать осторожность при применении латанопроста пациентами с герпетическим кератитом в анамнезе. При остром герпетическом кератите, а также в случае наличия анамнестических сведений о хроническом рецидивирующем герпетическом кератите, необходимо избегать назначения латанопроста.\u003Cbr\u003EМакулярный отек, в том числе кистозный, отмечался в период терапии латанопростом преимущественно у пациентов с афакией, псевдоафакией, разрывом задней капсулы хрусталика, или у пациентов с факторами риска развития кистозного макулярного отека (в частности, при диабетической ретинопатии и окклюзии вен сетчатки). Следует соблюдать осторожность при применении латанопроста пациентами с афакией, псевдоафакией с разрывом задней капсулы или переднекамерными интраокулярными линзами, а также пациентами с известными факторами риска кистозного отека макулы.\u003Cbr\u003EСледует соблюдать осторожность при применении латанопроста пациентами с факторами риска развития ирита/увеита.\u003Cbr\u003EОпыт применения латанопроста пациентами с бронхиальной астмой ограничен, но в ряде случаев в пострегистрационном периоде отмечались обострение течения астмы и/или появление одышки. Следует соблюдать осторожность при применении латанопроста у этой категории пациентов (см. также раздел \"Побочное действие\").\u003Cbr\u003EОтмечались случаи потемнения кожи периорбитальной области, которые у ряда пациентов носили обратимый характер при продолжении терапии латанопростом.\u003Cbr\u003EЛатанопрост может вызывать постепенные изменения ресниц и пушковых волос, такие как удлинение, утолщение, усиление пигментации, увеличение густоты и изменение направления роста ресниц. Изменения ресниц были обратимы и проходили после прекращения терапии.\u003Cbr\u003EКсалатан содержит бензалкония хлорид, часто используемый в качестве консерванта в офтальмологических лекарственных препаратах.\u003Cbr\u003EБензалкония хлорид может вызывать раздражение глаз, точечную кератопатию и/или токсическую язвенную кератопатию, а также абсорбироваться мягкими контактными линзами и обесцвечивать их.\u003Cbr\u003EТребуется тщательный мониторинг состояния пациентов с синдромом \"сухого\" глаза или других заболеваний роговицы при длительном применении латанопроста. Перед применением препарата необходимо снять контактные линзы и снова установить их не ранее чем через 15 минут после инстилляции (см. также раздел \"Способ применения и дозы\").\u003Cbr\u003EДети\u003Cbr\u003EСведения об эффективности и безопасности применения латанопроста у детей младше года ограничены. Отсутствует опыт применения препарата у недоношенных детей (гестационный возраст менее 36 недель).\u003Cbr\u003EСведения о безопасности долгосрочного применения латанопроста у детей отсутствуют.\u003Cbr\u003EПри первичной врожденной глаукоме у детей от 0 до 3 лет стандартным методом лечения остается хирургическое вмешательство (гониотомия/трабекулотомия)."},{"name":"Взаимодействие","value":"При одновременном закапывании в глаза двух аналогов простагландинов описано парадоксальное повышение ВГД, поэтому одновременное применение двух и более простагландинов, их аналогов или производных не рекомендуется.\u003Cbr\u003EФармацевтически несовместим с глазными каплями, содержащими тиомерсал – преципитация."},{"name":"Регистрационный номер","value":"П N012867/01"},{"name":"Дата государственной регистрации","value":"28.08.2019"},{"name":"Владелец регистрационного удостоверения","value":"Pfizer"},{"name":"Изготовитель","value":"Pfizer MFG. Belgium N.V."},{"name":"Фасовщик","value":"Pfizer MFG. Belgium N.V."},{"name":"Страна бренда","value":"США"},{"name":"Страна-производитель","value":"Бельгия"},{"name":"Название препарата","value":"Ксалатан"},{"name":"Срок годности","value":"35 мес."}]}],"transitionId":"tr_14015659959702642998"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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    Цена 801 ₽
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  • Латанопрост-Оптик гл. капли фл., 0.005%, 2.5 мл
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    Латанопрост-Оптик гл. капли фл., 0.005%, 2.5 мл

    Рейтинг товара: 5 из 5
    на основе 4 оценки
    Цена 356 ₽
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  • Ксалаком гл. капли, 2.5 мл, 1 шт.
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    Ксалаком гл. капли, 2.5 мл, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 1 169 ₽
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  • Дорзопт гл. капли, 2%, 5 мл, 1 шт.
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    Дорзопт гл. капли, 2%, 5 мл, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 5 оценок
    Цена 338 ₽
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  • Пролатан гл. капли, 0.005%, 2.5 мл, 1 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-m9scoywwrg/toggleWishlist":{"skuId":"228007973","productId":1417729429,"offerId":"XICdwZEKcc_X3sLgDu4lEg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQkqqDuN/v241DEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIlauDpAUQpcDcbBjovt4HINzcwQc=","sign":"zLXYv+lK/zUBE8GXhCgm5/ybZcfWe0cKmNzegnWZ3dU="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-m9scoywwrg/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Пролатан гл. капли, 0.005%, 2.5 мл, 1 шт.

    Рейтинг товара: 4.5 из 5
    на основе 2 оценки
    Цена 691 ₽
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  • Азарга гл. капли фл.-капельница, 10 мг/мл+5 мг/мл, 5 мл
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    Азарга гл. капли фл.-капельница, 10 мг/мл+5 мг/мл, 5 мл

    Рейтинг товара: 5 из 5
    на основе 5 оценок
    Цена 1 269 ₽
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  • Глаупрост гл. капли, 0.005%, 2.5 мл, 1 шт.
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    Глаупрост гл. капли, 0.005%, 2.5 мл, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 851 ₽
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  • Альфаган Р гл.капли фл.-капельница, 0.15%, 5 мл, 1 шт.
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    Альфаган Р гл.капли фл.-капельница, 0.15%, 5 мл, 1 шт.

    Рейтинг товара: 4.6 из 5
    на основе 5 оценок
    Цена 987 ₽
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  • Каталин таб. д/приг. гл. капель, 0.75 мг, 15 мл, 1 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-vm463axgr9/toggleWishlist":{"skuId":"101485582743","productId":334549471,"offerId":"FWirRbS4bc1oc2rR1j5OpQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQkqqDuN/v241DEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI36PDnwEQl7OMiPoCGIaj2Qcg3NzBBw==","sign":"bcIxyL26HtQqrMNMc37tO9v9O43FcAdHgnydBnPrfBY="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-vm463axgr9/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Каталин таб. д/приг. гл. капель, 0.75 мг, 15 мл, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 618 ₽
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  • Глаумакс гл. капли, 0.005%, 2.5 мл, 1 шт.
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    Глаумакс гл. капли, 0.005%, 2.5 мл, 1 шт.

    Рейтинг товара: 4.3 из 5
    на основе 12 оценок
    Цена 524 ₽
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  • Дорзопт Плюс гл. капли фл.-капельница, 20 мг/мл+5 мг/мл, 5 мл, 1 шт.
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    Дорзопт Плюс гл. капли фл.-капельница, 20 мг/мл+5 мг/мл, 5 мл, 1 шт.

    Рейтинг товара: 4.9 из 5
    на основе 9 оценок
    Цена 1 064 ₽
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  • Isotine гл. капли фл.-капельница, 10 мл, 10 мл, 20 г, 1 шт.
    –22 %
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    Isotine гл. капли фл.-капельница, 10 мл, 10 мл, 20 г, 1 шт.

    Рейтинг товара: 4.6 из 5
    на основе 113 оценок
    Цена 305 ₽ вместо 390
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Инструкция

Показания к применению

Снижение повышенного внутриглазного давления (ВГД) у взрослых и детей (в возрасте старше 1 года) с открытоугольной глаукомой или повышенным офтальмотонусом.

Противопоказания

Повышенная чувствительность к латанопросту или другим компонентам препарата.
Возраст до 1 года (эффективность и безопасность не установлены).

Способ применения и дозы

У взрослых и детей старше 1 года - по одной капле в пораженный глаз(а) один раз в день. Оптимальный эффект достигается при применении препарата вечером.
Как при применении любых глазных капель, с целью снижения возможного системного эффекта препарата, сразу после инстилляции каждой капли рекомендуется надавить на нижнюю слёзную точку, расположенную у внутреннего угла глаза на нижнем веке. Это необходимо делать в течение 1 минуты.
Полная инструкция
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Ксалатан гл. капли
Ксалатан гл. капли, 0.005%, 2.5 мл, 3 шт.
4.9
(17)
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11 вопросов
Инструкция

2 079 ₽

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4.9
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У продавца:17 оценок·5 отзывов
У всех продавцов:110 оценок·29 отзывов
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user avatar
6 месяцев назад • Сергей Ш. • Куплен на Маркете
Достоинства: Незаменимые капли при глаукоме
Недостатки: Нет
Комментарий: В семье пользуются двое этими каплями. Удобная упаковка по три флакончика. Хороший срок годности до 2026 года
user avatar
5 месяцев назад • Елена Телегина • Куплен на Маркете
Достоинства: Цена чуть ниже, чем в других аптеках.
Недостатки: НЕТ недостатков!
Комментарий: Если ещё будет чуть дешевле, товар будет "улетать".
user avatar
5 месяцев назад • Ольга Якшина • Куплен на Маркете
Достоинства: Удобно в использовании
Недостатки: Нет
Комментарий: Снимает глазное давление великолепно
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