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Описание

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Энкорат Хроно таб. п/о плен. пролонг. высв., 500 мг, 30 шт.

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5.0
(13)
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Дозировка: 500 мг

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Коротко о товаре

Артикул Маркета
3945021050
Тип препарата
Назначение
Действующее вещество
Возраст
от 3 лет
Инструкция
{"widgets":{"@card/SpecsList":{"/content/page/fancyPage/productSpecsList":{"wrapperProps":{"margins":{"top":4,"bottom":4}},"specsLimit":5,"title":"Коротко о товаре","titleSize":"14","type":"minimal","offset":"s","isHealthCategory":true,"forceShowWidget":true,"withFridge":true}}},"meta":{"/content/page/fancyPage/productSpecsList":{"name":"@card/SpecsList"}},"collections":{"minimalSpecs":{"16786562083799840517":{"specItems":[{"name":"Артикул Маркета","value":"3945021050","withCopyValueButton":true},{"name":"тип препарата","value":"рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"назначение","value":"эпилепсия","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["36476390:36618705"]}}},{"name":"действующее вещество","value":"Вальпроевая кислота","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["27144131:28708990"]}}},{"name":"возраст","value":"от 3 лет"},{"name":"форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"страна-производитель","value":"Индия"}]}},"compactSpecs":{"16786562083799840517":{"specItems":[{"name":"Артикул Маркета","value":"3945021050","withCopyValueButton":true},{"name":"Тип препарата","value":"Рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"Назначение","value":"Эпилепсия","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["36476390:36618705"]}}},{"name":"Действующее вещество","value":"Вальпроевая кислота","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["27144131:28708990"]}}},{"name":"Возраст","value":"От 3 лет"}]}},"fullSpecs":{"16786562083799840517":{"specItems":[{"name":"Тип препарата","value":"лекарственный препарат","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["34324371:35649313"]}}},{"name":"Рецептурный препарат","value":"да","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["27272850:1,0"]}}},{"name":"Органы и системы","value":"нервная система"},{"name":"Назначение","value":"эпилепсия","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["36476390:36618705"]}}},{"name":"Показания к применению","value":"У взрослых в качестве монотерапии или в комбинации с другими противоэпилептическими средствами:\u003Cbr\u003E- лечение генерализованной эпилепсии, особенно при следующих типах припадков (абсансы, клонические, тонические, миоклонические, тонико-клонические, атонические);\u003Cbr\u003E- лечение парциальной эпилепсии (парциальные приступы с вторичной генерализацией или без нее);\u003Cbr\u003E- изменения характера и поведения (обусловленные эпилепсией);\u003Cbr\u003E- специфические синдромы ( Веста, Леннокса-Гасто);\u003Cbr\u003E- маниакально-депрессивный психоз с биполярным течением, не поддающийся лечению препаратами Li+ или другими лекарственными средствами.\u003Cbr\u003EУ детей в качестве монотерапии или в комбинации с другими противоэпилептическими средствами:\u003Cbr\u003E- лечение генерализованной эпилепсии, особенно при следующих типах припадков (абсансы, клонические, тонические, миоклонические, тонико-клонические, атонические);\u003Cbr\u003E- лечение парциальной эпилепсии (парциальные приступы с вторичной генерализацией или без нее);\u003Cbr\u003E- специфические синдромы (Веста, Леннокса-Гасто);\u003Cbr\u003E- фебрильные судороги, детский тик.\u003Cbr\u003E"},{"name":"Противопоказания","value":"Индивидуальная непереносимость препарата, выраженные нарушения функции поджелудочной железы, печеночная недостаточность, острый и хронический гепатит, геморрагический диатез, порфирия, выраженная тромбоцитопения, период лактации, нарушение обмена цикла мочевины (в т.ч. в семейном анамнезе), дети с массой тела менее 20 кг (для данной лекарственной формы), не рекомендуется применять препарат в комбинации с мефлохином; зверобоем продырявленным; ламотриджином.\u003Cbr\u003EС осторожностью:\u003Cbr\u003EУгнетение костномозгового кроветворения (лейкопения, тромбоцитопения, анемия), органические заболевания головного мозга, заболевания печени и поджелудочной железы в анамнезе; гипопротеинемия, умственная отсталость у детей, врожденные ферментопатии, почечная недостаточность, беременность, детский возраст до 3-х лет.\u003Cbr\u003E"},{"name":"Состав","value":"1 таблетка, покрытая пленочной оболочкой, содержит:\u003Cbr\u003Eактивные вещества: вальпроат натрия 133,5 мг, 200,0 мг и 333,0 мг, вальпроевая кислота (эквивалентно вальпроату натрия) 58,0 (66,5) мг, 87,0 (100,0) мг, 145,0 (167,0) мг;\u003Cbr\u003Eвспомогательные вещества: гипромеллоза-К100М (Метоцел-К100М) 50,0 мг / 72,0 мг / 75,0 мг, гипромеллоза-К15М (Метоцел-К15М) 20,0 мг / 27,0 мг /45,0 мг, крахмал (высушенный) 13,0 мг / 21,250 мг / 45,250 мг, тальк очищенный 21,875 мг / 32,40 мг / 43,753 мг, магния стеарат 5,438 мг / 7,950 мг / 13,130 мг, кремния диоксид коллоидный 20,0 мг /30,0мг / 45,0 мг;\u003Cbr\u003Eсостав оболочки: метилметакрилата, диметиламиноэтилметакрилата и бутилметакрилата сополимер (Эудрагит Е-100) 2,350 мг / 3,0 мг / 4,70 мг, титана диоксид 1,875 мг / 2,40 мг / 3,753 мг, макрогол-6000 0,47 мг / 0,60 мг / 0,94 мг, краситель: солнечный закат желтый 0,45 мг / 0,57 мг / 0,90 мг.\u003Cbr\u003E"},{"name":"Действующее вещество","value":"Вальпроевая кислота","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["27144131:28708990"]}}},{"name":"Способ применения и дозы","value":"Режим дозирования препарата Энкорат Хроно подбирается индивидуально в зависимости от возраста и веса пациента, а также с учетом индивидуальной чувствительности к препарату. Препарат принимают внутрь. Суточную дозу следует принимать в 1 или 2 приема, предпочтительно во время еды. Таблетки следует проглатывать целиком, запивая небольшим количеством воды.\u003Cbr\u003EМонотерапия\u003Cbr\u003EВзрослые: начальная доза - 600 мг/день. Увеличивать дозировку на 200 мг каждые три дня до достижения оптимального эффекта. Принимать 1-2 раза в день. Максимально рекомендуемая доза 1-2 г.\u003Cbr\u003EДети с массой тела свыше 20 кг. Начальная доза - 400 мг/день. Повышать постепенно дозировку до достижения оптимальной, обычно 20-30 мг/кг один раз в день или в двух раздельных дозах.\u003Cbr\u003EДети массой тела до 20 кг. Не следует применять Энкорат Хроно детям данной категории.\u003Cbr\u003EПожилые пациенты. Характерно, что объем распределения увеличивается, а объем плазмы снижается. Однако при нормальной функции печени и почек данное увеличение количества свободного препарата клинически не значимо. Режим дозирования Энкорат Хроно у пожилых пациентов сходен с режимом дозирования у взрослых и подбирается индивидуально. У пациентов, у которых необходимый терапевтический эффект достигнут при терапии Энкорат таблетками, возможно применение Энкорат Хроно в соответствующей ежедневной дозировке.\u003Cbr\u003E"},{"name":"Побочные действия","value":"Со стороны ЦНС: тремор, изменения поведения, настроения или психического состояния (депрессия, чувство усталости, галлюцинации, агрессивность, гиперактивное состояние, психозы, необычное возбуждение, двигательное беспокойство или раздражительность), атаксия, головокружение, сонливость, головная боль, энцефалопатия, дизартрия, энурез, ступор, нарушение сознания, кома.\u003Cbr\u003EСо стороны органов чувств: диплопия, нистагм, мелькание \"мушек\" перед глазами.\u003Cbr\u003EСо стороны пищеварительной системы: тошнота, рвота, гастралгия, снижение аппетита или повышение аппетита, диарея, гепатит, запоры, панкреатит, вплоть до тяжелых поражений с летальным исходом (в первые 6 мес лечения, чаще на 2-12 нед).\u003Cbr\u003EСо стороны органов кроветворения и системы гемостаза: угнетение костномозгового кроветворения (анемия, лейкопения), тромбоцитопения, снижение содержания фибриногена и агрегации тромбоцитов, приводящие к развитию гипокоагуляции (сопровождается удлинением времени кровотечения, петехиальными кровоизлияниями, кровоподтеками, гематомами, кровоточивостью и др.).\u003Cbr\u003EСо стороны обмена веществ: снижение или увеличение массы тела.\u003Cbr\u003EАллергические реакции: кожная сыпь, крапивница, ангионевротический отек, фотосенсибилизация, злокачественная экссудативная эритема (синдром Стивенса-Джонсона).\u003Cbr\u003EЛабораторные показатели: гиперкреатининемия, гипераммониемия, гиперглицинемия, гипербилирубинемия, незначительное повышение активности \"печеночных\" трансаминаз, ЛДГ (дозозависимое).\u003Cbr\u003EСо стороны эндокринной системы: дисменорея, вторичная аменорея, увеличение грудных желез, галакторея.\u003Cbr\u003EПрочие: периферические отеки, алопеция.\u003Cbr\u003E"},{"name":"Фармакологическое действие","value":"Противоэпилептическое средство, оказывает центральное миорелаксирующее и седативное действие. Натрия вальпроат увеличивает содержание ГАМК (гамма-аминобутировой кислоты) в центральной нервной системе (ЦНС), что соответственно увеличивает содержание ГАМК в постсинаптических нейронах. Кроме того, натрия вальпроат влияет на перенос ионов калия через мембраны нейронов. В результате подобного воздействия снижается возбудимость и судорожная готовность зон головного мозга.\u003Cbr\u003EУлучшает психическое состояние и настроение больных, обладает антиаритмической активностью.\u003Cbr\u003E"},{"name":"Фармакологическая группа","value":"противоэпилептические средства"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 3 лет"},{"name":"Условия хранения","value":"Хранить в сухом, защищенном от света месте, при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте.\u003Cbr\u003E"},{"name":"Передозировка","value":"Сообщалось о редких случаях передозировки препарата. При этом наблюдалась тошнота, рвота, головокружение, диарея, угнетение дыхания, гипорефлексия, миоз, коматозное состояние.\u003Cbr\u003EЛечение: промывание желудка (не позже 10-12 ч), прием активированного угля, форсированный диурез. При необходимости - стационарное лечение с использованием симптоматической терапии, гемодиализа.\u003Cbr\u003E"},{"name":"Применение при беременности и кормлении грудью","value":"При беременности развитие генерализованных тонико-клонических эпилептических припадков, эпилептического статуса с развитием гипоксии может являться фактором риска летального исхода как для матери, так и для плода.\u003Cbr\u003EВ экспериментальных исследованиях на мышах, крысах и кроликах показано тератогенное действие.\u003Cbr\u003EПо имеющимся данным у человека вальпроат преимущественно вызывает нарушение развития нервной трубки: миеломенингоцеле, расщелина позвоночника (1-2%). Описаны случаи лицевой дисморфии и пороков развития конечностей (особенно укорочение конечностей), а также пороки развития сердечно-сосудистой системы.\u003Cbr\u003EРиск пороков развития выше при комбинированной противоэпилептической терапии, чем при монотерапии вальпроатом натрия. Однако довольно сложно установить причинно-следственную связь между пороками развития плода и другими факторами (в т.ч. генетическими, социальными, факторами внешней среды).\u003Cbr\u003EУчитывая вышеизложенное, при беременности применение препарата возможно только в том случае, когда предполагаемая польза для матери превосходит потенциальный риск для плода.\u003Cbr\u003EЕсли женщина планирует беременность, следует пересмотреть показания для противоэпилептического лечения.\u003Cbr\u003EПри беременности не следует прерывать противоэпилептическое лечение вальпроатом, если оно эффективно. В таких случаях рекомендуется монотерапия; минимальную эффективную суточную дозу следует разделить на несколько приемов.\u003Cbr\u003EВ дополнение к противоэпилептической терапии могут быть добавлены препараты фолиевой кислоты (в дозе 5 мг/сут), т.к. они позволяют минимизировать риск возникновения пороков развития нервной трубки. Однако независимо от того, получает ли пациентка фолаты или нет, в любом случае следует проводить специальный антенатальный контроль состояния нервной трубки или других пороков развития.\u003Cbr\u003EВальпроат может вызывать геморрагический синдром у новорожденных, что, по-видимому, связано с гипофибриногенемией.\u003Cbr\u003EБыли отмечены случаи развития афибриногенемии с летальным исходом. Возможно, это связано с уменьшением ряда факторов свертывания крови. У новорожденных следует контролировать число тромбоцитов, уровень фибриногена в плазме и факторов свертывания крови.\u003Cbr\u003EВальпроат выделяется с грудным молоком в низких концентрациях (от 1% до 10% от концентрации в плазме крови). По данным литературы и на основании небольшого клинического опыта можно планировать грудное вскармливание во время лечения Энкоратом Хроно в виде монотерапии с учетом профиля его безопасности (особенно гематологических расстройств).\u003Cbr\u003E"},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения необходимо соблюдать осторожность при управлении транспортными средствами и занятии др. потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"Во время лечения целесообразен контроль активности \"печеночных\" трансаминаз, концентрации билирубина, картины периферической крови, тромбоцитов крови, состояния системы свертывания крови, активности амилазы (каждые 3 мес, особенно при комбинации с другими противоэпилептическими ЛС).\u003Cbr\u003EПациентам, которые получают другие противоэпилептические ЛС, перевод на прием препарата Энкорат Хроно следует проводить постепенно, достигая клинически эффективной дозы через 2 нед, после чего возможна постепенная отмена других противоэпилептических ЛС. У пациентов, не получавших лечения другими противоэпилептическими ЛС, клинически эффективная доза должна быть достигнута через 1 нед.\u003Cbr\u003EРиск развития побочных эффектов со стороны печени повышен при проведении комбинированной противосудорожной терапии, а также у детей.\u003Cbr\u003EНе допускается прием напитков, содержащих этанол.\u003Cbr\u003EПеред хирургическим вмешательством необходим общий анализ крови (в т.ч. числа тромбоцитов), определение времени кровотечения, показателей коагулограммы.\u003Cbr\u003EПри возникновении на фоне лечения симптоматики \"острого\" живота до начала оперативного вмешательства рекомендуется определить концентрацию амилазы в крови для исключения острого панкреатита.\u003Cbr\u003EВо время лечения следует учитывать возможное искажение результатов анализов мочи при сахарном диабете (вследствие повышения содержания кетопродуктов), показателей функции щитовидной железы.\u003Cbr\u003EПри развитии любых острых серьезных побочных эффектов необходимо немедленно обсудить с врачом целесообразность продолжения или прекращения лечения.\u003Cbr\u003EДля снижения риска развития диспепсических расстройств возможен прием спазмолитиков и обволакивающих ЛС.\u003Cbr\u003EРезкое прекращение приема вальпроевой кислоты может привести к учащению эпилептических припадков.\u003Cbr\u003E"},{"name":"Взаимодействие","value":"Вальпроевая кислота усиливает эффекты, в т.ч. побочные, других противоэпилептических лекарственных средств (ЛС) (фенитоин, ламотриджин), антидепрессантов, антипсихотических ЛС (нейролептиков), анксиолитиков, барбитуратов, ингибиторов моноаминоксидазы, тимолептиков, этанола.\u003Cbr\u003EДобавление вальпроата к клоназепаму в единичных случаях может приводить к усилению выраженности абсансного статуса.\u003Cbr\u003EПри одновременном применении вальпроевой кислоты с барбитуратами или примидоном отмечается повышение концентрации последних в плазме.\u003Cbr\u003EУвеличивает период полувыведения ламотриджина (подавляет ферменты печени, вызывает замедление метаболизма ламотриджина, вследствие чего его период полувыведения удлиняется до 70 ч у взрослых и до 45-55 ч - у детей).\u003Cbr\u003EСнижает клиренс зидовудина на 38%, при этом его период полувыведения не изменяется.\u003Cbr\u003EТрициклические антидепрессанты, ингибиторы моноаминоксидазы, антипсихотические ЛС (нейролептики) и другие ЛС, снижающие порог судорожной активности, уменьшают эффективность препарата Энкората Хроно.\u003Cbr\u003EПри сочетании Энкората Хроно с салицилатами наблюдается усиление эффектов вальпроевой кислоты (вытеснение из связи с белками плазмы), усиливает эффект антиагрегантов (ацетилсалициловая кислота) и непрямых антикоагулянтов.\u003Cbr\u003EПри сочетании с фенобарбиталом, фенитоином, карбамазепином, мефлохином снижается содержание вальпроевой кислоты в сыворотке крови (ускорение метаболизма).\u003Cbr\u003EФелбамат повышает концентрацию вальпроевой кислоты в плазме на 35-50% (необходима коррекция дозы).\u003Cbr\u003EПри одновременном применении препарата Энкорат Хроно с этанолом и другими ЛС, угнетающими ЦНС (трициклические антидепрессанты, ингибиторы моноаминоксидазы и антипсихотические ЛС), возможно усиление угнетения ЦНС.\u003Cbr\u003EЭтанол и другие гепатотоксические ЛС увеличивают вероятность развития поражений печени.\u003Cbr\u003EЭнкорат Хроно не вызывает индукции \"печеночных\" ферментов и не снижает эффективности пероральных контрацептивов.\u003Cbr\u003EМиелотоксические ЛС - повышение риска угнетения костномозгового кроветворения.\u003Cbr\u003EВальпроевая кислота может как повышать, так и снижать концентрацию этосуксимида в сыворотке крови вследствие изменения метаболизма.\u003Cbr\u003EМеропенем снижает плазменную концентрацию вальпроевой кислоты, что может привести к снижению противосудорожного эффекта.\u003Cbr\u003EПри одновременном применении с топираматом повышается риск развития гипераммониемии и энцефалопатии.\u003Cbr\u003E"},{"name":"Источник","value":"\u003Ca href=\"https://www.vidal.ru\" target=\"_blank\"\u003EСправочник лекарственных препаратов Видаль<\u002Fa\u003E"},{"name":"Регистрационный номер","value":"П N014475/01"},{"name":"Дата государственной регистрации","value":"21.10.2020"},{"name":"Владелец регистрационного удостоверения","value":"Sun Pharmaceutical Industries Ltd","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["34324371:35649313","7893318:13888155"]}}},{"name":"Изготовитель","value":"Sun Pharmaceutical Industries Ltd"},{"name":"Фасовщик","value":"Sun Pharmaceutical Industries Ltd"},{"name":"Страна бренда","value":"Индия"},{"name":"Страна-производитель","value":"Индия"},{"name":"Название препарата","value":"Энкорат хроно","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["17796364:18025846"]}}},{"name":"Срок годности","value":"35 мес."}]}},"fullSpecsGrouped":{"16786562083799840517":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"нервная система"},{"name":"Назначение","value":"эпилепсия"},{"name":"Показания к применению","value":"У взрослых в качестве монотерапии или в комбинации с другими противоэпилептическими средствами:\u003Cbr\u003E- лечение генерализованной эпилепсии, особенно при следующих типах припадков (абсансы, клонические, тонические, миоклонические, тонико-клонические, атонические);\u003Cbr\u003E- лечение парциальной эпилепсии (парциальные приступы с вторичной генерализацией или без нее);\u003Cbr\u003E- изменения характера и поведения (обусловленные эпилепсией);\u003Cbr\u003E- специфические синдромы ( Веста, Леннокса-Гасто);\u003Cbr\u003E- маниакально-депрессивный психоз с биполярным течением, не поддающийся лечению препаратами Li+ или другими лекарственными средствами.\u003Cbr\u003EУ детей в качестве монотерапии или в комбинации с другими противоэпилептическими средствами:\u003Cbr\u003E- лечение генерализованной эпилепсии, особенно при следующих типах припадков (абсансы, клонические, тонические, миоклонические, тонико-клонические, атонические);\u003Cbr\u003E- лечение парциальной эпилепсии (парциальные приступы с вторичной генерализацией или без нее);\u003Cbr\u003E- специфические синдромы (Веста, Леннокса-Гасто);\u003Cbr\u003E- фебрильные судороги, детский тик.\u003Cbr\u003E"},{"name":"Противопоказания","value":"Индивидуальная непереносимость препарата, выраженные нарушения функции поджелудочной железы, печеночная недостаточность, острый и хронический гепатит, геморрагический диатез, порфирия, выраженная тромбоцитопения, период лактации, нарушение обмена цикла мочевины (в т.ч. в семейном анамнезе), дети с массой тела менее 20 кг (для данной лекарственной формы), не рекомендуется применять препарат в комбинации с мефлохином; зверобоем продырявленным; ламотриджином.\u003Cbr\u003EС осторожностью:\u003Cbr\u003EУгнетение костномозгового кроветворения (лейкопения, тромбоцитопения, анемия), органические заболевания головного мозга, заболевания печени и поджелудочной железы в анамнезе; гипопротеинемия, умственная отсталость у детей, врожденные ферментопатии, почечная недостаточность, беременность, детский возраст до 3-х лет.\u003Cbr\u003E"},{"name":"Состав","value":"1 таблетка, покрытая пленочной оболочкой, содержит:\u003Cbr\u003Eактивные вещества: вальпроат натрия 133,5 мг, 200,0 мг и 333,0 мг, вальпроевая кислота (эквивалентно вальпроату натрия) 58,0 (66,5) мг, 87,0 (100,0) мг, 145,0 (167,0) мг;\u003Cbr\u003Eвспомогательные вещества: гипромеллоза-К100М (Метоцел-К100М) 50,0 мг / 72,0 мг / 75,0 мг, гипромеллоза-К15М (Метоцел-К15М) 20,0 мг / 27,0 мг /45,0 мг, крахмал (высушенный) 13,0 мг / 21,250 мг / 45,250 мг, тальк очищенный 21,875 мг / 32,40 мг / 43,753 мг, магния стеарат 5,438 мг / 7,950 мг / 13,130 мг, кремния диоксид коллоидный 20,0 мг /30,0мг / 45,0 мг;\u003Cbr\u003Eсостав оболочки: метилметакрилата, диметиламиноэтилметакрилата и бутилметакрилата сополимер (Эудрагит Е-100) 2,350 мг / 3,0 мг / 4,70 мг, титана диоксид 1,875 мг / 2,40 мг / 3,753 мг, макрогол-6000 0,47 мг / 0,60 мг / 0,94 мг, краситель: солнечный закат желтый 0,45 мг / 0,57 мг / 0,90 мг.\u003Cbr\u003E"},{"name":"Действующее вещество","value":"Вальпроевая кислота"},{"name":"Способ применения и дозы","value":"Режим дозирования препарата Энкорат Хроно подбирается индивидуально в зависимости от возраста и веса пациента, а также с учетом индивидуальной чувствительности к препарату. Препарат принимают внутрь. Суточную дозу следует принимать в 1 или 2 приема, предпочтительно во время еды. Таблетки следует проглатывать целиком, запивая небольшим количеством воды.\u003Cbr\u003EМонотерапия\u003Cbr\u003EВзрослые: начальная доза - 600 мг/день. Увеличивать дозировку на 200 мг каждые три дня до достижения оптимального эффекта. Принимать 1-2 раза в день. Максимально рекомендуемая доза 1-2 г.\u003Cbr\u003EДети с массой тела свыше 20 кг. Начальная доза - 400 мг/день. Повышать постепенно дозировку до достижения оптимальной, обычно 20-30 мг/кг один раз в день или в двух раздельных дозах.\u003Cbr\u003EДети массой тела до 20 кг. Не следует применять Энкорат Хроно детям данной категории.\u003Cbr\u003EПожилые пациенты. Характерно, что объем распределения увеличивается, а объем плазмы снижается. Однако при нормальной функции печени и почек данное увеличение количества свободного препарата клинически не значимо. Режим дозирования Энкорат Хроно у пожилых пациентов сходен с режимом дозирования у взрослых и подбирается индивидуально. У пациентов, у которых необходимый терапевтический эффект достигнут при терапии Энкорат таблетками, возможно применение Энкорат Хроно в соответствующей ежедневной дозировке.\u003Cbr\u003E"},{"name":"Побочные действия","value":"Со стороны ЦНС: тремор, изменения поведения, настроения или психического состояния (депрессия, чувство усталости, галлюцинации, агрессивность, гиперактивное состояние, психозы, необычное возбуждение, двигательное беспокойство или раздражительность), атаксия, головокружение, сонливость, головная боль, энцефалопатия, дизартрия, энурез, ступор, нарушение сознания, кома.\u003Cbr\u003EСо стороны органов чувств: диплопия, нистагм, мелькание \"мушек\" перед глазами.\u003Cbr\u003EСо стороны пищеварительной системы: тошнота, рвота, гастралгия, снижение аппетита или повышение аппетита, диарея, гепатит, запоры, панкреатит, вплоть до тяжелых поражений с летальным исходом (в первые 6 мес лечения, чаще на 2-12 нед).\u003Cbr\u003EСо стороны органов кроветворения и системы гемостаза: угнетение костномозгового кроветворения (анемия, лейкопения), тромбоцитопения, снижение содержания фибриногена и агрегации тромбоцитов, приводящие к развитию гипокоагуляции (сопровождается удлинением времени кровотечения, петехиальными кровоизлияниями, кровоподтеками, гематомами, кровоточивостью и др.).\u003Cbr\u003EСо стороны обмена веществ: снижение или увеличение массы тела.\u003Cbr\u003EАллергические реакции: кожная сыпь, крапивница, ангионевротический отек, фотосенсибилизация, злокачественная экссудативная эритема (синдром Стивенса-Джонсона).\u003Cbr\u003EЛабораторные показатели: гиперкреатининемия, гипераммониемия, гиперглицинемия, гипербилирубинемия, незначительное повышение активности \"печеночных\" трансаминаз, ЛДГ (дозозависимое).\u003Cbr\u003EСо стороны эндокринной системы: дисменорея, вторичная аменорея, увеличение грудных желез, галакторея.\u003Cbr\u003EПрочие: периферические отеки, алопеция.\u003Cbr\u003E"},{"name":"Фармакологическое действие","value":"Противоэпилептическое средство, оказывает центральное миорелаксирующее и седативное действие. Натрия вальпроат увеличивает содержание ГАМК (гамма-аминобутировой кислоты) в центральной нервной системе (ЦНС), что соответственно увеличивает содержание ГАМК в постсинаптических нейронах. Кроме того, натрия вальпроат влияет на перенос ионов калия через мембраны нейронов. В результате подобного воздействия снижается возбудимость и судорожная готовность зон головного мозга.\u003Cbr\u003EУлучшает психическое состояние и настроение больных, обладает антиаритмической активностью.\u003Cbr\u003E"},{"name":"Фармакологическая группа","value":"противоэпилептические средства"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 3 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Хранить в сухом, защищенном от света месте, при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте.\u003Cbr\u003E"},{"name":"Передозировка","value":"Сообщалось о редких случаях передозировки препарата. При этом наблюдалась тошнота, рвота, головокружение, диарея, угнетение дыхания, гипорефлексия, миоз, коматозное состояние.\u003Cbr\u003EЛечение: промывание желудка (не позже 10-12 ч), прием активированного угля, форсированный диурез. При необходимости - стационарное лечение с использованием симптоматической терапии, гемодиализа.\u003Cbr\u003E"},{"name":"Применение при беременности и кормлении грудью","value":"При беременности развитие генерализованных тонико-клонических эпилептических припадков, эпилептического статуса с развитием гипоксии может являться фактором риска летального исхода как для матери, так и для плода.\u003Cbr\u003EВ экспериментальных исследованиях на мышах, крысах и кроликах показано тератогенное действие.\u003Cbr\u003EПо имеющимся данным у человека вальпроат преимущественно вызывает нарушение развития нервной трубки: миеломенингоцеле, расщелина позвоночника (1-2%). Описаны случаи лицевой дисморфии и пороков развития конечностей (особенно укорочение конечностей), а также пороки развития сердечно-сосудистой системы.\u003Cbr\u003EРиск пороков развития выше при комбинированной противоэпилептической терапии, чем при монотерапии вальпроатом натрия. Однако довольно сложно установить причинно-следственную связь между пороками развития плода и другими факторами (в т.ч. генетическими, социальными, факторами внешней среды).\u003Cbr\u003EУчитывая вышеизложенное, при беременности применение препарата возможно только в том случае, когда предполагаемая польза для матери превосходит потенциальный риск для плода.\u003Cbr\u003EЕсли женщина планирует беременность, следует пересмотреть показания для противоэпилептического лечения.\u003Cbr\u003EПри беременности не следует прерывать противоэпилептическое лечение вальпроатом, если оно эффективно. В таких случаях рекомендуется монотерапия; минимальную эффективную суточную дозу следует разделить на несколько приемов.\u003Cbr\u003EВ дополнение к противоэпилептической терапии могут быть добавлены препараты фолиевой кислоты (в дозе 5 мг/сут), т.к. они позволяют минимизировать риск возникновения пороков развития нервной трубки. Однако независимо от того, получает ли пациентка фолаты или нет, в любом случае следует проводить специальный антенатальный контроль состояния нервной трубки или других пороков развития.\u003Cbr\u003EВальпроат может вызывать геморрагический синдром у новорожденных, что, по-видимому, связано с гипофибриногенемией.\u003Cbr\u003EБыли отмечены случаи развития афибриногенемии с летальным исходом. Возможно, это связано с уменьшением ряда факторов свертывания крови. У новорожденных следует контролировать число тромбоцитов, уровень фибриногена в плазме и факторов свертывания крови.\u003Cbr\u003EВальпроат выделяется с грудным молоком в низких концентрациях (от 1% до 10% от концентрации в плазме крови). По данным литературы и на основании небольшого клинического опыта можно планировать грудное вскармливание во время лечения Энкоратом Хроно в виде монотерапии с учетом профиля его безопасности (особенно гематологических расстройств).\u003Cbr\u003E"},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения необходимо соблюдать осторожность при управлении транспортными средствами и занятии др. потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"Во время лечения целесообразен контроль активности \"печеночных\" трансаминаз, концентрации билирубина, картины периферической крови, тромбоцитов крови, состояния системы свертывания крови, активности амилазы (каждые 3 мес, особенно при комбинации с другими противоэпилептическими ЛС).\u003Cbr\u003EПациентам, которые получают другие противоэпилептические ЛС, перевод на прием препарата Энкорат Хроно следует проводить постепенно, достигая клинически эффективной дозы через 2 нед, после чего возможна постепенная отмена других противоэпилептических ЛС. У пациентов, не получавших лечения другими противоэпилептическими ЛС, клинически эффективная доза должна быть достигнута через 1 нед.\u003Cbr\u003EРиск развития побочных эффектов со стороны печени повышен при проведении комбинированной противосудорожной терапии, а также у детей.\u003Cbr\u003EНе допускается прием напитков, содержащих этанол.\u003Cbr\u003EПеред хирургическим вмешательством необходим общий анализ крови (в т.ч. числа тромбоцитов), определение времени кровотечения, показателей коагулограммы.\u003Cbr\u003EПри возникновении на фоне лечения симптоматики \"острого\" живота до начала оперативного вмешательства рекомендуется определить концентрацию амилазы в крови для исключения острого панкреатита.\u003Cbr\u003EВо время лечения следует учитывать возможное искажение результатов анализов мочи при сахарном диабете (вследствие повышения содержания кетопродуктов), показателей функции щитовидной железы.\u003Cbr\u003EПри развитии любых острых серьезных побочных эффектов необходимо немедленно обсудить с врачом целесообразность продолжения или прекращения лечения.\u003Cbr\u003EДля снижения риска развития диспепсических расстройств возможен прием спазмолитиков и обволакивающих ЛС.\u003Cbr\u003EРезкое прекращение приема вальпроевой кислоты может привести к учащению эпилептических припадков.\u003Cbr\u003E"},{"name":"Взаимодействие","value":"Вальпроевая кислота усиливает эффекты, в т.ч. побочные, других противоэпилептических лекарственных средств (ЛС) (фенитоин, ламотриджин), антидепрессантов, антипсихотических ЛС (нейролептиков), анксиолитиков, барбитуратов, ингибиторов моноаминоксидазы, тимолептиков, этанола.\u003Cbr\u003EДобавление вальпроата к клоназепаму в единичных случаях может приводить к усилению выраженности абсансного статуса.\u003Cbr\u003EПри одновременном применении вальпроевой кислоты с барбитуратами или примидоном отмечается повышение концентрации последних в плазме.\u003Cbr\u003EУвеличивает период полувыведения ламотриджина (подавляет ферменты печени, вызывает замедление метаболизма ламотриджина, вследствие чего его период полувыведения удлиняется до 70 ч у взрослых и до 45-55 ч - у детей).\u003Cbr\u003EСнижает клиренс зидовудина на 38%, при этом его период полувыведения не изменяется.\u003Cbr\u003EТрициклические антидепрессанты, ингибиторы моноаминоксидазы, антипсихотические ЛС (нейролептики) и другие ЛС, снижающие порог судорожной активности, уменьшают эффективность препарата Энкората Хроно.\u003Cbr\u003EПри сочетании Энкората Хроно с салицилатами наблюдается усиление эффектов вальпроевой кислоты (вытеснение из связи с белками плазмы), усиливает эффект антиагрегантов (ацетилсалициловая кислота) и непрямых антикоагулянтов.\u003Cbr\u003EПри сочетании с фенобарбиталом, фенитоином, карбамазепином, мефлохином снижается содержание вальпроевой кислоты в сыворотке крови (ускорение метаболизма).\u003Cbr\u003EФелбамат повышает концентрацию вальпроевой кислоты в плазме на 35-50% (необходима коррекция дозы).\u003Cbr\u003EПри одновременном применении препарата Энкорат Хроно с этанолом и другими ЛС, угнетающими ЦНС (трициклические антидепрессанты, ингибиторы моноаминоксидазы и антипсихотические ЛС), возможно усиление угнетения ЦНС.\u003Cbr\u003EЭтанол и другие гепатотоксические ЛС увеличивают вероятность развития поражений печени.\u003Cbr\u003EЭнкорат Хроно не вызывает индукции \"печеночных\" ферментов и не снижает эффективности пероральных контрацептивов.\u003Cbr\u003EМиелотоксические ЛС - повышение риска угнетения костномозгового кроветворения.\u003Cbr\u003EВальпроевая кислота может как повышать, так и снижать концентрацию этосуксимида в сыворотке крови вследствие изменения метаболизма.\u003Cbr\u003EМеропенем снижает плазменную концентрацию вальпроевой кислоты, что может привести к снижению противосудорожного эффекта.\u003Cbr\u003EПри одновременном применении с топираматом повышается риск развития гипераммониемии и энцефалопатии.\u003Cbr\u003E"},{"name":"Источник","value":"\u003Ca href=\"https://www.vidal.ru\" target=\"_blank\"\u003EСправочник лекарственных препаратов Видаль<\u002Fa\u003E"},{"name":"Регистрационный номер","value":"П N014475/01"},{"name":"Дата государственной регистрации","value":"21.10.2020"},{"name":"Владелец регистрационного удостоверения","value":"Sun Pharmaceutical Industries Ltd"},{"name":"Изготовитель","value":"Sun Pharmaceutical Industries Ltd"},{"name":"Фасовщик","value":"Sun Pharmaceutical Industries Ltd"},{"name":"Страна бренда","value":"Индия"},{"name":"Страна-производитель","value":"Индия"},{"name":"Название препарата","value":"Энкорат хроно"},{"name":"Срок годности","value":"35 мес."}]}],"transitionId":"tr_8781479074514055406"}}}}
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217 ₽

Скидка: 19%
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Вместо:267 ₽
  • 11-13 июня, самовывоз • 0 ₽
POLZAru
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  • Депакин Хроносфера гран. с пролонг. высвоб., 100 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-0nk7vvdao1e/toggleWishlist":{"skuId":"186868756","productId":1404748446,"offerId":"n-jF3aveiTILGcrK3dOoGg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQvo3myqzQs6Q8EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUInoXrnQUQlMiNWRi42KIFIO3ZwQc=","sign":"JBVVSl4uqZ+5XGYrWbCPzNbWA/M6fHA1+wdgKpPfBsQ="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-0nk7vvdao1e/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Депакин Хроносфера гран. с пролонг. высвоб., 100 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 12 оценок
    Цена 160 ₽
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  • Венлафаксин таб., 75 мг, 30 шт.
    –17 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-srra5evcq1s/toggleWishlist":{"skuId":"228041257","productId":1404748583,"offerId":"mI6lP7Bsvq9xGAEePrFaCg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQvo3myqzQs6Q8EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIp4brnQUQqcTebBjH3NAHIO3ZwQc=","sign":"/paAfpcT1WauiOwwA0TyKVpZU8Gf9RuaUWlBXtPAZ8Q="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-srra5evcq1s/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Венлафаксин таб., 75 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 13 оценок
    Цена 663 ₽ вместо 796
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  • Вальпарин ХР таб. пролонг. действ., 500 мг, 100 шт.
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    Вальпарин ХР таб. пролонг. действ., 500 мг, 100 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 676 ₽
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  • Вальпарин ХР таб. пролонг. действ., 300 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-pjtnk33e2xq/toggleWishlist":{"skuId":"228041249","productId":1404748428,"offerId":"zkLnfrUvpKsaIPQ40zOUIw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQvo3myqzQs6Q8EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIjIXrnQUQocTebBjC3dAHIO3ZwQc=","sign":"I3ZkoZ0meG7BdfO7phDq/wNYcw3RnllJ9meCVXwp3mw="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-pjtnk33e2xq/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Вальпарин ХР таб. пролонг. действ., 300 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 140 ₽
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-pjtnk33e2xq/addToCartButton":{"offerId":"zkLnfrUvpKsaIPQ40zOUIw","skuId":"228041249","pendingCartItem":{"productId":1404748428,"offerId":"zkLnfrUvpKsaIPQ40zOUIw","showPlaceId":"OTNDnItfwRMjN9MRHuEMMqOZiQyFP_Zgd0nCJT-ZvXP-j4rtIldmMn-daT46Ri89s5UDRRlJLWs7E1mNxqzfUUrLwKxEKv9ozBw7TmMSZ675p6DVIeYWzIMV4NR2-o8TXeppwWSwxFLvMgTD7BEJpcrQZZ9IBKn_plEeCupY0I01XpwrPFHwdsPbKPf-_pi5HoCrbrLz3FHasaEgx8bU1g,,","feeShow":"OTNDnItfwRMjN9MRHuEMMqOZiQyFP_Zgd0nCJT-ZvXP-j4rtIldmMn-daT46Ri89s5UDRRlJLWs7E1mNxqzfUUrLwKxEKv9ozBw7TmMSZ675p6DVIeYWzIMV4NR2-o8TXeppwWSwxFLvMgTD7BEJpcrQZZ9IBKn_plEeCupY0I01XpwrPFHwdsPbKPf-_pi5HoCrbrLz3FHasaEgx8bU1g,,","skuId":"228041249","shopId":55106433,"price":{"applicablePriceDiscounts":[],"value":"140","currency":"RUR"},"hid":"15756525","name":"Вальпарин ХР таб. пролонг. действ., 300 мг, 30 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  • Энкорат таб. п/о кш/раств, 300 мг, 100 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-aq0mfelctbq/toggleWishlist":{"skuId":"228128578","productId":1778172916,"offerId":"hr5Wrak5EafrUf9n-DIooA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQvo3myqzQs6Q8EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI9IfzzwYQwu7jbBib1c8GIO3ZwQc=","sign":"0ISlSvc6/l6qvrPQyWW7a681ebSadpeDOtiQkDeGwUM="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-aq0mfelctbq/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Энкорат таб. п/о кш/раств, 300 мг, 100 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 389 ₽
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  • Конвулекс сироп для детей фл., 50 мг/мл, 100 мл
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    Конвулекс сироп для детей фл., 50 мг/мл, 100 мл

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 182 ₽
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  • Депакин энтерик таб. п/о кш/раств., 300 мг, 100 шт.
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    Депакин энтерик таб. п/о кш/раств., 300 мг, 100 шт.

    Рейтинг товара: 5 из 5
    на основе 4 оценки
    Цена 464 ₽
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  • Депакин сироп, 57.64 мг/мл, 150 мл, 1 шт.
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    Депакин сироп, 57.64 мг/мл, 150 мл, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 288 ₽
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  • Атаракс таб. п/о плен., 25 мг, 25 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-mjs46kvnj/toggleWishlist":{"skuId":"228073941","productId":1404748557,"offerId":"dICEtFdqQ71DwTS0QM9M_A","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQvo3myqzQs6Q8EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIjYbrnQUQ1cPgbBig2q4IIO3ZwQc=","sign":"aPfGIw/Q1042D+2LSuEgCufgdNOQcEKB+X3Zle7svM0="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-mjs46kvnj/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Атаракс таб. п/о плен., 25 мг, 25 шт.

    Рейтинг товара: 4.6 из 5
    на основе 154 оценки
    Цена 122 ₽
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  • Тореал таб. п/о, 25 мг, 28 шт.
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    Тореал таб. п/о, 25 мг, 28 шт.

    Рейтинг товара: 4.9 из 5
    на основе 12 оценок
    Цена 209 ₽
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Инструкция

Показания к применению

У взрослых в качестве монотерапии или в комбинации с другими противоэпилептическими средствами:
- лечение генерализованной эпилепсии, особенно при следующих типах припадков (абсансы, клонические, тонические, миоклонические, тонико-клонические, атонические);
- лечение парциальной эпилепсии (парциальные приступы с вторичной генерализацией или без нее);
- изменения характера и поведения (обусловленные эпилепсией);
- специфические синдромы ( Веста, Леннокса-Гасто);
- маниакально-депрессивный психоз с биполярным течением, не поддающийся лечению препаратами Li+ или другими лекарственными средствами.
У детей в качестве монотерапии или в комбинации с другими противоэпилептическими средствами:
- лечение генерализованной эпилепсии, особенно при следующих типах припадков (абсансы, клонические, тонические, миоклонические, тонико-клонические, атонические);
- лечение парциальной эпилепсии (парциальные приступы с вторичной генерализацией или без нее);
- специфические синдромы (Веста, Леннокса-Гасто);
- фебрильные судороги, детский тик.

Противопоказания

Индивидуальная непереносимость препарата, выраженные нарушения функции поджелудочной железы, печеночная недостаточность, острый и хронический гепатит, геморрагический диатез, порфирия, выраженная тромбоцитопения, период лактации, нарушение обмена цикла мочевины (в т.ч. в семейном анамнезе), дети с массой тела менее 20 кг (для данной лекарственной формы), не рекомендуется применять препарат в комбинации с мефлохином; зверобоем продырявленным; ламотриджином.
С осторожностью:
Угнетение костномозгового кроветворения (лейкопения, тромбоцитопения, анемия), органические заболевания головного мозга, заболевания печени и поджелудочной железы в анамнезе; гипопротеинемия, умственная отсталость у детей, врожденные ферментопатии, почечная недостаточность, беременность, детский возраст до 3-х лет.

Способ применения и дозы

Режим дозирования препарата Энкорат Хроно подбирается индивидуально в зависимости от возраста и веса пациента, а также с учетом индивидуальной чувствительности к препарату. Препарат принимают внутрь. Суточную дозу следует принимать в 1 или 2 приема, предпочтительно во время еды. Таблетки следует проглатывать целиком, запивая небольшим количеством воды.
Монотерапия
Взрослые: начальная доза - 600 мг/день. Увеличивать дозировку на 200 мг каждые три дня до достижения оптимального эффекта. Принимать 1-2 раза в день. Максимально рекомендуемая доза 1-2 г.
Дети с массой тела свыше 20 кг. Начальная доза - 400 мг/день. Повышать постепенно дозировку до достижения оптимальной, обычно 20-30 мг/кг один раз в день или в двух раздельных дозах.
Дети массой тела до 20 кг. Не следует применять Энкорат Хроно детям данной категории.
Пожилые пациенты. Характерно, что объем распределения увеличивается, а объем плазмы снижается. Однако при нормальной функции печени и почек данное увеличение количества свободного препарата клинически не значимо. Режим дозирования Энкорат Хроно у пожилых пациентов сходен с режимом дозирования у взрослых и подбирается индивидуально. У пациентов, у которых необходимый терапевтический эффект достигнут при терапии Энкорат таблетками, возможно применение Энкорат Хроно в соответствующей ежедневной дозировке.
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Энкорат Хроно таб. п/о плен. пролонг. высв.
Энкорат Хроно таб. п/о плен. пролонг. высв., 500 мг, 30 шт.
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