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Описание

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Теноф таб. п/о плен., 300 мг, 30 шт.

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4.0
(2)
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Коротко о товаре

Артикул Маркета
4453148071
Тип препарата
Назначение
Действующее вещество
Форма выпуска
таблетки
Инструкция
{"widgets":{"@card/SpecsList":{"/content/page/fancyPage/productSpecsList":{"wrapperProps":{"margins":{"top":4,"bottom":4}},"specsLimit":5,"title":"Коротко о товаре","titleSize":"14","type":"minimal","offset":"s","isHealthCategory":true,"forceShowWidget":true,"withFridge":true}}},"meta":{"/content/page/fancyPage/productSpecsList":{"name":"@card/SpecsList"}},"collections":{"minimalSpecs":{"16658264670205897466":{"specItems":[{"name":"Артикул Маркета","value":"4453148071","withCopyValueButton":true},{"name":"тип препарата","value":"рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"назначение","value":"ВИЧ-инфекция","transition":{"type":"list","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["36476390:36618814"]}}},{"name":"действующее вещество","value":"Тенофовир","transition":{"type":"list","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["27144131:28710739"]}}},{"name":"форма выпуска","value":"таблетки"},{"name":"страна-производитель","value":"Россия"}]}},"compactSpecs":{"16658264670205897466":{"specItems":[{"name":"Артикул Маркета","value":"4453148071","withCopyValueButton":true},{"name":"Тип препарата","value":"Рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"Назначение","value":"ВИЧ-инфекция","transition":{"type":"list","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["36476390:36618814"]}}},{"name":"Действующее вещество","value":"Тенофовир","transition":{"type":"list","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["27144131:28710739"]}}},{"name":"Форма выпуска","value":"Таблетки"}]}},"fullSpecs":{"16658264670205897466":{"specItems":[{"name":"Тип препарата","value":"лекарственный препарат","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["34324371:35649313"]}}},{"name":"Рецептурный препарат","value":"да","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["27272850:1,0"]}}},{"name":"Органы и системы","value":"иммунная система","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["34045610:34515991"]}}},{"name":"Назначение","value":"ВИЧ-инфекция","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["36476390:36618814"]}}},{"name":"Показания к применению","value":"Лечение ВИЧ-1 инфекции в составе комбинированной антиретровирусной терапии у взрослых."},{"name":"Противопоказания","value":"Тенофовир противопоказан пациентам с гиперчувствительностью к любому компоненту препарата.\u003Cbr\u003EС осторожностью\u003Cbr\u003EПочечная недостаточность с клиренсом креатинина менее 50 мл/мин, включая пациентов, находящихся на гемодиализе. При клиренсе креатинина менее 30 мл/мин применение препарата следует избегать; в том случае, если др. лечение недоступно, следует тщательно контролировать функцию почек и скорректировать интервал между введением препарата."},{"name":"Состав","value":"Тенофовира дизопроксил фумарат 300,0 мг\u003Cbr\u003EВспомогательные вещества:\u003Cbr\u003E- Кроскармеллоза натрия 40,0 мг\u003Cbr\u003E- Лактозы моногидрат 153,33 мг\u003Cbr\u003E- Целлюлоза микрокристаллическая 133,34 мг\u003Cbr\u003E- Крахмал прежелатинизированный 33,33 мг\u003Cbr\u003E- Магния стеарат 6,67 мг\u003Cbr\u003E- Опадрай II светло-голубой (Двуокись титана - краситель; FD&C синий № 2, алюминиевый лак сертифицированный в соответствии с законом FD&C (FD&C Blue # 2 Aluminum Lake) - краситель; Гипромеллоза; Лактозы моногидрат (Lactose Monohydrate) - наполнитель; Триацетин (Triacetin)) 32,0 мг."},{"name":"Действующее вещество","value":"Тенофовир","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["27144131:28710739"]}}},{"name":"Способ применения и дозы","value":"Внутрь, не зависимо от приема пищи.\u003Cbr\u003EРекомендованная доза для лечения ВИЧ-1 инфекции: 300 мг 1 раз в день.\u003Cbr\u003EРекомендованный режим дозирования Тенофовира при почечной недостаточности: Клиренс креатинина 30-49 мл/мин: 300 мг каждые 48 ч. Клиренс креатинина 10-29 мл/мин: 300 мг каждые 72-96 ч.\u003Cbr\u003EГемодиализ: 300 мг каждые 7 дней после завершения сеанса диализа.\u003Cbr\u003EРекомендации по режиму дозирования у пациентов с клиренсом креатинина менее 10 мл/мин (без гемодиализа) отсутствуют."},{"name":"Побочные действия","value":"Ниже приведены нежелательные реакции с предполагаемой (возможной) связью с препаратом, которые перечислены по системно-органным классам в порядке убывания их выраженности, со следующей частотой: очень часто (\u003E1/10) и часто (\u003E 1/100, \u003C 1/10), редко (\u003E 1/10000, \u003C 1/1000), очень редко (\u003C1/10000), включая отдельные случаи.\u003Cbr\u003EНарушение метаболизма и питания: очень часто - гипофосфатемия.\u003Cbr\u003EСо стороны нервной системы: очень часто - головокружение.\u003Cbr\u003EСо стороны желудочно-кишечного тракта: очень часто - диарея, рвота, тошнота; часто - метеоризм.\nКомбинированная ретровирусная терапия ассоциировалась с такими метаболическими нарушениями, как гипертриглицеридемия, гиперхолестеринемия, инсулинорезистентность, гипергликемия и гиперлактатемия; перераспределением подкожной клетчатки (липодистрофия).\u003Cbr\u003EЗарегистрированы случаи остеонекроза, особенно у пациентов с факторами риска или при длительной комбинированной противовирусной терапии. Частота неизвестна.\u003Cbr\u003EПостмаркетинговый опыт\u003Cbr\u003EНарушение метаболизма и питания: редко - лактат-ацидоз, частота неизвестна - гипокалиемия\u003Cbr\u003EРеспираторные, торакальные и медиастинальные нарушения: очень редко - диспноэ.\u003Cbr\u003EСо стороны желудочно-кишечного тракта: редко - панкреатит.\u003Cbr\u003EСо стороны гепатобилиарной системы: редко - повышение активности трансаминаз; очень редко - гепатит, частота неизвестна - стеатоз печени.\u003Cbr\u003EСо стороны кожи и подкожных тканей: редко - сыпь.\u003Cbr\u003EСо стороны опорно-двигательного аппарата: частота неизвестна - рабдомиолиз, остеомаляция, мышечная слабость, миопатия.\u003Cbr\u003EСо стороны мочевыделительной системы: редко - острая почечная недостаточность, проксимальная ренальная тубулопатия (включая синдром Фанкони), гиперкреатининемия; очень редко - острый тубулярный некроз; частота неизвестна - нефрит (включая острый интерстициальный), нефрогенный несахарный диабет.\nОбщие нарушения и изменения в месте введения: очень редко - астения."},{"name":"Фармакологическое действие","value":"Тенофовира дизопроксил фумарат in vivo превращается в тенофовир, аналог нуклеозидмонофосфата (нуклеотида) аденозина монофосфата. Тенофовир в последующем превращается в активный метаболит - тенофовира дифосфат. Тенофовир - нуклеотидный ингибитор обратной транскриптазы, обладает специфичной активностью по отношению к вирусу иммунодефицита человека (ВИЧ-1 и ВИЧ-2)."},{"name":"Фармакологическая группа","value":"противовирусное средство","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["34045110:34518654"]}}},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["35947170:36763744"]}}},{"name":"Условия хранения","value":"При температуре не выше 25 °С.\u003Cbr\u003E\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"В случае передозировки, пациент должен быть обследован для выявления возможных признаков интоксикации.\u003Cbr\u003EВ случае необходимости применяется стандартная поддерживающая терапия.\u003Cbr\u003EТенофовир эффективно удаляется гемодиализом с коэффициентом экстракции приблизительно 54%.\u003Cbr\u003EПосле приёма 300 мг тенофовира, 4-часовая процедура гемодиализа приводит к удалению приблизительно 10% принятой дозы тенофовира."},{"name":"Применение при беременности и кормлении грудью","value":"При решении вопроса о применении препарата при беременности необходимо соотнести ожидаемый терапевтический эффект для матери с возможным риском применения препарата для плода.\u003Cbr\u003EВ связи с выявленными изменениями костной ткани на фоне приема препарата, и ограниченным опытом применения рекомендуется с осторожностью применять препарат во время беременности.\u003Cbr\u003EЖенщины детородного возраста во время лечения должны использовать надежные методы контрацепции. Кормящие матери: ВИЧ-инфицированные женщины должны быть проинструктированы об исключении грудного вскармливания."},{"name":"Особые указания","value":"Сообщалось о случаях развития лактат-ацидоза и выраженной гепатомегалии со стеатозом, включая летальные исходы, при использовании нуклеозидных аналогов;\u003Cbr\u003EВпервые возникшая или прогрессирующая почечная недостаточность может привести к острой почечной недостаточности и синдрому Фанкони. Необходимо определение клиренса креатинина перед началом лечения тенофовиром. Необходим контроль клиренса креатинина и фосфора в сыворотке крови у пациентов с повышенным риском развития или прогрессирования почечной недостаточности. Необходимо избегать применения тенофовира одновременно или после недавнего лечения нефротоксичными препаратами.\u003Cbr\u003EНеобходимо исключать применение тенофовира одновременно с комбинированными противовирусными препаратами, в состав которых включен тенофовир (например, Трувада, Атрипла) и адефовира депивоксил. Тенофовир должен использоваться только как часть соответствующей антиретровирусной комбинированной терапии у ВИЧ-1 инфицированных пациентов.\u003Cbr\u003EСнижение плотности костной ткани наблюдались у ВИЧ-инфицированных пациентов. Необходимо проводить контроль плотности костной ткани у пациентов с патологическим переломом в анамнезе, равно как и у пациентов, с повышенным риском остеопении. Перераспределение/накопление жировых отложений наблюдалось у ВИЧ-инфицированных пациентов, получающих комбинированную антиретровирусную терапию. \u003Cbr\u003EСиндром восстановления иммунитета наблюдался у ВИЧ-инфицированных пациентов. Может потребоваться дальнейшая оценка и лечение.\u003Cbr\u003EНефротоксичность\u003Cbr\u003EПри применении Тенофовира может развиться синдром Фанкони, сопровождающийся гипофосфатемией, гипоурикемией, протеинурией, нормогликемической глюкозурией; в некоторых случаях может развиться острая почечная недостаточность. \u003Cbr\u003EНа ранних стадиях течение может быть бессимптомным, либо сопровождаться миалгиями; в большинстве случаев симптомы исчезают при прекращении приема препарата. К факторам риска относятся низкую массу тела, и наличие заболевания почек на момент начала терапии. Частота развития нефротоксичных побочных эффектов крайне низкая у пациентов с исходно нормальной функцией почек.\u003Cbr\u003EРезистенстность\u003Cbr\u003EЧувствительность снижена у пациентов с тремя и более мутациями резистентности к аналогам тимидина, включающими 41L и 210W. Чувствительность сохраняется при других сочетаниях тимидиновых мутаций и повышается при наличии мутации M184V."},{"name":"Взаимодействие","value":"Диданозин: увеличение концентрации диданозина при совместном применении; необходимо их применять с осторожностью и осуществлять контроль проявлений токсичности диданозина (например, панкреатит, нейропатия). Комбинация тенофовира с диданозином не рекомендуется; если это оправданно, необходимо рассмотреть возможность снижения дозы или прекращение терапии диданозином.\u003Cbr\u003EТенофовир комбинируют со сниженными дозами диданозина (например, пациентам с массой тела \u003E 60 кг назначают диданозин 250 мг 1 раз в сутки; \u003C 60 кг - 200 мг 1 раз в сутки). С другой стороны, такая низкодозовая комбинация, возможно, характеризуется низкой противовирусной активностью и недостаточным приростом количества С04-лимфоцитов, на что указывает высокая частота неэффективности терапии при применении этой комбинации с добавлением эфавиренза или невирапина.\u003Cbr\u003EАтазанавир: снижение концентрации атазанавира при совместном применении и увеличение концентраций тенофовира. Необходимо применять тенофовир с атазанавиром только с дополнительным усилением действия последнего ритонавиром.\u003Cbr\u003EЛопинавир/ритонавир: увеличение концентраций тенофовира при совместном применении.\u003Cbr\u003EДарунавир: увеличивает концентрацию тенофовира на 20-25 %. Препараты следует применять в стандартных дозах, при этом необходимо тщательно мониторировать нефротоксическое действие тенофовира.\u003Cbr\u003EТенофовир в основном выводится из организма через почки, совместное применение тенофовира с препаратами, которые уменьшают почечную функцию или сокращают/прекращают активную тубулярную секрецию, может увеличить сывороточную концентрацию тенофовира и/или увеличить концентрации других препаратов, выводимых через почки.\u003Cbr\u003EГанцикловир, валганцикловир и цидофовир конкурируют с тенофовиром за активную канальцевую секрецию почками, в результате чего повышается уровень тенофовира или одновременно применяемого лекарственного препарата; требуется настороженность в отношении возможных побочных эффектов. Нефротоксичные препараты могут также повышать концентрацию тенофовира в сыворотке крови."},{"name":"Регистрационный номер","value":"ЛСР-002600/10"},{"name":"Дата государственной регистрации","value":"04.10.2019"},{"name":"Владелец регистрационного удостоверения","value":"Hetero Labs Limited","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["34324371:35649313","7893318:17784423"]}}},{"name":"Изготовитель","value":"Макиз-Фарма"},{"name":"Страна бренда","value":"Индия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Теноф","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["17796364:18202850"]}}},{"name":"Срок годности","value":"589 дн."}]}},"fullSpecsGrouped":{"16658264670205897466":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"иммунная система"},{"name":"Назначение","value":"ВИЧ-инфекция"},{"name":"Показания к применению","value":"Лечение ВИЧ-1 инфекции в составе комбинированной антиретровирусной терапии у взрослых."},{"name":"Противопоказания","value":"Тенофовир противопоказан пациентам с гиперчувствительностью к любому компоненту препарата.\u003Cbr\u003EС осторожностью\u003Cbr\u003EПочечная недостаточность с клиренсом креатинина менее 50 мл/мин, включая пациентов, находящихся на гемодиализе. При клиренсе креатинина менее 30 мл/мин применение препарата следует избегать; в том случае, если др. лечение недоступно, следует тщательно контролировать функцию почек и скорректировать интервал между введением препарата."},{"name":"Состав","value":"Тенофовира дизопроксил фумарат 300,0 мг\u003Cbr\u003EВспомогательные вещества:\u003Cbr\u003E- Кроскармеллоза натрия 40,0 мг\u003Cbr\u003E- Лактозы моногидрат 153,33 мг\u003Cbr\u003E- Целлюлоза микрокристаллическая 133,34 мг\u003Cbr\u003E- Крахмал прежелатинизированный 33,33 мг\u003Cbr\u003E- Магния стеарат 6,67 мг\u003Cbr\u003E- Опадрай II светло-голубой (Двуокись титана - краситель; FD&C синий № 2, алюминиевый лак сертифицированный в соответствии с законом FD&C (FD&C Blue # 2 Aluminum Lake) - краситель; Гипромеллоза; Лактозы моногидрат (Lactose Monohydrate) - наполнитель; Триацетин (Triacetin)) 32,0 мг."},{"name":"Действующее вещество","value":"Тенофовир"},{"name":"Способ применения и дозы","value":"Внутрь, не зависимо от приема пищи.\u003Cbr\u003EРекомендованная доза для лечения ВИЧ-1 инфекции: 300 мг 1 раз в день.\u003Cbr\u003EРекомендованный режим дозирования Тенофовира при почечной недостаточности: Клиренс креатинина 30-49 мл/мин: 300 мг каждые 48 ч. Клиренс креатинина 10-29 мл/мин: 300 мг каждые 72-96 ч.\u003Cbr\u003EГемодиализ: 300 мг каждые 7 дней после завершения сеанса диализа.\u003Cbr\u003EРекомендации по режиму дозирования у пациентов с клиренсом креатинина менее 10 мл/мин (без гемодиализа) отсутствуют."},{"name":"Побочные действия","value":"Ниже приведены нежелательные реакции с предполагаемой (возможной) связью с препаратом, которые перечислены по системно-органным классам в порядке убывания их выраженности, со следующей частотой: очень часто (\u003E1/10) и часто (\u003E 1/100, \u003C 1/10), редко (\u003E 1/10000, \u003C 1/1000), очень редко (\u003C1/10000), включая отдельные случаи.\u003Cbr\u003EНарушение метаболизма и питания: очень часто - гипофосфатемия.\u003Cbr\u003EСо стороны нервной системы: очень часто - головокружение.\u003Cbr\u003EСо стороны желудочно-кишечного тракта: очень часто - диарея, рвота, тошнота; часто - метеоризм.\nКомбинированная ретровирусная терапия ассоциировалась с такими метаболическими нарушениями, как гипертриглицеридемия, гиперхолестеринемия, инсулинорезистентность, гипергликемия и гиперлактатемия; перераспределением подкожной клетчатки (липодистрофия).\u003Cbr\u003EЗарегистрированы случаи остеонекроза, особенно у пациентов с факторами риска или при длительной комбинированной противовирусной терапии. Частота неизвестна.\u003Cbr\u003EПостмаркетинговый опыт\u003Cbr\u003EНарушение метаболизма и питания: редко - лактат-ацидоз, частота неизвестна - гипокалиемия\u003Cbr\u003EРеспираторные, торакальные и медиастинальные нарушения: очень редко - диспноэ.\u003Cbr\u003EСо стороны желудочно-кишечного тракта: редко - панкреатит.\u003Cbr\u003EСо стороны гепатобилиарной системы: редко - повышение активности трансаминаз; очень редко - гепатит, частота неизвестна - стеатоз печени.\u003Cbr\u003EСо стороны кожи и подкожных тканей: редко - сыпь.\u003Cbr\u003EСо стороны опорно-двигательного аппарата: частота неизвестна - рабдомиолиз, остеомаляция, мышечная слабость, миопатия.\u003Cbr\u003EСо стороны мочевыделительной системы: редко - острая почечная недостаточность, проксимальная ренальная тубулопатия (включая синдром Фанкони), гиперкреатининемия; очень редко - острый тубулярный некроз; частота неизвестна - нефрит (включая острый интерстициальный), нефрогенный несахарный диабет.\nОбщие нарушения и изменения в месте введения: очень редко - астения."},{"name":"Фармакологическое действие","value":"Тенофовира дизопроксил фумарат in vivo превращается в тенофовир, аналог нуклеозидмонофосфата (нуклеотида) аденозина монофосфата. Тенофовир в последующем превращается в активный метаболит - тенофовира дифосфат. Тенофовир - нуклеотидный ингибитор обратной транскриптазы, обладает специфичной активностью по отношению к вирусу иммунодефицита человека (ВИЧ-1 и ВИЧ-2)."},{"name":"Фармакологическая группа","value":"противовирусное средство"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"При температуре не выше 25 °С.\u003Cbr\u003E\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"В случае передозировки, пациент должен быть обследован для выявления возможных признаков интоксикации.\u003Cbr\u003EВ случае необходимости применяется стандартная поддерживающая терапия.\u003Cbr\u003EТенофовир эффективно удаляется гемодиализом с коэффициентом экстракции приблизительно 54%.\u003Cbr\u003EПосле приёма 300 мг тенофовира, 4-часовая процедура гемодиализа приводит к удалению приблизительно 10% принятой дозы тенофовира."},{"name":"Применение при беременности и кормлении грудью","value":"При решении вопроса о применении препарата при беременности необходимо соотнести ожидаемый терапевтический эффект для матери с возможным риском применения препарата для плода.\u003Cbr\u003EВ связи с выявленными изменениями костной ткани на фоне приема препарата, и ограниченным опытом применения рекомендуется с осторожностью применять препарат во время беременности.\u003Cbr\u003EЖенщины детородного возраста во время лечения должны использовать надежные методы контрацепции. Кормящие матери: ВИЧ-инфицированные женщины должны быть проинструктированы об исключении грудного вскармливания."},{"name":"Особые указания","value":"Сообщалось о случаях развития лактат-ацидоза и выраженной гепатомегалии со стеатозом, включая летальные исходы, при использовании нуклеозидных аналогов;\u003Cbr\u003EВпервые возникшая или прогрессирующая почечная недостаточность может привести к острой почечной недостаточности и синдрому Фанкони. Необходимо определение клиренса креатинина перед началом лечения тенофовиром. Необходим контроль клиренса креатинина и фосфора в сыворотке крови у пациентов с повышенным риском развития или прогрессирования почечной недостаточности. Необходимо избегать применения тенофовира одновременно или после недавнего лечения нефротоксичными препаратами.\u003Cbr\u003EНеобходимо исключать применение тенофовира одновременно с комбинированными противовирусными препаратами, в состав которых включен тенофовир (например, Трувада, Атрипла) и адефовира депивоксил. Тенофовир должен использоваться только как часть соответствующей антиретровирусной комбинированной терапии у ВИЧ-1 инфицированных пациентов.\u003Cbr\u003EСнижение плотности костной ткани наблюдались у ВИЧ-инфицированных пациентов. Необходимо проводить контроль плотности костной ткани у пациентов с патологическим переломом в анамнезе, равно как и у пациентов, с повышенным риском остеопении. Перераспределение/накопление жировых отложений наблюдалось у ВИЧ-инфицированных пациентов, получающих комбинированную антиретровирусную терапию. \u003Cbr\u003EСиндром восстановления иммунитета наблюдался у ВИЧ-инфицированных пациентов. Может потребоваться дальнейшая оценка и лечение.\u003Cbr\u003EНефротоксичность\u003Cbr\u003EПри применении Тенофовира может развиться синдром Фанкони, сопровождающийся гипофосфатемией, гипоурикемией, протеинурией, нормогликемической глюкозурией; в некоторых случаях может развиться острая почечная недостаточность. \u003Cbr\u003EНа ранних стадиях течение может быть бессимптомным, либо сопровождаться миалгиями; в большинстве случаев симптомы исчезают при прекращении приема препарата. К факторам риска относятся низкую массу тела, и наличие заболевания почек на момент начала терапии. Частота развития нефротоксичных побочных эффектов крайне низкая у пациентов с исходно нормальной функцией почек.\u003Cbr\u003EРезистенстность\u003Cbr\u003EЧувствительность снижена у пациентов с тремя и более мутациями резистентности к аналогам тимидина, включающими 41L и 210W. Чувствительность сохраняется при других сочетаниях тимидиновых мутаций и повышается при наличии мутации M184V."},{"name":"Взаимодействие","value":"Диданозин: увеличение концентрации диданозина при совместном применении; необходимо их применять с осторожностью и осуществлять контроль проявлений токсичности диданозина (например, панкреатит, нейропатия). Комбинация тенофовира с диданозином не рекомендуется; если это оправданно, необходимо рассмотреть возможность снижения дозы или прекращение терапии диданозином.\u003Cbr\u003EТенофовир комбинируют со сниженными дозами диданозина (например, пациентам с массой тела \u003E 60 кг назначают диданозин 250 мг 1 раз в сутки; \u003C 60 кг - 200 мг 1 раз в сутки). С другой стороны, такая низкодозовая комбинация, возможно, характеризуется низкой противовирусной активностью и недостаточным приростом количества С04-лимфоцитов, на что указывает высокая частота неэффективности терапии при применении этой комбинации с добавлением эфавиренза или невирапина.\u003Cbr\u003EАтазанавир: снижение концентрации атазанавира при совместном применении и увеличение концентраций тенофовира. Необходимо применять тенофовир с атазанавиром только с дополнительным усилением действия последнего ритонавиром.\u003Cbr\u003EЛопинавир/ритонавир: увеличение концентраций тенофовира при совместном применении.\u003Cbr\u003EДарунавир: увеличивает концентрацию тенофовира на 20-25 %. Препараты следует применять в стандартных дозах, при этом необходимо тщательно мониторировать нефротоксическое действие тенофовира.\u003Cbr\u003EТенофовир в основном выводится из организма через почки, совместное применение тенофовира с препаратами, которые уменьшают почечную функцию или сокращают/прекращают активную тубулярную секрецию, может увеличить сывороточную концентрацию тенофовира и/или увеличить концентрации других препаратов, выводимых через почки.\u003Cbr\u003EГанцикловир, валганцикловир и цидофовир конкурируют с тенофовиром за активную канальцевую секрецию почками, в результате чего повышается уровень тенофовира или одновременно применяемого лекарственного препарата; требуется настороженность в отношении возможных побочных эффектов. Нефротоксичные препараты могут также повышать концентрацию тенофовира в сыворотке крови."},{"name":"Регистрационный номер","value":"ЛСР-002600/10"},{"name":"Дата государственной регистрации","value":"04.10.2019"},{"name":"Владелец регистрационного удостоверения","value":"Hetero Labs Limited"},{"name":"Изготовитель","value":"Макиз-Фарма"},{"name":"Страна бренда","value":"Индия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Теноф"},{"name":"Срок годности","value":"589 дн."}]}],"transitionId":"tr_5784039962369167840"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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    Цена 1 620 ₽
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  • Эфавиренз таб. п/о плен., 600 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-8o0376el173/toggleWishlist":{"skuId":"101805864822","productId":1767096518,"offerId":"UCKg27kC9sAZuv6hsFwT7Q","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhYPsz5rDgsElEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIxoHPygYQ9u7ooPsCGISpsggg8tzBBw==","sign":"xiVigrdiOF3x53RMSPM9YD7xX9ydXiavfTkPupbvhVU="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-8o0376el173/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Эфавиренз таб. п/о плен., 600 мг, 30 шт.

    Цена 734 ₽
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  • Кивекса таб. п/о плен., 600 мг+300 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-j0e9gsb40g/toggleWishlist":{"skuId":"101334419749","productId":265133458,"offerId":"wv8lc87aYOZJe1gxhfhl-w","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhYPsz5rDgsElEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIkru2fhClkoLA+QIYuMLZByDy3MEH","sign":"2nLRk+2+L/bEXb6ZTO9pumRNFrByaiUVvdvDKLWUjFQ="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-j0e9gsb40g/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Кивекса таб. п/о плен., 600 мг+300 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 3 467 ₽
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  • Трувада таб. п/о плен., 245 мг+200 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-7mmxr69qemo/toggleWishlist":{"skuId":"101333037785","productId":663079056,"offerId":"Mf5kF_0G3481N9s7ycyJBQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhYPsz5rDgsElEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIkJGXvAIQ2eWtv/kCGPq8vQgg8tzBBw==","sign":"uXUBHlJi5/O9MJQQek+QjLug0lVu0fzHCA/2fyYMIWw="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-7mmxr69qemo/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Трувада таб. п/о плен., 245 мг+200 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 13 105 ₽
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  • Тивикай таб. п/о плен., 50 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-23xcj7lcvm6/toggleWishlist":{"skuId":"101335820771","productId":663075034,"offerId":"-O5TMqdvK_larB3NaLP1MQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhYPsz5rDgsElEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI2vGWvAIQ49PXwPkCGLjC2Qcg8tzBBw==","sign":"W7J3m2M2prht0hT0JX7eSf9XIupDyq3VGZfK5++zHWQ="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-23xcj7lcvm6/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Тивикай таб. п/о плен., 50 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 6 757 ₽
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  • Тивикай таб. п/о плен., 50 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-j0bjn2ob3g/toggleWishlist":{"skuId":"101335161731","productId":677218000,"offerId":"vbC_Wy6_YiXHDqM9DHqOJg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhYPsz5rDgsElEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI0I32wgIQg7evwPkCGLjC2Qcg8tzBBw==","sign":"Kwj4jQXE5APmAm+mTBT7erxXPLIP6eQPsEGiX0PkHrY="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-j0bjn2ob3g/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Тивикай таб. п/о плен., 50 мг, 30 шт.

    Рейтинг товара: 4.2 из 5
    на основе 5 оценок
    Цена 7 034 ₽
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  • Лорета таб. п/о плен., 2.5 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-w48v7c2s2jq/toggleWishlist":{"skuId":"101335818766","productId":453475048,"offerId":"ZqxfhTClXi-7eg_JorISFQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhYPsz5rDgsElEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI6PWd2AEQjsTXwPkCGOq+hhEg8tzBBw==","sign":"KYSGn5uBbkUfLMb/yYuU5XGrTyHoAnlT1g7uSh1dykc="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-w48v7c2s2jq/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Лорета таб. п/о плен., 2.5 мг, 30 шт.

    Рейтинг товара: 4.3 из 5
    на основе 3 оценки
    Цена 1 340 ₽
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  • Летрозол таб. п/о плен., 2.5 мг, 30 шт.
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    Летрозол таб. п/о плен., 2.5 мг, 30 шт.

    Рейтинг товара: 4 из 5
    на основе 2 оценки
    Цена 7 714 ₽
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  • Кипферон супп. ваг. и рект., 200 мг+500000 МЕ, 10 шт.
    –17 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-1aaei83hp9r/toggleWishlist":{"skuId":"101333037775","productId":646923103,"offerId":"x33YmPLbPMUxDPoaW0wHhw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhYPsz5rDgsElEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI34a9tAIQz+Wtv/kCGJfk0Acg8tzBBw==","sign":"+cs+LibjIfvTSUaFseDSB5txXGRDIuze+pvg4Ka6lN0="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-1aaei83hp9r/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Кипферон супп. ваг. и рект., 200 мг+500000 МЕ, 10 шт.

    Рейтинг товара: 4.8 из 5
    на основе 82 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 185 ₽ вместо 1 197
    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  • Вобэнзим таб. п/о кш/раств., 40 шт.
    –1 %
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    Вобэнзим таб. п/о кш/раств., 40 шт.

    Рейтинг товара: 4.8 из 5
    на основе 249 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 922 ₽ вместо 931
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  • Зидолам таб. п/о плен., 300 мг+150 мг, 60 шт.
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    Зидолам таб. п/о плен., 300 мг+150 мг, 60 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 940 ₽
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Инструкция

Показания к применению

Лечение ВИЧ-1 инфекции в составе комбинированной антиретровирусной терапии у взрослых.

Противопоказания

Тенофовир противопоказан пациентам с гиперчувствительностью к любому компоненту препарата.
С осторожностью
Почечная недостаточность с клиренсом креатинина менее 50 мл/мин, включая пациентов, находящихся на гемодиализе. При клиренсе креатинина менее 30 мл/мин применение препарата следует избегать; в том случае, если др. лечение недоступно, следует тщательно контролировать функцию почек и скорректировать интервал между введением препарата.

Способ применения и дозы

Внутрь, не зависимо от приема пищи.
Рекомендованная доза для лечения ВИЧ-1 инфекции: 300 мг 1 раз в день.
Рекомендованный режим дозирования Тенофовира при почечной недостаточности: Клиренс креатинина 30-49 мл/мин: 300 мг каждые 48 ч. Клиренс креатинина 10-29 мл/мин: 300 мг каждые 72-96 ч.
Гемодиализ: 300 мг каждые 7 дней после завершения сеанса диализа.
Рекомендации по режиму дозирования у пациентов с клиренсом креатинина менее 10 мл/мин (без гемодиализа) отсутствуют.
Полная инструкция
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Теноф таб. п/о плен.
Теноф таб. п/о плен., 300 мг, 30 шт.
4.0
(2)
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3 вопроса
Инструкция

404 ₽

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4.0
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У продавца:2 оценки·1 отзыв
У всех продавцов:25 оценок·4 отзыва
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user avatar
7 месяцев назад • Дмитрий Лебедев • Куплен на Маркете
Достоинства: помогает
Недостатки: возможен рецидив
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