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Коротко о товаре

Артикул Маркета
3123956988
Тип препарата
Назначение
Действующее вещество
Возраст
от 3 лет
Инструкция
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Для взрослых суточная доза составляет, как правило, 8–32 мг. Эффективность ондансетрона может быть увеличена путем разового в/в введения глюкокортикоида (например 20 мг дексаметазона) до начала химиотерапии.\u003Cbr\u003EДля предупреждения отсроченной рвоты, возникающей через 24 ч после начала химио- или радиотерапии, рекомендуется продолжить прием препарата внутрь по 8 мг каждые 12 ч или ректально по 16 мг 1 раз в сутки в течение 5 дней.\u003Cbr\u003EДетям старше 2 лет — 5 мг/м2 в/в непосредственно перед началом курса с последующим приемом внутрь в дозе 4 мг через 12 ч; после окончания курса рекомендуется продолжать лечение по 4 мг 2 раза в день внутрь в течение 5 дней.\u003Cbr\u003EПредупреждение послеоперационной тошноты и рвоты: взрослым — в разовой дозе 4 мг в/м или в/в (медленно) в начале наркоза или внутрь в дозе 16 мг за 1 ч до начала наркоза; детям старше 2 лет — только парентерально в разовой дозе 0,1 мг/кг (максимально до 4 мг) в виде медленной в/в инъекции до или после анестезии.\u003Cbr\u003EКупирование развившейся послеоперационной тошноты и рвоты: взрослым — 4 мг в/м или в/в; детям старше 2 лет — 0,1 мг/кг (до 4 мг) в/в медленно.\u003Cbr\u003EВ/м в один и тот же участок тела ондансетрон может быть введен в дозе, не превышающей 4 мг!\u003Cbr\u003EПри выраженном нарушении функций печени в значительной степени уменьшается клиренс ондансетрона, увеличивается T1/2 из плазмы, поэтому не следует превышать суточную дозу (8 мг)."},{"name":"Побочные действия","value":"Со стороны органов ЖКТ: запор/диарея, сухость во рту, икота, транзиторное повышение уровня АСТ и АЛТ.\u003Cbr\u003EСо стороны нервной системы и органов чувств: головная боль, головокружение, спонтанные двигательные расстройства и судороги, нарушение остроты зрения, экстрапирамидные нарушения (при парентеральном применении).\u003Cbr\u003EСо стороны сердечно-сосудистой системы и крови (кроветворение, гемостаз): обморок, боль в грудной клетке, в ряде случаев с депрессией сегмента ST, брадикардия, аритмия, артериальная гипотензия.\u003Cbr\u003EАллергические реакции: крапивница, бронхоспазм, ларингоспазм, ангионевротический отек, анафилаксия.\u003Cbr\u003EПрочие: лихорадка, ощущение жара, прилив крови к лицу, гипокалиемия, гиперкреатинемия, местные реакции (боль, покраснение и жжение в месте инъекции); жжение в области ануса и прямой кишки (суппозитории)."},{"name":"Фармакологическое действие","value":"Противорвотное.\u003Cbr\u003EПо конкурентному типу высокоселективно блокирует центральные (хеморецепторы триггерной зоны, рвотный центр) и периферические серотониновые 5-HT3-рецепторы. Подавляет рвотный рефлекс, устраняет и предупреждает рвоту, опосредованную высвобождением серотонина при применении цитостатических противобластомных средств, лучевой терапии, в послеоперационном периоде. При многократном введении замедляет перистальтику и прохождение содержимого по кишечнику."},{"name":"Фармакологическая группа","value":"противорвотное средство - серотониновых рецепторов антагонист"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 3 лет"},{"name":"Условия хранения","value":"В защищенном от света месте, при температуре не выше 25 °C. Срок годности 2 года"},{"name":"Передозировка","value":"Симптомы: усиление выраженности побочных реакций.\u003Cbr\u003EЛечение: симптоматическая терапия. Специфический антидот неизвестен."},{"name":"Применение при беременности и кормлении грудью","value":"Беременность\u003Cbr\u003EБезопасность применения ондансетрона во время беременности у человека не установлена. Доклинические исследования не выявили прямого и косвенного негативного влияния на развитие эмбриона, плода, гестацию, пери- и постнатальное развитие. Однако применение ондансетрона у беременных женщин противопоказано в связи с тем, что результаты доклинических исследований не всегда можно экстраполировать на безопасность применения у человека.\u003Cbr\u003EГрудное вскармливание\u003Cbr\u003EИсследования показали, что ондансетрон проникает в грудное молоко лактирующих животных. При применении ондансетрона у кормящих матерей грудное вскармливание следует прекратить (см. раздел \"Противопоказания\").\u003Cbr\u003E"},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В случае возникновения побочных реакций со стороны нервной системы пациентам рекомендуется воздержаться от управления автомобилем и другими механизмами, а также занятий видами деятельности, требующими концентрации внимания, быстроты психомоторных функций."},{"name":"Особые указания","value":"Необходимо особое наблюдение за больными с признаками подострой непроходимости кишечника (из-за увеличения времени прохождения через толстую кишку).\u003Cbr\u003EОсобые указания\u003Cbr\u003EНе рекомендуется вводить в одном шприце с другими препаратами. Инъекционные формы разводят только рекомендуемыми растворами. Совместим с инфузионными растворами натрия и калия хлорида, декстрозы, маннита, Рингера. Перед их введением следует убедиться в отсутствии крупных частиц и изменений цвета (если позволяет контейнер); преципитат, содержащийся на стенках ампулы (на активность и безопасность не влияет), растворяют путем энергичного встряхивания; ампулы не автоклавируют, защищают от воздействия света."},{"name":"Взаимодействие","value":"Поскольку ондансетрон метаболизируется ферментной системой печени (цитохром P450), требуется осторожность при совместном применении с индукторами изоферментов CYP2D6 и CYP3A цитохрома P450 (барбитураты, карбамазепин, гризеофульвин, закись азота, папаверин, фенилбутазон, фенитоин и, вероятно, другие гидантоины, рифампицин, толбутамид), а также с ингибиторами изоферментов P450 CYP2D6 и CYP3A (аллопуринол, антибиотики-макролиды, антидепрессанты-ингибиторы МАО, хлорамфеникол, циметидин, эстрогенсодержащие пероральные контрацептивы, дилтиазем, дисульфирам, эритромицин, вальпроевая кислота, вальпроат натрия, флуконазол, фторхинолоны, изониазид, кетоконазол, ловастатин, метронидазол, омепразол, пропранолол, хинидин, хинин, верапамил)."},{"name":"Регистрационный номер","value":"ЛCP-001138/10"},{"name":"Дата государственной регистрации","value":"20.11.2018"},{"name":"Владелец регистрационного удостоверения","value":"TEVA","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["34324371:35649313","7893318:14909142"]}}},{"name":"Страна бренда","value":"Израиль"},{"name":"Страна-производитель","value":"Венгрия"},{"name":"Название препарата","value":"Ондансетрон","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["17796364:17844711"]}}},{"name":"Срок годности","value":"36 мес."}]}},"fullSpecsGrouped":{"17872562675883331924":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"желудок, пищеварительная система"},{"name":"Назначение","value":"рвота, тошнота"},{"name":"Показания к применению","value":"Тошнота и рвота (профилактика и лечение) при цитотоксической химиотерапии, лучевой терапии, в послеоперационном периоде."},{"name":"Противопоказания","value":"- Повышенная чувствительность к действующему веществу или любому другому компоненту, входящему в состав препарата;\u003Cbr\u003E\n- одновременное применение ондансетрона с апоморфином;\u003Cbr\u003E\n- врожденный синдром удлинения интервала QT;\u003Cbr\u003E\n- беременность и период грудного вскармливания;\u003Cbr\u003E\n- детский возраст до 3 лет при профилактике и лечении тошноты и рвоты, вызванных цитостатической химиотерапией;\u003Cbr\u003E\n- детский возраст до 18 лет при профилактике и лечении тошноты и рвоты, вызванных лучевой терапией, а также при профилактике послеоперационной тошноты и рвоты."},{"name":"Состав","value":"1 таблетка, покрытая пленочной оболочкой, содержит:\u003Cbr\u003Eактивное вещество: ондансетрон (ондансетрона гидрохлорида дигидрат) 8,0 мг (10,0 мг);\u003Cbr\u003Eвспомогательные вещества: лактозы моногидрат, карбоксиметилкрахмал натрия, тип А, целлюлоза микрокристаллическая, крахмал кукурузный прежелатинизированный, магния стеарат;\u003Cbr\u003Eоболочка: опадрай желтый 02G22211 (гипромеллоза Е464, титана диоксид Е171, макрогол-6000, макрогол-400, краситель железа оксид желтый Е172).\u003Cbr\u003E"},{"name":"Действующее вещество","value":"Ондансетрон"},{"name":"Способ применения и дозы","value":"Цитостатическая терапия: выбор режима дозирования определяется эметогенностью противоопухолевой терапии. Для взрослых суточная доза составляет, как правило, 8–32 мг. Эффективность ондансетрона может быть увеличена путем разового в/в введения глюкокортикоида (например 20 мг дексаметазона) до начала химиотерапии.\u003Cbr\u003EДля предупреждения отсроченной рвоты, возникающей через 24 ч после начала химио- или радиотерапии, рекомендуется продолжить прием препарата внутрь по 8 мг каждые 12 ч или ректально по 16 мг 1 раз в сутки в течение 5 дней.\u003Cbr\u003EДетям старше 2 лет — 5 мг/м2 в/в непосредственно перед началом курса с последующим приемом внутрь в дозе 4 мг через 12 ч; после окончания курса рекомендуется продолжать лечение по 4 мг 2 раза в день внутрь в течение 5 дней.\u003Cbr\u003EПредупреждение послеоперационной тошноты и рвоты: взрослым — в разовой дозе 4 мг в/м или в/в (медленно) в начале наркоза или внутрь в дозе 16 мг за 1 ч до начала наркоза; детям старше 2 лет — только парентерально в разовой дозе 0,1 мг/кг (максимально до 4 мг) в виде медленной в/в инъекции до или после анестезии.\u003Cbr\u003EКупирование развившейся послеоперационной тошноты и рвоты: взрослым — 4 мг в/м или в/в; детям старше 2 лет — 0,1 мг/кг (до 4 мг) в/в медленно.\u003Cbr\u003EВ/м в один и тот же участок тела ондансетрон может быть введен в дозе, не превышающей 4 мг!\u003Cbr\u003EПри выраженном нарушении функций печени в значительной степени уменьшается клиренс ондансетрона, увеличивается T1/2 из плазмы, поэтому не следует превышать суточную дозу (8 мг)."},{"name":"Побочные действия","value":"Со стороны органов ЖКТ: запор/диарея, сухость во рту, икота, транзиторное повышение уровня АСТ и АЛТ.\u003Cbr\u003EСо стороны нервной системы и органов чувств: головная боль, головокружение, спонтанные двигательные расстройства и судороги, нарушение остроты зрения, экстрапирамидные нарушения (при парентеральном применении).\u003Cbr\u003EСо стороны сердечно-сосудистой системы и крови (кроветворение, гемостаз): обморок, боль в грудной клетке, в ряде случаев с депрессией сегмента ST, брадикардия, аритмия, артериальная гипотензия.\u003Cbr\u003EАллергические реакции: крапивница, бронхоспазм, ларингоспазм, ангионевротический отек, анафилаксия.\u003Cbr\u003EПрочие: лихорадка, ощущение жара, прилив крови к лицу, гипокалиемия, гиперкреатинемия, местные реакции (боль, покраснение и жжение в месте инъекции); жжение в области ануса и прямой кишки (суппозитории)."},{"name":"Фармакологическое действие","value":"Противорвотное.\u003Cbr\u003EПо конкурентному типу высокоселективно блокирует центральные (хеморецепторы триггерной зоны, рвотный центр) и периферические серотониновые 5-HT3-рецепторы. Подавляет рвотный рефлекс, устраняет и предупреждает рвоту, опосредованную высвобождением серотонина при применении цитостатических противобластомных средств, лучевой терапии, в послеоперационном периоде. При многократном введении замедляет перистальтику и прохождение содержимого по кишечнику."},{"name":"Фармакологическая группа","value":"противорвотное средство - серотониновых рецепторов антагонист"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 3 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"В защищенном от света месте, при температуре не выше 25 °C. Срок годности 2 года"},{"name":"Передозировка","value":"Симптомы: усиление выраженности побочных реакций.\u003Cbr\u003EЛечение: симптоматическая терапия. Специфический антидот неизвестен."},{"name":"Применение при беременности и кормлении грудью","value":"Беременность\u003Cbr\u003EБезопасность применения ондансетрона во время беременности у человека не установлена. Доклинические исследования не выявили прямого и косвенного негативного влияния на развитие эмбриона, плода, гестацию, пери- и постнатальное развитие. Однако применение ондансетрона у беременных женщин противопоказано в связи с тем, что результаты доклинических исследований не всегда можно экстраполировать на безопасность применения у человека.\u003Cbr\u003EГрудное вскармливание\u003Cbr\u003EИсследования показали, что ондансетрон проникает в грудное молоко лактирующих животных. При применении ондансетрона у кормящих матерей грудное вскармливание следует прекратить (см. раздел \"Противопоказания\").\u003Cbr\u003E"},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В случае возникновения побочных реакций со стороны нервной системы пациентам рекомендуется воздержаться от управления автомобилем и другими механизмами, а также занятий видами деятельности, требующими концентрации внимания, быстроты психомоторных функций."},{"name":"Особые указания","value":"Необходимо особое наблюдение за больными с признаками подострой непроходимости кишечника (из-за увеличения времени прохождения через толстую кишку).\u003Cbr\u003EОсобые указания\u003Cbr\u003EНе рекомендуется вводить в одном шприце с другими препаратами. Инъекционные формы разводят только рекомендуемыми растворами. Совместим с инфузионными растворами натрия и калия хлорида, декстрозы, маннита, Рингера. Перед их введением следует убедиться в отсутствии крупных частиц и изменений цвета (если позволяет контейнер); преципитат, содержащийся на стенках ампулы (на активность и безопасность не влияет), растворяют путем энергичного встряхивания; ампулы не автоклавируют, защищают от воздействия света."},{"name":"Взаимодействие","value":"Поскольку ондансетрон метаболизируется ферментной системой печени (цитохром P450), требуется осторожность при совместном применении с индукторами изоферментов CYP2D6 и CYP3A цитохрома P450 (барбитураты, карбамазепин, гризеофульвин, закись азота, папаверин, фенилбутазон, фенитоин и, вероятно, другие гидантоины, рифампицин, толбутамид), а также с ингибиторами изоферментов P450 CYP2D6 и CYP3A (аллопуринол, антибиотики-макролиды, антидепрессанты-ингибиторы МАО, хлорамфеникол, циметидин, эстрогенсодержащие пероральные контрацептивы, дилтиазем, дисульфирам, эритромицин, вальпроевая кислота, вальпроат натрия, флуконазол, фторхинолоны, изониазид, кетоконазол, ловастатин, метронидазол, омепразол, пропранолол, хинидин, хинин, верапамил)."},{"name":"Регистрационный номер","value":"ЛCP-001138/10"},{"name":"Дата государственной регистрации","value":"20.11.2018"},{"name":"Владелец регистрационного удостоверения","value":"TEVA"},{"name":"Страна бренда","value":"Израиль"},{"name":"Страна-производитель","value":"Венгрия"},{"name":"Название препарата","value":"Ондансетрон"},{"name":"Срок годности","value":"36 мес."}]}],"transitionId":"tr_15314490203265258725"}}}}
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Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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    Цена 169 ₽
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  • Латран таб. п/о плен., 4 мг, 10 шт.
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    Латран таб. п/о плен., 4 мг, 10 шт.

    Рейтинг товара: 4.4 из 5
    на основе 27 оценок
    Цена 406 ₽
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  • Латран р-р для в/в и в/м введ. амп., 2 мг/мл, 2 мл, 5 шт.
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    Латран р-р для в/в и в/м введ. амп., 2 мг/мл, 2 мл, 5 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 156 ₽
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  • Ондансетрон р-р д/в-в и в/м введ. амп., 2 мг/мл, 4 мл, 5 шт.
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    Ондансетрон р-р д/в-в и в/м введ. амп., 2 мг/мл, 4 мл, 5 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 181 ₽
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  • Ондансетрон р-р д для в/в и в/м введ., 2 мг/мл, 4 мл, 5 шт.
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    Ондансетрон р-р д для в/в и в/м введ., 2 мг/мл, 4 мл, 5 шт.

    Цена 320 ₽
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  • Ондансетрон р-р для в/в и в/м введ. амп., 2 мг/мл, 4 мл, 5 шт.
    –18 %
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    Ондансетрон р-р для в/в и в/м введ. амп., 2 мг/мл, 4 мл, 5 шт.

    Цена 231 ₽ вместо 281
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  • Ондансетрон-Альтфарм супп. рект., 16 мг, 2 шт.
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    Ондансетрон-Альтфарм супп. рект., 16 мг, 2 шт.

    Рейтинг товара: 4 из 5
    на основе 2 оценки
    Цена 694 ₽
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  • Панум таб. п/о кш/раств., 40 мг, 28 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-kw0o0mvobkg/toggleWishlist":{"skuId":"101459305743","productId":186870031,"offerId":"tXuaMA9qqu_TxTCSjWTUOQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQmJ7r/Z/a1dkZEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIj9KNWRCPysj7+QIYgN3QByDa2cEH","sign":"UBc6dnrcb4scLPU7hoZuABHp7+Uibz2dISc6gqEG8BA="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-kw0o0mvobkg/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Панум таб. п/о кш/раств., 40 мг, 28 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 462 ₽
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  • Нольпаза таб.п/о кш/раств. плен., 20 мг, 14 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-heivhkjaarq/toggleWishlist":{"skuId":"186853223","productId":1400799425,"offerId":"r4b62iYDMVe0ZgPPVKUCPQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQmJ7r/Z/a1dkZEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIwYH6mwUQ586MWRi21YcEINrZwQc=","sign":"WGWKc3220SSIVsg5Ex187OLa55Z3fAfqMyUP+5RTKdQ="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-heivhkjaarq/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Нольпаза таб.п/о кш/раств. плен., 20 мг, 14 шт.

    Рейтинг товара: 4.6 из 5
    на основе 98 оценок
    Цена 262 ₽
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  • Домперидон-Тева таб. п/о плен., 10 мг, 30 шт.
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    Домперидон-Тева таб. п/о плен., 10 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 386 ₽
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  • Пассажикс таб. жев., 10 мг, 10 шт.
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    Пассажикс таб. жев., 10 мг, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 335 ₽
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Инструкция

Показания к применению

Тошнота и рвота (профилактика и лечение) при цитотоксической химиотерапии, лучевой терапии, в послеоперационном периоде.

Противопоказания

- Повышенная чувствительность к действующему веществу или любому другому компоненту, входящему в состав препарата;
- одновременное применение ондансетрона с апоморфином;
- врожденный синдром удлинения интервала QT;
- беременность и период грудного вскармливания;
- детский возраст до 3 лет при профилактике и лечении тошноты и рвоты, вызванных цитостатической химиотерапией;
- детский возраст до 18 лет при профилактике и лечении тошноты и рвоты, вызванных лучевой терапией, а также при профилактике послеоперационной тошноты и рвоты.

Способ применения и дозы

Цитостатическая терапия: выбор режима дозирования определяется эметогенностью противоопухолевой терапии. Для взрослых суточная доза составляет, как правило, 8–32 мг. Эффективность ондансетрона может быть увеличена путем разового в/в введения глюкокортикоида (например 20 мг дексаметазона) до начала химиотерапии.
Для предупреждения отсроченной рвоты, возникающей через 24 ч после начала химио- или радиотерапии, рекомендуется продолжить прием препарата внутрь по 8 мг каждые 12 ч или ректально по 16 мг 1 раз в сутки в течение 5 дней.
Детям старше 2 лет — 5 мг/м2 в/в непосредственно перед началом курса с последующим приемом внутрь в дозе 4 мг через 12 ч; после окончания курса рекомендуется продолжать лечение по 4 мг 2 раза в день внутрь в течение 5 дней.
Предупреждение послеоперационной тошноты и рвоты: взрослым — в разовой дозе 4 мг в/м или в/в (медленно) в начале наркоза или внутрь в дозе 16 мг за 1 ч до начала наркоза; детям старше 2 лет — только парентерально в разовой дозе 0,1 мг/кг (максимально до 4 мг) в виде медленной в/в инъекции до или после анестезии.
Купирование развившейся послеоперационной тошноты и рвоты: взрослым — 4 мг в/м или в/в; детям старше 2 лет — 0,1 мг/кг (до 4 мг) в/в медленно.
В/м в один и тот же участок тела ондансетрон может быть введен в дозе, не превышающей 4 мг!
При выраженном нарушении функций печени в значительной степени уменьшается клиренс ондансетрона, увеличивается T1/2 из плазмы, поэтому не следует превышать суточную дозу (8 мг).
Полная инструкция
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Ондансетрон-Тева таб. п/о плен.
Ондансетрон-Тева таб. п/о плен., 8 мг, 10 шт.
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