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Описание

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Риманал ВМ капли гл. фл., 1.5 мг/мл, 5 мл

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Коротко о товаре

Артикул Маркета
4540851285
Тип препарата
Назначение
Действующее вещество
Возраст
от 2 лет
Инструкция
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Офтальмогипертензия (в монотерапии или в комбинации с другими препаратами, снижающими внутриглазное давление (ВГД))."},{"name":"Противопоказания","value":"Одновременная терапия ингибиторами монооксидазы;\u003Cbr\u003Eгиперчувствительность к бримонидину и другим компонентам препарата;\u003Cbr\u003Eпериод грудного вскармливания;\u003Cbr\u003Eдетский возраст до 2 лет."},{"name":"Состав","value":"На 1 мл препарата:\u003Cbr\u003Eдействующее вещество: бримонидина тартрат 1,50 мг;\u003Cbr\u003Eвспомогательные вещества: бензалкония хлорид 0,05 мг, борная кислота 2,29 мг, кальция хлорида дигидрат 0,20 мг, магния хлорида гексагидрат 0,06 мг, калия хлорид 1,40 мг, натрия бората декагидрат 0,95 мг, гипромеллоза 7,50 мг, натрия хлорид 5,80 мг, натрия гидроксид 10 % раствор до pH 6,5-7,5, хлористоводородная кислота 1 М раствор до pH 6,5-7,5, вода для инъекций до 1 мл."},{"name":"Действующее вещество","value":"Бримонидин","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["27144131:28709629"]}}},{"name":"Способ применения и дозы","value":"Местно.\u003Cbr\u003EВ конъюнктивальный мешок пораженного глаза по 1 капле 3 раза в сутки с интервалом между введениями около 8 ч.\u003Cbr\u003EДля снижения системной экспозиции препарата сразу после закапывания рекомендуется надавить на область слезного мешка у внутреннего угла глаза (закрывая слезную точку) в течение 1 минуты.\u003Cbr\u003EРиманал ВМ можно применять с другими офтальмологическими препаратами с целью снижения ВГД. При использовании двух и более препаратов необходимо делать 5 минутный перерыв между инстилляциями.\u003Cbr\u003EПрименение Риманал ВМ не изучали у пациентов с нарушением функции печени или почек; при лечении таких пациентов необходимо соблюдать осторожность.\u003Cbr\u003EПрименение у детей\u003Cbr\u003EВ 3-месячном исследовании фазы 3 у детей в возрасте 2-7 лет с глаукомой и с недостаточным контролем заболевания при применении 0-блокаторов отмечали высокую частоту возникновения сонливости (55 %) при применении 0,2 % бримонидина в качестве дополнительной терапии. Сонливость была сильно выражена у 8 % детей и являлась причиной прекращения лечения в 13 % случаев. Частота сонливости снижалась с увеличением возраста и была минимальной у 7-летних детей (25 %), но в большей степени определялась массой тела: сонливость чаще отмечалась у детей с массой ≤20 кг (63 %) по сравнению с детьми с массой \u003E20 кг (25 %).\u003Cbr\u003EБезопасность и эффективность Риманал ВМ у детей младше 2 лет не установлены.\u003Cbr\u003EПрименение у пожилых людей\u003Cbr\u003EУ пожилых людей не отмечали отличий в безопасности или эффективности по сравнению с другими взрослыми пациентами. Сmах и период полувыведения бримонидина были сходными у пожилых (65 лет и старше) и более молодых пациентов взрослой популяции, что демонстрирует отсутствие значимого влияния возраста на системное всасывание и на выведение бримонидина."},{"name":"Побочные действия","value":"Наиболее часто встречаемыми нежелательными реакциями со стороны органа зрения являются аллергический конъюнктивит, гиперемия конъюнктивы, зуд слизистой оболочки глаз и кожи век. Большинство нежелательных реакций имели быстропроходящий характер и легкую степень тяжести (не требующую прекращения лечения).\u003Cbr\u003EПо данным клинических исследований симптомы аллергических реакций со стороны глаз наблюдались в 12,7 % случаев (являясь причиной прекращения лечения в 11,5 % случаев), при этом у большинства пациентов они проявлялись через 3-6 месяцев применения препарата (согласно актуальной информации об опыте применения препарата Риманал ВМ в концентрации 0,2 %).\u003Cbr\u003EЧастота побочных эффектов, выявленных в ходе исследований, оценивалась следующим образом: очень часто (\u003E10 %), часто (\u003E1 % и \u003C10 %); нечасто (\u003E0,1 % и \u003C1 %), редко (\u003E0,01 % и \u003C0,1 %).\u003Cbr\u003EВ клинических исследованиях препарата Риманал ВМ выявлены следующие побочные эффекты:\u003Cbr\u003EСо стороны органа зрения:\u003Cbr\u003Eочень часто - аллергический конъюнктивит, гиперемия конъюнктивы, зуд слизистой оболочки глаз и кожи век, затуманивание зрения;\u003Cbr\u003Eчасто - ощущение жжения, фолликулез конъюнктивы или фолликулярный конъюнктивит, местные аллергические реакции со стороны глаз (в т.ч. кератоконъюнктивит), нарушение зрения, блефарит, блефароконъюнктивит, катаракта, отек конъюнктивы, кровоизлияние в конъюнктиву, конъюнктивит, ретенционное слезотечение, эпифора, слизистое отделяемое из глаз, сухость и раздражение слизистой оболочки глаз, боль в глазу, отек век, покраснение век, ощущение инородного тела в глазах, кератит, поражения век, фотосенсибилизация, колющее ощущение в глазу, поверхностная точечная кератопатия, слезотечение, выпадение полей зрения, отслойка стекловидного тела, кровоизлияния в стекловидное тело, плавающие помутнения в стекловидном теле и снижение остроты зрения;\u003Cbr\u003Eнечасто - эрозия роговицы, ячмень;\u003Cbr\u003EСо стороны центральной нервной системы:\u003Cbr\u003Eчасто - головная боль, сонливость, бессонница, головокружение;\u003Cbr\u003EСо стороны сердечно-сосудистой системы:\u003Cbr\u003Eчасто - повышение или снижение артериального давления;\u003Cbr\u003EСо стороны органов дыхания:\u003Cbr\u003Eчасто - бронхит, фарингит, кашель, одышка;\u003Cbr\u003Eнечасто - сухость слизистой оболочки носа; апноэ;\u003Cbr\u003EСо стороны желудочно-кишечного тракта:\u003Cbr\u003Eчасто - желудочно-кишечные расстройства - диспепсия, сухость слизистой оболочки полости рта;\u003Cbr\u003EСо стороны кожи и подкожно-жировой клетчатки: часто - сыпь;\u003Cbr\u003EИнфекционные и паразитарные заболевания:\u003Cbr\u003Eчасто - гриппоподобный синдром, инфекционное заболевание (озноб и респираторная инфекция), ринит, синусит, в т.ч. инфекционный;\u003Cbr\u003EЛабораторные показатели:\u003Cbr\u003Eчасто - гиперхолестеринемия;\u003Cbr\u003EДругие: часто - общие аллергические реакции, астения, утомляемость, нарушение вкуса; нечасто - извращение вкуса.\u003Cbr\u003EУ детей (в том числе у новорожденных и грудных детей) отмечено: апноэ, брадикардия, снижение артериального давления (АД), гипотермия, мышечная гипотония, бледность, сонливость, снижение внимания.\u003Cbr\u003EОтдельные серьёзные побочные реакции, такие как возникновение комы, летаргии и угнетения дыхания у новорожденного и грудного ребенка, т.е. в возрасте, в котором использование препарата не одобрено, отмечались при применении препарата в концентрации 0,2 %, превышающей концентрацию данного препарата.\u003Cbr\u003EВ постмаркетинговый период дополнительно получены сообщения о следующих побочных эффектах:\u003Cbr\u003EСо стороны органа зрения: частота неизвестна - ирит, сухой кератоконъюнктивит, миоз;\u003Cbr\u003EСо стороны центральной нервной системы: депрессия, синкопе;\u003Cbr\u003EСо стороны сердечно-сосудистой системы: брадикардия, тахикардия;\u003Cbr\u003EСо стороны желудочно-кишечного тракта: тошнота;\u003Cbr\u003EСо стороны кожи и подкожно-жировой клетчатки: местные кожные реакции (эритема, зуд век, отек лица, сыпь и вазодилатация сосудов кожи век и лица), гиперчувствительность.\u003Cbr\u003EСообщения о подозреваемых нежелательных реакциях\u003Cbr\u003EСообщения о подозреваемых нежелательных реакциях после регистрации лекарственного средства являются важными. При выявлении у пациента серьезной нежелательной реакции на лекарственное средство или появлении новой нежелательной реакции, не описанной в данном разделе, просим проинформировать в соответствии с Национальной системой фармаконадзора."},{"name":"Фармакологическое действие","value":"Риманал ВМ - селективный α2-адреномиметик. Максимальное снижение внутриглазного давления (ВГД) достигается через 2 часа. Гипотензивное действие бримонидина обеспечивается за счет снижения образования и повышения оттока внутриглазной жидкости по увеосклеральному пути."},{"name":"Фармакологическая группа","value":"противоглаукомное средство - альфа 2-адреномиметик селективный"},{"name":"Форма выпуска","value":"капли"},{"name":"Способ применения/введения","value":"местный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["35947170:36763743"]}}},{"name":"Минимальный возраст применения","value":"от 2 лет"},{"name":"Условия хранения","value":"Хранить при температуре не выше 25 °C.\u003Cbr\u003EХранить в недоступном для детей месте!\u003Cbr\u003EПосле вскрытия флакона препарат использовать в течение 28 дней."},{"name":"Передозировка","value":"Передозировка при местном применении\u003Cbr\u003EСимптомы передозировки при местном применении представлены ранее отмеченными нежелательными реакциями.\u003Cbr\u003EПередозировка при случайном проглатывании\u003Cbr\u003EСообщений о случаях передозировки препарата у взрослых достаточно мало.\u003Cbr\u003EНа сегодняшний день зарегистрирована одна нежелательная реакция, связанная со снижением артериального давления (АД). При развитии артериальной гипотензии впоследствии отмечалась рикошетная гипертензия.\u003Cbr\u003EПри случайном приеме препарата внутрь возможны следующие симптомы: угнетение центральной нервной системы, сонливость, угнетение и потеря сознания, снижение АД, брадикардия, снижение температуры тела, цианоз кожных покровов, апноэ, астения, рвота, судороги, аритмия, миоз.\u003Cbr\u003EПри выявлении симптомов передозировки необходимо проведение симптоматической терапии, контроль проходимости дыхательных путей.\u003Cbr\u003EПередозировка у детей\u003Cbr\u003EСимптомы передозировки бримонидином наблюдались при лечении врожденной глаукомы или случайном приеме внутрь у детей младшего возраста. В случае развития передозировки требуются поддерживающая и симптоматическая терапия, а также может быть необходима интенсивная терапия с применением интубации. Полное купирование симптомов передозировки бримонидином во всех сообщенных случаях происходило в течение 6-24 часов."},{"name":"Применение при беременности и кормлении грудью","value":"В доклинических исследованиях не выявлено тератогенного влияния на плод. Однако установлено, что бримонидин проникает через плацентарный барьер и в незначительном количестве содержится в плазме крови плода. Контролируемых исследований у беременных женщин не проводилось. В период беременности бримонидин следует применять только в случаях, когда ожидаемая польза для матери превышает возможный риск для плода.\u003Cbr\u003EВ исследованиях на животных установлено, что бримонидин проникает в грудное молоко. На время применения препарата кормление грудью следует прекратить."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Применение препарата Риманал ВМ может сопровождаться эпизодами слабости и сонливости у некоторых пациентов. В том случае, если работа пациента связана с потенциально опасными видами деятельности, вождением автотранспортных средств, его необходимо заранее предупредить о возможном снижении концентрации внимания и скорости психомоторных реакций, и рекомендовать воздержаться от этих видов деятельности."},{"name":"Особые указания","value":"Необходимы тщательное наблюдение и мониторинг состояния пациентов в возрасте от 2 до 7 лет (особенно с массой тела до 20 кг) в связи с высокой частотой встречаемости и выраженности сонливости.\u003Cbr\u003EПри развитии аллергических реакций на препарат Риманал ВМ необходимо прекратить лечение и обратиться к врачу.\u003Cbr\u003EВозможно повышение внутриглазного давления в случае развития реакций замедленной гиперчувствительности.\u003Cbr\u003EСообщалось о случаях бактериального кератита при использовании многодозовых флаконов офтальмологических средств для местного применения, инфицированных пациентами, которые, в большинстве случаев, имели сопутствующее заболевание роговицы или сопутствующее поражение эпителия роговицы и конъюнктивы.\u003Cbr\u003EПри неправильном обращении или если наконечник флакона-капельницы соприкасается с глазом или, окружающими глаз структурами, офтальмологические препараты могут инфицироваться бактериями, вызывающими глазные инфекции. Использование инфицированного раствора может привести к серьезному повреждению глаза с последующей потерей зрения. Не использовать раствор после истечения срока годности, указанного на флаконе.\u003Cbr\u003EЕсли была перенесена офтальмологическая операция или возникло сопутствующее глазное заболевание (например, травма или инфекция), то следует немедленно проконсультироваться с врачом касательно продолжения использования данного многодозового флакона-капельницы.\u003Cbr\u003EСрок годности препарата после первого вскрытия флакон-капельницы составляет 28 дней. Риманал ВМ содержит бензалкония хлорид, часто используемый в качестве консерванта в офтальмологических лекарственных препаратах. Бензалкония хлорид может вызывать раздражение глаз, точечную кератопатию и/или токсическую язвенную кератопатию, а также абсорбироваться мягкими контактными линзами и обесцвечивать их.\u003Cbr\u003EС осторожностью:\u003Cbr\u003EУ пациентов с почечной недостаточностью (клиренс креатинина ниже 40 мл/мин), печеночной недостаточностью.\u003Cbr\u003EУ пациентов с ортостатической гипотензией, сердечной недостаточностью и недостаточностью мозгового кровообращения, депрессией, синдромом Рейно, облитерирующим тромбангиитом. Бримонидин может усиливать тяжесть течения заболеваний, обусловленных сосудистой недостаточностью. Хотя 0,2 % бримонидин в клинических исследованиях оказывал минимальное влияние и на частоту сердечных сокращений, при лечении пациентов с тяжелыми сердечно-сосудистыми заболеваниями, а также пациентов с нестабильным и неконтролируемым течением сосудистых заболеваний необходимо соблюдать осторожность.\u003Cbr\u003EУ детей в возрасте от 2 до 7 лет."},{"name":"Взаимодействие","value":"Исследований по изучению лекарственного взаимодействия препарата Риманал ВМ не проводилось, однако при его одновременном применении следует учитывать возможность усиления эффекта лекарственных средств, угнетающих центральную нервную систему (алкоголь, барбитураты, производные опия, седативные препараты, общие анестетики). Учитывая способность препаратов группы альфа-адреномиметиков снижать АД и частоту сердечных сокращений (ЧСС), с осторожностью следует одновременно применять гипотензивные лекарственные препараты и сердечные гликозиды.\u003Cbr\u003EВ связи с известным уменьшением выраженности гипотензивного эффекта клонидина (α2- адреномиметик) при совместном применении с трициклическими антидепрессантами, нельзя исключить возможного снижения эффективности препарата Риманал ВМ при сопутствующем лечении трициклическими антидепрессантами.\u003Cbr\u003EС осторожностью следует применять препарат Риманал ВМ с трициклическими антидепрессантами, которые могут оказывать влияние на метаболизм аминов и их распределение в сосудистом русле."},{"name":"Регистрационный номер","value":"ЛП-006370"},{"name":"Дата государственной регистрации","value":"27.07.2020"},{"name":"Владелец регистрационного удостоверения","value":"World Medicine Ilac San Ve Tic","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-glaz-i-ushei","categoryId":"15756892","navnodeId":"72496","glfilters":["34324371:35649313","7893318:20327270"]}}},{"name":"Изготовитель","value":"World Medicine Ilac San ve Tic"},{"name":"Страна бренда","value":"Турция"},{"name":"Страна-производитель","value":"Турция"},{"name":"Срок годности","value":"1 г."}]}},"fullSpecsGrouped":{"14551168174773456821":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"глаза"},{"name":"Назначение","value":"открытоугольная глаукома, офтальмогипертензия, повышение внутриглазного давления"},{"name":"Показания к применению","value":"Открытоугольная глаукома. Офтальмогипертензия (в монотерапии или в комбинации с другими препаратами, снижающими внутриглазное давление (ВГД))."},{"name":"Противопоказания","value":"Одновременная терапия ингибиторами монооксидазы;\u003Cbr\u003Eгиперчувствительность к бримонидину и другим компонентам препарата;\u003Cbr\u003Eпериод грудного вскармливания;\u003Cbr\u003Eдетский возраст до 2 лет."},{"name":"Состав","value":"На 1 мл препарата:\u003Cbr\u003Eдействующее вещество: бримонидина тартрат 1,50 мг;\u003Cbr\u003Eвспомогательные вещества: бензалкония хлорид 0,05 мг, борная кислота 2,29 мг, кальция хлорида дигидрат 0,20 мг, магния хлорида гексагидрат 0,06 мг, калия хлорид 1,40 мг, натрия бората декагидрат 0,95 мг, гипромеллоза 7,50 мг, натрия хлорид 5,80 мг, натрия гидроксид 10 % раствор до pH 6,5-7,5, хлористоводородная кислота 1 М раствор до pH 6,5-7,5, вода для инъекций до 1 мл."},{"name":"Действующее вещество","value":"Бримонидин"},{"name":"Способ применения и дозы","value":"Местно.\u003Cbr\u003EВ конъюнктивальный мешок пораженного глаза по 1 капле 3 раза в сутки с интервалом между введениями около 8 ч.\u003Cbr\u003EДля снижения системной экспозиции препарата сразу после закапывания рекомендуется надавить на область слезного мешка у внутреннего угла глаза (закрывая слезную точку) в течение 1 минуты.\u003Cbr\u003EРиманал ВМ можно применять с другими офтальмологическими препаратами с целью снижения ВГД. При использовании двух и более препаратов необходимо делать 5 минутный перерыв между инстилляциями.\u003Cbr\u003EПрименение Риманал ВМ не изучали у пациентов с нарушением функции печени или почек; при лечении таких пациентов необходимо соблюдать осторожность.\u003Cbr\u003EПрименение у детей\u003Cbr\u003EВ 3-месячном исследовании фазы 3 у детей в возрасте 2-7 лет с глаукомой и с недостаточным контролем заболевания при применении 0-блокаторов отмечали высокую частоту возникновения сонливости (55 %) при применении 0,2 % бримонидина в качестве дополнительной терапии. Сонливость была сильно выражена у 8 % детей и являлась причиной прекращения лечения в 13 % случаев. Частота сонливости снижалась с увеличением возраста и была минимальной у 7-летних детей (25 %), но в большей степени определялась массой тела: сонливость чаще отмечалась у детей с массой ≤20 кг (63 %) по сравнению с детьми с массой \u003E20 кг (25 %).\u003Cbr\u003EБезопасность и эффективность Риманал ВМ у детей младше 2 лет не установлены.\u003Cbr\u003EПрименение у пожилых людей\u003Cbr\u003EУ пожилых людей не отмечали отличий в безопасности или эффективности по сравнению с другими взрослыми пациентами. Сmах и период полувыведения бримонидина были сходными у пожилых (65 лет и старше) и более молодых пациентов взрослой популяции, что демонстрирует отсутствие значимого влияния возраста на системное всасывание и на выведение бримонидина."},{"name":"Побочные действия","value":"Наиболее часто встречаемыми нежелательными реакциями со стороны органа зрения являются аллергический конъюнктивит, гиперемия конъюнктивы, зуд слизистой оболочки глаз и кожи век. Большинство нежелательных реакций имели быстропроходящий характер и легкую степень тяжести (не требующую прекращения лечения).\u003Cbr\u003EПо данным клинических исследований симптомы аллергических реакций со стороны глаз наблюдались в 12,7 % случаев (являясь причиной прекращения лечения в 11,5 % случаев), при этом у большинства пациентов они проявлялись через 3-6 месяцев применения препарата (согласно актуальной информации об опыте применения препарата Риманал ВМ в концентрации 0,2 %).\u003Cbr\u003EЧастота побочных эффектов, выявленных в ходе исследований, оценивалась следующим образом: очень часто (\u003E10 %), часто (\u003E1 % и \u003C10 %); нечасто (\u003E0,1 % и \u003C1 %), редко (\u003E0,01 % и \u003C0,1 %).\u003Cbr\u003EВ клинических исследованиях препарата Риманал ВМ выявлены следующие побочные эффекты:\u003Cbr\u003EСо стороны органа зрения:\u003Cbr\u003Eочень часто - аллергический конъюнктивит, гиперемия конъюнктивы, зуд слизистой оболочки глаз и кожи век, затуманивание зрения;\u003Cbr\u003Eчасто - ощущение жжения, фолликулез конъюнктивы или фолликулярный конъюнктивит, местные аллергические реакции со стороны глаз (в т.ч. кератоконъюнктивит), нарушение зрения, блефарит, блефароконъюнктивит, катаракта, отек конъюнктивы, кровоизлияние в конъюнктиву, конъюнктивит, ретенционное слезотечение, эпифора, слизистое отделяемое из глаз, сухость и раздражение слизистой оболочки глаз, боль в глазу, отек век, покраснение век, ощущение инородного тела в глазах, кератит, поражения век, фотосенсибилизация, колющее ощущение в глазу, поверхностная точечная кератопатия, слезотечение, выпадение полей зрения, отслойка стекловидного тела, кровоизлияния в стекловидное тело, плавающие помутнения в стекловидном теле и снижение остроты зрения;\u003Cbr\u003Eнечасто - эрозия роговицы, ячмень;\u003Cbr\u003EСо стороны центральной нервной системы:\u003Cbr\u003Eчасто - головная боль, сонливость, бессонница, головокружение;\u003Cbr\u003EСо стороны сердечно-сосудистой системы:\u003Cbr\u003Eчасто - повышение или снижение артериального давления;\u003Cbr\u003EСо стороны органов дыхания:\u003Cbr\u003Eчасто - бронхит, фарингит, кашель, одышка;\u003Cbr\u003Eнечасто - сухость слизистой оболочки носа; апноэ;\u003Cbr\u003EСо стороны желудочно-кишечного тракта:\u003Cbr\u003Eчасто - желудочно-кишечные расстройства - диспепсия, сухость слизистой оболочки полости рта;\u003Cbr\u003EСо стороны кожи и подкожно-жировой клетчатки: часто - сыпь;\u003Cbr\u003EИнфекционные и паразитарные заболевания:\u003Cbr\u003Eчасто - гриппоподобный синдром, инфекционное заболевание (озноб и респираторная инфекция), ринит, синусит, в т.ч. инфекционный;\u003Cbr\u003EЛабораторные показатели:\u003Cbr\u003Eчасто - гиперхолестеринемия;\u003Cbr\u003EДругие: часто - общие аллергические реакции, астения, утомляемость, нарушение вкуса; нечасто - извращение вкуса.\u003Cbr\u003EУ детей (в том числе у новорожденных и грудных детей) отмечено: апноэ, брадикардия, снижение артериального давления (АД), гипотермия, мышечная гипотония, бледность, сонливость, снижение внимания.\u003Cbr\u003EОтдельные серьёзные побочные реакции, такие как возникновение комы, летаргии и угнетения дыхания у новорожденного и грудного ребенка, т.е. в возрасте, в котором использование препарата не одобрено, отмечались при применении препарата в концентрации 0,2 %, превышающей концентрацию данного препарата.\u003Cbr\u003EВ постмаркетинговый период дополнительно получены сообщения о следующих побочных эффектах:\u003Cbr\u003EСо стороны органа зрения: частота неизвестна - ирит, сухой кератоконъюнктивит, миоз;\u003Cbr\u003EСо стороны центральной нервной системы: депрессия, синкопе;\u003Cbr\u003EСо стороны сердечно-сосудистой системы: брадикардия, тахикардия;\u003Cbr\u003EСо стороны желудочно-кишечного тракта: тошнота;\u003Cbr\u003EСо стороны кожи и подкожно-жировой клетчатки: местные кожные реакции (эритема, зуд век, отек лица, сыпь и вазодилатация сосудов кожи век и лица), гиперчувствительность.\u003Cbr\u003EСообщения о подозреваемых нежелательных реакциях\u003Cbr\u003EСообщения о подозреваемых нежелательных реакциях после регистрации лекарственного средства являются важными. При выявлении у пациента серьезной нежелательной реакции на лекарственное средство или появлении новой нежелательной реакции, не описанной в данном разделе, просим проинформировать в соответствии с Национальной системой фармаконадзора."},{"name":"Фармакологическое действие","value":"Риманал ВМ - селективный α2-адреномиметик. Максимальное снижение внутриглазного давления (ВГД) достигается через 2 часа. Гипотензивное действие бримонидина обеспечивается за счет снижения образования и повышения оттока внутриглазной жидкости по увеосклеральному пути."},{"name":"Фармакологическая группа","value":"противоглаукомное средство - альфа 2-адреномиметик селективный"},{"name":"Форма выпуска","value":"капли"},{"name":"Способ применения/введения","value":"местный"},{"name":"Минимальный возраст применения","value":"от 2 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Хранить при температуре не выше 25 °C.\u003Cbr\u003EХранить в недоступном для детей месте!\u003Cbr\u003EПосле вскрытия флакона препарат использовать в течение 28 дней."},{"name":"Передозировка","value":"Передозировка при местном применении\u003Cbr\u003EСимптомы передозировки при местном применении представлены ранее отмеченными нежелательными реакциями.\u003Cbr\u003EПередозировка при случайном проглатывании\u003Cbr\u003EСообщений о случаях передозировки препарата у взрослых достаточно мало.\u003Cbr\u003EНа сегодняшний день зарегистрирована одна нежелательная реакция, связанная со снижением артериального давления (АД). При развитии артериальной гипотензии впоследствии отмечалась рикошетная гипертензия.\u003Cbr\u003EПри случайном приеме препарата внутрь возможны следующие симптомы: угнетение центральной нервной системы, сонливость, угнетение и потеря сознания, снижение АД, брадикардия, снижение температуры тела, цианоз кожных покровов, апноэ, астения, рвота, судороги, аритмия, миоз.\u003Cbr\u003EПри выявлении симптомов передозировки необходимо проведение симптоматической терапии, контроль проходимости дыхательных путей.\u003Cbr\u003EПередозировка у детей\u003Cbr\u003EСимптомы передозировки бримонидином наблюдались при лечении врожденной глаукомы или случайном приеме внутрь у детей младшего возраста. В случае развития передозировки требуются поддерживающая и симптоматическая терапия, а также может быть необходима интенсивная терапия с применением интубации. Полное купирование симптомов передозировки бримонидином во всех сообщенных случаях происходило в течение 6-24 часов."},{"name":"Применение при беременности и кормлении грудью","value":"В доклинических исследованиях не выявлено тератогенного влияния на плод. Однако установлено, что бримонидин проникает через плацентарный барьер и в незначительном количестве содержится в плазме крови плода. Контролируемых исследований у беременных женщин не проводилось. В период беременности бримонидин следует применять только в случаях, когда ожидаемая польза для матери превышает возможный риск для плода.\u003Cbr\u003EВ исследованиях на животных установлено, что бримонидин проникает в грудное молоко. На время применения препарата кормление грудью следует прекратить."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Применение препарата Риманал ВМ может сопровождаться эпизодами слабости и сонливости у некоторых пациентов. В том случае, если работа пациента связана с потенциально опасными видами деятельности, вождением автотранспортных средств, его необходимо заранее предупредить о возможном снижении концентрации внимания и скорости психомоторных реакций, и рекомендовать воздержаться от этих видов деятельности."},{"name":"Особые указания","value":"Необходимы тщательное наблюдение и мониторинг состояния пациентов в возрасте от 2 до 7 лет (особенно с массой тела до 20 кг) в связи с высокой частотой встречаемости и выраженности сонливости.\u003Cbr\u003EПри развитии аллергических реакций на препарат Риманал ВМ необходимо прекратить лечение и обратиться к врачу.\u003Cbr\u003EВозможно повышение внутриглазного давления в случае развития реакций замедленной гиперчувствительности.\u003Cbr\u003EСообщалось о случаях бактериального кератита при использовании многодозовых флаконов офтальмологических средств для местного применения, инфицированных пациентами, которые, в большинстве случаев, имели сопутствующее заболевание роговицы или сопутствующее поражение эпителия роговицы и конъюнктивы.\u003Cbr\u003EПри неправильном обращении или если наконечник флакона-капельницы соприкасается с глазом или, окружающими глаз структурами, офтальмологические препараты могут инфицироваться бактериями, вызывающими глазные инфекции. Использование инфицированного раствора может привести к серьезному повреждению глаза с последующей потерей зрения. Не использовать раствор после истечения срока годности, указанного на флаконе.\u003Cbr\u003EЕсли была перенесена офтальмологическая операция или возникло сопутствующее глазное заболевание (например, травма или инфекция), то следует немедленно проконсультироваться с врачом касательно продолжения использования данного многодозового флакона-капельницы.\u003Cbr\u003EСрок годности препарата после первого вскрытия флакон-капельницы составляет 28 дней. Риманал ВМ содержит бензалкония хлорид, часто используемый в качестве консерванта в офтальмологических лекарственных препаратах. Бензалкония хлорид может вызывать раздражение глаз, точечную кератопатию и/или токсическую язвенную кератопатию, а также абсорбироваться мягкими контактными линзами и обесцвечивать их.\u003Cbr\u003EС осторожностью:\u003Cbr\u003EУ пациентов с почечной недостаточностью (клиренс креатинина ниже 40 мл/мин), печеночной недостаточностью.\u003Cbr\u003EУ пациентов с ортостатической гипотензией, сердечной недостаточностью и недостаточностью мозгового кровообращения, депрессией, синдромом Рейно, облитерирующим тромбангиитом. Бримонидин может усиливать тяжесть течения заболеваний, обусловленных сосудистой недостаточностью. Хотя 0,2 % бримонидин в клинических исследованиях оказывал минимальное влияние и на частоту сердечных сокращений, при лечении пациентов с тяжелыми сердечно-сосудистыми заболеваниями, а также пациентов с нестабильным и неконтролируемым течением сосудистых заболеваний необходимо соблюдать осторожность.\u003Cbr\u003EУ детей в возрасте от 2 до 7 лет."},{"name":"Взаимодействие","value":"Исследований по изучению лекарственного взаимодействия препарата Риманал ВМ не проводилось, однако при его одновременном применении следует учитывать возможность усиления эффекта лекарственных средств, угнетающих центральную нервную систему (алкоголь, барбитураты, производные опия, седативные препараты, общие анестетики). Учитывая способность препаратов группы альфа-адреномиметиков снижать АД и частоту сердечных сокращений (ЧСС), с осторожностью следует одновременно применять гипотензивные лекарственные препараты и сердечные гликозиды.\u003Cbr\u003EВ связи с известным уменьшением выраженности гипотензивного эффекта клонидина (α2- адреномиметик) при совместном применении с трициклическими антидепрессантами, нельзя исключить возможного снижения эффективности препарата Риманал ВМ при сопутствующем лечении трициклическими антидепрессантами.\u003Cbr\u003EС осторожностью следует применять препарат Риманал ВМ с трициклическими антидепрессантами, которые могут оказывать влияние на метаболизм аминов и их распределение в сосудистом русле."},{"name":"Регистрационный номер","value":"ЛП-006370"},{"name":"Дата государственной регистрации","value":"27.07.2020"},{"name":"Владелец регистрационного удостоверения","value":"World Medicine Ilac San Ve Tic"},{"name":"Изготовитель","value":"World Medicine Ilac San ve Tic"},{"name":"Страна бренда","value":"Турция"},{"name":"Страна-производитель","value":"Турция"},{"name":"Срок годности","value":"1 г."}]}],"transitionId":"tr_17346072024155176339"}}}}
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525 ₽

  • 11-13 июня, самовывоз • 0 ₽
POLZAru
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  • Диклофенак гл. капли, 0.1%, 5 мл, 1 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-wcei95mugxh/toggleWishlist":{"skuId":"228007759","productId":1778174347,"offerId":"VoXOaebpVATpmXLN8Km3bg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQyM7IqNmxzdN0EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIi5PzzwYQz77cbBiKxNkHINzcwQc=","sign":"Cn2+4IKTLEgxYf9bP3Wit9kKvcLH2kjoXMOer+uA8cY="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-wcei95mugxh/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Диклофенак гл. капли, 0.1%, 5 мл, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 4 оценки
    Цена 65 ₽
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  • Бримонидин-СЗ гл. капли фл., 2 мг/мл, 5 мл
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-gkcfdne86f/toggleWishlist":{"skuId":"101828303958","productId":1771808158,"offerId":"MNmbdKBW6j_yqC2dS-qpgw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQyM7IqNmxzdN0EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcInsvuzAYQ1rjCq/sCGK7e0Acg3NzBBw==","sign":"UkSo3bjYKyHDGK7Y50Vv0yXP0ZE2EHLphogBadyh/zI="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-gkcfdne86f/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Бримонидин-СЗ гл. капли фл., 2 мг/мл, 5 мл

    Рейтинг товара: 4.8 из 5
    на основе 35 оценок
    Цена 575 ₽
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  • Максидекс гл. капли фл.-капельница, 0.1%, 5 мл
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    Максидекс гл. капли фл.-капельница, 0.1%, 5 мл

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 480 ₽
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  • Тафлопресс Ромфарм гл. капли фл., 0.015 мг/мл, 2.5 мл
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-92193846osj/toggleWishlist":{"skuId":"676138002","productId":1778174775,"offerId":"1FjJx3ekDhItPAqW8IQImw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQyM7IqNmxzdN0EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIt5bzzwYQkpi0wgIYisTZByDc3MEH","sign":"xpR5N/5gWWKrM9rd6wzzG+EKkPaTjw/OXGoi2wPZG1Q="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-92193846osj/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Тафлопресс Ромфарм гл. капли фл., 0.015 мг/мл, 2.5 мл

    Рейтинг товара: 4.7 из 5
    на основе 22 оценки
    Цена 263 ₽
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  • Инокаин гл. капли, 0.4%, 5 мл
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-8k1n8zulqdt/toggleWishlist":{"skuId":"228042724","productId":1778174359,"offerId":"87O-KFNvNudLLVpJ3RR03Q","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQyM7IqNmxzdN0EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIl5PzzwYQ5M/ebBjovt4HINzcwQc=","sign":"MEVA1nC9NcqUP/EonmjXgIbIX6lebYjwy9okC5/gs1I="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-8k1n8zulqdt/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Инокаин гл. капли, 0.4%, 5 мл

    Рейтинг товара: 5 из 5
    на основе 5 оценок
    Цена 132 ₽
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  • Максифлокс гл. капли фл., 5 мг/мл, 5 мл, 1 шт.
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    Максифлокс гл. капли фл., 5 мг/мл, 5 мл, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 4 оценки
    Цена 172 ₽
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  • Флоас Моно гл. капли, 0.1%, 5 мл
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    Флоас Моно гл. капли, 0.1%, 5 мл

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 440 ₽
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  • Бринекс-М гл. капли, 1%, 5 мл
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    Бринекс-М гл. капли, 1%, 5 мл

    Рейтинг товара: 4.7 из 5
    на основе 10 оценок
    Цена 975 ₽
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  • Олопаталлерг гл. капли, 0.1%, 5 мл
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    Олопаталлерг гл. капли, 0.1%, 5 мл

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 631 ₽
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  • Тимолол-мэз гл. капли, 5 мг/мл, 5 мл, 1 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-gh9du1xp6t7/toggleWishlist":{"skuId":"265151649","productId":1778174414,"offerId":"vWuAlU2Mms98hBwQK9akpQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQyM7IqNmxzdN0EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIzpPzzwYQocm3fhjK3NAHINzcwQc=","sign":"qQ/sfsqoqh6Xr8ArWm7y9Ikn8ADwlKPuX1wlZM3Ufmg="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-gh9du1xp6t7/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Тимолол-мэз гл. капли, 5 мг/мл, 5 мл, 1 шт.

    Рейтинг товара: 4.8 из 5
    на основе 4 оценки
    Цена 39 ₽
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Инструкция

Показания к применению

Открытоугольная глаукома. Офтальмогипертензия (в монотерапии или в комбинации с другими препаратами, снижающими внутриглазное давление (ВГД)).

Противопоказания

Одновременная терапия ингибиторами монооксидазы;
гиперчувствительность к бримонидину и другим компонентам препарата;
период грудного вскармливания;
детский возраст до 2 лет.

Способ применения и дозы

Местно.
В конъюнктивальный мешок пораженного глаза по 1 капле 3 раза в сутки с интервалом между введениями около 8 ч.
Для снижения системной экспозиции препарата сразу после закапывания рекомендуется надавить на область слезного мешка у внутреннего угла глаза (закрывая слезную точку) в течение 1 минуты.
Риманал ВМ можно применять с другими офтальмологическими препаратами с целью снижения ВГД. При использовании двух и более препаратов необходимо делать 5 минутный перерыв между инстилляциями.
Применение Риманал ВМ не изучали у пациентов с нарушением функции печени или почек; при лечении таких пациентов необходимо соблюдать осторожность.
Применение у детей
В 3-месячном исследовании фазы 3 у детей в возрасте 2-7 лет с глаукомой и с недостаточным контролем заболевания при применении 0-блокаторов отмечали высокую частоту возникновения сонливости (55 %) при применении 0,2 % бримонидина в качестве дополнительной терапии. Сонливость была сильно выражена у 8 % детей и являлась причиной прекращения лечения в 13 % случаев. Частота сонливости снижалась с увеличением возраста и была минимальной у 7-летних детей (25 %), но в большей степени определялась массой тела: сонливость чаще отмечалась у детей с массой ≤20 кг (63 %) по сравнению с детьми с массой >20 кг (25 %).
Безопасность и эффективность Риманал ВМ у детей младше 2 лет не установлены.
Применение у пожилых людей
У пожилых людей не отмечали отличий в безопасности или эффективности по сравнению с другими взрослыми пациентами. Сmах и период полувыведения бримонидина были сходными у пожилых (65 лет и старше) и более молодых пациентов взрослой популяции, что демонстрирует отсутствие значимого влияния возраста на системное всасывание и на выведение бримонидина.
Полная инструкция
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Риманал ВМ капли гл. фл.
Риманал ВМ капли гл. фл., 1.5 мг/мл, 5 мл
5.0
(1)
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Задать вопрос
Инструкция

525 ₽

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5.0
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