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Описание

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Моксарел таб. п/о плен., 0.2 мг, 60 шт.

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5.0
(2)
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Дозировка: 0.2 мг

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Количество штук в упаковке, шт.: 60

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Коротко о товаре

Артикул Маркета
3579608698
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
{"widgets":{"@card/SpecsList":{"/content/page/fancyPage/productSpecsList":{"wrapperProps":{"margins":{"top":4,"bottom":4}},"specsLimit":5,"title":"Коротко о товаре","titleSize":"14","type":"minimal","offset":"s","isHealthCategory":true,"forceShowWidget":true,"withFridge":true}}},"meta":{"/content/page/fancyPage/productSpecsList":{"name":"@card/SpecsList"}},"collections":{"minimalSpecs":{"18391007478471545141":{"specItems":[{"name":"Артикул Маркета","value":"3579608698","withCopyValueButton":true},{"name":"тип препарата","value":"рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"назначение","value":"артериальная гипертензия, гипертония","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["36476390:36619024,36618511"]}}},{"name":"действующее вещество","value":"Моксонидин","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["27144131:28709517"]}}},{"name":"возраст","value":"от 18 лет"},{"name":"форма выпуска","value":"таблетки"},{"name":"страна-производитель","value":"Россия"}]}},"compactSpecs":{"18391007478471545141":{"specItems":[{"name":"Артикул Маркета","value":"3579608698","withCopyValueButton":true},{"name":"Тип препарата","value":"Рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"Назначение","value":"Артериальная гипертензия, гипертония","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["36476390:36619024,36618511"]}}},{"name":"Действующее вещество","value":"Моксонидин","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["27144131:28709517"]}}},{"name":"Возраст","value":"От 18 лет"}]}},"fullSpecs":{"18391007478471545141":{"specItems":[{"name":"Тип препарата","value":"лекарственный препарат","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["34324371:35649313"]}}},{"name":"Рецептурный препарат","value":"да","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["27272850:1,0"]}}},{"name":"Органы и системы","value":"кровеносные сосуды, сердце"},{"name":"Назначение","value":"артериальная гипертензия, гипертония","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["36476390:36619024,36618511"]}}},{"name":"Показания к применению","value":"Артериальная гипертензия."},{"name":"Противопоказания","value":"- повышенная чувствительность к активному веществу, другим компонентам препарата;\u003Cbr\u003E- ангионевротический отек в анамнезе;\u003Cbr\u003E- синдром слабости синусового узла;\u003Cbr\u003E- атриовентрикулярная блокада II и III степени;\u003Cbr\u003E- выраженная брадикардия (частота сердечных сокращений (ЧСС) менее 50 уд/мин);\u003Cbr\u003E- острая и хроническая сердечная недостаточность (III-IV функциональный класс по классификации NYHA);\u003Cbr\u003E- тяжелая почечная недостаточность (КК менее 30 мл/мин), включая пациентов, находящихся на гемодиализе;\u003Cbr\u003E- возраст до 18 лет (эффективность и безопасность моксонидина не установлены);\u003Cbr\u003E- период грудного вскармливания;\u003Cbr\u003E- непереносимость лактозы, дефицит лактазы, глюкозо-галактозная мальабсорбция."},{"name":"Состав","value":"Одна таблетка, покрытая пленочной оболочкой, содержит:\u003Cbr\u003EДозировка 0,2 мг\u003Cbr\u003Eдействующее вещество: моксонидин - 0,20 мг;\u003Cbr\u003Eвспомогательные вещества: лактозы моногидрат - 64,00 мг, целлюлоза микрокристаллическая - 29,80 мг, повидон К-30 - 2,00 мг, кроскармеллоза натрия - 2,0 мг, кремния диоксид коллоидный - 1,00 мг, магния стеарат - 1,00 мг.\u003Cbr\u003EПленочная оболочка: [гипромеллоза - 1,80 мг, тальк - 0,60 мг, титана диоксид - 0.33 мг, макрогол 4000 (полиэтиленгликоль 4000) - 0,27 мг] или [сухая смесь для пленочного покрытия, содержащая гипромеллозу (60%), тальк (20%), титана диоксид (11%), макрогол 4000 (полиэтиленгликоль 4000) (9%)] - 3,00 мг.\u003Cbr\u003EДозировка 0,3 мг\u003Cbr\u003Eдействующее вещество: моксонидин - 0,30 мг;\u003Cbr\u003Eвспомогательные вещества: лактозы моногидрат - 64,00 мг, целлюлоза микрокристаллическая - 29,70 мг, повидон К-30 - 2,00 мг, кроскармеллоза натрия - 2,0 мг, кремния диоксид коллоидный - 1,00 мг, магния стеарат - 1,00 мг.\u003Cbr\u003EПленочная оболочка: [гипромеллоза - 1,80 мг, тальк - 0,60 мг, титана диоксид - 0.31 мг, макрогол 4000 (полиэтиленгликоль 4000) - 0,27 мг, железа оксид красный (железа оксид) - 0,02 мг] или [сухая смесь для пленочного покрытия, содержащая гипромеллозу (60%), тальк (20%), титана диоксид (10,33%), макрогол 4000 (полиэтиленгликоль 4000) (9%), железа оксид красный (железа оксид) (0,67%)] - 3,00 мг.\u003Cbr\u003EДозировка 0,4 мг\u003Cbr\u003Eдействующее вещество: моксонидин - 0,40 мг;\u003Cbr\u003Eвспомогательные вещества: лактозы моногидрат - 64,00 мг, целлюлоза микрокристаллическая - 29,60 мг, повидон К-30 - 2,00 мг, кроскармеллоза натрия - 2,0 мг, кремния диоксид коллоидный - 1,00 мг, магния стеарат - 1,00 мг.\u003Cbr\u003EПленочная оболочка: [гипромеллоза - 1,80 мг, тальк - 0,60 мг, титана диоксид - 0,31 мг, макрогол 4000 (полиэтиленгликоль 4000) - 0,27 мг, железа оксид желтый (железа оксид) - 0,02 мг] или [сухая смесь для пленочного покрытия, содержащая гипромеллозу (60%), тальк (20%), титана диоксид (10,33%), макрогол 4000 (полиэтиленгликоль 4000) (9%), железа оксид желтый (железа оксид) (0,67%)] - 3,00 мг."},{"name":"Действующее вещество","value":"Моксонидин","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["27144131:28709517"]}}},{"name":"Способ применения и дозы","value":"Внутрь, независимо от приема пищи.\u003Cbr\u003EВ большинстве случаев начальная доза препарата Моксарел® составляет 0,2 мг в сутки. Максимальная разовая доза составляет 0,4 мг. Максимальная суточная доза, которую следует разделить на 2 приема, составляет 0,6 мг.\u003Cbr\u003EНеобходима индивидуальная коррекция суточной дозы в зависимости от переносимости пациентом проводимой терапии.\u003Cbr\u003EКоррекция дозы для пациентов с печеночной недостаточностью не требуется.\u003Cbr\u003EНачальная доза для пациентов находящихся на гемодиализе, составляет 0,2 мг/сутки. В случае необходимости и при хорошей переносимости суточная доза может быть увеличена до 0,4 мг.\u003Cbr\u003EПациентам с почечной недостаточностью рекомендуется осторожный подбор дозы, особенно в начале лечения. Начальная доза должна составлять 0.2 мг в сутки. В случае необходимости и при хорошей переносимости суточная доза препарата может быть увеличена максимум до 0,4 мг для пациентов с умеренной почечной недостаточностью (КК более 30 мл/мин, но менее 60 мл/мин) и 0,3 мг для пациентов с тяжелой почечной недостаточностью (КК менее 30 мл/мин)."},{"name":"Побочные действия","value":"Наиболее частые побочные явления у пациентов, принимающих моксонидин; сухость во рту, головокружение, астения, сонливость. Эти симптомы часто уменьшаются по прошествии первых недель терапии.\u003Cbr\u003EКлассификация частоты развития побочных эффектов согласно рекомендациям\u003Cbr\u003EВсемирной организации здравоохранения (ВОЗ):\u003Cbr\u003Eочень часто ≥ 1/10;\u003Cbr\u003Eчасто от ≥ 1/100 до \u003C 1/10;\u003Cbr\u003Eнечасто от ≥ 1/1000 до \u003C 1/100;\u003Cbr\u003Eредко от ≥ 1/10000 до \u003C 1/1000;\u003Cbr\u003Eочень редко \u003C 1/10000, включая отдельные сообщения;\u003Cbr\u003Eчастота неизвестна - по имеющимся данным установить частоту возникновения не представляется возможным.\u003Cbr\u003EНарушения со стороны нервной системы:\u003Cbr\u003Eчасто - головная боль*, головокружение (вертиго), сонливость, бессонница;\u003Cbr\u003Eнечасто - обморок*, повышенная возбудимость.\u003Cbr\u003EНарушения со стороны сердца:\u003Cbr\u003Eнечасто - выраженное снижение АД, ортостатическая гипотензия, брадикардия.\u003Cbr\u003EНарушения со стороны органа слуха и лабиринта:\u003Cbr\u003Eнечасто - звон в ушах.\u003Cbr\u003EЖелудочно-кишечные нарушения:\u003Cbr\u003Eочень часто - сухость слизистой оболочки полости рта;\u003Cbr\u003Eчасто - тошнота, диарея, рвота, диспепсия.\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей:\u003Cbr\u003Eчасто - кожная сыпь, зуд;\u003Cbr\u003Eнечасто - ангионевротический отек.\u003Cbr\u003EНарушения со стороны мышечной, скелетной и соединительной ткани:\u003Cbr\u003Eчасто - боль в спине;\u003Cbr\u003Eнечасто - боль в области шеи.\u003Cbr\u003EОбщие нарушения и реакции в месте введения:\u003Cbr\u003Eчасто - астения;\u003Cbr\u003Eнечасто - периферические отеки.\u003Cbr\u003E* частота сопоставима с плацебо"},{"name":"Фармакологическое действие","value":"Моксонидин является гипотензивным средством с центральным механизмом действия. В стволовых структурах мозга (ростральный слой боковых желудочков) моксонидин селективно стимулирует имидазолин-чувствительные рецепторы, принимающие участие в тонической и рефлекторной регуляции симпатической нервной системы. Стимуляция имидазолиновых рецепторов снижает периферическую симпатическую активность и артериальное давление (АД).\u003Cbr\u003EМоксонидин отличается от других симпатолитических гипотензивных средств более низким сродством к α2-адренорецепторам, что объясняет меньшую вероятность развития седативного эффекта и сухости слизистой оболочки полости рта.\u003Cbr\u003EПрием моксонидина приводит к снижению системного сосудистого сопротивления и АД. Гипотензивный эффект моксонидина подтвержден в двойных слепых плацебо-контролируемых рандомизированных исследованиях.\u003Cbr\u003EРезультаты клинического исследования с участием 42 пациентов с артериальной гипертензией и гипертрофией левого желудочка (ГЛЖ) продемонстрировали, что при сходном снижении артериального давления, применение комбинации антагонистов рецепторов к ангиотензину II с моксонидином позволяет в большей степени уменьшить ГЛЖ по сравнению со свободной комбинацией тиазидного диуретика и блокатора кальциевых каналов (15% против 11%; р \u003C 0,5).\u003Cbr\u003EМоксонидин улучшает на 21% индекс чувствительности к инсулину (в сравнении с плацебо) у пациентов с ожирением, инсулинорезистентностью и умеренной степенью артериальной гипертензии."},{"name":"Фармакологическая группа","value":"гипотензивное средство центрального действия"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"В защищенном от света месте, при температуре не выше 25 °С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Имеются сообщения о нескольких случаях передозировки без летального исхода, когда одновременно применялись дозы до 19,6 мг.\u003Cbr\u003EСимптомы\u003Cbr\u003EГоловная боль, седативный эффект, сонливость, выраженное снижение АД, головокружение, усталость, астения, брадикардия, сухость слизистой оболочки полости рта, рвота и боль в эпигастральной области, угнетение дыхания, нарушение сознания. Кроме того, возможны кратковременное повышение АД, тахикардия, гипергликемия.\u003Cbr\u003EЛечение\u003Cbr\u003EСпецифического антидота не существует. В случае выраженного снижения АД рекомендуется введение жидкости для восстановления объема циркулирующей крови и допамина (инъекционно).\u003Cbr\u003EБрадикардия может быть купирована атропином (инъекционное введение). Антагонисты альфа-адренорецепторов могут уменьшать или устранять парадоксальные гипертензивные эффекты при передозировке моксонидином.\u003Cbr\u003EВ тяжелых случаях передозировки рекомендуется тщательно контролировать нарушения сознания и не допускать угнетения дыхания."},{"name":"Применение при беременности и кормлении грудью","value":"Клинические данные о лечении беременных препаратом Моксарел отсутствуют. Назначать Моксарел беременным следует с осторожностью только после тщательной оценки соотношения риска и пользы, когда польза для матери превышает потенциальный риск для плода.\u003Cbr\u003EМоксонидин проникает в грудное молоко. Кормящим женщинам в период лечения рекомендуется прекратить грудное вскармливание или отменить препарат."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Влияние препарата Моксарел на способность к вождению транспортными средствами или управлению техникой изучено не было. Однако, принимая во внимание возможное возникновение головокружения и сонливости, пациентам следует соблюдать осторожность при занятии потенциально опасными видами деятельности, требующими повышенного внимания, таких как вождение автотранспорта или управление техникой, требующей повышенной концентрации внимания."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003E- Атриовентрикулярная блокада I степени (риск развития брадикардии);\u003Cbr\u003E- заболевания коронарных артерий (в т.ч. ишемическая болезнь сердца, нестабильная стенокардия, ранний постинфарктный период);\u003Cbr\u003E- заболевания переферического кровообращения (в т.ч. перемежающаяся хромота, синдром Рейно);\u003Cbr\u003E- эпилепсия;\u003Cbr\u003E- болезнь Паркинсона;\u003Cbr\u003E- депрессия;\u003Cbr\u003E- глаукома;\u003Cbr\u003E- умеренная почечная недостаточность (КК 30-60 мл/мин, креатинин сыворотки 105-160 мкмоль/л);\u003Cbr\u003E- печеночная недостаточность;\u003Cbr\u003E- беременность.\u003Cbr\u003EВ постмаркетинговом наблюдении зафиксированы случаи атриовентрикулярной блокады различной степени тяжести у пациентов, принимающих моксонидин. Связь между приемом препарата Моксарел и замедлением атриовентрикулярной проводимости не может быть полностью исключена. Таким образом, при лечении пациентов с вероятной предрасположенностью к развитию атриовентрикулярной блокады рекомендуется соблюдать осторожность.\u003Cbr\u003EВ настоящее время нет подтверждений того, что прекращение приема препарата Моксарел приводит к повышению АД. Однако не рекомендуется прекращать прием препарата Моксарел резко, вместо этого следует постепенно уменьшать дозу препарата в течение двух недель.\u003Cbr\u003EПри необходимости отмены одновременно принимаемых бета-адреноблокаторов и препарата Моксарел сначала отменяют бета-адреноблокаторы, и лишь через несколько дней моксонидин.\u003Cbr\u003EУ пациентов пожилого возраста может быть повышен риск развития сердечно-сосудистых осложнений вследствие применения гипотензивных препаратов, поэтому терапию препаратом Моксарел следует начинанать с минимальной дозы.\u003Cbr\u003EВо время лечения необходим регулярный контроль АД, ЧСС и регистрация электрокардиографии (ЭКГ). Прекращать прием препарата Моксарел следует постепенно.\u003Cbr\u003EВо время лечения препаратом Моксарел следует исключить употребление алкоголя."},{"name":"Взаимодействие","value":"Совместное применение моксонидина с другими гипотензивными средствами приводит к аддитивному эффекту.\u003Cbr\u003EТрициклические антидепрессанты могут снижать эффективность гипотензивных средств центрального действия, в связи с чем не рекомендуется их прием совместно с моксонидином.\u003Cbr\u003EМоксонидин может усиливать действие трициклических антидепрессантов, транквилизаторов, этанола, седативных и снотворных средств.\u003Cbr\u003EМоксонидин способен умеренно улучшать ослабленные когнитивные функции у пациентов, получающих лоразепам.\u003Cbr\u003EНазначение моксонидина совместно с производными бензодиазепина может сопровождаться усилением седативного эффекта последних.\u003Cbr\u003EМоксонидин выделяется путем канальцевой секреции, поэтому не исключено его взаимодействие с другими препаратами, выделяющимися путем канальцевой секреции."},{"name":"Источник","value":"\u003Ca href=\"https://www.vidal.ru\" target=\"_blank\"\u003EСправочник лекарственных препаратов Видаль<\u002Fa\u003E"},{"name":"Регистрационный номер","value":"ЛП-002550"},{"name":"Дата государственной регистрации","value":"01.08.2019"},{"name":"Владелец регистрационного удостоверения","value":"Вертекс","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["34324371:35649313","7893318:8514228"]}}},{"name":"Изготовитель","value":"Вертекс"},{"name":"Фасовщик","value":"Вертекс"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Моксарел","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["17796364:18017701"]}}},{"name":"Срок годности","value":"781 дн."}]}},"fullSpecsGrouped":{"18391007478471545141":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"кровеносные сосуды, сердце"},{"name":"Назначение","value":"артериальная гипертензия, гипертония"},{"name":"Показания к применению","value":"Артериальная гипертензия."},{"name":"Противопоказания","value":"- повышенная чувствительность к активному веществу, другим компонентам препарата;\u003Cbr\u003E- ангионевротический отек в анамнезе;\u003Cbr\u003E- синдром слабости синусового узла;\u003Cbr\u003E- атриовентрикулярная блокада II и III степени;\u003Cbr\u003E- выраженная брадикардия (частота сердечных сокращений (ЧСС) менее 50 уд/мин);\u003Cbr\u003E- острая и хроническая сердечная недостаточность (III-IV функциональный класс по классификации NYHA);\u003Cbr\u003E- тяжелая почечная недостаточность (КК менее 30 мл/мин), включая пациентов, находящихся на гемодиализе;\u003Cbr\u003E- возраст до 18 лет (эффективность и безопасность моксонидина не установлены);\u003Cbr\u003E- период грудного вскармливания;\u003Cbr\u003E- непереносимость лактозы, дефицит лактазы, глюкозо-галактозная мальабсорбция."},{"name":"Состав","value":"Одна таблетка, покрытая пленочной оболочкой, содержит:\u003Cbr\u003EДозировка 0,2 мг\u003Cbr\u003Eдействующее вещество: моксонидин - 0,20 мг;\u003Cbr\u003Eвспомогательные вещества: лактозы моногидрат - 64,00 мг, целлюлоза микрокристаллическая - 29,80 мг, повидон К-30 - 2,00 мг, кроскармеллоза натрия - 2,0 мг, кремния диоксид коллоидный - 1,00 мг, магния стеарат - 1,00 мг.\u003Cbr\u003EПленочная оболочка: [гипромеллоза - 1,80 мг, тальк - 0,60 мг, титана диоксид - 0.33 мг, макрогол 4000 (полиэтиленгликоль 4000) - 0,27 мг] или [сухая смесь для пленочного покрытия, содержащая гипромеллозу (60%), тальк (20%), титана диоксид (11%), макрогол 4000 (полиэтиленгликоль 4000) (9%)] - 3,00 мг.\u003Cbr\u003EДозировка 0,3 мг\u003Cbr\u003Eдействующее вещество: моксонидин - 0,30 мг;\u003Cbr\u003Eвспомогательные вещества: лактозы моногидрат - 64,00 мг, целлюлоза микрокристаллическая - 29,70 мг, повидон К-30 - 2,00 мг, кроскармеллоза натрия - 2,0 мг, кремния диоксид коллоидный - 1,00 мг, магния стеарат - 1,00 мг.\u003Cbr\u003EПленочная оболочка: [гипромеллоза - 1,80 мг, тальк - 0,60 мг, титана диоксид - 0.31 мг, макрогол 4000 (полиэтиленгликоль 4000) - 0,27 мг, железа оксид красный (железа оксид) - 0,02 мг] или [сухая смесь для пленочного покрытия, содержащая гипромеллозу (60%), тальк (20%), титана диоксид (10,33%), макрогол 4000 (полиэтиленгликоль 4000) (9%), железа оксид красный (железа оксид) (0,67%)] - 3,00 мг.\u003Cbr\u003EДозировка 0,4 мг\u003Cbr\u003Eдействующее вещество: моксонидин - 0,40 мг;\u003Cbr\u003Eвспомогательные вещества: лактозы моногидрат - 64,00 мг, целлюлоза микрокристаллическая - 29,60 мг, повидон К-30 - 2,00 мг, кроскармеллоза натрия - 2,0 мг, кремния диоксид коллоидный - 1,00 мг, магния стеарат - 1,00 мг.\u003Cbr\u003EПленочная оболочка: [гипромеллоза - 1,80 мг, тальк - 0,60 мг, титана диоксид - 0,31 мг, макрогол 4000 (полиэтиленгликоль 4000) - 0,27 мг, железа оксид желтый (железа оксид) - 0,02 мг] или [сухая смесь для пленочного покрытия, содержащая гипромеллозу (60%), тальк (20%), титана диоксид (10,33%), макрогол 4000 (полиэтиленгликоль 4000) (9%), железа оксид желтый (железа оксид) (0,67%)] - 3,00 мг."},{"name":"Действующее вещество","value":"Моксонидин"},{"name":"Способ применения и дозы","value":"Внутрь, независимо от приема пищи.\u003Cbr\u003EВ большинстве случаев начальная доза препарата Моксарел® составляет 0,2 мг в сутки. Максимальная разовая доза составляет 0,4 мг. Максимальная суточная доза, которую следует разделить на 2 приема, составляет 0,6 мг.\u003Cbr\u003EНеобходима индивидуальная коррекция суточной дозы в зависимости от переносимости пациентом проводимой терапии.\u003Cbr\u003EКоррекция дозы для пациентов с печеночной недостаточностью не требуется.\u003Cbr\u003EНачальная доза для пациентов находящихся на гемодиализе, составляет 0,2 мг/сутки. В случае необходимости и при хорошей переносимости суточная доза может быть увеличена до 0,4 мг.\u003Cbr\u003EПациентам с почечной недостаточностью рекомендуется осторожный подбор дозы, особенно в начале лечения. Начальная доза должна составлять 0.2 мг в сутки. В случае необходимости и при хорошей переносимости суточная доза препарата может быть увеличена максимум до 0,4 мг для пациентов с умеренной почечной недостаточностью (КК более 30 мл/мин, но менее 60 мл/мин) и 0,3 мг для пациентов с тяжелой почечной недостаточностью (КК менее 30 мл/мин)."},{"name":"Побочные действия","value":"Наиболее частые побочные явления у пациентов, принимающих моксонидин; сухость во рту, головокружение, астения, сонливость. Эти симптомы часто уменьшаются по прошествии первых недель терапии.\u003Cbr\u003EКлассификация частоты развития побочных эффектов согласно рекомендациям\u003Cbr\u003EВсемирной организации здравоохранения (ВОЗ):\u003Cbr\u003Eочень часто ≥ 1/10;\u003Cbr\u003Eчасто от ≥ 1/100 до \u003C 1/10;\u003Cbr\u003Eнечасто от ≥ 1/1000 до \u003C 1/100;\u003Cbr\u003Eредко от ≥ 1/10000 до \u003C 1/1000;\u003Cbr\u003Eочень редко \u003C 1/10000, включая отдельные сообщения;\u003Cbr\u003Eчастота неизвестна - по имеющимся данным установить частоту возникновения не представляется возможным.\u003Cbr\u003EНарушения со стороны нервной системы:\u003Cbr\u003Eчасто - головная боль*, головокружение (вертиго), сонливость, бессонница;\u003Cbr\u003Eнечасто - обморок*, повышенная возбудимость.\u003Cbr\u003EНарушения со стороны сердца:\u003Cbr\u003Eнечасто - выраженное снижение АД, ортостатическая гипотензия, брадикардия.\u003Cbr\u003EНарушения со стороны органа слуха и лабиринта:\u003Cbr\u003Eнечасто - звон в ушах.\u003Cbr\u003EЖелудочно-кишечные нарушения:\u003Cbr\u003Eочень часто - сухость слизистой оболочки полости рта;\u003Cbr\u003Eчасто - тошнота, диарея, рвота, диспепсия.\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей:\u003Cbr\u003Eчасто - кожная сыпь, зуд;\u003Cbr\u003Eнечасто - ангионевротический отек.\u003Cbr\u003EНарушения со стороны мышечной, скелетной и соединительной ткани:\u003Cbr\u003Eчасто - боль в спине;\u003Cbr\u003Eнечасто - боль в области шеи.\u003Cbr\u003EОбщие нарушения и реакции в месте введения:\u003Cbr\u003Eчасто - астения;\u003Cbr\u003Eнечасто - периферические отеки.\u003Cbr\u003E* частота сопоставима с плацебо"},{"name":"Фармакологическое действие","value":"Моксонидин является гипотензивным средством с центральным механизмом действия. В стволовых структурах мозга (ростральный слой боковых желудочков) моксонидин селективно стимулирует имидазолин-чувствительные рецепторы, принимающие участие в тонической и рефлекторной регуляции симпатической нервной системы. Стимуляция имидазолиновых рецепторов снижает периферическую симпатическую активность и артериальное давление (АД).\u003Cbr\u003EМоксонидин отличается от других симпатолитических гипотензивных средств более низким сродством к α2-адренорецепторам, что объясняет меньшую вероятность развития седативного эффекта и сухости слизистой оболочки полости рта.\u003Cbr\u003EПрием моксонидина приводит к снижению системного сосудистого сопротивления и АД. Гипотензивный эффект моксонидина подтвержден в двойных слепых плацебо-контролируемых рандомизированных исследованиях.\u003Cbr\u003EРезультаты клинического исследования с участием 42 пациентов с артериальной гипертензией и гипертрофией левого желудочка (ГЛЖ) продемонстрировали, что при сходном снижении артериального давления, применение комбинации антагонистов рецепторов к ангиотензину II с моксонидином позволяет в большей степени уменьшить ГЛЖ по сравнению со свободной комбинацией тиазидного диуретика и блокатора кальциевых каналов (15% против 11%; р \u003C 0,5).\u003Cbr\u003EМоксонидин улучшает на 21% индекс чувствительности к инсулину (в сравнении с плацебо) у пациентов с ожирением, инсулинорезистентностью и умеренной степенью артериальной гипертензии."},{"name":"Фармакологическая группа","value":"гипотензивное средство центрального действия"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"В защищенном от света месте, при температуре не выше 25 °С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Имеются сообщения о нескольких случаях передозировки без летального исхода, когда одновременно применялись дозы до 19,6 мг.\u003Cbr\u003EСимптомы\u003Cbr\u003EГоловная боль, седативный эффект, сонливость, выраженное снижение АД, головокружение, усталость, астения, брадикардия, сухость слизистой оболочки полости рта, рвота и боль в эпигастральной области, угнетение дыхания, нарушение сознания. Кроме того, возможны кратковременное повышение АД, тахикардия, гипергликемия.\u003Cbr\u003EЛечение\u003Cbr\u003EСпецифического антидота не существует. В случае выраженного снижения АД рекомендуется введение жидкости для восстановления объема циркулирующей крови и допамина (инъекционно).\u003Cbr\u003EБрадикардия может быть купирована атропином (инъекционное введение). Антагонисты альфа-адренорецепторов могут уменьшать или устранять парадоксальные гипертензивные эффекты при передозировке моксонидином.\u003Cbr\u003EВ тяжелых случаях передозировки рекомендуется тщательно контролировать нарушения сознания и не допускать угнетения дыхания."},{"name":"Применение при беременности и кормлении грудью","value":"Клинические данные о лечении беременных препаратом Моксарел отсутствуют. Назначать Моксарел беременным следует с осторожностью только после тщательной оценки соотношения риска и пользы, когда польза для матери превышает потенциальный риск для плода.\u003Cbr\u003EМоксонидин проникает в грудное молоко. Кормящим женщинам в период лечения рекомендуется прекратить грудное вскармливание или отменить препарат."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Влияние препарата Моксарел на способность к вождению транспортными средствами или управлению техникой изучено не было. Однако, принимая во внимание возможное возникновение головокружения и сонливости, пациентам следует соблюдать осторожность при занятии потенциально опасными видами деятельности, требующими повышенного внимания, таких как вождение автотранспорта или управление техникой, требующей повышенной концентрации внимания."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003E- Атриовентрикулярная блокада I степени (риск развития брадикардии);\u003Cbr\u003E- заболевания коронарных артерий (в т.ч. ишемическая болезнь сердца, нестабильная стенокардия, ранний постинфарктный период);\u003Cbr\u003E- заболевания переферического кровообращения (в т.ч. перемежающаяся хромота, синдром Рейно);\u003Cbr\u003E- эпилепсия;\u003Cbr\u003E- болезнь Паркинсона;\u003Cbr\u003E- депрессия;\u003Cbr\u003E- глаукома;\u003Cbr\u003E- умеренная почечная недостаточность (КК 30-60 мл/мин, креатинин сыворотки 105-160 мкмоль/л);\u003Cbr\u003E- печеночная недостаточность;\u003Cbr\u003E- беременность.\u003Cbr\u003EВ постмаркетинговом наблюдении зафиксированы случаи атриовентрикулярной блокады различной степени тяжести у пациентов, принимающих моксонидин. Связь между приемом препарата Моксарел и замедлением атриовентрикулярной проводимости не может быть полностью исключена. Таким образом, при лечении пациентов с вероятной предрасположенностью к развитию атриовентрикулярной блокады рекомендуется соблюдать осторожность.\u003Cbr\u003EВ настоящее время нет подтверждений того, что прекращение приема препарата Моксарел приводит к повышению АД. Однако не рекомендуется прекращать прием препарата Моксарел резко, вместо этого следует постепенно уменьшать дозу препарата в течение двух недель.\u003Cbr\u003EПри необходимости отмены одновременно принимаемых бета-адреноблокаторов и препарата Моксарел сначала отменяют бета-адреноблокаторы, и лишь через несколько дней моксонидин.\u003Cbr\u003EУ пациентов пожилого возраста может быть повышен риск развития сердечно-сосудистых осложнений вследствие применения гипотензивных препаратов, поэтому терапию препаратом Моксарел следует начинанать с минимальной дозы.\u003Cbr\u003EВо время лечения необходим регулярный контроль АД, ЧСС и регистрация электрокардиографии (ЭКГ). Прекращать прием препарата Моксарел следует постепенно.\u003Cbr\u003EВо время лечения препаратом Моксарел следует исключить употребление алкоголя."},{"name":"Взаимодействие","value":"Совместное применение моксонидина с другими гипотензивными средствами приводит к аддитивному эффекту.\u003Cbr\u003EТрициклические антидепрессанты могут снижать эффективность гипотензивных средств центрального действия, в связи с чем не рекомендуется их прием совместно с моксонидином.\u003Cbr\u003EМоксонидин может усиливать действие трициклических антидепрессантов, транквилизаторов, этанола, седативных и снотворных средств.\u003Cbr\u003EМоксонидин способен умеренно улучшать ослабленные когнитивные функции у пациентов, получающих лоразепам.\u003Cbr\u003EНазначение моксонидина совместно с производными бензодиазепина может сопровождаться усилением седативного эффекта последних.\u003Cbr\u003EМоксонидин выделяется путем канальцевой секреции, поэтому не исключено его взаимодействие с другими препаратами, выделяющимися путем канальцевой секреции."},{"name":"Источник","value":"\u003Ca href=\"https://www.vidal.ru\" target=\"_blank\"\u003EСправочник лекарственных препаратов Видаль<\u002Fa\u003E"},{"name":"Регистрационный номер","value":"ЛП-002550"},{"name":"Дата государственной регистрации","value":"01.08.2019"},{"name":"Владелец регистрационного удостоверения","value":"Вертекс"},{"name":"Изготовитель","value":"Вертекс"},{"name":"Фасовщик","value":"Вертекс"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Моксарел"},{"name":"Срок годности","value":"781 дн."}]}],"transitionId":"tr_16286027103891727636"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

Где купить

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503 ₽

Скидка: 21%
–21 %
Вместо:636 ₽
  • 11-13 июня, самовывоз • 0 ₽
POLZAru
Рейтинг 4.9 из 5
38Котзывов
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    Моксонидин Канон таб. п/о плен., 0.4 мг, 28 шт.

    Рейтинг товара: 4.7 из 5
    на основе 23 оценки
    Цена 216 ₽
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  • Моксонитекс таб. п/о плен., 0.2 мг, 28 шт.
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    Моксонитекс таб. п/о плен., 0.2 мг, 28 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 319 ₽
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  • Моксонидин таб. п/о плен., 0.2 мг, 14 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ycrcpngdt5g/toggleWishlist":{"skuId":"228052574","productId":1401075651,"offerId":"Bfs2xETKc8qIaMQWqYOUeA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQqKuq1POK47NLEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIw++KnAUQ3pzfbBiEqbIIINfcwQc=","sign":"Eq6UV423Sie4OT0i53Cy/N2zbwreMEO7/MkvhnVxKP0="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ycrcpngdt5g/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Моксонидин таб. п/о плен., 0.2 мг, 14 шт.

    Рейтинг товара: 5 из 5
    на основе 30 оценок
    Цена 148 ₽
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  • Физиотенз таб. п/о плен., 0.2 мг, 14 шт.
    –13 %
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    Физиотенз таб. п/о плен., 0.2 мг, 14 шт.

    Рейтинг товара: 4.9 из 5
    на основе 8 оценок
    Цена 343 ₽ вместо 393
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  • Лотонел таб., 10 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-iis1gi80n6/toggleWishlist":{"skuId":"228047649","productId":1401075748,"offerId":"CkaPzYk9w4IeWiDcAO--tg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQqKuq1POK47NLEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIpPCKnAUQofbebBi01YcEINfcwQc=","sign":"B2qyjHp4QQDe17TKOr3/sHNRMts1uVqROmzOigpXSp4="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-iis1gi80n6/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Лотонел таб., 10 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 544 ₽
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  • Моксонидин таб. п/о плен., 0.4 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-7nxwwr6cm3r/toggleWishlist":{"skuId":"101872314826","productId":1784965285,"offerId":"Q6cpc41UW3lkQGTNipywHg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQqKuq1POK47NLEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIpdGR0wYQytPAwPsCGJe2+wUg19zBBw==","sign":"D6ipbeDGZ30LUdJSdKS7NwcRrwifAlibEIM4mGmUsl4="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-7nxwwr6cm3r/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Моксонидин таб. п/о плен., 0.4 мг, 30 шт.

    Рейтинг товара: 4.8 из 5
    на основе 23 оценки
    Цена 239 ₽
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  • Моксонидин-Акрихин таб. п/о плен., 0.2 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-6fmd34hh76p/toggleWishlist":{"skuId":"834997635","productId":1401075967,"offerId":"YCynmt7uRtWY2jjYa8AlDg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQqKuq1POK47NLEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYI//GKnAUQg5uUjgMYntShBSDX3MEH","sign":"0KqOLgLOmWS/kpTp45WaZ+z7+dyz6i13SMregUBCbDs="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-6fmd34hh76p/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Моксонидин-Акрихин таб. п/о плен., 0.2 мг, 30 шт.

    Рейтинг товара: 4.8 из 5
    на основе 6 оценок
    Цена 249 ₽
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  • Моксонидин Авексима таб. п/о плен., 0.2 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-mxrkzmy1s3/toggleWishlist":{"skuId":"101392286737","productId":664975014,"offerId":"72zz_9k4YDjBbIX2EojDtw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQqKuq1POK47NLEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIpu2KvQIQkYjO2/kCGNSp2Acg19zBBw==","sign":"cqoJN7cFrYAaeh9D1gkEome4VHz0k3dCsa22FO+/ev0="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-mxrkzmy1s3/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Моксонидин Авексима таб. п/о плен., 0.2 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 7 оценок
    Цена 281 ₽
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  • Лерканорм таб. п/о плен., 10 мг, 30 шт.
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    Лерканорм таб. п/о плен., 10 мг, 30 шт.

    Рейтинг товара: 4.9 из 5
    на основе 11 оценок
    Цена 414 ₽
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Инструкция

Показания к применению

Артериальная гипертензия.

Противопоказания

- повышенная чувствительность к активному веществу, другим компонентам препарата;
- ангионевротический отек в анамнезе;
- синдром слабости синусового узла;
- атриовентрикулярная блокада II и III степени;
- выраженная брадикардия (частота сердечных сокращений (ЧСС) менее 50 уд/мин);
- острая и хроническая сердечная недостаточность (III-IV функциональный класс по классификации NYHA);
- тяжелая почечная недостаточность (КК менее 30 мл/мин), включая пациентов, находящихся на гемодиализе;
- возраст до 18 лет (эффективность и безопасность моксонидина не установлены);
- период грудного вскармливания;
- непереносимость лактозы, дефицит лактазы, глюкозо-галактозная мальабсорбция.

Способ применения и дозы

Внутрь, независимо от приема пищи.
В большинстве случаев начальная доза препарата Моксарел® составляет 0,2 мг в сутки. Максимальная разовая доза составляет 0,4 мг. Максимальная суточная доза, которую следует разделить на 2 приема, составляет 0,6 мг.
Необходима индивидуальная коррекция суточной дозы в зависимости от переносимости пациентом проводимой терапии.
Коррекция дозы для пациентов с печеночной недостаточностью не требуется.
Начальная доза для пациентов находящихся на гемодиализе, составляет 0,2 мг/сутки. В случае необходимости и при хорошей переносимости суточная доза может быть увеличена до 0,4 мг.
Пациентам с почечной недостаточностью рекомендуется осторожный подбор дозы, особенно в начале лечения. Начальная доза должна составлять 0.2 мг в сутки. В случае необходимости и при хорошей переносимости суточная доза препарата может быть увеличена максимум до 0,4 мг для пациентов с умеренной почечной недостаточностью (КК более 30 мл/мин, но менее 60 мл/мин) и 0,3 мг для пациентов с тяжелой почечной недостаточностью (КК менее 30 мл/мин).
Полная инструкция
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Моксарел таб. п/о плен.
Моксарел таб. п/о плен., 0.2 мг, 60 шт.
5.0
(2)
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1 вопрос
Инструкция

503 ₽

Скидка: 21%
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Вместо:636 ₽
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