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Цетиризин таб. п/о плен., 10 мг, 30 шт.

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5.0
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Количество штук/доз, шт.: 30

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Коротко о товаре

Артикул Маркета
3672107119
Тип препарата
Назначение
Действующее вещество
Возраст
от 12 лет
Инструкция
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Таблетки рекомендуется запивать стаканом воды.\u003Cbr\u003EВзрослые\u003Cbr\u003E10 мг (1 таблетка) один раз в сутки.\u003Cbr\u003EОтдельные группы пациентов\u003Cbr\u003EПациенты пожилого возраста\u003Cbr\u003EНет необходимости в снижении дозировки у пациентов пожилого возраста, если функция почек не нарушена.\u003Cbr\u003EПациенты с почечной недостаточностью\u003Cbr\u003EПоскольку цетиризин выводится из организма в основном почками, при невозможности альтернативного лечения пациентам с почечной недостаточностью режим дозирования препарата следует корректировать в зависимости от функции почек (величины клиренса креатинина КК).\u003Cbr\u003EКлиренс креатинина (КК) для мужчин можно рассчитать, исходя из концентрации сывороточного креатинина, по следующей формуле:\u003Cbr\u003EКК (мл/мин) = [140-возраст (годы)] х масса тела (кг) / 72хКК сыворот (мг/дл)\u003Cbr\u003EКК для женщин можно рассчитать, умножив полученное значение на коэффициент 0,85.\u003Cbr\u003EПациенты с нарушением функции печени\u003Cbr\u003EУ пациентов с нарушением только функции печени коррекции режима дозирования не требуется.\u003Cbr\u003EУ пациентов с нарушением и функции печени, и функции почек рекомендуется коррекция дозирования (см. таблицу выше).\u003Cbr\u003EДети\u003Cbr\u003EДети старше 12 лет 10 мг (1 таблетка) один раз в сутки.\u003Cbr\u003EДетям с почечной недостаточностью дозу корректируют с учетом КК и массы тела."},{"name":"Побочные действия","value":"Данные, полученные в клинических исследованиях:\u003Cbr\u003EОбзор\u003Cbr\u003EРезультаты клинических исследований продемонстрировали, что применение цетиризина в рекомендованных дозах приводит к развитию незначительных нежелательных эффектов на ЦНС, включая сонливость, утомляемость, головокружение и головную боль. В некоторых случаях была зарегистрирована парадоксальная стимуляция ЦНС.\u003Cbr\u003EНесмотря на то, что цетиризин является селективным блокатором периферических H1- рецепторов и практически не оказывает антихолинергического действия, сообщалось о единичных случаях затруднения мочеиспускания, нарушениях аккомодации и сухости во рту.\u003Cbr\u003EСообщалось о нарушениях функции печени, сопровождающихся повышением уровня печеночных ферментов и билирубина. В большинстве случаев нежелательные явления разрешались после прекращения приема цетиризина дигидрохлорида.\u003Cbr\u003EПеречень нежелательных побочных реакций\u003Cbr\u003EИмеются данные, полученные в ходе двойных слепых контролируемых клинических исследований, направленных на сравнение цетиризина и плацебо или других антигистаминных препаратов, применяемых в рекомендованных дозах (10 мг один раз в сутки для цетиризина) более чем у 3200 пациентов, на основании которых можно провести достоверный анализ данных по безопасности.\u003Cbr\u003EХотя частота случаев сонливости в группе цетиризина была выше, чем таковая в группе плацебо, в большинстве случаев это нежелательное явление было легкой или умеренной степени тяжести. При объективной оценке, проводимой в рамках других исследований, было подтверждено, что применение цетиризина в рекомендованной суточной дозе у здоровых молодых добровольцев не влияет на их повседневную активность.\u003Cbr\u003EОпыт пострегистрационного применения\u003Cbr\u003EПомимо нежелательных явлений, выявленных в ходе клинических исследований и описанных выше, в рамках пострегистрационного применения препарата наблюдались следующие нежелательные реакции.\u003Cbr\u003EНежелательные явления представлены ниже по классам системы органов MedDRA и частоте развития, на основании данных пострегистрационного применения препарата.\u003Cbr\u003EКлассификация побочных реакций по органам и системам с указанием частоты их возникновения: очень часто (≥ 1/10), часто (≥ 1/100, \u003C 1/10), нечасто (≥ 1/1000, \u003C 1/100), редко (≥ 1/10000, \u003C 1/1000), очень редко (\u003C 1/10000), в том числе отдельные сообщения, частота неизвестна (из-за недостаточности данных).\u003Cbr\u003EНарушения со стороны крови и лимфатической систем:.\u003Cbr\u003Eочень редко - тромбоцитопения.\u003Cbr\u003EНарушения со стороны иммунной системы:\u003Cbr\u003Eредко - реакции гиперчувствительности;\u003Cbr\u003Eочень редко - анафилактический шок.\u003Cbr\u003EНарушения со стороны обмена веществ и питания:\u003Cbr\u003Eчастота неизвестна - повышение аппетита.\u003Cbr\u003EНарушения психики:\u003Cbr\u003Eнечасто - возбуждение;\u003Cbr\u003Eредко - агрессия, спутанность сознания, депрессия, галлюцинации, нарушение сна; очень редко - тик;\u003Cbr\u003Eчастота неизвестна - суицидальные идеи, нарушения сна (включая кошмарные сновидения).\u003Cbr\u003EНарушения со стороны нервной системы:\u003Cbr\u003Eнечасто - парестезии;\u003Cbr\u003Eредко - судороги;\u003Cbr\u003Eочень редко - извращение вкуса, дискинезия, дистония, обморок, тремор;\u003Cbr\u003Eчастота неизвестна - нарушение памяти, в том числе амнезия, глухота.\u003Cbr\u003EНарушения со стороны органа зрения:\u003Cbr\u003Eочень редко - нарушение аккомодации, нечеткость зрения, нистагм;\u003Cbr\u003Eчастота неизвестна - васкулит.\u003Cbr\u003EНарушения со стороны органов слуха и лабиринтные нарушения:\u003Cbr\u003Eчастота неизвестна - вертиго.\u003Cbr\u003EНарушения со стороны сердца:\u003Cbr\u003Eредко - тахикардия.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта:\u003Cbr\u003Eнечасто - диарея.\u003Cbr\u003EНарушения со стороны печени и желчевыводящих протоков:\u003Cbr\u003Eредко - печеночная недостаточность с изменением функциональных печеночных проб (повышение активности трансаминаз, щелочной фосфатазы, гамма-глутамилтрансферазы и билирубина).\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей:\u003Cbr\u003Eнечасто - сыпь, зуд;\u003Cbr\u003Eредко - крапивница;\u003Cbr\u003Eочень редко - ангионевротический отек, стойкая лекарственная эритема.\u003Cbr\u003EНарушения со стороны скелетно-мышечной системы и соединительной ткани:\u003Cbr\u003Eчастота неизвестна - артралгия.\u003Cbr\u003EНарушения со стороны почек и мочевыводящих путей:\u003Cbr\u003Eочень редко - дизурия, энурез;\u003Cbr\u003Eчастота неизвестна - задержка мочи.\u003Cbr\u003EОбщие расстройства и нарушения в месте введения:\u003Cbr\u003Eнечасто - астения, недомогание;\u003Cbr\u003Eредко - периферические отеки.\u003Cbr\u003EВлияние на результаты лабораторных и инструментальных исследований:\u003Cbr\u003Eредко - повышение массы тела.\u003Cbr\u003EОписание отдельных нежелательных реакций\u003Cbr\u003EПосле прекращения применения цетиризина были отмечены случаи зуда (в том числе интенсивного зуда) и/или крапивницы.\u003Cbr\u003EОповещение о побочных реакциях\u003Cbr\u003EБольшое значение имеет система оповещения о подозреваемых побочных реакциях после регистрации лекарственного препарата.\u003Cbr\u003EЭто позволяет вести непрерывный мониторинг соотношения польза/риск лекарственного препарата."},{"name":"Фармакологическое действие","value":"Фармакодинамические свойства\u003Cbr\u003EМеханизм действия\u003Cbr\u003EЦетиризин - активное вещество препарата - является метаболитом гидроксизина, обладает антигистаминным эффектом с противоаллергическим действием. Цетиризин относится к группе конкурентных антагонистов гистамина и блокирует Н1-гистаминовые рецепторы с небольшим воздействием на другие рецепторы и практически не оказывает антихолинергического и антисеротонинового действия.\u003Cbr\u003EЦетиризин оказывает влияние на гистамии-зависимую стадию аллергических реакций немедленного действия, а также уменьшает миграцию эозинофилов и ограничивает высвобождение медиаторов при аллергических реакциях замедленного типа. Практически не проходит через гематоэнцефаличский барьер и, следовательно, почти не способен достичь центральных рецепторов H1.\u003Cbr\u003EФармакодинамика\u003Cbr\u003EВ исследованиях влияния гистамина на кожу действие цетиризина в дозе 10 мг начиналось через 1 час, достигало максимума со 2-го по 12-ый час и все еще наблюдалось на статистически значимых уровнях через 24 часа. В дополнении к антигистаминному эффекту цетиризин также обладает противовоспалительным эффектом и тем самым оказывает влияние на позднюю фазу аллергической реакции:\u003Cbr\u003E- При дозе 10 мг один или два раза в день, ингибирует позднюю фазу агрегации эозинофилов в коже;\u003Cbr\u003E- При дозе 30 мг в день, ингибирует выведение эозинофилов в бронхиальную альвеолярную жидкость после вызванного аллергеном бронхиального сужения;\u003Cbr\u003E- Ингибирует вызванную калликреином позднюю воспалительную реакцию;\u003Cbr\u003E- Подавляет экспрессию маркеров воспаления, таких как ICAM-1 или VCAM-1;\u003Cbr\u003E- Ингибирует действие гистаминолибераторов, таких как PAF или субстанция Р."},{"name":"Фармакологическая группа","value":"H1-гистаминовых рецепторов блокатор"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-allergii","categoryId":"15756502","navnodeId":"72464","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 12 лет"},{"name":"Условия хранения","value":"Хранить в защищенном от света месте при температуре не выше 25 °C.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы\u003Cbr\u003EПри однократном приеме препарата в дозе 50 мг наблюдались следующие симптомы: спутанность сознания, диарея, головокружение, повышенная утомляемость, головная боль, недомогание, мидриаз, зуд, беспокойство, слабость, седативный эффект, сонливость, ступор, тахикардия, тремор, задержка мочи.\u003Cbr\u003EЛечение\u003Cbr\u003EСразу после приема препарата - промывание желудка или стимуляция рвоты. Рекомендуется прием активированного угля, проведение симптоматической и поддерживающей терапии. Специфического антидота нет.\u003Cbr\u003EГемодиализ неэффективен."},{"name":"Применение при беременности и кормлении грудью","value":"Беременность\u003Cbr\u003EПри анализе проспективных данных более чем 700 случаев исходов беременности не выявлено случаев формирования пороков развития, эмбриональной или неонатальной токсичности с четкой причинно-следственной связью.\u003Cbr\u003EЭкспериментальные исследования на животных не выявили каких-либо прямых или косвенных неблагоприятных эффектов цетиризина на развивающийся плод (в том числе в постнатальном периоде), течение беременности и родов.\u003Cbr\u003EАдекватных и строго контролируемых клинических исследований по безопасности применения препарата во время беременности не проводилось, поэтому препарат не следует применять при беременности.\u003Cbr\u003EПериод грудного вскармливания\u003Cbr\u003EЦетиризин выделяется с грудным молоком в концентрации, представляющей от 25 % до 90 % от концентрации препарата в плазме крови в зависимости от времени после назначения. В период грудного вскармливания применяют после консультации с врачом, если предполагаемая польза для матери превышает потенциальный риск для ребенка.\u003Cbr\u003EФертильность\u003Cbr\u003EДоступные данные о влиянии на фертильность человека ограничены, однако отрицательного влияния на фертильность не выявлено."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"При объективной оценке способности к управлению транспортными средствами и механизмами достоверно не было выявлено каких-либо нежелательных явлений при приеме препарата в рекомендуемой дозе. Однако пациентам с проявлениями сонливости на фоне приема препарата следует воздерживаться от управления транспортными средствами и механизмами, занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"Рекомендовано соблюдать осторожность при применении цетиризина одновременно с алкоголем.\u003Cbr\u003EУ пациентов с повреждением спинного мозга, гиперплазией предстательной железы, а также при наличии других предрасполагающих факторов к задержке мочи, требуется соблюдение осторожности, так как цетиризин может увеличивать риск задержки мочи.\u003Cbr\u003EОсторожность следует соблюдать у пациентов с эпилепсией и повышенной судорожной готовностью.\u003Cbr\u003EПеред назначением аллергологических проб рекомендован трехдневный \"отмывочный\" период ввиду того, что блокаторы Hi-гистаминовых рецепторов ингибируют развитие кожных аллергических реакций.\u003Cbr\u003EЦетиризин в таблетках, покрытых пленочной оболочкой, не должен назначаться пациентам с наследственной непереносимостью лактозы, дефицитом лактазы или с синдромом глюкозо-галактозной мальабсорбции.\u003Cbr\u003EПосле прекращения применения цетиризина может появиться зуд и/или крапивница, даже если эти симптомы отсутствовали в начале лечения. В некоторых случаях симптомы могут быть интенсивными и требовать возобновления приема цетиризина. Симптомы исчезают при возобновлении приема цетиризина.\u003Cbr\u003EС осторожностью:\u003Cbr\u003E- Пациенты пожилого возраста (при возрастном снижении клубочковой фильтрации);\u003Cbr\u003E- эпилепсия и пациенты с повышенной судорожной готовностью;\u003Cbr\u003E- пациенты с предрасполагающими факторами к задержке мочи;\u003Cbr\u003E- период грудного вскармливания."},{"name":"Взаимодействие","value":"На основании анализа фармакодинамики, фармакокинетики цетиризина взаимодействие с другими лекарственными препаратами маловероятно.\u003Cbr\u003EНе было отмечено значимых взаимодействий с псевдоэфедрином и теофиллином (в дозе 400 мг в сутки) в специальных исследованиях лекарственного взаимодействия.\u003Cbr\u003EОдновременное применение цетиризина с алкоголем и другими препаратами, угнетающими ЦНС, может способствовать дальнейшему снижению концентрации внимания и быстроты реакций, хотя цетиризин не усиливает эффект алкоголя (при его концентрации в крови 0,5 г/л)."},{"name":"Регистрационный номер","value":"ЛП-000381"},{"name":"Дата государственной регистрации","value":"11.11.2019"},{"name":"Владелец регистрационного удостоверения","value":"Вертекс","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-allergii","categoryId":"15756502","navnodeId":"72464","glfilters":["34324371:35649313","7893318:8514228"]}}},{"name":"Изготовитель","value":"Вертекс"},{"name":"Фасовщик","value":"Вертекс"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Цетиризин","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-allergii","categoryId":"15756502","navnodeId":"72464","glfilters":["17796364:17878930"]}}},{"name":"Срок годности","value":"36 мес."}]}},"fullSpecsGrouped":{"6962038607294542924":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Органы и системы","value":"глаза, кожа, носовая полость"},{"name":"Назначение","value":"аллергический конъюнктивит, аллергический ринит, зуд, крапивница, слезотечение, чихание"},{"name":"Показания к применению","value":"- Облегчение назальных и глазных симптомов круглогодичного (персистирующего) и сезонного (интермиттирующего) аллергического ринита и аллергического конъюнктивита, таких как зуд, чихание, заложенность носа, ринорея, слезотечение, гиперемия конъюнктивы;\u003Cbr\u003E- облегчение симптомов хронической идиопатической крапивницы."},{"name":"Противопоказания","value":"- Повышенная чувствительность к цетиризину, гидроксизину или производным пиперазина, а также другим компонентам препарата;\u003Cbr\u003E- почечная недостаточность (клиренс креатинина \u003C 50 мл/мин) (для данной лекарственной формы);\u003Cbr\u003E- дефицит лактазы, непереносимость лактозы, глюкозо-галактозная мальабсорбция;\u003Cbr\u003E- детский возраст до 12 лет (для данной лекарственной формы);\u003Cbr\u003E- беременность."},{"name":"Состав","value":"Одна таблетка содержит:\u003Cbr\u003Eдействующее вещество: цетиризина дигидрохлорид - 10,0 мг;\u003Cbr\u003Eвспомогательные вещества: лактозы моногидрат - 70,0 мг; целлюлоза микрокристаллическая - 34,0 мг; кросповидон - 3,6 мг; магния стеарат - 1,2 мг; кремния диоксид коллоидный - 1,2 мг;\u003Cbr\u003Eпленочная оболочка: [гипромеллоза - 2,40 мг, тальк - 0,80 мг, титана диоксид - 0,44 мг, макрогол 4000 (полиэтиленгликоль 4000) - 0,36 мг] или [сухая смесь для пленочного покрытия, содержащая гипромеллозу (60 %), тальк (20 %), титана диоксид (11 %), макрогол 4000 (полиэтиленгликоль 4000) (9 %)] - 4,0 мг."},{"name":"Действующее вещество","value":"Цетиризин"},{"name":"Способ применения и дозы","value":"Внутрь. Таблетки рекомендуется запивать стаканом воды.\u003Cbr\u003EВзрослые\u003Cbr\u003E10 мг (1 таблетка) один раз в сутки.\u003Cbr\u003EОтдельные группы пациентов\u003Cbr\u003EПациенты пожилого возраста\u003Cbr\u003EНет необходимости в снижении дозировки у пациентов пожилого возраста, если функция почек не нарушена.\u003Cbr\u003EПациенты с почечной недостаточностью\u003Cbr\u003EПоскольку цетиризин выводится из организма в основном почками, при невозможности альтернативного лечения пациентам с почечной недостаточностью режим дозирования препарата следует корректировать в зависимости от функции почек (величины клиренса креатинина КК).\u003Cbr\u003EКлиренс креатинина (КК) для мужчин можно рассчитать, исходя из концентрации сывороточного креатинина, по следующей формуле:\u003Cbr\u003EКК (мл/мин) = [140-возраст (годы)] х масса тела (кг) / 72хКК сыворот (мг/дл)\u003Cbr\u003EКК для женщин можно рассчитать, умножив полученное значение на коэффициент 0,85.\u003Cbr\u003EПациенты с нарушением функции печени\u003Cbr\u003EУ пациентов с нарушением только функции печени коррекции режима дозирования не требуется.\u003Cbr\u003EУ пациентов с нарушением и функции печени, и функции почек рекомендуется коррекция дозирования (см. таблицу выше).\u003Cbr\u003EДети\u003Cbr\u003EДети старше 12 лет 10 мг (1 таблетка) один раз в сутки.\u003Cbr\u003EДетям с почечной недостаточностью дозу корректируют с учетом КК и массы тела."},{"name":"Побочные действия","value":"Данные, полученные в клинических исследованиях:\u003Cbr\u003EОбзор\u003Cbr\u003EРезультаты клинических исследований продемонстрировали, что применение цетиризина в рекомендованных дозах приводит к развитию незначительных нежелательных эффектов на ЦНС, включая сонливость, утомляемость, головокружение и головную боль. В некоторых случаях была зарегистрирована парадоксальная стимуляция ЦНС.\u003Cbr\u003EНесмотря на то, что цетиризин является селективным блокатором периферических H1- рецепторов и практически не оказывает антихолинергического действия, сообщалось о единичных случаях затруднения мочеиспускания, нарушениях аккомодации и сухости во рту.\u003Cbr\u003EСообщалось о нарушениях функции печени, сопровождающихся повышением уровня печеночных ферментов и билирубина. В большинстве случаев нежелательные явления разрешались после прекращения приема цетиризина дигидрохлорида.\u003Cbr\u003EПеречень нежелательных побочных реакций\u003Cbr\u003EИмеются данные, полученные в ходе двойных слепых контролируемых клинических исследований, направленных на сравнение цетиризина и плацебо или других антигистаминных препаратов, применяемых в рекомендованных дозах (10 мг один раз в сутки для цетиризина) более чем у 3200 пациентов, на основании которых можно провести достоверный анализ данных по безопасности.\u003Cbr\u003EХотя частота случаев сонливости в группе цетиризина была выше, чем таковая в группе плацебо, в большинстве случаев это нежелательное явление было легкой или умеренной степени тяжести. При объективной оценке, проводимой в рамках других исследований, было подтверждено, что применение цетиризина в рекомендованной суточной дозе у здоровых молодых добровольцев не влияет на их повседневную активность.\u003Cbr\u003EОпыт пострегистрационного применения\u003Cbr\u003EПомимо нежелательных явлений, выявленных в ходе клинических исследований и описанных выше, в рамках пострегистрационного применения препарата наблюдались следующие нежелательные реакции.\u003Cbr\u003EНежелательные явления представлены ниже по классам системы органов MedDRA и частоте развития, на основании данных пострегистрационного применения препарата.\u003Cbr\u003EКлассификация побочных реакций по органам и системам с указанием частоты их возникновения: очень часто (≥ 1/10), часто (≥ 1/100, \u003C 1/10), нечасто (≥ 1/1000, \u003C 1/100), редко (≥ 1/10000, \u003C 1/1000), очень редко (\u003C 1/10000), в том числе отдельные сообщения, частота неизвестна (из-за недостаточности данных).\u003Cbr\u003EНарушения со стороны крови и лимфатической систем:.\u003Cbr\u003Eочень редко - тромбоцитопения.\u003Cbr\u003EНарушения со стороны иммунной системы:\u003Cbr\u003Eредко - реакции гиперчувствительности;\u003Cbr\u003Eочень редко - анафилактический шок.\u003Cbr\u003EНарушения со стороны обмена веществ и питания:\u003Cbr\u003Eчастота неизвестна - повышение аппетита.\u003Cbr\u003EНарушения психики:\u003Cbr\u003Eнечасто - возбуждение;\u003Cbr\u003Eредко - агрессия, спутанность сознания, депрессия, галлюцинации, нарушение сна; очень редко - тик;\u003Cbr\u003Eчастота неизвестна - суицидальные идеи, нарушения сна (включая кошмарные сновидения).\u003Cbr\u003EНарушения со стороны нервной системы:\u003Cbr\u003Eнечасто - парестезии;\u003Cbr\u003Eредко - судороги;\u003Cbr\u003Eочень редко - извращение вкуса, дискинезия, дистония, обморок, тремор;\u003Cbr\u003Eчастота неизвестна - нарушение памяти, в том числе амнезия, глухота.\u003Cbr\u003EНарушения со стороны органа зрения:\u003Cbr\u003Eочень редко - нарушение аккомодации, нечеткость зрения, нистагм;\u003Cbr\u003Eчастота неизвестна - васкулит.\u003Cbr\u003EНарушения со стороны органов слуха и лабиринтные нарушения:\u003Cbr\u003Eчастота неизвестна - вертиго.\u003Cbr\u003EНарушения со стороны сердца:\u003Cbr\u003Eредко - тахикардия.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта:\u003Cbr\u003Eнечасто - диарея.\u003Cbr\u003EНарушения со стороны печени и желчевыводящих протоков:\u003Cbr\u003Eредко - печеночная недостаточность с изменением функциональных печеночных проб (повышение активности трансаминаз, щелочной фосфатазы, гамма-глутамилтрансферазы и билирубина).\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей:\u003Cbr\u003Eнечасто - сыпь, зуд;\u003Cbr\u003Eредко - крапивница;\u003Cbr\u003Eочень редко - ангионевротический отек, стойкая лекарственная эритема.\u003Cbr\u003EНарушения со стороны скелетно-мышечной системы и соединительной ткани:\u003Cbr\u003Eчастота неизвестна - артралгия.\u003Cbr\u003EНарушения со стороны почек и мочевыводящих путей:\u003Cbr\u003Eочень редко - дизурия, энурез;\u003Cbr\u003Eчастота неизвестна - задержка мочи.\u003Cbr\u003EОбщие расстройства и нарушения в месте введения:\u003Cbr\u003Eнечасто - астения, недомогание;\u003Cbr\u003Eредко - периферические отеки.\u003Cbr\u003EВлияние на результаты лабораторных и инструментальных исследований:\u003Cbr\u003Eредко - повышение массы тела.\u003Cbr\u003EОписание отдельных нежелательных реакций\u003Cbr\u003EПосле прекращения применения цетиризина были отмечены случаи зуда (в том числе интенсивного зуда) и/или крапивницы.\u003Cbr\u003EОповещение о побочных реакциях\u003Cbr\u003EБольшое значение имеет система оповещения о подозреваемых побочных реакциях после регистрации лекарственного препарата.\u003Cbr\u003EЭто позволяет вести непрерывный мониторинг соотношения польза/риск лекарственного препарата."},{"name":"Фармакологическое действие","value":"Фармакодинамические свойства\u003Cbr\u003EМеханизм действия\u003Cbr\u003EЦетиризин - активное вещество препарата - является метаболитом гидроксизина, обладает антигистаминным эффектом с противоаллергическим действием. Цетиризин относится к группе конкурентных антагонистов гистамина и блокирует Н1-гистаминовые рецепторы с небольшим воздействием на другие рецепторы и практически не оказывает антихолинергического и антисеротонинового действия.\u003Cbr\u003EЦетиризин оказывает влияние на гистамии-зависимую стадию аллергических реакций немедленного действия, а также уменьшает миграцию эозинофилов и ограничивает высвобождение медиаторов при аллергических реакциях замедленного типа. Практически не проходит через гематоэнцефаличский барьер и, следовательно, почти не способен достичь центральных рецепторов H1.\u003Cbr\u003EФармакодинамика\u003Cbr\u003EВ исследованиях влияния гистамина на кожу действие цетиризина в дозе 10 мг начиналось через 1 час, достигало максимума со 2-го по 12-ый час и все еще наблюдалось на статистически значимых уровнях через 24 часа. В дополнении к антигистаминному эффекту цетиризин также обладает противовоспалительным эффектом и тем самым оказывает влияние на позднюю фазу аллергической реакции:\u003Cbr\u003E- При дозе 10 мг один или два раза в день, ингибирует позднюю фазу агрегации эозинофилов в коже;\u003Cbr\u003E- При дозе 30 мг в день, ингибирует выведение эозинофилов в бронхиальную альвеолярную жидкость после вызванного аллергеном бронхиального сужения;\u003Cbr\u003E- Ингибирует вызванную калликреином позднюю воспалительную реакцию;\u003Cbr\u003E- Подавляет экспрессию маркеров воспаления, таких как ICAM-1 или VCAM-1;\u003Cbr\u003E- Ингибирует действие гистаминолибераторов, таких как PAF или субстанция Р."},{"name":"Фармакологическая группа","value":"H1-гистаминовых рецепторов блокатор"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 12 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Хранить в защищенном от света месте при температуре не выше 25 °C.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы\u003Cbr\u003EПри однократном приеме препарата в дозе 50 мг наблюдались следующие симптомы: спутанность сознания, диарея, головокружение, повышенная утомляемость, головная боль, недомогание, мидриаз, зуд, беспокойство, слабость, седативный эффект, сонливость, ступор, тахикардия, тремор, задержка мочи.\u003Cbr\u003EЛечение\u003Cbr\u003EСразу после приема препарата - промывание желудка или стимуляция рвоты. Рекомендуется прием активированного угля, проведение симптоматической и поддерживающей терапии. Специфического антидота нет.\u003Cbr\u003EГемодиализ неэффективен."},{"name":"Применение при беременности и кормлении грудью","value":"Беременность\u003Cbr\u003EПри анализе проспективных данных более чем 700 случаев исходов беременности не выявлено случаев формирования пороков развития, эмбриональной или неонатальной токсичности с четкой причинно-следственной связью.\u003Cbr\u003EЭкспериментальные исследования на животных не выявили каких-либо прямых или косвенных неблагоприятных эффектов цетиризина на развивающийся плод (в том числе в постнатальном периоде), течение беременности и родов.\u003Cbr\u003EАдекватных и строго контролируемых клинических исследований по безопасности применения препарата во время беременности не проводилось, поэтому препарат не следует применять при беременности.\u003Cbr\u003EПериод грудного вскармливания\u003Cbr\u003EЦетиризин выделяется с грудным молоком в концентрации, представляющей от 25 % до 90 % от концентрации препарата в плазме крови в зависимости от времени после назначения. В период грудного вскармливания применяют после консультации с врачом, если предполагаемая польза для матери превышает потенциальный риск для ребенка.\u003Cbr\u003EФертильность\u003Cbr\u003EДоступные данные о влиянии на фертильность человека ограничены, однако отрицательного влияния на фертильность не выявлено."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"При объективной оценке способности к управлению транспортными средствами и механизмами достоверно не было выявлено каких-либо нежелательных явлений при приеме препарата в рекомендуемой дозе. Однако пациентам с проявлениями сонливости на фоне приема препарата следует воздерживаться от управления транспортными средствами и механизмами, занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"Рекомендовано соблюдать осторожность при применении цетиризина одновременно с алкоголем.\u003Cbr\u003EУ пациентов с повреждением спинного мозга, гиперплазией предстательной железы, а также при наличии других предрасполагающих факторов к задержке мочи, требуется соблюдение осторожности, так как цетиризин может увеличивать риск задержки мочи.\u003Cbr\u003EОсторожность следует соблюдать у пациентов с эпилепсией и повышенной судорожной готовностью.\u003Cbr\u003EПеред назначением аллергологических проб рекомендован трехдневный \"отмывочный\" период ввиду того, что блокаторы Hi-гистаминовых рецепторов ингибируют развитие кожных аллергических реакций.\u003Cbr\u003EЦетиризин в таблетках, покрытых пленочной оболочкой, не должен назначаться пациентам с наследственной непереносимостью лактозы, дефицитом лактазы или с синдромом глюкозо-галактозной мальабсорбции.\u003Cbr\u003EПосле прекращения применения цетиризина может появиться зуд и/или крапивница, даже если эти симптомы отсутствовали в начале лечения. В некоторых случаях симптомы могут быть интенсивными и требовать возобновления приема цетиризина. Симптомы исчезают при возобновлении приема цетиризина.\u003Cbr\u003EС осторожностью:\u003Cbr\u003E- Пациенты пожилого возраста (при возрастном снижении клубочковой фильтрации);\u003Cbr\u003E- эпилепсия и пациенты с повышенной судорожной готовностью;\u003Cbr\u003E- пациенты с предрасполагающими факторами к задержке мочи;\u003Cbr\u003E- период грудного вскармливания."},{"name":"Взаимодействие","value":"На основании анализа фармакодинамики, фармакокинетики цетиризина взаимодействие с другими лекарственными препаратами маловероятно.\u003Cbr\u003EНе было отмечено значимых взаимодействий с псевдоэфедрином и теофиллином (в дозе 400 мг в сутки) в специальных исследованиях лекарственного взаимодействия.\u003Cbr\u003EОдновременное применение цетиризина с алкоголем и другими препаратами, угнетающими ЦНС, может способствовать дальнейшему снижению концентрации внимания и быстроты реакций, хотя цетиризин не усиливает эффект алкоголя (при его концентрации в крови 0,5 г/л)."},{"name":"Регистрационный номер","value":"ЛП-000381"},{"name":"Дата государственной регистрации","value":"11.11.2019"},{"name":"Владелец регистрационного удостоверения","value":"Вертекс"},{"name":"Изготовитель","value":"Вертекс"},{"name":"Фасовщик","value":"Вертекс"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Цетиризин"},{"name":"Срок годности","value":"36 мес."}]}],"transitionId":"tr_7494290695613177330"}}}}
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Цена с картой Яндекс Пэй:133 ₽

Скидка: 16%
–16 %
Вместо: 134 ₽158 ₽
  • Сегодня, курьер магазина • 249 ₽
  • Сегодня, самовывоз • 0 ₽
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    С картой  Пэй
    Цена с картой Яндекс Пэй 304 ₽ вместо 307
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  • Аллервэй таб. п/о плен., 5мг, 30 шт.
    –1 %
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    Аллервэй таб. п/о плен., 5мг, 30 шт.

    Рейтинг товара: 4.9 из 5
    на основе 60 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 594 ₽ вместо 600
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таб. п/о плен., 5мг, 30 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  • Цетиризин таб. п/о. плен., 10 мг, 20 шт.
    –1 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-wsgzck414zr/toggleWishlist":{"skuId":"186887934","productId":1780856570,"offerId":"PdsbE_3gVCoIRGJWl-beNg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQsoyeisLGk+gUEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI+u2W0QYQ/t2OWRjfstUHINbZwQc=","sign":"TMI7oWKRZya/TT/kUUkqsNCGe1bW75oRyFmdCmdkQZc="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-wsgzck414zr/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Цетиризин таб. п/о. плен., 10 мг, 20 шт.

    Рейтинг товара: 4.7 из 5
    на основе 33 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 95 ₽ вместо 96
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  • Лоратадин таб., 10 мг, 10 шт.
    –2 %
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    Лоратадин таб., 10 мг, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 7 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 113 ₽ вместо 115
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  • Супрастин таб., 25 мг, 1 мл, 20 шт.
    –1 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-smuhzarhp7q/toggleWishlist":{"skuId":"227814489","productId":1417730446,"offerId":"ttLUz-JKZSjXA_t8MoRN1A","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQsoyeisLGk+gUEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIjrODpAUQ2djQbBiS3dAHINbZwQc=","sign":"ostGhkDByeWpVNh9eH43OFWJTbg9Omx3YrcVKA3+gig="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-smuhzarhp7q/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Супрастин таб., 25 мг, 1 мл, 20 шт.

    Рейтинг товара: 4.8 из 5
    на основе 95 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 130 ₽ вместо 131
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  • Цетиризин таб., 10 мг, 10 шт.
    –14 %
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    Цетиризин таб., 10 мг, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 49 ₽ вместо 57
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  • Цетиризин Реневал таб., 10 мг, 30 шт.
    –1 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-otnnp2ji9dm/toggleWishlist":{"skuId":"101444706111","productId":1436120259,"offerId":"2XzDlkVyGuyLfn3yHjbk0g","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQsoyeisLGk+gUEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIw+nlrAUQv77N9PkCGPKsgggg1tnBBw==","sign":"9XXqF9Z4qQe3//sehPhlT5G1hkf9i4lDHs/iflOuP4I="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-otnnp2ji9dm/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Цетиризин Реневал таб., 10 мг, 30 шт.

    Рейтинг товара: 4.8 из 5
    на основе 24 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 135 ₽ вместо 136
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  • Лоратадин таб., 10 мг, 30 шт.
    –17 %
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    Лоратадин таб., 10 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 61 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 80 ₽ вместо 81
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таб., 10 мг, 30 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  • Цетиризин Сандоз таб. п/о, 10 мг, 10 шт.
    –2 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-mrbjgu0nkee/toggleWishlist":{"skuId":"227830547","productId":1778170118,"offerId":"x9u8-FuzL5qo7gF2Ku8pyQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQsoyeisLGk+gUEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIhvLyzwYQk9bRbBjEnNAHINbZwQc=","sign":"PvMG2suDVWgkOP2Yro7wJV2AQ8ttMOW/cdrxoCJj5Pc="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-mrbjgu0nkee/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Цетиризин Сандоз таб. п/о, 10 мг, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 5 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 58 ₽ вместо 59
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  • Лоратадин таб., 10 мг, 10 шт.
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    Лоратадин таб., 10 мг, 10 шт.

    Рейтинг товара: 4.9 из 5
    на основе 125 оценок
    Цена 26 ₽
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  • Зиртек таб. п/о плен., 10 мг, 30 шт.
    –1 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-2o5d6unsf49/toggleWishlist":{"skuId":"101481348731","productId":787956050,"offerId":"XPLgaqDqev-6Rz6VWFmbtQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQsoyeisLGk+gUEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI0oLd9wIQ+/yJhvoCGLzE3gcg1tnBBw==","sign":"R+8UlhmaFnOdKTa+phcB7dP9k3J0c+febzjvxsIRWiQ="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-2o5d6unsf49/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Зиртек таб. п/о плен., 10 мг, 30 шт.

    Рейтинг товара: 4.7 из 5
    на основе 22 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 291 ₽ вместо 294
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Инструкция

Показания к применению

- Облегчение назальных и глазных симптомов круглогодичного (персистирующего) и сезонного (интермиттирующего) аллергического ринита и аллергического конъюнктивита, таких как зуд, чихание, заложенность носа, ринорея, слезотечение, гиперемия конъюнктивы;
- облегчение симптомов хронической идиопатической крапивницы.

Противопоказания

- Повышенная чувствительность к цетиризину, гидроксизину или производным пиперазина, а также другим компонентам препарата;
- почечная недостаточность (клиренс креатинина < 50 мл/мин) (для данной лекарственной формы);
- дефицит лактазы, непереносимость лактозы, глюкозо-галактозная мальабсорбция;
- детский возраст до 12 лет (для данной лекарственной формы);
- беременность.

Способ применения и дозы

Внутрь. Таблетки рекомендуется запивать стаканом воды.
Взрослые
10 мг (1 таблетка) один раз в сутки.
Отдельные группы пациентов
Пациенты пожилого возраста
Нет необходимости в снижении дозировки у пациентов пожилого возраста, если функция почек не нарушена.
Пациенты с почечной недостаточностью
Поскольку цетиризин выводится из организма в основном почками, при невозможности альтернативного лечения пациентам с почечной недостаточностью режим дозирования препарата следует корректировать в зависимости от функции почек (величины клиренса креатинина КК).
Клиренс креатинина (КК) для мужчин можно рассчитать, исходя из концентрации сывороточного креатинина, по следующей формуле:
КК (мл/мин) = [140-возраст (годы)] х масса тела (кг) / 72хКК сыворот (мг/дл)
КК для женщин можно рассчитать, умножив полученное значение на коэффициент 0,85.
Пациенты с нарушением функции печени
У пациентов с нарушением только функции печени коррекции режима дозирования не требуется.
У пациентов с нарушением и функции печени, и функции почек рекомендуется коррекция дозирования (см. таблицу выше).
Дети
Дети старше 12 лет 10 мг (1 таблетка) один раз в сутки.
Детям с почечной недостаточностью дозу корректируют с учетом КК и массы тела.
Полная инструкция
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Цетиризин таб. п/о плен.
Цетиризин таб. п/о плен., 10 мг, 30 шт.
5.0
(47)
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3 вопроса
Инструкция

Цена с картой Яндекс Пэй:133 ₽

Скидка: 16%
–16 %
Вместо: 134 ₽158 ₽
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5.0
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У продавца:47 оценок·6 отзывов
У всех продавцов:108 оценок·32 отзыва
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user avatar
3 месяца назад • Павел • Куплен на Маркете
Комментарий: Помогают, по вкусу как супрастин, функции что то среднее между супрастином и лоротадином
user avatar
Месяц назад • Елена Д. • Куплен на Маркете
Достоинства: Отличное средство от аллергии
Недостатки: Нет
Комментарий: С поставленной задачей справляется.
user avatar
9 месяцев назад • Вера Покусаева • Куплен на Маркете
Достоинства: Цена
Недостатки: Их нет
Комментарий: Таблетки от аллергии. Помогают так же, как и дорогой Цетрин. Так что соотношение цена - качество отличное.
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