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Леветирацетам Канон таб. п/о плен., 500 мг, 60 шт.

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4.9
(17)
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Количество штук в упаковке, шт.: 60

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Коротко о товаре

Артикул Маркета
3310885348
Тип препарата
Назначение
Действующее вещество
Возраст
от 6 лет
Инструкция
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чувствительность к леветирацетаму или другим производным пирролидона, а также к любым компонентам препарата;\u003Cbr\u003E- детский возраст до 6 лет (в данной лекарственной форме при лечении парциальных припадков с вторичной генерализацией или без таковой у детей, страдающих эпилепсией);\u003Cbr\u003E- детский возраст до 12 лет (при лечении миоклонических судорог у детей, страдающих ювенильной миоклонической эпилепсией, и при первично-генерализованных судорожных (тонико-клонических) припадках у детей, страдающих идиопатической генерализованной эпилепсией);\u003Cbr\u003E- масса тела менее 20 кг;\u003Cbr\u003E- детский возраст до 16 лет при лечении парциальных припадков с вторичной генерализацией или без таковой с вновь диагностированной эпилепсией;\u003Cbr\u003E- период грудного вскармливания.\u003Cbr\u003EС осторожностью:\u003Cbr\u003E- Пациенты пожилого возраста (старше 65 лет);\u003Cbr\u003E- заболевания печени в стадии декомпенсации;\u003Cbr\u003E- почечная недостаточность (клиренс креатинина менее 50 мл/мин);\u003Cbr\u003E- депрессия, суицидальное поведение;\u003Cbr\u003E- одновременное применение с сульфаниламидами, пробенецидом, нестероидными противовоспалительными средствами, метотрексатом."},{"name":"Состав","value":"1 таблетка, покрытая пленочной оболочкой, содержит: активное вещество: леветирацетам 500 мг; вспомогательные вещества: кремния диоксид коллоидный 6 мг, кроскармеллоза натрия 20 мг, кальция стеарат 6 мг, маннитол 40,4 мг, повидон 12,6 мг, целлюлоза микрокристаллическая 35 мг; состав пленочной оболочки: Опадрай II синий 20 мг, в том числе: поливиниловый спирт 8 мг, макрогол (полиэтиленгликоль) 4,04 мг, тальк 2,96 мг, титана диоксид 4,1 мг, алюминиевый лак на основе красителя индигокармин 0,86 мг, алюминиевый лак на основе красителя красный очаровательный 0,04 мг."},{"name":"Действующее вещество","value":"Леветирацетам","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["27144131:28709233"]}}},{"name":"Способ применения и дозы","value":"Внутрь, независимо от приема пищи, запивая достаточным количеством жидкости. Суточную дозу препарата делят на два приема в одинаковой дозе.\u003Cbr\u003EМонотерапия\u003Cbr\u003EВзрослым и подросткам старше 16 лет лечение следует начинать с суточной дозы 500 мг, разделенной на 2 приема (по 250 мг 2 раза в сутки). Через 2 недели доза может быть увеличена до начальной терапевтической - 1000 мг (по 500 мг 2 раза в сутки). Максимальная суточная доза составляет 3000 мг (по 1500 мг 2 раза в сутки).\u003Cbr\u003EВ составе комплексной терапии\u003Cbr\u003EДетям старше 6 лет лечение следует начинать с суточной дозы 20 мг/кг массы тела, разделенной на 2 приема (по 10 мг/кг массы тела 2 раза в сутки). Изменение дозы на 20 мг/кг массы тела может осуществляться каждые 2 недели до достижения рекомендуемой суточной дозы - 60 мг/кг массы тела (по 30 мг/кг массы тела 2 раза в сутки). При непереносимости рекомендуемой суточной дозы возможно ее снижение. Следует применять минимальную эффективную дозы. Врач должен назначить препарат в наиболее подходящей дозировке в зависимости от массы тела пациента и необходимой терапевтической дозы.\u003Cbr\u003EДетям с массой тела более 50 кг дозирование осуществляется по схеме, приведенной для взрослых.\u003Cbr\u003EВзрослым и подросткам старше 16 лет с массой тела более 50 кг лечение следует начинать с суточной дозы 1000 мг, разделенной на 2 приема (по 500 мг 2 раза в сутки). В зависимости от клинической реакции и переносимости препарата суточная доза может быть увеличена до максимальной - 3000 мг (по 1500 мг 2 раза в сутки). Изменение дозы на 500 мг 2 раза в сутки может осуществляться каждые 2-4 недели.\u003Cbr\u003EПоскольку леветирацетам выводится из организма почками, при назначении препарата пациентам с почечной недостаточностью и пациентам пожилого возраста дозу следует корректировать в зависимости от величины клиренса креатинина (КК).\u003Cbr\u003EКлиренс креатинина для мужчин можно рассчитать исходя из концентрации сывороточного креатинина по следующей формуле:\u003Cbr\u003EКК (мл/мин)= (140 - возраст (годы)) х масса тела (кг)/ 72 x ККсыворот (мг/дл)\u003Cbr\u003EКлиренс креатинина для женщин можно рассчитать умножив полученное значение на коэффициент 0,85."},{"name":"Побочные действия","value":"Классификация ВОЗ частоты развития побочных эффектов:\u003Cbr\u003Eочень часто - ≥1/10 назначений (\u003E10%)\u003Cbr\u003Eчасто - от ≥1/100 до \u003C 1/10 назначений (\u003E1% и \u003C10%)\u003Cbr\u003Eнечасто - от ≥1/1000 до \u003C1/100 назначений (\u003E0,1% и \u003C1%)\u003Cbr\u003Eредко - от ≥1/10000 до \u003C1/1000 назначений (\u003E0,01% и \u003C0,1%)\u003Cbr\u003Eочень редко - \u003C1/10000 назначений (\u003C0,01%)\u003Cbr\u003EСо стороны нервной системы и психики\u003Cbr\u003EОчень часто: сонливость, головная боль, астенический синдром.\u003Cbr\u003EЧасто: судороги, головокружение, головная боль, тремор, нарушение равновесия, возбуждение, депрессия, переменчивость настроения, враждебность/агрессивность, бессонница, нервозность, раздражительность, расстройства личности, нарушение мышления, тревога, вертиго.\u003Cbr\u003EНечасто: атаксия, амнезия, снижение концентрации внимания, ухудшение памяти, попытки суицида, суицидальные намерения, психотические расстройства, поведенческие расстройства, галлюцинации, спутанность сознания, эмоциональная лабильность.\u003Cbr\u003EРедко: хореоатетоз, дискинезия, гиперкинезия, суицид, расстройство личности, нарушение мышления.\u003Cbr\u003EСо стороны органов зрения\u003Cbr\u003EНечасто: диплопия, нарушение аккомодации.\u003Cbr\u003EСо стороны дыхательной системы\u003Cbr\u003EЧасто: усиление кашля.\u003Cbr\u003EСо стороны пищеварительной системы\u003Cbr\u003EЧасто: абдоминальная боль, диарея, диспепсия, тошнота, рвота, анорексия, повышение массы тела.\u003Cbr\u003EНечасто: панкреатит, изменения функциональных печеночных проб.\u003Cbr\u003EРедко: печеночная недостаточность, гепатит, снижение массы тела.\u003Cbr\u003EСо стороны кожных покровов\u003Cbr\u003EЧасто: кожная сыпь.\u003Cbr\u003EНечасто: экзема, зуд, алопеция (в ряде случаев восстановление волосяного покрова наблюдалось после отмены препарата).\u003Cbr\u003EРедко: токсический эпидермальный некролиз, Синдром Стивенса-Джонсона, многоформная эритема.\u003Cbr\u003EИзменения лабораторных показателей\u003Cbr\u003EНечасто: тромбоцитопения, лейкопения.\u003Cbr\u003EРедко: нейтропения, панцитопения (в некоторых случаях с угнетением функции костного мозга).\u003Cbr\u003EПрочие\u003Cbr\u003EИнфекции, назофарингит, миалгия, мышечная слабость, склонность к травмам.\u003Cbr\u003EУ детей: рвота, возбуждение, переменчивость настроения, эмоциональная лабильность, агрессивность, поведенческие расстройства, летаргия."},{"name":"Фармакологическое действие","value":"Леветирацетам является производным пирролидона (S-энантиомер α-этил-2-оксо-1-пирролидин-ацетамида), по химической структуре отличается от известных противоэпилептических лекарственных средств. Механизм действия леветирацетама до конца не изучен, но очевидно, что он отличается от механизма действия известных противоэпилептических препаратов. Эксперименты in vitro и in vivo показали, что леветирацетам не влияет на основные характеристики клеток и нормальную трансмиссию. В исследованиях in vitro показано, что он влияет на внутринейрональную концентрацию ионов Са, частично тормозя ток ионов кальция через каналы N-типа и уменьшая высвобождение кальция из внутринейрональных депо. Кроме того он частично восстанавливает токи через ГАМК и глицин-зависимые каналы. Один из предполагаемых механизмов основан на доказанном связывании с гликопротеином синаптических везикул SV2A, содержащемся в сером веществе головного и спинного мозга. Считается, что таким образом реализуется противосудорожный эффект, который выражен в противодействии гиперсинхронизации нейронной активности. Также леветирацетам воздействует на рецепторы ГАМК и глициновые рецепторы, модулируя данные рецепторы через различные эндогенные агенты. Препарат не изменяет нормальную нейротрансмиссию, однако подавляет эпилептиформные нейрональные вспышки, индуцированные ГАМК-агонистом бикукулином, и возбуждение глутаматных рецепторов. Активность препарата подтверждена в отношении как фокальных, так и генерализованных эпилептических припадков (эпилептиформные проявления/фотопароксизмальная реакция)."},{"name":"Фармакологическая группа","value":"противоэпилептические средства"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 6 лет"},{"name":"Условия хранения","value":"В сухом, защищенном от света месте, при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы: сонливость, ажитация, агрессивность, угнетение сознания, угнетение дыхания, кома.\u003Cbr\u003EЛечение: в остром периоде - искусственный вызов рвоты и промывание желудка с последующим назначением активированного угля. Специфического антидота для леветирацетама нет. При необходимости проводится симптоматическое лечение в условиях стационара с использованием гемодиализа (эффективность диализа для леветирацетама составляет 60%, для его первичного метаболита - 74%)."},{"name":"Применение при беременности и кормлении грудью","value":"Адекватных и строго контролируемых клинических исследований по безопасности применения леветирацетама у беременных не проводилось, поэтому препарат не следует назначать во время беременности, за исключением случаев крайней необходимости. Необходимо соблюдать контрацепцию женщинам с сохраненным детородным потенциалом.\u003Cbr\u003EФизиологические изменения в организме женщины во время беременности могут влиять на концентрацию в плазме леветирацетама, так же, как и других противоэпилептических препаратов. Во время беременности отмечено снижение концентрации леветирацетама в плазме. Это снижение более выражено в третьем триместре (до 60% от базовой концентрации в период, предшествующий беременности).\u003Cbr\u003EЛечение леветирацетамом беременных следует проводить под особым контролем. Перерывы в проведении противоэпилептической терапии могут привести к ухудшению течения заболевания, что может нанести вред здоровью как матери, так и плода. Леветирацетам выделяется с грудным молоком, поэтому грудное вскармливание при лечении препаратом противопоказано."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Влияние препарата леветирацетама на способность к вождению автотранспорта и управлению механизмами специально не изучалось. Тем не менее, в силу различной индивидуальной чувствительности к препарату со стороны центральной нервной системы в период лечения, необходимо воздерживаться от вождения автотранспорта и занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"Если требуется прекратить прием препарата, то отмену лечения рекомендуется осуществлять постепенно (уменьшая разовую дозу на 500 мг каждые 2-4 недели). У детей снижение дозы не должно превышать 10 мг/кг массы тела 2 раза в сутки каждые 2 недели.\u003Cbr\u003EСопутствующие противоэпилептические лекарственные препараты (в период перевода пациентов на прием леветирацетама) желательно отменять постепенно.\u003Cbr\u003EИмеющиеся сведения о применении препарата у детей не свидетельствуют о каком-либо его отрицательном влиянии на развитие и половое созревание. Однако отдаленные последствия лечения на способность детей к обучению, их интеллектуальное развитие, рост, функции эндокринных желез, половое развитие и фертильность остаются неизвестными.\u003Cbr\u003EПациентам с заболеваниями почек и декомпенсированными заболеваниями печени рекомендуется исследование функции почек перед началом лечения. При нарушении функции почек может потребоваться коррекция дозы.\u003Cbr\u003EВ связи с имеющимися сообщениями о случаях суицида, суицидальных намерений и попыток суицида при лечении леветирацетамом следует предупреждать пациентов о необходимости немедленно сообщать лечащему врачу о появлении любых симптомов депрессии или суицидальных намерений."},{"name":"Взаимодействие","value":"Препарат не взаимодействует с противоэпилептическими препаратами (фенитоин, карбамазепин, вальпроевая кислота, фенобарбитал, ламотриджин, габапентин и прими дон).\u003Cbr\u003EЛеветирацетам в суточной дозе 1000 мг не изменяет фармакокинетику пероральных противозачаточных средств (этинилэстрадиола и левоноргестрела).\u003Cbr\u003EЛеветирацетам в суточной дозе 2000 мг не изменяет фармакокинетику дигоксина и варфарина.\u003Cbr\u003EДигоксин, пероральные противозачаточные средства и варфарин не влияют на фармакокинетику леветирацетама.\u003Cbr\u003EПри совместном приеме с топираматом выше вероятность развития анорексии.\u003Cbr\u003EПолнота всасывания леветирацетама не изменяется под воздействием пищи, при этом скорость всасывания несколько снижается.\u003Cbr\u003EДанных о взаимодействии леветирацетама с алкоголем нет.\u003Cbr\u003EКлиренс леветирацетама был выше на 20% у детей, принимающих противосудорожные средства - индукторы микросомального окисления в печени, по сравнении с детьми, их не принимающими. Снижение почечной секреции первичного метаболита наблюдалось при приеме пробенецида в дозе 500 мг 4 раза в день."},{"name":"Регистрационный номер","value":"ЛП-002135"},{"name":"Дата государственной регистрации","value":"29.10.2019"},{"name":"Владелец регистрационного удостоверения","value":"Канонфарма продакшн","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["34324371:35649313","7893318:16146766"]}}},{"name":"Изготовитель","value":"Радуга Продакшн"},{"name":"Фасовщик","value":"Радуга Продакшн"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Леветирацетам Канон","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["17796364:18028691"]}}},{"name":"Срок годности","value":"23 мес."}]}},"fullSpecsGrouped":{"7813729754479516860":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"нервная система"},{"name":"Назначение","value":"миоклонические судороги, парциальные судороги, парциальные эпилептические приступы"},{"name":"Показания к применению","value":"В качестве монотерапии (препарат первого выбора) при лечении\u003Cbr\u003Eпарциальных припадков с вторичной генерализацией или без таковой у взрослых и подростков старше 16 лет с вновь диагностированной эпилепсией.\u003Cbr\u003EВ составе комплексной терапии при лечении\u003Cbr\u003Eпарциальных припадков с вторичной генерализацией или без таковой у взрослых и детей старше 6 лет, страдающих эпилепсией;\u003Cbr\u003Eмиоклонических судорог у взрослых и подростков старше 12 лет, страдающих ювенильной миоклонической эпилепсией;\u003Cbr\u003Eпервично-генерализованных судорожных (тонико-клонических) припадков у взрослых и подростков старше 12 лет, страдающих идиопатической генерализованной эпилепсией."},{"name":"Противопоказания","value":"Повышенная чувствительность к леветирацетаму или другим производным пирролидона, а также к любым компонентам препарата;\u003Cbr\u003E- детский возраст до 6 лет (в данной лекарственной форме при лечении парциальных припадков с вторичной генерализацией или без таковой у детей, страдающих эпилепсией);\u003Cbr\u003E- детский возраст до 12 лет (при лечении миоклонических судорог у детей, страдающих ювенильной миоклонической эпилепсией, и при первично-генерализованных судорожных (тонико-клонических) припадках у детей, страдающих идиопатической генерализованной эпилепсией);\u003Cbr\u003E- масса тела менее 20 кг;\u003Cbr\u003E- детский возраст до 16 лет при лечении парциальных припадков с вторичной генерализацией или без таковой с вновь диагностированной эпилепсией;\u003Cbr\u003E- период грудного вскармливания.\u003Cbr\u003EС осторожностью:\u003Cbr\u003E- Пациенты пожилого возраста (старше 65 лет);\u003Cbr\u003E- заболевания печени в стадии декомпенсации;\u003Cbr\u003E- почечная недостаточность (клиренс креатинина менее 50 мл/мин);\u003Cbr\u003E- депрессия, суицидальное поведение;\u003Cbr\u003E- одновременное применение с сульфаниламидами, пробенецидом, нестероидными противовоспалительными средствами, метотрексатом."},{"name":"Состав","value":"1 таблетка, покрытая пленочной оболочкой, содержит: активное вещество: леветирацетам 500 мг; вспомогательные вещества: кремния диоксид коллоидный 6 мг, кроскармеллоза натрия 20 мг, кальция стеарат 6 мг, маннитол 40,4 мг, повидон 12,6 мг, целлюлоза микрокристаллическая 35 мг; состав пленочной оболочки: Опадрай II синий 20 мг, в том числе: поливиниловый спирт 8 мг, макрогол (полиэтиленгликоль) 4,04 мг, тальк 2,96 мг, титана диоксид 4,1 мг, алюминиевый лак на основе красителя индигокармин 0,86 мг, алюминиевый лак на основе красителя красный очаровательный 0,04 мг."},{"name":"Действующее вещество","value":"Леветирацетам"},{"name":"Способ применения и дозы","value":"Внутрь, независимо от приема пищи, запивая достаточным количеством жидкости. Суточную дозу препарата делят на два приема в одинаковой дозе.\u003Cbr\u003EМонотерапия\u003Cbr\u003EВзрослым и подросткам старше 16 лет лечение следует начинать с суточной дозы 500 мг, разделенной на 2 приема (по 250 мг 2 раза в сутки). Через 2 недели доза может быть увеличена до начальной терапевтической - 1000 мг (по 500 мг 2 раза в сутки). Максимальная суточная доза составляет 3000 мг (по 1500 мг 2 раза в сутки).\u003Cbr\u003EВ составе комплексной терапии\u003Cbr\u003EДетям старше 6 лет лечение следует начинать с суточной дозы 20 мг/кг массы тела, разделенной на 2 приема (по 10 мг/кг массы тела 2 раза в сутки). Изменение дозы на 20 мг/кг массы тела может осуществляться каждые 2 недели до достижения рекомендуемой суточной дозы - 60 мг/кг массы тела (по 30 мг/кг массы тела 2 раза в сутки). При непереносимости рекомендуемой суточной дозы возможно ее снижение. Следует применять минимальную эффективную дозы. Врач должен назначить препарат в наиболее подходящей дозировке в зависимости от массы тела пациента и необходимой терапевтической дозы.\u003Cbr\u003EДетям с массой тела более 50 кг дозирование осуществляется по схеме, приведенной для взрослых.\u003Cbr\u003EВзрослым и подросткам старше 16 лет с массой тела более 50 кг лечение следует начинать с суточной дозы 1000 мг, разделенной на 2 приема (по 500 мг 2 раза в сутки). В зависимости от клинической реакции и переносимости препарата суточная доза может быть увеличена до максимальной - 3000 мг (по 1500 мг 2 раза в сутки). Изменение дозы на 500 мг 2 раза в сутки может осуществляться каждые 2-4 недели.\u003Cbr\u003EПоскольку леветирацетам выводится из организма почками, при назначении препарата пациентам с почечной недостаточностью и пациентам пожилого возраста дозу следует корректировать в зависимости от величины клиренса креатинина (КК).\u003Cbr\u003EКлиренс креатинина для мужчин можно рассчитать исходя из концентрации сывороточного креатинина по следующей формуле:\u003Cbr\u003EКК (мл/мин)= (140 - возраст (годы)) х масса тела (кг)/ 72 x ККсыворот (мг/дл)\u003Cbr\u003EКлиренс креатинина для женщин можно рассчитать умножив полученное значение на коэффициент 0,85."},{"name":"Побочные действия","value":"Классификация ВОЗ частоты развития побочных эффектов:\u003Cbr\u003Eочень часто - ≥1/10 назначений (\u003E10%)\u003Cbr\u003Eчасто - от ≥1/100 до \u003C 1/10 назначений (\u003E1% и \u003C10%)\u003Cbr\u003Eнечасто - от ≥1/1000 до \u003C1/100 назначений (\u003E0,1% и \u003C1%)\u003Cbr\u003Eредко - от ≥1/10000 до \u003C1/1000 назначений (\u003E0,01% и \u003C0,1%)\u003Cbr\u003Eочень редко - \u003C1/10000 назначений (\u003C0,01%)\u003Cbr\u003EСо стороны нервной системы и психики\u003Cbr\u003EОчень часто: сонливость, головная боль, астенический синдром.\u003Cbr\u003EЧасто: судороги, головокружение, головная боль, тремор, нарушение равновесия, возбуждение, депрессия, переменчивость настроения, враждебность/агрессивность, бессонница, нервозность, раздражительность, расстройства личности, нарушение мышления, тревога, вертиго.\u003Cbr\u003EНечасто: атаксия, амнезия, снижение концентрации внимания, ухудшение памяти, попытки суицида, суицидальные намерения, психотические расстройства, поведенческие расстройства, галлюцинации, спутанность сознания, эмоциональная лабильность.\u003Cbr\u003EРедко: хореоатетоз, дискинезия, гиперкинезия, суицид, расстройство личности, нарушение мышления.\u003Cbr\u003EСо стороны органов зрения\u003Cbr\u003EНечасто: диплопия, нарушение аккомодации.\u003Cbr\u003EСо стороны дыхательной системы\u003Cbr\u003EЧасто: усиление кашля.\u003Cbr\u003EСо стороны пищеварительной системы\u003Cbr\u003EЧасто: абдоминальная боль, диарея, диспепсия, тошнота, рвота, анорексия, повышение массы тела.\u003Cbr\u003EНечасто: панкреатит, изменения функциональных печеночных проб.\u003Cbr\u003EРедко: печеночная недостаточность, гепатит, снижение массы тела.\u003Cbr\u003EСо стороны кожных покровов\u003Cbr\u003EЧасто: кожная сыпь.\u003Cbr\u003EНечасто: экзема, зуд, алопеция (в ряде случаев восстановление волосяного покрова наблюдалось после отмены препарата).\u003Cbr\u003EРедко: токсический эпидермальный некролиз, Синдром Стивенса-Джонсона, многоформная эритема.\u003Cbr\u003EИзменения лабораторных показателей\u003Cbr\u003EНечасто: тромбоцитопения, лейкопения.\u003Cbr\u003EРедко: нейтропения, панцитопения (в некоторых случаях с угнетением функции костного мозга).\u003Cbr\u003EПрочие\u003Cbr\u003EИнфекции, назофарингит, миалгия, мышечная слабость, склонность к травмам.\u003Cbr\u003EУ детей: рвота, возбуждение, переменчивость настроения, эмоциональная лабильность, агрессивность, поведенческие расстройства, летаргия."},{"name":"Фармакологическое действие","value":"Леветирацетам является производным пирролидона (S-энантиомер α-этил-2-оксо-1-пирролидин-ацетамида), по химической структуре отличается от известных противоэпилептических лекарственных средств. Механизм действия леветирацетама до конца не изучен, но очевидно, что он отличается от механизма действия известных противоэпилептических препаратов. Эксперименты in vitro и in vivo показали, что леветирацетам не влияет на основные характеристики клеток и нормальную трансмиссию. В исследованиях in vitro показано, что он влияет на внутринейрональную концентрацию ионов Са, частично тормозя ток ионов кальция через каналы N-типа и уменьшая высвобождение кальция из внутринейрональных депо. Кроме того он частично восстанавливает токи через ГАМК и глицин-зависимые каналы. Один из предполагаемых механизмов основан на доказанном связывании с гликопротеином синаптических везикул SV2A, содержащемся в сером веществе головного и спинного мозга. Считается, что таким образом реализуется противосудорожный эффект, который выражен в противодействии гиперсинхронизации нейронной активности. Также леветирацетам воздействует на рецепторы ГАМК и глициновые рецепторы, модулируя данные рецепторы через различные эндогенные агенты. Препарат не изменяет нормальную нейротрансмиссию, однако подавляет эпилептиформные нейрональные вспышки, индуцированные ГАМК-агонистом бикукулином, и возбуждение глутаматных рецепторов. Активность препарата подтверждена в отношении как фокальных, так и генерализованных эпилептических припадков (эпилептиформные проявления/фотопароксизмальная реакция)."},{"name":"Фармакологическая группа","value":"противоэпилептические средства"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 6 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"В сухом, защищенном от света месте, при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы: сонливость, ажитация, агрессивность, угнетение сознания, угнетение дыхания, кома.\u003Cbr\u003EЛечение: в остром периоде - искусственный вызов рвоты и промывание желудка с последующим назначением активированного угля. Специфического антидота для леветирацетама нет. При необходимости проводится симптоматическое лечение в условиях стационара с использованием гемодиализа (эффективность диализа для леветирацетама составляет 60%, для его первичного метаболита - 74%)."},{"name":"Применение при беременности и кормлении грудью","value":"Адекватных и строго контролируемых клинических исследований по безопасности применения леветирацетама у беременных не проводилось, поэтому препарат не следует назначать во время беременности, за исключением случаев крайней необходимости. Необходимо соблюдать контрацепцию женщинам с сохраненным детородным потенциалом.\u003Cbr\u003EФизиологические изменения в организме женщины во время беременности могут влиять на концентрацию в плазме леветирацетама, так же, как и других противоэпилептических препаратов. Во время беременности отмечено снижение концентрации леветирацетама в плазме. Это снижение более выражено в третьем триместре (до 60% от базовой концентрации в период, предшествующий беременности).\u003Cbr\u003EЛечение леветирацетамом беременных следует проводить под особым контролем. Перерывы в проведении противоэпилептической терапии могут привести к ухудшению течения заболевания, что может нанести вред здоровью как матери, так и плода. Леветирацетам выделяется с грудным молоком, поэтому грудное вскармливание при лечении препаратом противопоказано."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Влияние препарата леветирацетама на способность к вождению автотранспорта и управлению механизмами специально не изучалось. Тем не менее, в силу различной индивидуальной чувствительности к препарату со стороны центральной нервной системы в период лечения, необходимо воздерживаться от вождения автотранспорта и занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"Если требуется прекратить прием препарата, то отмену лечения рекомендуется осуществлять постепенно (уменьшая разовую дозу на 500 мг каждые 2-4 недели). У детей снижение дозы не должно превышать 10 мг/кг массы тела 2 раза в сутки каждые 2 недели.\u003Cbr\u003EСопутствующие противоэпилептические лекарственные препараты (в период перевода пациентов на прием леветирацетама) желательно отменять постепенно.\u003Cbr\u003EИмеющиеся сведения о применении препарата у детей не свидетельствуют о каком-либо его отрицательном влиянии на развитие и половое созревание. Однако отдаленные последствия лечения на способность детей к обучению, их интеллектуальное развитие, рост, функции эндокринных желез, половое развитие и фертильность остаются неизвестными.\u003Cbr\u003EПациентам с заболеваниями почек и декомпенсированными заболеваниями печени рекомендуется исследование функции почек перед началом лечения. При нарушении функции почек может потребоваться коррекция дозы.\u003Cbr\u003EВ связи с имеющимися сообщениями о случаях суицида, суицидальных намерений и попыток суицида при лечении леветирацетамом следует предупреждать пациентов о необходимости немедленно сообщать лечащему врачу о появлении любых симптомов депрессии или суицидальных намерений."},{"name":"Взаимодействие","value":"Препарат не взаимодействует с противоэпилептическими препаратами (фенитоин, карбамазепин, вальпроевая кислота, фенобарбитал, ламотриджин, габапентин и прими дон).\u003Cbr\u003EЛеветирацетам в суточной дозе 1000 мг не изменяет фармакокинетику пероральных противозачаточных средств (этинилэстрадиола и левоноргестрела).\u003Cbr\u003EЛеветирацетам в суточной дозе 2000 мг не изменяет фармакокинетику дигоксина и варфарина.\u003Cbr\u003EДигоксин, пероральные противозачаточные средства и варфарин не влияют на фармакокинетику леветирацетама.\u003Cbr\u003EПри совместном приеме с топираматом выше вероятность развития анорексии.\u003Cbr\u003EПолнота всасывания леветирацетама не изменяется под воздействием пищи, при этом скорость всасывания несколько снижается.\u003Cbr\u003EДанных о взаимодействии леветирацетама с алкоголем нет.\u003Cbr\u003EКлиренс леветирацетама был выше на 20% у детей, принимающих противосудорожные средства - индукторы микросомального окисления в печени, по сравнении с детьми, их не принимающими. Снижение почечной секреции первичного метаболита наблюдалось при приеме пробенецида в дозе 500 мг 4 раза в день."},{"name":"Регистрационный номер","value":"ЛП-002135"},{"name":"Дата государственной регистрации","value":"29.10.2019"},{"name":"Владелец регистрационного удостоверения","value":"Канонфарма продакшн"},{"name":"Изготовитель","value":"Радуга Продакшн"},{"name":"Фасовщик","value":"Радуга Продакшн"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Леветирацетам Канон"},{"name":"Срок годности","value":"23 мес."}]}],"transitionId":"tr_12130669367976342386"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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1 438 ₽

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POLZAru
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    Леветирацетам Канон таб. п/о плен., 250 мг, 30 шт.

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  • Леветирацетам таб. п/о плен., 250 мг, 30 шт.
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    Леветирацетам таб. п/о плен., 250 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 527 ₽
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  • Сертралин Канон таб. п/о плен., 50 мг, 30 шт.
    –15 %
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    Сертралин Канон таб. п/о плен., 50 мг, 30 шт.

    Цена 287 ₽ вместо 337
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  • Бетагистин Канон таб., 8 мг, 30 шт.
    –30 %
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    Бетагистин Канон таб., 8 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 114 ₽ вместо 164
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  • Леветирацетам-Алиум таб. п/о плен., 250 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-24mbjjt7lir/toggleWishlist":{"skuId":"101640945949","productId":1734838337,"offerId":"ksQL4rvA1Glly-U0-VRLxQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhqD62qqcq5chEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIwZCeuwYQnYKX0voCGLGLuggg7dnBBw==","sign":"uG4lQuVrB5hTnugFry3zLoKaD2BNINUwRNcSwePbQMg="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-24mbjjt7lir/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Леветирацетам-Алиум таб. п/о плен., 250 мг, 30 шт.

    Рейтинг товара: 3 из 5
    на основе 1 оценка
    Цена 543 ₽
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-24mbjjt7lir/addToCartButton":{"offerId":"ksQL4rvA1Glly-U0-VRLxQ","skuId":"101640945949","pendingCartItem":{"productId":1734838337,"offerId":"ksQL4rvA1Glly-U0-VRLxQ","showPlaceId":"OTNDnItfwRMjN9MRHuEMMrUkvoB7yxhJ2ONnM2gykU8AoD3ON1R1i-LZjK9u-8e3fax-thW19VShvL_L23aRY_ABixH9zVCE1xZHWKtMwxje2sH_s68UC2WrfCe3Epy4FPrJ0lFhyxMsUBqoBM4z9h7qEgV4MOAEQq9_kfmAkRCUvQcgbX5DyUf7pHbS5zzWJ2KaOfFwXVa9xLoZ8XP1RA,,","feeShow":"OTNDnItfwRMjN9MRHuEMMrUkvoB7yxhJ2ONnM2gykU8AoD3ON1R1i-LZjK9u-8e3fax-thW19VShvL_L23aRY_ABixH9zVCE1xZHWKtMwxje2sH_s68UC2WrfCe3Epy4FPrJ0lFhyxMsUBqoBM4z9h7qEgV4MOAEQq9_kfmAkRCUvQcgbX5DyUf7pHbS5zzWJ2KaOfFwXVa9xLoZ8XP1RA,,","skuId":"101640945949","shopId":55106433,"price":{"applicablePriceDiscounts":[],"value":"543","currency":"RUR"},"hid":"15756525","name":"Леветирацетам-Алиум таб. п/о плен., 250 мг, 30 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  • Тофизопам Канон таб., 50 мг, 60 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-nk3g2s0rf4/toggleWishlist":{"skuId":"101622662466","productId":1698394700,"offerId":"kmxFaDBpq0rhLC9thZsxug","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhqD62qqcq5chEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIzOTtqQYQwoq7yfoCGM7C2Qcg7dnBBw==","sign":"OdQMkN+Ek/my3CIVgV4yfK5aXhsgW8nO5B5tm2Cut5Q="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-nk3g2s0rf4/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Тофизопам Канон таб., 50 мг, 60 шт.

    Рейтинг товара: 5 из 5
    на основе 9 оценок
    Цена 601 ₽
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  • Леветирацетам-Алиум таб. п.п.о, 500 мг, 60 шт.
    –21 %
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    Леветирацетам-Алиум таб. п.п.о, 500 мг, 60 шт.

    Цена 1 772 ₽ вместо 2 243
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  • Гидроксизин Канон таб. п/о плен., 25 мг, 25 шт.
    –31 %
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    Гидроксизин Канон таб. п/о плен., 25 мг, 25 шт.

    Рейтинг товара: 4.7 из 5
    на основе 6 оценок
    Цена 112 ₽ вместо 162
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  • Винпотропил таб. п/о плен., 10 мг+800 мг, 30 шт.
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    Винпотропил таб. п/о плен., 10 мг+800 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 387 ₽
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  • Ламотриджин Канон таб., 25 мг, 30 шт.
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    Ламотриджин Канон таб., 25 мг, 30 шт.

    Рейтинг товара: 4.8 из 5
    на основе 56 оценок
    Цена 315 ₽
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  • Мемантин Канон таб. п/о плен., 10 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ixk0b1jr4i7/toggleWishlist":{"skuId":"186523790","productId":1404748431,"offerId":"fLwb1T9yvvd5L0tp76COjQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhqD62qqcq5chEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIj4XrnQUQjsH4WBjOwtkHIO3ZwQc=","sign":"FMhl7RPklYhN+Fsxw6GVIbCSNNoEh732kuoUwnwsKUY="},"waitWishlistCollections":false}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ixk0b1jr4i7/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Мемантин Канон таб. п/о плен., 10 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 49 оценок
    Цена 446 ₽
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  • Топирамат Канон таб. п/о плен., 25 мг, 28 шт.
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    Топирамат Канон таб. п/о плен., 25 мг, 28 шт.

    Рейтинг товара: 4.7 из 5
    на основе 21 оценка
    Цена 235 ₽
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Инструкция

Показания к применению

В качестве монотерапии (препарат первого выбора) при лечении
парциальных припадков с вторичной генерализацией или без таковой у взрослых и подростков старше 16 лет с вновь диагностированной эпилепсией.
В составе комплексной терапии при лечении
парциальных припадков с вторичной генерализацией или без таковой у взрослых и детей старше 6 лет, страдающих эпилепсией;
миоклонических судорог у взрослых и подростков старше 12 лет, страдающих ювенильной миоклонической эпилепсией;
первично-генерализованных судорожных (тонико-клонических) припадков у взрослых и подростков старше 12 лет, страдающих идиопатической генерализованной эпилепсией.

Противопоказания

Повышенная чувствительность к леветирацетаму или другим производным пирролидона, а также к любым компонентам препарата;
- детский возраст до 6 лет (в данной лекарственной форме при лечении парциальных припадков с вторичной генерализацией или без таковой у детей, страдающих эпилепсией);
- детский возраст до 12 лет (при лечении миоклонических судорог у детей, страдающих ювенильной миоклонической эпилепсией, и при первично-генерализованных судорожных (тонико-клонических) припадках у детей, страдающих идиопатической генерализованной эпилепсией);
- масса тела менее 20 кг;
- детский возраст до 16 лет при лечении парциальных припадков с вторичной генерализацией или без таковой с вновь диагностированной эпилепсией;
- период грудного вскармливания.
С осторожностью:
- Пациенты пожилого возраста (старше 65 лет);
- заболевания печени в стадии декомпенсации;
- почечная недостаточность (клиренс креатинина менее 50 мл/мин);
- депрессия, суицидальное поведение;
- одновременное применение с сульфаниламидами, пробенецидом, нестероидными противовоспалительными средствами, метотрексатом.

Способ применения и дозы

Внутрь, независимо от приема пищи, запивая достаточным количеством жидкости. Суточную дозу препарата делят на два приема в одинаковой дозе.
Монотерапия
Взрослым и подросткам старше 16 лет лечение следует начинать с суточной дозы 500 мг, разделенной на 2 приема (по 250 мг 2 раза в сутки). Через 2 недели доза может быть увеличена до начальной терапевтической - 1000 мг (по 500 мг 2 раза в сутки). Максимальная суточная доза составляет 3000 мг (по 1500 мг 2 раза в сутки).
В составе комплексной терапии
Детям старше 6 лет лечение следует начинать с суточной дозы 20 мг/кг массы тела, разделенной на 2 приема (по 10 мг/кг массы тела 2 раза в сутки). Изменение дозы на 20 мг/кг массы тела может осуществляться каждые 2 недели до достижения рекомендуемой суточной дозы - 60 мг/кг массы тела (по 30 мг/кг массы тела 2 раза в сутки). При непереносимости рекомендуемой суточной дозы возможно ее снижение. Следует применять минимальную эффективную дозы. Врач должен назначить препарат в наиболее подходящей дозировке в зависимости от массы тела пациента и необходимой терапевтической дозы.
Детям с массой тела более 50 кг дозирование осуществляется по схеме, приведенной для взрослых.
Взрослым и подросткам старше 16 лет с массой тела более 50 кг лечение следует начинать с суточной дозы 1000 мг, разделенной на 2 приема (по 500 мг 2 раза в сутки). В зависимости от клинической реакции и переносимости препарата суточная доза может быть увеличена до максимальной - 3000 мг (по 1500 мг 2 раза в сутки). Изменение дозы на 500 мг 2 раза в сутки может осуществляться каждые 2-4 недели.
Поскольку леветирацетам выводится из организма почками, при назначении препарата пациентам с почечной недостаточностью и пациентам пожилого возраста дозу следует корректировать в зависимости от величины клиренса креатинина (КК).
Клиренс креатинина для мужчин можно рассчитать исходя из концентрации сывороточного креатинина по следующей формуле:
КК (мл/мин)= (140 - возраст (годы)) х масса тела (кг)/ 72 x ККсыворот (мг/дл)
Клиренс креатинина для женщин можно рассчитать умножив полученное значение на коэффициент 0,85.
Полная инструкция
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Леветирацетам Канон таб. п/о плен.
Леветирацетам Канон таб. п/о плен., 500 мг, 60 шт.
4.9
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4.9
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У продавца:17 оценок·3 отзыва
У всех продавцов:26 оценок·8 отзывов
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user avatar
9 месяцев назад • mila mila • Куплен на Маркете
Достоинства: Приступы стали помягче.
Недостатки: Большие таблетки, неудобно глотать.
Комментарий: В целом хорошее лекарство.
user avatar
Год назад • Юлёна • Куплен на Маркете
Достоинства: Быстрая доставка, приемлемая цена.
Недостатки: Нет
Комментарий: Это жизненно важный препарат, поэтому достоинства расписывать не стоит.
user avatar
4 месяца назад • Имя скрыто • Куплен на Маркете
Достоинства: Качество
Недостатки: Нет
Посмотреть все отзывы на Маркете
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