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Описание

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Адеметионин таб. кш/раств., 400 мг, 40 шт.

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4.9
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Коротко о товаре

Артикул Маркета
414936953
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
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В случае если таблетки имеют цвет, отличный от белого до белого с желтоватым оттенком цвета (вследствие негерметичности упаковки), препарат применять не рекомендуется.\u003Cbr /\u003EРекомендуемая доза составляет 10-25 мг адеметионина на 1 кг массы тела в сутки.\u003Cbr /\u003EОбычно суточная доза составляет 1 -2 таблетки в сутки (от 400-800 мг адеметионина в сутки) и может быть увеличена до 4 таблеток в сутки (до 1600 мг адеметионина в сутки). Эффект обычно проявляется через 7-14 дней лечения и сохраняется при дальнейшем применении препарата.\u003Cbr /\u003EПри отсутствии положительного эффекта от проводимой в течение 2 недель терапии препаратом или ухудшении состояния следует обратиться к врачу.\u003Cbr /\u003EПациенты пожилого возраста\u003Cbr /\u003EКлинический опыт применения адеметионина не выявил каких-либо различий в его эффективности у пациентов пожилого возраста и пациентов более молодого возраста. Однако, учитывая высокую вероятность имеющихся нарушений функции печени, почек или сердца, другой сопутствующей патологии или одновременной терапии с другими лекарственными средствами, дозу препарата пожилым пациентам следует подбирать с осторожностью, начиная применение препарата с нижнего предела диапазона доз.\u003Cbr /\u003EПочечная недостаточность\u003Cbr /\u003EИмеются ограниченные клинические данные о применении адеметионина у пациентов с почечной недостаточностью, в связи с этим рекомендуется соблюдать осторожность при применении препарата у таких пациентов.\u003Cbr /\u003EПеченочная недостаточность\u003Cbr /\u003EПараметры фармакокинетики адеметионина сходны у здоровых добровольцев и у пациентов с хроническими заболеваниями печени.\u003Cbr /\u003EДети и подростки до 18 лет\u003Cbr /\u003EПрименение адеметионина у детей и подростков до 18 лет противопоказано (эффективность и безопасность не установлены)."},{"name":"Побочные действия","value":"Среди наиболее частых нежелательных реакций, исследований с участием примерно 2000 пациентов, были: головная боль, тошнота и диарея.\u003Cbr /\u003EНиже приведены данные о нежелательных реакциях, наблюдавшихся в ходе клинических исследований (n=1922) и в пострегистрационном периоде наблюдения («спонтанные» сообщения).\u003Cbr /\u003EНежелательные реакции распределены по системно-органным классам и частоте их возникновения: очень часто (\u003E1/10); часто (\u003E1/100, \u003C1/10); нечасто (\u003E1/1000, \u003C1/100); редко (\u003E1/10000, \u003C1/1000); очень редко (\u003C 1/10000).\u003Cbr /\u003EИнфекционные и паразитарные заболевания: нечасто - инфекции мочевыводящих путей.\u003Cbr /\u003EНарушения со стороны иммунной системы: нечасто - реакции гиперчувствительности, анафилактоидные или анафилактические реакции (в том числе покраснение кожных покровов, одышка, бронхоспазм, боль в спине, ощущение дискомфорта в области грудной клетки, изменение артериального давления (снижение артериального давления, повышение артериального давления) или частоты пульса (учащение, урежение)).\u003Cbr /\u003EНарушение психики: часто - тревога, бессонница; нечасто - ажитация (сильное эмоциональное возбуждение, сопровождающееся двигательным беспокойством), спутанность сознания.\u003Cbr /\u003EНарушения со стороны нервной системы: часто - головная боль; нечасто - головокружение, парестезия, дисгевзия (расстройства вкуса, характеризующиеся утратой вкуса или извращением вкусовых восприятий).\u003Cbr /\u003EНарушения со стороны сосудов: нечасто - «приливы», снижение артериального давления, флебит.\u003Cbr /\u003EНарушения со стороны дыхательной системы, органов грудной клетки и средостения: нечасто - отек гортани.\u003Cbr /\u003EНарушения со стороны желудочно-кишечного тракта: часто - боль в животе, диарея, тошнота; нечасто - сухость во рту, диспепсия, метеоризм, желудочно-кишечная боль, желудочно-кишечные расстройства, желудочно-кишечное кровотечение, рвота, эзофагит; редко - вздутие живота.\u003Cbr /\u003EНарушения со стороны кожи и подкожных тканей: часто - кожный зуд; нечасто - повышенное потоотделение, ангионевротический отек, кожно-аллергические реакции (в том числе сыпь, кожный зуд, крапивница, эритема).\u003Cbr /\u003EНарушения со стороны скелетно-мышечной и соединительной ткани: нечасто - артралгия, мышечные спазмы.\u003Cbr /\u003EОбщие расстройства и нарушения в месте введения: часто - астения; нечасто - отек, лихорадка, озноб; редко - недомогание.\u003Cbr /\u003EЕсли у Вас отмечаются нежелательные реакции, указанные в инструкции, или они усугубляются, или Вы заметили любые другие нежелательные реакции, не указанные в инструкции, сообщите об этом врачу."},{"name":"Фармакологическое действие","value":"Адеметионин относится к группе гепатопротекторов. Оказывает желчегонное действие, обладает детоксикационными, регенерирующими, антиоксидантными, антифиброзирующими и нейропротективными свойствами.\nАдеметионин (S-аденозил-L-метионин) - это аминокислота естественного происхождения, которая присутствует практически во всех тканях и биологических жидкостях в организме. Наибольшая концентрация адеметионина отмечена в печени и мозге. Адеметионин является производным серосодержащей аминокислоты-метионина. Выполняет ключевую роль в метаболических процессах организма, принимает участие в важных биохимических реакциях. Участвует в синтезе фосфолипидов клеточных мембран, нейротрансмиттеров, нуклеиновых кислот, белков, гормонов и др. Адеметионин является предшественником цистеина, таурина, глутатиона (обеспечивая окислительно-восстановительный механизм клеточной детоксикации), коэнзима А (включается в биохимические реакции цикла трикарбоновых кислот и восполняет энергетический потенциал клетки). Повышает содержание глутамина в печени, цистеина и таурина в плазме; снижает содержание метионина в сыворотке, нормализуя метаболические реакции в печени. Опосредованно участвует в стимуляции регенерации и пролиферации клеток печени, что уменьшает риск фиброзирования. Адеметионин нормализует синтез эндогенного фосфатидилхолина в гепатоцитах, что повышает текучесть и поляризацию мембран. Это улучшает функцию ассоциированных с мембранами гепатоцитов транспортных систем желчных кислот и способствует пассажу желчных кислот в желчевыводящие пути. Эффективен при внутридольковом варианте холестаза (нарушение синтеза и тока желчи). Адеметионин снижает токсичность желчных кислот в клетках печени. У пациентов с диффузными заболеваниями печени (цирроз, гепатит) адеметионин снижает выраженность кожного зуда и способствует улучшению биохимических показателей крови, в т.ч. концентрации прямого билирубина, активности щелочной фосфатазы, аминотрансфераз и др. Желчегонный и гепатопротекторный эффект сохраняется до 3 месяцев после прекращения лечения. Показана эффективность при гепатопатиях, обусловленных различными гепатотоксичными препаратами. В ряде исследований была подтверждена эффективность адеметионина при лечении повышенной утомляемости у пациентов с хроническими заболеваниями печени."},{"name":"Фармакологическая группа","value":"прочие препараты для желудочно-кишечного тракта и обмена веществ, аминокислоты и их производные"},{"name":"Форма выпуска","value":"таблетки, покрытые кишечнорастворимой оболочкой"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"При температуре не выше 25 °С. Хранить в местах, недоступных для детей."},{"name":"Передозировка","value":"Передозировка препаратом маловероятна. В случае передозировки следует немедленно обратиться к врачу. Лечение: симптоматическое."},{"name":"Применение при беременности и кормлении грудью","value":"Применение препарата при беременности и в период грудного вскармливания не рекомендуется без наблюдения у врача."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"При приеме адеметионина возможны головокружение и снижение артериального давления. В случае появления данных нежелательных реакций следует воздержаться от управления транспортными средствами и механизмами до их исчезновения."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr /\u003EОдновременный прием с селективными ингибиторами обратного захвата серотонина (СИОЗС), трициклическими антидепрессантами (такими как кломипрамин), а также лекарственными средствами, содержащими триптофан, в том числе, растительного происхождения (см. раздел «Взаимодействие с другими лекарственными средствами»).\u003Cbr /\u003EПожилой возраст.\u003Cbr /\u003EПочечная недостаточность.\u003Cbr /\u003EНеобходимо обратиться к врачу при отсутствии улучшения или ухудшения состояния. Учитывая тонизирующий эффект препарата, не рекомендуется принимать его перед сном. При применении препарата пациентам с циррозом печени на фоне гиперазотемии необходим систематический контроль содержания азота в крови. Во время длительной терапии необходимо определять концентрацию мочевины и креатинина в плазме крови. Пациентам с депрессией или получающих антидепрессанты следует обратиться к врачу перед началом приема препарата. Имеются сообщения о внезапном появлении или нарастании тревоги у пациентов, принимающих адеметионин. В большинстве случаев прекращения приема препарата не требуется, в нескольких случаях тревога исчезала после снижения дозы или отмены препарата.\u003Cbr /\u003EПоскольку дефицит цианокобаламина (витамина В12) и фолиевой кислоты может снизить содержание адеметионина у пациентов группы риска (с анемией, заболеваниями печени, при беременности или вероятностью витаминной недостаточности, в связи с другими заболеваниями или диетой, например, у вегетарианцев), следует контролировать содержание витаминов в плазме крови. Если недостаточность обнаружена, рекомендован прием витаминов (цианокобаламина и фолиевой кислоты) до начала лечения адеметионином или одновременный прием с адеметионином.\u003Cbr /\u003EПри иммунологическом анализе применение адеметионина может способствовать ложному определению показателя высокого содержания гомоцистеина в крови.\u003Cbr /\u003EДля пациентов, принимающих адеметионин, рекомендовано использовать неиммунологические методы анализа для определения содержания гомоцистеина."},{"name":"Взаимодействие","value":"Известных взаимодействий с другими лекарственными средствами не наблюдалось. Если Вы применяете нижеперечисленные или другие лекарственные препараты (в том числе безрецептурные) перед применением препарата проконсультируйтесь с врачом. Есть сообщение о синдроме избытка серотонина у пациента, принимавшего адеметионин и кломипрамин. Считается, что такое взаимодействие возможно, и следует с осторожностью применять адеметионин вместе с селективными ингибиторами обратного захвата серотонина, трициклическими антидепрессантами (такими как кломипрамин), а также лекарственными средствами, содержащими триптофан (в том числе, растительного происхождения)."},{"name":"Регистрационный номер","value":"ЛП-007320"},{"name":"Дата государственной регистрации","value":"24.08.2021"},{"name":"Владелец регистрационного удостоверения","value":"Велфарм","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["34324371:35649313","7893318:16127911"]}}},{"name":"Изготовитель","value":"Велфарм"},{"name":"Фасовщик","value":"Велфарм"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Срок годности","value":"1 г."}]}},"fullSpecsGrouped":{"12613852379968487687":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Органы и системы","value":"печень, пищеварительная система"},{"name":"Назначение","value":"нарушение функции печени, поддержание работы печени, хронические воспалительные заболевания печени"},{"name":"Показания к применению","value":"- вспомогательная терапия при установленных хронических заболеваниях печени, для улучшения и поддержания ее функций;\u003Cbr /\u003E- повышенная утомляемость при установленных хронических заболеваниях печени."},{"name":"Противопоказания","value":"- генетические нарушения, влияющие на метиониновый цикл и/или вызывающие гомоцистинурию и/или гипергомоцистеинемию (дефицит цистатионин бетасинтазы, нарушение метаболизма витамина В12).\u003Cbr /\u003E- повышенная чувствительность к любому из компонентов препарата;\u003Cbr /\u003E- возраст до 18 лет (в связи с отсутствием данных по эффективности и безопасности применения адеметионина в данной возрастной популяции);\u003Cbr /\u003E- биполярные расстройства."},{"name":"Состав","value":"Состав на одну таблетку:\u003Cbr /\u003EДействующее вещество: адеметионина 1,4-бутандисульфонат - 760,0 мг (в пересчете на адеметионин-ион - 400,0 мг).\u003Cbr /\u003EВспомогательные вещества: кремния диоксид коллоидный (аэросил), магния стеарат, карбоксиметилкрахмал натрия (натрия крахмал гликолят, примогель), целлюлоза микрокристаллическая (112).\u003Cbr /\u003EСостав оболочки: кишечнорастворимое пленочное покрытие (ACRYL-EZE 93А18597 белый), содержащее метакриловой кислоты и этилакрилата сополимер (1:1), тальк, титана диоксид, кремния диоксид коллоидный, натрия бикарбонат, натрия лаурилсульфат; триэтил цитрат."},{"name":"Действующее вещество","value":"Адеметионин"},{"name":"Способ применения и дозы","value":"Внутрь.\u003Cbr /\u003EТаблетки следует принимать целиком, не разжевывая, желательно в первой половине дня между приемами пищи.\u003Cbr /\u003EТаблетки адеметионина следует вынимать из упаковки непосредственно перед приемом внутрь. В случае если таблетки имеют цвет, отличный от белого до белого с желтоватым оттенком цвета (вследствие негерметичности упаковки), препарат применять не рекомендуется.\u003Cbr /\u003EРекомендуемая доза составляет 10-25 мг адеметионина на 1 кг массы тела в сутки.\u003Cbr /\u003EОбычно суточная доза составляет 1 -2 таблетки в сутки (от 400-800 мг адеметионина в сутки) и может быть увеличена до 4 таблеток в сутки (до 1600 мг адеметионина в сутки). Эффект обычно проявляется через 7-14 дней лечения и сохраняется при дальнейшем применении препарата.\u003Cbr /\u003EПри отсутствии положительного эффекта от проводимой в течение 2 недель терапии препаратом или ухудшении состояния следует обратиться к врачу.\u003Cbr /\u003EПациенты пожилого возраста\u003Cbr /\u003EКлинический опыт применения адеметионина не выявил каких-либо различий в его эффективности у пациентов пожилого возраста и пациентов более молодого возраста. Однако, учитывая высокую вероятность имеющихся нарушений функции печени, почек или сердца, другой сопутствующей патологии или одновременной терапии с другими лекарственными средствами, дозу препарата пожилым пациентам следует подбирать с осторожностью, начиная применение препарата с нижнего предела диапазона доз.\u003Cbr /\u003EПочечная недостаточность\u003Cbr /\u003EИмеются ограниченные клинические данные о применении адеметионина у пациентов с почечной недостаточностью, в связи с этим рекомендуется соблюдать осторожность при применении препарата у таких пациентов.\u003Cbr /\u003EПеченочная недостаточность\u003Cbr /\u003EПараметры фармакокинетики адеметионина сходны у здоровых добровольцев и у пациентов с хроническими заболеваниями печени.\u003Cbr /\u003EДети и подростки до 18 лет\u003Cbr /\u003EПрименение адеметионина у детей и подростков до 18 лет противопоказано (эффективность и безопасность не установлены)."},{"name":"Побочные действия","value":"Среди наиболее частых нежелательных реакций, исследований с участием примерно 2000 пациентов, были: головная боль, тошнота и диарея.\u003Cbr /\u003EНиже приведены данные о нежелательных реакциях, наблюдавшихся в ходе клинических исследований (n=1922) и в пострегистрационном периоде наблюдения («спонтанные» сообщения).\u003Cbr /\u003EНежелательные реакции распределены по системно-органным классам и частоте их возникновения: очень часто (\u003E1/10); часто (\u003E1/100, \u003C1/10); нечасто (\u003E1/1000, \u003C1/100); редко (\u003E1/10000, \u003C1/1000); очень редко (\u003C 1/10000).\u003Cbr /\u003EИнфекционные и паразитарные заболевания: нечасто - инфекции мочевыводящих путей.\u003Cbr /\u003EНарушения со стороны иммунной системы: нечасто - реакции гиперчувствительности, анафилактоидные или анафилактические реакции (в том числе покраснение кожных покровов, одышка, бронхоспазм, боль в спине, ощущение дискомфорта в области грудной клетки, изменение артериального давления (снижение артериального давления, повышение артериального давления) или частоты пульса (учащение, урежение)).\u003Cbr /\u003EНарушение психики: часто - тревога, бессонница; нечасто - ажитация (сильное эмоциональное возбуждение, сопровождающееся двигательным беспокойством), спутанность сознания.\u003Cbr /\u003EНарушения со стороны нервной системы: часто - головная боль; нечасто - головокружение, парестезия, дисгевзия (расстройства вкуса, характеризующиеся утратой вкуса или извращением вкусовых восприятий).\u003Cbr /\u003EНарушения со стороны сосудов: нечасто - «приливы», снижение артериального давления, флебит.\u003Cbr /\u003EНарушения со стороны дыхательной системы, органов грудной клетки и средостения: нечасто - отек гортани.\u003Cbr /\u003EНарушения со стороны желудочно-кишечного тракта: часто - боль в животе, диарея, тошнота; нечасто - сухость во рту, диспепсия, метеоризм, желудочно-кишечная боль, желудочно-кишечные расстройства, желудочно-кишечное кровотечение, рвота, эзофагит; редко - вздутие живота.\u003Cbr /\u003EНарушения со стороны кожи и подкожных тканей: часто - кожный зуд; нечасто - повышенное потоотделение, ангионевротический отек, кожно-аллергические реакции (в том числе сыпь, кожный зуд, крапивница, эритема).\u003Cbr /\u003EНарушения со стороны скелетно-мышечной и соединительной ткани: нечасто - артралгия, мышечные спазмы.\u003Cbr /\u003EОбщие расстройства и нарушения в месте введения: часто - астения; нечасто - отек, лихорадка, озноб; редко - недомогание.\u003Cbr /\u003EЕсли у Вас отмечаются нежелательные реакции, указанные в инструкции, или они усугубляются, или Вы заметили любые другие нежелательные реакции, не указанные в инструкции, сообщите об этом врачу."},{"name":"Фармакологическое действие","value":"Адеметионин относится к группе гепатопротекторов. Оказывает желчегонное действие, обладает детоксикационными, регенерирующими, антиоксидантными, антифиброзирующими и нейропротективными свойствами.\nАдеметионин (S-аденозил-L-метионин) - это аминокислота естественного происхождения, которая присутствует практически во всех тканях и биологических жидкостях в организме. Наибольшая концентрация адеметионина отмечена в печени и мозге. Адеметионин является производным серосодержащей аминокислоты-метионина. Выполняет ключевую роль в метаболических процессах организма, принимает участие в важных биохимических реакциях. Участвует в синтезе фосфолипидов клеточных мембран, нейротрансмиттеров, нуклеиновых кислот, белков, гормонов и др. Адеметионин является предшественником цистеина, таурина, глутатиона (обеспечивая окислительно-восстановительный механизм клеточной детоксикации), коэнзима А (включается в биохимические реакции цикла трикарбоновых кислот и восполняет энергетический потенциал клетки). Повышает содержание глутамина в печени, цистеина и таурина в плазме; снижает содержание метионина в сыворотке, нормализуя метаболические реакции в печени. Опосредованно участвует в стимуляции регенерации и пролиферации клеток печени, что уменьшает риск фиброзирования. Адеметионин нормализует синтез эндогенного фосфатидилхолина в гепатоцитах, что повышает текучесть и поляризацию мембран. Это улучшает функцию ассоциированных с мембранами гепатоцитов транспортных систем желчных кислот и способствует пассажу желчных кислот в желчевыводящие пути. Эффективен при внутридольковом варианте холестаза (нарушение синтеза и тока желчи). Адеметионин снижает токсичность желчных кислот в клетках печени. У пациентов с диффузными заболеваниями печени (цирроз, гепатит) адеметионин снижает выраженность кожного зуда и способствует улучшению биохимических показателей крови, в т.ч. концентрации прямого билирубина, активности щелочной фосфатазы, аминотрансфераз и др. Желчегонный и гепатопротекторный эффект сохраняется до 3 месяцев после прекращения лечения. Показана эффективность при гепатопатиях, обусловленных различными гепатотоксичными препаратами. В ряде исследований была подтверждена эффективность адеметионина при лечении повышенной утомляемости у пациентов с хроническими заболеваниями печени."},{"name":"Фармакологическая группа","value":"прочие препараты для желудочно-кишечного тракта и обмена веществ, аминокислоты и их производные"},{"name":"Форма выпуска","value":"таблетки, покрытые кишечнорастворимой оболочкой"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"При температуре не выше 25 °С. Хранить в местах, недоступных для детей."},{"name":"Передозировка","value":"Передозировка препаратом маловероятна. В случае передозировки следует немедленно обратиться к врачу. Лечение: симптоматическое."},{"name":"Применение при беременности и кормлении грудью","value":"Применение препарата при беременности и в период грудного вскармливания не рекомендуется без наблюдения у врача."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"При приеме адеметионина возможны головокружение и снижение артериального давления. В случае появления данных нежелательных реакций следует воздержаться от управления транспортными средствами и механизмами до их исчезновения."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr /\u003EОдновременный прием с селективными ингибиторами обратного захвата серотонина (СИОЗС), трициклическими антидепрессантами (такими как кломипрамин), а также лекарственными средствами, содержащими триптофан, в том числе, растительного происхождения (см. раздел «Взаимодействие с другими лекарственными средствами»).\u003Cbr /\u003EПожилой возраст.\u003Cbr /\u003EПочечная недостаточность.\u003Cbr /\u003EНеобходимо обратиться к врачу при отсутствии улучшения или ухудшения состояния. Учитывая тонизирующий эффект препарата, не рекомендуется принимать его перед сном. При применении препарата пациентам с циррозом печени на фоне гиперазотемии необходим систематический контроль содержания азота в крови. Во время длительной терапии необходимо определять концентрацию мочевины и креатинина в плазме крови. Пациентам с депрессией или получающих антидепрессанты следует обратиться к врачу перед началом приема препарата. Имеются сообщения о внезапном появлении или нарастании тревоги у пациентов, принимающих адеметионин. В большинстве случаев прекращения приема препарата не требуется, в нескольких случаях тревога исчезала после снижения дозы или отмены препарата.\u003Cbr /\u003EПоскольку дефицит цианокобаламина (витамина В12) и фолиевой кислоты может снизить содержание адеметионина у пациентов группы риска (с анемией, заболеваниями печени, при беременности или вероятностью витаминной недостаточности, в связи с другими заболеваниями или диетой, например, у вегетарианцев), следует контролировать содержание витаминов в плазме крови. Если недостаточность обнаружена, рекомендован прием витаминов (цианокобаламина и фолиевой кислоты) до начала лечения адеметионином или одновременный прием с адеметионином.\u003Cbr /\u003EПри иммунологическом анализе применение адеметионина может способствовать ложному определению показателя высокого содержания гомоцистеина в крови.\u003Cbr /\u003EДля пациентов, принимающих адеметионин, рекомендовано использовать неиммунологические методы анализа для определения содержания гомоцистеина."},{"name":"Взаимодействие","value":"Известных взаимодействий с другими лекарственными средствами не наблюдалось. Если Вы применяете нижеперечисленные или другие лекарственные препараты (в том числе безрецептурные) перед применением препарата проконсультируйтесь с врачом. Есть сообщение о синдроме избытка серотонина у пациента, принимавшего адеметионин и кломипрамин. Считается, что такое взаимодействие возможно, и следует с осторожностью применять адеметионин вместе с селективными ингибиторами обратного захвата серотонина, трициклическими антидепрессантами (такими как кломипрамин), а также лекарственными средствами, содержащими триптофан (в том числе, растительного происхождения)."},{"name":"Регистрационный номер","value":"ЛП-007320"},{"name":"Дата государственной регистрации","value":"24.08.2021"},{"name":"Владелец регистрационного удостоверения","value":"Велфарм"},{"name":"Изготовитель","value":"Велфарм"},{"name":"Фасовщик","value":"Велфарм"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Срок годности","value":"1 г."}]}],"transitionId":"tr_6"}}}}
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Цена с картой Яндекс Пэй:2 858 ₽

Скидка: 2%
–2 %
Вместо: 2 916 ₽
  • 29 мая, курьер Маркета • 0 ₽
POLZAru
Рейтинг 4.9 из 5
37Котзывов
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расстройства."},{"description":"","filters":[{"id":15768292,"name":"Состав"}],"isMainProperty":false,"name":"Состав","value":"Состав на одну таблетку:\u003Cbr /\u003EДействующее вещество: адеметионина 1,4-бутандисульфонат - 760,0 мг (в пересчете на адеметионин-ион - 400,0 мг).\u003Cbr /\u003EВспомогательные вещества: кремния диоксид коллоидный (аэросил), магния стеарат, карбоксиметилкрахмал натрия (натрия крахмал гликолят, примогель), целлюлоза микрокристаллическая (112).\u003Cbr /\u003EСостав оболочки: кишечнорастворимое пленочное покрытие (ACRYL-EZE 93А18597 белый), содержащее метакриловой кислоты и этилакрилата сополимер (1:1), тальк, титана диоксид, кремния диоксид коллоидный, натрия бикарбонат, натрия лаурилсульфат; триэтил цитрат."},{"description":"","filters":[{"id":27144131,"name":"Действующее вещество"}],"isMainProperty":false,"name":"Действующее вещество","value":"Адеметионин"},{"description":"","filters":[{"id":15768000,"name":"Способ применения и дозы"}],"isMainProperty":false,"name":"Способ применения и дозы","value":"Внутрь.\u003Cbr /\u003EТаблетки следует принимать целиком, не разжевывая, желательно в первой половине дня между приемами пищи.\u003Cbr /\u003EТаблетки адеметионина следует вынимать из упаковки непосредственно перед приемом внутрь. В случае если таблетки имеют цвет, отличный от белого до белого с желтоватым оттенком цвета (вследствие негерметичности упаковки), препарат применять не рекомендуется.\u003Cbr /\u003EРекомендуемая доза составляет 10-25 мг адеметионина на 1 кг массы тела в сутки.\u003Cbr /\u003EОбычно суточная доза составляет 1 -2 таблетки в сутки (от 400-800 мг адеметионина в сутки) и может быть увеличена до 4 таблеток в сутки (до 1600 мг адеметионина в сутки). Эффект обычно проявляется через 7-14 дней лечения и сохраняется при дальнейшем применении препарата.\u003Cbr /\u003EПри отсутствии положительного эффекта от проводимой в течение 2 недель терапии препаратом или ухудшении состояния следует обратиться к врачу.\u003Cbr /\u003EПациенты пожилого возраста\u003Cbr /\u003EКлинический опыт применения адеметионина не выявил каких-либо различий в его эффективности у пациентов пожилого возраста и пациентов более молодого возраста. Однако, учитывая высокую вероятность имеющихся нарушений функции печени, почек или сердца, другой сопутствующей патологии или одновременной терапии с другими лекарственными средствами, дозу препарата пожилым пациентам следует подбирать с осторожностью, начиная применение препарата с нижнего предела диапазона доз.\u003Cbr /\u003EПочечная недостаточность\u003Cbr /\u003EИмеются ограниченные клинические данные о применении адеметионина у пациентов с почечной недостаточностью, в связи с этим рекомендуется соблюдать осторожность при применении препарата у таких пациентов.\u003Cbr /\u003EПеченочная недостаточность\u003Cbr /\u003EПараметры фармакокинетики адеметионина сходны у здоровых добровольцев и у пациентов с хроническими заболеваниями печени.\u003Cbr /\u003EДети и подростки до 18 лет\u003Cbr /\u003EПрименение адеметионина у детей и подростков до 18 лет противопоказано (эффективность и безопасность не установлены)."},{"description":"","filters":[{"id":15767998,"name":"Побочные действия"}],"isMainProperty":false,"name":"Побочные действия","value":"Среди наиболее частых нежелательных реакций, исследований с участием примерно 2000 пациентов, были: головная боль, тошнота и диарея.\u003Cbr /\u003EНиже приведены данные о нежелательных реакциях, наблюдавшихся в ходе клинических исследований (n=1922) и в пострегистрационном периоде наблюдения («спонтанные» сообщения).\u003Cbr /\u003EНежелательные реакции распределены по системно-органным классам и частоте их возникновения: очень часто (\u003E1/10); часто (\u003E1/100, \u003C1/10); нечасто (\u003E1/1000, \u003C1/100); редко (\u003E1/10000, \u003C1/1000); очень редко (\u003C 1/10000).\u003Cbr /\u003EИнфекционные и паразитарные заболевания: нечасто - инфекции мочевыводящих путей.\u003Cbr /\u003EНарушения со стороны иммунной системы: нечасто - реакции гиперчувствительности, анафилактоидные или анафилактические реакции (в том числе покраснение кожных покровов, одышка, бронхоспазм, боль в спине, ощущение дискомфорта в области грудной клетки, изменение артериального давления (снижение артериального давления, повышение артериального давления) или частоты пульса (учащение, урежение)).\u003Cbr /\u003EНарушение психики: часто - тревога, бессонница; нечасто - ажитация (сильное эмоциональное возбуждение, сопровождающееся двигательным беспокойством), спутанность сознания.\u003Cbr /\u003EНарушения со стороны нервной системы: часто - головная боль; нечасто - головокружение, парестезия, дисгевзия (расстройства вкуса, характеризующиеся утратой вкуса или извращением вкусовых восприятий).\u003Cbr /\u003EНарушения со стороны сосудов: нечасто - «приливы», снижение артериального давления, флебит.\u003Cbr /\u003EНарушения со стороны дыхательной системы, органов грудной клетки и средостения: нечасто - отек гортани.\u003Cbr /\u003EНарушения со стороны желудочно-кишечного тракта: часто - боль в животе, диарея, тошнота; нечасто - сухость во рту, диспепсия, метеоризм, желудочно-кишечная боль, желудочно-кишечные расстройства, желудочно-кишечное кровотечение, рвота, эзофагит; редко - вздутие живота.\u003Cbr /\u003EНарушения со стороны кожи и подкожных тканей: часто - кожный зуд; нечасто - повышенное потоотделение, ангионевротический отек, кожно-аллергические реакции (в том числе сыпь, кожный зуд, крапивница, эритема).\u003Cbr /\u003EНарушения со стороны скелетно-мышечной и соединительной ткани: нечасто - артралгия, мышечные спазмы.\u003Cbr /\u003EОбщие расстройства и нарушения в месте введения: часто - астения; нечасто - отек, лихорадка, озноб; редко - недомогание.\u003Cbr /\u003EЕсли у Вас отмечаются нежелательные реакции, указанные в инструкции, или они усугубляются, или Вы заметили любые другие нежелательные реакции, не указанные в инструкции, сообщите об этом врачу."},{"description":"","filters":[{"id":15768001,"name":"Фармакологическое действие"}],"isMainProperty":false,"name":"Фармакологическое действие","value":"Адеметионин относится к группе гепатопротекторов. Оказывает желчегонное действие, обладает детоксикационными, регенерирующими, антиоксидантными, антифиброзирующими и нейропротективными свойствами.\nАдеметионин (S-аденозил-L-метионин) - это аминокислота естественного происхождения, которая присутствует практически во всех тканях и биологических жидкостях в организме. Наибольшая концентрация адеметионина отмечена в печени и мозге. Адеметионин является производным серосодержащей аминокислоты-метионина. Выполняет ключевую роль в метаболических процессах организма, принимает участие в важных биохимических реакциях. Участвует в синтезе фосфолипидов клеточных мембран, нейротрансмиттеров, нуклеиновых кислот, белков, гормонов и др. Адеметионин является предшественником цистеина, таурина, глутатиона (обеспечивая окислительно-восстановительный механизм клеточной детоксикации), коэнзима А (включается в биохимические реакции цикла трикарбоновых кислот и восполняет энергетический потенциал клетки). Повышает содержание глутамина в печени, цистеина и таурина в плазме; снижает содержание метионина в сыворотке, нормализуя метаболические реакции в печени. Опосредованно участвует в стимуляции регенерации и пролиферации клеток печени, что уменьшает риск фиброзирования. Адеметионин нормализует синтез эндогенного фосфатидилхолина в гепатоцитах, что повышает текучесть и поляризацию мембран. Это улучшает функцию ассоциированных с мембранами гепатоцитов транспортных систем желчных кислот и способствует пассажу желчных кислот в желчевыводящие пути. Эффективен при внутридольковом варианте холестаза (нарушение синтеза и тока желчи). Адеметионин снижает токсичность желчных кислот в клетках печени. У пациентов с диффузными заболеваниями печени (цирроз, гепатит) адеметионин снижает выраженность кожного зуда и способствует улучшению биохимических показателей крови, в т.ч. концентрации прямого билирубина, активности щелочной фосфатазы, аминотрансфераз и др. Желчегонный и гепатопротекторный эффект сохраняется до 3 месяцев после прекращения лечения. Показана эффективность при гепатопатиях, обусловленных различными гепатотоксичными препаратами. В ряде исследований была подтверждена эффективность адеметионина при лечении повышенной утомляемости у пациентов с хроническими заболеваниями печени."},{"description":"","filters":[{"id":34045110,"name":"Фармакологическая группа"}],"isMainProperty":false,"name":"Фармакологическая группа","value":"прочие препараты для желудочно-кишечного тракта и обмена веществ, аминокислоты и их производные"},{"description":"","filters":[{"id":27141511,"name":"Форма выпуска для карточки"}],"isMainProperty":false,"name":"Форма выпуска","value":"таблетки, покрытые кишечнорастворимой оболочкой"},{"description":"","filters":[{"id":35947170,"name":"Способ применения/введения"}],"isMainProperty":false,"name":"Способ применения/введения","value":"пероральный"},{"description":"","filters":[{"id":23679511,"name":"Минимальный возраст применения"},{"id":16082123,"name":"С рождения"}],"isMainProperty":false,"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","specs":[{"description":"","filters":[{"id":15767999,"name":"Условия хранения"}],"isMainProperty":false,"name":"Условия хранения","value":"При температуре не выше 25 °С. Хранить в местах, недоступных для детей."},{"description":"","filters":[{"id":15768014,"name":"Передозировка"}],"isMainProperty":false,"name":"Передозировка","value":"Передозировка препаратом маловероятна. В случае передозировки следует немедленно обратиться к врачу. Лечение: симптоматическое."},{"description":"","filters":[{"id":15768015,"name":"Применение при беременности и кормлении грудью"}],"isMainProperty":false,"name":"Применение при беременности и кормлении грудью","value":"Применение препарата при беременности и в период грудного вскармливания не рекомендуется без наблюдения у врача."},{"description":"","filters":[{"id":17360993,"name":"Влияние на способность управлять транспортом и механизмами"}],"isMainProperty":false,"name":"Влияние на способность управлять транспортом и механизмами","value":"При приеме адеметионина возможны головокружение и снижение артериального давления. В случае появления данных нежелательных реакций следует воздержаться от управления транспортными средствами и механизмами до их исчезновения."},{"description":"","filters":[{"id":15771167,"name":"Особые указания"}],"isMainProperty":false,"name":"Особые указания","value":"С осторожностью:\u003Cbr /\u003EОдновременный прием с селективными ингибиторами обратного захвата серотонина (СИОЗС), трициклическими антидепрессантами (такими как кломипрамин), а также лекарственными средствами, содержащими триптофан, в том числе, растительного происхождения (см. раздел «Взаимодействие с другими лекарственными средствами»).\u003Cbr /\u003EПожилой возраст.\u003Cbr /\u003EПочечная недостаточность.\u003Cbr /\u003EНеобходимо обратиться к врачу при отсутствии улучшения или ухудшения состояния. Учитывая тонизирующий эффект препарата, не рекомендуется принимать его перед сном. При применении препарата пациентам с циррозом печени на фоне гиперазотемии необходим систематический контроль содержания азота в крови. Во время длительной терапии необходимо определять концентрацию мочевины и креатинина в плазме крови. Пациентам с депрессией или получающих антидепрессанты следует обратиться к врачу перед началом приема препарата. Имеются сообщения о внезапном появлении или нарастании тревоги у пациентов, принимающих адеметионин. В большинстве случаев прекращения приема препарата не требуется, в нескольких случаях тревога исчезала после снижения дозы или отмены препарата.\u003Cbr /\u003EПоскольку дефицит цианокобаламина (витамина В12) и фолиевой кислоты может снизить содержание адеметионина у пациентов группы риска (с анемией, заболеваниями печени, при беременности или вероятностью витаминной недостаточности, в связи с другими заболеваниями или диетой, например, у вегетарианцев), следует контролировать содержание витаминов в плазме крови. Если недостаточность обнаружена, рекомендован прием витаминов (цианокобаламина и фолиевой кислоты) до начала лечения адеметионином или одновременный прием с адеметионином.\u003Cbr /\u003EПри иммунологическом анализе применение адеметионина может способствовать ложному определению показателя высокого содержания гомоцистеина в крови.\u003Cbr /\u003EДля пациентов, принимающих адеметионин, рекомендовано использовать неиммунологические методы анализа для определения содержания гомоцистеина."},{"description":"","filters":[{"id":15768012,"name":"Взаимодействие"}],"isMainProperty":false,"name":"Взаимодействие","value":"Известных взаимодействий с другими лекарственными средствами не наблюдалось. Если Вы применяете нижеперечисленные или другие лекарственные препараты (в том числе безрецептурные) перед применением препарата проконсультируйтесь с врачом. Есть сообщение о синдроме избытка серотонина у пациента, принимавшего адеметионин и кломипрамин. Считается, что такое взаимодействие возможно, и следует с осторожностью применять адеметионин вместе с селективными ингибиторами обратного захвата серотонина, трициклическими антидепрессантами (такими как кломипрамин), а также лекарственными средствами, содержащими триптофан (в том числе, растительного происхождения)."},{"description":"","filters":[{"id":16435314,"name":"Регистрационный номер"}],"isMainProperty":false,"name":"Регистрационный номер","value":"ЛП-007320"},{"description":"","filters":[{"id":16435315,"name":"Дата государственной регистрации"}],"isMainProperty":false,"name":"Дата государственной регистрации","value":"24.08.2021"},{"description":"","filters":[{"id":34324371,"name":"Тип препарата"},{"id":7893318,"name":"Производитель"}],"isMainProperty":false,"name":"Владелец регистрационного 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Инструкция

Показания к применению

- вспомогательная терапия при установленных хронических заболеваниях печени, для улучшения и поддержания ее функций;
- повышенная утомляемость при установленных хронических заболеваниях печени.

Противопоказания

- генетические нарушения, влияющие на метиониновый цикл и/или вызывающие гомоцистинурию и/или гипергомоцистеинемию (дефицит цистатионин бетасинтазы, нарушение метаболизма витамина В12).
- повышенная чувствительность к любому из компонентов препарата;
- возраст до 18 лет (в связи с отсутствием данных по эффективности и безопасности применения адеметионина в данной возрастной популяции);
- биполярные расстройства.

Способ применения и дозы

Внутрь.
Таблетки следует принимать целиком, не разжевывая, желательно в первой половине дня между приемами пищи.
Таблетки адеметионина следует вынимать из упаковки непосредственно перед приемом внутрь. В случае если таблетки имеют цвет, отличный от белого до белого с желтоватым оттенком цвета (вследствие негерметичности упаковки), препарат применять не рекомендуется.
Рекомендуемая доза составляет 10-25 мг адеметионина на 1 кг массы тела в сутки.
Обычно суточная доза составляет 1 -2 таблетки в сутки (от 400-800 мг адеметионина в сутки) и может быть увеличена до 4 таблеток в сутки (до 1600 мг адеметионина в сутки). Эффект обычно проявляется через 7-14 дней лечения и сохраняется при дальнейшем применении препарата.
При отсутствии положительного эффекта от проводимой в течение 2 недель терапии препаратом или ухудшении состояния следует обратиться к врачу.
Пациенты пожилого возраста
Клинический опыт применения адеметионина не выявил каких-либо различий в его эффективности у пациентов пожилого возраста и пациентов более молодого возраста. Однако, учитывая высокую вероятность имеющихся нарушений функции печени, почек или сердца, другой сопутствующей патологии или одновременной терапии с другими лекарственными средствами, дозу препарата пожилым пациентам следует подбирать с осторожностью, начиная применение препарата с нижнего предела диапазона доз.
Почечная недостаточность
Имеются ограниченные клинические данные о применении адеметионина у пациентов с почечной недостаточностью, в связи с этим рекомендуется соблюдать осторожность при применении препарата у таких пациентов.
Печеночная недостаточность
Параметры фармакокинетики адеметионина сходны у здоровых добровольцев и у пациентов с хроническими заболеваниями печени.
Дети и подростки до 18 лет
Применение адеметионина у детей и подростков до 18 лет противопоказано (эффективность и безопасность не установлены).
Полная инструкция
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Адеметионин таб. кш/раств.
Адеметионин таб. кш/раств., 400 мг, 40 шт.
4.9
(34)
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3 вопроса
Инструкция

Цена с картой Яндекс Пэй:2 858 ₽

Скидка: 2%
–2 %
Вместо: 2 916 ₽
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4.9
У этого продавца: 34 оценки
•
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У всех продавцов: 57 оценок
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user avatar
23 марта • Алексей Мокров
Достоинства: Уже съелНедостатки: Нет
user avatar
3 марта • Данил Фазуллин
Достоинства: хорошо пргладывать, цена, аналог гептралаНедостатки: нетКомментарий: пока еще рано что то говорить, только начал курс
user avatar
10 ноября 2023 • Евгения
Достоинства: принимаем по рецепту, всё нравитсяНедостатки: нетКомментарий: всё согласно инструкции
user avatar
10 ноября 2023 • Имя скрыто
Комментарий: Очень помогла
user avatar
9 ноября 2023 • Алексей. С
Достоинства: Помагает если ваша печень не совсем умерлаНедостатки: Цена, хотелось бы подешевлиКомментарий: После обильного возлияния, или если вы любите соленое, острое, жирное, надо иногда давать печени отдых, и подлечить ее.
user avatar
4 ноября 2023 • Сергей Девин.
Достоинства: без рецепта. полезно для поддержания и восстановления здоровья печени.Недостатки: не обнаружил.Комментарий: прописала врач инфекцианист.
user avatar
3 ноября 2023 • Татьяна Баринова
Достоинства: Обновляет печень,поддерживает.Недостатки: Нет,замечательное лекарствоКомментарий: Рекомендую к покупке
user avatar
2 ноября 2023 • Дмитрий
Достоинства: Хорошее лекарство для печени. Мало побочекНедостатки: НетКомментарий: Пропил курс даже желтушность пропала с лица. Сил стало больше. Пропиваю раз в год. Помогает
user avatar
11 октября 2023 • Хусниддин Б.
Достоинства: отлично
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  • Гептрал таб. п/о кш/раств., 400 мг, 20 шт.
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    Гептрал таб. п/о кш/раств., 400 мг, 20 шт.

    Цена 1 914 ₽ вместо 2 422
  • Таблетница из 14 секций на семь дней Утро-вечер
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    Таблетница из 14 секций на семь дней Утро-вечер

    Цена 167 ₽ вместо 200
  • Гептор таб. п/о кш/раств., 400 мг, 20 шт.
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    Гептор таб. п/о кш/раств., 400 мг, 20 шт.

    Цена 1 234 ₽
  • Таблетница - брелок на день, 1 раздел, контейнер для таблеток металлический маленький (черный матовый)
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    Таблетница - брелок на день, 1 раздел, контейнер для таблеток металлический маленький (черный матовый)

    Цена 235 ₽ вместо 599
  • Гепатрин капс., 120 шт.
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    Гепатрин капс., 120 шт.

    Цена 895 ₽ вместо 1 000
  • Самеликс таб. п/о плен. кш/раств., 400 мг, 20 шт.
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    Самеликс таб. п/о плен. кш/раств., 400 мг, 20 шт.

    Цена 1 315 ₽
  • Таблетница на 7 дней/контейнер для таблеток и витаминов на 7 дней, Immunit
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    Таблетница на 7 дней/контейнер для таблеток и витаминов на 7 дней, Immunit

    Цена 171 ₽ вместо 189
  • Гептрал таб. п/о кш/раств., 500 мг, 20 шт.
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    Гептрал таб. п/о кш/раств., 500 мг, 20 шт.

    Цена 2 433 ₽
  • Реклама
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    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  • Эссенциале форте Н капс., 300 мг, 30 шт.
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    Эссенциале форте Н капс., 300 мг, 30 шт.

    Цена 740 ₽ вместо 747
  • Гептрал лиоф. д/приг. р-ра для в/в и в/м введ. фл. р-ль амп., 400 мг, 5 шт.
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    Гептрал лиоф. д/приг. р-ра для в/в и в/м введ. фл. р-ль амп., 400 мг, 5 шт.

    Цена 1 932 ₽ вместо 2 145
  • Таблетница на день мини для капсул контейнер для таблеток белый
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    Таблетница на день мини для капсул контейнер для таблеток белый

    Цена 282 ₽ вместо 750
  • Таблетница на 7 дней / органайзер / бокс / контейнер на неделю для хранения таблеток и лекарств 4 приема Clear Daswerk
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    Таблетница на 7 дней / органайзер / бокс / контейнер на неделю для хранения таблеток и лекарств 4 приема Clear Daswerk

    Цена 439 ₽ вместо 637
  • Таблетница органайзер на неделю утро / день / вечер; Органайзер для таблеток на 7 дней; Карманная аптечка
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    Таблетница органайзер на неделю утро / день / вечер; Органайзер для таблеток на 7 дней; Карманная аптечка

    Цена 781 ₽ вместо 1 890
  • Гептрал лиоф. для приг. р-ра для в/в и в/м введ. фл., 400 мг, 5 шт.
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    Гептрал лиоф. для приг. р-ра для в/в и в/м введ. фл., 400 мг, 5 шт.

    Цена 1 956 ₽ вместо 2 475
  • Фосфоглив капс., 50 шт.
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    Фосфоглив капс., 50 шт.

    Цена 645 ₽ вместо 816
  • Таблетница Органайзер на 7 дней с делениями x1
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    Таблетница Органайзер на 7 дней с делениями x1

    Цена 180 ₽ вместо 184
  • Капсулы желатиновые пустые раскрытые белые Размер 0# 500шт
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    Капсулы желатиновые пустые раскрытые белые Размер 0# 500шт

    Цена 569 ₽ вместо 1 250
  • Таблетница с зеркальной поверхностью, 3 секции, d = 5см, цвет серебристый
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    Таблетница с зеркальной поверхностью, 3 секции, d = 5см, цвет серебристый

    Цена 290 ₽ вместо 419
  • Таблетница "Неделька" , английские буквы , 7 секций , цвет прозрачный
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    Таблетница "Неделька" , английские буквы , 7 секций , цвет прозрачный

    Цена 382 ₽ вместо 497
  • Таблетница компактная /органайзер аптечка/ контейнер для таблеток БАД Panda_Home (синего цвета)
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1697098837_20/content/content/gallery":{"title":"Таблетница компактная /органайзер аптечка/ контейнер для таблеток БАД Panda_Home (синего цвета)","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/5232043/img_id7017230458924859337.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5232043/img_id7017230458924859337.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5232043/img_id7017230458924859337.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5232043/img_id7017230458924859337.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5232043/img_id7017230458924859337.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5232043/img_id7017230458924859337.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 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    Таблетница компактная /органайзер аптечка/ контейнер для таблеток БАД Panda_Home (синего цвета)

    Цена 235 ₽ вместо 380
  • Реклама
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  • Контейнер для хранения/таблетница/кейс для таблеток
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    Контейнер для хранения/таблетница/кейс для таблеток

    Цена 246 ₽ вместо 699
  • Таблетница пилюля С делителем
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    Таблетница пилюля С делителем

    Цена 461 ₽ вместо 665
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