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Описание

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Азитромицин капс., 500 мг, 3 шт.

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4.7
(156)
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Дозировка: 500 мг

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Количество штук в упаковке, шт.: 3

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Коротко о товаре

Артикул Маркета
34572414
Тип препарата
Назначение
бактериальные инфекции верхних отделов дыхательных путей и ЛОР-органов, бактериальные инфекции кожи и мягких тканей, бактериальные инфекции нижних отделов дыхательных путей, болезнь Лайма, бронхит, вторично инфицированные дерматозы, импетиго, инфекции мочеполовых путей (уретрит и/или цервицит), вызванные Chlamydia trachomatis, инфекционно-воспалительные заболевания, мигрирующая эритема, острые хронические и рецидивирующие инфекции мочеполовой системы, пневмония, рожистое воспаление, синусит, средний отит, тонзиллит, угревая болезнь, фарингит
Действующее вещество
Возраст
от 12 лет
Инструкция
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инфицированные дерматозы;\u003Cbr\u003E- начальная стадия болезни Лайма (боррелиоз) - мигрирующая эритема (erythema migrans);\u003Cbr\u003E- инфекции мочеполовых путей, вызванные Chlamydia trachomatis (уретрит, цервицит)."},{"name":"Противопоказания","value":"- Повышенная чувствительность к азитромицину, эритромицину, другим антибиотикам группы макролидов или кетолидов, или к другим компонентам препарата;\u003Cbr\u003E- тяжелая печеночная недостаточность класс С по Чайлд-Пью);\u003Cbr\u003E- детский возраст до 12 лет с массой тела менее 45 кг;\u003Cbr\u003E- одновременный прием с эрготамином и дигидроэрготамином."},{"name":"Состав","value":"На одну капсулу:\u003Cbr\u003EДействующее вещество:\u003Cbr\u003EАзитромицина дигидрата (в пересчете на азитромицин) 500 мг или 250 мг\u003Cbr\u003EВспомогательные вещества:\u003Cbr\u003EЦеллюлоза микрокристаллическая - 40,20 мг или 109,0 мг\u003Cbr\u003EМагния стеарат - 5,70 мг или 3,75 мг\u003Cbr\u003EМасса содержимого капсулы: 570 мг или 375 мг\u003Cbr\u003EСостав оболочки капсулы № 00:\u003Cbr\u003EКорпус: диоксид титана 2,00%, желатин до 100%\u003Cbr\u003EКрышечка: диоксид титана 1,74%, закатный желтый FCF-FD&C 0,41%, желатин до 100%.\u003Cbr\u003EСостав оболочки капсулы № 0:\u003Cbr\u003EКорпус: диоксид титана 2,00%, желатин до 100%\u003Cbr\u003EКрышечка: диоксид титана 1,74%, закатный желтый FCF-FD&C 0,41%, желатин до 100%.\u003Cbr\u003E"},{"name":"Действующее вещество","value":"Азитромицин","transition":{"type":"catalog","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["27144131:28710006"]}}},{"name":"Способ применения и дозы","value":"Внутрь, 1 раз в сутки по 500 мг, по крайней мере, за 1 час до или через 2 часа после приема пищи.\u003Cbr\u003EВзрослым (включая пожилых людей) и детям старше 12 лет с массой тела свыше 45 кг\u003Cbr\u003EПри инфекциях верхних и нижних дыхательных путей, лор-органов, кожи и мягких тканей: по 500 мг 1 раз в сутки в течение 3-х дней (курсовая доза - 1,5 г).\u003Cbr\u003EПри угрях обыкновенных средней степени тяжести: по 2 капсулы 250 мг 1 раз в сутки в течение 3-х дней, затем по 250 мг 2 раза в неделю в течение 9 дней. Курсовая доза 6,0 г.\u003Cbr\u003EПри болезни Лайма (боррелиоз) - мигрирующей эритеме: в первый день одновременно 2 капсулы по 500 мг, затем со 2-го по 5-й день по 500 мг ежедневно. Курсовая доза 3,0 г.\u003Cbr\u003EПри инфекциях мочеполовых путей, вызванных Chlamydia trachomatis (уретрит, цервицит): неосложненный уретрит/цервицит - одновременно 2 капсулы по 500 мг однократно.\u003Cbr\u003EПри нарушении функции почек: у пациентов с СКФ 10-80 мл/мин коррекции дозы не требуется.\u003Cbr\u003EПри нарушении функции печени: при применении у пациентов с нарушением функции печени легкой и средней степени тяжести коррекции дозы не требуется.\u003Cbr\u003EПожилые пациенты: коррекция дозы не требуется, поскольку пожилые пациенты уже могут иметь текущие проаритмогенные состояния, следует соблюдать осторожность при применении азитромицина, в связи с высоким риском развития сердечных аритмий, в том числе аритмии типа \"пируэт\"."},{"name":"Побочные действия","value":"В соответствии с рекомендациями ВОЗ частота побочных эффектов классифицируется: очень часто - не менее 10%;. часто - не менее 1%, но менее 10%; нечасто - не менее 0,1%, но менее 1%; очень редко - менее 0,01%, неизвестная частота - не может быть оценена, исходя из имеющихся данных.\u003Cbr\u003EСо стороны желудочно-кишечного тракта: очень часто - диарея; часто - тошнота, рвота, боли в животе, жидкий стул, гастрит, дисфагия, повышение секреции слюнных желез; нечасто - метеоризм, расстройство пищеварения, анорексия, вздутие живота, запор, сухость слизистой оболочки полости рта, отрыжка, язвы слизистой оболочки полости рта; очень редко - изменение цвета языка, панкреатит.\u003Cbr\u003EСо стороны обмена веществ и питания: нечасто - анорексия.\u003Cbr\u003EАллергические реакции: нечасто - ангионевротический отек реакция гиперчувствительности; неизвестная частота - анафилактическая реакция (в редких случаях со смертельным исходом).\u003Cbr\u003EСо стороны сердечно-сосудистой системы: нечасто - ощущение сердцебиения, \"приливы\" крови к лицу; неизвестная частота - аритмия типа \"пируэт\", понижение артериального давления желудочковая тахикардия, увеличение интервала QT, двунаправленная желудочковая тахикардия.\u003Cbr\u003EСо стороны нервной системы: часто - головная боль; нечасто - головокружение/вертиго, сонливость, парастезия, нервозность, бессонница, нарушение вкусовых ощущений; редко - ажитация; неизвестная частота - гиперактивность, агрессивность, беспокойство, судороги, обморок, гипестезия, потеря или извращение обоняния, бред, галлюцинации, миастения.\u003Cbr\u003EСо стороны органов чувств: нечасто - шум в ушах, вертиго, нарушение зрения; неизвестная частота - обратимое нарушение слуха вплоть до глухоты (при приеме высоких доз в течение длительного времени).\u003Cbr\u003EСо стороны дыхательной системы: нечасто - одышка, носовое кровотечение.\u003Cbr\u003EСо стороны кровеносной и лимфатической систем: нечасто - нейтропения, эозинофилия, лейкопения; очень редко - тромбоцитопения, гемолитическая анемия.\u003Cbr\u003EСо стороны опорно-двигательного аппарата: нечасто - остеоартрит, миалгия, боль в шее, боль в спине; неизвестная частота - артралгия.\u003Cbr\u003EСо стороны мочеполовой системы: нечасто - дизурия, боль в области почек; неизвестная частота - интерстициальный нефрит, острая почечная недостаточность.\u003Cbr\u003EСо стороны половых органов и молочной железы: нечасто - метроррагии, нарушение функции яичек.\u003Cbr\u003EСо стороны печени и желчевыводящих путей: нечасто - гепатит; редко - изменение лабораторных показателей функции печени, холестатическая желтуха; неизвестная частота - печеночная недостаточность, некроз печени (возможно со смертельным исходом), фульминантный гепатит.\u003Cbr\u003EСо стороны кожи и подкожных тканей: зуд, кожные высыпания, крапивница, дерматит, потливость, сухость кожи; редко - фотосенсибилизация; неизвестная частота - мультиформная эритема, синдром Стивенса-Джонсона, токсический эпидермальный некролиз.\u003Cbr\u003EИнфекционные заболевания: нечасто - кандидоз, в том числе слизистой оболочки полости рта и гениталий, пневмония, фарингит, гастроэнтерит, респираторные заболевания, ринит; неизвестная частота - псевдомембранозный колит.\u003Cbr\u003EПрочие: нечасто - астения, ощущение усталости, недомогание, отеки лица, периферические отеки, лихорадка, боль в груди.\u003Cbr\u003EЛабораторные данные: часто - снижение количества лимфоцитов, повышение количества эозинофилов, повышение количества базофилов, повышение количества моноцитов, повышение количества нейтрофилов, снижение концентрации бикарбонатов в плазме крови; нечасто - повышение активности аспартатаминострансферазы, аланинаминострансферазы, повышение концентрации билирубина в плазме крови, повышение концентрации мочевины в плазме крови, повышение концентрации креатинина в плазме крови, изменение содержания калия в плазме крови, повышение активности щелочной фосфатазы, повышение содержания хлора в плазме крови, увеличение количества тромбоцитов, повышение концентрации бикарбонатов в плазме крови, изменение содержания натрия в плазме крови."},{"name":"Фармакологическое действие","value":"Антибактериальный препарат широкого спектра действия из группы макролидов-азалидов, действует бактериостатически.\u003Cbr\u003EСвязываясь с 50S субъединицей рибосом, угнетает пептидтранслоказу на стадии трансляции, подавляет синтез белка, замедляет рост и размножение бактерий, в высоких концентрациях оказывает бактерицидный эффект. Действует на вне- и внутриклеточно расположенных возбудителей.\u003Cbr\u003EОбладает активностью в отношении ряда грамположительных, грамотрицательных, анаэробов, внутриклеточных и других микроорганизмов.\u003Cbr\u003EМикроорганизмы могут быть изначально устойчивыми к действию антибиотика или могут приобретать устойчивость к нему.\u003Cbr\u003EЧувствительны:\u003Cbr\u003Eаэробные грамположительные микроорганизмы: Staphylococcus aureus (метилциллинчувствительные), Streptococcus pneumoniae (пенициллинчувствительные), Streptococcus pyogenes;\u003Cbr\u003Eаэробные грамотрицательные микроорганизмы: Haemophilus influenzae, Haemophilus parainfluenzae, Legionella pneumophila, Moraxella catarrhalis, Pasteurella multocida, Neisseria gonorrhoeae;\u003Cbr\u003Eанаэробные микроорганизмы: Clostridium perfringens, Fusobacterium spp., Prevotella spp., Porphyromonas spp.;\u003Cbr\u003E\u003Cbr\u003Eпрочие: Chlamydia trachomatis, Chlamydia pneumoniae, Chlamydia psittaci, Mycoplasma pneumoniae, Mycoplasma hominis, Borrelia burgdoferi.\u003Cbr\u003E\u003Cbr\u003EУмеренно чувствительны или нечувствительны:\u003Cbr\u003Eаэробные грамположительные микроорганизмы: Streptococcus pneumoniae (умеренно чувствительные или резистентные к пенициллину).\u003Cbr\u003EУстойчивы:\u003Cbr\u003Eаэробные грамположительные микроорганизмы: Enterococcus faecalis, Staphylococci spp. (метициллинустойчивые), Staphylococus aureus (включая метициллинчувствительные штаммы), Staphylococus pneumoniae, Staphylococcus spp. группы А (бета-гемолитические).\u003Cbr\u003EАзитромицин не активен в отношении штаммов грамположительных бактерий, устойчивых к эритромицину.\u003Cbr\u003EАнаэробы:\u003Cbr\u003EГруппа Bacteroides fragilis."},{"name":"Фармакологическая группа","value":"антибиотик-макролид"},{"name":"Форма выпуска","value":"капсулы"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 12 лет"},{"name":"Условия хранения","value":"В сухом, защищенном от света месте, при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы: временная потеря слуха, тошнота, рвота, диарея.\u003Cbr\u003EЛечение: симптоматическое."},{"name":"Применение при беременности и кормлении грудью","value":"Азитромицин при беременности и в период грудного вскармливания рекомендуется применять только в случаях, когда ожидаемая польза от его приема для матери превышает потенциальный риск для плода и ребенка.\u003Cbr\u003EПри необходимости применения препарата в период грудного вскармливания рекомендуется приостановить грудное вскармливание."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения препаратом следует соблюдать осторожность при управлении транспортными средствами и занятиями другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций в связи с возможностью развития нежелательных эффектов со стороны нервной системы и органа зрения."},{"name":"Особые указания","value":"В случае пропуска приема антибиотика, пропущенную дозу следует принять как можно раньше, а последующие дозы принимать с интервалом в 24 ч.\u003Cbr\u003EПрепарат следует принимать, по крайней мере, за 1 час до или через 2 часа после приема антацидных препаратов.\u003Cbr\u003EПри наличии симптомов нарушения функции печени, такие как астения, желтуха, потемнение мочи, склонность к кровотечениям, печеночная энцефалопатия терапию азитромицином следует прекратить и провести исследование функционального состояния печени.\u003Cbr\u003EПри нарушениях функции почек: у пациентов с СКФ 10-80 мл/мин коррекция дозы не требуется, терапию препаратом следует проводить с осторожностью под контролем состояния функции почек.\u003Cbr\u003EАзитромицин не следует применять более длительными курсами, чем указано в инструкции, так как фармакокинетические свойства препарата позволяют рекомендовать более короткий и простой режим дозирования.\u003Cbr\u003EКак и при применении других антибактериальных препаратов, при терапии азитромицином следует регулярно обследовать пациентов на наличие невосприимчивых микроорганизмов и признаки развития суперинфекций, в том числе грибковых.\u003Cbr\u003EПрименение препарата может спровоцировать развитие миастенического синдрома или вызвать обострение миастении.\u003Cbr\u003EПри длительном приеме азитромицина возможно развитие псевдомембранозного колита, вызванного Clostridium difficile, как в виде легкой диареи, так и тяжелого колита. При развитии антибиотик-ассоциированной диареи на фоне приема препарата, а также через 2 месяца после окончания терапии следует исключить клостридиальный псевдомембранозный колит. Нельзя применять препараты, тормозящие перистальтику кишечника.\u003Cbr\u003EПосле отмены терапии азитромицином реакции гиперчувствительности у некоторых пациентов могут сохраняться в течение продолжительного времени и могут потребовать специфической терапии под наблюдением врача.\u003Cbr\u003EПри лечении макролидами, в том числе, азитромицином, наблюдалось удлинение сердечной реполяризации и интервала QT, повышающих риск развития сердечных аритмий, в том числе аритмии типа \"пируэт\".\u003Cbr\u003EСледует соблюдать осторожность при применении препарата Азитромицин у пациентов с наличием проаритмогенных факторов (особенно у пожилых пациентов): с врожденным или приобретенным удлинением интервала QT, у пациентов, получающих терапию антиаритмическими препаратами классов IA (хинидин, прокаинамид), III (дофетилид, амиодарон, соталол), цизапридом, терфенадином, антипсихотическими препаратами (пимозид), антидепрессантами (циталопрам), фторхинолонами (моксифлоксацин и левофлоксацин), с нарушением водно-электролитного баланса, особенно в случае гипокалиемии или гипомагниемии, с клинически значимой брадикардией, аритмией сердца, или тяжелой сердечной недостаточностью.\u003Cbr\u003EС осторожностью:\u003Cbr\u003E- Миастения;\u003Cbr\u003E- нарушения функции печени легкой и средней степени тяжести;\u003Cbr\u003E- терминальная почечная недостаточность с СКФ (скорость клубочковой фильтрации) менее 10 мл/мин;\u003Cbr\u003E- у пациентов с наличием проаритмогенных факторов (особенно у пожилых пациентов): с врожденным или приобретенным удлинением интервала QT, у пациентов, получающих терапию антиаритмическими препаратами классов IA (хинидин, прокаинамид), III (дофетилид, амиодарон и соталол), цизапридом, терфенадином, антипсихотическими препаратами (пимозид), антидепрессантами (циталопрам), фторхинолонами (моксифлоксацин и левофлоксацин), с нарушениями водно-электролитного баланса, особенно в случае гипокалиемии или гипомагниемии, с клинически значимой брадикардией, аритмией сердца или тяжелой сердечной недостаточностью;\u003Cbr\u003E- при совместном применении циклоспорина, варфарина, дигоксина."},{"name":"Взаимодействие","value":"Антацидные препараты\u003Cbr\u003EАнтацидные препараты не влияют на биодоступность азитромицина, но уменьшают максимальную концентрацию в крови на 30%, поэтому препарат следует принимать, по крайней мере, за один час до или через два часа после приема этих препаратов и еды.\u003Cbr\u003EЦетиризин\u003Cbr\u003EОдновременное применение в течение 5 дней у здоровых добровольцев азитромицина с цетиризином (20 мг) не привело к фармакокинетическому взаимодействию и существенному изменению интервала QT.\u003Cbr\u003EДиданозин (дидезоксиинозин)\u003Cbr\u003EОдновременное применение азитромицина (1200 мг/сут) и диданозина (400 мг/сут) у 6 ВИЧ-инфицированных пациентов не выявило изменений фармакокинетических показаний диданозина по сравнению с группой плацебо.\u003Cbr\u003EДигоксин (субстраты Р-гликопротеина)\u003Cbr\u003EОдновременное применение макролидных антибиотиков, в том числе азитромицина, с субстратами Р-гликопротеина, такими как дигоксин, приводит к повышению концентрации субстрата Р-гликопротеина в сыворотке крови. Таким образом, при одновременном применении азитромицина и дигоксина необходимо учитывать возможность повышения концентрации дигоксина в сыворотке крови.\u003Cbr\u003EЗидовудин\u003Cbr\u003EОдновременное применение азитромицина (одноразовый прием 1000 мг и многократный прием 1200 мг или 600 мг) оказывает незначительное влияние на фармакокинетику, в том числе выведение почками зидовудина или его глюкуронидного метаболита. Однако применение азитромицина вызывало увеличение концентрации фосфорилированного задовудина, клинически активного метаболита в мононуклеарах периферической крови. Клиническое значение этого факта неясно.\u003Cbr\u003EАзитромицин слабо взаимодействует с изоферментами системы цитохрома Р450. Не выявлено, что азитромицин участвует в фармакокинетических взаимодействиях аналогичных эритромицину и другим макролидам. Азитромицин не является ингибитором и индуктором изоферментов цитохрома Р450.\u003Cbr\u003EАлкалоиды спорыньи\u003Cbr\u003EУчитывая теоретическую возможность возникновения эрготизма, одновременное применение азитромицина с производными алколоидов спорыньи не рекомендуется.\u003Cbr\u003EБыли проведены фармакокинетические исследования одновременного применения азитромицина и препаратов, метаболизм которых происходит с участием изоферментов системы цитохрома Р450.\u003Cbr\u003EАторвастатин\u003Cbr\u003EОдновременное применение аторвастатина (10 мг ежедневно) и азитромицина (500 мг ежедневно) не вызывало изменения концентраций аторвастатина в плазме крови (на основе анализа ингибирования ГМК-КоА-редуктазы). Однако в пострегистрационном периоде были получены отдельные сообщения о случаях рабдомиолиза у пациентов, получающих одновременно азитромицин и статины.\u003Cbr\u003EКарбамазепин\u003Cbr\u003EВ фармакокинетических исследованиях с участием здоровых добровольцев не выявлено существенного влияния на концентрацию карбамазепина и его активного метаболита в плазме крови у пациентов, получавших одновременно азитромицин.\u003Cbr\u003EЦиметидин\u003Cbr\u003EВ фармакокинетических исследованиях влияния разовой дозы циметидина на фармакокинетику азитромицина не выявлено изменений фармакокинетики азитромицина, при условии применения циметидина за 2 часа до азитромицина.\u003Cbr\u003EАнтикоагулянты непрямого действия (производные кумарина)\u003Cbr\u003EВ фармакокинетических исследованиях азитромицин не влиял на антикоагулянтный эффект однократной дозы 15 мг варфарина, принимаемого здоровыми добровольцами. Сообщалось о потенцировании антикоагулянтного эффекта после одновременного применения азитромицина и антикоагулянтов непрямого действия (производные кумарина). Несмотря на то, что причинная связь не установлена, следует учитывать необходимость проведения частого мониторинга протромбинового времени при применении азитромицина у пациентов, которые получают пероральные антикоагулянты непрямого действия (производные кумарина).\u003Cbr\u003EЦиклоспорин\u003Cbr\u003EВ фармакокинетическом исследовании с участием здоровых добровольцев, которые в течение 3 дней принимали внутрь азитромицин (500 мг/сут однократно), а затем циклоспорин (10 мг/кг/сут однократно), было выявлено достоверное повышение максимальной концентрации в плазме крови (Сmах) и площади под кривой \"концентрация-время\" (AUC0-5) циклоспорина. Следует соблюдать осторожность при одновременном применении этих препаратов. В случае необходимости одновременного применения этих препаратов, необходимо проводить мониторинг концентрации циклоспорина в плазме крови и соответственно корректировать дозу.\u003Cbr\u003EЭфавиренз\u003Cbr\u003EОдновременное применение азитромицина (600 мг/сут однократно) и эфавиренза (400 мг/сут) ежедневно в течение 7 дней не вызывало какого-либо клинически значимого фармакокинетического взаимодействия.\u003Cbr\u003EФлуконазол\u003Cbr\u003EОдновременное применение азитромицина (1200 мг однократно) не меняло фармакокинетику флуконазола (800 мг однократно). Общая экспозиция и период полувыведения азитромицина не изменялись при одновременном применении флуконазола, однако при этом наблюдали снижение Сmах азитромицина (на 18%), что не имело клинического значения.\u003Cbr\u003EИндинавир\u003Cbr\u003EОдновременное применение азитромицина (1200 мг однократно) не вызывало статистически достоверного влияния на фармакокинетику индинавира (по 800 мг три раза в сутки в течение 5 дней).\u003Cbr\u003EМетилпреднизолон\u003Cbr\u003EАзитромицин не оказывает существенного влияния на фармакокинетику метилпреднизолона.\u003Cbr\u003EНелфинавир\u003Cbr\u003EОдновременное применение азитромицина (1200 мг) и нелфинавира (по 750 мг 3 раза в день) вызывает повышение равновесных концентраций азитромицина в сыворотке крови. Клинически значимых побочных эффектов не наблюдалось и коррекции дозы азитромицина при его одновременном применении с нелфинавиром не требуется.\u003Cbr\u003EРифабутин\u003Cbr\u003EОдновременное применение азитромицина и рифабутина не влияет на концентрацию каждого из препаратов в сыворотке крови. При одновременном применении азитромицина и рифабутина иногда наблюдалась нейтропения. Несмотря на то, что нейтропения ассоциировалась с применением рифабутина, причинно-следственная связь между применением комбинации азитромицина и рифабутина и нейтропенией не установлена.\u003Cbr\u003EСилденафил\u003Cbr\u003EПри применении у здоровых добровольцев не получено доказательств влияния азитромицина (500 мг/сут ежедневно в течение 3 дней) на AUC и Сmах силденафила или его основного циркулирующего метаболита.\u003Cbr\u003EТерфенадин\u003Cbr\u003EВ фармакокинетических исследованиях не было получено доказательств взаимодействия между азитромицином и терфенадином. Сообщалось о единичных случаях, когда возможность такого взаимодействия нельзя было исключить полностью, однако не было ни одного конкретного доказательства, что такое взаимодействие имело место.\u003Cbr\u003EБыло установлено, что одновременное применение терфенадина и макролидов может вызвать аритмию и удлинение интервала QT.\u003Cbr\u003EТеофиллин\u003Cbr\u003EНе выявлено взаимодействие между азитромицином и теофиллином.\u003Cbr\u003EТриазолам/мидазолам\u003Cbr\u003EЗначительных изменений фармакокинетических показателей при одновременном применении азитромицина с триазоламом или мидазоламом в терапевтических дозах не выявлено.\u003Cbr\u003EТриметоприм/сульфаметоксазол\u003Cbr\u003EОдновременное применение триметоприма/сульфаметоксазола с азитромицином не выявило существенного влияния на Сmах, общую экспозицию или экскрецию почками триметоприма или сульфаметоксазола. Концентрация азитромицина в сыворотке крови соответствовали выявляемым в других исследованиях."},{"name":"Регистрационный номер","value":"ЛП-000887"},{"name":"Дата государственной регистрации","value":"10.01.2017"},{"name":"Владелец регистрационного удостоверения","value":"ПроМед","transition":{"type":"catalog","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["34324371:35649313","7893318:16077412"]}}},{"name":"Изготовитель","value":"Производство Медикаментов"},{"name":"Фасовщик","value":"Производство Медикаментов"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Азитромицин","transition":{"type":"catalog","params":{"categorySlug":"antibiotiki-protivomikrobnye-i-protivoparazitarnye-sredstva","categoryId":"15756919","navnodeId":"72512","glfilters":["17796364:18036872"]}}},{"name":"Срок годности","value":"965 дн."}]}},"fullSpecsGrouped":{"15630687779243877341":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Назначение","value":"бактериальные инфекции верхних отделов дыхательных путей и ЛОР-органов, бактериальные инфекции кожи и мягких тканей, бактериальные инфекции нижних отделов дыхательных путей, болезнь Лайма, бронхит, вторично инфицированные дерматозы, импетиго, инфекции мочеполовых путей (уретрит и/или цервицит), вызванные Chlamydia trachomatis, инфекционно-воспалительные заболевания, мигрирующая эритема, острые хронические и рецидивирующие инфекции мочеполовой системы, пневмония, рожистое воспаление, синусит, средний отит, тонзиллит, угревая болезнь, фарингит"},{"name":"Органы и системы","value":"выделительная система, дыхательная система, кожа, половая система"},{"name":"Показания к применению","value":"Инфекционно-воспалительные заболевания, вызванные чувствительными к препарату микроорганизмами:\u003Cbr\u003E- инфекции верхних дыхательных путей и ЛОР-органов: фарингит, тонзиллит, синусит, средний отит;\u003Cbr\u003E- инфекции нижних дыхательных путей: острый бронхит, обострение хронического бронхита, пневмония, в т.ч. вызванная атипичными возбудителями;\u003Cbr\u003E- инфекции кожи и мягких тканей: угри обыкновенные средней степени тяжести, рожа, импетиго, вторично инфицированные дерматозы;\u003Cbr\u003E- начальная стадия болезни Лайма (боррелиоз) - мигрирующая эритема (erythema migrans);\u003Cbr\u003E- инфекции мочеполовых путей, вызванные Chlamydia trachomatis (уретрит, цервицит)."},{"name":"Противопоказания","value":"- Повышенная чувствительность к азитромицину, эритромицину, другим антибиотикам группы макролидов или кетолидов, или к другим компонентам препарата;\u003Cbr\u003E- тяжелая печеночная недостаточность класс С по Чайлд-Пью);\u003Cbr\u003E- детский возраст до 12 лет с массой тела менее 45 кг;\u003Cbr\u003E- одновременный прием с эрготамином и дигидроэрготамином."},{"name":"Состав","value":"На одну капсулу:\u003Cbr\u003EДействующее вещество:\u003Cbr\u003EАзитромицина дигидрата (в пересчете на азитромицин) 500 мг или 250 мг\u003Cbr\u003EВспомогательные вещества:\u003Cbr\u003EЦеллюлоза микрокристаллическая - 40,20 мг или 109,0 мг\u003Cbr\u003EМагния стеарат - 5,70 мг или 3,75 мг\u003Cbr\u003EМасса содержимого капсулы: 570 мг или 375 мг\u003Cbr\u003EСостав оболочки капсулы № 00:\u003Cbr\u003EКорпус: диоксид титана 2,00%, желатин до 100%\u003Cbr\u003EКрышечка: диоксид титана 1,74%, закатный желтый FCF-FD&C 0,41%, желатин до 100%.\u003Cbr\u003EСостав оболочки капсулы № 0:\u003Cbr\u003EКорпус: диоксид титана 2,00%, желатин до 100%\u003Cbr\u003EКрышечка: диоксид титана 1,74%, закатный желтый FCF-FD&C 0,41%, желатин до 100%.\u003Cbr\u003E"},{"name":"Действующее вещество","value":"Азитромицин"},{"name":"Способ применения и дозы","value":"Внутрь, 1 раз в сутки по 500 мг, по крайней мере, за 1 час до или через 2 часа после приема пищи.\u003Cbr\u003EВзрослым (включая пожилых людей) и детям старше 12 лет с массой тела свыше 45 кг\u003Cbr\u003EПри инфекциях верхних и нижних дыхательных путей, лор-органов, кожи и мягких тканей: по 500 мг 1 раз в сутки в течение 3-х дней (курсовая доза - 1,5 г).\u003Cbr\u003EПри угрях обыкновенных средней степени тяжести: по 2 капсулы 250 мг 1 раз в сутки в течение 3-х дней, затем по 250 мг 2 раза в неделю в течение 9 дней. Курсовая доза 6,0 г.\u003Cbr\u003EПри болезни Лайма (боррелиоз) - мигрирующей эритеме: в первый день одновременно 2 капсулы по 500 мг, затем со 2-го по 5-й день по 500 мг ежедневно. Курсовая доза 3,0 г.\u003Cbr\u003EПри инфекциях мочеполовых путей, вызванных Chlamydia trachomatis (уретрит, цервицит): неосложненный уретрит/цервицит - одновременно 2 капсулы по 500 мг однократно.\u003Cbr\u003EПри нарушении функции почек: у пациентов с СКФ 10-80 мл/мин коррекции дозы не требуется.\u003Cbr\u003EПри нарушении функции печени: при применении у пациентов с нарушением функции печени легкой и средней степени тяжести коррекции дозы не требуется.\u003Cbr\u003EПожилые пациенты: коррекция дозы не требуется, поскольку пожилые пациенты уже могут иметь текущие проаритмогенные состояния, следует соблюдать осторожность при применении азитромицина, в связи с высоким риском развития сердечных аритмий, в том числе аритмии типа \"пируэт\"."},{"name":"Побочные действия","value":"В соответствии с рекомендациями ВОЗ частота побочных эффектов классифицируется: очень часто - не менее 10%;. часто - не менее 1%, но менее 10%; нечасто - не менее 0,1%, но менее 1%; очень редко - менее 0,01%, неизвестная частота - не может быть оценена, исходя из имеющихся данных.\u003Cbr\u003EСо стороны желудочно-кишечного тракта: очень часто - диарея; часто - тошнота, рвота, боли в животе, жидкий стул, гастрит, дисфагия, повышение секреции слюнных желез; нечасто - метеоризм, расстройство пищеварения, анорексия, вздутие живота, запор, сухость слизистой оболочки полости рта, отрыжка, язвы слизистой оболочки полости рта; очень редко - изменение цвета языка, панкреатит.\u003Cbr\u003EСо стороны обмена веществ и питания: нечасто - анорексия.\u003Cbr\u003EАллергические реакции: нечасто - ангионевротический отек реакция гиперчувствительности; неизвестная частота - анафилактическая реакция (в редких случаях со смертельным исходом).\u003Cbr\u003EСо стороны сердечно-сосудистой системы: нечасто - ощущение сердцебиения, \"приливы\" крови к лицу; неизвестная частота - аритмия типа \"пируэт\", понижение артериального давления желудочковая тахикардия, увеличение интервала QT, двунаправленная желудочковая тахикардия.\u003Cbr\u003EСо стороны нервной системы: часто - головная боль; нечасто - головокружение/вертиго, сонливость, парастезия, нервозность, бессонница, нарушение вкусовых ощущений; редко - ажитация; неизвестная частота - гиперактивность, агрессивность, беспокойство, судороги, обморок, гипестезия, потеря или извращение обоняния, бред, галлюцинации, миастения.\u003Cbr\u003EСо стороны органов чувств: нечасто - шум в ушах, вертиго, нарушение зрения; неизвестная частота - обратимое нарушение слуха вплоть до глухоты (при приеме высоких доз в течение длительного времени).\u003Cbr\u003EСо стороны дыхательной системы: нечасто - одышка, носовое кровотечение.\u003Cbr\u003EСо стороны кровеносной и лимфатической систем: нечасто - нейтропения, эозинофилия, лейкопения; очень редко - тромбоцитопения, гемолитическая анемия.\u003Cbr\u003EСо стороны опорно-двигательного аппарата: нечасто - остеоартрит, миалгия, боль в шее, боль в спине; неизвестная частота - артралгия.\u003Cbr\u003EСо стороны мочеполовой системы: нечасто - дизурия, боль в области почек; неизвестная частота - интерстициальный нефрит, острая почечная недостаточность.\u003Cbr\u003EСо стороны половых органов и молочной железы: нечасто - метроррагии, нарушение функции яичек.\u003Cbr\u003EСо стороны печени и желчевыводящих путей: нечасто - гепатит; редко - изменение лабораторных показателей функции печени, холестатическая желтуха; неизвестная частота - печеночная недостаточность, некроз печени (возможно со смертельным исходом), фульминантный гепатит.\u003Cbr\u003EСо стороны кожи и подкожных тканей: зуд, кожные высыпания, крапивница, дерматит, потливость, сухость кожи; редко - фотосенсибилизация; неизвестная частота - мультиформная эритема, синдром Стивенса-Джонсона, токсический эпидермальный некролиз.\u003Cbr\u003EИнфекционные заболевания: нечасто - кандидоз, в том числе слизистой оболочки полости рта и гениталий, пневмония, фарингит, гастроэнтерит, респираторные заболевания, ринит; неизвестная частота - псевдомембранозный колит.\u003Cbr\u003EПрочие: нечасто - астения, ощущение усталости, недомогание, отеки лица, периферические отеки, лихорадка, боль в груди.\u003Cbr\u003EЛабораторные данные: часто - снижение количества лимфоцитов, повышение количества эозинофилов, повышение количества базофилов, повышение количества моноцитов, повышение количества нейтрофилов, снижение концентрации бикарбонатов в плазме крови; нечасто - повышение активности аспартатаминострансферазы, аланинаминострансферазы, повышение концентрации билирубина в плазме крови, повышение концентрации мочевины в плазме крови, повышение концентрации креатинина в плазме крови, изменение содержания калия в плазме крови, повышение активности щелочной фосфатазы, повышение содержания хлора в плазме крови, увеличение количества тромбоцитов, повышение концентрации бикарбонатов в плазме крови, изменение содержания натрия в плазме крови."},{"name":"Фармакологическое действие","value":"Антибактериальный препарат широкого спектра действия из группы макролидов-азалидов, действует бактериостатически.\u003Cbr\u003EСвязываясь с 50S субъединицей рибосом, угнетает пептидтранслоказу на стадии трансляции, подавляет синтез белка, замедляет рост и размножение бактерий, в высоких концентрациях оказывает бактерицидный эффект. Действует на вне- и внутриклеточно расположенных возбудителей.\u003Cbr\u003EОбладает активностью в отношении ряда грамположительных, грамотрицательных, анаэробов, внутриклеточных и других микроорганизмов.\u003Cbr\u003EМикроорганизмы могут быть изначально устойчивыми к действию антибиотика или могут приобретать устойчивость к нему.\u003Cbr\u003EЧувствительны:\u003Cbr\u003Eаэробные грамположительные микроорганизмы: Staphylococcus aureus (метилциллинчувствительные), Streptococcus pneumoniae (пенициллинчувствительные), Streptococcus pyogenes;\u003Cbr\u003Eаэробные грамотрицательные микроорганизмы: Haemophilus influenzae, Haemophilus parainfluenzae, Legionella pneumophila, Moraxella catarrhalis, Pasteurella multocida, Neisseria gonorrhoeae;\u003Cbr\u003Eанаэробные микроорганизмы: Clostridium perfringens, Fusobacterium spp., Prevotella spp., Porphyromonas spp.;\u003Cbr\u003E\u003Cbr\u003Eпрочие: Chlamydia trachomatis, Chlamydia pneumoniae, Chlamydia psittaci, Mycoplasma pneumoniae, Mycoplasma hominis, Borrelia burgdoferi.\u003Cbr\u003E\u003Cbr\u003EУмеренно чувствительны или нечувствительны:\u003Cbr\u003Eаэробные грамположительные микроорганизмы: Streptococcus pneumoniae (умеренно чувствительные или резистентные к пенициллину).\u003Cbr\u003EУстойчивы:\u003Cbr\u003Eаэробные грамположительные микроорганизмы: Enterococcus faecalis, Staphylococci spp. (метициллинустойчивые), Staphylococus aureus (включая метициллинчувствительные штаммы), Staphylococus pneumoniae, Staphylococcus spp. группы А (бета-гемолитические).\u003Cbr\u003EАзитромицин не активен в отношении штаммов грамположительных бактерий, устойчивых к эритромицину.\u003Cbr\u003EАнаэробы:\u003Cbr\u003EГруппа Bacteroides fragilis."},{"name":"Фармакологическая группа","value":"антибиотик-макролид"},{"name":"Форма выпуска","value":"капсулы"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 12 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"В сухом, защищенном от света месте, при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы: временная потеря слуха, тошнота, рвота, диарея.\u003Cbr\u003EЛечение: симптоматическое."},{"name":"Применение при беременности и кормлении грудью","value":"Азитромицин при беременности и в период грудного вскармливания рекомендуется применять только в случаях, когда ожидаемая польза от его приема для матери превышает потенциальный риск для плода и ребенка.\u003Cbr\u003EПри необходимости применения препарата в период грудного вскармливания рекомендуется приостановить грудное вскармливание."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения препаратом следует соблюдать осторожность при управлении транспортными средствами и занятиями другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций в связи с возможностью развития нежелательных эффектов со стороны нервной системы и органа зрения."},{"name":"Особые указания","value":"В случае пропуска приема антибиотика, пропущенную дозу следует принять как можно раньше, а последующие дозы принимать с интервалом в 24 ч.\u003Cbr\u003EПрепарат следует принимать, по крайней мере, за 1 час до или через 2 часа после приема антацидных препаратов.\u003Cbr\u003EПри наличии симптомов нарушения функции печени, такие как астения, желтуха, потемнение мочи, склонность к кровотечениям, печеночная энцефалопатия терапию азитромицином следует прекратить и провести исследование функционального состояния печени.\u003Cbr\u003EПри нарушениях функции почек: у пациентов с СКФ 10-80 мл/мин коррекция дозы не требуется, терапию препаратом следует проводить с осторожностью под контролем состояния функции почек.\u003Cbr\u003EАзитромицин не следует применять более длительными курсами, чем указано в инструкции, так как фармакокинетические свойства препарата позволяют рекомендовать более короткий и простой режим дозирования.\u003Cbr\u003EКак и при применении других антибактериальных препаратов, при терапии азитромицином следует регулярно обследовать пациентов на наличие невосприимчивых микроорганизмов и признаки развития суперинфекций, в том числе грибковых.\u003Cbr\u003EПрименение препарата может спровоцировать развитие миастенического синдрома или вызвать обострение миастении.\u003Cbr\u003EПри длительном приеме азитромицина возможно развитие псевдомембранозного колита, вызванного Clostridium difficile, как в виде легкой диареи, так и тяжелого колита. При развитии антибиотик-ассоциированной диареи на фоне приема препарата, а также через 2 месяца после окончания терапии следует исключить клостридиальный псевдомембранозный колит. Нельзя применять препараты, тормозящие перистальтику кишечника.\u003Cbr\u003EПосле отмены терапии азитромицином реакции гиперчувствительности у некоторых пациентов могут сохраняться в течение продолжительного времени и могут потребовать специфической терапии под наблюдением врача.\u003Cbr\u003EПри лечении макролидами, в том числе, азитромицином, наблюдалось удлинение сердечной реполяризации и интервала QT, повышающих риск развития сердечных аритмий, в том числе аритмии типа \"пируэт\".\u003Cbr\u003EСледует соблюдать осторожность при применении препарата Азитромицин у пациентов с наличием проаритмогенных факторов (особенно у пожилых пациентов): с врожденным или приобретенным удлинением интервала QT, у пациентов, получающих терапию антиаритмическими препаратами классов IA (хинидин, прокаинамид), III (дофетилид, амиодарон, соталол), цизапридом, терфенадином, антипсихотическими препаратами (пимозид), антидепрессантами (циталопрам), фторхинолонами (моксифлоксацин и левофлоксацин), с нарушением водно-электролитного баланса, особенно в случае гипокалиемии или гипомагниемии, с клинически значимой брадикардией, аритмией сердца, или тяжелой сердечной недостаточностью.\u003Cbr\u003EС осторожностью:\u003Cbr\u003E- Миастения;\u003Cbr\u003E- нарушения функции печени легкой и средней степени тяжести;\u003Cbr\u003E- терминальная почечная недостаточность с СКФ (скорость клубочковой фильтрации) менее 10 мл/мин;\u003Cbr\u003E- у пациентов с наличием проаритмогенных факторов (особенно у пожилых пациентов): с врожденным или приобретенным удлинением интервала QT, у пациентов, получающих терапию антиаритмическими препаратами классов IA (хинидин, прокаинамид), III (дофетилид, амиодарон и соталол), цизапридом, терфенадином, антипсихотическими препаратами (пимозид), антидепрессантами (циталопрам), фторхинолонами (моксифлоксацин и левофлоксацин), с нарушениями водно-электролитного баланса, особенно в случае гипокалиемии или гипомагниемии, с клинически значимой брадикардией, аритмией сердца или тяжелой сердечной недостаточностью;\u003Cbr\u003E- при совместном применении циклоспорина, варфарина, дигоксина."},{"name":"Взаимодействие","value":"Антацидные препараты\u003Cbr\u003EАнтацидные препараты не влияют на биодоступность азитромицина, но уменьшают максимальную концентрацию в крови на 30%, поэтому препарат следует принимать, по крайней мере, за один час до или через два часа после приема этих препаратов и еды.\u003Cbr\u003EЦетиризин\u003Cbr\u003EОдновременное применение в течение 5 дней у здоровых добровольцев азитромицина с цетиризином (20 мг) не привело к фармакокинетическому взаимодействию и существенному изменению интервала QT.\u003Cbr\u003EДиданозин (дидезоксиинозин)\u003Cbr\u003EОдновременное применение азитромицина (1200 мг/сут) и диданозина (400 мг/сут) у 6 ВИЧ-инфицированных пациентов не выявило изменений фармакокинетических показаний диданозина по сравнению с группой плацебо.\u003Cbr\u003EДигоксин (субстраты Р-гликопротеина)\u003Cbr\u003EОдновременное применение макролидных антибиотиков, в том числе азитромицина, с субстратами Р-гликопротеина, такими как дигоксин, приводит к повышению концентрации субстрата Р-гликопротеина в сыворотке крови. Таким образом, при одновременном применении азитромицина и дигоксина необходимо учитывать возможность повышения концентрации дигоксина в сыворотке крови.\u003Cbr\u003EЗидовудин\u003Cbr\u003EОдновременное применение азитромицина (одноразовый прием 1000 мг и многократный прием 1200 мг или 600 мг) оказывает незначительное влияние на фармакокинетику, в том числе выведение почками зидовудина или его глюкуронидного метаболита. Однако применение азитромицина вызывало увеличение концентрации фосфорилированного задовудина, клинически активного метаболита в мононуклеарах периферической крови. Клиническое значение этого факта неясно.\u003Cbr\u003EАзитромицин слабо взаимодействует с изоферментами системы цитохрома Р450. Не выявлено, что азитромицин участвует в фармакокинетических взаимодействиях аналогичных эритромицину и другим макролидам. Азитромицин не является ингибитором и индуктором изоферментов цитохрома Р450.\u003Cbr\u003EАлкалоиды спорыньи\u003Cbr\u003EУчитывая теоретическую возможность возникновения эрготизма, одновременное применение азитромицина с производными алколоидов спорыньи не рекомендуется.\u003Cbr\u003EБыли проведены фармакокинетические исследования одновременного применения азитромицина и препаратов, метаболизм которых происходит с участием изоферментов системы цитохрома Р450.\u003Cbr\u003EАторвастатин\u003Cbr\u003EОдновременное применение аторвастатина (10 мг ежедневно) и азитромицина (500 мг ежедневно) не вызывало изменения концентраций аторвастатина в плазме крови (на основе анализа ингибирования ГМК-КоА-редуктазы). Однако в пострегистрационном периоде были получены отдельные сообщения о случаях рабдомиолиза у пациентов, получающих одновременно азитромицин и статины.\u003Cbr\u003EКарбамазепин\u003Cbr\u003EВ фармакокинетических исследованиях с участием здоровых добровольцев не выявлено существенного влияния на концентрацию карбамазепина и его активного метаболита в плазме крови у пациентов, получавших одновременно азитромицин.\u003Cbr\u003EЦиметидин\u003Cbr\u003EВ фармакокинетических исследованиях влияния разовой дозы циметидина на фармакокинетику азитромицина не выявлено изменений фармакокинетики азитромицина, при условии применения циметидина за 2 часа до азитромицина.\u003Cbr\u003EАнтикоагулянты непрямого действия (производные кумарина)\u003Cbr\u003EВ фармакокинетических исследованиях азитромицин не влиял на антикоагулянтный эффект однократной дозы 15 мг варфарина, принимаемого здоровыми добровольцами. Сообщалось о потенцировании антикоагулянтного эффекта после одновременного применения азитромицина и антикоагулянтов непрямого действия (производные кумарина). Несмотря на то, что причинная связь не установлена, следует учитывать необходимость проведения частого мониторинга протромбинового времени при применении азитромицина у пациентов, которые получают пероральные антикоагулянты непрямого действия (производные кумарина).\u003Cbr\u003EЦиклоспорин\u003Cbr\u003EВ фармакокинетическом исследовании с участием здоровых добровольцев, которые в течение 3 дней принимали внутрь азитромицин (500 мг/сут однократно), а затем циклоспорин (10 мг/кг/сут однократно), было выявлено достоверное повышение максимальной концентрации в плазме крови (Сmах) и площади под кривой \"концентрация-время\" (AUC0-5) циклоспорина. Следует соблюдать осторожность при одновременном применении этих препаратов. В случае необходимости одновременного применения этих препаратов, необходимо проводить мониторинг концентрации циклоспорина в плазме крови и соответственно корректировать дозу.\u003Cbr\u003EЭфавиренз\u003Cbr\u003EОдновременное применение азитромицина (600 мг/сут однократно) и эфавиренза (400 мг/сут) ежедневно в течение 7 дней не вызывало какого-либо клинически значимого фармакокинетического взаимодействия.\u003Cbr\u003EФлуконазол\u003Cbr\u003EОдновременное применение азитромицина (1200 мг однократно) не меняло фармакокинетику флуконазола (800 мг однократно). Общая экспозиция и период полувыведения азитромицина не изменялись при одновременном применении флуконазола, однако при этом наблюдали снижение Сmах азитромицина (на 18%), что не имело клинического значения.\u003Cbr\u003EИндинавир\u003Cbr\u003EОдновременное применение азитромицина (1200 мг однократно) не вызывало статистически достоверного влияния на фармакокинетику индинавира (по 800 мг три раза в сутки в течение 5 дней).\u003Cbr\u003EМетилпреднизолон\u003Cbr\u003EАзитромицин не оказывает существенного влияния на фармакокинетику метилпреднизолона.\u003Cbr\u003EНелфинавир\u003Cbr\u003EОдновременное применение азитромицина (1200 мг) и нелфинавира (по 750 мг 3 раза в день) вызывает повышение равновесных концентраций азитромицина в сыворотке крови. Клинически значимых побочных эффектов не наблюдалось и коррекции дозы азитромицина при его одновременном применении с нелфинавиром не требуется.\u003Cbr\u003EРифабутин\u003Cbr\u003EОдновременное применение азитромицина и рифабутина не влияет на концентрацию каждого из препаратов в сыворотке крови. При одновременном применении азитромицина и рифабутина иногда наблюдалась нейтропения. Несмотря на то, что нейтропения ассоциировалась с применением рифабутина, причинно-следственная связь между применением комбинации азитромицина и рифабутина и нейтропенией не установлена.\u003Cbr\u003EСилденафил\u003Cbr\u003EПри применении у здоровых добровольцев не получено доказательств влияния азитромицина (500 мг/сут ежедневно в течение 3 дней) на AUC и Сmах силденафила или его основного циркулирующего метаболита.\u003Cbr\u003EТерфенадин\u003Cbr\u003EВ фармакокинетических исследованиях не было получено доказательств взаимодействия между азитромицином и терфенадином. Сообщалось о единичных случаях, когда возможность такого взаимодействия нельзя было исключить полностью, однако не было ни одного конкретного доказательства, что такое взаимодействие имело место.\u003Cbr\u003EБыло установлено, что одновременное применение терфенадина и макролидов может вызвать аритмию и удлинение интервала QT.\u003Cbr\u003EТеофиллин\u003Cbr\u003EНе выявлено взаимодействие между азитромицином и теофиллином.\u003Cbr\u003EТриазолам/мидазолам\u003Cbr\u003EЗначительных изменений фармакокинетических показателей при одновременном применении азитромицина с триазоламом или мидазоламом в терапевтических дозах не выявлено.\u003Cbr\u003EТриметоприм/сульфаметоксазол\u003Cbr\u003EОдновременное применение триметоприма/сульфаметоксазола с азитромицином не выявило существенного влияния на Сmах, общую экспозицию или экскрецию почками триметоприма или сульфаметоксазола. Концентрация азитромицина в сыворотке крови соответствовали выявляемым в других исследованиях."},{"name":"Регистрационный номер","value":"ЛП-000887"},{"name":"Дата государственной регистрации","value":"10.01.2017"},{"name":"Владелец регистрационного удостоверения","value":"ПроМед"},{"name":"Изготовитель","value":"Производство Медикаментов"},{"name":"Фасовщик","value":"Производство Медикаментов"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Азитромицин"},{"name":"Срок годности","value":"965 дн."}]}],"transitionId":"tr_15107915857115949140"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

Где купить

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96 ₽

  • Завтра, самовывоз • 0 ₽
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    Цена 94 ₽
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  • Амоксициллин капс., 500 мг, 16 шт.
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    Амоксициллин капс., 500 мг, 16 шт.

    Рейтинг товара: 4.9 из 5
    на основе 64 оценки
    Цена 115 ₽
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  • Сумамед таб. п/о плен., 125 мг, 6 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-91169r00jae/toggleWishlist":{"skuId":"227830469","productId":1434054474,"offerId":"3_TkWVvLChzVUlFiB4pZAQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQoYeghqD57I9WEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIyt7nqwUQxdXRbBjI3dAHIPfcwQc=","sign":"zMtHGfYKVfsC3em9pSHtD8iAdKllavjJByz8fXNPM2s="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-91169r00jae/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Сумамед таб. п/о плен., 125 мг, 6 шт.

    Рейтинг товара: 4.9 из 5
    на основе 33 оценки
    Цена 219 ₽
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-91169r00jae/addToCartButton":{"offerId":"3_TkWVvLChzVUlFiB4pZAQ","skuId":"227830469","pendingCartItem":{"productId":1434054474,"offerId":"3_TkWVvLChzVUlFiB4pZAQ","showPlaceId":"OTNDnItfwRMjN9MRHuEMMrgqv2M1T--yGZ6mZ1FltJ1W8_ikdsHGKFHkkhhGIJg-nckiIvAwlQg2j42RQBvaFqkKI920fJSF8p5ApHfXB4DvWW65j1-u6LZlE2d4CQDZz29AjMuNPvK3UDAyMOoZ7pxFO70ukhsKX8xvjEPeekANq5hts0ZpRCYilVtC71nWa0Fh56K08re_BHzILPKmcA,,","feeShow":"OTNDnItfwRMjN9MRHuEMMrgqv2M1T--yGZ6mZ1FltJ1W8_ikdsHGKFHkkhhGIJg-nckiIvAwlQg2j42RQBvaFqkKI920fJSF8p5ApHfXB4DvWW65j1-u6LZlE2d4CQDZz29AjMuNPvK3UDAyMOoZ7pxFO70ukhsKX8xvjEPeekANq5hts0ZpRCYilVtC71nWa0Fh56K08re_BHzILPKmcA,,","skuId":"227830469","shopId":55106433,"price":{"applicablePriceDiscounts":[],"value":"219","currency":"RUR"},"hid":"15756919","name":"Сумамед таб. п/о плен., 125 мг, 6 шт.","label":"2zpgznk26g5","count":0,"features":[],"imageMeta":{"namespace":"mpic","groupId":11375994,"key":"img_id2587509143465782728.png"}},"quantity":{"step":1,"minimum":1,"maximum":999},"cpaUrl":"/safeclick/data=TxNGOK9vJEN7oLFLeCTKEixJYuEMI0EzvZFs82AjjgjhTwweZ7mRXd_AQ0K184sfZmy5nQz7U8xIc-qdVOMFoxnoSww2ObzLEs1KJpltGipDSanCui6QCkDTJdUMBhxLcrhkF1w97S0Dq4px-uGWx_On5fPKZgdLWQfj6AAujfSoKepGutILpQKV2rhBn6-Og3oBxYHBEE8eLReCM03m160lk5mf82i3R_ZbT4YlyF4WQSDZmbz1kYLD7-Isv87lEMjmojDW8WJEfOaa8n8qaggQTVvqch--mXzU6-KovnAl4oWwzosxjAL_6dIiUOcbIK_UBv60RnmKEBBZRL3zVxI5CC4UZaIstk4e7RVTKvVZKpHU-VgHeYwDiKR7NA4SI1HytoxKwqAnBbH5s9Tl-wx3yrpGQnjXx1rf5zAKsckFxozS3gNiA_KxOSCZZMoDOPdta8J0QTml6HayIk_n9UOVOTJpFC8bMsui7ToflmGjfG0m7qE3GiCarnVNvjI0LhpMNV6SFDU9q6gVSoweG7bjyLRVD0bxRHbmbda-i6OoKdG7PYgmN4CubdTAQGTLKi0vH_eBgJ-qry0MomXkkBkD55Yh73ULAeQp0TO4QJzzQtGjhElRprzcnk30XTYGbjf8BsxpCs-oPH29ji4noGhRckvc64xWw3o39amcI79jJxlWbjCRr5OdZZy_bxjP7HXu9j-pTrNUJETB1VqAsBNrbNBd9WjeX3fxxKMqseewGIUxprUVstmKhX8gxALU-4V1kW7nzw_piHEAnTgXxY9UonMVDIwdh1_zVLigODzQS7i353lKN41Oo3u_uZ_KknEtyf7H4ianM6quAMNXNVSKu-3aYKGJynTqJ1luq9AP8tOMRVEOwrQOKOPb-xGUaJUllFBDzryf-ntbniQf-pb3Mgul6viaDDAbq3NNpC47-8rJIGV1Sn_G0iMSn0qVUoszJg62DKasrfvT8ET2U5Y2dHjsqj1teCFKANskZknNsg8mnmEfT-QpgO3Vh9ekGiEa38ZwVwd4CWvTlucX4PyjYo1pe1cB-LbVNnMkEnmzjeczr4CAKyLlodSXYl30BQSCqy0jMvIeO6ijY32-wlrG_q75zEKXHqqLmV3KGt27lMyInl_93qBxDXvRr-pJSoLwdJwqpVbxbCd666d8nFGh9xZq0BeGUpMcJ46Xkp_PHw7LY-5q0P0HhImwCNZA7HFqVj9BSNQaD9b6GYHdV4x0IJRpmY9MkEWCVtWV__gUV1bwJalsdpgWXQISY2SJVQtpAsxAsFweUml5P5CVDF7PYS3mue-EPSTRtWl1cEyO1MxZb-L9wK0hF7tN3q-xcc6kdUd6gC8PbxBexn25-6FMYuT72In8QGH2DKQKwsLWaNoJKHzb3UuxZljYj85O9m5_s6dlepQQqIW76GHRN3YQsJ0MdQ89NT2Ujw02UaJMeXI7Uxao0PBhHlES4CnQbs-OXI2gNFdSYtXFli984F7i0kh44d_6w5WJqAzazsSKhSIk0lmifeQnbwMZV2h5Sa77IPwV1buIdwDGwPM8ChqrsOYU5oWBFEnCkPByRs5qFuAqM9vP4sJRLuHzEra58NtnMWnP2MUmBIDNOTws23M8cZbXMwfp5xSiSnYsWhMYE6XCjYt3Fna7s01QJ24nXqsed2S7jt9wdC2Y623bGRZNro0tLTKDhXfmzjzCzxgjeS-B6ZTY9q0ToOarxbwpOyE34xZ67RqmHj5ppmbJ-oTKvfIAKEPbEps2Y2YFfkkMCycZrOQUdNk4EhCdpW_Lu1x0yuxTgWAfN2GDGAuq9921ilGYJ_uhXXiQnyVFMiBCbOmB103Davqo4nU9TRQY_XRraYvNOckTf67PzZbn1Rzp4oKc-n2rJnBcOG38cYDThHBtx8VdXCD05FHL2ytyXcrFQoAZ3DJLLwA6SjLLy20jFqaCXzViSeBr4Lt7AZSsqdVU8mAAOVCIVFhfsiwkFmNIXAEpeJoC0ZErS-nFx5YUX7QllmsVUXvg2Jtbu5Dhdsur1wJKtPBrCHy9Bv1he120ML8ncfI6keCXbFsbV6blEpC5rB-EH3Y89C4UIBIv3GAs3TBp-_OWM6kXPwiZspwUOQYwteR6NaEfXsPndH_uZgutFh1aXU-rlfk3xpAxBmI_e70SzTztFtO9iO6PbDzha0I19WNJSUAUJjvzMbf9LuQG7Uuv35vifYh_qML2rz661-qqp4mIEnRIhEedHi2ZkawFzuK3I8ZGnTdVDteTrUJ8O3kF65ktH8PFUQEeF95KcdY8D8ACqXz3IOfef7BjAQBR0FlTCy1jl7dj5inIfvBQzr81-SEfKOYGFyyRhhAvK71KnGCCj8W23KJDcrX8LCy3X1oE-CqQ8BDts_WcZfQsStc8Ajk9OoI2h3OfL1M9CFpIvI7_MpDGxtuA4afWmglsgC6uZAREAfp9MUAFdiZzl-Q1-0gGWLfq-pKxigX7NhGc5HN4rnTqKVpip-hION5rmrO4yTP_LCdPOTGzcLHnN5elkfYBkqYUco_t8dS4uJtnTcZHnOX9vmo-ubAEW4-gDOMeFWlEMVxv0SYIRfVanXlzGI4fbl4nHLGNVrCILIVUv6P1It0TD4VEuXk3aBkSvSzxydVUL-jY1zeo5Ea9u9sB9pdwW-htr60vPd7gJUkas0P6VleOitRrDJEiJkr88FcsSq-Gd4cNLzM2Ce3TxJsM8nd1lA96Dmjk-ixSk3MzE8Fjl57J6GoYWXO98Vwhsp20N1_lS3_W-zGhNRC5F4tYALm2V2iyB_nj8QcDrHleRyzf5MhV-dfJZSBNN2yC3gs1OOmxxxmgtij5Z6b7G0Wp1RngtFwO1_gh3g_68ynrhGu8JFaLY7Hq7p7Qicgr2yVnksizk6b8XejXBMbfI9AqRmqi4tevdPJ5jsDUokloU9KWf7jbmSWPb1t0a2HZFjG3-Z9UxoPSLR3W9QK0C3DUWSaTqfgPYhmR6PzsWsEuRy_g8Ah97_dPOUWd0MmKGwJSwvY0O0cfE5TiIkHu21705ynatPb_a6VmI78ZmQV5UFQ32iH83PyQm-s-pQ3W0JsMDFMFanDdxxB-R03wkmI8rgiNurjdEwAs4aKlorrHOZAwGfy_ZsZPSPJC407G4NKkUgeY0QILhkp1YWhlsfR0nz8pITaegcpWucjF_Ft0FHqmNqanJQ6W3RcVzwUsO3TB0zeb3HOR-KsLIwAXWrbIKLpI8grgrdxsk2MqDYkrkmhy5aFcmFp8mUqHhZ9NO--gGdKXLWJAawut9np32cYx7-8fyeXMVM7m6oUuD1t41c4sxXIBksloX6DVINr-bkNlNfmdOqhRZXpLfxQ99bmm8gHtDiD4m04kstszn99WEfrkd7LTJhWMpSEacgDsGQDYIsU3R5oMvBSADAM99nANJAcnQzjtYCLmuc1ylyULY3o-JUQexo7wz9a7Jnb36jvcDUlp27JZ1f8oyKtqhdz2U1cMU3oCQVi4ZPppakFE4Wv4EAkCzY3i/b64e=1/sign=7f51f959ce8caf878e13c3cfc14593b9/keyno=MARKET_1/*","showUid":"17177066583537604604506003","cartLink":"/my/cart","showNotificationWhenDeleteItem":true,"isLavka":false,"isError":false,"isEats":false,"isCR":false,"isM2bEdoOnlyEnable":false,"isEatsMarketIntegration":true,"isCartButtonNext":false,"isUpsalePopupCRExp":false,"baobabClientDataAdditionToCart":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQoYeghqD57I9WEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIyt7nqwUQxdXRbBjI3dAHIPfcwQc=","sign":"zMtHGfYKVfsC3em9pSHtD8iAdKllavjJByz8fXNPM2s="},"target":"cart_addition"},"baobabClientDataDeletionFromCart":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQoYeghqD57I9WEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIyt7nqwUQxdXRbBjI3dAHIPfcwQc=","sign":"zMtHGfYKVfsC3em9pSHtD8iAdKllavjJByz8fXNPM2s="},"target":"cart_deletion"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-91169r00jae/addToCartButton":{"name":"@light/AddToCartButtonSnippet"}}}
  • Азитромицин таб. п/о плен., 500 мг, 3 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-gqxta2042a/toggleWishlist":{"skuId":"226179101","productId":1778176900,"offerId":"ErSFU_aROywN70gfEyBOfQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQoYeghqD57I9WEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIhKfzzwYQnfDsaxiPvN4HIPfcwQc=","sign":"0FUE7mQ0Q4mmfMXTYuQo0q6DXivUn1bql5PjaXduJio="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-gqxta2042a/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Азитромицин таб. п/о плен., 500 мг, 3 шт.

    Рейтинг товара: 4.9 из 5
    на основе 8 оценок
    Цена 184 ₽
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  • Азитромицин таб. п/о плен., 500 мг, 3 шт.
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    Азитромицин таб. п/о плен., 500 мг, 3 шт.

    Рейтинг товара: 4.9 из 5
    на основе 35 оценок
    Цена 124 ₽
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  • Амоксиклав таб. п/о плен., 875 мг+125 мг, 14 шт.
    –17 %
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    Амоксиклав таб. п/о плен., 875 мг+125 мг, 14 шт.

    Рейтинг товара: 5 из 5
    на основе 43 оценки
    Цена 511 ₽ вместо 618
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  • Ципрофлоксацин таб. п/о плен., 250 мг, 10 шт.
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    Ципрофлоксацин таб. п/о плен., 250 мг, 10 шт.

    Рейтинг товара: 5 из 5
    на основе 20 оценок
    Цена 44 ₽
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  • Азитромицин таб. п/о плен., 500 мг, 3 шт.
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    Азитромицин таб. п/о плен., 500 мг, 3 шт.

    Рейтинг товара: 4.8 из 5
    на основе 4 оценки
    Цена 266 ₽
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  • Азитромицин таб. п/о плен., 500 мг, 3 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-fegyjromi2w/toggleWishlist":{"skuId":"661809050","productId":1778176331,"offerId":"xcbIGJFwieUjLgBZq6JwUg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQoYeghqD57I9WEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIy6LzzwYQms/JuwIY/oqKESD33MEH","sign":"KD2IrTPacqTbXF+poW97f9p0tXqUAAItI3bWhuVZA7s="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-fegyjromi2w/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Азитромицин таб. п/о плен., 500 мг, 3 шт.

    Рейтинг товара: 4.6 из 5
    на основе 15 оценок
    Цена 107 ₽
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-fegyjromi2w/addToCartButton":{"offerId":"xcbIGJFwieUjLgBZq6JwUg","skuId":"661809050","pendingCartItem":{"productId":1778176331,"offerId":"xcbIGJFwieUjLgBZq6JwUg","showPlaceId":"OTNDnItfwRMjN9MRHuEMMrgqv2M1T--yPgA-tn9yjEFRidSgRDgDHImaNS086vPHm07j0iXm6uRfqgGr7HgiUdypPtpN1QRJlJEYSC4_VCXSbSWveHcfLbCFfI6DrY1izkMlNRdV3MB_MbyGgpW8vAxaKFG75AAkUYFTa_qNsevRnPvjJcR55J2ma5OpqMB3CBV8oTYEz2tEhX6tVLi_hA,,","feeShow":"OTNDnItfwRMjN9MRHuEMMrgqv2M1T--yPgA-tn9yjEFRidSgRDgDHImaNS086vPHm07j0iXm6uRfqgGr7HgiUdypPtpN1QRJlJEYSC4_VCXSbSWveHcfLbCFfI6DrY1izkMlNRdV3MB_MbyGgpW8vAxaKFG75AAkUYFTa_qNsevRnPvjJcR55J2ma5OpqMB3CBV8oTYEz2tEhX6tVLi_hA,,","skuId":"661809050","shopId":77075781,"price":{"applicablePriceDiscounts":[],"value":"107","currency":"RUR"},"hid":"15756919","name":"Азитромицин таб. п/о плен., 500 мг, 3 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  • Азитромицин таб. п/о плен., 125 мг, 6 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-761wkel4n5o/toggleWishlist":{"skuId":"226185803","productId":1434054451,"offerId":"54Xkfsfl_bhg4kgNN8LITQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQoYeghqD57I9WEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIs97nqwUQy6Ttaxi01YcEIPfcwQc=","sign":"M9KEgZMDusVLkibOsAgiOJl2ZrQV4IOMNO0biGFKQC0="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-761wkel4n5o/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Азитромицин таб. п/о плен., 125 мг, 6 шт.

    Рейтинг товара: 4.5 из 5
    на основе 117 оценок
    Цена 196 ₽
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  • Ципролет таб. п/о плен., 500 мг, 10 шт.
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    Ципролет таб. п/о плен., 500 мг, 10 шт.

    Рейтинг товара: 4.9 из 5
    на основе 13 оценок
    Цена 113 ₽
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  • Азитромицин таб. п/о плен., 500 мг, 3 шт.
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    Азитромицин таб. п/о плен., 500 мг, 3 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 135 ₽
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Инструкция

Показания к применению

Инфекционно-воспалительные заболевания, вызванные чувствительными к препарату микроорганизмами:
- инфекции верхних дыхательных путей и ЛОР-органов: фарингит, тонзиллит, синусит, средний отит;
- инфекции нижних дыхательных путей: острый бронхит, обострение хронического бронхита, пневмония, в т.ч. вызванная атипичными возбудителями;
- инфекции кожи и мягких тканей: угри обыкновенные средней степени тяжести, рожа, импетиго, вторично инфицированные дерматозы;
- начальная стадия болезни Лайма (боррелиоз) - мигрирующая эритема (erythema migrans);
- инфекции мочеполовых путей, вызванные Chlamydia trachomatis (уретрит, цервицит).

Противопоказания

- Повышенная чувствительность к азитромицину, эритромицину, другим антибиотикам группы макролидов или кетолидов, или к другим компонентам препарата;
- тяжелая печеночная недостаточность класс С по Чайлд-Пью);
- детский возраст до 12 лет с массой тела менее 45 кг;
- одновременный прием с эрготамином и дигидроэрготамином.

Способ применения и дозы

Внутрь, 1 раз в сутки по 500 мг, по крайней мере, за 1 час до или через 2 часа после приема пищи.
Взрослым (включая пожилых людей) и детям старше 12 лет с массой тела свыше 45 кг
При инфекциях верхних и нижних дыхательных путей, лор-органов, кожи и мягких тканей: по 500 мг 1 раз в сутки в течение 3-х дней (курсовая доза - 1,5 г).
При угрях обыкновенных средней степени тяжести: по 2 капсулы 250 мг 1 раз в сутки в течение 3-х дней, затем по 250 мг 2 раза в неделю в течение 9 дней. Курсовая доза 6,0 г.
При болезни Лайма (боррелиоз) - мигрирующей эритеме: в первый день одновременно 2 капсулы по 500 мг, затем со 2-го по 5-й день по 500 мг ежедневно. Курсовая доза 3,0 г.
При инфекциях мочеполовых путей, вызванных Chlamydia trachomatis (уретрит, цервицит): неосложненный уретрит/цервицит - одновременно 2 капсулы по 500 мг однократно.
При нарушении функции почек: у пациентов с СКФ 10-80 мл/мин коррекции дозы не требуется.
При нарушении функции печени: при применении у пациентов с нарушением функции печени легкой и средней степени тяжести коррекции дозы не требуется.
Пожилые пациенты: коррекция дозы не требуется, поскольку пожилые пациенты уже могут иметь текущие проаритмогенные состояния, следует соблюдать осторожность при применении азитромицина, в связи с высоким риском развития сердечных аритмий, в том числе аритмии типа "пируэт".
Полная инструкция
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Азитромицин капс.
Азитромицин капс., 500 мг, 3 шт.
4.7
(156)
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14 вопросов
Инструкция

96 ₽

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4.7
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У продавца:156 оценок·20 отзывов
У всех продавцов:545 оценок·103 отзыва
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user avatar
2 месяца назад • Иван Куликов • Куплен на Маркете
Достоинства: цена
Недостатки: по рецепту на второй день пришел терапевт после обеда и выписал рецепт,,,по сути полтара суток организму не было помоши
Комментарий: нужно время пока пью лекарства
user avatar
3 месяца назад • Елена Хакимова • Куплен на Маркете
Достоинства: удобство приёма, всего 3 дня. удобно, что не надо как другие антибиотики развозить в воде, типа Флемоксин-который имеет терпкий вкус.
user avatar
2 года назад • Ольга Мещерякова • Куплен на Маркете
Достоинства: Очень хороший антибиотик. Большое преимущество: принимать по 1 капсуле в день, и всего 3 дня. Эффективен при многих заболеваниях (см. инструкцию по применению)
Недостатки: нет
Комментарий: Не очень страдает кишечник.
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  • Азитромицин капс., 250 мг, 6 шт.
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    Азитромицин капс., 250 мг, 6 шт.

    Цена 94 ₽
  • Омепразол капс., 20 мг, 30 шт.
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    Омепразол капс., 20 мг, 30 шт.

    Цена 37 ₽
  • Нимесулид-ЛекТ таб., 100 мг, 20 шт.
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    Нимесулид-ЛекТ таб., 100 мг, 20 шт.

    Цена 85 ₽
  • Кетанов таб. п/о плен., 10 мг, 20 шт.
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    Кетанов таб. п/о плен., 10 мг, 20 шт.

    Цена 97 ₽
  • Ибупрофен-АКОС таб. п/о плен., 400 мг, 20 шт.
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    Ибупрофен-АКОС таб. п/о плен., 400 мг, 20 шт.

    Цена 63 ₽ вместо 64
  • Амоксициллин капс., 500 мг, 16 шт.
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    Амоксициллин капс., 500 мг, 16 шт.

    Цена 115 ₽
  • Vitamin D3, 10000 МЕ, 120 шт.
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    Vitamin D3, 10000 МЕ, 120 шт.

    Цена 1 210 ₽ вместо 2 455
  • Нимесулид таб., 100 мг, 30 шт.
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    Нимесулид таб., 100 мг, 30 шт.

    Цена 90 ₽
  • Реклама
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  • Сумамед таб. п/о плен., 125 мг, 6 шт.
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    Сумамед таб. п/о плен., 125 мг, 6 шт.

    Цена 219 ₽
  • Азитромицин таб. п/о плен., 500 мг, 3 шт.
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    Азитромицин таб. п/о плен., 500 мг, 3 шт.

    Цена 184 ₽
  • Азитромицин таб. п/о плен., 500 мг, 3 шт.
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    Азитромицин таб. п/о плен., 500 мг, 3 шт.

    Цена 124 ₽
  • БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:997279548_12/content/content/gallery":{"title":"БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/5131700/img_id5468924246027050142.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5131700/img_id5468924246027050142.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5131700/img_id5468924246027050142.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5131700/img_id5468924246027050142.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5131700/img_id5468924246027050142.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5131700/img_id5468924246027050142.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4408567/img_id147222889702037708.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4408567/img_id147222889702037708.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4408567/img_id147222889702037708.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4408567/img_id147222889702037708.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4408567/img_id147222889702037708.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4408567/img_id147222889702037708.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQoYeghqD57I9WEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCLyOxdsDEPTRh9H5Ahj03/kHINrZwQc=","sign":"2UIzaV9YqJDzZOc2j9sXuHzVumyTA1sMHuBuVhO1qow="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:997279548_12/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.

    Цена 2 025 ₽ вместо 3 500
  • Амоксиклав таб. п/о плен., 875 мг+125 мг, 14 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1434054457_13/content/content/gallery":{"title":"Амоксиклав таб. п/о плен., 875 мг+125 мг, 14 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/1364191/img_id5042357650685675981.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/1364191/img_id5042357650685675981.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/1364191/img_id5042357650685675981.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/1364191/img_id5042357650685675981.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/1364191/img_id5042357650685675981.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/1364191/img_id5042357650685675981.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/7660527/img_id7486182607985937073.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/7660527/img_id7486182607985937073.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/7660527/img_id7486182607985937073.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/7660527/img_id7486182607985937073.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/7660527/img_id7486182607985937073.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/7660527/img_id7486182607985937073.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4497593/img_id6545272269182513172.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4497593/img_id6545272269182513172.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4497593/img_id6545272269182513172.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4497593/img_id6545272269182513172.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4497593/img_id6545272269182513172.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4497593/img_id6545272269182513172.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQoYeghqD57I9WEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCLne56sFEIHV0GwYxJzQByD33MEH","sign":"zqxotYf2M/0EbOV36j3CDtlBKGpSuJPYqlZte6hMxd4="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1434054457_13/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Амоксиклав таб. п/о плен., 875 мг+125 мг, 14 шт.

    Цена 511 ₽ вместо 618
  • Ибупрофен таб. п/о плен., 200 мг, 50 шт.
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    Ибупрофен таб. п/о плен., 200 мг, 50 шт.

    Цена 61 ₽ вместо 62
  • Ципрофлоксацин таб. п/о плен., 250 мг, 10 шт.
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    Ципрофлоксацин таб. п/о плен., 250 мг, 10 шт.

    Цена 44 ₽
  • Азитромицин таб. п/о плен., 500 мг, 3 шт.
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    Азитромицин таб. п/о плен., 500 мг, 3 шт.

    Цена 266 ₽
  • Кеторол Экспресс таб. дисперг., 10 мг, 20 шт.
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    Кеторол Экспресс таб. дисперг., 10 мг, 20 шт.

    Цена 91 ₽
  • Пастилки California Gold Nutrition Vitamin D3 gummies со вкусом фруктов и ягод, 280 г, 90 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780868129_18/content/content/gallery":{"title":"Пастилки California Gold Nutrition Vitamin D3 gummies со вкусом фруктов и ягод, 280 г, 90 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/5221216/img_id7471792949168823942.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5221216/img_id7471792949168823942.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5221216/img_id7471792949168823942.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5221216/img_id7471792949168823942.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5221216/img_id7471792949168823942.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5221216/img_id7471792949168823942.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 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    Пастилки California Gold Nutrition Vitamin D3 gummies со вкусом фруктов и ягод, 280 г, 90 шт.

    Цена 421 ₽ вместо 425
  • Азитромицин таб. п/о плен., 500 мг, 3 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778176331_19/content/content/toggleWishlist":{"skuId":"661809050","productId":1778176331,"offerId":"xcbIGJFwieUjLgBZq6JwUg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQoYeghqD57I9WEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCMui888GEJrPybsCGP6KihEg99zBBw==","sign":"2ESPm25OzJggGW2FXn89gJ4buH/ImKHXbFEe/v/qUDc="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778176331_19/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Азитромицин таб. п/о плен., 500 мг, 3 шт.

    Цена 107 ₽
  • Азитромицин таб. п/о плен., 125 мг, 6 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1434054451_20/content/content/gallery":{"title":"Азитромицин таб. п/о плен., 125 мг, 6 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/1360806/img_id3333424220888736134.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/1360806/img_id3333424220888736134.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/1360806/img_id3333424220888736134.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/1360806/img_id3333424220888736134.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/1360806/img_id3333424220888736134.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/1360806/img_id3333424220888736134.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5215227/img_id2867061684069505730.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5215227/img_id2867061684069505730.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5215227/img_id2867061684069505730.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5215227/img_id2867061684069505730.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5215227/img_id2867061684069505730.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5215227/img_id2867061684069505730.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5360356/img_id6695547539430140502.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5360356/img_id6695547539430140502.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5360356/img_id6695547539430140502.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5360356/img_id6695547539430140502.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5360356/img_id6695547539430140502.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5360356/img_id6695547539430140502.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQoYeghqD57I9WEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCLPe56sFEMuk7WsYtNWHBCD33MEH","sign":"BJAmQRKjph7kPEX1aMfSVJhQMekqRs6CCvfD1Vbrym4="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1434054451_20/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Азитромицин таб. п/о плен., 125 мг, 6 шт.

    Цена 196 ₽
  • Реклама
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    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  • ЛимфоТранзит концентрат напитка фл., 100 мл
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780857920_22/content/content/gallery":{"title":"ЛимфоТранзит концентрат напитка фл., 100 мл","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQoYeghqD57I9WEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCMD4ltEGEI2Jl7wCGNW7oQYg19zBBw==","sign":"Q6rAqSi8/L0edL9PtxaqNuhRQqc3r3zHSsgBccz2EWY="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780857920_22/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    ЛимфоТранзит концентрат напитка фл., 100 мл

    Цена 332 ₽ вместо 390
  • Ципролет таб. п/о плен., 500 мг, 10 шт.
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    Ципролет таб. п/о плен., 500 мг, 10 шт.

    Цена 113 ₽
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