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Описание

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Бараклюд таб. п/о плен., 0.5 мг, 30 шт.

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У продавца: 
нет • На Маркете: 4.9
(8)
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Коротко о товаре

Артикул Маркета
3123949510
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
{"widgets":{"@card/SpecsList":{"/content/page/fancyPage/productSpecsList":{"wrapperProps":{"margins":{"top":4,"bottom":4}},"specsLimit":5,"title":"Коротко о товаре","titleSize":"14","type":"minimal","offset":"s","isHealthCategory":true,"forceShowWidget":true,"withFridge":true}}},"meta":{"/content/page/fancyPage/productSpecsList":{"name":"@card/SpecsList"}},"collections":{"minimalSpecs":{"15364241693130139808":{"specItems":[{"name":"Артикул Маркета","value":"3123949510","withCopyValueButton":true},{"name":"тип препарата","value":"рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"назначение","value":"вирусный гепатит B","transition":{"type":"list","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["36476390:36618377"]}}},{"name":"действующее вещество","value":"Энтекавир","transition":{"type":"list","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["27144131:28709394"]}}},{"name":"возраст","value":"от 18 лет"},{"name":"форма выпуска","value":"таблетки"},{"name":"страна-производитель","value":"США"}]}},"compactSpecs":{"15364241693130139808":{"specItems":[{"name":"Артикул Маркета","value":"3123949510","withCopyValueButton":true},{"name":"Тип препарата","value":"Рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"Назначение","value":"Вирусный гепатит B","transition":{"type":"list","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["36476390:36618377"]}}},{"name":"Действующее вещество","value":"Энтекавир","transition":{"type":"list","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["27144131:28709394"]}}},{"name":"Возраст","value":"От 18 лет"}]}},"fullSpecs":{"15364241693130139808":{"specItems":[{"name":"Тип препарата","value":"лекарственный препарат","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["34324371:35649313"]}}},{"name":"Рецептурный препарат","value":"да","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["27272850:1,0"]}}},{"name":"Органы и системы","value":"печень, пищеварительная система","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["34045610:34516029,34516020"]}}},{"name":"Назначение","value":"вирусный гепатит B","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["36476390:36618377"]}}},{"name":"Показания к применению","value":"Хронический гепатит В у взрослых с:\u003Cbr /\u003E- компенсированным поражением печени и наличием вирусной репликации, повышения уровня активности сывороточных трансаминаз (аланинаминотрансфераза, АЛТ; или аспартатаминотрансфераза, ACT) и гистологических признаков воспалительного процесса в печени и/или фиброза,\u003Cbr /\u003E- декомпенсированным поражением печени."},{"name":"Противопоказания","value":"- повышенная чувствительность к энтекавиру или любому другому компоненту препарата;\u003Cbr\u003E- детский возраст до 18 лет (эффективность и безопасность не изучены);\u003Cbr\u003E- редкая наследственная непереносимость лактозы, дефицит лактазы или глюкозо-галактозная мальабсорбция."},{"name":"Состав","value":"Каждая таблетка, покрытая пленочной оболочкой, содержит активное вещество: энтекавира 0,5 мг или 1,0 мг.\u003Cbr /\u003EВспомогательные вещества: лактозы моногидрат 120,5 мг или 241,0 мг, целлюлоза микрокристаллическая 65,0 мг или 130,0 мг, кросповидон 8,0 мг или 16,0 мг, повидон К 30 5,0 мг или 10,0 мг, магния стеарат 1,0 мг или 2,0 мг, опадрай белый 6,0 мг - таблетки 0,5 мг или опадрай розовый 12,0 мг - таблетки 1,0 мг.\u003Cbr /\u003EСостав Опадрай белый: титана диоксид (31,25%), гипромеллоза 3 сР (29,875 %), гипромеллоза 6сР (29,875 %), макрогол 400 (8%), полисорбат 80 (1,0 %).\u003Cbr /\u003EСостав Опадрай розовый: титана диоксид (31,04 %), гипромеллоза 6 сР (62,5%), макрогол 400 (6,250 %), краситель железа оксид красный (Е172, CFR21)) (0,210%)."},{"name":"Действующее вещество","value":"Энтекавир","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["27144131:28709394"]}}},{"name":"Способ применения и дозы","value":"Энтекавир следует принимать внутрь натощак (то есть, не менее чем через 2 часа после еды и не позднее, чем за 2 часа до следующего приема пищи).\u003Cbr\u003EРекомендуемая доза энтекавира для пациентов с компенсированным поражением печени составляет 0,5 мг один раз в день.\u003Cbr\u003EРезистентным к ламивудину пациентам (то есть, пациентам в анамнезе с виремией вирусом гепатита В, сохраняющейся на фоне терапии ламивудином, или пациентам с подтвержденной резистентностью к ламивудину) рекомендуется назначать 1 мг энтекавира один раз в день. Пациентам с декомпенсированным поражением печени рекомендуется назначать 1 мг энтекавира один раз в день.\u003Cbr\u003EПациенты с почечной недостаточностью. Клиренс энтекавира уменьшается при снижении клиренса креатинина. Рекомендуется коррекция дозы энтекавира пациентам с клиренсом креатинина \u003C50 мл/мин, в том числе находящимся на гемодиализе и длительном амбулаторном перитонеальном диализе."},{"name":"Побочные действия","value":"Со стороны пищеварительной системы редко (≥ 1/1000, \u003C 1/100): диарея, диспепсия, тошнота, рвота.\u003Cbr\u003EСо стороны центральной нервной системы часто (≥ 1/100, \u003C 1/10): головная боль, утомляемость; редко (≥ 1/1000, \u003C 1/100): бессонница, головокружение, сонливость.\u003Cbr\u003EПостмаркетинговые данные (частота не может быть определена):\u003Cbr\u003EСо стороны иммунной системы: анафилактоидная реакция\u003Cbr\u003EСо стороны кожи и подкожной клетчатки: алопеция, сыпь.\u003Cbr\u003EСо стороны печени: повышение активности трансаминаз.\u003Cbr\u003EСо стороны обмена веществ: лактоацидоз (общая усталость, тошнота, рвота, боль в брюшной полости, внезапное снижение массы тела, одышка, учащенное дыхание, мышечная слабость), особенно у пациентов с декомпенсированным поражением печени.\u003Cbr\u003EКроме этого, у пациентов с декомпенсированным поражением печени отмечались дополнительно следующие побочные эффекты:\u003Cbr\u003EЧасто: снижение концентрации бикарбоната в крови, повышение активности АЛТ и концентрации билирубина более чем в 2 раза по сравнению с верхней границей нормы, концентрация альбумина менее 2,5 г/дл, возрастание активности липазы более чем в 3 раза по сравнению с нормой, концентрация тромбоцитов ниже 50000/ммЗ; редко: почечная недостаточность."},{"name":"Фармакологическое действие","value":"Энтекавир является аналогом нуклеозида гуанозина с мощной и селективной активностью в отношении HBV полимеразы. Энтекавир фосфорилируется с образованием активного трифосфата (ТФ), имеющего внутриклеточный период полужизни 15 часов. Внутриклеточная концентрация ТФ прямо связана с внеклеточным уровнем энтекавира, причем не отмечается значительного накопления препарата после начального уровня \"плато\". Путем конкуренции с естественным субстратом, деоксигуанозина-ТФ, энтекавира-ТФ ингибирует все 3 функциональные активности вирусной полимеразы: (1) прайминг HBV полимеразы, (2) обратную транскрипцию негативной нити из прегеномной и РНК и (3) синтез позитивной нити HBV ДНК. Энтекавира-ТФ является слабым ингибитором клеточных ДНК полимераз а, Р и 5 с Ki 18-40 мкМ. Кроме того, при высоких концентрациях энтекавира-ТФ и энтекавира не отмечены побочные эффекты в отношении у полимеразы и синтеза ДНК в митохондриях клеток HepG2."},{"name":"Фармакологическая группа","value":"противовирусное средство","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["34045110:34518654"]}}},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"Хранить при температуре 15- 25°С."},{"name":"Передозировка","value":"Имеются ограниченные данные о случаях передозировки препарата у пациентов. У здоровых добровольцев, получавших до 20 мг препарата в день в течение до 14 дней или однократные дозы до 40 мг, не было никаких неожиданных побочных явлений. В случае передозировки за пациентом должно проводиться тщательное медицинское наблюдение и при необходимости стандартная поддерживающая терапия."},{"name":"Применение при беременности и кормлении грудью","value":"Должен приниматься во время беременности, только если потенциальная польза применения превышает потенциальный риск для плода. Данных о проникновении энтекавира в женское молоко нет. Кормить грудью при применении препарата не рекомендуется."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Не описано."},{"name":"Особые указания","value":"При лечении аналогами нуклеозидов, в том числе энтекавиром, в виде монотерапии и в комбинации с антиретровирусными препаратами описаны случаи лактоацидоза и выраженной гепатомегалии со стеатозом, иногда приводившие к смерти пациента. Симптомы, которые могут указывать на развитие лактоацидоза: общая усталость, тошнота, рвота, боль в брюшной полости, внезапное снижение массы тела, одышка, учащенное дыхание, мышечная слабость. Факторами риска являются женский пол, ожирение, длительное использование нуклеозидных аналогов, гепатомегалии. При появлении указанных симптомов или получении лабораторного подтверждения лактоацидоза следует прекратить лечение препаратом.\u003Cbr\u003EОписаны случаи обострения гепатита после отмены противовирусной терапии, в том числе энтекавира. Большинство таких случаев проходили без лечения. Однако могут развиваться тяжелые обострения, в том числе фатальные.\u003Cbr\u003EПричинная связь этих обострений с отменой терапии неизвестна. После прекращения лечения необходимо периодически контролировать функцию печени. При необходимости противовирусная терапия может быть возобновлена.\u003Cbr\u003EПациенты с сочетанной гепатит В/ВИЧ-инфекцией. Следует учитывать, что при назначении энтекавира пациентам с сочетанной инфекцией ВИЧ, не получающим антиретровирусную терапию, возможен риск развития устойчивых штаммов ВИЧ. Энтекавир не был изучен для лечения ВИЧ инфекции и не рекомендуется для подобного использования.\u003Cbr\u003EПациенты с сочетанной гепатит В/гепатит С/гепатит D инфекцией. Данных об эффективности энтекавира у пациентов с сочетанной гепатит В/гепатит С/гепатит D инфекциями нет.\u003Cbr\u003EПациенты с декомпенсированным поражением печени. Отмечен высокий риск развития серьезных побочных эффектов со стороны печени, в частности у пациентов с декомпенсированным поражением печени класса С по классификации Чайлд-Пью.\u003Cbr\u003EТакже эти пациенты более подвержены риску развития лактоацидоза и таких специфических побочных эффектов со стороны почек, как гепаторенальный синдром. В связи с этим следует осуществлять тщательное наблюдение за пациентами на предмет выявления клинических признаков лактоацидоза и нарушения функции почек, а также проводить соответствующие лабораторные анализы у данной группы пациентов (активность \"печеночных\" ферментов, концентрация молочной кислоты в крови, концентрация креатинина в сыворотке крови). \u003Cbr\u003EЛамивудин-резистентные пациенты. Наличие мутаций устойчивости у вируса гепатита В к ламивудину повышает риск развития резистентности к энтекавиру. В связи с этим у ламивудин-резистентных пациентов требуется проведение частого мониторинга вирусной нагрузки и при необходимости соответствующее обследование на выявление мутаций устойчивости.\u003Cbr\u003EПациенты с нарушением функции почек. Для пациентов с нарушениями функции почек рекомендуется коррекция режима дозирования.\u003Cbr\u003EПациенты, перенесшие трансплантацию печени. Безопасность и эффективность энтекавира у пациентов, перенесших трансплантацию печени, неизвестны. Следует тщательно контролировать функцию почек перед и во время лечения энтекавиром у пациентов, перенесших трансплантацию печени, и получающих иммунодепрессанты, которые могут влиять на функцию почек, такие как циклоспорин и такролимус.\u003Cbr\u003EОбщая информация для пациентов. Следует информировать пациентов, что терапия энтекавиром не уменьшает риск передачи гепатита В и, поэтому, соответствующие меры предосторожности должны быть предприняты."},{"name":"Взаимодействие","value":"Поскольку энтекавир выводится преимущественно почками, при одновременном введении энтекавира и лекарств, снижающих функцию почек или конкурирующих на уровне канальцевой секреции, возможно увеличение концентрации в сыворотке энтекавира или этих лекарств. При одновременном назначении энтекавира с ламивудином, адефовиром или тенофовиром не выявлено значимых лекарственных взаимодействий.\u003Cbr\u003E\nВзаимодействия энтекавира с другими препаратами, выводящимися почками или влияющими на функцию почек, не изучены. За пациентами должно проводиться тщательное медицинское наблюдение при одновременном назначении энтекавира с такими препаратами."},{"name":"Регистрационный номер","value":"ЛСР-000035"},{"name":"Дата государственной регистрации","value":"22.07.2021"},{"name":"Владелец регистрационного удостоверения","value":"Bristol-Myers Squibb","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["34324371:35649313","7893318:16002946"]}}},{"name":"Изготовитель","value":"Bristol-Myers Squibb"},{"name":"Фасовщик","value":"Bristol-Myers Squibb"},{"name":"Страна бренда","value":"США"},{"name":"Страна-производитель","value":"США"},{"name":"Название препарата","value":"Бараклюд","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["17796364:18008582"]}}},{"name":"Срок годности","value":"36 мес."}]}},"fullSpecsGrouped":{"15364241693130139808":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"печень, пищеварительная система"},{"name":"Назначение","value":"вирусный гепатит B"},{"name":"Показания к применению","value":"Хронический гепатит В у взрослых с:\u003Cbr /\u003E- компенсированным поражением печени и наличием вирусной репликации, повышения уровня активности сывороточных трансаминаз (аланинаминотрансфераза, АЛТ; или аспартатаминотрансфераза, ACT) и гистологических признаков воспалительного процесса в печени и/или фиброза,\u003Cbr /\u003E- декомпенсированным поражением печени."},{"name":"Противопоказания","value":"- повышенная чувствительность к энтекавиру или любому другому компоненту препарата;\u003Cbr\u003E- детский возраст до 18 лет (эффективность и безопасность не изучены);\u003Cbr\u003E- редкая наследственная непереносимость лактозы, дефицит лактазы или глюкозо-галактозная мальабсорбция."},{"name":"Состав","value":"Каждая таблетка, покрытая пленочной оболочкой, содержит активное вещество: энтекавира 0,5 мг или 1,0 мг.\u003Cbr /\u003EВспомогательные вещества: лактозы моногидрат 120,5 мг или 241,0 мг, целлюлоза микрокристаллическая 65,0 мг или 130,0 мг, кросповидон 8,0 мг или 16,0 мг, повидон К 30 5,0 мг или 10,0 мг, магния стеарат 1,0 мг или 2,0 мг, опадрай белый 6,0 мг - таблетки 0,5 мг или опадрай розовый 12,0 мг - таблетки 1,0 мг.\u003Cbr /\u003EСостав Опадрай белый: титана диоксид (31,25%), гипромеллоза 3 сР (29,875 %), гипромеллоза 6сР (29,875 %), макрогол 400 (8%), полисорбат 80 (1,0 %).\u003Cbr /\u003EСостав Опадрай розовый: титана диоксид (31,04 %), гипромеллоза 6 сР (62,5%), макрогол 400 (6,250 %), краситель железа оксид красный (Е172, CFR21)) (0,210%)."},{"name":"Действующее вещество","value":"Энтекавир"},{"name":"Способ применения и дозы","value":"Энтекавир следует принимать внутрь натощак (то есть, не менее чем через 2 часа после еды и не позднее, чем за 2 часа до следующего приема пищи).\u003Cbr\u003EРекомендуемая доза энтекавира для пациентов с компенсированным поражением печени составляет 0,5 мг один раз в день.\u003Cbr\u003EРезистентным к ламивудину пациентам (то есть, пациентам в анамнезе с виремией вирусом гепатита В, сохраняющейся на фоне терапии ламивудином, или пациентам с подтвержденной резистентностью к ламивудину) рекомендуется назначать 1 мг энтекавира один раз в день. Пациентам с декомпенсированным поражением печени рекомендуется назначать 1 мг энтекавира один раз в день.\u003Cbr\u003EПациенты с почечной недостаточностью. Клиренс энтекавира уменьшается при снижении клиренса креатинина. Рекомендуется коррекция дозы энтекавира пациентам с клиренсом креатинина \u003C50 мл/мин, в том числе находящимся на гемодиализе и длительном амбулаторном перитонеальном диализе."},{"name":"Побочные действия","value":"Со стороны пищеварительной системы редко (≥ 1/1000, \u003C 1/100): диарея, диспепсия, тошнота, рвота.\u003Cbr\u003EСо стороны центральной нервной системы часто (≥ 1/100, \u003C 1/10): головная боль, утомляемость; редко (≥ 1/1000, \u003C 1/100): бессонница, головокружение, сонливость.\u003Cbr\u003EПостмаркетинговые данные (частота не может быть определена):\u003Cbr\u003EСо стороны иммунной системы: анафилактоидная реакция\u003Cbr\u003EСо стороны кожи и подкожной клетчатки: алопеция, сыпь.\u003Cbr\u003EСо стороны печени: повышение активности трансаминаз.\u003Cbr\u003EСо стороны обмена веществ: лактоацидоз (общая усталость, тошнота, рвота, боль в брюшной полости, внезапное снижение массы тела, одышка, учащенное дыхание, мышечная слабость), особенно у пациентов с декомпенсированным поражением печени.\u003Cbr\u003EКроме этого, у пациентов с декомпенсированным поражением печени отмечались дополнительно следующие побочные эффекты:\u003Cbr\u003EЧасто: снижение концентрации бикарбоната в крови, повышение активности АЛТ и концентрации билирубина более чем в 2 раза по сравнению с верхней границей нормы, концентрация альбумина менее 2,5 г/дл, возрастание активности липазы более чем в 3 раза по сравнению с нормой, концентрация тромбоцитов ниже 50000/ммЗ; редко: почечная недостаточность."},{"name":"Фармакологическое действие","value":"Энтекавир является аналогом нуклеозида гуанозина с мощной и селективной активностью в отношении HBV полимеразы. Энтекавир фосфорилируется с образованием активного трифосфата (ТФ), имеющего внутриклеточный период полужизни 15 часов. Внутриклеточная концентрация ТФ прямо связана с внеклеточным уровнем энтекавира, причем не отмечается значительного накопления препарата после начального уровня \"плато\". Путем конкуренции с естественным субстратом, деоксигуанозина-ТФ, энтекавира-ТФ ингибирует все 3 функциональные активности вирусной полимеразы: (1) прайминг HBV полимеразы, (2) обратную транскрипцию негативной нити из прегеномной и РНК и (3) синтез позитивной нити HBV ДНК. Энтекавира-ТФ является слабым ингибитором клеточных ДНК полимераз а, Р и 5 с Ki 18-40 мкМ. Кроме того, при высоких концентрациях энтекавира-ТФ и энтекавира не отмечены побочные эффекты в отношении у полимеразы и синтеза ДНК в митохондриях клеток HepG2."},{"name":"Фармакологическая группа","value":"противовирусное средство"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Хранить при температуре 15- 25°С."},{"name":"Передозировка","value":"Имеются ограниченные данные о случаях передозировки препарата у пациентов. У здоровых добровольцев, получавших до 20 мг препарата в день в течение до 14 дней или однократные дозы до 40 мг, не было никаких неожиданных побочных явлений. В случае передозировки за пациентом должно проводиться тщательное медицинское наблюдение и при необходимости стандартная поддерживающая терапия."},{"name":"Применение при беременности и кормлении грудью","value":"Должен приниматься во время беременности, только если потенциальная польза применения превышает потенциальный риск для плода. Данных о проникновении энтекавира в женское молоко нет. Кормить грудью при применении препарата не рекомендуется."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Не описано."},{"name":"Особые указания","value":"При лечении аналогами нуклеозидов, в том числе энтекавиром, в виде монотерапии и в комбинации с антиретровирусными препаратами описаны случаи лактоацидоза и выраженной гепатомегалии со стеатозом, иногда приводившие к смерти пациента. Симптомы, которые могут указывать на развитие лактоацидоза: общая усталость, тошнота, рвота, боль в брюшной полости, внезапное снижение массы тела, одышка, учащенное дыхание, мышечная слабость. Факторами риска являются женский пол, ожирение, длительное использование нуклеозидных аналогов, гепатомегалии. При появлении указанных симптомов или получении лабораторного подтверждения лактоацидоза следует прекратить лечение препаратом.\u003Cbr\u003EОписаны случаи обострения гепатита после отмены противовирусной терапии, в том числе энтекавира. Большинство таких случаев проходили без лечения. Однако могут развиваться тяжелые обострения, в том числе фатальные.\u003Cbr\u003EПричинная связь этих обострений с отменой терапии неизвестна. После прекращения лечения необходимо периодически контролировать функцию печени. При необходимости противовирусная терапия может быть возобновлена.\u003Cbr\u003EПациенты с сочетанной гепатит В/ВИЧ-инфекцией. Следует учитывать, что при назначении энтекавира пациентам с сочетанной инфекцией ВИЧ, не получающим антиретровирусную терапию, возможен риск развития устойчивых штаммов ВИЧ. Энтекавир не был изучен для лечения ВИЧ инфекции и не рекомендуется для подобного использования.\u003Cbr\u003EПациенты с сочетанной гепатит В/гепатит С/гепатит D инфекцией. Данных об эффективности энтекавира у пациентов с сочетанной гепатит В/гепатит С/гепатит D инфекциями нет.\u003Cbr\u003EПациенты с декомпенсированным поражением печени. Отмечен высокий риск развития серьезных побочных эффектов со стороны печени, в частности у пациентов с декомпенсированным поражением печени класса С по классификации Чайлд-Пью.\u003Cbr\u003EТакже эти пациенты более подвержены риску развития лактоацидоза и таких специфических побочных эффектов со стороны почек, как гепаторенальный синдром. В связи с этим следует осуществлять тщательное наблюдение за пациентами на предмет выявления клинических признаков лактоацидоза и нарушения функции почек, а также проводить соответствующие лабораторные анализы у данной группы пациентов (активность \"печеночных\" ферментов, концентрация молочной кислоты в крови, концентрация креатинина в сыворотке крови). \u003Cbr\u003EЛамивудин-резистентные пациенты. Наличие мутаций устойчивости у вируса гепатита В к ламивудину повышает риск развития резистентности к энтекавиру. В связи с этим у ламивудин-резистентных пациентов требуется проведение частого мониторинга вирусной нагрузки и при необходимости соответствующее обследование на выявление мутаций устойчивости.\u003Cbr\u003EПациенты с нарушением функции почек. Для пациентов с нарушениями функции почек рекомендуется коррекция режима дозирования.\u003Cbr\u003EПациенты, перенесшие трансплантацию печени. Безопасность и эффективность энтекавира у пациентов, перенесших трансплантацию печени, неизвестны. Следует тщательно контролировать функцию почек перед и во время лечения энтекавиром у пациентов, перенесших трансплантацию печени, и получающих иммунодепрессанты, которые могут влиять на функцию почек, такие как циклоспорин и такролимус.\u003Cbr\u003EОбщая информация для пациентов. Следует информировать пациентов, что терапия энтекавиром не уменьшает риск передачи гепатита В и, поэтому, соответствующие меры предосторожности должны быть предприняты."},{"name":"Взаимодействие","value":"Поскольку энтекавир выводится преимущественно почками, при одновременном введении энтекавира и лекарств, снижающих функцию почек или конкурирующих на уровне канальцевой секреции, возможно увеличение концентрации в сыворотке энтекавира или этих лекарств. При одновременном назначении энтекавира с ламивудином, адефовиром или тенофовиром не выявлено значимых лекарственных взаимодействий.\u003Cbr\u003E\nВзаимодействия энтекавира с другими препаратами, выводящимися почками или влияющими на функцию почек, не изучены. За пациентами должно проводиться тщательное медицинское наблюдение при одновременном назначении энтекавира с такими препаратами."},{"name":"Регистрационный номер","value":"ЛСР-000035"},{"name":"Дата государственной регистрации","value":"22.07.2021"},{"name":"Владелец регистрационного удостоверения","value":"Bristol-Myers Squibb"},{"name":"Изготовитель","value":"Bristol-Myers Squibb"},{"name":"Фасовщик","value":"Bristol-Myers Squibb"},{"name":"Страна бренда","value":"США"},{"name":"Страна-производитель","value":"США"},{"name":"Название препарата","value":"Бараклюд"},{"name":"Срок годности","value":"36 мес."}]}],"transitionId":"tr_1438659364415766755"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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    Цена 11 679 ₽
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  • Виферон супп. рект., 500000 МЕ, 10 шт.
    –15 %
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    Виферон супп. рект., 500000 МЕ, 10 шт.

    Рейтинг товара: 4.9 из 5
    на основе 197 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 491 ₽ вместо 496
    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  • Вобэнзим таб. п/о кш/раств., 40 шт.
    –1 %
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    Вобэнзим таб. п/о кш/раств., 40 шт.

    Рейтинг товара: 4.8 из 5
    на основе 248 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 713 ₽ вместо 720
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  • Циклоферон таб. п/о кш/раств., 150 мг, 50 шт.
    –1 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-zfcalww4xu/toggleWishlist":{"skuId":"101978088049","productId":1827567301,"offerId":"T8VVya3OAaKOlI0Vt6sBug","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQgaSLvveCuqBiEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIxe255wYQ8cT48vsCGJTU0Acg8tzBBw==","sign":"5spGlJWiwBtUnVkt1H8YAN0K2TGz/K99v42QofILcqg="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-zfcalww4xu/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Циклоферон таб. п/о кш/раств., 150 мг, 50 шт.

    Рейтинг товара: 4.9 из 5
    на основе 13 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 142 ₽ вместо 1 154
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  • Гриппферон капли наз. фл.-капельница, 10000 МЕ/мл, 10 мл
    –18 %
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    Гриппферон капли наз. фл.-капельница, 10000 МЕ/мл, 10 мл

    Рейтинг товара: 4.8 из 5
    на основе 190 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 312 ₽ вместо 315
    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  • Исмиген таб. подъязычн., 7 мг, 10 шт.
    –1 %
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    Исмиген таб. подъязычн., 7 мг, 10 шт.

    Рейтинг товара: 4.4 из 5
    на основе 5 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 731 ₽ вместо 738
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Инструкция

Показания к применению

Хронический гепатит В у взрослых с:
- компенсированным поражением печени и наличием вирусной репликации, повышения уровня активности сывороточных трансаминаз (аланинаминотрансфераза, АЛТ; или аспартатаминотрансфераза, ACT) и гистологических признаков воспалительного процесса в печени и/или фиброза,
- декомпенсированным поражением печени.

Противопоказания

- повышенная чувствительность к энтекавиру или любому другому компоненту препарата;
- детский возраст до 18 лет (эффективность и безопасность не изучены);
- редкая наследственная непереносимость лактозы, дефицит лактазы или глюкозо-галактозная мальабсорбция.

Способ применения и дозы

Энтекавир следует принимать внутрь натощак (то есть, не менее чем через 2 часа после еды и не позднее, чем за 2 часа до следующего приема пищи).
Рекомендуемая доза энтекавира для пациентов с компенсированным поражением печени составляет 0,5 мг один раз в день.
Резистентным к ламивудину пациентам (то есть, пациентам в анамнезе с виремией вирусом гепатита В, сохраняющейся на фоне терапии ламивудином, или пациентам с подтвержденной резистентностью к ламивудину) рекомендуется назначать 1 мг энтекавира один раз в день. Пациентам с декомпенсированным поражением печени рекомендуется назначать 1 мг энтекавира один раз в день.
Пациенты с почечной недостаточностью. Клиренс энтекавира уменьшается при снижении клиренса креатинина. Рекомендуется коррекция дозы энтекавира пациентам с клиренсом креатинина <50 мл/мин, в том числе находящимся на гемодиализе и длительном амбулаторном перитонеальном диализе.
Полная инструкция
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Бараклюд таб. п/о плен.
Бараклюд таб. п/о плен., 0.5 мг, 30 шт.
У продавца: 
нет • На Маркете: 4.9
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Инструкция

8 411 ₽

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    Таблетница на 7 дней / органайзер / бокс / контейнер на неделю для хранения таблеток и лекарств 4 приема Clear Daswerk

    Цена 418 ₽ вместо 637
  • Таблетница - брелок на день, 1 раздел, контейнер для таблеток металлический маленький (черный матовый)
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    Таблетница - брелок на день, 1 раздел, контейнер для таблеток металлический маленький (черный матовый)

    Цена 235 ₽ вместо 599
  • Таблетница из 14 секций на семь дней Утро-вечер
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    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1883422910_4/content/content/toggleWishlist":{"skuId":"102066600726","productId":1883422910,"offerId":"MF1mPo1TjMmUyA9JACu0Ng","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQgaSLvveCuqBiEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCL6Bi4IHEJb2kp38AhicnfkEIM3OPQ==","sign":"U0trmibTlTw7fuP8kjsoq/8MZOqiRzIcBhX/fnLPVPo="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1883422910_4/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Таблетница из 14 секций на семь дней Утро-вечер

    Цена 167 ₽ вместо 200
  • Виферон супп. рект., 500000 МЕ, 10 шт.
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    Виферон супп. рект., 500000 МЕ, 10 шт.

    Цена 491 ₽ вместо 580
  • Вобэнзим таб. п/о кш/раств., 40 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:228042487_6/content/content/gallery":{"title":"Вобэнзим таб. п/о кш/раств., 40 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4012265/img_id6128848204953117944.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4012265/img_id6128848204953117944.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id6128848204953117944.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id6128848204953117944.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id6128848204953117944.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id6128848204953117944.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4448948/img_id3687403674777473506.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4448948/img_id3687403674777473506.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4448948/img_id3687403674777473506.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4448948/img_id3687403674777473506.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4448948/img_id3687403674777473506.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4448948/img_id3687403674777473506.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/10141272/img_id7477845280144944207.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/10141272/img_id7477845280144944207.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/10141272/img_id7477845280144944207.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/10141272/img_id7477845280144944207.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/10141272/img_id7477845280144944207.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/10141272/img_id7477845280144944207.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQgaSLvveCuqBiEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCPfN3mwQ6PG9rfkCGJTh0Acg8tzBBw==","sign":"++lCbXWPVdF05YPvMiap6civxv7+cUepG85D0AKUPNc="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:228042487_6/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Вобэнзим таб. п/о кш/раств., 40 шт.

    Цена 713 ₽ вместо 720
  • Таблетница органайзер на неделю утро / день / вечер; Органайзер для таблеток на 7 дней; Карманная аптечка
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1901265275_7/content/content/gallery":{"title":"Таблетница органайзер на неделю утро / день / вечер; Органайзер для таблеток на 7 дней; Карманная аптечка","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4580925/img_id324533282421137844.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4580925/img_id324533282421137844.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4580925/img_id324533282421137844.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4580925/img_id324533282421137844.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4580925/img_id324533282421137844.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4580925/img_id324533282421137844.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/1581127/img_id4914961834506080269.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/1581127/img_id4914961834506080269.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/1581127/img_id4914961834506080269.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/1581127/img_id4914961834506080269.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/1581127/img_id4914961834506080269.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/1581127/img_id4914961834506080269.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4012150/img_id7503799791064630112.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4012150/img_id7503799791064630112.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4012150/img_id7503799791064630112.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4012150/img_id7503799791064630112.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4012150/img_id7503799791064630112.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4012150/img_id7503799791064630112.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/3934197/img_id4951263920939133144.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/3934197/img_id4951263920939133144.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/3934197/img_id4951263920939133144.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/3934197/img_id4951263920939133144.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/3934197/img_id4951263920939133144.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/3934197/img_id4951263920939133144.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/466729/img_id5124309738158613923.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/466729/img_id5124309738158613923.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/466729/img_id5124309738158613923.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/466729/img_id5124309738158613923.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/466729/img_id5124309738158613923.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/466729/img_id5124309738158613923.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQgaSLvveCuqBiEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCPuCzIoHEL2p9LP8AhiV/r8HIM3OPQ==","sign":"ShPedtLn+ckwIQt0m8i3P13Vx6JXS5oZymGOnZU7YMM="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1901265275_7/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Таблетница органайзер на неделю утро / день / вечер; Органайзер для таблеток на 7 дней; Карманная аптечка

    Цена 773 ₽ вместо 1 890
  • Реклама
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  • Таблетница компактная /органайзер аптечка/ контейнер для таблеток БАД Panda_Home (синего цвета)
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    Таблетница компактная /органайзер аптечка/ контейнер для таблеток БАД Panda_Home (синего цвета)

    Цена 245 ₽ вместо 263
  • Циклоферон таб. п/о кш/раств., 150 мг, 50 шт.
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    Циклоферон таб. п/о кш/раств., 150 мг, 50 шт.

    Цена 1 142 ₽ вместо 1 154
  • VETTA / Таблетница-органайзер для таблеток аптечка для лекарств карманная в дорогу с разделителем на 14 секций, на неделю 7 дней, утро вечер
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    VETTA / Таблетница-органайзер для таблеток аптечка для лекарств карманная в дорогу с разделителем на 14 секций, на неделю 7 дней, утро вечер

    Цена 331 ₽ вместо 950
  • Гриппферон капли наз. фл.-капельница, 10000 МЕ/мл, 10 мл
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    Гриппферон капли наз. фл.-капельница, 10000 МЕ/мл, 10 мл

    Цена 312 ₽ вместо 381
  • Исмиген таб. подъязычн., 7 мг, 10 шт.
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    Исмиген таб. подъязычн., 7 мг, 10 шт.

    Цена 731 ₽ вместо 738
  • Таблетница пенал - органайзер ABORNS на неделю 7 ячеек 7 дней
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    Таблетница пенал - органайзер ABORNS на неделю 7 ячеек 7 дней

    Цена 206 ₽ вместо 350
  • Таблетница пилюля С делителем
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    Таблетница пилюля С делителем

    Цена 461 ₽ вместо 665
  • Контейнер для хранения/таблетница/кейс для таблеток
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    Контейнер для хранения/таблетница/кейс для таблеток

    Цена 365 ₽ вместо 699
  • Таблетница пенал - органайзер ABORNS на неделю 7 ячеек 7 дней
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    Таблетница пенал - органайзер ABORNS на неделю 7 ячеек 7 дней

    Цена 176 ₽ вместо 400
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