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При круглогодичном (персистирующем) аллергическом рините (при наличии симптомов продолжительностью более 4 дней в неделю или более 4 недель в году) препарат следует принимать в течение всего периода экспозиции аллергена."},{"description":"","filters":[{"id":15767998,"name":"Побочные действия"}],"isMainProperty":false,"name":"Побочные действия","value":"Наиболее часто встречающиеся нежелательные эффекты (≥1/100 до \u003C1/10): повышенная утомляемость (в 1,2 % случаев), сухость во рту (0,8 %) и головная боль (0,6 %).\u003Cbr\u003EОчень редко (\u003C 1/10000) отмечались следующие нежелательные эффекты:\u003Cbr\u003E- со стороны нервной системы: галлюцинации, головокружение, сонливость, бессонница, психомоторная гиперактивность, судороги;\u003Cbr\u003E- со стороны печени и желчевыводящих путей: повышение активности ферментов печени, повышение концентрации билирубина, гепатит;\u003Cbr\u003E- со стороны пищеварительной системы: боль в животе, тошнота, рвота, диспепсия, диарея;\u003Cbr\u003E- со стороны сердечно-сосудистой системы: тахикардия, сердцебиение;\u003Cbr\u003E- со стороны опорно-двигательного аппарата: миалгия;\u003Cbr\u003E- аллергические реакции: анафилаксия, ангионевротический отек, одышка, зуд, сыпь, в том числе крапивница;\u003Cbr\u003E- со стороны кожи и подкожных тканей: фотосенсибилизация.\u003Cbr\u003EЧастота неизвестна: удлинение интервала QT, желтуха, астения.\u003Cbr\u003EПострегистрационный период.\u003Cbr\u003EДети: частота неизвестна - удлинение интервала QT, аритмия, брадикардия."},{"description":"","filters":[{"id":15768001,"name":"Фармакологическое действие"}],"isMainProperty":false,"name":"Фармакологическое действие","value":"Антигистаминный препарат длительного действия, H1-гистаминовых периферических рецепторов блокатор. Дезлоратадин является первичным активным метаболитом лоратадина. Ингибирует каскад реакций аллергического воспаления, в том числе высвобождение провоспалительных цитокинов, включая интерлейкины ИЛ-4, ИЛ-6, ИЛ-8, ИЛ-13, высвобождение провоспалительных хемокинов, продукцию супероксидных анионов активированными полиморфноядерными нейтрофилами, адгезию и хемотаксис эозинофилов, выделение молекул адгезии, таких как Р-селектин, lgE-опосредованное высвобождение гистамина, простагландина D2 и лейкотриена С4. Таким образом, предупреждает развитие и облегчает течение аллергических реакций, обладает противозудным и противоэкссудативным действием, уменьшает проницаемость капилляров, предупреждает развитие отека тканей, спазма гладкой мускулатуры. Препарат не оказывает воздействия на центральную нервную систему (ЦНС), практически не обладает седативным эффектом (не вызывает сонливости) и не влияет на скорость психомоторных реакций, не вызывает удлинения интервала QT на электрокардиограмме (ЭКГ)."},{"description":"","filters":[{"id":34045110,"name":"Фармакологическая группа"}],"isMainProperty":false,"name":"Фармакологическая группа","value":"H1-антигистаминные средства"},{"description":"","filters":[{"id":27141511,"name":"Форма выпуска для карточки"}],"isMainProperty":false,"name":"Форма выпуска","value":"таблетки"},{"description":"","filters":[{"id":35947170,"name":"Способ применения/введения"}],"isMainProperty":false,"name":"Способ применения/введения","value":"пероральный"},{"description":"","filters":[{"id":23679511,"name":"Минимальный возраст применения"},{"id":16082123,"name":"С рождения"}],"isMainProperty":false,"name":"Минимальный возраст применения","value":"от 12 лет"}]},{"name":"Дополнительно","specs":[{"description":"","filters":[{"id":15767999,"name":"Условия хранения"}],"isMainProperty":false,"name":"Условия хранения","value":"При температуре не выше 25 °С. Хранить в недоступном для детей месте."},{"description":"","filters":[{"id":15768014,"name":"Передозировка"}],"isMainProperty":false,"name":"Передозировка","value":"Симптомы: прием дозы, превышающей рекомендованную в 5 раз, не приводил к появлению каких-либо симптомов.\u003Cbr\u003EВ ходе клинических исследований ежедневное применение у взрослых и подростков дезлоратадина в дозе до 20 мг в течение 14 дней не сопровождалось статистически или клинически значимыми изменениями со стороны сердечно-сосудистой системы. В клинико-фармакологическом исследовании применение дезлоратадина в дозе 45 мг в сутки (в 9 раз выше рекомендуемой дозы) в течение 10 дней не вызывало удлинения интервала QT и не сопровождалось появлением серьезных побочных эффектов.\u003Cbr\u003EЛечение: промывание желудка, прием активированного угля, при необходимости - симптоматическая терапия. Дезлоратадин не выводится при гемодиализе, эффективность перитонеального диализа не установлена. При случайном приеме внутрь большого количества препарата необходимо незамедлительно обратиться к врачу."},{"description":"","filters":[{"id":15768015,"name":"Применение при беременности и кормлении грудью"}],"isMainProperty":false,"name":"Применение при беременности и кормлении грудью","value":"Применение дезлоратадина противопоказано при беременности и в период грудного вскармливания (недостаточно данных об эффективности и безопасности)."},{"description":"","filters":[{"id":17360993,"name":"Влияние на способность управлять транспортом и механизмами"}],"isMainProperty":false,"name":"Влияние на способность управлять транспортом и механизмами","value":"Влияние на способность управлять трансп. ср. и мех.: следует принимать во внимание потенциальную возможность развития таких побочных явлений, как головокружение и сонливость. При появлении описанных нежелательных явлений следует воздержаться от выполнения указанных видов деятельности."},{"description":"","filters":[{"id":15768012,"name":"Взаимодействие"}],"isMainProperty":false,"name":"Взаимодействие","value":"Не выявлено клинически значимых взаимодействий в исследованиях при совместном применении с азитромицином, кетоконазолом, эритромицином, флуоксетином и циметидином. Одновременный прием пищи или употребление грейпфрутового сока не оказывает влияния на эффективность препарата. Дезлоратадин не усиливает действие алкоголя на центральную нервную систему. Тем не менее, во время пострегистрационного применения были зарегистрированы случаи непереносимости алкоголя и алкогольного опьянения. 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Товар на Маркете
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Фотографии и видео покупателей
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Отличное средство, действует быстро, не вызывает сонливости
6 месяцев назад
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