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Описание

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Дифферин гель, 0,1%, 30 г

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4.8
(21)
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Коротко о товаре

Артикул Маркета
2228042570
Тип препарата
Назначение
Действующее вещество
Возраст
от 12 лет
Инструкция
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Данный механизм регулирует финальную дифференцировку кератиноцитов, что обеспечивает нормализацию процесса кератинизации и уменьшение предпосылок для формирования микрокомедонов.\u003Cbr\u003EДоказан выраженный противовоспалительный эффект адапалена: ингибирование липооксигеназы, арихидоновой кислоты, цитокинов. In vitro и in vivo проявляет высокую противовоспалительную активность, сравнимую по силе действия с бетаметазоном и индометацином, посредством влияния на факторы воспаления.\u003Cbr\u003EАдапален не обладает фотосенсибилизирующим действием."},{"name":"Фармакологическая группа","value":"средство лечения угревой сыпи"},{"name":"Форма выпуска","value":"гель"},{"name":"Способ применения/введения","value":"наружный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["35947170:36763741"]}}},{"name":"Минимальный возраст применения","value":"от 12 лет"},{"name":"Условия хранения","value":"Адапален - активное вещество препарата Дифферин, устойчив к кислороду и свету, химически неактивен.\u003Cbr\u003EГель следует хранить при температуре не выше 25°C, в недоступном для детей месте. Срок годности - 3 года.\u003Cbr\u003EКрем следует хранить при температуре не выше 25°C, в недоступном для детей месте; не замораживать. Срок годности - 2 года.\u003Cbr\u003EУсловия отпуска из аптек\u003Cbr\u003EПрепарат разрешен к применению в качестве средства безрецептурного отпуска."},{"name":"Передозировка","value":"Избыточное нанесение препарата на кожу не приведет к более быстрому достижению результата или получению более выраженного эффекта, однако при этом может развиться покраснение, шелушение или дискомфорт.\u003Cbr\u003E\nГель Дифферин предназначен только для наружного применения. При случайном проглатывании даже незначительного количества препарата, следует промыть желудок, при необходимости проводят симптоматическую терапию."},{"name":"Применение при беременности и кормлении грудью","value":"Беременность\u003Cbr\u003E\nКлинический опыт наружного применения адапалена при беременности носит ограниченный характер, однако доступные данные у пациенток, получавших препарат на ранних сроках беременности, не свидетельствуют о его отрицательном влиянии на течение беременности или на здоровье плода.\u003Cbr\u003E\nВ связи с ограниченными характером имеющихся данных, а также вследствие возможности незначительного проникновения адапалена через кожу, препарат Дифферин не следует применять во время беременности.\u003Cbr\u003E\nВ случае наступления беременности лечение следует прекратить.\u003Cbr\u003E\nПериод грудного вскармливания\u003Cbr\u003E\nИсследований проникновения препарата в грудное молоко животных или человека после нанесения на кожу не проводилось.\u003Cbr\u003E\nПоскольку системная экспозиция препарата Дифферин у кормящих грудью женщин незначительна, не предполагается какого-либо воздействия на детей, находящихся на грудном вскармливании. Препарат Дифферин можно применять в период грудного вскармливания.\u003Cbr\u003E\nВо избежание контакта грудного ребенка с препаратом при применении препарата Дифферин в период грудного вскармливания следует избегать нанесения на область груди."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Гель Дифферин не оказывает влияния на способность к управлению транспортными средствами и работе с механизмами."},{"name":"Особые указания","value":"При подозрении на развитие реакции повышенной чувствительности или тяжелой формы раздражения кожи следует прекратить применение препарата.\u003Cbr\u003E\nВ некоторых случаях, в зависимости от степени раздражения кожи, число нанесений может быть сокращено или лечение приостановлено до исчезновения признаков раздражения. Возобновление лечения возможно после консультации с врачом.\u003Cbr\u003E\nСледует избегать попадания крема в глаза, рот, уголки носа и на слизистые оболочки.\u003Cbr\u003E\nПри случайном попадании препарата на слизистые оболочки глаз, необходимо промыть их теплой водой.\u003Cbr\u003E\nПрепарат нельзя наносить на поврежденную в результате травмы (порезы или ссадины), солнечного ожога или экзематозную кожу.\u003Cbr\u003E\nДля лечения узловатых и конглобатных акне тяжелой степени применяют системные антибактериальные препараты + адапален, бензоила пероксид или комбинацию адапален + бензоила пероксид. В этом случае адапален может применяться для лечения угревой сыпи на лице, груди или спине под наблюдением врача.\u003Cbr\u003E\nОднако не следует применять адапален в монотерапии у пациентов с тяжелой формой угревой сыпи на обширных участках кожи. Препарат в виде крема лучше подходит для применения на сухой и светлой коже.\u003Cbr\u003E\nВо избежание раздражения кожи при применении адапалена необходимо свести к минимуму воздействие солнечного света и искусственного ультрафиолетового облучения, включая лампы солнечного света. Если избежать такого воздействия не представляется возможным, рекомендуется применение солнцезащитных средств и одежды для защиты участков кожи, на которые был нанесен препарат.\u003Cbr\u003E\nПри применении препарата Дифферин возможно использование косметических средств, не обладающих комедогенными или вяжущими свойствами.\u003Cbr\u003E\nКрем Дифферин содержит метилпарагидроксибензоат (E218) и пропилпарагидроксибензоат (Е216), которые могут вызывать аллергические реакции во время или после завершения лечения."},{"name":"Взаимодействие","value":"Всасывание адапалена через кожу является низким, поэтому его взаимодействие с системными лекарственными препаратами маловероятно.\u003Cbr\u003E\nНе установлено взаимодействий с другими лекарственными средствами, которые могут применяться наружно и одновременно с препаратом Дифферин. При применении геля Дифферин в вечернее время, утром можно применять такие препараты для наружного лечения угревой сыпи, как растворы эритромицина (до 4%) или клиндамицина фосфата (1% в пересчете на основание) или гели бензоила пероксида на водной основе (до 10%) поскольку данные препараты не вызывают взаимной деградации или кумулятивного раздражения. Тем не менее, одновременно с адапаленом не следует применять другие ретиноиды или препараты со сходным механизмом действия.\u003Cbr\u003E\nОдновременное применение препарата Дифферин и средств для пилинга, абразивных очищающих средств, а также средств с подсушивающим, вяжущим или раздражающим действием (ароматических или спиртсодержащих средств) не рекомендуется."},{"name":"Регистрационный номер","value":"П N012654/01"},{"name":"Дата государственной регистрации","value":"02.09.2020"},{"name":"Владелец регистрационного удостоверения","value":"Laboratoires GALDERMA","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["34324371:35649313","7893318:35767891"]}}},{"name":"Изготовитель","value":"Galderma"},{"name":"Фасовщик","value":"Galderma"},{"name":"Страна бренда","value":"Франция"},{"name":"Страна-производитель","value":"Франция"},{"name":"Название препарата","value":"Дифферин","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["17796364:17879641"]}}},{"name":"Срок годности","value":"36 мес."}]}},"fullSpecsGrouped":{"15459665099371304449":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Органы и системы","value":"кожа"},{"name":"Назначение","value":"угревая болезнь"},{"name":"Показания к применению","value":"Угревая сыпь легкой и средней степени тяжести, в том числе при наличии комедонов, папул и пустул."},{"name":"Противопоказания","value":"Повышенная чувствительность к адапалену или любому из вспомогательных веществ;\u003Cbr\u003E\nДетский возраст до 12 лет (эффективность и безопасность препарата для данной возрастной категории не установлена)."},{"name":"Состав","value":"Действующее вещество: адапален – 1 мг\u003Cbr\u003EВспомогательные вещества: пропиленгликоль – 40 мг, метилпарагидроксибензоат – 1 мг, феноксиэтанол – 2.5 мг, карбомер 940 P – 11 мг, динатрия эдетат – 1 мг, полоксамер 182 – 2 мг, натрия гидроксид – до pH 5.0±0.15, вода очищенная – до 1 г\u003Cbr/\u003E"},{"name":"Действующее вещество","value":"Адапален"},{"name":"Способ применения и дозы","value":"Крем или гель равномерно, не втирая, наносят на пораженные участки кожи 1 раз/сут перед сном. Препарат следует наносить на чистую, сухую кожу.\u003Cbr\u003EТерапевтический эффект развивается после 4-8 недель терапии, стойкое улучшение - через 3 месяца с начала терапии.\u003Cbr\u003EВозможно проведение повторных курсов терапии препаратом по рекомендации врача.\u003Cbr\u003EДифферин крем рекомендован для чувствительной и сухой кожи.\u003Cbr\u003EДифферин показан для лечения акне легкой и средней степени тяжести в качестве монотерапии, а при акне средней степени тяжести также в комбинации с другими местными (антибиотики, бензоил пероксид) и системными (антибиотики, антиандрогены для приема внутрь) препаратами."},{"name":"Побочные действия","value":"При применении препарата Дифферин, крем для наружного применения, могут возникать нежелательные реакции, указанные в таблице ниже, которые распределены по классам систем органов и частоте встречаемости с использованием следующей принятой классификации: очень часто (≥ 1/10), часто (от ≥ 1/100 до \u003C 1/10), нечасто (от ≥ 1/1000 до \u003C 1/100), редко (от ≥ 1/10 000 до \u003C 1/1000), очень редко (\u003C 1/10 000), частота неизвестна (частота встречаемости не может быть определена на основании имеющихся данных, включая данные пострегистрационного применения).\u003Cbr\u003E\nНарушения со стороны иммунной системы - Частота неизвестна - Анафилактическая реакция, ангионевротический отек.\u003Cbr\u003E\nНарушения со стороны органа зрения - Частота неизвестна - Раздражение кожи век, эритема кожи век, зуд век, отек век.\u003Cbr\u003E\nНарушения со стороны кожи и подкожных тканей - Часто - Сухость кожи, раздражение кожи, ощущение жжения кожи, эритема,\u003Cbr\u003E\nНечасто - Контактный дерматит, ощущение дискомфорта, солнечный ожог, зуд, шелушение кожи, угревая сыпь,\u003Cbr\u003E\nЧастота неизвестна - Аллергический дерматит, аллергический контактный дерматит), болезненность кожи, отек кожи, ожог в месте нанесения, гипопигментация кожи, гиперпигменация кожи. Если любые из указанных в инструкции побочных эффектов усугубляются или отмечаются любые другие побочные эффекты, не указанные в инструкции, следует немедленно сообщить об этом врачу."},{"name":"Фармакологическое действие","value":"Адапален представляет новое поколение синтетических ретиноидов и является производным нафтойной кислоты. Адапален обладает себостатическим, комедонолитическим/антикомедогенным и противовоспалительным действием.\u003Cbr\u003EПрепарат воздействует на фолликулярный гиперкератоз, регулируя процесс кератинизации и десквамации - обладает выраженной комедонолитической активностью (воздействует на открытые и закрытые комедоны) и антикомедогенным действием (предотвращает образование микрокомедонов).\u003Cbr\u003EОсновной механизм действия - селективное связывание с ядерными RAγ-рецепторами клеток эпидермиса в отличии от неизбирательного связывания ретиноидов предшествующих поколений. Данный механизм регулирует финальную дифференцировку кератиноцитов, что обеспечивает нормализацию процесса кератинизации и уменьшение предпосылок для формирования микрокомедонов.\u003Cbr\u003EДоказан выраженный противовоспалительный эффект адапалена: ингибирование липооксигеназы, арихидоновой кислоты, цитокинов. In vitro и in vivo проявляет высокую противовоспалительную активность, сравнимую по силе действия с бетаметазоном и индометацином, посредством влияния на факторы воспаления.\u003Cbr\u003EАдапален не обладает фотосенсибилизирующим действием."},{"name":"Фармакологическая группа","value":"средство лечения угревой сыпи"},{"name":"Форма выпуска","value":"гель"},{"name":"Способ применения/введения","value":"наружный"},{"name":"Минимальный возраст применения","value":"от 12 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Адапален - активное вещество препарата Дифферин, устойчив к кислороду и свету, химически неактивен.\u003Cbr\u003EГель следует хранить при температуре не выше 25°C, в недоступном для детей месте. Срок годности - 3 года.\u003Cbr\u003EКрем следует хранить при температуре не выше 25°C, в недоступном для детей месте; не замораживать. Срок годности - 2 года.\u003Cbr\u003EУсловия отпуска из аптек\u003Cbr\u003EПрепарат разрешен к применению в качестве средства безрецептурного отпуска."},{"name":"Передозировка","value":"Избыточное нанесение препарата на кожу не приведет к более быстрому достижению результата или получению более выраженного эффекта, однако при этом может развиться покраснение, шелушение или дискомфорт.\u003Cbr\u003E\nГель Дифферин предназначен только для наружного применения. При случайном проглатывании даже незначительного количества препарата, следует промыть желудок, при необходимости проводят симптоматическую терапию."},{"name":"Применение при беременности и кормлении грудью","value":"Беременность\u003Cbr\u003E\nКлинический опыт наружного применения адапалена при беременности носит ограниченный характер, однако доступные данные у пациенток, получавших препарат на ранних сроках беременности, не свидетельствуют о его отрицательном влиянии на течение беременности или на здоровье плода.\u003Cbr\u003E\nВ связи с ограниченными характером имеющихся данных, а также вследствие возможности незначительного проникновения адапалена через кожу, препарат Дифферин не следует применять во время беременности.\u003Cbr\u003E\nВ случае наступления беременности лечение следует прекратить.\u003Cbr\u003E\nПериод грудного вскармливания\u003Cbr\u003E\nИсследований проникновения препарата в грудное молоко животных или человека после нанесения на кожу не проводилось.\u003Cbr\u003E\nПоскольку системная экспозиция препарата Дифферин у кормящих грудью женщин незначительна, не предполагается какого-либо воздействия на детей, находящихся на грудном вскармливании. Препарат Дифферин можно применять в период грудного вскармливания.\u003Cbr\u003E\nВо избежание контакта грудного ребенка с препаратом при применении препарата Дифферин в период грудного вскармливания следует избегать нанесения на область груди."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Гель Дифферин не оказывает влияния на способность к управлению транспортными средствами и работе с механизмами."},{"name":"Особые указания","value":"При подозрении на развитие реакции повышенной чувствительности или тяжелой формы раздражения кожи следует прекратить применение препарата.\u003Cbr\u003E\nВ некоторых случаях, в зависимости от степени раздражения кожи, число нанесений может быть сокращено или лечение приостановлено до исчезновения признаков раздражения. Возобновление лечения возможно после консультации с врачом.\u003Cbr\u003E\nСледует избегать попадания крема в глаза, рот, уголки носа и на слизистые оболочки.\u003Cbr\u003E\nПри случайном попадании препарата на слизистые оболочки глаз, необходимо промыть их теплой водой.\u003Cbr\u003E\nПрепарат нельзя наносить на поврежденную в результате травмы (порезы или ссадины), солнечного ожога или экзематозную кожу.\u003Cbr\u003E\nДля лечения узловатых и конглобатных акне тяжелой степени применяют системные антибактериальные препараты + адапален, бензоила пероксид или комбинацию адапален + бензоила пероксид. В этом случае адапален может применяться для лечения угревой сыпи на лице, груди или спине под наблюдением врача.\u003Cbr\u003E\nОднако не следует применять адапален в монотерапии у пациентов с тяжелой формой угревой сыпи на обширных участках кожи. Препарат в виде крема лучше подходит для применения на сухой и светлой коже.\u003Cbr\u003E\nВо избежание раздражения кожи при применении адапалена необходимо свести к минимуму воздействие солнечного света и искусственного ультрафиолетового облучения, включая лампы солнечного света. Если избежать такого воздействия не представляется возможным, рекомендуется применение солнцезащитных средств и одежды для защиты участков кожи, на которые был нанесен препарат.\u003Cbr\u003E\nПри применении препарата Дифферин возможно использование косметических средств, не обладающих комедогенными или вяжущими свойствами.\u003Cbr\u003E\nКрем Дифферин содержит метилпарагидроксибензоат (E218) и пропилпарагидроксибензоат (Е216), которые могут вызывать аллергические реакции во время или после завершения лечения."},{"name":"Взаимодействие","value":"Всасывание адапалена через кожу является низким, поэтому его взаимодействие с системными лекарственными препаратами маловероятно.\u003Cbr\u003E\nНе установлено взаимодействий с другими лекарственными средствами, которые могут применяться наружно и одновременно с препаратом Дифферин. При применении геля Дифферин в вечернее время, утром можно применять такие препараты для наружного лечения угревой сыпи, как растворы эритромицина (до 4%) или клиндамицина фосфата (1% в пересчете на основание) или гели бензоила пероксида на водной основе (до 10%) поскольку данные препараты не вызывают взаимной деградации или кумулятивного раздражения. Тем не менее, одновременно с адапаленом не следует применять другие ретиноиды или препараты со сходным механизмом действия.\u003Cbr\u003E\nОдновременное применение препарата Дифферин и средств для пилинга, абразивных очищающих средств, а также средств с подсушивающим, вяжущим или раздражающим действием (ароматических или спиртсодержащих средств) не рекомендуется."},{"name":"Регистрационный номер","value":"П N012654/01"},{"name":"Дата государственной регистрации","value":"02.09.2020"},{"name":"Владелец регистрационного удостоверения","value":"Laboratoires GALDERMA"},{"name":"Изготовитель","value":"Galderma"},{"name":"Фасовщик","value":"Galderma"},{"name":"Страна бренда","value":"Франция"},{"name":"Страна-производитель","value":"Франция"},{"name":"Название препарата","value":"Дифферин"},{"name":"Срок годности","value":"36 мес."}]}],"transitionId":"tr_1012879600490246356"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом

Где купить

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Ещё может подойти

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Инструкция

Показания к применению

Угревая сыпь легкой и средней степени тяжести, в том числе при наличии комедонов, папул и пустул.

Противопоказания

Повышенная чувствительность к адапалену или любому из вспомогательных веществ;
Детский возраст до 12 лет (эффективность и безопасность препарата для данной возрастной категории не установлена).

Способ применения и дозы

Крем или гель равномерно, не втирая, наносят на пораженные участки кожи 1 раз/сут перед сном. Препарат следует наносить на чистую, сухую кожу.
Терапевтический эффект развивается после 4-8 недель терапии, стойкое улучшение - через 3 месяца с начала терапии.
Возможно проведение повторных курсов терапии препаратом по рекомендации врача.
Дифферин крем рекомендован для чувствительной и сухой кожи.
Дифферин показан для лечения акне легкой и средней степени тяжести в качестве монотерапии, а при акне средней степени тяжести также в комбинации с другими местными (антибиотики, бензоил пероксид) и системными (антибиотики, антиандрогены для приема внутрь) препаратами.
Полная инструкция
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Дифферин гель
Дифферин гель, 0,1%, 30 г
4.8
(21)
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2 вопроса
Инструкция
Нет в продаже
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4.8
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У продавца:21 оценка·6 отзывов
У всех продавцов:235 оценок·51 отзыв
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user avatar
3 месяца назад • Msgaudeo Khl • Куплен на Маркете
Достоинства: помогает от прыщей
Недостатки: дороговат
Комментарий: Купила дифферин (адапален), т.к. азелик 20% не помогает от прыщей дочери. Через три недели стало лучше.
user avatar
9 месяцев назад • Татьяна А. • Куплен на Маркете
Достоинства: С функцией своей справляется на все 100. За месяц использования кожа стала намного чище. Геля хватит надолго, расход экономичный.
user avatar
7 месяцев назад • Мария Валуева • Куплен на Маркете
Достоинства: уже не первый раз пользуюсь, хороший крем, но конечно надо потерпеть пока кожа к нему привыкнет
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    Жидкий пластырь Fixplast c пантенолом, 60 мл

    Цена 355 ₽ вместо 399
  • Дифферин крем, 0,1%, 30 мл, 30 г
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    Дифферин крем, 0,1%, 30 мл, 30 г

    Цена 1 328 ₽ вместо 1 341
  • Vitamin D3, 50000 МЕ, 50 мл, 50 шт.
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    Vitamin D3, 50000 МЕ, 50 мл, 50 шт.

    Цена 1 355 ₽ вместо 1 940
  • Solgar Zinc Picolinate таб., 170 г, 100 шт.
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    Solgar Zinc Picolinate таб., 170 г, 100 шт.

    Цена 1 277 ₽ вместо 1 677
  • Азелик гель д/нар. прим., 15%, 5 мл, 5 г
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    Азелик гель д/нар. прим., 15%, 5 мл, 5 г

    Цена 416 ₽ вместо 470
  • Клензит гель д/нар. прим., 15 г
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    Клензит гель д/нар. прим., 15 г

    Цена 753 ₽ вместо 761
  • NIVEA лосьон Увлажнение после загара, 200 мл.
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    NIVEA лосьон Увлажнение после загара, 200 мл.

    Цена 339 ₽ вместо 565
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    Реклама
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  • Клензит-C гель д/нар. прим., 15 г
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    Клензит-C гель д/нар. прим., 15 г

    Цена 1 052 ₽ вместо 1 063
  • Клиндовит гель д/нар. прим., 1%, 30 г
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    Клиндовит гель д/нар. прим., 1%, 30 г

    Цена 494 ₽ вместо 499
  • Адаклин крем д/нар. прим., 0,1%, 1 мл, 30 г
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    Адаклин крем д/нар. прим., 0,1%, 1 мл, 30 г

    Цена 940 ₽ вместо 949
  • Салфетка спиртовая (этиловый спирт) 60*100 мм 100 шт.
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    Салфетка спиртовая (этиловый спирт) 60*100 мм 100 шт.

    Цена 208 ₽ вместо 288
  • Вата стерильная хирургическая 100 г
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    Вата стерильная хирургическая 100 г

    Цена 173 ₽ вместо 198
  • Эффезел гель д/нар. прим., 1 мг/г+25 мг/г, 30 мл, 30 г, 1 шт.
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    Эффезел гель д/нар. прим., 1 мг/г+25 мг/г, 30 мл, 30 г, 1 шт.

    Цена 2 078 ₽
  • Скиноклир гель д/нар. прим. туба, 15%, 30 мл, 30 г
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    Скиноклир гель д/нар. прим. туба, 15%, 30 мл, 30 г

    Цена 763 ₽ вместо 771
  • Скиноклир крем д/нар.прим. туба, 20%, 30 г
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    Скиноклир крем д/нар.прим. туба, 20%, 30 г

    Цена 812 ₽ вместо 820
  • Гилан ультра комфорт увлажн. гл. р-р, 0.3%, 0.4 мл, 50 г, 10 шт.
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    Гилан ультра комфорт увлажн. гл. р-р, 0.3%, 0.4 мл, 50 г, 10 шт.

    Цена 288 ₽ вместо 331
  • Хронотрон имплантат инъекц. гель для в/суст. введ., 20 мг/мл, 2 мл, 1 шт.
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    Хронотрон имплантат инъекц. гель для в/суст. введ., 20 мг/мл, 2 мл, 1 шт.

    Цена 9 356 ₽ вместо 9 450
  • Ретинол пальмитат (вит а) р-р масляный, 1 шт.
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    Ретинол пальмитат (вит а) р-р масляный, 1 шт.

    Цена 141 ₽ вместо 142
  • Цинктерал-Тева таб. п/о плен., 25 шт.
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    Цинктерал-Тева таб. п/о плен., 25 шт.

    Цена 474 ₽ вместо 536
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    Реклама
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  • Розамет крем, 1%, 25 мл, 25 г
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    Розамет крем, 1%, 25 мл, 25 г

    Цена 359 ₽ вместо 363
  • БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.
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    БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.

    Цена 1 752 ₽ вместо 3 500
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