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Дутастерид-Тева капс., 0.5 мг, 90 шт.

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5.0
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Количество штук в упаковке, шт.: 90

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Коротко о товаре

Артикул Маркета
4453158119
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
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В основном изучалась комбинация дутастерида и a1-адреноблокатора тамсулозина."},{"name":"Противопоказания","value":"Препарат противопоказан пациентам с гиперчувствительностью к дутастериду или любому компоненту препарата и другим ингибиторам 5а-редуктазы. Применение препарата противопоказано женщинам и детям. Применение препарата противопоказано пациентам с тяжелыми нарушениями функции печени."},{"name":"Состав","value":"в 1 капсуле содержится:\u003Cbr\u003Eдействующее вещество дутастерид 0,500 мг;\u003Cbr\u003Eвспомогательные вещества: бутилгидрокситолуол (E32I) 0.035мг, глицерол монокаприлокапрат (тип I) 349,465 мг;\u003Cbr\u003Eоболочка капсулы: желатин 160,150 мг, глицерол (Е422) 95,329 мг, Opatint белый (G-18000) (глицерол (Е422) 3,812 мг, титана диоксид (Е171) 1,907 мг), Opatint желтый (G-12014) (глицерол (Е422) 0,642 мг, железа оксид желтый (Е172) 0.160 мг), триглицериды среднецепочечные (следовое количество)."},{"name":"Действующее вещество","value":"Дутастерид","transition":{"type":"catalog","params":{"categorySlug":"mochepolovaia-sistema-i-polovye-gormony","categoryId":"15756910","navnodeId":"72506","glfilters":["27144131:28710165"]}}},{"name":"Способ применения и дозы","value":"Внутрь один раз в сутки независимо от приема пищи.\u003Cbr\u003EКапсулы препарата Гардиум следует глотать целиком, не разжевывать, не открывать, поскольку содержимое капсулы может вызывать раздражение слизистой ротоглотки.\u003Cbr\u003EДоброкачественная гиперплазия предстательной железы Взрослые мужчины (включая пожилых)\u003Cbr\u003EРекомендуемая доза препарата Гардиум - одна капсула (0,5 мг) один раз в сутки перорально. Капсулы следует принимать целиком.\u003Cbr\u003EХотя улучшение на фоне применения препарата наступает довольно быстро, лечение следует продолжать не менее 6 месяцев для того, чтобы объективно оценить терапевтический эффект.\u003Cbr\u003EДля лечения ДГПЖ препарат Гардиум может быть назначен в качестве монотерапии или в комбинации с a1-адреноблокаторами.\u003Cbr\u003EОсобые группы пациентов Пациенты с нарушениями функции почек.\u003Cbr\u003EПри приеме 0,5 мг препарата в сутки почками выделяется менее 0,1% дозы, поэтому нет необходимости снижать дозу у пациентов с нарушениями функции почек.\u003Cbr\u003EПациенты с нарушениями функции печени.\u003Cbr\u003EВ настоящее время нет данных по применению препарата Гардиум у пациентов с нарушениями функции печени. Так как дутастерид подвергается интенсивному метаболизму, а его период полувыведения составляет 3-5 недель, необходимо соблюдать осторожность при лечении препаратом Гардиум пациентов с нарушениями функции печени."},{"name":"Побочные действия","value":"Применение дутастерида в качестве монотерапии\u003Cbr\u003EПеречисленные ниже нежелательные явления (НЯ) по данным контролируемых клинических исследований и данным постмаркетингового наблюдения - это отмеченные исследователями случаи, связанные с приемом препарата (с частотой возникновения, большей либо равной 1%), которые отмечались с более высокой частотой у пациентов, лечившихся дутастеридом в течение первого года лечения, по сравнению с пациентами, получавшими плацебо. НЯ по данным пострегистрационного опыта применения выявлены из случайно отобранных пострегистрационных отчетов: таким образом, реальная частота их возникновения неизвестна.\n\u003Cbr\u003EНЯ систематизированы в соответствии с Классификацией Всемирной организации здравоохранения (ВОЗ): очень часто (\u003E1/10), часто (\u003E1/100 и \u003C1/10), нечасто (\u003E1/1000 и \u003C1/100), редко (\u003E1/10000 и \u003C1/1000), очень редко (\u003C1/10000); неизвестно (невозможно определить на основе имеющихся данных).\u003Cbr\u003EНарушения со стороны репродуктивной системы и грудных желез:\u003Cbr\u003E-эректильная дисфункция(Частота возникновения в течение 1-го года лечения (п=2167) - 6%;Частота возникновения в течение 2-го года лечения (п=1744) - 1,7%)\u003Cbr\u003E-изменение (снижение)либидо(Частота возникновения в течение 1-го года лечения (п=2167) - 3,7%; Частота возникновения в течение 2-го года лечения (п=1744) - 0,6%)\u003Cbr\u003E-нарушения эякуляции*++(1,8%;0,5%)\u003Cbr\u003E-изменения грудных желез+(1,3%;1,3%)\u003Cbr\u003EЧастота возникновения оценивалась по пострегистрационным данным\u003Cbr\u003EНарушения со стороны иммунной системы:\u003Cbr\u003E-аллергические реакции, включая высыпания, зуд, крапивницу, локализованный отек и отек Квинке(неизвестно)\u003Cbr\u003EНарушения психики:\u003Cbr\u003E-депрессивное состояние(неизвестно)\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей:\u003Cbr\u003E-алопеция (в первую очередь, выпадение волос на теле), гипертрихоз(нечастно)\u003Cbr\u003EНарушения со стороны репродуктивной системы и молочных желез:\u003Cbr\u003E-тестикулярные боли и увеличение яичек(неизвестно)\u003Cbr\u003E*Данные НЯ в сексуальной сфере связаны с лечением дутастеридом(включая монотерапию и сочетание с тамсулозином). \u003Cbr\u003EДанные НЯ могут сохраняться и после прекращения лечения. Роль дутастерида в сохранении данного эффекта неизвестна\u003Cbr\u003EВключают болезненность и увеличение грудных желез + уменьшение объема спермы\u003Cbr\u003EПрименение дутастерида в комбинации с тамсулозином\u003Cbr\u003EРезультаты 4-лстнего исследования CombAT, сравнивающего дутастерид 0,5 мг (п=1623) и тамсулозина 0,4 мг (п=16 11) один раз в сутки в виде монотерапии или в комбинации, показали, что частота НЯ, оцененных исследователями как связанных с препаратом/комбинацией препаратов, в течении первого, второго, третьего и четвертого года исследования составляла соответственно 22%, 6%, 4% и 2% для комбинированной терапии дутастеридом/тамсулозином; 15%, 6%, 3% и 2% для монотерапии тамсулозином. Более высокая частота НЯ в группе комбинированной терапии в первый год лечения была связана с более высокой частотой репродуктивных расстройств, в частности нарушений эякуляции, наблюдаемых в этой группе.\u003Cbr\u003EСообщалось о следующих НЯ, оцененных исследователями как связанных с препаратом/комбинацией препаратов, встречающихся с частотой \u003E 1% в течении первого года лечения в исследовании CombAT: частота этих НЯ в течении четырех лет исследования представлена в таблице ниже:\u003Cbr\u003EКоличество пациентов (n) и частота (%) возникновения за период лечения\u003Cbr\u003EКомбинация1-1 год - п=1610, 2й год - п=1428, 3-й год - п=1238, 4й год - п=1200\u003Cbr\u003EДутастерид-(n=1623)-(n=1464)-(n=1325)-(n=1200)\u003Cbr\u003EТамсулозин-(n=1611)-(n=1468)-(n=1281)-(n=1112)\u003Cbr\u003EСо стороны нервной системы\n\u003Cbr\u003EГоловокружение\u003Cbr\u003EКомбинация-1.4%-0.1%-\u003C0.1%-0.2%\u003Cbr\u003EДутастерид-0.7%-0.1%-\u003C0.1%-\u003C0.1%\u003Cbr\u003EТамсулозин-1.3%-0.4%-\u003C0.1%-0%\u003Cbr\u003EСо стороны сердечно-сосудистой системы\u003Cbr\u003EСердечная недостаточность2\u003Cbr\u003EКомбинация-0.2%-0.4%-0.2%-0.2%\u003Cbr\u003EДутастерид-\u003C0.1%-0.1%-\u003C0.1%-0%\u003Cbr\u003EТамсулозин-0.1%-\u003C0.1%-0.4%-0.2%\u003Cbr\u003EСо стороны репродуктивной системы и грудной железы\u003Cbr\u003EЭректильная дисфункция3\u003Cbr\u003EКомбинация-6.3%-1.8%-0.9%-0.4%\u003Cbr\u003EДутастерид-5.1%-1.6%-0.6%-0.3%\u003Cbr\u003EТамсулозин-3.3%-1.0%-0.6%-1.1%\u003Cbr\u003EСнижение либидо3\u003Cbr\u003EКомбинация-5.3%-0.8%-0.2%-0%\u003Cbr\u003EДутастерид-3.8%-1.0%-0.2%-0%\u003Cbr\u003EТамсулозин-2.5%-0.7%-0.2%-\u003C0.1%\u003Cbr\u003EНарушения эякуляции3,5\u003Cbr\u003EКомбинация-9.0%-1.0%-0.5%-\u003C0.1%\u003Cbr\u003EДутастерид-1.5%-0.5%-0.2%-0.3%\u003Cbr\u003EТамсулозин-2.7%-0.5%-0.2%-0.3%\u003Cbr\u003EИзменения грудной железы4\u003Cbr\u003EКомбинация-2.1%-0.8%-0.9%-0.6%\u003Cbr\u003EДутастерид-1.7%-1.2%-0.5%-0.7%\u003Cbr\u003EТамсулозин-0.8%-0.4%-0.2%-0%\u003Cbr\u003E1 Комбинация = Дутастерид-Тева 0.5 мг 1 раз/сут + тамсулозин 0.4 мг 1 раз/сут;\u003Cbr\u003E2 Включая хроническую сердечную недостаточность, сердечную недостаточность, левожелудочковую недостаточность, острую сердечную недостаточность, кардиогенный шок, острую левожелудочковую недостаточность, правожелудочковую недостаточность, острую правожелудочковую недостаточность, желудочковую недостаточность, сердечно-легочную недостаточность, застойную кардиомиопатию;\u003Cbr\u003E3 НЯ со стороны репродуктивной системы и грудных желез, связанные с применением препарата Дутастерид-Тева (как при монотерапии, так и в комбинации с тамсулозином). Данные НЯ могут сохраняться после прекращения лечения и влияние препарата Дутастерид-Тева на сохранение данных НЯ неизвестно;\u003Cbr\u003E4 Включают болезненность и увеличение грудных желез;\u003Cbr\u003E5 Уменьшение объема спермы."},{"name":"Фармакологическое действие","value":"Максимальное влияние суточных доз дутастерида на снижение концентрации ДГТ является дозозависимым и наблюдается в течение 1-2 недель. Через 1 и 2 недели приема дутастерида в дозе 0.5 мг в сутки средние значения концентраций ДГТ в сыворотке крови снижались на 85% и 90% соответственно.\u003Cbr\u003EУ пациентов с доброкачественной гиперплазией предстательной железы (ДГПЖ), получавших 0.5 мг дутастерида в сутки, среднее снижение концентрации ДГТ составило 94% через 1 год и 93% через 2 года, среднее увеличение концентрации тестостерона в сыворотке крови составило 19% как через 1 год, так и через 2 года. Это является ожидаемым последствием ингибирования 5а-редуктазы и не приводит ни к одному из известных нежелательных явлений."},{"name":"Фармакологическая группа","value":"5-альфа редуктазы ингибитор"},{"name":"Форма выпуска","value":"капсулы"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"mochepolovaia-sistema-i-polovye-gormony","categoryId":"15756910","navnodeId":"72506","glfilters":["35947170:36763744"]}}},{"name":"Пол","value":"для мужчин","transition":{"type":"catalog","params":{"categorySlug":"mochepolovaia-sistema-i-polovye-gormony","categoryId":"15756910","navnodeId":"72506","glfilters":["14805991:14805992"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"Хранить при температуре не выше 25 °C, в оригинальной упаковке.\nХранить в недоступном для детей месте."},{"name":"Передозировка","value":"При применении дутастерида до 40 мг/день однократно (в 80 раз выше терапевтической дозы) в течение 7 дней значимых побочных эффектов не отмечалось.\nПри проведении клинических исследований пациенты в течение 6 месяцев получали дутастерид в дозе 5 мг ежедневно, при этом каких-либо дополнительных побочных эффектов к тем, что наблюдались на фоне приема 0.5 мг дутастерида. обнаружено не было. Специфического антидота дутастерида нет, поэтому при подозрении на передозировку достаточно проводить симптоматическое и поддерживающее лечение."},{"name":"Применение при беременности и кормлении грудью","value":"Беременность.\u003Cbr\u003EДутастерид противопоказан женщинам. Дутастерид не изучался у женщин, так как доклинические данные свидетельствуют о том, что подавление уровня ДГТ может вызывать торможение развития наружных половых органов у плода мужского пола.\u003Cbr\u003EГрудное вскармливание:\u003Cbr\u003Eнет данных о проникновении дутастерида в грудное молоко."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Прием дутастерида не влияет на способность управлять транспортными средствами и\nмеханизмами."},{"name":"Особые указания","value":"С осторожностью: печеночная недостаточность.\u003Cbr\u003EФертильность\u003Cbr\u003EВлияние дутастерида в суточной дозе 0,5 мг на характеристики спермы изучалось у здоровых добровольцев в возрасте 18-52 лет на протяжении 52 недель лечения и последующего 24 недельного наблюдения. К 52-й неделе лечения в группе пациентов, получавших дутастерид, средние значения процентного снижения общего количества сперматозоидов, объема спермы и двигательной активности сперматозоидов составляли 23%, 26% и 18% соответственно, по сравнению с исходным уровнем в группе пациентов, получавших плацебо. Концентрация сперматозоидов и их морфология не изменялись.\u003Cbr\u003EЧерез 24 недели последующего наблюдения среднее значение изменения общего количества сперматозоидов в группе дутастерида оставалось на 23% ниже по сравнению с исходным уровнем. В то время, как средние значения всех параметров спермы во всех временных точках оставались в пределах нормы и не соответствовали заданным критериям для клинически значимых изменений (30%), у двух добровольцев в группе дутастерида общее количество сперматозоидов на 52-ой неделе снижалось более чем на 90% по сравнению с исходным уровнем, с частичным восстановлением на 24-й неделе наблюдения. Таким образом, возможность снижения мужской фертильности не может быть исключена.\u003Cbr\u003EРак предстательной железы (РПЖ)\u003Cbr\u003EВ 4-летнем исследовании участвовали более 8000 мужчин в возрасте от 50 до 75 лет, характеризующихся отрицательным результатом биопсии на наличие РПЖ и концентрацией простат-специфического антигена (ПСА) между 2,5 нг/мл и 10.0 нг/мл (исследование REDUCE) при первичном обследовании, при этом у 1517 из них был диагностирован РПЖ. Зарегистрировано больше случаев РПЖ с оценкой 8-10 баллов по шкале Глисона в группе дутастерида (п=29: 0.9%) по сравнению с группой плацебо (п=19; 0,6%). Не отмечалось увеличения количества случаев РПЖ с оценкой 5-6 и 7-10 баллов по шкале Глисона. Причинно-следственная связь между приемом дутастерида и развитием РПЖ высокой степени градации не установлена. Клиническое значение количественного дисбаланса неизвестно. Мужчины, принимающие дутастерид, должны регулярно проходить обследования в отношении оценки риска развития РПЖ, включая определение концентрации ПСА.\u003Cbr\u003EВ дополнительном 2-летнем исследовании, направленном на последующее наблюдение пациентов из исследования REDUCE по химиопрофилактике, новые случаи РПЖ диагностировались редко (дутастерид (п=14, 1,2%) и плацебо (п=7, 0,7%)), новые случаи РПЖ с оценкой 8-10 баллов по шкале Глисона отсутствовали.\u003Cbr\u003EДолгосрочные наблюдения (до 18 лет) в исследовании по химиопрофилактике с помощью другого ингибитора 5а-редуктазы (финастерид) не выявили статистически значимое различие в применении финастерида и плацебо по показателям общей выживаемости (ОР 1,02; 95 % ДИ 0,97-1,08) или выживаемости после подтверждения диагноза РПЖ (ОР 1,01; 95 %, ДИ 0.85-1,20).\u003Cbr\u003EПростат-специфический антиген (ПСА)\u003Cbr\u003EОпределение концентрации ПСА является важным компонентом скрининга, направленного на выявление РПЖ. После 6-месячной терапии дутастеридом средняя концентрация ПСА в сыворотке крови снижается примерно на 50 %. Для пациентов, принимающих дутастерид, должна быть установлена новая базовая концентрация ПСА после 6 месяцев терапии. После этого рекомендуется регулярное мониторирование концентрации ПСА. Любое подтвержденное повышение концентрации ПСА относительно наименьшего его значения при лечении дутастеридом может свидетельствовать о развитии РПЖ или о несоблюдении режима терапии препаратом и должно подвергаться тщательной оценке, даже если эти концентрации ПСА остаются в пределах нормальных значений для мужчин, не принимающих ингибиторы 5а- редуктазы. При интерпретации значений концентрации ПСА у пациентов, принимающих дутастерид, необходимо использовать для сравнения предыдущие результаты оценки концентрации ПСА. Применение дутастерида не влияет на диагностическую ценность определения концентрации ПСА как маркера РПЖ после того, как установлена новая базовая концентрация ПСА.\u003Cbr\u003EКонцентрация общего ПСА в сыворотке крови возвращается к исходному значению в течение 6 месяцев после отмены дутастерида.\u003Cbr\u003EОтношение концентрации свободного ПСА к общему остается постоянным даже на фоне терапии дутастеридом. Если для выявления РПЖ у мужчин, получающих дутастерид, дополнительно используется определение процентного содержания свободной фракции ПСА, не требуется проводить коррекцию этого показателя. У пациентов необходимо проводить пальцевое ректальное исследование и использовать другие методы диагностики РПЖ до начала лечения дутастеридом, а также регулярно повторять обследование пациента в процессе лечения.\u003Cbr\u003EНежелательные явления (НЯ) со стороны сердечно-сосудистой системы\u003Cbr\u003EВ двух 4-летних клинических исследованиях частота развития сердечной недостаточности (обобщенный термин для наблюдавшихся событий, представленных в основном сердечной недостаточностью и хронической сердечной недостаточностью) была выше у пациентов, получавших комбинацию дутастерида и a i-адреноблокатора, главным образом, тамсулозина, чем у пациентов, не получавших комбинированного лечения. В этих двух клинических исследованиях частота развития сердечной недостаточности оставалась низкой (\u003C1%) и варьировала между исследованиями. В целом различия между показателями частоты НЯ со стороны сердечно-сосудистой системы в обоих исследованиях не отмечались. Причинно-следственная связь между приемом дутастерида (в виде монотерапии или в комбинации с ai-адреноблокатором) и сердечной недостаточностью не установлена.\u003Cbr\u003EПри мета-анализе 12 рандомизированных, контролируемых с помощью плацебо или препаратов сравнения клинических исследований (п=18802), целью которого являлась оценка риска развития сердечно-сосудистых НЯ при применении дутастерида (по сравнению с контрольной группой), не выявлено соответствующего статистически значимого увеличения риска развития сердечной недостаточности (ОР 1,05; 95% ДИ 0,71, 1,57), острого инфаркта миокарда (ОР 1.00; 95 °/оДИ0Д'1, 1,30) или инсульта (ОР 1,20; 95 % Ж 0.88. 1,64).\u003Cbr\u003EРак грудной железы\u003Cbr\u003EПри проведении клинических исследований и в пострегистрационном периоде зарегистрированы редкие сообщения о развитии рака грудной железы у мужчин, принимающих дутастерид. Тем не менее, данные эпидемиологических исследований не свидетельствуют о повышении риска развития рака грудной железы у мужчин при применении ингибиторов 5а-редуктазы. Специалисты должны проинструктировать пациентов о необходимости немедленно сообщать о любых изменениях со стороны грудных желез, таких как уплотнения в железе или выделения из соска.\u003Cbr\u003EНарушения функции печени\u003Cbr\u003EВлияние нарушения функции печени на фармакокинетику дутастерида не исследовалось. Поскольку дутастерид интенсивно метаболизируется и его период полувыведения составляет от 3 до 5 недель, следует с осторожностью назначать дутастерид пациентам с нарушением функции печени.\u003Cbr\u003EУтечка содержимого капсул\u003Cbr\u003EДутастерид всасывается через кожу, поэтому женщины и дети должны избегать контакта с капсулами, у которых наблюдается утечка содержимого. В случае контакта с такими капсулами затронутую область следует немедленно промыть водой с мылом.\u003Cbr\u003E"},{"name":"Взаимодействие","value":"In vitro дутастерид метаболизируется изоферментом CYP3A4 системы цитохрома Р450 человека. Следовательно, в присутствии ингибиторов CYP3A4 концентрации дутастерида в крови могут возрастать.\n\u003Cbr\u003EПри одновременном применении дутастерида с ингибиторами CYP3A4 верапамилом и дилтиаземом отмечается снижение клиренса дутастерида. Вместе с тем, амлодипин, другие блокаторы «медленных» кальциевых каналов (БМКК) при одновременном применении с дутастеридом не уменьшают клиренс дутастерида. Уменьшение клиренса дутастерида и последующее повышение его концентрации в крови в присутствии ингибиторов CYP3A4 не является клинически значимым вследствие широкого диапазона границ безопасности дутастерида, поэтому нет необходимости корректировать его дозу.\nIn vitro дутастерид не метаболизируется следующими изоферментами системы цитохрома Р450 человека: CYP1A2, CYP2A6. CYP2E1, CYP2C8. CYP2C9, CYP2C19. CYP2B6 или CYP2D6.\n\u003Cbr\u003EДутастерид не ингибирует in vitro ферменты системы цитохрома Р450 человека, участвующие в метаболизме лекарственных препаратов.\n\u003Cbr\u003EIn vitro дутастерид не вытесняет варфарин, аценокумарол, фенпрокумон, диазепам и фенитоин из участков их связывания с белками плазмы, а эти препараты, в свою очередь, не вытесняют дутастерид.\n\u003Cbr\u003EПри проведении исследований взаимодействия дутастерида с тамсулозином. теразозином, варфарином, дигоксином и колестирамином у человека каких-либо клинически значимых фармакокинетических или фармакодинамических взаимодействий не отмечалось.\n\u003Cbr\u003EПри применении дутастерида одновременно с гиполипидемическими препаратами, ингибиторами ангиотензинпревращающего фермента, бета-адреноблокаторами. БМКК. глюкокортикостероидами, диуретиками, нестероидными противовоспалительными препаратами, ингибиторами фосфодиэстеразы V-ro типа и хинолоновыми антибиотиками каких-либо значимых нежелательных лекарственных взаимодействий не наблюдалось."},{"name":"Регистрационный номер","value":"ЛП-005368"},{"name":"Дата государственной регистрации","value":"20.08.2020"},{"name":"Владелец регистрационного удостоверения","value":"TEVA","transition":{"type":"catalog","params":{"categorySlug":"mochepolovaia-sistema-i-polovye-gormony","categoryId":"15756910","navnodeId":"72506","glfilters":["34324371:35649313","7893318:14909142"]}}},{"name":"Изготовитель","value":"Teva Pharmaceutical Private Co. Ltd"},{"name":"Фасовщик","value":"Teva Pharmaceutical Private Co. Ltd"},{"name":"Страна бренда","value":"Израиль"},{"name":"Страна-производитель","value":"Венгрия"},{"name":"Название препарата","value":"Дутастерид","transition":{"type":"catalog","params":{"categorySlug":"mochepolovaia-sistema-i-polovye-gormony","categoryId":"15756910","navnodeId":"72506","glfilters":["17796364:18038306"]}}},{"name":"Срок годности","value":"24 мес."}]}},"fullSpecsGrouped":{"9977646863026871925":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"половая система"},{"name":"Назначение","value":"доброкачественная гиперплазия предстательной железы"},{"name":"Показания к применению","value":"Препарат Гардиум назначают пациентам:\u003Cbr\u003E- в качестве монотерапии для лечения и профилактики прогрессирования доброкачественной гиперплазии предстательной железы посредством уменьшения её размеров, облегчения симптомов, улучшения мочеиспускания, снижения риска возникновения острой задержки мочи и необходимости оперативного вмешательства.\u003Cbr\u003E- в качестве комбинированной терапии с a1-адреноблокаторами для лечения и\nпрофилактики прогрессирования доброкачественной гиперплазии предстательной железы посредством уменьшения её размеров, облегчения симптомов, улучшения мочеиспускания, снижения риска возникновения острой задержки мочи и необходимости оперативного вмешательства. В основном изучалась комбинация дутастерида и a1-адреноблокатора тамсулозина."},{"name":"Противопоказания","value":"Препарат противопоказан пациентам с гиперчувствительностью к дутастериду или любому компоненту препарата и другим ингибиторам 5а-редуктазы. Применение препарата противопоказано женщинам и детям. Применение препарата противопоказано пациентам с тяжелыми нарушениями функции печени."},{"name":"Состав","value":"в 1 капсуле содержится:\u003Cbr\u003Eдействующее вещество дутастерид 0,500 мг;\u003Cbr\u003Eвспомогательные вещества: бутилгидрокситолуол (E32I) 0.035мг, глицерол монокаприлокапрат (тип I) 349,465 мг;\u003Cbr\u003Eоболочка капсулы: желатин 160,150 мг, глицерол (Е422) 95,329 мг, Opatint белый (G-18000) (глицерол (Е422) 3,812 мг, титана диоксид (Е171) 1,907 мг), Opatint желтый (G-12014) (глицерол (Е422) 0,642 мг, железа оксид желтый (Е172) 0.160 мг), триглицериды среднецепочечные (следовое количество)."},{"name":"Действующее вещество","value":"Дутастерид"},{"name":"Способ применения и дозы","value":"Внутрь один раз в сутки независимо от приема пищи.\u003Cbr\u003EКапсулы препарата Гардиум следует глотать целиком, не разжевывать, не открывать, поскольку содержимое капсулы может вызывать раздражение слизистой ротоглотки.\u003Cbr\u003EДоброкачественная гиперплазия предстательной железы Взрослые мужчины (включая пожилых)\u003Cbr\u003EРекомендуемая доза препарата Гардиум - одна капсула (0,5 мг) один раз в сутки перорально. Капсулы следует принимать целиком.\u003Cbr\u003EХотя улучшение на фоне применения препарата наступает довольно быстро, лечение следует продолжать не менее 6 месяцев для того, чтобы объективно оценить терапевтический эффект.\u003Cbr\u003EДля лечения ДГПЖ препарат Гардиум может быть назначен в качестве монотерапии или в комбинации с a1-адреноблокаторами.\u003Cbr\u003EОсобые группы пациентов Пациенты с нарушениями функции почек.\u003Cbr\u003EПри приеме 0,5 мг препарата в сутки почками выделяется менее 0,1% дозы, поэтому нет необходимости снижать дозу у пациентов с нарушениями функции почек.\u003Cbr\u003EПациенты с нарушениями функции печени.\u003Cbr\u003EВ настоящее время нет данных по применению препарата Гардиум у пациентов с нарушениями функции печени. Так как дутастерид подвергается интенсивному метаболизму, а его период полувыведения составляет 3-5 недель, необходимо соблюдать осторожность при лечении препаратом Гардиум пациентов с нарушениями функции печени."},{"name":"Побочные действия","value":"Применение дутастерида в качестве монотерапии\u003Cbr\u003EПеречисленные ниже нежелательные явления (НЯ) по данным контролируемых клинических исследований и данным постмаркетингового наблюдения - это отмеченные исследователями случаи, связанные с приемом препарата (с частотой возникновения, большей либо равной 1%), которые отмечались с более высокой частотой у пациентов, лечившихся дутастеридом в течение первого года лечения, по сравнению с пациентами, получавшими плацебо. НЯ по данным пострегистрационного опыта применения выявлены из случайно отобранных пострегистрационных отчетов: таким образом, реальная частота их возникновения неизвестна.\n\u003Cbr\u003EНЯ систематизированы в соответствии с Классификацией Всемирной организации здравоохранения (ВОЗ): очень часто (\u003E1/10), часто (\u003E1/100 и \u003C1/10), нечасто (\u003E1/1000 и \u003C1/100), редко (\u003E1/10000 и \u003C1/1000), очень редко (\u003C1/10000); неизвестно (невозможно определить на основе имеющихся данных).\u003Cbr\u003EНарушения со стороны репродуктивной системы и грудных желез:\u003Cbr\u003E-эректильная дисфункция(Частота возникновения в течение 1-го года лечения (п=2167) - 6%;Частота возникновения в течение 2-го года лечения (п=1744) - 1,7%)\u003Cbr\u003E-изменение (снижение)либидо(Частота возникновения в течение 1-го года лечения (п=2167) - 3,7%; Частота возникновения в течение 2-го года лечения (п=1744) - 0,6%)\u003Cbr\u003E-нарушения эякуляции*++(1,8%;0,5%)\u003Cbr\u003E-изменения грудных желез+(1,3%;1,3%)\u003Cbr\u003EЧастота возникновения оценивалась по пострегистрационным данным\u003Cbr\u003EНарушения со стороны иммунной системы:\u003Cbr\u003E-аллергические реакции, включая высыпания, зуд, крапивницу, локализованный отек и отек Квинке(неизвестно)\u003Cbr\u003EНарушения психики:\u003Cbr\u003E-депрессивное состояние(неизвестно)\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей:\u003Cbr\u003E-алопеция (в первую очередь, выпадение волос на теле), гипертрихоз(нечастно)\u003Cbr\u003EНарушения со стороны репродуктивной системы и молочных желез:\u003Cbr\u003E-тестикулярные боли и увеличение яичек(неизвестно)\u003Cbr\u003E*Данные НЯ в сексуальной сфере связаны с лечением дутастеридом(включая монотерапию и сочетание с тамсулозином). \u003Cbr\u003EДанные НЯ могут сохраняться и после прекращения лечения. Роль дутастерида в сохранении данного эффекта неизвестна\u003Cbr\u003EВключают болезненность и увеличение грудных желез + уменьшение объема спермы\u003Cbr\u003EПрименение дутастерида в комбинации с тамсулозином\u003Cbr\u003EРезультаты 4-лстнего исследования CombAT, сравнивающего дутастерид 0,5 мг (п=1623) и тамсулозина 0,4 мг (п=16 11) один раз в сутки в виде монотерапии или в комбинации, показали, что частота НЯ, оцененных исследователями как связанных с препаратом/комбинацией препаратов, в течении первого, второго, третьего и четвертого года исследования составляла соответственно 22%, 6%, 4% и 2% для комбинированной терапии дутастеридом/тамсулозином; 15%, 6%, 3% и 2% для монотерапии тамсулозином. Более высокая частота НЯ в группе комбинированной терапии в первый год лечения была связана с более высокой частотой репродуктивных расстройств, в частности нарушений эякуляции, наблюдаемых в этой группе.\u003Cbr\u003EСообщалось о следующих НЯ, оцененных исследователями как связанных с препаратом/комбинацией препаратов, встречающихся с частотой \u003E 1% в течении первого года лечения в исследовании CombAT: частота этих НЯ в течении четырех лет исследования представлена в таблице ниже:\u003Cbr\u003EКоличество пациентов (n) и частота (%) возникновения за период лечения\u003Cbr\u003EКомбинация1-1 год - п=1610, 2й год - п=1428, 3-й год - п=1238, 4й год - п=1200\u003Cbr\u003EДутастерид-(n=1623)-(n=1464)-(n=1325)-(n=1200)\u003Cbr\u003EТамсулозин-(n=1611)-(n=1468)-(n=1281)-(n=1112)\u003Cbr\u003EСо стороны нервной системы\n\u003Cbr\u003EГоловокружение\u003Cbr\u003EКомбинация-1.4%-0.1%-\u003C0.1%-0.2%\u003Cbr\u003EДутастерид-0.7%-0.1%-\u003C0.1%-\u003C0.1%\u003Cbr\u003EТамсулозин-1.3%-0.4%-\u003C0.1%-0%\u003Cbr\u003EСо стороны сердечно-сосудистой системы\u003Cbr\u003EСердечная недостаточность2\u003Cbr\u003EКомбинация-0.2%-0.4%-0.2%-0.2%\u003Cbr\u003EДутастерид-\u003C0.1%-0.1%-\u003C0.1%-0%\u003Cbr\u003EТамсулозин-0.1%-\u003C0.1%-0.4%-0.2%\u003Cbr\u003EСо стороны репродуктивной системы и грудной железы\u003Cbr\u003EЭректильная дисфункция3\u003Cbr\u003EКомбинация-6.3%-1.8%-0.9%-0.4%\u003Cbr\u003EДутастерид-5.1%-1.6%-0.6%-0.3%\u003Cbr\u003EТамсулозин-3.3%-1.0%-0.6%-1.1%\u003Cbr\u003EСнижение либидо3\u003Cbr\u003EКомбинация-5.3%-0.8%-0.2%-0%\u003Cbr\u003EДутастерид-3.8%-1.0%-0.2%-0%\u003Cbr\u003EТамсулозин-2.5%-0.7%-0.2%-\u003C0.1%\u003Cbr\u003EНарушения эякуляции3,5\u003Cbr\u003EКомбинация-9.0%-1.0%-0.5%-\u003C0.1%\u003Cbr\u003EДутастерид-1.5%-0.5%-0.2%-0.3%\u003Cbr\u003EТамсулозин-2.7%-0.5%-0.2%-0.3%\u003Cbr\u003EИзменения грудной железы4\u003Cbr\u003EКомбинация-2.1%-0.8%-0.9%-0.6%\u003Cbr\u003EДутастерид-1.7%-1.2%-0.5%-0.7%\u003Cbr\u003EТамсулозин-0.8%-0.4%-0.2%-0%\u003Cbr\u003E1 Комбинация = Дутастерид-Тева 0.5 мг 1 раз/сут + тамсулозин 0.4 мг 1 раз/сут;\u003Cbr\u003E2 Включая хроническую сердечную недостаточность, сердечную недостаточность, левожелудочковую недостаточность, острую сердечную недостаточность, кардиогенный шок, острую левожелудочковую недостаточность, правожелудочковую недостаточность, острую правожелудочковую недостаточность, желудочковую недостаточность, сердечно-легочную недостаточность, застойную кардиомиопатию;\u003Cbr\u003E3 НЯ со стороны репродуктивной системы и грудных желез, связанные с применением препарата Дутастерид-Тева (как при монотерапии, так и в комбинации с тамсулозином). Данные НЯ могут сохраняться после прекращения лечения и влияние препарата Дутастерид-Тева на сохранение данных НЯ неизвестно;\u003Cbr\u003E4 Включают болезненность и увеличение грудных желез;\u003Cbr\u003E5 Уменьшение объема спермы."},{"name":"Фармакологическое действие","value":"Максимальное влияние суточных доз дутастерида на снижение концентрации ДГТ является дозозависимым и наблюдается в течение 1-2 недель. Через 1 и 2 недели приема дутастерида в дозе 0.5 мг в сутки средние значения концентраций ДГТ в сыворотке крови снижались на 85% и 90% соответственно.\u003Cbr\u003EУ пациентов с доброкачественной гиперплазией предстательной железы (ДГПЖ), получавших 0.5 мг дутастерида в сутки, среднее снижение концентрации ДГТ составило 94% через 1 год и 93% через 2 года, среднее увеличение концентрации тестостерона в сыворотке крови составило 19% как через 1 год, так и через 2 года. Это является ожидаемым последствием ингибирования 5а-редуктазы и не приводит ни к одному из известных нежелательных явлений."},{"name":"Фармакологическая группа","value":"5-альфа редуктазы ингибитор"},{"name":"Форма выпуска","value":"капсулы"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Пол","value":"для мужчин"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Хранить при температуре не выше 25 °C, в оригинальной упаковке.\nХранить в недоступном для детей месте."},{"name":"Передозировка","value":"При применении дутастерида до 40 мг/день однократно (в 80 раз выше терапевтической дозы) в течение 7 дней значимых побочных эффектов не отмечалось.\nПри проведении клинических исследований пациенты в течение 6 месяцев получали дутастерид в дозе 5 мг ежедневно, при этом каких-либо дополнительных побочных эффектов к тем, что наблюдались на фоне приема 0.5 мг дутастерида. обнаружено не было. Специфического антидота дутастерида нет, поэтому при подозрении на передозировку достаточно проводить симптоматическое и поддерживающее лечение."},{"name":"Применение при беременности и кормлении грудью","value":"Беременность.\u003Cbr\u003EДутастерид противопоказан женщинам. Дутастерид не изучался у женщин, так как доклинические данные свидетельствуют о том, что подавление уровня ДГТ может вызывать торможение развития наружных половых органов у плода мужского пола.\u003Cbr\u003EГрудное вскармливание:\u003Cbr\u003Eнет данных о проникновении дутастерида в грудное молоко."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Прием дутастерида не влияет на способность управлять транспортными средствами и\nмеханизмами."},{"name":"Особые указания","value":"С осторожностью: печеночная недостаточность.\u003Cbr\u003EФертильность\u003Cbr\u003EВлияние дутастерида в суточной дозе 0,5 мг на характеристики спермы изучалось у здоровых добровольцев в возрасте 18-52 лет на протяжении 52 недель лечения и последующего 24 недельного наблюдения. К 52-й неделе лечения в группе пациентов, получавших дутастерид, средние значения процентного снижения общего количества сперматозоидов, объема спермы и двигательной активности сперматозоидов составляли 23%, 26% и 18% соответственно, по сравнению с исходным уровнем в группе пациентов, получавших плацебо. Концентрация сперматозоидов и их морфология не изменялись.\u003Cbr\u003EЧерез 24 недели последующего наблюдения среднее значение изменения общего количества сперматозоидов в группе дутастерида оставалось на 23% ниже по сравнению с исходным уровнем. В то время, как средние значения всех параметров спермы во всех временных точках оставались в пределах нормы и не соответствовали заданным критериям для клинически значимых изменений (30%), у двух добровольцев в группе дутастерида общее количество сперматозоидов на 52-ой неделе снижалось более чем на 90% по сравнению с исходным уровнем, с частичным восстановлением на 24-й неделе наблюдения. Таким образом, возможность снижения мужской фертильности не может быть исключена.\u003Cbr\u003EРак предстательной железы (РПЖ)\u003Cbr\u003EВ 4-летнем исследовании участвовали более 8000 мужчин в возрасте от 50 до 75 лет, характеризующихся отрицательным результатом биопсии на наличие РПЖ и концентрацией простат-специфического антигена (ПСА) между 2,5 нг/мл и 10.0 нг/мл (исследование REDUCE) при первичном обследовании, при этом у 1517 из них был диагностирован РПЖ. Зарегистрировано больше случаев РПЖ с оценкой 8-10 баллов по шкале Глисона в группе дутастерида (п=29: 0.9%) по сравнению с группой плацебо (п=19; 0,6%). Не отмечалось увеличения количества случаев РПЖ с оценкой 5-6 и 7-10 баллов по шкале Глисона. Причинно-следственная связь между приемом дутастерида и развитием РПЖ высокой степени градации не установлена. Клиническое значение количественного дисбаланса неизвестно. Мужчины, принимающие дутастерид, должны регулярно проходить обследования в отношении оценки риска развития РПЖ, включая определение концентрации ПСА.\u003Cbr\u003EВ дополнительном 2-летнем исследовании, направленном на последующее наблюдение пациентов из исследования REDUCE по химиопрофилактике, новые случаи РПЖ диагностировались редко (дутастерид (п=14, 1,2%) и плацебо (п=7, 0,7%)), новые случаи РПЖ с оценкой 8-10 баллов по шкале Глисона отсутствовали.\u003Cbr\u003EДолгосрочные наблюдения (до 18 лет) в исследовании по химиопрофилактике с помощью другого ингибитора 5а-редуктазы (финастерид) не выявили статистически значимое различие в применении финастерида и плацебо по показателям общей выживаемости (ОР 1,02; 95 % ДИ 0,97-1,08) или выживаемости после подтверждения диагноза РПЖ (ОР 1,01; 95 %, ДИ 0.85-1,20).\u003Cbr\u003EПростат-специфический антиген (ПСА)\u003Cbr\u003EОпределение концентрации ПСА является важным компонентом скрининга, направленного на выявление РПЖ. После 6-месячной терапии дутастеридом средняя концентрация ПСА в сыворотке крови снижается примерно на 50 %. Для пациентов, принимающих дутастерид, должна быть установлена новая базовая концентрация ПСА после 6 месяцев терапии. После этого рекомендуется регулярное мониторирование концентрации ПСА. Любое подтвержденное повышение концентрации ПСА относительно наименьшего его значения при лечении дутастеридом может свидетельствовать о развитии РПЖ или о несоблюдении режима терапии препаратом и должно подвергаться тщательной оценке, даже если эти концентрации ПСА остаются в пределах нормальных значений для мужчин, не принимающих ингибиторы 5а- редуктазы. При интерпретации значений концентрации ПСА у пациентов, принимающих дутастерид, необходимо использовать для сравнения предыдущие результаты оценки концентрации ПСА. Применение дутастерида не влияет на диагностическую ценность определения концентрации ПСА как маркера РПЖ после того, как установлена новая базовая концентрация ПСА.\u003Cbr\u003EКонцентрация общего ПСА в сыворотке крови возвращается к исходному значению в течение 6 месяцев после отмены дутастерида.\u003Cbr\u003EОтношение концентрации свободного ПСА к общему остается постоянным даже на фоне терапии дутастеридом. Если для выявления РПЖ у мужчин, получающих дутастерид, дополнительно используется определение процентного содержания свободной фракции ПСА, не требуется проводить коррекцию этого показателя. У пациентов необходимо проводить пальцевое ректальное исследование и использовать другие методы диагностики РПЖ до начала лечения дутастеридом, а также регулярно повторять обследование пациента в процессе лечения.\u003Cbr\u003EНежелательные явления (НЯ) со стороны сердечно-сосудистой системы\u003Cbr\u003EВ двух 4-летних клинических исследованиях частота развития сердечной недостаточности (обобщенный термин для наблюдавшихся событий, представленных в основном сердечной недостаточностью и хронической сердечной недостаточностью) была выше у пациентов, получавших комбинацию дутастерида и a i-адреноблокатора, главным образом, тамсулозина, чем у пациентов, не получавших комбинированного лечения. В этих двух клинических исследованиях частота развития сердечной недостаточности оставалась низкой (\u003C1%) и варьировала между исследованиями. В целом различия между показателями частоты НЯ со стороны сердечно-сосудистой системы в обоих исследованиях не отмечались. Причинно-следственная связь между приемом дутастерида (в виде монотерапии или в комбинации с ai-адреноблокатором) и сердечной недостаточностью не установлена.\u003Cbr\u003EПри мета-анализе 12 рандомизированных, контролируемых с помощью плацебо или препаратов сравнения клинических исследований (п=18802), целью которого являлась оценка риска развития сердечно-сосудистых НЯ при применении дутастерида (по сравнению с контрольной группой), не выявлено соответствующего статистически значимого увеличения риска развития сердечной недостаточности (ОР 1,05; 95% ДИ 0,71, 1,57), острого инфаркта миокарда (ОР 1.00; 95 °/оДИ0Д'1, 1,30) или инсульта (ОР 1,20; 95 % Ж 0.88. 1,64).\u003Cbr\u003EРак грудной железы\u003Cbr\u003EПри проведении клинических исследований и в пострегистрационном периоде зарегистрированы редкие сообщения о развитии рака грудной железы у мужчин, принимающих дутастерид. Тем не менее, данные эпидемиологических исследований не свидетельствуют о повышении риска развития рака грудной железы у мужчин при применении ингибиторов 5а-редуктазы. Специалисты должны проинструктировать пациентов о необходимости немедленно сообщать о любых изменениях со стороны грудных желез, таких как уплотнения в железе или выделения из соска.\u003Cbr\u003EНарушения функции печени\u003Cbr\u003EВлияние нарушения функции печени на фармакокинетику дутастерида не исследовалось. Поскольку дутастерид интенсивно метаболизируется и его период полувыведения составляет от 3 до 5 недель, следует с осторожностью назначать дутастерид пациентам с нарушением функции печени.\u003Cbr\u003EУтечка содержимого капсул\u003Cbr\u003EДутастерид всасывается через кожу, поэтому женщины и дети должны избегать контакта с капсулами, у которых наблюдается утечка содержимого. В случае контакта с такими капсулами затронутую область следует немедленно промыть водой с мылом.\u003Cbr\u003E"},{"name":"Взаимодействие","value":"In vitro дутастерид метаболизируется изоферментом CYP3A4 системы цитохрома Р450 человека. Следовательно, в присутствии ингибиторов CYP3A4 концентрации дутастерида в крови могут возрастать.\n\u003Cbr\u003EПри одновременном применении дутастерида с ингибиторами CYP3A4 верапамилом и дилтиаземом отмечается снижение клиренса дутастерида. Вместе с тем, амлодипин, другие блокаторы «медленных» кальциевых каналов (БМКК) при одновременном применении с дутастеридом не уменьшают клиренс дутастерида. Уменьшение клиренса дутастерида и последующее повышение его концентрации в крови в присутствии ингибиторов CYP3A4 не является клинически значимым вследствие широкого диапазона границ безопасности дутастерида, поэтому нет необходимости корректировать его дозу.\nIn vitro дутастерид не метаболизируется следующими изоферментами системы цитохрома Р450 человека: CYP1A2, CYP2A6. CYP2E1, CYP2C8. CYP2C9, CYP2C19. CYP2B6 или CYP2D6.\n\u003Cbr\u003EДутастерид не ингибирует in vitro ферменты системы цитохрома Р450 человека, участвующие в метаболизме лекарственных препаратов.\n\u003Cbr\u003EIn vitro дутастерид не вытесняет варфарин, аценокумарол, фенпрокумон, диазепам и фенитоин из участков их связывания с белками плазмы, а эти препараты, в свою очередь, не вытесняют дутастерид.\n\u003Cbr\u003EПри проведении исследований взаимодействия дутастерида с тамсулозином. теразозином, варфарином, дигоксином и колестирамином у человека каких-либо клинически значимых фармакокинетических или фармакодинамических взаимодействий не отмечалось.\n\u003Cbr\u003EПри применении дутастерида одновременно с гиполипидемическими препаратами, ингибиторами ангиотензинпревращающего фермента, бета-адреноблокаторами. БМКК. глюкокортикостероидами, диуретиками, нестероидными противовоспалительными препаратами, ингибиторами фосфодиэстеразы V-ro типа и хинолоновыми антибиотиками каких-либо значимых нежелательных лекарственных взаимодействий не наблюдалось."},{"name":"Регистрационный номер","value":"ЛП-005368"},{"name":"Дата государственной регистрации","value":"20.08.2020"},{"name":"Владелец регистрационного удостоверения","value":"TEVA"},{"name":"Изготовитель","value":"Teva Pharmaceutical Private Co. Ltd"},{"name":"Фасовщик","value":"Teva Pharmaceutical Private Co. Ltd"},{"name":"Страна бренда","value":"Израиль"},{"name":"Страна-производитель","value":"Венгрия"},{"name":"Название препарата","value":"Дутастерид"},{"name":"Срок годности","value":"24 мес."}]}],"transitionId":"tr_9710781189281241057"}}}}
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    Цена 399 ₽
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  • Финастерид-OBL таб. п/о плен., 5 мг, 30 шт.
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    Финастерид-OBL таб. п/о плен., 5 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 7 оценок
    Цена 301 ₽
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  • Дуодарт капс. модиф. высвоб., 0.5 мг+0.4 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-hgqdu3jdzii/toggleWishlist":{"skuId":"186920076","productId":1430912450,"offerId":"Gt_gzL2G77nNcs_iV-YqPQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ25nRweH7vvZnEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIwvunqgUQjNmQWRjHxp4IIO7cwQc=","sign":"U9gygDdnQduOhBYJGYWSLgv7SG/H8gUHOmGUDZVxsNM="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-hgqdu3jdzii/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Дуодарт капс. модиф. высвоб., 0.5 мг+0.4 мг, 30 шт.

    Рейтинг товара: 4.5 из 5
    на основе 17 оценок
    Цена 2 839 ₽
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-hgqdu3jdzii/addToCartButton":{"offerId":"Gt_gzL2G77nNcs_iV-YqPQ","skuId":"186920076","pendingCartItem":{"productId":1430912450,"offerId":"Gt_gzL2G77nNcs_iV-YqPQ","showPlaceId":"OTNDnItfwRMjN9MRHuEMMoPlIefzBuIfUuCHzV1K3CB8hsINV9Xi7nbdqLwCpHdCNwBSq1ejAtzGiQqaO3dZv4DW7NKqL0JXSrk3O0CLDfztQ7lufbEHkEOs4hCKn8UQY1xfbKigP7c-CPh1uM-9t5k4WogXV53ftXYRjEEqFqgG6idybR_ucVUceX3FJYt3NurQoGeO0EMAybX3JoBq3Q,,","feeShow":"OTNDnItfwRMjN9MRHuEMMoPlIefzBuIfUuCHzV1K3CB8hsINV9Xi7nbdqLwCpHdCNwBSq1ejAtzGiQqaO3dZv4DW7NKqL0JXSrk3O0CLDfztQ7lufbEHkEOs4hCKn8UQY1xfbKigP7c-CPh1uM-9t5k4WogXV53ftXYRjEEqFqgG6idybR_ucVUceX3FJYt3NurQoGeO0EMAybX3JoBq3Q,,","skuId":"186920076","shopId":55106433,"price":{"applicablePriceDiscounts":[],"value":"2839","currency":"RUR"},"hid":"15756910","name":"Дуодарт капс. модиф. высвоб., 0.5 мг+0.4 мг, 30 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  • Пенестер таб. п/о плен., 5 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-a0fp6pom8z7/toggleWishlist":{"skuId":"228054945","productId":1430912452,"offerId":"X-PVrPyOAuMa1Kt_xB8XOA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ25nRweH7vvZnEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIxPunqgUQoa/fbBjJy/UHIO7cwQc=","sign":"w7hQdl2fVQrrYYkIyMBoOeJJDpLPuf2WM6pcsOnIHqw="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-a0fp6pom8z7/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Пенестер таб. п/о плен., 5 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 4 оценки
    Цена 530 ₽
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  • Цистофит-форте таб., 40 шт.
    –29 %
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    Цистофит-форте таб., 40 шт.

    Цена 493 ₽ вместо 690
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  • Тамсулозин Канон капс. кш/раств. с пролонг. высвоб., 0.4 мг, 30 шт.
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    Тамсулозин Канон капс. кш/раств. с пролонг. высвоб., 0.4 мг, 30 шт.

    Рейтинг товара: 4.6 из 5
    на основе 21 оценка
    Цена 403 ₽
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  • Финаст таб. п/о плен., 5 мг, 30 шт.
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    Финаст таб. п/о плен., 5 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 374 ₽
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  • Тамсулозин-Вертекс таб. пролонг. высвоб. п/о плен., 0.4 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-9f3kc00a5ls/toggleWishlist":{"skuId":"826827025","productId":1778176037,"offerId":"p36ralLCVzY3OBoYMIANew","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ25nRweH7vvZnEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIpaDzzwYQkcKhigMYtNWHBCDu3MEH","sign":"9oT4zItn2a18BlaXb8oDSON+CZtwUncCOe4PeWex3b4="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-9f3kc00a5ls/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Тамсулозин-Вертекс таб. пролонг. высвоб. п/о плен., 0.4 мг, 30 шт.

    Рейтинг товара: 4.9 из 5
    на основе 19 оценок
    Цена 445 ₽
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  • Ципротерон-Тева таб., 50 мг, 50 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-eucmyit2y75/toggleWishlist":{"skuId":"663856005","productId":1778175906,"offerId":"VgIocXyEgJ0a7d-jRdjg-Q","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ25nRweH7vvZnEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIop/zzwYQhcfGvAIY1v2NByDu3MEH","sign":"gdysxWS9/DiH9PaD5P8u5b7TaSjz/I3EkEHtD7u3VQw="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-eucmyit2y75/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Ципротерон-Тева таб., 50 мг, 50 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 1 696 ₽
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  • Тадалафил-СЗ таб. п/о плен., 20 мг, 4 шт.
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    Тадалафил-СЗ таб. п/о плен., 20 мг, 4 шт.

    Рейтинг товара: 4.6 из 5
    на основе 213 оценок
    Цена 260 ₽
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  • Урорек капс., 8 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-hvu5riryumg/toggleWishlist":{"skuId":"186868780","productId":1430912442,"offerId":"yd3xNEsQThBDqn1GPBi8vQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ25nRweH7vvZnEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIuvunqgUQrMiNWRiklcIIIO7cwQc=","sign":"OjolhhD+diLEhf/+TQ307e/EogWFnGlXkDvaNiZFs1w="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-hvu5riryumg/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Урорек капс., 8 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 13 оценок
    Цена 1 112 ₽
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Инструкция

Показания к применению

Препарат Гардиум назначают пациентам:
- в качестве монотерапии для лечения и профилактики прогрессирования доброкачественной гиперплазии предстательной железы посредством уменьшения её размеров, облегчения симптомов, улучшения мочеиспускания, снижения риска возникновения острой задержки мочи и необходимости оперативного вмешательства.
- в качестве комбинированной терапии с a1-адреноблокаторами для лечения и профилактики прогрессирования доброкачественной гиперплазии предстательной железы посредством уменьшения её размеров, облегчения симптомов, улучшения мочеиспускания, снижения риска возникновения острой задержки мочи и необходимости оперативного вмешательства. В основном изучалась комбинация дутастерида и a1-адреноблокатора тамсулозина.

Противопоказания

Препарат противопоказан пациентам с гиперчувствительностью к дутастериду или любому компоненту препарата и другим ингибиторам 5а-редуктазы. Применение препарата противопоказано женщинам и детям. Применение препарата противопоказано пациентам с тяжелыми нарушениями функции печени.

Способ применения и дозы

Внутрь один раз в сутки независимо от приема пищи.
Капсулы препарата Гардиум следует глотать целиком, не разжевывать, не открывать, поскольку содержимое капсулы может вызывать раздражение слизистой ротоглотки.
Доброкачественная гиперплазия предстательной железы Взрослые мужчины (включая пожилых)
Рекомендуемая доза препарата Гардиум - одна капсула (0,5 мг) один раз в сутки перорально. Капсулы следует принимать целиком.
Хотя улучшение на фоне применения препарата наступает довольно быстро, лечение следует продолжать не менее 6 месяцев для того, чтобы объективно оценить терапевтический эффект.
Для лечения ДГПЖ препарат Гардиум может быть назначен в качестве монотерапии или в комбинации с a1-адреноблокаторами.
Особые группы пациентов Пациенты с нарушениями функции почек.
При приеме 0,5 мг препарата в сутки почками выделяется менее 0,1% дозы, поэтому нет необходимости снижать дозу у пациентов с нарушениями функции почек.
Пациенты с нарушениями функции печени.
В настоящее время нет данных по применению препарата Гардиум у пациентов с нарушениями функции печени. Так как дутастерид подвергается интенсивному метаболизму, а его период полувыведения составляет 3-5 недель, необходимо соблюдать осторожность при лечении препаратом Гардиум пациентов с нарушениями функции печени.
Полная инструкция
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Дутастерид-Тева капс.
Дутастерид-Тева капс., 0.5 мг, 90 шт.
5.0
(4)
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1 вопрос
Инструкция

2 559 ₽

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5.0
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Рекомендуем

  • Финастерид-Тева таб. п/о плен., 5 мг, 30 шт.
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    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:447972126_0/content/content/toggleWishlist":{"skuId":"101543007743","productId":447972126,"offerId":"cASWqgNmUZLX4aTouVeCMA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ25nRweH7vvZnEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCJ6GztUBEP+rvaP6AhjW/Y0HIO7cwQc=","sign":"gZhdET70rWJSA85LXkewcgKHX3+LYBXDBLnxc0ZtUZE="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:447972126_0/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Финастерид-Тева таб. п/о плен., 5 мг, 30 шт.

    Цена 399 ₽
  • Финастерид-OBL таб. п/о плен., 5 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1785023072_1/content/content/toggleWishlist":{"skuId":"101872376881","productId":1785023072,"offerId":"C2Xod9H2HmYlxg16O6kx2Q","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ25nRweH7vvZnEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCOCUldMGELG4xMD7Ahixi7oIIO7cwQc=","sign":"i41yRDNwcU4rQeqbuJz5tjnNlpFV0THnsYhvERY0ws8="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1785023072_1/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Финастерид-OBL таб. п/о плен., 5 мг, 30 шт.

    Цена 301 ₽
  • Дуодарт капс. модиф. высвоб., 0.5 мг+0.4 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1430912450_2/content/content/toggleWishlist":{"skuId":"186920076","productId":1430912450,"offerId":"Gt_gzL2G77nNcs_iV-YqPQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ25nRweH7vvZnEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCML7p6oFEIzZkFkYx8aeCCDu3MEH","sign":"k8ZCPlEPxHZSpqdhnDc4SFBrvZiaohFxVf24Xdn+KyM="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1430912450_2/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Дуодарт капс. модиф. высвоб., 0.5 мг+0.4 мг, 30 шт.

    Цена 2 839 ₽
  • Пенестер таб. п/о плен., 5 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1430912452_3/content/content/toggleWishlist":{"skuId":"228054945","productId":1430912452,"offerId":"X-PVrPyOAuMa1Kt_xB8XOA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ25nRweH7vvZnEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCMT7p6oFEKGv32wYycv1ByDu3MEH","sign":"Q8u0J3JT6Pu/RQ2pzljskCOCEQlDWpb7Z0oW+/DFJ/c="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1430912452_3/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Пенестер таб. п/о плен., 5 мг, 30 шт.

    Цена 530 ₽
  • Таблетница из 14 секций на семь дней Утро-вечер
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217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5236584/img_id2572450964390581991.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5236584/img_id2572450964390581991.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5236584/img_id2572450964390581991.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5236584/img_id2572450964390581991.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5236584/img_id2572450964390581991.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5236584/img_id2572450964390581991.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/1937077/img_id4002630721296615326.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/1937077/img_id4002630721296615326.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/1937077/img_id4002630721296615326.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/1937077/img_id4002630721296615326.jpeg/240x320 240w, 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    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1883422910_4/content/content/toggleWishlist":{"skuId":"102066600726","productId":1883422910,"offerId":"MF1mPo1TjMmUyA9JACu0Ng","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ25nRweH7vvZnEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCL6Bi4IHEJb2kp38AhicnfkEIM3OPQ==","sign":"jSDVUA8eTjIElJyXWBZk2Sx5u3Ksh5pOj4fENpSwFs4="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1883422910_4/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Таблетница из 14 секций на семь дней Утро-вечер

    Цена 167 ₽ вместо 200
  • Цистофит-форте таб., 40 шт.
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    Цистофит-форте таб., 40 шт.

    Цена 493 ₽ вместо 690
  • Таблетница органайзер на неделю, контейнер для таблеток, бокс, на 7 дней, 4 приема, 28 ячеек
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    Таблетница органайзер на неделю, контейнер для таблеток, бокс, на 7 дней, 4 приема, 28 ячеек

    Цена 361 ₽ вместо 690
  • Тамсулозин Канон капс. кш/раств. с пролонг. высвоб., 0.4 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:228089089_7/content/content/toggleWishlist":{"skuId":"101601809961","productId":228089089,"offerId":"g2y0rc1eo1C3R4JrS4XMZA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ25nRweH7vvZnEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCIG64WwQqazCv/oCGM7C2Qcg7tzBBw==","sign":"BylOfbW9so7ZPHKLyb2SbU5/clPVckqDm7hWKvjgA/A="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:228089089_7/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Тамсулозин Канон капс. кш/раств. с пролонг. высвоб., 0.4 мг, 30 шт.

    Цена 403 ₽
  • Реклама
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  • Финаст таб. п/о плен., 5 мг, 30 шт.
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    Финаст таб. п/о плен., 5 мг, 30 шт.

    Цена 374 ₽
  • Тамсулозин-Вертекс таб. пролонг. высвоб. п/о плен., 0.4 мг, 30 шт.
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    Тамсулозин-Вертекс таб. пролонг. высвоб. п/о плен., 0.4 мг, 30 шт.

    Цена 445 ₽
  • Ципротерон-Тева таб., 50 мг, 50 шт.
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    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778175906_11/content/content/toggleWishlist":{"skuId":"663856005","productId":1778175906,"offerId":"VgIocXyEgJ0a7d-jRdjg-Q","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ25nRweH7vvZnEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCKKf888GEIXHxrwCGNb9jQcg7tzBBw==","sign":"mBtXvy3ubUPHaYiK/qc/e94n4TSqSCby3Eo++tmJgq4="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778175906_11/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Ципротерон-Тева таб., 50 мг, 50 шт.

    Цена 1 696 ₽
  • Тадалафил-СЗ таб. п/о плен., 20 мг, 4 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1430912592_12/content/content/gallery":{"title":"Тадалафил-СЗ таб. п/о плен., 20 мг, 4 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/5177817/img_id7847709708678270488.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5177817/img_id7847709708678270488.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5177817/img_id7847709708678270488.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5177817/img_id7847709708678270488.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5177817/img_id7847709708678270488.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5177817/img_id7847709708678270488.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/3699895/img_id4992889456566981621.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/3699895/img_id4992889456566981621.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/3699895/img_id4992889456566981621.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/3699895/img_id4992889456566981621.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/3699895/img_id4992889456566981621.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/3699895/img_id4992889456566981621.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ25nRweH7vvZnEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCND8p6oFEIrG9rsCGK7e0Acg7tzBBw==","sign":"rxbWl0Mj/64uqsPbFC7eaoBL03TjRm+ZRFvIITsDqcU="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1430912592_12/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Тадалафил-СЗ таб. п/о плен., 20 мг, 4 шт.

    Цена 260 ₽
  • Урорек капс., 8 мг, 30 шт.
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    Урорек капс., 8 мг, 30 шт.

    Цена 1 112 ₽
  • Таблетница на 7 дней Органайзер для лекарств
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    Таблетница на 7 дней Органайзер для лекарств

    Цена 273 ₽ вместо 279
  • Пилюля Таблетница на неделю Трансформер двойной ( 7 дней по 2 отделения)
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    Пилюля Таблетница на неделю Трансформер двойной ( 7 дней по 2 отделения)

    Цена 439 ₽ вместо 614
  • Таблетница органайзер на неделю утро / день / вечер; Органайзер для таблеток на 7 дней; Карманная аптечка
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    Цена 773 ₽ вместо 1 890
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    Таблетница пилюля на один день Мини, синяя (контейнер для таблеток)

    Цена 183 ₽ вместо 265
  • Таблетница - брелок на день, 1 раздел, контейнер для таблеток металлический маленький (черный матовый)
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    Таблетница - брелок на день, 1 раздел, контейнер для таблеток металлический маленький (черный матовый)

    Цена 223 ₽ вместо 599
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    Таблетница на 7 дней / органайзер / бокс / контейнер на неделю для хранения таблеток и лекарств 4 приема Clear Daswerk

    Цена 418 ₽ вместо 637
  • Пилюля Таблетница, с делителем ( 2 отделения )
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    Пилюля Таблетница, с делителем ( 2 отделения )

    Цена 201 ₽ вместо 291
  • Реклама
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  • Таблетница пенал - органайзер ABORNS на неделю 7 ячеек 7 дней
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    Таблетница пенал - органайзер ABORNS на неделю 7 ячеек 7 дней

    Цена 206 ₽ вместо 350
  • Таблетница Органайзер на 7 дней с делениями x1
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:926397045_23/content/content/toggleWishlist":{"skuId":"101285536574","productId":926397045,"offerId":"g4MDGesqNUBHR7PJoW2SXg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ25nRweH7vvZnEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCPXk3rkDEL7G2qj5AhiS9vcHIM3OPQ==","sign":"xvIpmBB6POEI4usuTcy2qWEZLDlmQMRRpsiRK1QgvC8="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:926397045_23/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Таблетница Органайзер на 7 дней с делениями x1

    Цена 180 ₽ вместо 184
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