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Описание

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Экталуст таб. п/о плен., 10 мг, 28 шт.

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Коротко о товаре

Артикул Маркета
3415707463
Тип препарата
Назначение
Действующее вещество
Возраст
от 15 лет
Инструкция
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Для лечения бронхиальной астмы препарат следует принимать вечером. При лечении аллергических ринитов препарат может приниматься в любое время суток по желанию пациента.\u003Cbr\u003E\u003Cbr\u003EВзрослые и дети с 15 лет: по 1 таблетке (10 мг) в сутки.\u003Cbr\u003E\u003Cbr\u003EОбщие рекомендации\u003Cbr\u003E\u003Cbr\u003EТерапевтическое действие препарата Экталуст на симптомы, отражающие течение бронхиальной астмы проявляется в течение первого дня. Пациенту следует продолжать прием препарата Экталуст как в период контролируемого течения бронхиальной астмы, так и в период обострения заболевания.\u003Cbr\u003E\u003Cbr\u003EДля пациентов пожилого возраста, пациентов с почечной недостаточностью, пациентов с легкими или среднетяжелыми нарушениями функции печени, коррекция дозы не требуется. Доза препарата одинакова для пациентов женского и мужского пола.\u003Cbr\u003E\u003Cbr\u003EНазначение препарата Экталуст одновременно с другими видами лечения астмы Экталуст можно добавлять к лечению пациента бронходилататорами и ингаляционными глюкокортикостероидами."},{"name":"Побочные действия","value":"В целом препарат Экталуст хорошо переносится. Побочные эффекты обычно бывают легкими и, как правило, не требуют отмены лечения. Общая частота побочных эффектов, о которых сообщалось при применении монтелукаста, сопоставима с таковой для плацебо.\u003Cbr\u003E\u003Cbr\u003EНарушения со стороны крови и лимфатической системы: повышение склонности к кровотечениям.\u003Cbr\u003E\u003Cbr\u003EНарушения со стороны иммунной системы: реакции гиперчувствительности, в том числе анафилаксия, эозинофильная инфильтрация печени (очень редко - \u003C0,01 %).\u003Cbr\u003E\u003Cbr\u003EНарушения психики: ажитация, в том числе агрессивное поведение или враждебность, тревожность, депрессия, дезориентация, патологические сновидения, галлюцинации, бессонница, раздражительность, беспокойство, сомнамбулизм, суицидальные мысли и поведение (суицидальность), тремор.\u003Cbr\u003E\u003Cbr\u003EНарушения со стороны нервной системы: головная боль, головокружение, сонливость, парестезия/гипестезия, гиперкинезия, судороги (очень редко - \u003C0,01 %).\u003Cbr\u003E\u003Cbr\u003EНарушения со стороны сердца: учащенное сердцебиение.\u003Cbr\u003E\u003Cbr\u003EНарушения со стороны дыхательной системы, органов грудной клетки и средостения: носовые кровотечения, инфекции верхних дыхательных путей, фарингит, кашель, синусит, ринорея.\u003Cbr\u003E\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта: диарея, диспепсия, тошнота, рвота, панкреатит, боль в животе, сухость во рту.\u003Cbr\u003E\u003Cbr\u003EНарушения со стороны печени и желчевыводяищх путей:\u003Cbr\u003E\u003Cbr\u003Eувеличение активности \"печеночных\" трансаминаз в сыворотке крови (аланинамино-трансфераза (АЛТ), аспартатаминотрансфераза (ACT)), гепатит (включая холестатические, гепатоцеллюлярные и смешанные поражения печени) (очень редко - \u003C0,01 %).\u003Cbr\u003E\u003Cbr\u003EНарушения со стороны колеи и подкожных тканей: ангионевротический отек, появление экхимозов, узловатая эритема, многоформная эритема, зуд, сыпь, крапивница.\u003Cbr\u003E\u003Cbr\u003EНарушения со стороны скелетно-мышечной и соединительной ткани: артралгия, миалгия, включая спазмы мышц.\u003Cbr\u003E\u003Cbr\u003EОбщие расстройства и нарушения в месте введения: астения (слабость)/усталость, отеки, пирексия, жажда. В редких случаях у пациентов с бронхиальной астмой отмечается развитие синдрома Чарджа-Стросса."},{"name":"Фармакологическое действие","value":"Монтелукаст обладает способностью ингибировать бронхоспазм, обусловленный вдыханием LTD4 в весьма низких дозах. Бронходилатация наблюдается в течение 2-х часов после приема препарата внутрь. Эффект бронходилатации, вызванный бета-адреномиметиками, дополняется действием монтелукаста. Монтелукаст ингибирует раннюю и позднюю фазы бронхоспазма, вызванного введением антигена. Монтелукаст снижает количество эозинофилов в периферической крови, в дыхательных путях (в мокроте) взрослых пациентов и детей и улучшает контроль за течением бронхиальной астмы. Монтелукаст существенно улучшает утренний объем форсированного выдоха (ОФВ) за 1 секунду, максимальную объемную скорость выдоха (МОСВ) и существенно снижает потребность в бета-адреномиметиках.\u003Cbr\u003E\u003Cbr\u003EМонтелукаст усиливает действие ингаляционных глюкокортикостероидов. Монтелукаст существенно ослабляет бронхоспазм, возникающий на фоне физической нагрузки. У пациентов с бронхиальной астмой, чувствительных к ацетилсалициловой кислоте, и принимающих сопутствующие ингаляционные пероральные глюкокортикостероиды, лечение монтелукастом приводит к существенному улучшению контроля за симптомами бронхиальной астмы.\u003Cbr\u003E\u003Cbr\u003EКроме того, есть данные о некотором противовоспалительном действии монтелукаста."},{"name":"Фармакологическая группа","value":"противовоспалительное антибронхоконстрикторное средство - лейкотриеновых рецепторов блокатор"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-astmy","categoryId":"15756897","navnodeId":"72498","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 15 лет"},{"name":"Условия хранения","value":"В сухом, защищенном от света месте при температуре не выше 25 °С.\u003Cbr\u003E\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы: Данных о симптомах передозировки при приеме препарата пациентами с бронхиальной астмой в дозе, превышающей 200 мг в сутки в течение 22 недель и в дозе 900 мг в сутки в течение 1 недели, не выявлено. Имеются сообщения об острой передозировке монтелукаста у детей (прием не менее 150 мг препарата в сутки). Наиболее частыми нежелательными явлениями были чувство жажды, сонливость, мидриаз, гиперкинезы и боли в животе.\u003Cbr\u003E\u003Cbr\u003EЛечение: Лечение симптоматическое. Отсутствует информация о специфическом лечении передозировки препаратом Экталуст. Данных о возможности выведения монтелукаста путем перитонеального диализа или гемодиализа нет."},{"name":"Применение при беременности и кормлении грудью","value":"Экталуст следует назначать при беременности и в период грудного вскармливания только в том случае, если ожидаемая польза для матери превышает потенциальный риск для плода или ребенка."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Данных, свидетельствующих о том, что прием препарата Экталуст влияет на способность управлять автотранспортом или движущимися механизмами, не выявлено. Однако при применении препарата имеются такие побочные эффекты, как головокружение и сонливость. Ввиду этого, следует соблюдать осторожность при управлении автотранспортом и работе, требующей быстроты психомоторных реакций."},{"name":"Особые указания","value":"Эффективность препарата Экталуст для перорального приема в отношении лечения острых приступов бронхиальной астмы не установлена, поэтому препарат Экталуст в таблетках не рекомендовано назначать для лечения острых приступов бронхиальной астмы. Препарат Экталуст не должен заменять ингаляционные или пероральные глюкокортикостероиды.\u003Cbr\u003E\u003Cbr\u003EОтсутствуют данные, свидетельствующие о возможности снижения дозы пероральных глюкокортикостероидов при сопутствующем применении препарата Экталуст.\u003Cbr\u003E\u003Cbr\u003EВ редких случаях у пациентов, принимающих препараты для лечения бронхиальной астмы, включая препарат Экталуст, может возникнуть системная эозинофилия, иногда сопровождающаяся клиническими проявлениями васкулита и синдрома Чарджа-Стросса. Такое состояние обычно лечат системными глюкокортикостероидами. Такие случаи обычно, но не всегда, связаны с уменьшением дозы или отменой пероральных глюкокортикостероидов. Нельзя ни исключить, ни подтвердить вероятность того, что прием антагонистов лейкотриеновых рецепторов может быть связан с возникновением синдрома Чарджа-Стросса. Врачи должны знать о возможности возникновения у пациентов эозино-филии, васкулитной сыпи, нарастания легочных симптомов, осложнений со стороны сердца и/или нейропатии. Пациентам, у которых возникли вышеперечисленные симптомы, следует пройти повторное обследование, а режим их лечения должен быть пересмотрен.\u003Cbr\u003E\u003Cbr\u003EПрепарат не применяется для купирования приступов бронхиальной астмы в качестве препарата экстренной помощи, однако его прием не следует прекращать в период обострения.\u003Cbr\u003E\u003Cbr\u003EПациенты с подтвержденной аллергией к ацетилсалициловой кислоте и другим нестероидным противовоспалительным препаратам (НПВП) не должны принимать эти препараты в период лечения препаратом Экталуст, поскольку он, улучшая дыхательную функцию у пациентов с аллергической бронхиальной астмой, тем не менее, не может полностью предотвратить бронхоконстрикцию, вызванную НПВП."},{"name":"Взаимодействие","value":"Экталуст можно назначать вместе с другими лекарственными средствами, традиционно применяемыми для профилактики и длительного лечения бронхиальной астмы. Рекомендуемая клиническая доза монтелукаста не оказывала клинически значимого эффекта на фармакокинетику следующих препаратов: теофиллина, преднизона, преднизолона, пероральных противозачаточных средств (этинилэстрадиол/норэтиндрон 35/1), терфенадина, дигоксина и варфарина.\u003Cbr\u003E\u003Cbr\u003EAUC уменьшается у лиц, одновременно получающих фенобарбитал (примерно на 40 %), однако коррекция режима дозирования препарата Экталуст таким пациентам не требуется. Поскольку монтелукаст метаболизируется изоферментом CYP3A4 следует соблюдать осторожность, особенно у детей, если монтелукаст одновременно назначается с препаратами, индуцирующими изофермент CYP3A4, такими как фенитоин, фенобарбитал и рифампицин.\u003Cbr\u003E\u003Cbr\u003EВ исследованиях in vitro показано, что монтелукаст является потенциальным ингибитором изофермента CYP2C8, однако данные клинических исследований взаимодействия препарат - препарат, включающих моителукаст и росиглитазон (предварительный субстрат представителя медицинских препаратов, первично метаболизирующихся изоферментом CYP2C8) показали, что дозы монтелукаста не ингибируют изофермент CYP2C8 in vivo. Следовательно, монтелукаст не оказывает заметного влияния на метаболизм препаратов, метаболизирующихся этим ферментом (например, паклитаксел, росиглитазон и репаглинид).\u003Cbr\u003E\u003Cbr\u003EПри приеме высоких доз монтелукаста (при 20- и 60-кратном превышении рекомендованной дозы для взрослых) наблюдается снижение концентрации теофиллина в плазме. Этот эффект не отмечается при приеме препарата в рекомендованных дозах по 10 мг в сутки. Бронходилататоры: Экталуст можно добавлять к лечению пациентов, у которых астма не контролируется применением одних бронходилататоров. При достижении терапевтического эффекта (обычно после первой дозы) на фоне терапии препаратом Экталуст дозу бронходилататоров можно постепенно снижать.\u003Cbr\u003E\u003Cbr\u003EИнгаляционные глюкокортикостероиды: Лечение препаратом Экталуст обеспечивает дополнительный терапевтический эффект пациентам, получающим лечение ингаляционными глюкокортикостероидами. При достижении стабилизации состояния пациента возможно снижение дозы глюкокортикостероидов. Дозу глюкокортикостероидов нужно снижать постепенно, под наблюдением врача. У некоторых пациентов прием ингаляционных глюкокортикостероидов может быть полностью отменен. Не рекомендуется резкая замена терапии ингаляционными глюкокортикостероидами назначением препарата Экталуст ."},{"name":"Регистрационный номер","value":"ЛП-002249"},{"name":"Дата государственной регистрации","value":"26.09.2018"},{"name":"Владелец регистрационного удостоверения","value":"Канонфарма продакшн","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-astmy","categoryId":"15756897","navnodeId":"72498","glfilters":["34324371:35649313","7893318:16146766"]}}},{"name":"Изготовитель","value":"Канонфарма продакшн"},{"name":"Фасовщик","value":"Канонфарма продакшн"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Экталуст","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-astmy","categoryId":"15756897","navnodeId":"72498","glfilters":["17796364:18053326"]}}},{"name":"Срок годности","value":"1 г."}]}},"fullSpecsGrouped":{"10413752594622627620":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"дыхательная система, легкие, носовая полость"},{"name":"Назначение","value":"аллергический ринит, бронхиальная астма, профилактика и лечение бронхоспазма"},{"name":"Показания к применению","value":"— длительное лечение и профилактика бронхиальной астмы, включая предупреждение дневных и ночных симптомов заболевания;\u003Cbr\u003E— лечение \"аспириновой\" астмы;\u003Cbr\u003E— профилактика бронхоспазма, вызванного физической нагрузкой;\u003Cbr\u003E— купирование дневных и ночных симптомов постоянных и сезонных аллергических ринитов."},{"name":"Противопоказания","value":"— гиперчувствительность к любому из компонентов препарата;\u003Cbr\u003E— детский возраст до 15 лет."},{"name":"Состав","value":"Активное вещество: монтелукаст натрия 10,4 мг, в пересчете на монтелукаст 10 мг; вспомогательные вещества: кальция гидрофосфат 50 мг, кроскармеллоза натрия 7 мг, маннитол 78 мг, масло касторовое гидрогенизированное 2 мг, магния стеарат 2 мг, пови-дон 10 мг, целлюлоза микрокристаллическая 50,6 мг; состав пленочной оболочки: Опадрай белый 6 мг, в том числе: гипромеллоза (гидрокси-пропилметилцеллюлоза) 2,025 мг, гипролоза (гидроксипропилцеллюлоза) 2,025 мг, тальк 1,2 мг, титана диоксид 0,75 мг."},{"name":"Действующее вещество","value":"Монтелукаст"},{"name":"Способ применения и дозы","value":"Внутрь, один раз в сутки, независимо от приема пищи. Для лечения бронхиальной астмы препарат следует принимать вечером. При лечении аллергических ринитов препарат может приниматься в любое время суток по желанию пациента.\u003Cbr\u003E\u003Cbr\u003EВзрослые и дети с 15 лет: по 1 таблетке (10 мг) в сутки.\u003Cbr\u003E\u003Cbr\u003EОбщие рекомендации\u003Cbr\u003E\u003Cbr\u003EТерапевтическое действие препарата Экталуст на симптомы, отражающие течение бронхиальной астмы проявляется в течение первого дня. Пациенту следует продолжать прием препарата Экталуст как в период контролируемого течения бронхиальной астмы, так и в период обострения заболевания.\u003Cbr\u003E\u003Cbr\u003EДля пациентов пожилого возраста, пациентов с почечной недостаточностью, пациентов с легкими или среднетяжелыми нарушениями функции печени, коррекция дозы не требуется. Доза препарата одинакова для пациентов женского и мужского пола.\u003Cbr\u003E\u003Cbr\u003EНазначение препарата Экталуст одновременно с другими видами лечения астмы Экталуст можно добавлять к лечению пациента бронходилататорами и ингаляционными глюкокортикостероидами."},{"name":"Побочные действия","value":"В целом препарат Экталуст хорошо переносится. Побочные эффекты обычно бывают легкими и, как правило, не требуют отмены лечения. Общая частота побочных эффектов, о которых сообщалось при применении монтелукаста, сопоставима с таковой для плацебо.\u003Cbr\u003E\u003Cbr\u003EНарушения со стороны крови и лимфатической системы: повышение склонности к кровотечениям.\u003Cbr\u003E\u003Cbr\u003EНарушения со стороны иммунной системы: реакции гиперчувствительности, в том числе анафилаксия, эозинофильная инфильтрация печени (очень редко - \u003C0,01 %).\u003Cbr\u003E\u003Cbr\u003EНарушения психики: ажитация, в том числе агрессивное поведение или враждебность, тревожность, депрессия, дезориентация, патологические сновидения, галлюцинации, бессонница, раздражительность, беспокойство, сомнамбулизм, суицидальные мысли и поведение (суицидальность), тремор.\u003Cbr\u003E\u003Cbr\u003EНарушения со стороны нервной системы: головная боль, головокружение, сонливость, парестезия/гипестезия, гиперкинезия, судороги (очень редко - \u003C0,01 %).\u003Cbr\u003E\u003Cbr\u003EНарушения со стороны сердца: учащенное сердцебиение.\u003Cbr\u003E\u003Cbr\u003EНарушения со стороны дыхательной системы, органов грудной клетки и средостения: носовые кровотечения, инфекции верхних дыхательных путей, фарингит, кашель, синусит, ринорея.\u003Cbr\u003E\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта: диарея, диспепсия, тошнота, рвота, панкреатит, боль в животе, сухость во рту.\u003Cbr\u003E\u003Cbr\u003EНарушения со стороны печени и желчевыводяищх путей:\u003Cbr\u003E\u003Cbr\u003Eувеличение активности \"печеночных\" трансаминаз в сыворотке крови (аланинамино-трансфераза (АЛТ), аспартатаминотрансфераза (ACT)), гепатит (включая холестатические, гепатоцеллюлярные и смешанные поражения печени) (очень редко - \u003C0,01 %).\u003Cbr\u003E\u003Cbr\u003EНарушения со стороны колеи и подкожных тканей: ангионевротический отек, появление экхимозов, узловатая эритема, многоформная эритема, зуд, сыпь, крапивница.\u003Cbr\u003E\u003Cbr\u003EНарушения со стороны скелетно-мышечной и соединительной ткани: артралгия, миалгия, включая спазмы мышц.\u003Cbr\u003E\u003Cbr\u003EОбщие расстройства и нарушения в месте введения: астения (слабость)/усталость, отеки, пирексия, жажда. В редких случаях у пациентов с бронхиальной астмой отмечается развитие синдрома Чарджа-Стросса."},{"name":"Фармакологическое действие","value":"Монтелукаст обладает способностью ингибировать бронхоспазм, обусловленный вдыханием LTD4 в весьма низких дозах. Бронходилатация наблюдается в течение 2-х часов после приема препарата внутрь. Эффект бронходилатации, вызванный бета-адреномиметиками, дополняется действием монтелукаста. Монтелукаст ингибирует раннюю и позднюю фазы бронхоспазма, вызванного введением антигена. Монтелукаст снижает количество эозинофилов в периферической крови, в дыхательных путях (в мокроте) взрослых пациентов и детей и улучшает контроль за течением бронхиальной астмы. Монтелукаст существенно улучшает утренний объем форсированного выдоха (ОФВ) за 1 секунду, максимальную объемную скорость выдоха (МОСВ) и существенно снижает потребность в бета-адреномиметиках.\u003Cbr\u003E\u003Cbr\u003EМонтелукаст усиливает действие ингаляционных глюкокортикостероидов. Монтелукаст существенно ослабляет бронхоспазм, возникающий на фоне физической нагрузки. У пациентов с бронхиальной астмой, чувствительных к ацетилсалициловой кислоте, и принимающих сопутствующие ингаляционные пероральные глюкокортикостероиды, лечение монтелукастом приводит к существенному улучшению контроля за симптомами бронхиальной астмы.\u003Cbr\u003E\u003Cbr\u003EКроме того, есть данные о некотором противовоспалительном действии монтелукаста."},{"name":"Фармакологическая группа","value":"противовоспалительное антибронхоконстрикторное средство - лейкотриеновых рецепторов блокатор"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 15 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"В сухом, защищенном от света месте при температуре не выше 25 °С.\u003Cbr\u003E\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы: Данных о симптомах передозировки при приеме препарата пациентами с бронхиальной астмой в дозе, превышающей 200 мг в сутки в течение 22 недель и в дозе 900 мг в сутки в течение 1 недели, не выявлено. Имеются сообщения об острой передозировке монтелукаста у детей (прием не менее 150 мг препарата в сутки). Наиболее частыми нежелательными явлениями были чувство жажды, сонливость, мидриаз, гиперкинезы и боли в животе.\u003Cbr\u003E\u003Cbr\u003EЛечение: Лечение симптоматическое. Отсутствует информация о специфическом лечении передозировки препаратом Экталуст. Данных о возможности выведения монтелукаста путем перитонеального диализа или гемодиализа нет."},{"name":"Применение при беременности и кормлении грудью","value":"Экталуст следует назначать при беременности и в период грудного вскармливания только в том случае, если ожидаемая польза для матери превышает потенциальный риск для плода или ребенка."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Данных, свидетельствующих о том, что прием препарата Экталуст влияет на способность управлять автотранспортом или движущимися механизмами, не выявлено. Однако при применении препарата имеются такие побочные эффекты, как головокружение и сонливость. Ввиду этого, следует соблюдать осторожность при управлении автотранспортом и работе, требующей быстроты психомоторных реакций."},{"name":"Особые указания","value":"Эффективность препарата Экталуст для перорального приема в отношении лечения острых приступов бронхиальной астмы не установлена, поэтому препарат Экталуст в таблетках не рекомендовано назначать для лечения острых приступов бронхиальной астмы. Препарат Экталуст не должен заменять ингаляционные или пероральные глюкокортикостероиды.\u003Cbr\u003E\u003Cbr\u003EОтсутствуют данные, свидетельствующие о возможности снижения дозы пероральных глюкокортикостероидов при сопутствующем применении препарата Экталуст.\u003Cbr\u003E\u003Cbr\u003EВ редких случаях у пациентов, принимающих препараты для лечения бронхиальной астмы, включая препарат Экталуст, может возникнуть системная эозинофилия, иногда сопровождающаяся клиническими проявлениями васкулита и синдрома Чарджа-Стросса. Такое состояние обычно лечат системными глюкокортикостероидами. Такие случаи обычно, но не всегда, связаны с уменьшением дозы или отменой пероральных глюкокортикостероидов. Нельзя ни исключить, ни подтвердить вероятность того, что прием антагонистов лейкотриеновых рецепторов может быть связан с возникновением синдрома Чарджа-Стросса. Врачи должны знать о возможности возникновения у пациентов эозино-филии, васкулитной сыпи, нарастания легочных симптомов, осложнений со стороны сердца и/или нейропатии. Пациентам, у которых возникли вышеперечисленные симптомы, следует пройти повторное обследование, а режим их лечения должен быть пересмотрен.\u003Cbr\u003E\u003Cbr\u003EПрепарат не применяется для купирования приступов бронхиальной астмы в качестве препарата экстренной помощи, однако его прием не следует прекращать в период обострения.\u003Cbr\u003E\u003Cbr\u003EПациенты с подтвержденной аллергией к ацетилсалициловой кислоте и другим нестероидным противовоспалительным препаратам (НПВП) не должны принимать эти препараты в период лечения препаратом Экталуст, поскольку он, улучшая дыхательную функцию у пациентов с аллергической бронхиальной астмой, тем не менее, не может полностью предотвратить бронхоконстрикцию, вызванную НПВП."},{"name":"Взаимодействие","value":"Экталуст можно назначать вместе с другими лекарственными средствами, традиционно применяемыми для профилактики и длительного лечения бронхиальной астмы. Рекомендуемая клиническая доза монтелукаста не оказывала клинически значимого эффекта на фармакокинетику следующих препаратов: теофиллина, преднизона, преднизолона, пероральных противозачаточных средств (этинилэстрадиол/норэтиндрон 35/1), терфенадина, дигоксина и варфарина.\u003Cbr\u003E\u003Cbr\u003EAUC уменьшается у лиц, одновременно получающих фенобарбитал (примерно на 40 %), однако коррекция режима дозирования препарата Экталуст таким пациентам не требуется. Поскольку монтелукаст метаболизируется изоферментом CYP3A4 следует соблюдать осторожность, особенно у детей, если монтелукаст одновременно назначается с препаратами, индуцирующими изофермент CYP3A4, такими как фенитоин, фенобарбитал и рифампицин.\u003Cbr\u003E\u003Cbr\u003EВ исследованиях in vitro показано, что монтелукаст является потенциальным ингибитором изофермента CYP2C8, однако данные клинических исследований взаимодействия препарат - препарат, включающих моителукаст и росиглитазон (предварительный субстрат представителя медицинских препаратов, первично метаболизирующихся изоферментом CYP2C8) показали, что дозы монтелукаста не ингибируют изофермент CYP2C8 in vivo. Следовательно, монтелукаст не оказывает заметного влияния на метаболизм препаратов, метаболизирующихся этим ферментом (например, паклитаксел, росиглитазон и репаглинид).\u003Cbr\u003E\u003Cbr\u003EПри приеме высоких доз монтелукаста (при 20- и 60-кратном превышении рекомендованной дозы для взрослых) наблюдается снижение концентрации теофиллина в плазме. Этот эффект не отмечается при приеме препарата в рекомендованных дозах по 10 мг в сутки. Бронходилататоры: Экталуст можно добавлять к лечению пациентов, у которых астма не контролируется применением одних бронходилататоров. При достижении терапевтического эффекта (обычно после первой дозы) на фоне терапии препаратом Экталуст дозу бронходилататоров можно постепенно снижать.\u003Cbr\u003E\u003Cbr\u003EИнгаляционные глюкокортикостероиды: Лечение препаратом Экталуст обеспечивает дополнительный терапевтический эффект пациентам, получающим лечение ингаляционными глюкокортикостероидами. При достижении стабилизации состояния пациента возможно снижение дозы глюкокортикостероидов. Дозу глюкокортикостероидов нужно снижать постепенно, под наблюдением врача. У некоторых пациентов прием ингаляционных глюкокортикостероидов может быть полностью отменен. Не рекомендуется резкая замена терапии ингаляционными глюкокортикостероидами назначением препарата Экталуст ."},{"name":"Регистрационный номер","value":"ЛП-002249"},{"name":"Дата государственной регистрации","value":"26.09.2018"},{"name":"Владелец регистрационного удостоверения","value":"Канонфарма продакшн"},{"name":"Изготовитель","value":"Канонфарма продакшн"},{"name":"Фасовщик","value":"Канонфарма продакшн"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Экталуст"},{"name":"Срок годности","value":"1 г."}]}],"transitionId":"tr_17129698464721936461"}}}}
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Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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Цена с картой Яндекс Пэй:557 ₽

Скидка: 22%
–22 %
Вместо: 563 ₽713 ₽
  • 24-26 июня, самовывоз • 0 ₽
POLZAru
Рейтинг 4.9 из 5
39Котзывов
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Инструкция

Показания к применению

— длительное лечение и профилактика бронхиальной астмы, включая предупреждение дневных и ночных симптомов заболевания;
— лечение "аспириновой" астмы;
— профилактика бронхоспазма, вызванного физической нагрузкой;
— купирование дневных и ночных симптомов постоянных и сезонных аллергических ринитов.

Противопоказания

— гиперчувствительность к любому из компонентов препарата;
— детский возраст до 15 лет.

Способ применения и дозы

Внутрь, один раз в сутки, независимо от приема пищи. Для лечения бронхиальной астмы препарат следует принимать вечером. При лечении аллергических ринитов препарат может приниматься в любое время суток по желанию пациента.

Взрослые и дети с 15 лет: по 1 таблетке (10 мг) в сутки.

Общие рекомендации

Терапевтическое действие препарата Экталуст на симптомы, отражающие течение бронхиальной астмы проявляется в течение первого дня. Пациенту следует продолжать прием препарата Экталуст как в период контролируемого течения бронхиальной астмы, так и в период обострения заболевания.

Для пациентов пожилого возраста, пациентов с почечной недостаточностью, пациентов с легкими или среднетяжелыми нарушениями функции печени, коррекция дозы не требуется. Доза препарата одинакова для пациентов женского и мужского пола.

Назначение препарата Экталуст одновременно с другими видами лечения астмы Экталуст можно добавлять к лечению пациента бронходилататорами и ингаляционными глюкокортикостероидами.
Полная инструкция
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Экталуст таб. п/о плен.
Экталуст таб. п/о плен., 10 мг, 28 шт.
5.0
(5)
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Инструкция

Цена с картой Яндекс Пэй:557 ₽

Скидка: 22%
–22 %
Вместо: 563 ₽713 ₽
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5.0
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У продавца:5 оценок·2 отзыва
У всех продавцов:13 оценок·6 отзывов
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user avatar
Год назад • Марина Дарчинян • Куплен на Маркете
Комментарий: Препарат предназначен астматикам, принимается 1 раз в сутки. Одна упаковка на месяц, есть аналоги, но этот, по моей оценке, лучше. Рекомендован пульманологом для комплесной терапии.
user avatar
2 месяца назад • Татьяна . • Куплен на Маркете
Достоинства: хороший препарат
Недостатки: нет
Посмотреть все отзывы на Маркете
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    Таблетница 1секц d4*6,5см с таблеторезкой бел от 655398

    Цена 177 ₽ вместо 600
  • Таблетница из 14 секций на семь дней Утро-вечер
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    Таблетница из 14 секций на семь дней Утро-вечер

    Цена 177 ₽ вместо 220
  • Таблетница - брелок на день, 1 раздел, контейнер для таблеток металлический маленький (черный)
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    Таблетница - брелок на день, 1 раздел, контейнер для таблеток металлический маленький (черный)

    Цена 211 ₽ вместо 599
  • Таблетница на день мини для капсул контейнер для таблеток белый
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    Таблетница на день мини для капсул контейнер для таблеток белый

    Цена 282 ₽ вместо 750
  • Таблетница пенал - органайзер ABORNS на неделю 7 ячеек 7 дней
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    Таблетница пенал - органайзер ABORNS на неделю 7 ячеек 7 дней

    Цена 168 ₽ вместо 400
  • Таблетница компактная /органайзер аптечка/ контейнер для таблеток БАД Panda_Home (синего цвета)
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    Таблетница компактная /органайзер аптечка/ контейнер для таблеток БАД Panda_Home (синего цвета)

    Цена 186 ₽ вместо 380
  • Таблетница на день / контейнер для лекарств
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    Таблетница на день / контейнер для лекарств

    Цена 480 ₽ вместо 999
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    Реклама
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  • Контейнер для хранения/таблетница/кейс для таблеток
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    Контейнер для хранения/таблетница/кейс для таблеток

    Цена 367 ₽ вместо 699
  • Таблетница органайзер на неделю утро / день / вечер; Органайзер для таблеток на 7 дней; Карманная аптечка
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    Таблетница органайзер на неделю утро / день / вечер; Органайзер для таблеток на 7 дней; Карманная аптечка

    Цена 735 ₽ вместо 1 890
  • Таблетница на 7 дней / органайзер / бокс / контейнер на неделю для хранения таблеток и лекарств 4 приема Clear Daswerk
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    Таблетница на 7 дней / органайзер / бокс / контейнер на неделю для хранения таблеток и лекарств 4 приема Clear Daswerk

    Цена 460 ₽ вместо 637
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